Peter Friedl, MD, PhD

Peer-Reviewed Articles

1. Weigelin B, Friedl P. T cell-mediated additive cytotoxicity - death by multiple bullets. Trends Cancer 8(12):980-987, 2022. e-Pub 2022. PMID: 35965200.
2. Slaats J, Wagena E, Smits D, Berends AA, Peters E, Bakker GJ, van Erp M, Weigelin B, Adema GJ, Friedl P. Adenosine A2a receptor antagonism restores additive cytotoxicity by cytotoxic T cells in metabolically perturbed tumors. Cancer Immunol Res 10(12):1462-1474, 2022. e-Pub 2022. PMID: 36162129.
3. Wolf K, Friedl P. Steering from the rear. Nat Mater 21(10):1104-1105, 2022. PMID: 36151462.
4. Paindelli C, Casarin S, Wang F, Diaz-Gomez L, Zhang J, Mikos AG, Logothetis CJ, Friedl P, Dondossola E. Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting. J Nucl Med 63(7):1039-1045, 2022. e-Pub 2021. PMID: 34711616.
5. Beunk L, Bakker GJ, van Ens D, Bugter J, Gal F, Svoren M, Friedl P, Wolf K. Actomyosin contractility requirements and reciprocal cell-tissue mechanics for cancer cell invasion through collagen-based channels. Eur Phys J E Soft Matter 45(5):48, 2022. e-Pub 2022. PMID: 35575822.
6. Weiss F, Lauffenburger D, Friedl P. Towards targeting of shared mechanisms of cancer metastasis and therapy resistance. Nat Rev Cancer 22(3):157-173, 2022. e-Pub 2022. PMID: 35013601.
7. Bakker GJ, Weischer S, Ferrer Ortas J, Heidelin J, Andresen V, Beutler M, Beaurepaire E, Friedl P. Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy. Elife 11, 2022. e-Pub 2022. PMID: 35166669.
8. Dondossola E, Friedl P. Host responses to implants by intravital microscopy. Nat Rev Materials 7:6-22, 2022.
9. Te Boekhorst V, Jiang L, Mählen M, Meerlo M, Dunkel G, Durst FC, Yang Y, Levine H, Burgering BMT, Friedl P. Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis. Curr Biol 32(2):412-427.e8, 2022. e-Pub 2021. PMID: 34883047.
10. Haddad TS, Friedl P, Farahani N, Treanor D, Zlobec I, Nagtegaal I. Tutorial: methods for three-dimensional visualization of archival tissue material. Nat Protoc 16(11):4945-4962, 2021. e-Pub 2021. PMID: 34716449.
11. Weigelin B, den Boer AT, Wagena E, Broen K, Dolstra H, de Boer RJ, Figdor CG, Textor J, Friedl P. Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Commun 12(1):5217, 2021. e-Pub 2021. PMID: 34471116.
12. Slaats J, Dieteren CE, Wagena E, Wolf L, Raaijmakers TK, van der Laak JA, Figdor CG, Weigelin B, Friedl P. Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery. Cancer Immunol Res 9(8):926-938, 2021. e-Pub 2021. PMID: 34226201.
13. Van der Meer JMR, Maas RJA, Guldevall K, Klarenaar K, de Jonge PKJD, Evert JSH, van der Waart AB, Cany J, Safrit JT, Lee JH, Wagena E, Friedl P, Önfelt B, Massuger LF, Schaap NPM, Jansen JH, Hobo W, Dolstra H. IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+?progenitor-derived NK cells. Cancer Immunol Immunother. e-Pub 2020. PMID: 33140189.
14. Khalil AA, Ilina O, Vasaturo A, Venhuizen JH, Vullings M, Venhuizen V, Bilos A, Figdor CG, Span PN, Friedl P. Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels. J Cell Biol 219(10), 2020. PMID: 32777015.
15. Deutsch A, Friedl P, Preziosi L, Theraulaz G. Multi-scale analysis and modelling of collective migration in biological systems. Philos Trans R Soc Lond B Biol Sci 375(1807):20190377, 2020. e-Pub 2020. PMID: 32713301.
16. Ilina O, Gritsenko PG, Syga S, Lippoldt J, La Porta CAM, Chepizhko O, Grosser S, Vullings M, Bakker GJ, Starruß J, Bult P, Zapperi S, Käs JA, Deutsch A, Friedl P. Cell-cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion. Nat Cell Biol 22(9):1103-1115, 2020. e-Pub 2020. PMID: 32839548.
