Prahlad T. Ram, Ph.D.
Department of Systems Biology, Division of VP, Research
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Systems Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Quantitative Sciences Program, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 1997 | Tulane University, New Orleans, LA, USA, PHD, Structural and Cellular Biology |
| 1991 | Rutgers University, Camden, NJ, USA, BA, Biology |
Postgraduate Training
| 1997-2001 | Postdoctoral Fellowship, Mount Sinai School of Medicine, New York, NY |
Experience & Service
Academic Appointments
Assistant Professor, Department of Systems Biology 1, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2003 - 2009
Assistant Professor, Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY, 2002 - 2003
Instructor, Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY, 2001 - 2002
Other Appointments/Responsibilities
Co-Director, Biostatistics, Bioinformatics, and Systems Biology Program, GSBS, Houston, TX, 2013 - Present
Steering Committee, NIH Theoretical and Computational Neuroscience Training Grant, Houston, TX, 2005 - Present
Faculty, Gulf Coast Consortia/Keck Center Pharmacoinformatics Training Grant, Houston, TX, 2005 - Present
Faculty, UT Graduate School of Biomedical Sciences, Houston, TX, 2004 - Present
Faculty, Gulf Coast Center for Computational Cancer Research, Houston, TX, 2004 - Present
Institutional Committee Activities
Member, UTMDACC Graduate Education Committee, 2012 - Present
Member, MD/PhD Advisory Committee, 2011 - Present
Member, Recruiting Council, 2011 - Present
Chair, Post-doctoral advisory committee, 2010 - 2011
Chair, GSBS Admissions Committee, 2010 - 2011
Chair, GSBS Admissions Committee, 2010 - 2011
Member, GSBS Executive Committee, 2010 - Present
Admissions Committee, Vice-Chair, GSBS, 2009 - 2010
Admission Committee, GSBS, 2008 - 2009
Member, Keck Center NIH Theoretical and Computational Neuroscience Training Grant, 2005 - Present
Member, GSBS Poster Award Committee Annual Trainee Day, 2005 - Present
Member, UT M.D. Anderson Department of Molecular Therapeutics Faculty Search Committee, 2005 - 2006
Member, UT M.D. Anderson Division of Cancer Medicine Exemplary Employee Award Committee, 2004 - Present
Member, UT M.D. Anderson Alfred G. Knudson Outstanding Dissertation Award Committee, 2004 - Present
Member, UT M.D. Anderson Postdoctoral Fellows Advisory Committee, 2004 - 2011
Selected Publications
Peer-Reviewed Articles
- Seviour EG, Sehgal V, Mishra D, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Lee JS, Sood AK, Kim MP, Mills GB, Ram PT. Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p. Oncogene 36(10):1339-1350, 2017. e-Pub 2016. PMID: 27669434.
- Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T, Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metab 24(5):685-700, 2016. PMID: 27829138.
- Tetzlaff MT, Singh RR, Seviour EG, Curry JL, Hudgens CW, Bell D, Wimmer DA, Ning J, Czerniak BA, Zhang L, Davies MA, Prieto VG, Broaddus RR, Ram P, Luthra R, Esmaeli B. Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma. J Pathol 240(1):84-95, 2016. PMID: 27287813.
- Chaluvally-Raghavan P, Jeong KJ, Pradeep S, Silva AM, Yu S, Liu W, Moss T, Rodriguez-Aguayo C, Zhang D, Ram P, Liu J, Lu Y, Lopez-Berestein G, Calin GA, Sood AK, Mills GB. Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. Cell Rep 15(7):1493-504, 2016. e-Pub 2016. PMID: 27160903.
- Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun 7:11169, 2016. e-Pub 2016. PMID: 27041221.
- Kang Y, Nagaraja AS, Armaiz-Pena GN, Dorniak PL, Hu W, Rupaimoole R, Liu T, Gharpure KM, Previs RA, Hansen JM, Rodriguez-Aguayo C, Ivan C, Ram P, Sehgal V, Lopez-Berestein G, Lutgendorf SK, Cole SW, Sood AK. Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. Clin Cancer Res 22(7):1713-24, 2016. e-Pub 2015. PMID: 26581245.
