Min Jin Ha, PhD
Department of Biostatistics, Division of Basic Sciences
Present Title & Affiliation
Primary Appointment
Assistant Professor (Tenure-track), Department of Biostatistics, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2013 | University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, PHD, Biostatistics |
Experience & Service
Academic Appointments
Regular Member, The University of Texas MD Anderson Cancer Center - UT Health Graduate School of Biomedical Sciences, Houston, TX, 2019 - Present
Honors & Awards
| 2017 | Selected participant, ENAR |
| 2013 | ASA Student Paper Award, American Statistical Association |
| 2013 | BIOS Student Travel Award, University of North Carolina-Chapel Hill |
| 2012 | BIOS Student Travel Award, University of North Carolina-Chapel Hill |
| 2012 | David P. Byar Young Investigator Travel Award, American Statistical Association |
Selected Publications
Peer-Reviewed Articles
- Chun YS, Mizuno T, Cloyd JM, Ha MJ, Omichi K, Tzeng CD, Aloia TA, Ueno NT, Kuerer HM, Barcenas CH, Vauthey JN. Hepatic resection for breast cancer liver metastases: Impact of intrinsic subtypes. Eur J Surg Oncol 46(9):1588-1595, 2020. e-Pub 2020. PMID: 32253074.
- Evrard YA, Srivastava A, Randjelovic J, Doroshow JH, Dean DA, Morris JS, Chuang JH, NCI PDXNet Consortium. Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis. Cancer Res 80(11):2286-2297, 2020. e-Pub 2020. PMID: 32152150.
- Bhattacharyya R, Ha MJ, Liu Q, Akbani R, Liang H, Baladandayuthapani V. Personalized Network Modeling of the Pan-Cancer Patient and Cell Line Interactome. JCO Clin Cancer Inform 4:399-411, 2020. PMID: 32374631.
- Liu Q, Ha MJ, Bhattacharyya R, Garmire L, Baladandayuthapani V. Network-Based Matching of Patients and Targeted Therapies for Precision Oncology. Pac Symp Biocomput 25:623-634, 2020. PMID: 31797633.
- Meraz IM, Majidi M, Feng M, Shao R, Ha MJ, Morris J, Shpall EJ, Roth JA. Efficacy of novel immunogene combinations for Kras and LKB1 mutant NSCLC in a humanized mouse model. American Association for Cancer Research 8(3):615, 2020.
- Ha MJ, Stingo FC, Baladandayuthapani V. Bayesian multi-layered Gaussian graphical models. Journal of the American Statistical Association, 2020.
- Jones RJ, Singh RK, Shirazi F, Wan J, Wang H, Wang X, Ha MJ, Baljevic M, Kuiatse I, Davis RE, Orlowski RZ. Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors. Front Immunol 11:1816, 2020. e-Pub 2020. PMID: 32903557.
- Meraz IM, Majidi M, Meng F, Shao R, Ha MJ, Neri S, Fang B, Lin SH, Tinkey PT, Shpall EJ, Morris J, Roth JA. An improved patient-derived xenograft humanized mouse model for evaluation of lung cancer immune responses. Cancer Immunol Res 7(8):1267-1279, 2019. e-Pub 2019. PMID: 31186248.
- Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer. Clin Cancer Res 25(13):3996-4013, 2019. e-Pub 2019. PMID: 30867218.
- Kim J, Do KA, Ha MJ, Peterson CB. Bayesian inference of hub nodes across multiple networks. Biometrics 75(1):172-182, 2019. e-Pub 2018. PMID: 30051914.
- Ni Y, Stingo FC, Ha MJ, Akbani R, Baladandayuthapani V. Bayesian Hierarchical Varying-sparsity Regression Models with Application to Cancer Proteogenomics. J Am Stat Assoc 114(10):1-13, 2019. e-Pub 2018. PMID: 31178611.