17. Wisniewski EO, Mistriotis P, Bera K, Law RA, Zhang J, Nikolic M, Weiger M, Parlani M, Tuntithavornwat S, Afthinos A, Zhao R, Wirtz D, Kalab P, Scarcelli G, Friedl P, Konstantopoulos K. Dorsoventral polarity directs cell responses to migration track geometries. Sci Adv 6(31):eaba6505, 2020. e-Pub 2020. PMID: 32789173.
18. Gonzalez-Beltran AN, Masuzzo P, Ampe C, Bakker GJ, Besson S, Eibl RH, Friedl P, Gunzer M, Kittisopikul M, Dévédec SEL, Leo S, Moore J, Paran Y, Prilusky J, Rocca-Serra P, Roudot P, Schuster M, Sergeant G, Strömblad S, Swedlow JR, van Erp M, Van Troys M, Zaritsky A, Sansone SA, Martens L. Community standards for open cell migration data. Gigascience 9(5), 2020. PMID: 32396199.
19. Gritsenko PG, Atlasy N, Dieteren CEJ, Navis AC, Venhuizen JH, Veelken C, Schubert D, Acker-Palmer A, Westerman BA, Wurdinger T, Leenders W, Wesseling P, Stunnenberg HG, Friedl P. p120-catenin-dependent collective brain infiltration by glioma cell networks. Nat Cell Biol 22(1):97-107, 2020. e-Pub 2020. PMID: 31907411.
20. Haeger A, Alexander S, Vullings M, Kaiser FMP, Veelken C, Flucke U, Koehl GE, Hirschberg M, Flentje M, Hoffman RM, Geissler EK, Kissler S, Friedl P. Collective cancer invasion forms an integrin-dependent radioresistant niche. J Exp Med 217(1), 2020. PMID: 31658985.
21. Friedl P. Rethinking research into metastasis. Elife 8, 2019. e-Pub 2019. PMID: 31845646.
22. Dondossola E, Casarin S, Paindelli C, De-Juan-Pardo EM, Hutmacher DW, Logothetis CJ, Friedl P. Radium 223-mediated zonal cytotoxicity of prostate cancer in bone. J Natl Cancer Inst 111(10):1042-1050, 2019. e-Pub 2019. PMID: 30657953.
23. Beunk L, Brown K, Nagtegaal I, Friedl P, Wolf K. Cancer invasion into musculature: Mechanics, molecules and implications. Semin Cell Dev Biol 93:36-45, 2019. e-Pub 2018. PMID: 30009945.
24. Venhuizen JH, Span PN, van den Dries K, Sommer S, Friedl P, Zegers MM. P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis. Cancers (Basel) 11(10), 2019. e-Pub 2019. PMID: 31569498.
25. Nevozhay D, Weiger M, Friedl P, Sokolov KV. Spatiotemporally controlled nano-sized third harmonic generation agents. Biomed Opt Express 10(7):3301-3316, 2019. e-Pub 2019. PMID: 31360600.
26. Odenthal J, Friedl P, Takes RP. Compatibility of CO2 laser surgery and fluorescence detection in head and neck cancer cells. Head Neck 41(5):1253-1259, 2019. e-Pub 2018. PMID: 30549379.
27. Paindelli C, Navone N, Logothetis CJ, Friedl P, Dondossola E. Engineered bone for probing organotypic growth and therapy response of prostate cancer tumoroids in vitro. Biomaterials 197:296-304, 2019. e-Pub 2019. PMID: 30682644.
28. Venhuizen JH, Sommer S, Span PN, Friedl P, Zegers MM. Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues. Sci Rep 9(1):90, 2019. e-Pub 2019. PMID: 30643202.
29. Huda S, Weigelin B, Wolf K, Tretiakov KV, Polev K, Wilk G, Iwasa M, Emami FS, Narojczyk JW, Banaszak M, Soh S, Pilans D, Vahid A, Makurath M, Friedl P, Borisy GG, Kandere-Grzybowska K, Grzybowski BA. Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo. Nat Commun 9(1):4539, 2018. e-Pub 2018. PMID: 30382086.
30. Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med 10(452), 2018. PMID: 30068572.
31. Gritsenko PG, Friedl P. Adaptive adhesion systems mediate glioma cell invasion in complex environments. J Cell Sci 131(15), 2018. e-Pub 2018. PMID: 29991514.
