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Abdullah A. Osman, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 123
Houston, TX 77030
Room Number: T5.3912

Education & Training

Degree-Granting Education

2000 UT Health Science Center at San Antonio, San Antonio, TX, PHD, Biochemistry and Molecular Cell Biology
1992 King Saud University, Saudi, Saudi Arabia, BS, Biochemistry

Postgraduate Training

2000-2003 Postdoctoral, Molecular Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO


Academic Appointments

Assistant Professor, Department of Molecular and Cellular Oncology, King Fahad Medical City, Faculty of Medicine, Riyadh, Saudi Arabia, 2007-2009
Research Instructor, Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, 2004-2007
Post-doctoral Fellow, Cell Biology, Washington University School of Medicine, St. Louis, MO, 2000-2003
Teaching Assistant, Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, San Antonio, TX, 1996-1997
Teaching Research Assistant, Department of Biochemistry and Molecular Biology, Northern Arizona University, Flagstaff, AZ, 1994-1995

Selected Publications

Peer-Reviewed Original Research Articles

1. Osman AA, Neskey DM, Katsonis P, Patel AA, Ward AM, Hsu TK, Hicks SC, McDonald TO, Ow TJ, Ortega AM, Pickering CR, Skinner HD, Zhao M, Sturgis EM, Kies MS, El-Naggar A, Perrone F, Licitra L, Bossi P, Kimmel M, Frederick MF, Lichtarge O, Myers JN. Evolutionary action score of TP53 coding variants (EAp53) is predictive of platinum response in head and neck cancer patients. Cancer Res 75(7):1205-15, Apr 2015, 4/2015. PMID: 25691460.
2. Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary action score of TP53 (EAp53) identifies high risk mutations associated with decreased survival and increased distant metastases in head and neck cancer. Cancer Res 75(7):1527-36, 1/2015. PMCID: PMCPCM4383697.
3. Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescense. Mol Cancer Ther 14(2):608-19, 1/2015. PMID: 25504633.
4. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser S, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol cell 54(6):960-74, June, 6/2014. e-Pub 5/2014. PMCID: PMCPMC4067806.
5. Osman AA, Schrader AD, Hawkes AJ, Akil O, Bergeron A, Lustig LR, Simmons DD. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci 38(2):153-69, 6/2008. e-Pub 3/2008. PMCID: PMC2480618.
6. Bergeron AL, Schrader A, Yang D, Osman AA, Simmons DD. The final stage of cholinergic differentiation occurs below inner hair cells during development of the rodent cochlea. J Assoc Res Otolaryngol 6(4):401-15, 12/2005. PMCID: PMC2504619.
7. Bao J, Lin H, Ouyang Y, Lei D, Osman AA, Kim TW, Mei L, Dai P, Ohlemiller KK, Ambronkkk RT. Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat Neurosci 7(11):1250-8, 11/2004. e-Pub 10/2004. PMID: 15494726.
8. Osman AA, Saito M, Makepeace C, Permutt MA, Schlesinger P, Mueckler M. Wolframin expression induces novel channel activity in endoplasmic reticulum membranes and increases intracellular calcium. J Biol Chem 278(52):52755-62, 12/2003. e-Pub 10/2003. PMCID: PMC495029.
9. Osman AA, Hancock J, Hunt DG, Ivy JL, Mandarino LJ. Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats. J Appl Physiol 90(2):454-60, 2/2001. PMID: 11160042.
10. Osman AA, Cusi K, Maezono K, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase pathways of insulin receptor signaling in human muscle. J Clin Invest 105(3):311-20, 2/2001. PMCID: PMC377440.
11. Osman AA, Pendergrass M, Koval J, Maezono K, Mandarino LJ,. Regulation of MAP kinase pathway activity in vivo in human skeletal muscle. Am J Physiol Endocrinol Metab 278(6):E992-9, June 2000, 6/2000. PMID: 10827000.
12. Fitzgerald AL,Osman AA, Xie TX, Patel A, Skinner H, Sandulache V, Myers JN. Reactive oxygen species and p21Waf1/Cip1 are both essential for p52-mediated senescence of head and neck cancer cells. Cell Death Dis, March 2015. Submitted. PMCID: PMCPMC4385922.

Grant & Contract Support

Title: Sensitization of HPV+HNSCC to cytotoxic treatments G2/M checkpoint with AZ-1775 to improve survival
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Principal Investigator
Principal Investigator: Myers
Duration: 3/1/2015 - 2/28/2018
Title: TP53 as a Biomarker to Personalize Chemotherapy for Patients with Head and Neck Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Myers
Duration: 12/1/2011 - 5/30/2014
Title: Towards personalized cancer therapy: stratification of oral and pharyngeal cancer based on p53 mutational status
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Myers
Duration: 8/1/2010 - 5/31/2015
Title: Development of Cholinergic Synapses in the Inner ear.
Funding Source: NIH/NIDCR
Role: Co-Investigator
Principal Investigator: Simmons
Duration: 4/1/2004 - 3/28/2007

Last updated: 8/24/2015