- Seviour EG, Sehgal V, Lu Y, Luo Z, Moss T, Zhang F, Hill SM, Liu W, Maiti SN, Cooper L, Azencot R, Lopez-Berestein G, Rodriguez-Aguayo C, Roopaimoole R, Pecot CV, Pecot C, Sood AK, Mukherjee S, Gray JW, Mills GB, Ram PT. Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. Oncogene 35(6):691-701, 2016. e-Pub 2015. PMID: 25639871.
- Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife 5:e10250, 2016. e-Pub 2016. PMID: 26920219.
- Chiu HS, Llobet-Navas D, Yang X, Chung WJ, Ambesi-Impiombato A, Iyer A, Kim HR, Seviour EG, Luo Z, Sehgal V, Moss T, Lu Y, Ram P, Silva J, Mills GB, Califano A, Sumazin P. Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks. Genome Res 25(2):257-67, 2015. PMID: 25378249.
- Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB. Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell 26(6):863-79, 2014. PMID: 25490449.
- Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 26(1):77-91, 2014. PMID: 25026212.
- Hu W, Liu T, Ivan C, Sun Y, Huang J, Mangala LS, Miyake T, Dalton HJ, Pradeep S, Rupaimoole R, Previs RA, Han HD, Bottsford-Miller J, Zand B, Kang Y, Pecot CV, Nick AM, Wu SY, Lee JS, Sehgal V, Ram P, Liu J, Tucker SL, Lopez-Berestein G, Baggerly KA, Coleman RL, Sood AK. Notch3 pathway alterations in ovarian cancer. Cancer Res 74(12):3282-93, 2014. PMID: 24743243.
- Werner HM, Mills GB, Ram PT. Cancer Systems Biology: a peek into the future of patient care?. Nat Rev Clin Oncol 11(3):167-76, 2014. PMID: 24492837.
- Matsuo K, Nishimura M, Komurov K, Shahzad MM, Ali-Fehmi R, Roh JW, Lu C, Cody DD, Ram PT, Loizos N, Coleman RL, Sood AK. Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma. Gynecol Oncol 132(1):166-75, 2014. PMID: 24183729.
- Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram P, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. J Hepatol, 2014. PMID: 24583248.
- Roh JW, Huang J, Hu W, Yang X, Jennings NB, Sehgal V, Sohn BH, Han HD, Lee SJ, Thanapprapa D, Bottsford-Miller J, Zand B, Dalton HJ, Previs RA, Davis AN, Matsuo K, Lee JS, Ram PT, Coleman R, Sood AK. Biological effects of platelet-derived growth factor receptor α blockade in uterine cancer. Clin Cancer Res, 2014. PMID: 24634380.
- Iadevaia S, Nakhleh LK, Azencott R, Ram PT. Mapping network motif tunability and robustness in the design of synthetic signaling circuits. PLoS One 9(3):e91743, 2014. PMID: 24642504.
- Akbani R, Ng PK, Werner HM, Shahmoradgoli M, Zhang F, Ju Z, Liu W, Yang JY, Yoshihara K, Li J, Ling S, Seviour EG, Ram PT, Minna JD, Diao L, Tong P, Heymach JV, Hill SM, Dondelinger F, Städler N, Byers LA, Meric-Bernstam F, Weinstein JN, Broom BM, Verhaak RG, Liang H, Mukherjee S, Lu Y, Mills GB. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun 5:3887, 2014. PMID: 24871328.
- Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol 10:728, 2014. PMID: 24799285.
- Sehgal V, Ram PT. Network Motifs in JNK Signaling. Genes Cancer 4(9-10):409-413, 2013. PMID: 24349639.
- Slingluff CL, Petroni GR, Molhoek KR, Brautigan DL, Chianese-Bullock KA, Shada AL, Smolkin ME, Olson WC, Gaucher A, Chase CM, Grosh WW, Weiss GR, Wagenseller AG, Olszanski AJ, Martin L, Shea SM, Erdag G, Ram P, Gershenwald JE, Weber MJ. Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47). Clin Cancer Res 19(13):3611-20, 2013. PMID: 23620404.
- Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, Wu S, Han HD, Shah MY, Rodriguez-Aguayo C, Bottsford-Miller J, Liu Y, Kim SB, Unruh A, Gonzalez-Villasana V, Huang L, Zand B, Moreno-Smith M, Mangala LS, Taylor M, Dalton HJ, Sehgal V, Wen Y, Kang Y, Baggerly KA, Lee JS, Ram PT, Ravoori MK, Kundra V, Zhang X, Ali-Fehmi R, Gonzalez-Angulo AM, Massion PP, Calin GA, Lopez-Berestein G, Zhang W, Sood AK. Tumour angiogenesis regulation by the miR-200 family. Nat Commun 4:2427, 2013. PMID: 24018975.
