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Adel K. El-Naggar, M.D., Ph.D.

Department of Anatomical Pathology, Division of Pathology-Lab Medicine Div

About Dr. Adel K. El-Naggar

Dr. El-Naggar is a Senior Head and Neck Pathologist and the director of the subspecialty fellowship-training program at The University of Texas M.D. Anderson Cancer Center. Dr. El-Naggar’s clinical and research interests are centered on the optimization of the clinico-pathologic assessment, genomic characterization biomarker discovery and integration of patients with mucosal, thyroid and parathyroid and salivary gland malignancies..

Primary Appointment

Kathryn O'Connor Cancer Research Professor, Division of Pathology-Lab Medicine Div, MD Anderson, Houston, TX

Professor, Department of Pathology, Anatomical, The University of Texas, M.D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Kathryn O'Connor Cancer Research Professor, The University of Texas MD Anderson Cancer Center, Houston, TX

Adjunct Professor, Department of Pathology, Ein-Shams University, Cairo

Professor, Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1978	Department of Immunology, US Naval Research Unit-3 Ein-Shams School of Medicine, Cairo, EG, Mechanism of Cell-Mediated Immunity in Tuberculous Meningitis, Ph.D
1976	Ein-Shams School of Medicine, Cairo, EG, Clinical Pathology - Residency, DMSc
1970	Ein-Shams School of Medicine, Cairo, EG, M.D, MBChB

Postgraduate Training

1986-1987	Fellow, The University of Texas Cancer Center, Houston, Texas
1982-1986	Chief Resident, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio
1981-1982	Research Associate, Vanderbilt University School of Medicine, Nashville, Tennessee
1978-1980	Senior Research Fellow, University of New Mexico, Albuquerque, New Mexico
1975-1978	Doctoral Fellow, US Naval Research Unit - 3, Cairo
1974-1975	Research Fellow, Research Hematology Unit, Ein-Shams School of Medicine, Cairo
1971-1974	Resident, Clinical Pathology University Hospital, Cairo
1970-1971	House Officer, Ein-Shams School of Medicine, Cairo

Licenses & Certifications

1988	Anatomic and Clinical Pathology
1985	Medical Board

Experience & Service

Faculty Academic Appointments

Kenneth D. Muller Professorship, Department of Melanoma Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 1997 - 2020

Associate Professor and Pathologist, Director of Flow Cytometry Section, Department of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, 1991 - 1995

Assistant Professor, Department of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, 1987 - 1991

Guest Scientist, Immunopathology Department, U.S. Naval Medical Research Unit No. 3 (NAMRU 3), Cairo, 1975 - 1978

Instructor in Clinical Pathology, Ein-Shams School of Medicine, Cairo, 1974 - 1975

Administrative Appointments/Responsibilities

Director of the Head and Neck Pathology Fellowship Program, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2002 - Present

Head & Neck Section Chief, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 1998 - 2020

Head and Neck Section Chief, Cell Kinetric and Flow Cytometry, Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1987 - 1998

Other Professional Positions

Kathryn O'Connor Cancer Research Professor, MD Anderson, Houston, TX, 2020 - Present

Co-Chair of the 3rd Salivary Gland Workshop, The University of Texas MD Anderson Cancer Center, Washington, DC, 2012

Panel member, CDMRP Lung Cancer Research Program, unknown, 2009 - Present

Director, Rare Disease Consortium, Philadelphia, PA, 2008 - Present

Member, American College of Radiology Imaging Network (ACRIN), unknown, 2008

Member of the Organizing Committee, 7th International Conference of Head and Neck Cancer, San Francisco, CA, 2008

Organizing Committee, Head and Neck Research Workshop, Bethesda, MD, 2006

External Advisory Board, Head and Neck SPORE Program, University of Pittsburgh, Pittsburgh, PA, 2004 - Present

Co-Chair, Scientific Session, The 6th International HN Cancer Meeting, Washington, DC, 2004

Co-Chair , Molecular Genetic in Solid Tumor, The 6th International Molecular Biology of Cancer, Crete, 2004

External Advisory Board, The Lung PO1 Program, Emory University, Atlanta, GA, 2004 - Present

Chair, Correlative Science and Pathology, (SWOG) Southwest Oncology Group, Bethesda, MD, 2003 - 2007

Member, Head and Neck Executive Committee, (RTOG) Radiation Therapy Oncology Group, Philadelphia, 2001 - Present

Member of Head and Neck Surgery Committee, (RTOG) Radiation Therapy Oncology Group, Philadelphia, PA, 2000 - Present

Pathology and Tissue Banking Committee, (RTOG) Radiation Therapy Oncology Group, Philadelphia, 2000 - Present

