Shao-Cong Sun, Ph.D.
Department of Immunology, Division of Basic Sciences
About Dr. Sun
Dr. Shao-Cong Sun is the Director of the Center for Inflammation and Cancer, the Moshe Talpaz Endowed Chair in Immunology, and Professor and Deputy Chair in the Department of Immunology at the University of Texas MD Anderson Cancer Center. His research concerns signal transduction in immune and inflammatory responses, with a major focus on the regulation of inflammatory T cell activation and differentiation. His lab has made a number of major contributions to the field, including pioneer work in NF- κ B signaling and seminal findings on the role of ubiquitination in regulation of T-cell activation and development of autoimmune inflammatory diseases. Dr. Sun was among the first to demonstrate I- κ B α inducible degradation as the fundamental mechanism of NF- κ B activation, and his laboratory also pioneered the discovery of the noncanonical NF- κ B pathway and demonstration of its regulatory mechanism. Dr. Sun’s laboratory has also made seminal findings regarding the role of ubiquitination in the regulation of T cell development, homeostasis, and activation and characterized a number of E3 ubiquitin ligases and deubiquitinases. An important part of his ongoing research is to dissect the ubiquitin-dependent signaling pathways in the regulation of T-cell activation and tolerance in animal models of inflammatory diseases and tumor microenvironment. Dr. Sun is a highly decorated immunologist. In 2015 received the Dallas/Fort Worth Living Legend Faculty Achievement Award and in 2017 was elected a fellow of the American Association for the Advancement of Science (AAAS).
Present Title & Affiliation
Primary Appointment
Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Moshe Talpaz Endowed Chair in Immunology, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Center for Inflammation and Cancer (CIC), The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1992 | Stockholm University, Stockholm, SWE, PhD, Microbiology |
| 1989 | Stockholm University, Stockholm, SWE, MS, Microbiology |
| 1982 | Hebei University, Baoding City, CHN, BS, Microbiology and Biochemistry |
Postgraduate Training
| 1992-1994 | Postdoctoral Research Fellowship, The Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA |
Experience & Service
Academic Appointments
Faculty, The University of Texas Health Science Center Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2016 - Present
Administrative Appointments/Responsibilities
Deputy Department Chair, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - Present
Associate Director, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - Present
Other Appointments/Responsibilities
Member, Graduate School of Biomedical Sciences (GSBS) Immunology Graduate Program Steering Committee, MD Anderson UTHealth Graduate School, Houston, TX, 2017 - Present
Institutional Committee Activities
Member, The University of Texas MD Anderson Cancer Center Promotion and Tenure Committee, 2012 - 2015
Member, Program Income Advisory Committee for the Research Animal Support Facility - Houston, 2011 - Present
Member, Immunology Chair Search Committee, 2011 - 2011
Member, Cancer Prevention & Research Institute of Texas (CPRIT) Scholar Program, 2011 - Present
Member, Committee of Genetically Engineered Mouse Facility (GEMF), 2010 - Present
Member, Institutional Research Grant (IRG) Study Section Review Committee, 2009 - 2018
Senator, The University of Texas MD Anderson Cancer Center Faculty Senate, 2009 - 2012
Member, Animal Advisory Committee (South Campus), 2008 - Present
Endowed Positions
M.R. Evelyn Hudson Foundation Endowed Professorship in Diagnostic Radiology, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2013
Honors & Awards
| 2017 | Elected Fellow, American Association for the Advancement of Science (AAAS) |
| 2015 | The Dallas/Fort Worth Living Legend Faculty Achievement Award in Basic Research, The University of Texas MD Anderson Cancer Center |
| 2013 | Endowed Chair, The University of Texas MD Anderson Cancer Center |
| 2012 | Best Boss Award, The University of Texas MD Anderson Cancer Center |
| 2010 | Endowed Professorship, The University of Texas MD Anderson Cancer Center |
| 2006 | Distinguished Professor Award, Penn State University |
| 1998 | Hinkle Society Outstanding Junior Investigator Award, Penn State University |
| 1996 | Junior Scholar Award, American Society of Hematology (ASH) |
| 1994 | Scholar Award, American Foundation for AIDS Research (amfAR) |
Selected Publications
Peer-Reviewed Articles
- Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis, exerting antitumor efficacy. Cancer Immunol Res 8(7):952-965, 2020. e-Pub 2020. PMID: 32265228.