- Ram PT, Mendelsohn J, Mills GB. Bioinformatics and systems biology. Mol Oncol 6(2):147-54, 2012. PMID: 22377422.
- Komurov K, Dursun S, Erdin S, Ram PT. NetWalker: a contextual network analysis tool for functional genomics. BMC Genomics 13(1):282, 2012. PMID: 22732065.
- Komurov K, Tseng JT, Muller M, Seviour EG, Moss TJ, Yang L, Nagrath D, Ram PT. The glucose-deprivation response network counteracts EGFR signaling in lapatinib resistant cells. Mol Syst Biol 8(596):596, 2012. PMID: 22864381.
- Matsuo K, Nishimura M, Bottsford-Miller JN, Huang J, Komurov K, Armaiz-Pena GN, Shahzad MM, Stone RL, Roh JW, Sanguino AM, Lu C, Im DD, Rosenshien NB, Sakakibara A, Nagano T, Yamasaki M, Enomoto T, Kimura T, Ram PT, Schmeler KM, Gallick GE, Wong KK, Frumovitz M, Sood AK. Targeting Src in Mucinous Ovarian Carcinoma. Clin Cancer Res 17(16):5367-5378, 2011. PMID: 21737505.
- Lu Y, Muller M, Smith D, Dutta B, Komurov K, Iadevaia S, Ruths D, Tseng JT, Yu S, Yu Q, Nakhleh L, Balazsi G, Donnelly J, Schurdak M, Morgan-Lappe S, Fesik S, Ram PT, Mills GB. Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling. Oncogene, 2011. PMID: 21666717.
- Nick AM, Stone RL, Armaiz-Pena G, Ozpolat B, Tekedereli I, Graybill WS, Landen CN, Villares G, Vivas-Mejia P, Bottsford-Miller J, Kim HS, Lee JS, Kim SM, Baggerly KA, Ram PT, Deavers MT, Coleman RL, Lopez-Berestein G, Sood AK. Silencing of p130Cas in Ovarian Carcinoma: A Novel Mechanism for Tumor Cell Death. J Natl Cancer Inst, 2011. PMID: 21957230.
- Gopal YN, Deng W, Woodman SE, Komurov K, Ram P, Smith PD, Davies MA. Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells. Cancer Res 70(21):8736-47, 2010. PMID: 20959481.
- Iadevaia S, Lu Y, Morales FC, Mills GB, Ram PT. Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Res 70(17):6704-14, 2010. PMID: 20643779.
- Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A 107(35):15449-54, 2010. PMID: 20713713.
- Komurov K, White MA, Ram PT. Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data. PLoS Comput Biol 6(8), 2010. PMID: 20808879.
- Komurov K, Ram PT. Patterns of human gene expression variance show strong associations with signaling network hierarchy. BMC Syst Biol 4(1):154, 2010. PMID: 21073694.
- Ruths D, Nakhleh L, Ram PT. Rapidly Exploring Structural and Dynamic Properties of Signaling Networks Using PathwayOracle. BMC Syst Biol 2(1):76, 2008. PMID: 18713463.
- Muller M, Obeyesekere M, Mills GB, Ram PT. Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R. FASEB J 22(5):1393-403, 2008. PMID: 18171696.
- Ruths D, Muller M, Tseng JT, Nakhleh L, Ram PT. The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks. PLoS Comput Biol 4(2):e1000005, 2008. PMID: 18463702.
- Aaronson DS, Muller M, Neves SR, Chung WC, Jayaram G, Iyengar R, Ram PT. An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells. Mol Cell Endocrinol 270(1-2):50-6, 2007. PMID: 17374439.
- Ruths D, Tseng J-T, Nakhleh L, Ram PT. DeNovo Signaling Pathway Predictions based on protein-protein interaction, targeted therapy and protein microarray analysis. LNCS 4532:108-118, 2007.
- Ruths DA, Nakhleh L, Iyengar MS, Reddy SA, Ram PT. Hypothesis generation in signaling networks. J Comput Biol 13(9):1546-57, 2006. PMID: 17147477.
- He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 280(39):33426-34, 2005. PMID: 16046413.
- Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science 309(5737):1078-83, 2005. PMID: 16099987.