External Advisor, Molecular Genetic Center, Kuwait City, 1998 - Present

Oncology Group, Head and Neck, American College of Surgeons - ECOSOG, Chicago, IL, 1998 - 2006

Head and Neck Committee, American College of Radiology Imaging Network (ACRIN), Philadelphia, PA, 1998 - Present

Steering Committee Member NCI, Head and Neck Intergroup, Bethesda, MD, 1998 - Present

Organizing Committee, The International forum for Head and Neck Cancer Research, McLean, VA, 1997 - 1998

Hematopathologist, 1975 - 1976

Extramural Institutional Committee Activities

Member, Member of the Department of Pathology Executive Committee, The University of Texas MD Anderson Cancer Center, 2007 - Present

Member, Institutional Graduate Medical Education (GMEC), The University of Texas MD Anderson Cancer Center, 2007 - Present

Member, GME Institutional Review Subcommittee, The University of Texas MD Anderson Cancer Center, 2007 - Present

Member, PGE Committee, The University of Texas MD Anderson Cancer Center, 2005

Chairman of Endocrine Neoplasia and Hormonal Disorders Department, Search Committee, The University of Texas MD Anderson Cancer Center, 2003 - 2004

Chairman, Head and Neck Surgery Department, Search Committee, The University of Texas MD Anderson Cancer Center, 2002 - 2003

Member, Fellowship Program Committee, The University of Texas MD Anderson Cancer Center, 2000 - Present

Chairman of Hematopathology Department, Search Committee, The University of Texas MD Anderson Cancer Center, 1999 - 2000

Member, Planning Committee for Physician Scientist Program, The University of Texas MD Anderson Cancer Center, 1998 - 1999

Member, Committee on Export of Export of Patient Materials for Commercial Use, The University of Texas MD Anderson Cancer Center, 1998 - 1999

Member, Planning Committee, for the Institutional Research Forum, The University of Texas MD Anderson Cancer Center, 1997 - 1998

Co-Director, Institutional Tissue Procurement Facility, The University of Texas MD Anderson Cancer Center, 1997 - 1999

Member, Institutional Research Direction Committee, The University of Texas MD Anderson Cancer Center, 1995 - 1996

Member, Promotion Committee, The University of Texas MD Anderson Cancer Center, 1994 - 1999

Member, Medical Practice, The University of Texas MD Anderson Cancer Center, 1993 - 1996

Member, Medical Records, The University of Texas MD Anderson Cancer Center, 1991 - 1993

Editorial Activities

Member, Journal of Clinical Medicine, 2025 - Present

Deputy Editor, Diseases & Research, 2024 - Present

Lead Editor, Head and Neck Tumors Classification, 2017

Associate Editor, ENT Pathology, 2011 - Present

Associate Editor, Cancer Reports, 2011 - Present

Associate Editor, Cancer Prevention Research, 2009 - Present

Associate Editor, The Oral Pathology Journal, 2008 - Present

Editor-in-chief, Head and Neck Oncology Journal, 2008 - Present

Associate Editor, Head and Neck Pathology, 2007 - 2009

Associate Editor, Human Pathology, 2006 - Present

Associate Editor, Archives of Pathology and Laboratory Medicine, 2005 - Present

Associate Editor, Head and Neck, 1999 - Present

Associate Editor, Clinical Cancer Research, 1999 - 2022

Associate Editor, Breast Diseases, 1998 - 2005

Associate Editor, Diagnostic Cytopathology, section editor, Molecular Biology, 1998 - 2001

Associate Editor, International Journal of Oncology, 1998 - Present

Associate Editor, Oral Oncology, 1998 - Present

Associate Editor, American Journal of Surgical Pathology, 1996 - Present

Associate Editor, Cancer Molecular Biology, 1995 - Present

Associate Editor, Advances in Surgical Pathology, 1994 - Present

Associate Editor, Oncology Reports, 1994 - 1996

Honors & Awards

2017	Lead Editor, Who Head and Neck Classification Book
2014	Endocrine-Related Cancer Award, Society for Endocrinology
2012 - 2024	Foreign Member of the The Royal Society of Arts and Sciences in Gothenburg, Kungl. Vetenskaps- och Vitterhets-Samhället i Göteborg
2010	Hayes-Martin Memorial Lectureship, The American Head and Neck Surgeons
2007	The American Head and Neck Surgeons, Presidential Citation
1998 - 2024	Katherine D. O'Conner Endowed Professorship in Cancer Research
1997 - 1998	The B. Rothschild Senior Research Scholarship, Curie Institute
1994	Recognition Award, The Mediterranean Society of Tumor Markers
1978	Letter of Merits, US Naval Medical Research, Unit - 3 (NAMRU - 3)

Professional Memberships

VinFuture Prize

2023 - Present

International Head Neck Scientific Group

2010 - Present

Selected Presentations & Talks

Regional Presentations

2024. Salivary Glands: development, tumorigenesis and genomics. Conference. University of Florida College of Medicine. Jacksonville, FL, US.
2015. Morphologic and genomic characteristics of salivary gland malignancies: diagnostic and clinical relevance. Conference. MYU School of Medicine Pathology Grand Rounds. New York, NY, US.