32. Ilina O, Campanello L, Gritsenko PG, Vullings M, Wang C, Bult P, Losert W, Friedl P. Intravital microscopy of collective invasion plasticity in breast cancer. Dis Model Mech 11(9), 2018. e-Pub 2018. PMID: 29997220.
33. Odenthal J, Rijpkema M, Bos D, Wagena E, Croes H, Grenman R, Boerman O, Takes R, Friedl P. Targeting CD44v6 for fluorescence-guided surgery in head and neck squamous cell carcinoma. Sci Rep 8(1):10467, 2018. e-Pub 2018. PMID: 29992954.
34. Landgraf M, McGovern JA, Friedl P, Hutmacher DW. Rational Design of Mouse Models for Cancer Research. Trends Biotechnol 36(3):242-251, 2018. e-Pub 2018. PMID: 29310843.
35. Van Helvert S, Storm C, Friedl P. Mechanoreciprocity in cell migration. Nat Cell Biol 20(1):8-20, 2018. e-Pub 2017. PMID: 29269951.
36. Khalil AA, Ilina O, Gritsenko PG, Bult P, Span PN, Friedl P. Collective invasion in ductal and lobular breast cancer associates with distant metastasis. Clin Exp Metastasis. e-Pub 2017. PMID: 28894989.
37. Gritsenko P, Leenders W, Friedl P. Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma. Histochem Cell Biol. e-Pub 2017. PMID: 28825130.
38. Veelken C, Bakker GJ, Drell D, Friedl P. Single cell-based automated quantification of therapy responses of invasive cancer spheroids in organotypic 3D culture. Methods. e-Pub 2017. PMID: 28739118.
39. Friedl P, Mayor R. Tuning Collective Cell Migration by Cell-Cell Junction Regulation. Cold Spring Harb Perspect Biol 9(4), 2017. e-Pub 2017. PMID: 28096261.
40. Lehmann S, Te Boekhorst V, Odenthal J, Bianchi R, van Helvert S, Ikenberg K, Ilina O, Stoma S, Xandry J, Jiang L, Grenman R, Rudin M, Friedl P. Hypoxia Induces a HIF-1-Dependent Transition from Collective-to-Amoeboid Dissemination in Epithelial Cancer Cells. Curr Biol 27(3):392-400, 2017. e-Pub 2017. PMID: 28089517.
41. Hofschröer V, Koch KA, Ludwig FT, Friedl P, Oberleithner H, Stock C, Schwab A. Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells. Sci Rep 7:42369, 2017. e-Pub 2017. PMID: 28205573.
42. Odenthal J, Takes R, Friedl P. Plasticity of tumor cell invasion: governance by growth factors and cytokines. Carcinogenesis 37(12):1117-1128, 2016. e-Pub 2016. PMID: 27664164.
43. Dondossola E, Holzapfel BM, Alexander S, Filippini S, Hutmacher DW, Friedl P. Examination of the foreign body response to biomaterials by nonlinear intravital microscopy. Nature Biomedical Engineering, 2016.
44. Te Boekhorst V, Preziosi L, Friedl P. Plasticity of Cell Migration In Vivo and In Silico. Annu Rev Cell Dev Biol 32:491-526, 2016. e-Pub 2016. PMID: 27576118.
45. van Helvert S, Friedl P. Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation. ACS Appl Mater Interfaces 8(34):21946-55, 2016. e-Pub 2016. PMID: 27128771.
46. Weigelin B, Friedl P. Cancer cells: Stemness shaped by curvature. Nat Mater 15(8):827-8, 2016. PMID: 27443907.
47. Weigelin B, Bolaños E, Rodriguez-Ruiz ME, Martinez-Forero I, Friedl P, Melero I. Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?. Cancer Immunol Immunother 65(5):493-7, 2016. e-Pub 2016. PMID: 26970765.
48. Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J. Nuclear envelope rupture and repair during cancer cell migration. Science 352(6283):353-8, 2016. e-Pub 2016. PMID: 27013428.
49. Weigelin B, Bakker GJ, Friedl P. Third harmonic generation microscopy of cells and tissue organization. J Cell Sci 129(2):245-55, 2016. e-Pub 2016. PMID: 26743082.
50. Te Boekhorst V, Friedl P. Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy. Adv Cancer Res 132:209-64, 2016. e-Pub 2016. PMID: 27613134.
51. Haeger A, Wolf K, Zegers MM, Friedl P. Collective cell migration: guidance principles and hierarchies. Trends Cell Biol 25(9):556-66, 2015. e-Pub 2015. PMID: 26137890.
52. Weigelin B, Bolaños E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, Sánchez-Paulete AR, Chen L, Friedl P, Melero I. Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Proc Natl Acad Sci U S A 112(24):7551-6, 2015. e-Pub 2015. PMID: 26034288.
53. Zegers MM, Friedl P. Translating Membrane Tension into Cytoskeletal Action by FBP17. Dev Cell 33(6):628-30, 2015. PMID: 26102599.
54. Chatterji T, Varkaris AS, Parikh NU, Song JH, Cheng CJ, Schweppe RE, Alexander S, Davis JW, Troncoso P, Friedl P, Kuang J, Lin SH, Gallick GE. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells. Oncotarget 6(12):10175-94, 2015. e-Pub 2015. PMID: 25868388.
55. Masuzzo P, Martens L, 2014 Cell Migration Workshop Participants, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaestecker C, Dolznig H, Friedl P, Gaggioli C, Geiger B, Goldberg IG, Horn E, Horwitz R, Kam Z, Le Dévédec SE, Vignjevic DM, Moore J, Olivo-Marin JC, Sahai E, Sansone SA, Sanz-Moreno V, Strömblad S, Swedlow J, Textor J, Van Troys M, Zantl R. An open data ecosystem for cell migration research. Trends Cell Biol 25(2):55-8, 2015. e-Pub 2014. PMID: 25484346.
56. Hoogenkamp HR, Bakker GJ, Wolf L, Suurs P, Dunnewind B, Barbut S, Friedl P, van Kuppevelt TH, Daamen WF. Directing collagen fibers using counter-rotating cone extrusion. Acta Biomater 12:pii: S1742-7061, 2015. e-Pub 2014. PMID: 25462525.
57. Friedl P, Weigelin B. A Swiss Army Knife for CTLs. Immunity 41(6):873-5, 2014. PMID: 25526299.
58. Starke J, Wehrle-Haller B, Friedl P. Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality. Biochem Soc Trans 42(5):1356-1366, 2014. PMID: 25233415.
59. Haeger A, Krause M, Wolf K, Friedl P. Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement. Biochim Biophys Acta 1840(8):2386-95, 2014. e-Pub 2014. PMID: 24721714.
60. Friedl P, Wolf K, Zegers MM. Rho-directed forces in collective migration. Nat Cell Biol 16(3):208-10, 2014. PMID: 24576897.
61. Zegers MM, Friedl P. Rho GTPases in collective cell migration. Small GTPases 5:e28997, 2014. e-Pub 2014. PMID: 25054920.
62. Alexander S, Weigelin B, Winkler F, Friedl P. Preclinical Intravital microscopy of the tumor-stroma interface: invasion, metastasis and therapy response. Curr Opin Cell Biol 25(5):659-71, 2013. e-Pub 2013. PMID: 23896198.
63. Starke J, Maaser K, Wehrle-Haller B, Friedl P . Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: Filopod-mediated extension-relaxation cycles and force anisotropy. Exp Cell Res 19(16):2424-33, 2013. e-Pub 2013. PMID: 23830878.
64. Häger A, Alexander S, Friedl P. Cancer invasion and resistance. EJC Suppl 11(2):291-3, 2013. PMID: 26217149.
65. Wolf K, Te Lindert M, Krause M, Alexander S, Te Riet J, Willis AL, Hoffman RM, Figdor CG, Weiss SJ, Friedl P. Physical limits of cell migration: Control by ECM space and nucler deformation and tuning by proteolysis and traction force. J Cell Biol 201(7):1069-84, 2013. PMID: 23798731.
66. Friedl P, Hubbell J, Livingston D, Mihich E. Twenty-Third Annual Pezcoller Symposium: Engineering influences in cancer research. Cancer Res 72(4):841-4, 2012. e-Pub 2012. PMID: 22237623.
67. Gritsenko PG, Ilina O, Friedl P. Interstitial guidance of cancer invasion. J Pathol 226(2):185-99, 2012. PMID: 22006671.
68. Alexander S, Friedl P. Cancer invasion and resistance: interconnected processes of disease progression and therapy failure. Trends Mol Med 18(1):13-26, 2012. e-Pub 2011. PMID: 22177734.
69. Bakker GJ, Andresen V, Hoffman RM, Friedl P. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods Enzymol 503:109-25, 2012. PMID: 22264531.
70. Friedl P, Locker J, Sahai E, Segall JE. Classifying Collective Cancer Cell Invasion. Nat. Cell Biol 14:777-783, 2012.
71. Bonetto F, Srinivas M, Weigelin B, Cruz LJ, Heerschap A, Friedl, P, Figdor, CG, de Vries IJ. A large-scale (19) F MRI-based cell migration assay to optimize cell therapy. NMR Biomed 25:1095-1103, 2012.
72. Weigelin B, Bakker, GJ, Friedl P. Intravital third harmonic generation microscopy of collective melanoma cell invasion: principles of interface guidance and microvesicle dynamics. Intravital 1:32-43, 2012.
73. Friedl P, Sahai SJ, Weiss KM, Yamada. New dimensions in cell migration. Nat. Rev. Mol. Cell Biol 13:743-747, 2012. e-Pub 2012. PMID: 23072889.
74. Wolf K, Friedl P. Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. Trends Cell Biol 21(12):736-44, 2011. e-Pub 2011. PMID: 22036198.
75. Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147(5):992-1009, 2011. PMID: 22118458.
76. Weigelin B, Krause M, Friedl P. Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment. Immunol Lett 138(1):19-21, 2011. e-Pub 2011. PMID: 21333682.
77. Ilina O, Bakker GJ, Vasaturo A, Hofmann RM, Friedl P. Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion. Phys Biol 8(1):015010, 2011. e-Pub 2011. PMID: 21301056.
78. Friedl P, Wolf K, Lammerding J. Nuclear mechanics during cell migration. Curr Opin Cell Biol 23(1):55-64, 2011. e-Pub 2010. PMID: 21109415.
79. Dommerholt J, Schmidt S, Temming R, Hendriks LJ, Rutjes FP, van Hest JC, Lefeber DJ, Friedl P, van Delft FL. Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. Angew Chem Int Ed Engl 49(49):9422-5, 2010. PMID: 20857472.
80. Weigelin B, Friedl P. A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes. Biochem Pharmacol 80(12):2087-91, 2010. e-Pub 2010. PMID: 20849829.
81. Khalil AA, Friedl P. Determinants of leader cells in collective cell migration. Integr Biol (Camb) 2(11-12):568-74, 2010. e-Pub 2010. PMID: 20886167.
82. Storim J, Brocker EB, Friedl P. A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling. Eur J Immunol 40(10):2741-50, 2010. PMID: 20821730.
83. Friedl P, Zallen JA. Dynamics of cell-cell and cell-matrix interactions in morphogenesis, regeneration and cancer. Curr Opin Cell Biol 22(5):557-9, 2010. e-Pub 2010. PMID: 20850290.
84. Kampik D, Ralla B, Keller S, Hirschberg M, Friedl P, Geerling G. Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci 51(8):3929-34, 2010. e-Pub 2010. PMID: 20207972.
85. Belletti B, Pellizzari I, Berton S, Fabris L, Wolf K, Lovat F, Schiappacassi M, D'Andrea S, Nicoloso MS, Lovisa S, Sonego M, Defilippi P, Vecchione A, Colombatti A, Friedl P, Baldassarre G. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol 30(9):2229-40, 2010. e-Pub 2010. PMID: 20194624.
86. Meierjohann S, Hufnagel A, Wende E, Kleinschmidt MA, Wolf K, Friedl P, Gaubatz S, Schartl M. MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9:201, 2010. e-Pub 2010. PMID: 20667128.
87. Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol 188(1):11-9, 2010. e-Pub 2009. PMID: 19951899.
88. Schmidt S, Friedl P. Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res 339(1):83-92, 2010. e-Pub 2009. PMID: 19921267.
89. Friedl P. To adhere or not to adhere?. Nat Rev Mol Cell Biol 11(1):3, 2010. PMID: 20050305.
90. Wolf K, Alexander S, Schacht V, Coussens LM, von Andrian UH, van Rheenen J, Deryugina E, Friedl P. Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol 20(8):931-41, 2009. e-Pub 2009. PMID: 19682592.
91. Ilina O, Friedl P. Mechanisms of collective cell migration at a glance. J Cell Sci 122(Pt 18):3203-8, 2009. PMID: 19726629.
92. Imle A, Polzer B, Alexander S, Klein CA, Friedl P. Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry A 75(7):562-8, 2009. PMID: 19405114.
93. Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10(7):445-57, 2009. PMID: 19546857.
94. Friedl P, Wolf K. Proteolytic interstitial cell migration: a five-step process. Cancer Metastasis Rev 28(1-2):129-35, 2009. PMID: 19153672.
95. Friedl P. Painting a picture of cancer immunology. Interview by Caitlin Sedwick. J Cell Biol 185(2):180-1, 2009. PMID: 19380873.
96. Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol 20(1):54-62, 2009. e-Pub 2009. PMID: 19324541.
97. Wolf K, Friedl P. Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis 26(4):289-98, 2009. e-Pub 2008. PMID: 18600304.
98. Friedl P. Dynamic imaging of cancer invasion and metastasis: principles and preclinical applications. Clin Exp Metastasis 26(4):269-271, 2009. PMID: 19229643.
99. Berton S, Belletti B, Wolf K, Canzonieeri V, Lovat F, Vecchione A, Colombatti A, Friedl P, Baldassarre G. The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol 29:5031-45, 2009. PMID: 19596789.
100. Friedl P,. p27kip1 Affects cell migration and invasion by regulating the switch from mesenchymal to amoeboid motility. Clin Ep Metastasis 26:867, 2009.
101. Alexander S, Koehl GE, Hirschberg M, Geissler EK, Friedl P. Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol 130(6):1147-54, 2008. e-Pub 2008. PMID: 18987875.
102. Friedl P, Wolf K. Tube travel: the role of proteases in individual and collective cancer cell invasion. Cancer Res 68(18):7247-9, 2008. PMID: 18794108.
103. Friedl P, Weigelin B. Interstitial leukocyte migration and immune function. Nat Immunol 9(9):960-9, 2008. PMID: 18711433.
104. Hartmann A, Quist J, Hamm H, Brocker EB, Friedl P. Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier. Dermatol Surg 34(7):922-9, 2008. PMID: 18384617.
105. Muessel MJ, Scott KS, Friedl P, Bradding P, Wardlaw AJ. CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment. J Immunol 180(12):8354-60, 2008. PMID: 18523302.
106. Belletti B, Nicoloso MS, Schiappacassi M, Berton S, Lovat F, Wolf K, Canzonieri V, D'Andrea S, Zucchetto A, Friedl P, Colombatti A, Baldassarre G. Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell 19(5):2003-13, 2008. e-Pub 2008. PMID: 18305103.
107. Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol 9(8):893-904, 2007. e-Pub 2007. PMID: 17618273.
108. Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M. Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 100(6):856-63, 2007. e-Pub 2007. PMID: 17303760.
109. Cam H, Griesmann H, Beitzinger M, Hofmann L, Beinoraviciute-Kellner R, Sauer M, Huttinger-Kirchhof N, Oswald C, Friedl P, Gattenlohner S, Burek C, Rosenwald A, Stiewe T. p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell 10(4):281-93, 2006. PMID: 17045206.
110. Wolf K, Friedl P. Molecular mechanisms of cancer cell invasion and plasticity. Br J Dermatol 154 Suppl 1:11-5, 2006. PMID: 16712711.
111. Hartmann A, Boukamp P, Friedl P. Confocal reflection imaging of 3D fibrin polymers. Blood Cells Mol Dis 36(2):191-3, 2006. e-Pub 2006. PMID: 16488165.
112. Friedl P. Cell fusion: new mechanisms for plasticity in cancer?. Lancet Oncol 6(12):916-918, 2005. PMID: 16321755.
113. Friedl P, den Boer AT, Gunzer M. Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol 5(7):532-45, 2005. PMID: 15999094.
114. Wolf K, Friedl P. Functional imaging of pericellular proteolysis in cancer cell invasion. Biochimie 87(3-4):315-20, 2005. PMID: 15781318.
115. Mayer C, Maaser K, Daryab N, Zänker KS, Bröcker EB, Friedl P. Release of cell fragments by invading melanoma cells. Eur J Cell Biol 83(11-12):709-15, 2004. PMID: 15679115.
116. Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S. A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood 104(9):2801-9, 2004. e-Pub 2004. PMID: 15256430.
117. Friedl P, Storim J. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol 14(10):557-67, 2004. PMID: 15450978.
118. Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci 117(Pt 20):4863-71, 2004. e-Pub 2004. PMID: 15340013.
119. Friedl P. Dynamic imaging of cellular interactions with extracellular matrix. Histochem Cell Biol 122(3):183-90, 2004. e-Pub 2004. PMID: 15258769.
120. Friedl P. Dynamic imaging of the immune system. Curr Opin Immunol 16(4):389-93, 2004. PMID: 15245730.
121. Schröder M, Matischak K, Friedl P. Serum- and protein-free media formulations for the Chinese hamster ovary cell line DUKXB11. J Biotechnol 108(3):279-92, 2004. PMID: 15006429.
122. Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol 16(1):14-23, 2004. PMID: 15037300.
123. Friedl P, Bröcker EB. Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking. Methods Mol Biol 239:77-90, 2004. PMID: 14573911.
124. Friedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 48(5-6):441-9, 2004. PMID: 15349818.
125. Wolf K, Müller R, Borgmann S, Bröcker EB, Friedl P. Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood 102(9):3262-9, 2003. e-Pub 2003. PMID: 12855577.
126. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3(5):362-74, 2003. PMID: 12724734.
127. Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, Strongin AY, Bröcker EB, Friedl P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160(2):267-77, 2003. e-Pub 2003. PMID: 12527751.
128. Friedl P, Wolf K. Proteolytic and non-proteolytic migration of tumour cells and leucocytes. Biochem Soc Symp(70):277-85, 2003. PMID: 14587300.
129. Friedl P, Bröcker EB. TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells. Immunol Rev 186:83-9, 2002. PMID: 12234364.
130. Hegerfeldt Y, Tusch M, Bröcker EB, Friedl P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res 62(7):2125-30, 2002. PMID: 11929834.
131. Friedl P, Borgmann S, Brocker EB. Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement. J Leukoc Biol 70(4):491-509, 2001. PMID: 11590185.
132. Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J. Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes. Exp Cell Res 267(2):233-42, 2001. PMID: 11426942.
133. Friedl P, Gunzer M. Interaction of T cells with APCs: the serial encounter model. Trends Immunol 22(4):187-91, 2001. PMID: 11274922.
134. Gunzer M, Schafer A, Borgmann S, Grabbe S, Zanker KS, Brocker EB, Kampgen E, Friedl P. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13(3):323-32, 2000. PMID: 11021530.
135. Gunzer M, Friedl P, Niggemann B, Brocker EB, Kampgen E, Zanker KS. Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines. J Leukoc Biol 67(5):622-9, 2000. PMID: 10811001.
136. Friedl P, Brocker EB. The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci 57(1):41-64, 2000. PMID: 10949580.
137. Friedl P, Brocker EB. T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations. Dev Immunol 7(2-4):249-66, 2000. PMID: 11097216.
138. Maaser K, Wolf K, Klein CE, Niggemann B, Zanker KS, Brocker EB, Friedl P. Functional hierarchy of simultaneously expressed adhesion receptors: integrin alpha2beta1 but not CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagen matrices. Mol Biol Cell 10(10):3067-79, 1999. PMID: 10512851.
139. Friedl P, Zanker KS, Brocker EB. Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech 43(5):369-78, 1998. PMID: 9858334.
140. Nikolai G, Niggemann B, Werner M, Zanker KS, Friedl P. Direct and rapid induction of migration in human CD4+ T lymphocytes within three-dimensional collagen matrices mediated by signalling via CD3 and/or CD2. Immunology 95(1):62-8, 1998. PMID: 9767458.
141. Friedl P, Entschladen F, Conrad C, Niggemann B, Zanker KS. CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion. Eur J Immunol 28(8):2331-43, 1998. PMID: 9710211.
142. Friedl P, Brocker EB, Zanker KS. Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells. Cell Adhes Commun 6(2-3):225-36, 1998. PMID: 9823473.
143. Entschladen F, Niggemann B, Zanker KS, Friedl P. Differential requirement of protein tyrosine kinases and protein kinase C in the regulation of T cell locomotion in three-dimensional collagen matrices. J Immunol 159(7):3203-10, 1997. PMID: 9317118.
144. Nikolai G, Friedl P, Werner M, Niggemann B, Zanker KS. Effect of a mistletoe extract (Iscador QuFrF) on viability and migratory behavior of human peripheral CD4+ and CD8+ T lymphocytes in three-dimensional collagen lattices. In Vitro Cell Dev Biol Anim 33(9):710-6, 1997. PMID: 9358287.
145. Niggemann B, Maaser K, Lu H, Kroczek R, Zanker KS, Friedl P. Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice. Cancer Lett 118(2):173-80, 1997. PMID: 9459207.
146. Friedl P, Maaser K, Klein CE, Niggemann B, Krohne G, Zanker KS. Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of alpha2 and beta1 integrins and CD44. Cancer Res 57(10):2061-70, 1997. PMID: 9158006.
147. Nikolai G, Friedl P, Werner M, Zanker KS. Donor-dependent and dose-dependent variation in the induction of T lymphocyte locomotion in a three-dimensional collagen matrix system by a mistletoe preparation (Iscador). Anticancer Drugs 8 Suppl (1):S61-4, 1997. PMID: 9179371.
148. Gunzer M, Kampgen E, Brocker EB, Zanker KS, Friedl P. Migration of dendritic cells in 3D-collagen lattices. Visualisation of dynamic interactions with the substratum and the distribution of surface structures via a novel confocal reflection imaging technique. Adv Exp Med Biol 417:97-103, 1997. PMID: 9286344.
149. Friedl P, Noble PB, Walton PA, Laird DW, Chauvin PJ, Tabah RJ, Black M, Zanker KS. Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. Cancer Res 55(20):4557-60, 1995. PMID: 7553628.
150. Friedl P, Noble PB, Zanker KS. T lymphocyte locomotion in a three-dimensional collagen matrix. Expression and function of cell adhesion molecules. J Immunol 154(10):4973-85, 1995. PMID: 7537296.
151. Friedl P, Noble PB, Shields ED, Zanker KS. Locomotor phenotypes of unstimulated CD45RAhigh and CD45ROhigh CD4+ and CD8+ lymphocytes in three-dimensional collagen lattices. Immunology 82(4):617-24, 1994. PMID: 7835926.
152. Friedl P|, Noble PB, Zanker KS. Lymphocyte locomotion in three-dimensional collagen gels. Comparison of three quantitative methods for analysing cell trajectories. J Immunol Methods 165(2):157-65, 1993. PMID: 7901283.
153. Friedl P, Konig B, Konig W. Effects of mucoid and non-mucoid pseudomonas aeruginosa isolates from cystic fibrosis patients on inflammatory mediator release from human polymorphonuclear granulocytes and rat mast cells. Immunology 76(1):86-94, 1992. PMID: 1321094.
154. Konig B, Friedl P, Pedersen SS, Konig W. Alginate--its role in neutrophil responses and signal transduction towards mucoid Pseudomonas aeruginosa bacteria. Int Arch Allergy Immunol 99(1):98-106, 1992. PMID: 1336422.

Other Articles

1. Friedl P, Wolf K Fast Moving Front article selection from the field of Molecular Biology & Genetics for the month of March 2011: "Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion":893-904, 2007.

Book Chapters

1. Friedl P. In: At the tumor-stroma interface: imaging collective cancer cell invasion and resistance, 2009.
2. Friedl P, Wolf K, von Andrian UH, Harms G. Curr Protoc Cell Biol. In: Biological second and third harmonic generation microscopy, Unit 4.15, 2007.
3. Rimke I, Buttner E, Andresen V, Friedl P. In: Infrared multiphoton microscopy beyond 1 micon: system design and biomedical applications: Washington, 2006.
4. Friedl P, Wolf K. In: Diversite cellulaire et moleculaire des strategies de migration cellulaires: Paris, 1-6, 2003.
5. Friedl P, Masser K, Brocker EB. In: Molecular mechanisms of melanoma cell motility and tissue invasion: Netherlands, 2002.
6. Friedl P. In: Extrazellulare Matris und Immuneregularion: Springer, 55-59, 2002.
7. Friedl P, Brocker EB. In: Biological confocal reflection microscopy: reconstruction of three-dimensional extracellular matrix, cell migration, and matrix reorganization: Florida, 9-21, 2001.
8. Friedl P, Brocker EB. In: Cancer cell interaction with the extracellular matrix involved in tissue invasion and cancer cell migration: Motility mechanisms beyond the single cell paradign: Heidelberg, 7-18, 1997.
9. Friedl P, Niggemann B, Brocker EB, Zanker KS. In: Konfrontation humaner T Lymphozyten mit autologen Tymorexplataten in 3-D Kollagenmatrices in vitro: Heidelberg, 237-242, 1997.
10. Nikolai G, Friedl P, Nobel PB, Wener M, Niggemann B, Zanker KS. In: Eine Methode zur Untersuchung des Einflusses von Mistelpraparaten auf die Motilitat humaner T-Lymphozyten in einem in vitro 3-D Kollagenmatrixsystem: Stuttgart, 1996.