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Adel K. El-Naggar, M.D., Ph.D.

Present Title & Affiliation


Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.,
Unit Number: 085
Houston, TX 77030
Room Number: G1.3561A
Phone: (713) 792-3109
Fax: (713) 745-3356

Education & Training

Degree-Granting Education

1978 Department of Immunology, US Naval Research Unit-3 Ein-Shams School of Medicine, Cairo, Egypt, PHD, Mechanism of Cell-Mediated Immunity in Tuberculous Meningitis
1973 Ein-Shams School of Medicine, Cairo, Egypt, DMSc, Clinical Pathology
1970 Ein-Shams School of Medicine, Cairo, Egypt, MBChB, M.D.

Honors and Awards

2014 Endocrine-Related Cancer Award, Society for Endocrinology
2012-present Foreign Member of the The Royal Society of Arts and Sciences in Gothenburg, Kungl. Vetenskaps- och Vitterhets-Samhället i Göteborg
2010 The American Head and Neck Surgeons, Hayes-Martin Memorial Lectureship
2007 The American Head and Neck Surgeons, Presidential Citation
1998-present Kenneth D. Muller Endowed Professorship in Cancer Research
1997-1998 The B. Rothschild Senior Research Scholarship, Curie Institute
1994 The Mediterranean Society of Tumor Markers, Recognition Award
1978 Letter of Merits, US Naval Medical Research, Unit - 3 (NAMRU - 3)