National Presentations

2016. Head and Neck Cancers. Invited. Egyptian foundation for cancer research (EFCR). Luxor, US.

International Presentations

2025. Spatial and Temporal Genomic Heterogeneity of Salivary Adenoid Cystic Carcinoma: Biological and Clinical Implications. Invited. International Conference on Oncology. Rome, IT.
2024. Salivary Adenoid Cystic Carcinoma: Evolution, Heterogeneity and Targeted Therapy. Invited. 28th International Symposium on Molecular Medicine. Guangzhou, CN.
2024. Postdural puncture headache. Invited. The 13th World Gene Convention. Dublin, IE.
2024. Salivary gland carcinomas. Invited. Annual Congress of International Drug Discovery Science & Technology. Shanghai, CN.
2023. Cellular and Genomic Heterogeneity of Salivary Adenoid Cystic Carcinoma: therapeutic implications. Invited. The World Academy of Sciences, Spandidos Publications, and International Polyamines Fountation ONLUS (IPFO). Tivoli, IT.
2023. Molecular Genetivs and Targeted Therapy of Orphan Salivary Gland Cancer. Conference. The World Academy of Sciences , Spandidos Publications, and University of Chile:. Santiago, CL.
2023. Chair Speech - Targeting Androgen Receptor Activation In Salivary Duct Carcinoma. Invited. 12th World Gene Convention-2023. Sapporo, JP.
2022. Molecular Characterization of Adenoid Cystic Carcinoma. Conference. Cancer Congress. Las Vegas, US.
2016. The Nassopharyngeal Carcinoma and Surgical Approach. Invited. University of Constantine. Constantine, DZ.
2016. Classification of Tumours of Endocrine Organs. Invited. World Health Organization - WHO. Lyon, FR.
2015. Surgical Margins: Pearls and Pitfalls. Invited. 5th World Congress OAOO. San Paulo, BR.
2014. Salivary Gland Tumors. Invited. Consensus Conference on Salivary Gland Tumors. Brescia, IT.