- Luo H, Li G, Wang B, Tian B, Gao J, Zou J, Shi S, Zhu S, Peng BH, Adam A, Martinez A, Hein K, Winkelmann ER, Mahmoud Y, Zhou X, Shan C, Rossi S, Weaver S, Barrett ADT, Sun SC, Zhang W, Shi PY, Wu P, Wang T. Peli1 signaling blockade attenuates congenital zika syndrome. PLoS Pathog 16(6):e1008538, 2020. e-Pub 2020. PMID: 32544190.
- Zhu L, Li Y, Xie X, Zhou X, Gu M, Jie Z, Ko CJ, Gao T, Hernandez BE, Cheng X, Sun SC. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nat Cell Biol 21(12):1604-1614, 2019. e-Pub 2019. PMID: 31792381.
- Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming. Nat Immunol 20(7):879-889, 2019. e-Pub 2019. PMID: 31182807.
- Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC. Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res 29(6):474-485, 2019. e-Pub 2019. PMID: 31086255.
- Yang J, Zhang S, Zhang L, Xie X, Wang H, Jie Z, Gu M, Yang JY, Cheng X, Sun SC. Lymphatic endothelial cells regulate B-cell homing to lymph nodes via a NIK-dependent mechanism. Cell Mol Immunol 16(2):165-177, 2019. e-Pub 2018. PMID: 29503445.
- Xie X, Jin J, Zhu L, Jie Z, Li Y, Zhao B, Cheng X, Li P, Sun SC. Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction. Cell Biosci 9:5, 2019. e-Pub 2019. PMID: 30622699.
- Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun 10(1):448, 2019. e-Pub 2019. PMID: 30683885.
- Meng X, Liu X, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu X, Zhou P, Huang X, Wei L, Yang W, Xu C. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature 564(7734):130-135, 2018. e-Pub 2018. PMID: 30487606.
- Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. J Clin Invest 128(11):4980-4991, 2018. e-Pub 2018. PMID: 30247157.
- Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nat Immunol 19(11):1224-1235, 2018. e-Pub 2018. PMID: 30250187.
- Yu X, Teng XL, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L, Liu Z, Sun SC, Zou Q. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med 215(9):2463-2476, 2018. e-Pub 2018. PMID: 30115741.
- Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F. Immune cell production of interleukin 17 induces stem cell features of pancreatic intraepithelial neoplasia cells. Gastroenterology 155(1):210-223.e3, 2018. e-Pub 2018. PMID: 29604293.
- Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, Shi J, Zhao S, Zhang B, Cheng X, Sun SC. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun 9(1):2812, 2018. e-Pub 2018. PMID: 30022064.
- Li D, Tavana O, Sun SC, Gu W. Peli1 modulates the subcellular localization and activity of Mdmx. Cancer Res 78(11):2897-2910, 2018. e-Pub 2018. PMID: 29523541.
- Alturki NA, McComb S, Ariana A, Rijal D, Korneluk RG, Sun SC, Alnemri E, Sad S. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. Cell Death Dis 9(6):592, 2018. e-Pub 2018. PMID: 29789521.
- Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 deubiquitinase and a potential therapeutic target in breast cancer. Cell Rep 23(3):823-837, 2018. PMID: 29669287.
- Jiang Y, Liu Y, Lu H, Sun SC, Jin W, Wang X, Dong C. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28. Nat Commun 9(1):1424, 2018. e-Pub 2018. PMID: 29651155.
- Chen N, Ling ZX, Jin TT, Li M, Zhao S, Zheng LS, Xi X, Wang LL, Chen YY, Shen YL, Zhang LP, Sun SC. Altered profiles of gut microbiota in klebsiella pneumoniae-induced pyogenic liver abscess. Curr Microbiol, 2018. e-Pub 2018. PMID: 29637226.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A 115(10):E2311-E2319, 2018. e-Pub 2018. PMID: 29463696.
- Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun 9(1):1136, 2018. e-Pub 2018. PMID: 29555915.
- Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A 114(45):11944-11949, 2017. e-Pub 2017. PMID: 29078411.
- Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, Singh D, Ritthipichai K, Hailemichael Y, Hoang ON, Qin H, Schluns KS, Wang T, Overwijk WW, Sun SC, Bernatchez C, Kwak LW, Neelapu SS, Nurieva R. Absence of grail promotes CD8(+) T cell anti-tumour activity. Nat Commun 8(1):239, 2017. e-Pub 2017. PMID: 28798332.
- Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC*, Wei W* (*Co-corresponding authors). TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature 545(7654):365-369, 2017. e-Pub 2017. PMID: 28489822. *Co-Corresponding Authors.
- Xiao Y, Zou Q, Xie X, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 214(5):1493-1507, 2017. e-Pub 2017. PMID: 28356390.
