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Apar Pataer, MD, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Thoracic and Cardiovascular Surgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1996 Kyoto University, Kyoto, Japan, PHD, Cell Biology; Cancer Biology & Pathology
1988 Xinjiang Medical College, Urumqi, Xinjiang, China, MD, Medical

Postgraduate Training

10/1998-8/2001 Post-Doctoral Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX, Stephen Swisher, M.D.

Honors and Awards

1998 Young Investigator Award, Kyoto University
1994 Best Graduate Student Award, Society of Japanese Science
1990 Outstanding Employee, Xinjiang Academy of Medical Science
1989 Best Resident of the Year, Xinjiang People's Hospital

Professional Memberships

American Association of Cancer Research
Member, 1998-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Zhou Y, Hofstetter WL, He Y, Hu W, Pataer A, Wang L, Wang J, Zhou Y, Yu L, Fang B, Swisher SG. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol Ther 9(7):507-13, 11/2010. e-Pub 4/2010. PMCID: PMC2902679.
2. Pataer A, Raso MG, Correa AM, Behrens C, Tsuta K, Solis L, Fang B, Roth JA, Wistuba II, Swisher SG. Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients. Clin Cancer Res 16(22):5522-8, 11/2010. e-Pub 10/2010. PMCID: PMC3070287.
3. Fuson KL, Zheng M, Craxton M, Pataer A, Ramesh R, Chada S, Sutton RB. Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity. J Biol Chem 284(44):30526-33, 10/2009. e-Pub 9/2009. PMCID: PMC2781607.
4. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res 15(18):5688-95, 9/2009. e-Pub 9/2009. PMCID: PMC2745510.
5. Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG. Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J Pharmacol Exp Ther 328(3):866-72, 3/2009. e-Pub 12/2008. PMCID: PMC2658620.
6. Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn PG. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther 8(3):245-52, 2/2009. e-Pub 2/2009. PMCID: PMC2854203.
7. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther 15(9):616-24, 9/2008. e-Pub 6/2008. PMCID: PMC2553758.
8. Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Mol Cancer Ther 7(8):2528-2535, 8/2008. PMCID: PMC2597048.
9. Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG. Development of Ad-mda7/IL-24-resistant lung cancer cell lines. Cancer Biol Ther 7(1):103-8, 1/2008. PMID: 18059175.
10. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 13(20):6032-9, 10/2007. PMID: 17947465.
11. Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB. Genetic deletion of PKR abrogates TNF-induced activation of Iκβα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 26(8):1201-1212, 2/2007. e-Pub 2006. PMID: 16924232.
12. Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG. Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. Cancer Gene Ther 14(1):12-18, 1/2007. PMID: 17024233.
13. Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res 60(4):788-792, 2000. PMID: 10706081.
14. Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg 121(1):61-67, 2000. PMID: 11135160.

Book Chapters
1. Chada S, Bocangel D, Pataer A, Sieger K, Mhashilkar AM, Inoue S, Miyahara R, Roth JA, Swisher S, Hunt KK, Ramesh R. MDA-7/IL-24 as a multi-modality therapy for cancer. In: Gene Therapy for Cancer. Chap. 23. Ed(s) KK Hunt, S Vorburger. Humana Press, 413-434, 2007.

Last updated: 3/6/2013