Meet V. Craig Jordan, The Father of Tamoxifen
V. Craig Jordan, CMG, OBE, Ph.D., D.Sc., FMedSci
Department of Breast Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Professor of Breast Medical Oncology, Professor of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1973 | University of Leeds, Leeds, West Yorkshire, GBR, PHD, Pharmacology |
| 1969 | University of Leeds, Leeds, West Yorkshire, GBR, BS, Pharmacology |
Honors & Awards
| 2019 | Reynold Spector Award in Clinical Pharmacology, ASPET |
| 2018 | Giants of Cancer Care in Translational Scientific Advances, OncLive |
| 2018 | Gerald D Aurbach Award for Outstanding Translational Research, Endocrine Society |
| 2017 | Elected Member, National Academy of Medicine |
| 2016 | Big Four for the Millennium (zur Hausen, Senn, Veronesi, Jordan), German Society of Gynaecology & Obstetrics |
| 2015 | Sir James Black Award, British Pharmacological Society |
| 2014 | Selected as one of the 50 Oncology Luminaries, American Society of Clinical Oncology |
| 2011 | St. Gallen International Breast Cancer Award |
| 2010 | Elected President of the Royal Society of Medicine Foundation in North America |
| 2009 | The Jephcott Medal, Royal Society of Medicine |
| 2009 | Elected Fellow, Academy of Medical Sciences (UK equivalent of NAM) |
| 2009 | Elected Member, National Academy of Sciences |
| 2008 | Honorary Fellowship of the Royal Society of Medicine, Royal Society of Medicine |
| 2008 | Elected Honorary Member, Royal Pharmaceutical Society of Great Britain |
| 2006 | American Cancer Society Award for Chemoprevention, American Society of Clinical Oncology |
| 2003 | The Charles F. Kettering Prize, General Motors Cancer Research Foundation |
| 2003 | North American Menopause Society/Eli Lilly SERM Research Award, North American Menopause Society |
| 2003 | Third George and Christine Sosnovsky Award in Cancer Therapy, Royal Society of Chemistry |
| 2002 | Officer of the Most Excellent Order of the British Empire |
| 2002 | Inaugural Dorothy P. Landon AACR Prize in Translational Research |
| 2001 | Bristol Myers Squibb Award, Bristol Myers Squibb |
| 2000 | Honorary Fellowship Award and medal, Faculty of Medicine of University College, Dublin, Ireland |
| 1996 | Herbert J. Block Memorial Award for Distinguished Achievement in Cancer, The Ohio State University |
| 1993 | Gaddum Memorial Award, British Pharmacological Society |
| 1993 | Cameron Prize for Therapeutics, Edinburgh University Medical School |
| 1989 | Eighth Bruce F. Cain Memorial Award, American Association for Cancer Research |
Selected Publications
Peer-Reviewed Articles
- Fan P, Maximov PY, Curpan RF, Abderrahman B, Jordan VC. The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy. Mol Cell Endocrinol. e-Pub 2015. PMID: 26052034.
- Murphy CS, Jordan VC. The biological significance of the interaction of estrogen agonists and antagonists with the estrogen receptor. Receptor 1(1-2):65-82, 1990. PMID: 2152373.
- Ravdin PM, Fritz NF, Tormey DC, Jordan VC. Endocrine status of premenopausal node-positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen. Cancer Res 48(4):1026-9, 1988. PMID: 3123050.
- Jordan VC, Robinson SP. Species-specific pharmacology of antiestrogens: role of metabolism. Fed Proc 46(5):1870-4, 1987. PMID: 3556610.
- Tormey DC, Jordan VC. Long-term tamoxifen adjuvant therapy in node-positive breast cancer: a metabolic and pilot clinical study. Breast Cancer Res Treat 4(4):297-302, 1984. PMID: 6394068.
- Jordan VC, Allen KE. Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. Eur J Cancer 16(2):239-51, 1980. PMID: 6768559.
- Jordan VC. Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse. J Reprod Fertil 42(2):251-8, 1975. PMID: 163905.
- Jordan VC, Koerner S. Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes. J Endocrinol 64(1):193-4, 1975. PMID: 163879.
- Clark ER, Evans JG, Jordan VC. Anti-oestrogenic activity in compounds related to ethamoxytriphetol (MER 25), clomiphene and MRL 37. Br J Pharmacol 48(2):345P, 1973. PMID: 4733745.
Invited Articles
- Jordan VC, Curpan R, Maximov PY. Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators. J Natl Cancer Inst 107(6), 2015. e-Pub 2015. PMID: 25838462.
- Jordan VC. The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer. Endocr Relat Cancer 22(1):R1-31, 2015. e-Pub 2015. PMID: 25339261.
- Fan P, Cunliffe HE, Maxmov PY, Agboke, FA, McDaniel RE, Zou X, Ramos P, Russel ML, Jordan VC. Integration of downstream signals of insulin-like growth factor-1 receptor by endoplamic reticulum stress for estrogen-induced growth or apoptosis in breast cancer cells. Mol Cancer Res 13(10):1367-76, 2015. e-Pub 2015. PMID: 26116171.
- Fan P, Maximov PY, Curpan RF, Abderrahman B, Jordan VC. The molecular, cellular and clinical consequences of targeting the estrgen receptor following estrogen deprivation therapy. Mol Cell Endocrinol 418(3):245-63, 2015. e-Pub 2015. PMID: 26052034.
Letters to the Editor
- Jordan VC, Maximov PY, Fan P. Progesterone and synthetic progestin controversies. JAMA Oncol 1: 986-7, 2015.