Selected Publications

Peer-Reviewed Original Research Articles

1. Henderson YC, Ahn SH, Ryu J, Chen Y, Williams MD, El-Naggar AK, Gagea M, Schweppe R, Haugen B, Lai SY, Clayman GL. Development and Characterization of Six New Human Papillary Thyroid Carcinoma Cell Lines. J Clin Endocrinol Metab. e-Pub 11/26/2014. PMID: 25427145.
2. Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): Recognition and differentiation from conventional leukoplakia and mimics! Head Neck 36(11):1662-8, 11/2014. e-Pub 8/28/2014. PMID: 24115154.
3. Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK. Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications. Clin Cancer Res. e-Pub 10/14/2014. PMID: 25316813.
4. Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R, Cancer Genome Atlas Network, Cancer Genome Atlas Network. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A 111(43):15544-9, 10/28/2014. e-Pub 10/13/2014. PMCID: PMC4217452.
5. Fakhry C, Zhang Q, Nguyen-Tan PF, Rosenthal D, El-Naggar A, Garden AS, Soulieres D, Trotti A, Avizonis V, Ridge JA, Harris J, Le QT, Gillison M. Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. J Clin Oncol 32(30):3365-73, 10/20/2014. e-Pub 6/23/2014. PMCID: PMC4195851.
6. Garden AS, Gunn GB, Hessel A, Beadle BM, Ahmed S, El-Naggar AK, Fuller CD, Byers LA, Phan J, Frank SJ, Morrison WH, Kies MS, Rosenthal DI, Sturgis EM. Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer. Cancer 120(19):3082-8, 10/1/2014. e-Pub 6/4/2014. PMCID: PMC4172550.
7. Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ. Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma. Clin Cancer Res. e-Pub 10/10/2014. PMID: 25303977.
8. Li J, Perlaky L, Rao P, Weber RS, El-Naggar AK. Development and characterization of salivary adenoid cystic carcinoma cell line. Oral Oncol 50(10):991-9, 10/2014. e-Pub 7/30/2014. PMID: 25086988.
9. Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, Bonner JA, Harris J, El-Naggar AK, Gillison ML, Jordan RC, Konski AA, Thorstad WL, Trotti A, Beitler JJ, Garden AS, Spanos WJ, Yom SS, Axelrod RS. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32(27):2940-50, 9/20/2014. PMCID: PMC4162493.
10. Takahashi Y, Bell D, Agarwal G, Roberts D, Xie TX, El-Naggar A, Myers JN, Hanna EY. Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma. Head Neck 36(8):1094-102, 8/2014. e-Pub 10/26/2013. PMID: 23836481.
11. Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A 111(30):11145-50, 7/29/2014. e-Pub 7/14/2014. PMCID: PMC4121829.
12. Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, Ward A, Tsai CJ, Ortega Alves MV, Zhou JH, Drummond J, El-Naggar AK, Gibbs R, Weinstein JN, Wheeler DA, Wang J, Frederick MJ, Myers JN. Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res 20(14):3842-8, 7/15/2014. e-Pub 5/29/2014. PMCID: PMC4102633.
13. Li Q, Zhang Y, El-Naggar AK, Xiong S, Yang P, Jackson JG, Chau G, Lozano G. Therapeutic Efficacy of p53 Restoration in Mdm2-overexpressing Tumors. Mol Cancer Res 12(6):901-11, 6/2014. e-Pub 3/5/2014. PMCID: PMC4058386.
14. Bell D, Holsinger FC, Ordonez N, El-Naggar AK. Intestinal-type adenocarcinoma of the larynx: Report of a rare aggressive phenotype and discussion of histogenesis. Head Neck 36(5):E44-7, 5/2014. e-Pub 11/14/2013. PMID: 24038722.
15. Ow TJ, Hanna EY, Roberts DB, Levine NB, El-Naggar AK, Rosenthal DI, DeMonte F, Kupferman ME. Optimization of long-term outcomes for patients with esthesioneuroblastoma. Head Neck 36(4):524-30, 4/2014. e-Pub 6/18/2013. PMID: 23780581.
16. Jakob JA, Kies MS, Glisson BS, Kupferman ME, Liu DD, Lee JJ, El-Naggar AK, Gonzalez-Angulo AM, Blumenschein GR. A Phase II study of Gefitinib in Patients with Advanced Salivary Gland Cancers. Head Neck. e-Pub 3/2/2014. PMID: 24585506.
17. Bell D, Hanna EY, Miele L, Roberts D, Weber RS, El-Naggar AK. Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diagn Pathol 18(1):10-3, 2/2014. e-Pub 10/10/2013. PMID: 24238845.
18. Millare GG, Guha-Thakurta N, Sturgis EM, El-Naggar AK, Debnam JM. Imaging Findings of Head and Neck Dermatofibrosarcoma Protuberans. AJNR Am J Neuroradiol 35(2):373-8, 2/2014. e-Pub 8/1/2013. PMID: 23907249.
19. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. e-Pub 1/27/2014. PMID: 24469034.
20. Gelbard A, Hale KS, Takahashi Y, Davies M, Kupferman ME, El-Naggar AK, Myers JN, Hanna EY. Molecular profiling of sinonasal undifferentiated carcinoma. Head Neck 36(1):15-21, 1/2014. e-Pub 4/30/2013. PMCID: PMC3874284.
21. Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife 3, 2014. e-Pub 10/1/2014. PMID: 25271376.
22. Santarpia L, Calin GA, Adam L, Ye L, Fusco A, Giunti S, Thaller C, Paladini L, Zhang X, Jimenez C, Trimarchi F, El-Naggar AK, Gagel RF. A miRNA signature associated with human metastatic medullary thyroid carcinoma. Endocr Relat Cancer 20(6):809-23, 12/2013. e-Pub 10/14/2013. PMID: 24127332.
23. Milbury K, Rosenthal DI, El-Naggar A, Badr H. An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncol 49(11):1067-71, 11/2013. e-Pub 8/13/2013. PMCID: PMC3964874.
24. Cockerill CC, Daram S, El-Naggar AK, Hanna EY, Weber RS, Kupferman ME. Primary sarcomas of the salivary glands: case series and literature review. Head Neck 35(11):1551-7, 11/2013. e-Pub 6/1/2013. PMID: 23728801.
25. Neskey DM, Klein JD, Hicks S, Garden AS, Bell DM, El-Naggar AK, Kies MS, Weber RS, Kupferman ME. Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 139(11):1195-202, 11/2013. e-Pub 9/26/2013. PMID: 24076756.
26. Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity! Adv Anat Pathol 20(6):416-23, 11/2013. PMID: 24113312.
27. Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner H, Bell D, Rosenthal DI, Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN. Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival. Head Neck 35(10):1454-60, 10/2013. e-Pub 9/28/2012. PMID: 23018868.
28. Arduino PG, Bagan J, El-Naggar AK, Carrozzo M. Urban legends series: oral leukoplakia. Oral Dis 19(7):642-59, 10/2013. e-Pub 2/4/2013. PMID: 23379968.
29. Ivanov SV, Panaccione A, Brown B, Guo Y, Moskaluk CA, Wick MJ, Brown JL, Ivanova AV, Issaeva N, El-Naggar AK, Yarbrough WG. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene 32(32):3698-710, 8/8/2013. e-Pub 10/1/2012. PMID: 23027130.
30. Gillenwater AM, Frank SJ, Fatani H, El-Naggar AK. Primary intestinal-like adenocarcinoma of major salivary glands: 2 instances of previously undocumented phenotype. Head Neck 35(8):E234-6, 8/2013. e-Pub 10/29/2012. PMID: 23108630.
31. El-Naggar AK, Kaye FJ, Stenman G. The 3rd Salivary Gland Tumor Workshop meeting report. Head Neck 35(8):1057-60, 8/2013. PMID: 23677839.
32. Mitani Y, Roberts DB, Fatani H, Weber RS, Kies MS, Lippman SM, El-Naggar AK. MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLoS One 8(6):e66778, 2013. e-Pub 6/25/2013. PMCID: PMC3692530.

Invited Articles

1. El-Naggar AK. John g. Batsakis, MD (1929-2013): a historical perspective on his contributions to pathology. Arch Pathol Lab Med 138(11):1424, 11/2014. PMID: 25357103.

Last updated: 7/10/2015