Formal Peers

2017. Perspectives on salivary tumorigenesis and the Head & Neck program at MD Anderson Cancer Center. Visiting. Nashville, TN, US.
2017. – Pathobiology of HNC: Visual, Light-Optic and Ancillary Requisites in Surveillance and Early Detection of H & N Epithelial Malignancy. Invited. San Diego, CA, US.
2017. HNSCC Diagnostic Advisory Board Meeting. Visiting. San Diego, CA, US.
2016. Companion Meeting on Salivary Gland Tumor Trials. Visiting. Chicago, IL, US.
2016. ASCO Annual Meeting. Invited. Chicago, IL, US.
2016. Multidisciplinary Management of Oral Cancer. Visiting. Scottsdale, AZ, US.
2016. NRG Head & Neck Surgical Subcommittee Agenda. Visiting. Atlanta, GA, US.
2016. World Health Organization. Visiting, FR.
2015. 1st Congress of Asia Pacific Society of Thyroid Surgery. Visiting.
2015. Cancer Research Group. Visiting. Orlando, FL, US.
2015. 5th World Congress of IAOO. Visiting, BR.
2015. Salivary Gland Meeting. Visiting. Chicago, IL, US.
2014. Molecular characterization of salivary gland cancer: clinical and therapeutic relevance. Visiting, DE.
2013. International Pathology Symposium. Visiting. Riyadh, SA.
2013. ACRIN Meeting. Invited. Hollywood, FL, US.
2013. RDCRN Steering Committee Meeting. Invited. Rockville, MD, US.
2013. Salivary Gland Tumors. Visiting, Nagoya, JP.
2013. RDCRN Steering Committee Meeting. Invited. Rockville, MD, US.
2013. Tumor Progression - II. Visiting. Houston, TX, US.
2013. Tumor Progression - I. Visiting. Houston, TX, US.
2012. International Pathology Symposium. Visiting, SA.
2012. 17th World Congress on Advances in Oncology on Molecular Medicine. Visiting, GR.
2012. 2012 Steering Committee Meeting. Visiting. Rockville, MD, US.
2012. TCGA Head & Neck Workshop. Invited. Chapel Hill, NC, US.
2012. Tumor Board: Pharynx/Larynx. Invited. Toronto, Canada, CA.
2012. 8th International Conference on Head & Neck Cancer Program Committee. Visiting, CA.
2012. 15th Annual Venezuelan Head & Neck Oncology Congress. Visiting, VE.
2012. AEN Larynx / AEN Squamous Tumorigenesis. Invited. Caracas, Venezuela, US.
2012. RTOG Head & Neck Surgical Subcommittee Meeting. Invited. Philadelphia, PA, US.
2012. 3rd Annual Editor's Conference. Visiting. Washington, DC, US.
2012. 2012 Head & Neck Steering Committee Meeting. Visiting. Rockville, MD, US.
2012. 4th Scientific Meeting of HNODS. Visiting. Kissimmee, FL, US.
2012. Scientific Advisory Board Meeting. Visiting. Chicago, IL, US.
2012. ICPN Lecture. Visiting, EG.
2012. Salivary Gland Conference. Visiting. Washington, DC, US.
2012. RTOG Head & Neck Retreat and Pipeline Meeting. Invited. Philadelphia, PA, US.
2012. RTOG January Symposium. Invited. Atlanta, GA, US.
2011. Congress of the Arab Division. Visiting, LB.
2011. Clinical Trials Planning Meeting / Head & Neck Steering Committee Meeting. Visiting. Washington, DC, US.
2011. ACRIN Meeting. Invited. Arlington, VA, US.
2011. Head & Neck Steering Committee Meeting 2. Visiting. Rockville, MD, US.
2011. RTOG Head & Neck Subcommittee Meeting. Invited. Philadelphia, PA, US.
2011. International Clinical Trials. Visiting. Chicago, IL, US.
2011. Otolaryngology Grand Rounds. Visiting. San Francisco, CA, US.
2011. Head & Neck Steering Committee Meeting 1. Visiting. Rockville, MD, US.
2011. 2011 Photonics West. Visiting. San Francisco, CA, US.
2011. RTOG Head & Neck Subcommittee Meeting. Invited. San Diego, CA, US.
2010. AHNS 2010 Research Workshop on Biology Prevention & Treatment of Head & Neck Cancer. Visiting. Arlington, VA, US.
2010. ACRIN Meeting. Invited. Arlington, VA, US.
2010. Annual Meeting of AAO - Head & Neck Surgery. Visiting. Boston, MA, US.
2010. RDCRN Steering Committee Meeting. Invited. Washington, DC, US.
2010. 14th International Thyroid Congress. Visiting, FR.
2010. AMEGN. Invited.
2010. RTOG Meeting. Invited. Philadelphia, PA, US.
2010. Hayes Martin Lecture. Visiting. Houston, TX, US.
2010. Squamous Cell Carcinoma in Fanconi Patients. Visiting. Chicago, IL, US.
2010. MYB-NFIB fusion gene and MYB transcript and protein expression in salivary adenoid cystic carcinoma: incidence and association. Invited. Hinxton, GB.
2010. ACC Sequencing Meeting. Invited, GB.
2010. King Fahad Medical City Conference. Visiting, SA.
2009. ACCRF's Scientific Advisory Board. Visiting. Boston, MA, US.
2009. 14th World Congress on Advances in Oncology. Visiting, GR.
2009. RDCRN 1st Steering Committee Meeting. Invited. Bethesda, MD, US.
2009. RTOG Meeting. Invited. Chicago, IL, US.
2009. Histopathologic and Phenotypic Assessment in the Development and Valdation of Optical Diagnostic Devices for Head and Neck Mucosal Lesions. Visiting. London.
2009. Molecular and Biomarker Role in Multidisplannary Management of Head and Neck Squamous Carcinoma: Current Status and Future Perspectives. Visiting. Lahore, PK.
2009. 1) Salivary Gland Tumor, 2) Controversial Topics in Head and Neck Pathology, 3) Slide Seminar, 4) Thyroid Cancer and 5) Skull Base Tumor. Visiting, SA.
2008. State of Salivary Gland T umor Biorepository. Visiting. Bethesda, MD, US.
2008. HPV. Invited. Washington, DC, US.
2008. 1) Molecular Pathology of Salivary Gland Tumours, 2) Molecular Pathology of HNS Tumorigenesis: Progress and Promise and 3) Slides Seminar. Visiting. Lisbon, PT.
2008. EMT in Head and Neck Squamous Carcinoma. Visiting. Kos, GR.
2008. ACRIN. Invited. Washington, DC, US.
2008. Pathobiology of Head and Neck Squamous Tumorigenesis. Visiting. Athens, GR.
2008. Salivary Gland Tumor. Visiting. Houston, TX, US.
2008. Nuts and Bolts of Tissue Banking and Pathology and Molecular Biomarkers in the Assessment of Salivary Gland Cancer. Visiting. San Francisco, CA, US.
2008. Molecular Alterations in Head and Neck Tumorigenesis: Diagnostic and Biological Implication. Visiting. San Paulo, BR.
2008. Salivary Gland Neoplasms "Current Status of Biomarkers in Clinical Trials of Salivary Carcinoma". Visiting. Houston, TX, US.
2008. Head and Neck Banking and Pathology of Salivary Gland Tumors. Visiting. San Paulo, BR.
2008. Hormonal and Growth Factors Studies in Salivary Duct Carcinoma. Visiting. San Diego, CA, US.
2008. Hormonal and Growth Factors Studies in Salivary Duct Carcinoma. Visiting. Houston, TX, US.
2008. HNSC Phenotypic and Molecular Heterogeneity. Visiting. Houston, TX, US.
2008. (Dr. Diana Bell) Deletion of Chromosome 1p32-p36 Region is the Most Frequent Aberration and a Poor Outcome Predicator in Adenoid Cystic Carcinoma of the Salivary Gland. Visiting. Denver, CO, US.
2008. 1) Phenotypic Manifestations of Head and Neck Sarcomas; 2) Pathology of Sinonasal Cancer; 3) Tissue and Materials Banking; 4) Molecular Diagnosis of Head and Neck Tumors; 5) Slides Seminar; 6) Histogenesis, Pathology and Biology of Salivary Gland Tumors and 7) Thyroid cancer. Visiting, SA.
2008. RTOG. Invited. San Diego, CA, US.
2007. HNSC. Invited. Rockville, MD, US.
2007. Pathology and Tissue Banking. Visiting. Woodland, TX, US.
2007. HN Intergroup. Invited. Bethesda, MD, US.
2007. Advances in Molecular Genetics and Biomarkers of Salivary Neoplasia. Visiting. Philadelphia, PA, US.
2007. Epithelial-Mesenchymal Transition in Head and Neck Squamous Tumorigenesis. Visiting. Creta, GR.
2007. PhenoPath. Invited. Seattle, WA, US.
2007. SPORE. Invited. Baltimore, MD, US.
2007. PhenoPath. Invited. Seattle, WA, US.
2007. SPORE. Invited. Baltimore, MD, US.
2007. Pathology and Tissue Banking. Visiting. Houston, TX, US.
2007. RTOG. Invited. Philadelphia, PA, US.
2007. Molecular Aspects of Salivary Gland Neoplasia. Visiting. Houston, TX, US.
2007. No Presentation. Visiting. San Diego, CA, US.
2007. Unknown Conference. Visiting. Paris, FR.
2007. Molecular Biology of Squamous Cell Carcinoma. Visiting. Cairo, EG.
2007. (Dr. Williams) Epithelial-Mesenchymal Transformation and Invasion in Head and Neck Squamous Carcinoma. Visiting. San Diego, CA, US.
2007. (Dr. Naqvi) Epithelioid Hemangioendothelioma of the Head and Neck: A clinicopathologic and Immunohistochemical Study. Visiting. San Diego, CA, US.
2007. (Dr. Williams) DNA Methylation: A Comparative Study of Methodologies in Salivary Gland Neoplasia. Visiting. San Diego, CA, US.