- Lereim RR, Oveland E, Xiao Y, Torkildsen Ø, Wergeland S, Myhr KM, Sun SC, Berven FS. The brain proteome of the ubiquitin ligase Peli1 knock-out mouse during experimental autoimmune encephalomyelitis. J Proteomics Bioinform 9(9):209-219, 2016. e-Pub 2016. PMID: 27746629.
- Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal 9(447):ra94, 2016. e-Pub 2016. PMID: 27678219.
- Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol 97(3):261-70, 2016. e-Pub 2016. PMID: 26660446.
- Jin J, Xie X, Xiao Y, Hu H, Zou Q, Cheng X, Sun SC. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nat Immunol 17(3):259-68, 2016. e-Pub 2016. PMID: 26808229.
- Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med 213(3):399-414, 2016. e-Pub 2016. PMID: 26903241.
- Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL, Xu C. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 531(7596):651-5, 2016. e-Pub 2016. PMID: 26982734.
- Li Y, Wang H, Zhou X, Xie X, Chen X, Jie Z, Zou Q, Hu H, Zhu L, Cheng X, Brightbill HD, Wu LC, Wang L, Sun SC. Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses. Sci Rep 6:22115, 2016. e-Pub 2016. PMID: 26912039.
- Zou Q, Jin J, Xiao Y, Zhou X, Hu H, Cheng X, Kazimi N, Ullrich SE, Sun SC. T cell intrinsic USP15 deficiency promotes excessive IFN-γ production and an immunosuppressive tumor microenvironment in MCA-induced fibrosarcoma. Cell Rep 13(11):2470-9, 2015. e-Pub 2015. PMID: 26686633.
- Chang JH, Hu H, Sun SC. Survival and maintenance of regulatory T cells require the kinase TAK1. Cell Mol Immunol 12(5):572-9, 2015. e-Pub 2015. PMID: 25891214.
- Romano S, Xiao Y, Nakaya M, D'Angelillo A, Chang M, Jin J, Hausch F, Masullo M, Feng X, Romano MF, Sun SC. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma. Nucleic Acids Res 43(14):6983-93, 2015. e-Pub 2015. PMID: 26101251.
- Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Jie Z, Xie X, Li JY, Cheng X, Sun SC. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med 212(8):1323-36, 2015. e-Pub 2015. PMID: 26195727.
- Wang H, Lai Y, Mathis BJ, Wang W, Li S, Qu C, Li B, Shao L, Song H, Janicki JS, Sun SC, Wang XL, Tang D, Cui T. Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. J Mol Cell Cardiol 84:143-53, 2015. e-Pub 2015. PMID: 25935309.
- Zhao Y, Zhang Y, Song HB, Wu F, Wang XL, Sun SC, Cui TX, Tang DQ. Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model. Genet Mol Res 14(2):5970-8, 2015. e-Pub 2015. PMID: 26125796.
- Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, Ge W, Cheng X, Sun SC. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun 6:5930, 2015. e-Pub 2015. PMID: 25565375.
- Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A, Zal T, Sun SC. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun 6:6074, 2015. e-Pub 2015. PMID: 25606824.
- Xiao Y, Jin J, Zou Q, Hu H, Cheng X, Sun SC. Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS. Cell Biosci 5:34, 2015. e-Pub 2015. PMID: 26131354.
- Ren T, Takahashi Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. Oncogene 34(3):334-45, 2015. e-Pub 2013. PMID: 24362528.
- Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun 5:5798, 2014. e-Pub 2014. PMID: 25503582.
- Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J. CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res 24(11):1342-53, 2014. e-Pub 2014. PMID: 25342559.
- Yu J, Zhou X, Nakaya M, Jin W, Cheng X, Sun SC. T cell-intrinsic function of the noncanonical NF-κB pathway in the regulation of GM-CSF expression and experimental autoimmune encephalomyelitis pathogenesis. J Immunol 193(1):422-30, 2014. e-Pub 2014. PMID: 24899500.
- Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med 211(8):1689-702, 2014. e-Pub 2014. PMID: 24980047.
- Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol 15(6):562-70, 2014. e-Pub 2014. PMID: 24777531.
- Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 40(5):692-705, 2014. e-Pub 2014. PMID: 24792914.
- Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. Immunity 40(3):342-54, 2014. PMID: 24656046.
- Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A 111(6):2158-63, 2014. e-Pub 2014. PMID: 24469800.
- Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med 211(1):137-51, 2014. e-Pub 2013. PMID: 24378539.
- Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade. Sci Signal 6(306):ra110, 2013. e-Pub 2013. PMID: 24345681.
- Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 19(5):595-602, 2013. e-Pub 2013. PMID: 23603814.
- Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal 6(275):ra35, 2013. e-Pub 2013. PMID: 23674823.
- Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature 494(7437):371-4, 2013. e-Pub 2013. PMID: 23334419.
- Zhou XF, Yu J, Chang M, Zhang M, Zhou D, Cammas F, Sun SC. TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A 109(49):20083-8, 2012. e-Pub 2012. PMID: 23169648.
- Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling. Nat Immunol 13(11):1101-9, 2012. e-Pub 2012. PMID: 23023393.
- Ren T, Dong W, Takahashi Y, Xiang D, Yuan Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. J Biol Chem 287(41):34683-93, 2012. e-Pub 2012. PMID: 22891252.
- Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol 189(2):786-92, 2012. e-Pub 2012. PMID: 22706086.
- Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol 13(5):481-90, 2012. PMID: 22484734.
- Zhang M, Lee AJ, Wu X, Sun SC. Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol 8(6):502-4, 2011. e-Pub 2011. PMID: 21946435.
- Chiou SH, Shahi P, Wagner RT, Hu H, Lapteva N, Seethammagari M, Sun SC, Levitt JM, Spencer DM. The E3 ligase c-Cbl regulates dendritic cell activation. EMBO Rep 12(9):971-9, 2011. e-Pub 2011. PMID: 21799517.
- Hu H, Wu X, Jin W, Chang M, Cheng X, Sun SC. Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proc Natl Acad Sci U S A 108(31):12827-32, 2011. e-Pub 2011. PMID: 21768353.
- Wu X, Zhang M, Sun SC. Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax. Cell Biosci 1:27, 2011. e-Pub 2011. PMID: 21824392.
- Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol 12(10):1002-9, 2011. e-Pub 2011. PMID: 21874024.
- Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal 4(161):ra11, 2011. e-Pub 2011. PMID: 21343618.
- Sun SC. Non-canonical NF-κB signaling pathway. Cell Res 21(1):71-85, 2011. e-Pub 2010. PMID: 21173796.
- Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer Cell 18(3):268-81, 2010. PMID: 20832754.
- Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A 107(34):15193-8, 2010. e-Pub 2010. PMID: 20696914.
- Lee AJ, Zhou X, Chang M, Hunzeker J, Bonneau RH, Zhou D, Sun SC. Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J 29(9):1600-12, 2010. e-Pub 2010. PMID: 20224552.
- Lee AJ, Wu X, Cheng H, Zhou X, Cheng X, Sun SC. CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem 285(21):15696-703, 2010. e-Pub 2010. PMID: 20233721.
- Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32(5):670-80, 2010. e-Pub 2010. PMID: 20493730.
- Tang H, Park S, Sun SC, Trumbly R, Ren G, Tsung E, Yeung KC. RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett 584(4):662-8, 2010. e-Pub 2009. PMID: 20043910.
- Arima K, Watanabe N, Hanabuchi S, Chang M, Sun SC, Liu YJ. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal 3(105):ra4, 2010. e-Pub 2010. PMID: 20086239.
- Wu X, Yamamoto M, Akira S, Sun SC. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. Proc Natl Acad Sci U S A 106(49):20836-41, 2009. e-Pub 2009. PMID: 19926860.
- Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10(10):1089-95, 2009. e-Pub 2009. PMID: 19734906.
- Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM, Lee HC, Ziegler SF, Courtney AN, Miller CJ, Sun SC, Liu YJ, Sastry KJ. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A 106(39):16776-81, 2009. e-Pub 2009. PMID: 19805372.
- Jin W, Zhou XF, Yu J, Cheng X, Sun SC. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 113(26):6603-10, 2009. e-Pub 2009. PMID: 19411637.
- Zhang M, Jin W, Zhou X, Yu J, Lee AJ, Sun SC. Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cell Signal 21(4):559-66, 2009. e-Pub 2008. PMID: 19159680.
- Chang M, Lee AJ, Fitzpatrick L, Zhang M, Sun SC. NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol 182(5):3131-8, 2009. PMID: 19234210.
- Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC. Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem 283(27):18621-6, 2008. e-Pub 2008. PMID: 18467330.
- Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 118(5):1858-66, 2008. PMID: 18382763.
- Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 13(5):705-16, 2007. PMID: 17981138.
- Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 204(6):1475-85, 2007. e-Pub 2007. PMID: 17548520.
- Wu X, Sun SC. Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep 8(5):510-5, 2007. e-Pub 2007. PMID: 17363973.
- Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M, Sun SC. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem 282(21):15884-93, 2007. e-Pub 2007. PMID: 17392286.
- Harhaj NS, Sun SC, Harhaj EW. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem 282(6):4185-92, 2007. e-Pub 2006. PMID: 17145747.
- Liang C, Zhang M, Sun SC. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal 18(8):1309-17, 2006. e-Pub 2005. PMID: 16303288.
- Babu G, Waterfield M, Chang M, Wu X, Sun SC. Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem 281(20):14041-7, 2006. e-Pub 2006. PMID: 16565081.
- Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol 290(4):C1146-59, 2006. e-Pub 2005. PMID: 16306129.
- Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun SC. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 7(4):411-7, 2006. e-Pub 2006. PMID: 16501569.
- Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC. Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochem Biophys Acta 1763(2):174-81, 2006. e-Pub 2006. PMID: 16448710.
- Reiley W, Zhang M, Wu X, Granger E, Sun SC. Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol 25(10):3886-95, 2005. PMID: 15870263.
- Harhaj EW, Harhaj NS, Grant C, Mostoller K, Alefantis T, Sun SC, Wigdahl B. Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology 333(1):145-58, 2005. PMID: 15708600.
- Morrison MD, Reiley W, Zhang M, Sun SC. An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway. J Biol Chem 280(11):10018-24, 2005. e-Pub 2005. PMID: 15644327.
- Reiley W, Zhang M, Sun SC. Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem 279(53):55161-7, 2004. e-Pub 2004. PMID: 15496400.
- Waterfield M, Jin W, Reiley W, Zhang M, Sun SC. IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol 24(13):6040-8, 2004. PMID: 15199157.
- Xiao G, Fong A, Sun SC. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 279(29):30099-105, 2004. e-Pub 2004. PMID: 15140882.
- Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem 279(25):26243-50, 2004. e-Pub 2004. PMID: 15084608.
- Cvijic ME, Xiao G, Sun SC. Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J Immunol Methods 278(1-2):293-304, 2003. PMID: 12957416.
- Liao G, Sun SC. Regulation of NF-kappaB2/p100 processing by its nuclear shuttling. Oncogene 22(31):4868-74, 2003. PMID: 12894228.
- Waterfield MR, Zhang M, Norman LP, Sun SC. NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell 11(3):685-94, 2003. PMID: 12667451.
- Fong A, Zhang M, Neely J, Sun SC. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem 277(43):40697-702, 2002. e-Pub 2002. PMID: 12185077.
- Fong A, Sun SC. Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J Biol Chem 277(25):22111-4, 2002. e-Pub 2002. PMID: 11994270.
- Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M, Sun SC. Retroviral oncoprotein tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20(23):6805-15, 2001. PMID: 11726516.
- Rivera-Walsh I, Waterfield M, Xiao G, Fong A, Sun SC. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J Biol Chem 276(44):40385-8, 2001. e-Pub 2001. PMID: 11553609.
- Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-9, 2001. PMID: 11520989.
- Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7(2):401-9, 2001. PMID: 11239468.
- Xiao G, Harhaj EW, Sun SC. Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J Biol Chem 275(44):34060-7, 2000. PMID: 10906125.
- Xiao G, Sun SC. Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. Oncogene 19(45):5198-203, 2000. PMID: 11064457.
- Rivera-Walsh I, Cvijic ME, Xiao G, Sun SC. The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death. J Biol Chem 275(33):25222-30, 2000. PMID: 10837465.
- Xiao G, Sun SC. Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J Biol Chem 275(28):21081-5, 2000. PMID: 10887201.
- Harhaj EW, Good L, Xiao G, Uhlik M, Cvijic ME, Rivera-Walsh I, Sun SC. Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene 19(11):1448-56, 2000. PMID: 10723136.
- Harhaj EW, Sun SC. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Mol Cell Biol 19(10):7088-95, 1999. PMID: 10490645.
- Harhaj EW, Sun SC. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem 274(33):22911-4, 1999. PMID: 10438454.
- Lamberti A, Romano MF, Agosti V, Garbi C, Sun SC, Bond HM, Bonelli P, Turco MC, Venuta S. Regulation of cell survival in CD95-induced T cell apoptosis: role of NF-kappa B/Rel transcription factors. Apoptosis 4(3):179-86, 1999. PMID: 14634280.
- Sun SC, Maggirwar SB, Harhaj EW, Uhlik M. Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells. Oncogene 18(7):1401-9, 1999. PMID: 10050877.