- Ha MJ, Banerjee S, Akbani R, Liang H, Mills GB, Do KA, Baladandayuthapani V. Personalized Integrated Network Modeling of the Cancer Proteome Atlas. Sci Rep 8(1):14924, 2018. e-Pub 2018. PMID: 30297783.
- Class CA, Ha MJ, Baladandayuthapani V, Do KA. iDINGO - Integrative Differential Network Analysis in Genomics with Shiny Application. Bioinformatics 34(7):1243-1245, 2018. e-Pub 2017. PMID: 29194470.
- Yang Q, Chen LS, Ha MJ, Do KA, Neelapu SS, Gandhi V. Idelalisib impacts cell growth through inhibiting translation regulatory mechanisms in mantle cell lymphoma. Clin Cancer Res 23(1):181-192, 2017. e-Pub 2016. PMID: 27342398.
- Hunt K, Karakas C, Ha MJ, Biernacka A, Yi M, Sahin A, Adjapong O, Hortobagyi GN, Bondy M, Thompson P, Cheung KL, Ellis IO, Bacus S, Symmans WF, Do KA, Keyomarsi K. Cytoplasmic Cylin E predicts recurrence in Patients with breast cancer. Clinical Cancer Research 16(2217), 2016.
- Do HJ, Lee YS, Ha MJ, Cho Y, Yi H, Hwang YJ, Hwang GS, Shin MJ. Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification. Endocr J 63(8):691-702, 2016. e-Pub 2016. PMID: 27349182.
- Ha MJ, Sun W, Xie J. PenPC: A two-step approach to estimate the skeletons of high-dimensional directed acyclic graphs. Biometrics 72(1):146-55, 2016. e-Pub 2015. PMID: 26406114.
- Ha MJ, Baladandayuthapani V, Do KA. DINGO: differential network analysis in genomics. Bioinformatics 31(21):3413-20, 2015. e-Pub 2015. PMID: 26148744.
- Ha MJ, Baladandayuthapani V, Do KA. Prognostic gene signature identification using causal structure learning: applications in kidney cancer. Cancer Inform 14(Suppl 1):23-35, 2015. e-Pub 2015. PMID: 25861215.
- Costello JC, Heiser LM, Georgii E, Gönen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K, NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G. A community effort to assess and improve drug sensitivity prediction algorithms. Nat Biotechnol 32(12):1202-12, 2014. e-Pub 2014. PMID: 24880487.
- Ha MJ, Sun W. Partial correlation matrix estimation using ridge penalty followed by thresholding and re-estimation. Biometrics 70(3):765-73, 2014. e-Pub 2014. PMID: 24845967.
- Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou YH, Abdellaoui A, Batista S, Butler C, Chen G, Chen TH, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin A, Tischfield J, Todd L, Tzeng JY, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI. Heritability and genomics of gene expression in peripheral blood. Nat Genet 46(5):430-7, 2014. e-Pub 2014. PMID: 24728292.
- O'Shea SH, Schwarz J, Kosyk O, Ross PK, Ha MJ, Wright FA, Rusyn I. In vitro screening for population variability in chemical toxicity. Toxicol Sci 119(2):398-407, 2011. e-Pub 2010. PMID: 20952501.
- Ha MJ, Sun W. Estimation of high-dimensional directed acyclic graphs with surrogate intervention. Biostatistics. e-Pub 2018. PMID: 30596892.
- Ha MJ, Kim J, Galloway-Pena J, Do K, Peterson CB. Compositional zero-infated network estimation for microbiome data. BMC Bioinformatics.
- Karakas C, Francis AM, Ha MJ, Wingate HF, Meena RA, Yi M, Rasaputra KS, Barrera AMG, Arun B, Do KA, Sahin A, Keyomarsi K, Hunt KK. Cytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer. Ann Surg. e-Pub 2019. PMID: 31436549.
Abstracts
- Meraz IM, Majidi M, Feng M, Shao R, Ha MJ, Morris J, Shpall EJ, Roth JA. Abstract A75: Efficacy of novel immunogene combinations for Kras and LKB1 mutant NSCLC in a humanized mouse model. Cancer Immunology Research, 2020.