2007. Epithelial-Mesenchymal Transition in Head and Neck Squamous Tumorigenesis. Visiting. Cold Spring Harbor, NY, US.
2007. RTOG. Invited. Tampa, FL, US.
2006. Overview of Head and Neck Cancer Biology. Visiting. Philadelphia, PA, US.
2006. SWOG. Invited. Seattle, WA, US.
2006. Biomarkers in Salivary Gland malignancies. Visiting. Bethesda, MD, US.
2006. Molecular Diagnosis of Head and Neck Tumors and Molecular Biology of Squamous Cell Carcinoma. Visiting. Montreal, Quebec, CA.
2006. Follicular Carcinoma of the Thyroid: Pathology Controversies. Visiting. Paris, FR.
2006. Analytical Effect of Saliva Processing on Proteomic Screening for Biomarkers in Head and Neck Squamous Carcinoma. Visiting. Chicago, IL, US.
2006. SPORE. Invited. Baltimore, MD, US.
2006. RTOG. Invited. Toronto, CA.
2006. Molecular Biology of Squamous Cell Carcinoma. Visiting. Houston, TX, US.
2006. SWOG. Invited. Salt Lake City, UT, US.
2006. Comparative Saliva Proteomics: Potential Screening Markers for Head and Neck Squamous Carcinoma. Visiting. Atlanta, GA, US.
2006. RTOG. Invited. Miami Beach, FL, US.
2005. Overview of Head and Neck Cancer Biology. Visiting. Philadelphia, PA, US.
2005. Pathology Assessment of Salivary Gland Tumors” “Tissue and Fluid Materials Banking in Cancer Research: Outline for Practical Implementation” “Thyroid Cancer” “Sarcoma Lecture” Prognostics Markers and Diagnostic Dilemma in Patients with Chemo-Radiation. Visiting. Mumbai, IN.
2005. Molecular Markers: Diagnostic and Therapeutic Perspectives. Visiting. Paris, FR.
2005. Case 4 Nasopharynx Cancer. Visiting. Chicago, IL, US.
2005. SPORE. Invited. Washington, US.
2005. Integration of Novel Diagnostic and Prognostic Markers and Traditional Factors in Routine Practice. Visiting. Houston, TX, US.
2005. RTOG. Invited. Philadelphia, PA, US.
2005. Molecular Basis of Head and Neck Tumors. Invited. Jacksonville, FL, US.
2005. Epigenetic Alterations in Head and Neck Cancer Related Genes: Current and Future Propsects. Visiting. Cancum, MX.
2005. RTOG. Invited. Phoenix, AZ, US.
2005. ACOSOG. Invited. San Antonio, TX, US.
2004. HN Intergroup. Invited. Bethesda, MD, US.
2004. Morphology of Head and Neck Sarcomas. Visiting. Brussels, BE.
2004. Molecular Pathology of Sarcomas and Skull Base Tumors. Visiting. Brussels, BE.
2004. Biomarkers Development and Validation in Head and Neck Trials: Pathology Role and Prospective. Invited. Paris, FR.
2004. Grand Round Molecular Pathology of Head and Neck Neoplasms. Invited. Oklahoma City, OK, US.
2004. Molecular Pathology Practice: Present and Future. Visiting. Cleveland, OH, US.
2004. SWOG. Invited. Kansas City, MO, US.
2004. SWOG. Invited. Kansas City, MO, US.
2004. Differential Methylation Status of Tumor associated Genes in Head and Neck Squamous Carcinoma: Incidence and Potential Implications. Visiting. Crete, GR.
2004. HN Intergroup. Invited. Rockville, MD, US.
2004. Novel Estrogen Receptor Coactivator PELP1/MNAR Gene and ERb Expressed in Salivary Duct Adenocarcinoma: Potential Therapeutic Targets” and gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical signi. Visiting. Washington, US.
2004. SPORE. Invited. Baltimore, MD, US.
2004. RTOG. Invited. Washington, US.
2004. ACOSOG. Invited. Chicago, IL, US.
2004. Phenotypic Heterogeneity of Head and Neck Squamous Carcinoma: Evidence for Linear and Stochastic Molecular Linkage. Visiting. Galveston, TX, US.
2004. Biomarker Applications and Validations in Oral Cancer Trials: Present and Future Prospects. Visiting. Bethesda, MD, US.
2004. SWOG. Invited. Huntington Beach, CA, US.
2004. SPORE. Invited. Orlando, FL, US.
2004. Biomarker Identification and Validation in HNSC: Current and Future Prospects. Invited. Atlanta, GA, US.
2004. ACSOG. Invited. Miami, FL, US.
2004. RTOG. Invited. New Orleans, LA, US.
2003. Phenotypic and Biological Heterogeneity: Molecular Diagnostic Implications. Invited. Nashville, TN, US.
2003. Squamous and Carcinoma Variants of the Head and Neck. Visiting. Houston, TX, US.
2003. SWOG. Invited. Seattle, WA, US.
2003. Methylation Analysis of Cancer Related Genes in Head and neck Squamous Carcinoma. Visiting. Crete, GR.
2003. Genetic and Epigenetic Markers in Head and Neck Squamous Carcinoma Detection and Progression. Invited. Olso, NO.
2003. Pathology & Genetics of Head and Neck Tumours. Invited. Lyon, FR.
2003. WHO. Invited. Lyon, FR.
2003. SPORE. Invited. Baltimore, MD, US.
2003. HN Intergroup. Invited. Rockville, MD, US.
2003. Pathologic Diagnosis of Salivary Gland Neoplasms. Visiting. Houston, TX, US.
2003. SWOG. Invited. San Diego, CA, US.
2003. Pathologic Standardization: Promises and Challenges. Invited. Paris, FR.
2003. Dissecting Head and Neck Squamous Tumorigenesis: Present status and Future Prospects. Visiting. Villejuif, FR.
2002. Sixth Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancer. Invited. McLean, VA, US.
2002. SPORE. Invited. Chantilly, VA, US.
2002. Phenotypic and Biological Evaluation of Thyroid Tumors. Visiting. Houston, TX, US.
2001. Pathology Templates. Invited. Rockville, MD, US.
2001. Pearls Grand Round. Invited. Houston, TX, US.
2001. Lung Cancer Pathology and Tissue Banking Issues. Visiting. Cambridge, MA, US.
2001. Molecular Screening of Lower Respiratory Tract Tumors, at What Cost”?. Visiting. Downers Grove, IL, US.
2000. Conventional and Molecular Pathology of Laryngeal Carcinoma. Invited. Boston, MA, US.
2000. Microarray Technology in the Analysis of Solid Tumors: Promise and Prospects. Visiting. Cairo, EG.
2000. Microsatellites markers – pitfalls and guidelines. Invited. Cairo, EG.
2000. In-situ hybridization technologies in clinical practice. Invited. Cairo, EG.
2000. Molecular Alterations in Pulmonary Neoplasm. Invited. Monterrey, MX.
2000. Gene Express Analysis of Head and Neck Squamous Carcinoma. Invited. Paris, FR.
2000. New Technologies Applicable to Cytology. Visiting. Lillehammer, NO.
2000. ENT Seminar. Invited. Lillehammer, NO.
2000. Biomarkers Analysis and Challenges. Invited. Washington, US.
2000. Genetic and Epigenetic Alterations in Head and Neck Squamous Tumorigenesis: Diagnostic and Therapeutic Prospects. Visiting. Jacksonville, FL, US.
2000. Slide Seminar in Head and Neck Tumors. Invited. Jacksonville, FL, US.
2000. Gene Expression Analysis of Upper Respiratory Tract Squamous Tumorigenesis. Visiting. Downers Grove, IL, US.
2000. Pathobiology and Molecular Genetics of Salivary Gland Neoplasms. Visiting. Houston, TX, US.
2000. 1) “Genomics and Cancer Biology” 2) “Epigenetic Modification of p16 Suppressor Gene in Head and Neck Squamous Tumorigenesis. Visiting. Riyadh, SA.
1999. Phenotypic Biomarkers and Genetic Features in Thoracic Cancers. Visiting. Istanbul, TR.
1999. Head and Neck Research Direction Workshop. Invited. Bethesda, MD, US.
1999. Molecular Pathology and Cancer Genomics: Concept and Prospects. Visiting. Augusta, GA, US.
1998. Laser Capture Microdissection in Molecular Genetic Analysis of Cancer. Visiting. Cairo, EG.
1998. Applications of laser Capture Microdissection in Molecular Genetic Analysis of Solid Tumors. Visiting. Brussel, BE.
1998. p16 Inactivation in Head and Neck Squamous Carcinoma. Visiting. McLean, VA, US.
1998. Laser Capture Microdissection in Molecular Genetic Analysis. Invited. Paris, FR.
1998. Imprinting Relaxation of H19 and IgF2 Genes on Chromosome 11p15 in Primary Head and Neck Squamous Carcinoma. Invited. Paris, FR.
1998. Fine Mapping of Chromosome 8p Regions Involved in Early and Invasive Head and Neck Squamous Carcinoma. Invited. Paris, FR.
1998. Epigenetic Alterations Associated Head and Neck Tumorigenesis: Cause or Consequence. Visiting. Kiel, DE.
1997. Apoptosis and Viability Genes in the Evaluation of Mammary Carcinoma. Visiting. Houston, TX, US.
1997. Molecular Genetic Screening of Salivary Gland Tumors: Putative Chromosomal Regions Associated with Their Development and Progression. Invited. Paris, FR.
1997. Microsatellite markers as a tool in the analysis of head and neck premalignant squamous lesions. Invited. Barcelona, ES.
1997. Proliferation and Apoptosis in the Assessment of Solid Tumor Dynamics. Invited. Pamplona, ES.
1997. Sequential Genetic Alterations at Microsatellite Loci in the Development of Head and Neck Squamous Carcinoma. Invited. Paris, FR.