- Harhaj EW, Good L, Xiao G, Sun SC. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 18(6):1341-9, 1999. PMID: 10022816.
- Harhaj EW, Sun SC. IkappaB kinases serve as a target of CD28 signaling. J Biol Chem 273(39):25185-90, 1998. PMID: 9737979.
- Zhang MY, Harhaj EW, Bell L, Sun SC, Miller BA. Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors. Blood 92(4):1225-34, 1998. PMID: 9694711.
- Rivera I, Harhaj EW, Sun SC. Involvement of NF-AT in type I human T-cell leukemia virus Tax-mediated Fas ligand promoter transactivation. J Biol Chem 273(35):22382-8, 1998. PMID: 9712859.
- Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem 273(33):21132-6, 1998. PMID: 9694868.
- Zhang MY, Sun SC, Bell L, Miller BA. NF-kappaB transcription factors are involved in normal erythropoiesis. Blood 91(11):4136-44, 1998. PMID: 9596659.
- Turco MC, Romano MF, Lamberti A, Petrella A, Bisogni R, Sun SC, Ferrone S, Bonelli P, Cerra M, Venuta S. Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies. Tissue Antigens 50(1):1-7, 1997. PMID: 9243748.
- Chen F, Lu Y, Kuhn DC, Maki M, Shi X, Sun SC, Demers LM. Calpain contributes to silica-induced I kappa B-alpha degradation and nuclear factor-kappa B activation. Arch Biochem Biophys 342(2):383-8, 1997. PMID: 9186501.
- Maggirwar SB, Harhaj EW, Sun SC. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors. Mol Cell Biol 17(5):2605-14, 1997. PMID: 9111330.
- Chen F, Sun S, Kuhn DC, Gaydos LJ, Shi X, Lu Y, Demers LM. Involvement of NF-kappaB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages. Am J Physiol 272(4 Pt 1):L779-86, 1997. PMID: 9142954.
- Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, Demers LM. Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun 231(1):99-102, 1997. PMID: 9070227.
- Harhaj EW, Sun SC. The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences. J Biol Chem 272(9):5409-12, 1997. PMID: 9038140.
- Good L, Maggirwar SB, Harhaj EW, Sun SC. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. J Biol Chem 272(3):1425-8, 1997. PMID: 8999806.
- Harhaj EW, Maggirwar SB, Good L, Sun SC. CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. Mol Cell Biol 16(12):6736-43, 1996. PMID: 8943328.
- Mandal M, Maggirwar SB, Sharma N, Kaufmann SH, Sun SC, Kumar R. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem 271(48):30354-9, 1996. PMID: 8939996.
- Good L, Maggirwar SB, Sun SC. Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element. EMBO J 15(14):3744-50, 1996. PMID: 8670878.
- Harhaj EW, Maggirwar SB, Sun SC. Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells. Oncogene 12(11):2385-92, 1996. PMID: 8649779.
- Good LF, Maggirwar SB, Kealiher A, Uhlik M, Sun SC. Multiple structural domains within I kappa B alpha are required for its inducible degradation by both cytokines and phosphatase inhibitors. Biochem Biophys Res Commun 223(1):123-8, 1996. PMID: 8660357.
- Good L, Sun SC. Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta. J Virol 70(5):2730-5, 1996. PMID: 8627746.
- Sun S, Elwood J, Greene WC. Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation. Mol Cell Biol 16(3):1058-65, 1996. PMID: 8622650.
- Harhaj E, Blaney J, Millhouse S, Sun SC. Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR. Virology 216(1):284-7, 1996. PMID: 8615004.
- Maggirwar SB, Harhaj E, Sun SC. Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor. Oncogene 11(5):993-8, 1995. PMID: 7675460.
- Chen F, Kuhn DC, Sun SC, Gaydos LJ, Demers LM. Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages. Biochem Biophys Res Commun 214(3):839-46, 1995. PMID: 7575553.
- Chen F, Sun SC, Kuh DC, Gaydos LJ, Demers LM. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages. Biochem Biophys Res Commun 214(3):985-92, 1995. PMID: 7575573.
- Sun SC, Maggirwar SB, Harhaj E. Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J Biol Chem 270(31):18347-51, 1995. PMID: 7629157.
- Sun SC, Faye I. Transcription of immune genes in the giant silkmoth, Hyalophora cecropia, is augmented by H2O2 and diminished by thiol reagents. Eur J Biochem 231(1):93-8, 1995. PMID: 7628488.