- Meraz IM, Majidi M, Feng M, Shao R, Ha MJ, Shpall EJ, Roth JA. TUSC2 immunogene therapy enhances efficacy of immunotherapy and targeted drugs in human non-small cell lung cancer (NSCLC) in humanized mouse models. American Association for Cancer Research, 2020.
- Zhang X, Zhang R, Chen H, Wang L, Ren C, Wu S, Ha MJ, Morris J, Xi Y, Wang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG, Roth JA, Fang B. Novel targeted combination therapies active in KRAS mutant non-small cell lung cancer (NSCLC) identified using patient-derived xenografts (PDX). American Association for Cancer Research, 2020.
- Kettner NM, Bui T, Ha MJ, Eckols TK, Tweardy DJ, Meric-Bernstam F, Hunt KK, Tripathy D, Keyomarsi K. STAT3 as a therapeutic target in estrogen receptor positive breast cancer patients refractory to CDK4/6 inhibition. American Association for Cancer Research, 2020.
- Meraz IM,Majidi M, Meng F, Shao R, Ha MJ, Neri S, Fang B, Lin SH, Tinkey PT, Shpall EJ, Morris J, Roth JA. Development of an improved humanized patient-derived xenograft, Hu-PDX mouse moidel for evaluation of antitumor immune response in lung cancer. AACR Annual Meeting, 2019.
- Thompson PA, Brewster A, Tsavachidis, Armstrong G, Do KA, Ha MJ, Gutierrez C, Symmans F, Bondy M. Cumulative copy number imbalances after neoadjuvant chemotherapy residual breast tumor is an independent predictor of relapse. American Association for Cancer Research, 2019.
- Sun H, Nassif B, Guray M, Ha MJ,Hunt KK, Keyomarsi K, Sahin A. Pathologic Discordance of African American and West African Breast Cancer Populations. United States & Canadian Academy of Pathology's 108th Annual Meeting in National Harbor, Maryland, March 16-21,2019, 2018.
- Hunt KK, Karakas C, Ha MJ, Biernacka A, Yi M, Sahin AA, Adjapong O, Hortobagyi GN, Bondy M, Thompson P, Cheung KL, Ellis IO, Bacus S, Symmans WF, Do KA, Keyomarsi K. Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer. Clin Cancer Res 23(12):2991-3002, 2017. e-Pub 2016. PMID: 27881578.
Book Chapters
- George Tseng. eQTL and Directed Graphical Model. In: Integrating omics data: statistical and computational methods, 2015.
Grant & Contract Support
| Title: | Cancer Center Support Grant - Biostatistics Resource Group (BRG) |
| Funding Source: | NIH/NCI |
| Role: | Biostatistician |
| Title: | Proteomic-based integrated subject-specific networks in cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | University of Texas PDX Development and Trial Center Bioinformatics Core |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | SPORE: Targeting Lung Cancer Vulnerabilities |
| Funding Source: | NIH/NCI Subaward via Un of Tx Southwestern Med Ctr - Dallas |
| Role: | Co-Investigator |
| Title: | Rational Combination Treatment Options to Reverse Resistance in Hormone Receptor Positive Breast Cancer Refractory to Standard Therapy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Cytoplasmic cyclin E is an early event for progression invasive breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Mechanisms and Vulnerabilities of SWI/SNF chromatin remodeling complex mutant lung cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | A Randomized Clinical Trial Platform |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Targeted Proteolysis of Glucocorticoid Receptor (GR) as a Therapeutic Strategy to Enhance Anti-Tumor Immunity |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Title: | MIRA Project 4 - Overcoming PARP inhibitor resistance in patients with breast cancer who have germline BRCA mutations |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | University of Texas PDX Development and Trial Center - Project 3: Optimizing DNA Damage Repair-Targeted Combination Therapy |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |