Lorraine R. Hill
Department of Veterinary Medicine and Surgery, Division of Basic Sciences
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Veterinary Medicine and Surgery, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
I am a highly skilled veterinary clinician with broad experience caring for a wide variety of species and animal models. My collaborative skills are highlighted by my publication history and my experience working with many types of people in a variety of circumstances (private practice, academia, health-care and shelter medicine). I possess the ability to manage large, complex animal programs and have extensive experience with genetically altered mice. I can provide whatever kind of support MD Anderson investigators need to accomplish their research goals. I have experience with drug development, and with GLP. I have comprehensive knowledge of the regulatory and compliance processes related to animal research and an in-depth understanding of the AAALAC accreditation process. I have provided comparative medicine expertise for cancer prevention and therapy studies using animal models. These projects have included development, in life monitoring, sample collection, and documentation of studies using genetically engineered, orthotopic tumor, and patient-derived xenograft models.
Education & Training
Degree-Granting Education
| 1991 | Texas A&M University, College Station, TX, USA, DVM, Veterinary Medicine |
Postgraduate Training
| 1997-1998 | Research Fellowship, Comparative Medicine, MD Anderson Cancer Center, Houston, TX |
Board Certifications
| 2002 | American College of Laboratory Animal Medicine |
Experience & Service
Academic Appointments
Advisory Committee/Site Director, Gulf Coast Consortium Postdoctoral Veterinary Training Program, Houston, TX, 2010 - 2012
Assistant Professor, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 2004 - 2012
Assistant Professor, Department of Veterinary Medicine and Surgery, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, 2000 - 2003
Associate Faculty, Graduate School of Biomedical Sciences, Houston, TX, 1999 - 2002
Instructor, Department of Comparative Medicine, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX, 1998 - 2000
Administrative Appointments/Responsibilities
Education Director (Department level), Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - Present
Section Chief, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - Present
Consultantships
Consultant, InGeneron, Inc, Houston, Texas, 2012 - 2012
Member, Council on Accreditation, AAALAC, International, Frederick, Maryland, 2010 - Present
Consultant, Harlan Laboratories, Inc, Houston, Texas, 2009 - 2012
Ad hoc consultant, Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC), Frederick, Maryland, 2003 - 2010
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Hill LR, Huang SY, Gagea M. Diaphragmatic hernia of the stomach with gastric rupture in a domestic pig. Comp Med 66(5):399-404, 2016. PMID: 27780007.
- Nehete PN, Nehete BP, Hill L, Manuri PR, Baladandayuthapani V, Feng L, Simmons J, Sastry KJ. Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail. Virology 370(1):130-41, 2008. e-Pub 2007. PMID: 17920095.
- Wood CE, Usborne AL, Starost MF, Tarara RP, Hill LR, Wilkinson LM, Geisinger KR, Feiste EA, Cline JM. Hyperplastic and neoplastic lesions of the mammary gland in macaques. Vet Pathol 43(4):471-83, 2006. PMID: 16846989.
- Nehete PN, Nehete BP, Manuri P, Hill L, Palmer JL, Sastry KJ. Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model. Vaccine 23(17-18):2154-9, 2005. PMID: 15755586.
- Starost MF, Hill LR, Nehete PN, Sastry KJ. Extramedullary hematopoiesis in the mandibular lymph node of simian-human immunodeficiency virus-infected rhesus monkeys (Macaca mulatta): a report of three cases. Vet Pathol 41(2):186-90, 2004. PMID: 15017035.
- Hill LR, Nehete PN, Schapiro SJ, Nehete BP, Sastry KJ. SHIV transmission and susceptibility to re-exposure through social contact following vaccination with an HIV synthetic peptide-cocktail: a case study. J Med Primatol 33(1):10-5, 2004. PMID: 15061727.
- Hill LR, Ambrose GA. A simple, inexpensive method to minimize floor-drain obstructions while supporting environmental enrichment in primate facilities. Contemp Top Lab Anim Sci 42(6):42-5, 2003. PMID: 14615961.
- Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Jiang S, Li PL, Baba TW, Montefiori DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Ruprecht RM. Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge. J Med Primatol 31(3):109-19, 2002. PMID: 12190851.
- Hill LR, Coghlan LG, Baze WB. Perineal swellings in two strains of mice. Contemp Top Lab Anim Sci 41(1):51-3, 2002. PMID: 11860260.
- Nehete PN, Chitta S, Hossain MM, Hill L, Bernacky BJ, Baze W, Arlinghaus RB, Sastry KJ. Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model. Vaccine 20(5-6):813-25, 2001. PMID: 11738745.
- Brewer M, Baze W, Hill L, Utzinger U, Wharton JT, Follen M, Khan-Dawood F, Satterfield W. Rhesus macaque model for ovarian cancer chemoprevention. Comp Med 51(5):424-9, 2001. PMID: 11924802.
- Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V, Ferrantelli F, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Chou TC, Andersen J, Ruprecht RM. Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge. J Virol 75(16):7470-80, 2001. PMID: 11462019.
- Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R,Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM. Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?. J Med Primatol 30(4):190-6, 2001. PMID: 11555137.
- Ruprecht RM, Hofmann-Lehmann R, Smith-Franklin BA, Rasmussen RA, Liska V, Vlasak J, Xu W, Baba TW, Chenine AL, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Montefiori DC, McClure HM. Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies. Transfus Clin Biol 8(4):350-8, 2001. PMID: 11642027.
- Brewer M, Utzinger U, Satterfield W, Hill L, Gershenson D, Bast R, Wharton JT, Richards-Kortum R, Follen M. Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention. Cancer Epidemiol Biomarkers Prev 10(8):889-93, 2001. PMID: 11489756.
- Hill LR, Hess KR, Stephens LC, Price RE, Gray KN. Correlation of kidney weight and volume and selected skeletal parameters to sex in the adult rhesus monkey (Macaca mulatta). J Med Primatol 30(1):56-60, 2001. PMID: 11396864.
- Hill LR, Lee DR, Keeling ME. Surgical technique for ambulatory management of airsacculitis in a chimpanzee (Pan troglodytes). Comp Med 51(1):80-4, 2001. PMID: 11926307.
- Hill LR, Bernacky BJ, Hazle JD, Price RE, Keeling ME. What is your diagnosis? Soft-tissue mass outlined with a periosteal reaction overlying the frontal bone. Hematoma of the skull in a rhesus macaque. J Am Vet Med Assoc 216(12):1913-4, 2000. PMID: 10863586.
- Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Lu Y, Wright JE, Chou TC, Ruprecht RM. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med 6(2):200-6, 2000. PMID: 10655110.
- Hill LR, Kille PS, Weiss DA, Craig TM, Coghlan LG. Demodex musculi in the Skin of Transgenic Mice. Contemp Top Lab Anim Sci 38(6):13-18, 1999. PMID: 12086441.
- Hill LR, Hess KR, Stephens LC, Tinkey PT, Price RE. Comparison of kidney weight and volume to selected anatomical parameters in the adult female rhesus monkey (Macaca mulatta). J Med Primatol 28(2):67-72, 1999. PMID: 10431696.
Invited Articles
- Swain J, Hill L. One person is the PI. Lab Anim (NY) 41(8):221, 2012. e-Pub 2012. PMID: 22821043.
- Stanton J, Hill L. Supplementing a training procedure with the use of a cadaver. Response to protocol review scenario: Amendment is reasonable. Lab Anim (NY) 41(5):121, 2012. e-Pub 2012. PMID: 22517089.
- Gibson BW, Hill L. Response to Protocol Review Scenario: not very expedient. Lab Anim (NY) 40(4):103-4, 2011. PMID: 21427684.
- Swain J, Hill LR. Tissues from privately owned dogs. CRC is correct. Lab Anim (NY) 39(3):68-9, 2010. PMID: 20164943.
- Hill LR. Multiple campuses, one IACUC: how many AVs? Delegate authority. Lab Anim (NY) 38(4):112-3, 2009. PMID: 19308056.
- Hill LR. Clinical trial trouble: did the right thing. Lab Anim (NY) 35(6):15-6, 2006. PMID: 16738581.
- Hill LR, Hopp T. Pig surgery: can reduction be a protocol violation?. Lab Anim (NY) 33(6):14, 2004. PMID: 15179429.
Book Chapters
- Hill LR, Tinkey, P. History of mouse cancer models. In: Patient Derived Tumor Xenograft (PDX) Models – Promise, Potential and Practice. One. Elsevier: London, San Diego, Cambridge, Oxford, 15-23, 2017.