Shumei Song
Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1999 | Beijing Institute for Cancer Research, The School of Oncology, Beijing University, Beijing, CHN, PHD, Biochemistry and Molecular Biology |
| 1989 | Wuhan University, Hubei Medical College, Hubei, CHN, MS, Microbiology & Immunolgy |
| 1986 | Binjou Medical College, Shandong, CHN, MD |
Postgraduate Training
| 2002-2004 | Postdoctoral Fellow, Department of GI Medicine and Nutrition The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1999-2002 | Postdoctoral Fellow, Department of Clinical Cancer Prevention, U.T.M.D. Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Assistant Professor, Department of Gastroenterology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2011
Instructor, Department of Department of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2004 - 2008
Selected Publications
Peer-Reviewed Articles
- Harada K, Pool Pizzi M, Baba H, Shanbhag ND, Song S, Ajani JA. Cancer stem cells in esophageal cancer and response to therapy. Cancer 124(20):3962-3964, 2018. e-Pub 2018. PMID: 30368777.
- Song S, Ajani JA. Reply. Gastroenterology 155(3):934-935, 2018. e-Pub 2018. PMID: 30098926.
- Vicente D, Ikoma N, Chiang YJ, Fournier K, Tzeng CD, Song S, Mansfield P, Ajani J, Badgwell BD. Preoperative Therapy for Gastric Adenocarcinoma is Protective for Poor Oncologic Outcomes in Patients with Complications After Gastrectomy. Ann Surg Oncol 25(9):2720-2730, 2018. e-Pub 2018. PMID: 29987602.
- Harada K, Song S, Ajani JA. Attenuation of YAP1 can potentially target cancer stem cells to overcome drug resistance. Oncoscience 5(7-8):214-215, 2018. e-Pub 2018. PMID: 30234141.
- Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med 24(5):556-562, 2018. e-Pub 2018. PMID: 29736026.
- Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun 9(1):1777, 2018. e-Pub 2018. PMID: 29725014.
- Zhao W, Ajani JA, Sushovan G, Ochi N, Hwang R, Hafley M, Johnson RL, Bresalier RS, Logsdon CD, Zhang Z, Song S. Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling. Gastroenterology 154(5):1524-1537.e6, 2018. e-Pub 2017. PMID: 29274868.
- Song S, Xie M, Scott AW, Jin J, Ma L, Dong X, Skinner HD, Johnson RL, Ding S, Ajani JA. A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther 17(2):443-454, 2018. e-Pub 2017. PMID: 29167315.
- Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S. Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors. Br J Cancer 118(1):52-61, 2018. e-Pub 2017. PMID: 29136404.
- Lopez A, Harada K, Mizrak Kaya D, Dong X, Song S, Ajani JA. Liquid biopsies in gastrointestinal malignancies: when is the big day?. Expert Rev Anticancer Ther 18(1):19-38, 2018. e-Pub 2017. PMID: 29202614.
- Harada K, Dong X, Estrella JS, Correa AM, Xu Y, Hofstetter WL, Sudo K, Onodera H, Suzuki K, Suzuki A, Johnson RL, Wang Z, Song S, Ajani JA. Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma. Gastric Cancer 21(1):31-40, 2018. e-Pub 2017. PMID: 28801853.
- Wadhwa R, Wang X, Baladandayuthapani V, Liu B, Shiozaki H, Shimodaira Y, Lin Q, Elimova E, Hofstetter WL, Swisher SG, Rice DC, Maru DM, Kalhor N, Bhutani MS, Weston B, Lee JH, Skinner HD, Scott AW, Kaya DM, Harada K, Berry D, Song S, Ajani JA. Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients. Br J Cancer 117(5):648-655, 2017. e-Pub 2017. PMID: 28728163.
- Mizrak Kaya D, Dong X, Nogueras-González GM, Xu Y, Estrella JS, Harada K, Lopez A, Amlashi FG, Hofstetter WL, Maru DM, Nguyen QN, Lee JH, Weston B, Bhutani MS, Erasmus JJ, Thomas I, Rogers JE, Song S, Ajani JA. Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients. Med Oncol 34(8):135, 2017. e-Pub 2017. PMID: 28685276.
- Elimova E, Lin Q, Song S, Ajani JA. Current status of ramucirumab in gastroesophageal adenocarcinoma. Future Oncol 13(18):1585-1592, 2017. e-Pub 2017. PMID: 28436242.
- Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. Gastric adenocarcinoma. Nat Rev Dis Primers 3:17036, 2017. e-Pub 2017. PMID: 28569272.
- Harada K, Mizrak Kaya D, Shimodaira Y, Song S, Baba H, Ajani JA. Translating genomic profiling to gastrointestinal cancer treatment. Future Oncol 13(10):919-934, 2017. e-Pub 2017. PMID: 28067073.
