Krishna P.L. Bhat, Ph.D.
Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2001 | University of Illinois, Chicago, IL, USA, PHD, Research |
Postgraduate Training
| 2004-2006 | Research Fellowship, Neuropathology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2001-2004 | Research Fellowship, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Assistant Professor, Department of Pathology - Research, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2015
Instructor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2012
Honors & Awards
| 2016 | Young Investigator Award, Global Academic Programs Workshop at Oslo |
| 2014 | Provost's Wall of Science, M. D. Anderson Cancer Center |
| 2011 | Caroline Ross Endowment Fellowship, MD Anderson Cancer Center |
| 2010 | Merck Adult Basic Research Award, Society of Neuro-Oncology |
| 2005 | Basic Research Fellowship, American Brain Tumor Association |
| 2005 | Odyssey Special Fellow Award, Theodore N. Law Award for Scientific Achievement |
| 1999 | Pharmacia and Upjohn-Young Investigator Award, American Association for Cancer Research |
| 1999 | John Nuveen International Student Award for exceptional academic standing, University of Illinois International Awards |
Selected Publications
Peer-Reviewed Articles
- Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Kim S, Mohyeldin A, Pavlyukov MS, Zhang Z, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. FOXD1-ALDH1A3 signaling is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells. Cancer Res 76(24):7219-7230. e-Pub 2016. PMID: 27569208.
- Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. Cancer Cell 29(2):201-213, 2016. PMID: 26859459.
- Gabrusiewicz K, Rodriguez B, Wei J, Hashimoto Y, Healy LM, Maiti SN, Thomas G, Zhou S, Wang Q, Elakkad A, Liebelt BD, Yaghi NK, Ezhilarasan R, Huang N, Weinberg JS, Prabhu SS, Rao G, Sawaya R, Langford LA, Bruner JM, Fuller GN, Bar-Or A, Li W, Colen RR, Curran MA, Bhat KP, Antel JP, Cooper LJ, Sulman EP, Heimberger AB. Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype. JCI Insight 1(2), 2016. e-Pub 2016. PMID: 26973881.
- Sathyan P, Zinn PO, Marisetty AL, Liu B, Kamal MM, Singh SK, Bady P, Lu L, Wani KM, Veo BL, Gumin J, Kassem DH, Robinson F, Weng C, Baladandayuthapani V, Suki D, Colman H, Bhat KP, Sulman EP, Aldape K, Colen RR, Verhaak RG, Lu Z, Fuller GN, Huang S, Lang FF, Sawaya R, Hegi M, Majumder S. Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact. J Neurosci 35(45):15097-15112, 2015. PMID: 26558781.
- Balasubramaniyan V, Vaillant B, Wang S, Gumin J, Butalid ME, Sai K, Mukheef F, Kim SH, Boddeke HW, Lang F, Aldape K, Sulman EP, Bhat KP, Colman H. Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting. Oncotarget 6(31):31007-31017, 2015. PMID: 26307681.
- Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Salcini AE, Nakano I. EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner. Stem Cell Reports 4(2):226-238, 2015. e-Pub 2015. PMID: 25601206.
- Conroy S, Kruyt FA, Joseph JV, Balasubramaniyan V, Bhat KP, Wagemakers M, Enting RH, Walenkamp AM, den Dunnen WF. Subclassification of Newly Diagnosed Glioblastomas through an Immunohistochemical Approach. PLoS One 9(12):e115687, 2014. e-Pub 2014. PMID: 25546404.
- Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. Mesenchymal differentiation induced by NFκB promotes radiation resistance in glioblastoma. Cancer Cell 24(3):331-346, 2013. e-Pub 2013. PMID: 23993863.
- Doucette TA, Kong LY, Yang Y, Ferguson SD, Yang J, Wei J, Qiao W, Fuller GN, Bhat KP, Aldape K, Priebe W, Bögler O, Heimberger AB, Rao G. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol 14(9):1136-2012. e-Pub 2012. PMID: 22753228.
- Bhat KP, Salazar KL, Balasubramaniyan V, Wani K, Heathcock L, Hollingsworth F, James JD, Gumin J, Diefes KL, Kim SH, Turski A, Azodi Y, Yang Y, Doucette T, Colman H, Sulman EP, Lang FF, Rao G, Copray S, Vaillant BD, Aldape KD. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev. 25(24):2594-2609, 2011. PMID: 22190458.
- Macias E, Jin A, Deisenroth C, Bhat KP, Mao H, Lindström MS, Zhang Y. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell 18(3):231-243, 2010. PMID: 20832751.
- Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K, Cancer Genome Atlas Research Network. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17(5):510-522, 2010. e-Pub 2010. PMID: 20399149.
- Colman H, Zhang L, Sulman EP, McDonald JM, Shooshtari NL, Rivera A, Popoff S, Nutt CL, Louis DN, Cairncross JG, Gilbert MR, Phillips HS, Mehta MP, Chakravarti A, Pelloski CE, Bhat KP, Feuerstein BG, Jenkins RB, Aldape K. A multigene predictor of outcome in glioblastoma. Neuro Oncol 12(1):49-57, 2010. e-Pub 2009. PMID: 20150367.
- Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS, Bhat KP, Godfrey VL, Evan GI, Zhang Y. Targeted Inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights inot p53 regulation. Cancer Cell 12(4):355-366, 2007. PMID: 17936560.
Editorials
- Zadeh G, Bhat KP, Aldape K. EGFR and EGFRVIII: partners in crime. Cancer Cell 24(4):403-404, 2013. PMID: 24135276.
- Bhat KP, and Aldape K. Not expecting the unexpected: Diacylglycerol Kinase Alpha as a cancer target. Cancer Discovery 3(7):726-727, 2013. PMID: 23847350.
Grant & Contract Support
| Title: | Radio-sensitization of glioma stem cells via NF-kB blockade |
| Funding Source: | Center for Radiation Oncology Research |
| Role: | Principal Investigator |
| Title: | A non-neural origin for the mesenchymal subtype of glioblastoma |
| Funding Source: | Sister Institution Network Fund |
| Role: | Co-Principal Investigator |