- Lindström-Dinnetz I, Sun SC, Faye I. Structure and expression of hemolin, an insect member of the immunoglobulin gene superfamily. Eur J Biochem 230(3):920-5, 1995. PMID: 7601154.
- Sun SC, Elwood J, Béraud C, Greene WC. Human T-cell leukemia virus type I tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol 14(11):7377-84, 1994. PMID: 7935451.
- Sun SC, Ganchi PA, Béraud C, Ballard DW, Greene WC. Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci U S A 91(4):1346-50, 1994. PMID: 8108414.
- Béraud C, Sun SC, Ganchi P, Ballard DW, Greene WC. Human T-cell leukemia virus type I tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol Cell Biol 14(2):1374-82, 1994. PMID: 8289813.
- Ganchi PA, Sun SC, Greene WC, Ballard DW. A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol 13(12):7826-35, 1993. PMID: 8246997.
- Engström Y, Kadalayil L, Sun SC, Samakovlis C, Hultmark D, Faye I. Kappa B-like motifs regulate the induction of immune genes in drosophila. J Mol Biol 232(2):327-33, 1993. PMID: 8345514.
- Schmidt O, Faye I, Lindström-Dinnetz I, Sun SC. Specific immune recognition of insect hemolin. Dev Comp Immunol 17(3):195-200, 1993. PMID: 8325433.
- Sun SC, Ganchi PA, Ballard DW, Greene WC. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259(5103):1912-5, 1993. PMID: 8096091.
- Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A 90(3):1023-7, 1993. PMID: 8430069.
- Ganchi PA, Sun SC, Greene WC, Ballard DW. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol Biol Cell 3(12):1339-52, 1992. PMID: 1493333.
- Sun SC, Faye I. Affinity purification and characterization of CIF, an insect immunoresponsive factor with NF-kappa B-like properties. Comp Biochem Physiol B 103(1):225-33, 1992. PMID: 1451434.
- Sun SC, Faye I. Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappa B. Eur J Biochem 204(2):885-92, 1992. PMID: 1541299.
- Sun SC, Asling B, Faye I. Organization and expression of the immunoresponsive lysozyme gene in the giant silk moth, hyalophora cecropia. J Biol Chem 266(10):6644-9, 1991. PMID: 2007608.
- Sun SC, Lindström I, Lee JY, Faye I. Structure and expression of the attacin genes in hyalophora cecropia. Eur J Biochem 196(1):247-54, 1991. PMID: 2001705.
- Sun SC, Lindström I, Boman HG, Faye I, Schmidt O. Hemolin: an insect-immune protein belonging to the immunoglobulin superfamily. Science 250(4988):1729-32, 1990. PMID: 2270488.
- Andersson K, Sun S-C, Boman HG, Steiner H. Purification of the prophenoloxidase from hyalophora cecropia and four proteins involved in its activation. Insect Biochem 19(7):629-37, 1989.
- Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nat Immunol. e-Pub 2021. PMID: 33398181.
- Xie X, Zhu L, Jie Z, Li Y, Gu M, Zhou X, Wang H, Chang JH, Ko CJ, Cheng X, Sun SC. TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. Cell Mol Immunol. e-Pub 2020. PMID: 33203937.
- Ko CJ, Zhang L, Jie Z, Zhu L, Zhou X, Xie X, Gao T, Yang JY, Cheng X, Sun SC. The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses. EMBO J:e104532. e-Pub 2020. PMID: 33215753.
- Yang JY, Jie Z, Mathews A, Zhou X, Li Y, Gu M, Xie X, Ko CJ, Cheng X, Qi Y, Estrella JS, Wang J, Sun SC. Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice. Gastroenterology. e-Pub 2020. PMID: 32745468.
Invited Articles
- Sun SC. A20 restricts inflammation via ubiquitin binding. Nat Immunol 21(4):362-364, 2020. PMID: 32205879.
- Shi JH, Xie X, Sun SC. TBK1 as a regulator of autoimmunity and antitumor immunity. Cell Mol Immunol 15(8):743-745, 2018. e-Pub 2018. PMID: 29503440.
- Shi JH, Sun SC. Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways. Front Immunol 9:1849, 2018. e-Pub 2018. PMID: 30140268.
- Sun SC. The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol 17(9):545-558, 2017. e-Pub 2017. PMID: 28580957.
- Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther 2, 2017. e-Pub 2017. PMID: 29158945.
- Hu H, Sun SC. Ubiquitin signaling in immune responses. Cell Res 26(4):457-83, 2016. e-Pub 2016. PMID: 27012466.