- Campagne F, Neves S, Chang CW, Skrabanek L, Ram PT, Iyengar R, Weinstein H. Quantitative information management for the biochemical computation of cellular networks. Science Signaling 2004(248):pl11, 2004. PMID: 15340175.
- Bhalla US, Ram PT, Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297(5583):1018-23, 2002. PMID: 12169734.
- Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, Hill SM. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett 179(2):141-50, 2002. PMID: 11888668.
- Kiefer T, Ram PT, Yuan L, Hill SM. Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells. Breast Cancer Res Treat 71(1):37-45, 2002. PMID: 11859872.
- Obrink B, Sawa H, Scheffrahn I, Singer BB, Sigmundsson K, Sundberg U, Heymann R, Beauchemin N, Weng G, Ram P, Iyengar R. Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells. Ann N Y Acad Sci 971:597-607, 2002. PMID: 12438192.
- Dai J, Ram PT, Yuan L, Spriggs LL, Hill SM. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin. Mol Cell Endocrinol 176(1-2):111-20, 2001. PMID: 11369450.
- Ram PT, Yuan L, Dai J, Kiefer T, Klotz DM, Spriggs LL, Hill SM. Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. J Pineal Res 28(4):210-8, 2000. PMID: 10831156.
- Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science 287(5450):142-4, 2000. PMID: 10615050.
- Eck KM, Yuan L, Duffy L, Ram PT, Ayettey S, Chen I, Cohn CS, Reed JC, Hill SM. A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells. Br J Cancer 77(12):2129-37, 1998. PMID: 9649124.
- Ram PT, Kiefer T, Silverman M, Song Y, Brown GM, Hill SM. Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. Mol Cell Endocrinol 141(1-2):53-64, 1998. PMID: 9723886.
- Chen J, Bander JA, Santore TA, Chen Y, Ram PT, Smit MJ, Iyengar R. Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proc Natl Acad Sci U S A 95(5):2648-52, 1998. PMID: 9482941.
- Worrad DM, Ram PT, Schultz RM. Regulation of gene expression in the mouse oocyte and early preimplantation embryo: developmental changes in Sp1 and TATA box-binding protein, TBP. Development 120(8):2347-57, 1994. PMID: 7925035.
- Temeles GL, Ram PT, Rothstein JL, Schultz RM. Expression patterns of novel genes during mouse preimplantation embryogenesis. Mol Reprod Dev 37(2):121-9, 1994. PMID: 7545925.
- Ram PT, Schultz RM. Reporter gene expression in G2 of the 1-cell mouse embryo. Dev Biol 156(2):552-6, 1993. PMID: 8462750.
- Wu S, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire M, Nagaraja AS, Miyake T, Rupaimoole R, Pecot C, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi H, Previs R, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han H-D, Su C, Kim J-H, Dalton H, Kowali C, Keyomarsi K, McMillan N, Overwijk W , Liu J, Lee J-S, Baggerly K, Lopez-Berestein G, Ram PT, NawrotB, Sood A. Evoking potent RNAi response in cancer using novel 2'-OMe-phosphorodithioated modified siRNAs. Nat Commun:12;5:3459. PMID: 24619206.
Invited Articles
- Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4(12):988-1004, 2005. PMID: 16341064.
- Neves SR, Ram PT, Iyengar R. The hetrotrimeric G protein pathways. Science 296(5573):1636-9, 2002. PMID: 12040175.
- Ram PT, Iyengar R. G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene 20(13):1601-6, 2001. PMID: 11313907.
- Hill SM, Teplitzky S, Ram PT, Kiefer T, Blask DE, Spriggs LL, Eck KM. Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. Adv Exp Med Biol 460:345-62, 1999. PMID: 10810532.
Other Articles
- Ram PT, Iyengar R G protein connections map for Gas, Gaq, Ga12, Ga13 signaling networks. Science Signaling, 2002.
Book Chapters
- Muller M, Ram PT. Sytems Biology of the MAPK1,2 network. In: Systems Biology and Signaling Networks. Springer Press: New York, 2010.
- Ram PT, Jordan DJ, Iyengar R. Effectors of Gao signaling. In: Handbook of Cellular Signaling. Academic Press, 605-607, 2004.
- Ram PT. Overexpression of tightly regulated proteins: protein phosphatase 2A overexpression in NIH 3T3 cells. In: Methods Enzymol, 551-5, 2002.