- Yin Y, Shen Q, Zhang P, Tao R, Chang W, Li R, Xie G, Liu W, Zhang L, Kapoor P, Song S, Ajani J, Mills GB, Chen J, Tao K, Peng G. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res 7(3):473-483, 2017. e-Pub 2017. PMID: 28401005.
- Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64(5):1757-1772, 2016. e-Pub 2016. PMID: 27531557.
- Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. EBioMedicine 13:113-124, 2016. e-Pub 2016. PMID: 27789274.
- Elimova E, Song S, Shimodaira Y, Lin Q, Ajani JA. Exploiting Molecular and Immune Biology of Gastric and Gastroesophageal Adenocarcinomas to Discover Novel Therapeutic Targets. Ann Surg Oncol 23(12):3786-3791, 2016. e-Pub 2016. PMID: 27503493.
- Zhou M, Song S, Zhao J, Tian M, Li C. Theranostic CuS Nanoparticles Targeting Folate Receptors for PET Image-Guided Photothermal Therapy. J Mater Chem B Mater Biol Med 3(46):8939-8948, 2015. e-Pub 2015. PMID: 27725882.
- Chen Q, Song S, Wei S, Liu B, Honjo S, Scott A, Jin J, Ma L, Zhu H, Skinner HD, Johnson RL, Ajani JA. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget 6(28):25883-96, 2015. PMID: 26317542.
- Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res 21(11):2580-90, 2015. e-Pub 2015. PMID: 25739674.
- Ajani JA, Song S, Hochster HS, Steinberg IB. Introduction. Semin Oncol 42 Suppl 1:S1-2, 2015. e-Pub 2015. PMID: 25839663.
- Ajani JA, Song S, Hochster HS, Steinberg IB. Cancer stem cells: the promise and the potential. Semin Oncol 42 Suppl 1:S3-17, 2015. e-Pub 2015. PMID: 25839664.
- Elimova E, Wadhwa R, Shiozaki H, Sudo K, Estrella JS, Badgwell BD, Das P, Matamoros A, Song S, Ajani JA. Molecular biomarkers in gastric cancer. J Natl Compr Canc Netw 13(4):e19-29, 2015. PMID: 26052595.
- Shimodaira Y, Elimova E, Wadhwa R, Shiozaki H, Charalampakis N, Planjery V, Rogers JE, Song S, Ajani JA. Ramucirumab for the treatment of gastroesophageal cancers. Expert Opin Orphan Drugs 3(6):737-746, 2015. e-Pub 2015. PMID: 27570714.
- Skinner HD, Lee JH, Bhutani MS, Weston B, Hofstetter W, Komaki R, Shiozaki H, Wadhwa R, Sudo K, Elimova E, Song S, Ye Y, Huang M, Ajani J, Wu X. A validated miRNA profile predicts response to therapy in esophageal adenocarcinoma. Cancer 120(23):3635-41, 2014. e-Pub 2014. PMID: 25091571.
- Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA. Medical management of gastric cancer: A 2014 update. World J Gastroenterol 20(38):13637-13647, 2014. PMID: 25320502.
- Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella J, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. Carcinogenesis 35(9):2031-8, 2014. e-Pub 2014. PMID: 24990617.
- Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol 45(2):567-74, 2014. e-Pub 2014. PMID: 24859412.
- Elimova E, Song S, Ajani JA. EGFR as a Therapeutic Target for Gastroesophageal Cancer—or Is It Really?. ASCO Post 5(13), 2014.
- Wadhwa R, Elimova E, Shiozaki H, Sudo K, Blum MA, Estrella JS, Chen Q, Song S, Ajani JA. Anti-angiogenic agent ramucirumab: meaningful or marginal?. Expert Rev Anticancer Ther 14(4):367-79, 2014. e-Pub 2014. PMID: 24605771.
- Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol 8(1):142-9, 2014. e-Pub 2013. PMID: 24210755.
- Wadhwa R, Song S, Lee JS, Yao Y, Wei Q, Ajani JA. Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol 10(11):643-55, 2013. e-Pub 2013. PMID: 24061039.
- Song S, Maru DM, Ajani JA, Chan CH, Honjo S, Lin HK, Correa A, Hofstetter WL, Davila M, Stroehlein J, Mishra L. Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma. Cancer Res 73(7):2159-69, 2013. e-Pub 2013. PMID: 23536563.
- Song S, Ajani JA. The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol 10(2):109-18, 2013. e-Pub 2012. PMID: 23165235.
- Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling. PLoS One 7(8):e42699, 2012. e-Pub 2012. PMID: 22900040.
- Mendelson J, Song S, Li Y, Maru DM, Mishra B, Davila M, Hofstetter WL, Mishra L. Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer 117(16):3691-702, 2011. e-Pub 2011. PMID: 21305538.
- Song S, Byrd JC, Guha S, Liu KF, Koul D, Bresalier RS. Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway. Cancer 117(11):2386-97, 2011. e-Pub 2010. PMID: 24048786.
- Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prev Res (Phila Pa) 2(3):274-80, 2009. e-Pub 2009. PMID: 19258542.
- Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3 beta activity. Cancer Res 69(4):1343-9, 2009. e-Pub 2009. PMID: 19190323.
- Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res 15(2):622-31, 2009. PMID: 19147768.
- Song S, Guha S, Liu KF, Buttar NS, Bresalier RS.. Induction of COX-2 by unconjugated bile acids involves reactive oxygen species-mediated signaling pathway in the esophagus. Gut 56:1512-1521, 2007.
- Song S, Lippman SM, Zou Y, Ye X, Ajani JA, Xu XC. Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. Oncogene 24(56):8268-76, 2005. PMID: 16170369.
- Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS. Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. Gastroenterology 129(5):1581-91, 2005. PMID: 16285957.
- Song S, Byrd JC, Koo JS, Bresalier RS. Bile acids induce MUC2 overexpression in human colon carcinoma cells. Cancer 103(8):1606-14, 2005. PMID: 15754327.
- Jiang B, Liu W, Qu H, Meng L, Song S, Quyang T,Shou C.. A novel peptide isolated from a phage display peptide library with Trastuzumab can mimic antigen epitope of HER2. The Journal of Biological Chemistry 280 (6):4656-4662, 2005.
- An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer 111(2):165-73, 2004. PMID: 15197767.
- Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM. Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. Neoplasia 5(2):121-7, 2003. PMID: 12659684.
- Lei H, An P, Song S, Liu X, He L, Wu J, Meng L, Liu M, Yang J, Shou C. A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth factor to its Kinase Domain Receptor. J. Bio Chem 277:43137-43142, 2002.
- Li M, Song S, Lippman SM, Zhang XK, Liu X, Lotan R, Xu XC. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene 21(3):411-8, 2002. PMID: 11821953.
- Tian X, Song S, Wu J, Meng L, Dong Z, Shou C. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 286(3):505-12, 2001. PMID: 11511087.
- Song S, Xu XC. Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells. Biochem Biophys Res Commun 281(4):872-7, 2001. PMID: 11237740.
- Song S, Wu J, Shou C. Inhibition of Monoclonal Antibodies against Extracellular I-IV domains of Vascular Endothelial Cell Growth Factor Receptor KDR on the Proliferation EC and Formation of Chicken embryo blood Vessels. Chin J Microbiol Immunol 20(4):327-330, 2000.
- Song S, Shou C. Inhibition of prokaryotic expressed soluble KDR receptor on activity of Vascular Endothelial Growth Factor. Natl Med J China 80:226-227, 2000.
- Song S, Zeng L, et al. Cloning and McAb Preparation of VEGF Receptor KDR Extracellular V-VII domains and its expression in Different Originated Tumors. Chinese Journal of Oncology 21:96-98, 1999.
- Song S, Shou C. Cloning and Expression of Truncated KDR Binding to Vascular Endothelial Growth. Prog. Biochem. Biophys 26:481-484, 1999.
- Song S, Wu J, Shou C. The Preparation and Identification of Monoclonal Antibodies against Vascular endothelial Cell Growth Factor Receptor (KDR) . Journal of Beijing Medical University 30:509-511, 1998.
- Song S, Wu J, Shou C. Expression of VEGF Receptor II, KDR, in Different Originated Carcinoma. Chinese Journal of Cancer Research 10(3):104-108, 1998.
- Song S, Shou C. Molecular cloning and prokaryotic expression of Vascular Endothelial Growth Factor Receptor KDR. Journal of Chinese Biochemistry and Molecular Biology 14:57-6, 1998.
- Song S, Shou C. Telomerase---the new target for cancer therapy. Foreign Medical Oncology Fascicle 17:86-89, 1997.
- Song S, Shou C. Molecular-biology research progression of VEGF and VEGF receptor. Foreign Medical Molecular Biology Fascicle 19:245-250, 1997.
- Song S et al. Examination of HSV-2 antigen in autoplastic cervical cancer and proliferated tissue in mice. Cancer Research of Prevention and Treatment 22(3):144-145, 1995.
- Li J, Song S. LAK cells from abdominal ascites treating a case of hepatic cancer. Cancer Research of Prevention and Treatment 21:98-99, 1994.
- Zhang Y, Song S, et al. Development of desmin and its role for tumor distinguished diagnosis. Cancer Research of Prevention and Treatment 19(2):24-28, 1992.
- Song S, Chen M. Cancer of autoplastic cervix and vagina induced with Herpes Simplex Virus type2 in mice. Journal China Experimental and clinical Virology 6:227-232, 1992.
- Song S*, Xu Y, Jin JK, Ma L, Scott A, Zhao W, Dong XC, Pizzi MP, Liu B, Johnson L R and Ajani JA. Targeting Hippo Coactivator YAP1 through BET bromodomain inhibition in Esophageal Adenocarcinoma.
- Harada K, Mizrak Kaya D, Shimodaira Y, Song S, Baba H, Ajani JA. Proteomics approach to identify biomarkers for upper gastrointestinal cancer. Expert Rev Proteomics. e-Pub 2016. PMID: 27718753.
- Song S*, Estrella JS, Xie M, Chen Q, Jin JK, Ma L, Scott AW, Liu B, Ding S, Hung MC, Johnson RL and Ajani JA. PPAR mediates its oncogenic function in gastric cancer through interaction and activation of Hippo coactivator YAP1. Gastroenterology.
- Li F, Xu Y, Liu B, Jin JK, Zhao W, Scott A, Dong XC, Ma L, Pizzi MP, Wang Y, Harada K, Xie M, Skinner HD, Ding S, Johnson LR, Song S* and Ajani JA*. YAP1 mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer-Rationale for the combination of YAP1 and CDK4/6 inhibitors in EC. JNCI.
- Li F, Xu Y, Liu B, Singh PK, Zhao W, Jin J, Han G, Scott AW, Dong X, Huo L, Ma L, Pool Pizzi M, Wang Y, Li Y, Harada K, Xie M, Skinner HD, Ding S, Wang L, Krishnan S, Johnson RL, Song S, Ajani JA. YAP1-mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the combination of YAP1 and CDK4/6 inhibitors in Esophageal Cancer. Clin Cancer Res. e-Pub 2018. PMID: 30563933.
- Song S, Mishra L. Reply to dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. Cancer. e-Pub 2011. PMID: 21898378.
Grant & Contract Support
| Title: | The role of bile acids and Benzo(a)pyrene diol epoxide in the development of esophageal adenocarcinoma |
| Funding Source: | AGA Foundation for Digestive Health and Nutrition |
| Role: | Principal Investigator |
| Title: | Inhibition of Hedgehog Signaling in Gli-1 + Adeno CA |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Prediction of Pathologic Complete Response by Gene Expression in Esophageal Adenocarcinoma,CA |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Targeting Hippo YAP1/SOX9 axis as Novel Therapeutic Strategy in Esphageal Adenocarcinoma |
| Funding Source: | UTMDACC IRG Program |
| Role: | Principal Investigator |
| Title: | Characterize and Target Hippo/YAP1 in Peritoneal Metastasis of Gastric Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Characterize and Target Hippo/YAP1 in Peritoneal Metastasis of Gastric Adenocarcinoma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Hippo/YAP1 mediates tumor immune suppression by activation of novel immune checkpoint TIM3/Galectin-9 in Advanced Gastric Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Role of Hippo/YAP1 in Peritoneal Metastasis of Gastric Cancer-Implications for Novel Target Therapeutic Strategies |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Discover Novel Biomarkers/Targets for Advanced Gastric Adenocarcinoma Patients by Exploring Tumor-Associated Exosomes from Malignant Ascites |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Immune-Suppression and Tumor-Stromal Interaction Mediated by Galectin-3 in Gastric Cancer-Implications of Therapeutic Strategies |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Exploiting RhoA Mutations in Diffuse Gastric Adenocarcinoma and Targeting Intertwined RhoA and Yap1 Pathways for Therapeutic Advantage |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Investigator |
| Title: | Discover Novel Therapeutic Strategies for Peritoneal Metastases from Gastric Adenocarcinoma |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Investigator |
| Title: | Novel Immune Suppression and Metastatic Niche Mediated by Hippo/YAP1 in Advanced Gastric Cancer-Implication of Novel Therapeutic Strategies |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Dysfunctional TGF-β Signaling with Constitutively Active Notch Signaling Contributes to Barrett's Esophageal Adenocarcinoma |
| Funding Source: | MDACC |
| Role: | Principal Investigator-MDACC |
| Title: | Dysfunctional of TGF-β signaling via β2SP activates SOX9 and C-MYC via Notch signaling in Hepatocellular |
| Funding Source: | MDACC |
| Role: | Principal Investigator-MDACC |
| Title: | The role of Galectin-3 in pancreatic stromal-epithelial interactions and associated tumor fibrosis |
| Funding Source: | Texas Medical Center Digestive Disease Center |
| Role: | Principal Investigator |
| Title: | Mucin glycoproteins in colorectal cancer metastasis |
| Funding Source: | NIH/NCI |
| Role: | Investigator |