- Shi JH, Sun SC. TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex. Mol Immunol 68(2 Pt C):546-57, 2015. e-Pub 2015. PMID: 26260210.
- Xiao Y, Sun SC. TPL2 mediates IL-17R signaling in neuroinflammation. Oncotarget 6(26):21789-90, 2015. PMID: 26318043.
- Yang XD, Sun SC. Targeting signaling factors for degradation, an emerging mechanism for TRAF functions. Immunol Rev 266(1):56-71, 2015. PMID: 26085207.
- Zhang H, Sun SC. NF-κB in inflammation and renal diseases. Cell Biosci 5:63, 2015. e-Pub 2015. PMID: 26579219.
- Cheng H, Ren T, Sun SC. New insight into the oncogenic mechanism of the retroviral oncoprotein Tax. Protein Cell 3(8):581-9, 2012. e-Pub 2012. PMID: 22865346.
- Sun SC. Immune receptor signaling: from ubiquitination to NF-κB activation. Cell Mol Immunol 9(2):97-8, 2012. e-Pub 2012. PMID: 22231553.
- Jin W, Chang M, Sun SC. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol 9(2):113-22, 2012. e-Pub 2012. PMID: 22307041.
- Sun SC. The noncanonical NF-κB pathway. Immunol Rev 246(1):125-40, 2012. PMID: 22435551.
- Sun SC, Cesarman E. NF-kappaB as a Target for Oncogenic Viruses. Curr Top Microbiol Immunol 349:197-244, 2011. e-Pub 2010. PMID: 20845110.
- Sun SC. Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling. Sci Signal 3(123):pe18, 2010. e-Pub 2010. PMID: 20501935.
- Sun SC. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ 17(1):25-34, 2010. e-Pub 2009. PMID: 19373246.
- Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol 29(10):469-78, 2008. e-Pub 2008. PMID: 18775672.
- Sun SC. Deubiquitylation and regulation of the immune response. Nat Rev Immunol 8(7):501-11, 2008. PMID: 18535581.
- Sun SC, Yamaoka S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 24(39):5952-64, 2005. PMID: 16155602.
- Sun SC, Xiao G. Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev 22(4):405-22, 2003. PMID: 12884915.
- Sun SC, Harhaj EW, Xiao G, Good L. Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma. AIDS Res Hum Retroviruses 16(16):591-6, 2000. PMID: 11080796.
- Sun SC, Ballard DW. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases. Oncogene 18(49):6948-58, 1999. PMID: 10602469.
- Yang XD, Sun SC. Deubiquitinases as pivotal regulators of T cell functions. Front Med 12(4):451-462. e-Pub 2018. PMID: 30054854.
Book Chapters
- Sun S-C, Harhaj EW. Receptors and adaptors for NF-kB signaling. In: NF-kB/Rel Transcription Factor Family. Springer Science: New York, 2006.
Grant & Contract Support
| Title: | Signaling functions of Peli family of E3 ubiquitin ligases |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | Regulation of T-cell function and autoimmune inflammation by deubiquitinases |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | Molecular mechanisms regulating TLR signaling and macrophage activation |
| Funding Source: | NIH/NIAID (Competitive Renewal, Reviewed in October 2019 Study Section (Impact Score: 20; Percentile: 4.0) |
| Role: | Principal Investigator |
| Title: | Role of TBK1 in regulating dendritic cell function and antitumor immunity |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Regulation of MDM2-mediated oncogenesis and anti-tumor immunity by USP15 |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Molecular studies of noncanonical NF-kb signaling |
| Funding Source: | NIH/NIGMS |
| Role: | Principal Investigator |
| Title: | Defining protective responses in hematopoietic cells mediated by STAT3 anti-inflammatory activity |
| Funding Source: | NIH/NIAID |
| Role: | Co-Investigator |
| Title: | Combating breast cancer brain metastasis by blocking the two-pronged driver kinase function of CDK5 |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Role of Cul4A in governing Th2-type tolerance |
| Funding Source: | NIH/NHLBI |
| Role: | Other Significant Contributor |
| Title: | Molecular mechanisms regulating TLR signaling and inflammation |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | Regulation of CD8 T cell responses in antitumor immunity |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | CPF1-guided in vivo genome-wide screen for discovery of immunotherapy in pancreatic cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Investigator |
| Title: | Role of E3 ubiquitin ligase RNF133 in T cell function and tolerance |
| Funding Source: | NIH/NHLBI |
| Role: | Other Significant Contributor |
| Title: | The EZH2 deubiquitinase ZRANB1 as a therapeutic target in breast cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Other Significant Contributor |