- Ram PT, Iyengar R. Signal Transduction. In: McGraw-Hill Encyclopedia of Science and Technology 9th Edition. McGraw-Hill, 2002.
- Hill SM, Ram PT, Molis TM, Spriggs LL. Melatonin on the neoplastic cellular level. In: Melatonin in Neoplastic and Psychiatric Disorders. American Psychiatric Association Press, Washington DC, 191-242, 1998.
Grant & Contract Support
| Title: | Computational and experimental analysis of the MC1R SNPs in regulating cAMP and the MAPK and Stat3 network, and the development of Gas peptides to inhibit melanoma proliferation |
| Funding Source: | Sharp Foundation for Melanoma ResearchComp |
| Role: | Principal Investigator |
| Title: | New faculty start up funding |
| Funding Source: | UT M.D. Anderson Cancer Center |
| Role: | Principal Investigator-MDACC |
| Title: | Functional proteomic analysis of signaling networks and response to targeted therapy |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Determinants of Signaling Network Regulation in Combinatorial Target Therapies |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | MC1R, Ras, andB-raf mutations in theetiology of melanoma |
| Funding Source: | MDACC Melanoma NIH NCI SPORE Development Grant |
| Role: | Principal Investigator-MDACC |
| Title: | |
| Funding Source: | Pharmacoinformatics Training Grant |
| Role: | Co-Investigator |
| Title: | |
| Funding Source: | Pharmacoinformatics Training Grant |
| Role: | Co-Investigator |
| Title: | Determinants of Signaling Network Regulation in Combinatorial Target Therapies |
| Funding Source: | MDACC Bridge Funding |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | AstraZeneca-MDACC Grant |
| Role: | Co-Investigator |
| Title: | |
| Funding Source: | Pharmacoinformatics Training Grant |
| Role: | Principal Investigator-MDACC |
| Title: | |
| Funding Source: | Pharmacoinformatics Training Grant |
| Role: | Principal Investigator-MDACC |
| Title: | Bayesian models for cancer prognosis by integrating diverse types of data |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | |
| Funding Source: | Gulf Coast Consortia/WM Keck Foundation Collaborative Activity Seed Grand |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | AstraZeneca-MDACC Grant |
| Role: | Co-Investigator |
| Title: | Model-based predictions of response to RTK pathway therapies |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Overcoming acquired lapatininb resistance |
| Funding Source: | Susan G. Komen Breast Cancer Foundation |
| Role: | Principal Investigator |
| Title: | miR-24 As a Therapeutic Agent in Ovarian Cancer |
| Funding Source: | Blanton-Davis Ovarian Cancer Research Program |
| Role: | Principal Investigator-MDACC |
| Title: | Influence of extrinsic perturbations on cell regulatory networks and physiology |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Understanding and targeting tumor microenvironment in prostate cancer to inhibit tumor progression and castration resistance |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Investigator |
| Title: | Extrinsic Perturbations of Cell Physiology and Associated Regulatory Networks |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Systems Identification of miRNA for cancer therapeutics |
| Funding Source: | UTMDACC Bridge Funding |
| Role: | Principal Investigator |
| Title: | Targeting BRCAness and P13Kness in Ovarian Cancer |
| Funding Source: | V Foundation (Yao Fund Supplement to Ovarian Spore) |
| Role: | Principal Investigator |
| Title: | Functional proteomics platform |
| Funding Source: | Adelson Medical Research Foundation |
| Role: | Collaborator |
| Title: | Biological annotation of TCGA data |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | Strategic Alliance: Examining adaptive resistance mechanisms and differential response across genotypes that could lead to rational drug combinations |
| Funding Source: | Karus Therapeutics Ltd |
| Role: | Collaborator |
| Title: | Combinatorial Adaptive Resistance Therapy in Breast Cancer |
| Funding Source: | Susan G. Komen Breast Cancer Foundation |
| Role: | Collaborator |
| Title: | The Mechanisms of Anti-Cancer Activity of COTI-2 |
| Funding Source: | Critical Outcome Technologies |
| Role: | Collaborator |
| Title: | Novel Therapeutic Opportunities in Ovarian Cancer |
| Funding Source: | Adelson Medical Research Foundation |
| Role: | Collaborator |
| Title: | Uncovering Role of Exosomes in Regulating Pancreatic Cancer Cell Metabolism |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |