Philipp Y Maximov, M.D., Ph.D., MBA
Department of Breast Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Breast Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2010 | Russian State Medical University, Moscow, RUS, PHD, Medical Biochemistry and Molecular Biology |
| 2006 | Russian State Medical University, Moscow, RUS, MD, Medical Biochemistry |
Postgraduate Training
| 2011-2014 | Research Fellowship, Susan G. Komen International Postdoctoral Fellow, Lombardi Comprehensive Cancer Center, Washington, DC |
Experience & Service
Academic Appointments
Susan G. Komen International Postdoctoral Fellow, Lombardi Comprehensive Cancer Center, Washington, DC, 2011 - 2014
Ph.D. Student, Fox Chase Cancer Center, Philadelphia, PA, 2006 - 2010
M.S. Student, Fox Chase Cancer Center, Philadelphia, PA, 2005 - 2006
Scientific Technician, Department of Molecular and Medical Pharmacology of the Medico-Biological Faculty, Russian State Medical University, Moscow, 2004 - 2005
Scientific Technician, Department of Medical Microbiology and Virology of the Medico-Biological Faculty, Russian State Medical University, Moscow, 2000 - 2004
Administrative Appointments/Responsibilities
Mentor/Lecturer, Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, 2013 - Present
Guest Lecturer, Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC, 2012 - Present
Guest Lecturer, Russian State Medical University, Moscow, 2010 - Present
Selected Publications
Peer-Reviewed Articles
- Maximov PY, McDaniel RE, Fernandes DJ, Korostyshevskiy VR, Bhatta P, Mürdter TE, Flockhart DA, Jordan VC. Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes. Br J Pharmacol 171(24):5624-35, 2014. PMID: 25073551.
- Craig Jordan V, McDaniel R, Agboke F, Maximov PY. The evolution of nonsteroidal antiestrogens to become selective estrogen receptor modulators. Steroids 90:3-12, 2014. e-Pub 2014. PMID: 24949934.
- Molloy ME, White BE, Gherezghiher T, Michalsen BT, Xiong R, Patel H, Zhao H, Maximov PY, Jordan VC, Thatcher GR, Tonetti DA. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther 13(11):2515-26, 2014. e-Pub 2014. PMID: 25205655.
- Maximov PY, McDaniel RE, Fernandes DJ, Bhatta P, Korostyshevskiy VR, Curpan RF, Jordan VC. Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients. J Natl Cancer Inst 106(10), 2014. e-Pub 2014. PMID: 25258390.
- Maximov PY, Fernandes DJ, McDaniel RE, Myers CB, Curpan RF, Jordan VC. Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells. J Med Chem 57(11):4569-83, 2014. e-Pub 2014. PMID: 24805199.
- Maximov PY, Lee TM, Jordan VC. The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice. Curr Clin Pharmacol 8(2):135-55, 2013. PMID: 23062036.
- Sengupta S, Obiorah I, Maximov PY, Curpan R, Jordan VC. Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol 169(1):167-78, 2013. PMID: 23373633.
- McDaniel RE, Maximov PY, Jordan VC. Estrogen-mediated mechanisms to control the growth and apoptosis of breast cancer cells: a translational research success story. Vitam Horm 93:1-49, 2013. PMID: 23810002.
- Sweeney EE, McDaniel RE, Maximov PY, Fan P, Jordan VC. Models and Mechanisms of Acquired Antihormone Resistance in Breast Cancer: Significant Clinical Progress Despite Limitations. Horm Mol Biol Clin Investig 9(2):143-163, 2012. PMID: 23308083.
- Kulagina EV, Efimov BA, Maximov PY, Kafarskaia LI, Chaplin AV, Shkoporov AN. Species composition of Bacteroidales order bacteria in the feces of healthy people of various ages. Biosci Biotechnol Biochem 76(1):169-71, 2012. e-Pub 2012. PMID: 22232251.
- Maximov PY, Sengupta S, Lewis-Wambi JS, Kim HR, Curpan RF, Jordan VC. The Conformation of the Estrogen Receptor Directs Estrogen-Induced Apoptosis in Breast Cancer: A Hypothesis. Horm Mol Biol Clin Investig 5(1):27-34, 2011. PMID: 21660224.
- Maximov PY, Myers CB, Curpan RF, Lewis-Wambi JS, Jordan VC. Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen. J Med Chem 53(8):3273-83, 2010. PMID: 20334368.
- Maximov PY, Lewis-Wambi JS, Jordan VC. The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis. Curr Signal Transduct Ther 4(2):88-102, 2009. PMID: 19809537.
- Shkoporov AN, Kafarskaia LI, Afanas'ev SS, Smeianov VV, Kirillov MIu, Postnikova EA, Maximov PY, Khokhlova EV, Efimov BA. [A molecular-and-genetic analysis of species and strain diversity of bifidobacteria in early childhood]. Vestn Ross Akad Med Nauk(1):45-50, 2006. PMID: 16496956.
Book Chapters
- McDaniel RE, Maximov PY, Jordan VC. Estrogen-mediated mechanisms to control the growth and apoptosis of breast cancer cells: a translational research success story. In: Vitamins and Hormones. Academic Press: London, 1-49, 2013.
- Maximov PY, Jordan VC. Estrogen-Induced Apoptosis in Breast Cancer Cells: Translation to Clinical Relevance. In: Targeting New Pathways and Cell Death in Breast Cancer. In Tech Publishing: Rijeka, 3-22, 2012.
Books (edited and written)
- Maximov PY, McDaniel RE, Jordan VC. Tamoxifen- a pioneering medicine. Springer Publishing: Basel, 2013.