Xiao Wu, PhD
Department of Genetics, Division of Basic Sciences
About Xiao Wu
Dr. Wu is an instructor in the department of Genetics. Originated from China, she received her master degree and PhD degree in Genetics from College of Life Science, Nankai University. She worked on screening of biomarkers in breast cancer patients and discovered the chromodomain helicase DNA binding protein 5 (CHD5) plays an important tumor suppressor role in breast cancer. She completed her postdoctoral training at MD Anderson Cancer Center in the Department of Genetics, focusing on study of DNA damage repair pathways in response to DNA double-strand breaks and replication stress by using cultured human cells and mouse models. She discovered Abro1 safeguards genome stability and inhibits tumorigenesis by inhibition of deleterious over-resection at stalled replication forks. She also discovered Cezanne and Cezanne 2, two deubiquitinating enzymes were recruited to DNA double-strand break sites by binding to lysine 63-linked polyubiquitination chain and hydrolyzed lysine 11-linked polyubiquitination chain to insure proper downstream DNA repair protein complex assembly. This work demonstrated a key example of a crosstalk talk between linkage specific ubiquitination at DNA damage sites. Currently, she focus on investigation of a new BRCA1 regulator, and investigation the repair mechanisms of one-ended DNA double-strand breaks caused by chemotherapy drugs. Her overall goal is understanding how comprised DNA repair pathways lead to tumorigenesis and exploring new therapeutic strategy for cancer treatment.
Education & Training
Degree-Granting Education
| 2012 | College of Life Science, Nankai Universtiy, Tianjing, CHN, PHD, Genetics |
Postgraduate Training
| 2014-2019 | Research Fellowship, MD Anderson Cancer Center, Houston, TX |
Selected Publications
Peer-Reviewed Articles
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev 33(23-24):1702-1717, 2019. e-Pub 2019. PMID: 31699778.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A 115(10):E2311-E2319, 2018. e-Pub 2018. PMID: 29463696.
- Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev 31(14):1469-1482, 2017. PMID: 28860160.
- Wang XX, Liu BB, Wu X, Su D, Zhu Z, Fu L. Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma. Pathol Oncol Res 21(4):1021-6, 2015. e-Pub 2015. PMID: 25813822.
- Zhang Z, Zhu Z, Zhang B, Li W, Li X, Wu X, Wang L, Fu L, Fu L, Dong JT. Frequent mutation of rs13281615 and its association with PVT1 expression and cell proliferation in breast cancer. J Genet Genomics 41(4):187-95, 2014. e-Pub 2014. PMID: 24780616.
- Wu X, Zhu Z, Li W, Fu X, Su D, Fu L, Zhang Z, Luo A, Sun X, Fu L, Dong JT. Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer. Breast Cancer Res 14(3):R73, 2012. e-Pub 2012. PMID: 22569290.
- Su D, Fu X, Fan S, Wu X, Wang XX, Fu L, Dong XY, Ni JJ, Fu L, Zhu Z, Dong JT. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am J Pathol 180(3):1189-201, 2012. PMID: 22341523.
- Wang XX, Zhu Z, Su D, Lei T, Wu X, Fan Y, Li X, Zhao J, Fu L, Dong JT, Fu L. Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma. Hum Pathol 42(10):1410-9, 2011. e-Pub 2011. PMID: 21419475.
- Wang XX, Fu L, Li X, Wu X, Zhu Z, Fu L, Dong JT. Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers. Pathol Oncol Res 17(2):429-33, 2011. e-Pub 2010. PMID: 21116761.