1997. Genetic and Epigenetic Alterations Leading to the Abrogation of p16 in Head and Neck Squamous Tumorigenesis. Invited. Paris, FR.
1997. Cell Proliferation and Death in the Biology of Solid Tumors. Visiting. Gatherberg, MD, US.
1996. Genetic Alterations and Molecular Biology in Human Neoplasia. Visiting. Monterey, MX.
1996. Genetic Alteration in Head and Neck Squamous Oncogenesis. Visiting. Houston, TX, US.
1996. A) Potential Diagnostic and Prognostic Implication of oncogenes and Tumor Suppressor Genes in Squamous Cell Tumorigenesis, B) Neuroendocrine Carcinoma of the Lung. Visiting. Istanbul, TR.
1996. Surgical Pathology and Translational Research. Visiting. Chicago, IL, US.
1996. FISH Technology, Current and Future Prospects. Visiting. Downers Grove, IL, US.
1996. Bcl-2 and Apoptosis Measurement in Solid Tumor. Visiting, EG.
1996. Molecular Alterations in Head and Neck Tumorigenesis. Visiting. Kiel, DE.
1996. Clinical Relevance of Concurrent Bcl-2 and Apoptosis Analysis in Solid Tumor. Visiting. Santa Barbara, CA, US.
1996. Bcl-2 and Apoptosis Analysis by Flow Cytometry in the Assessment of Mammary Carcinoma. Visiting. Paris, FR.
1995. Biological Significance of Apoptosis and Bcl-2 Flow Cytometric Analysis in Human Neoplasia. Visiting. San Antonio, TX, US.
1995. Surgical Pathology -- selected cases. Invited. Cairo, EG.
1995. Molecular Biology. Invited. Cairo, EG.
1995. Flow Cytometric Measurements of Apoptosis and Bcl-2 in Solid Malignancies: Clinical Implications. Visiting. San Antonio, TX, US.
1995. Sequential p53 Mutations in Pre-Invasive and Invasive Head and Neck Squamous Carcinoma. Visiting. Sao Paulo, BR.
1995. Simultaneous DNA and RNA flow Cytometric Analysis in Breast Carcinoma. Visiting. Sao Paulo, BR.
1994. Sequential Genomic Alterations Using Microsatellite Markers in Pre-Invasive and Invasive Head and Neck Squamous Carcinoma. Visiting. Paris, FR.
1994. Oncogenes and Tumor Suppressor Genes in Head and Neck Squamous Carcinoma. Visiting. Athens, GR.
1994. Multiparameter Flow Cytometry in Solid and Lymphoreticular Malignancy Evaluation. Visiting. Monterey, MX.
1994. Cell Proliferation and Death by Flow Cytometry in Solid Tumors. Visiting. Angel Fire, NM, US.
1994. Molecular Genetics in Surgical Pathology of Solid Tumor. Visiting. Morelia, MX.
1993. DNA Analyses by Flow Cytometry in the Assessment of Ovarian Carcinoma. Visiting. Cairo, EG.
1993. Pre-Malignant Lesions of Head and Neck Region. Visiting. Caracas, VE.
1993. Pathological Evaluation of Salivary Gland Neoplasm’s. Visiting. Juarez, MX.
1993. Flow Cytometric DNA Content and Proliferation markers in Modern Surgical Pathology. Visiting. San Jose, CR.
1993. Simultaneous Analysis of DNA and RNA content Analysis in the Evaluation of Hematoreticular and Solid Neoplasm’s. Visiting. Cairo, EG.
1992. Molecular Genetics in Pathology. Visiting. Caracas, VE.
1992. Slide seminar, unusual cases. Invited. Mexico City, MX.
1992. Clinical Implication of DNA Content Heterogeneity in Solid Tumor. Visiting. Cairo, EG.
1991. Head and Neck Pathology slide seminar. Invited. Cleveland, OH, US.
1991. DNA Content Analysis by Flow Cytometry Application and Limitations. Visiting. San Jose, CR.
1991. Head and Neck slide seminar. Invited. Buenos Aires, AR.
1991. Interphase Cytogenetics in Solid Tumor. Visiting. Riyadh, SA.
1990. Acridine Orange Flow Cytometry in the Assessment of Human Neoplasia. Visiting. San Antonio, TX, US.
1990. Surgical Pathology slide seminar. Invited. Cairo, EG.
1989. Cell Kinetics in the Evaluation of Biological Progression of Solid Malignant Tumor. Visiting. Kansas City, KS, US.
1989. Flow Cytometry in Contemporary Clinical Oncology. Visiting. Mexico City, MX.
1989. Multiparameter Flow Cytometric analysis of Solid Human Tumor. Visiting. Santa Barbara, CA, US.
1989. Salivary gland neoplasms -- slide seminar. Invited. Cairo, EG.
1988. Clinical Application of Flow Cytometry. Visiting. Saltio, MX.

Less

Grant & Contract Support

Date:	2025 - 2029
Title:	B7-H4-Targeting with Puxitatug Samrotecan (P-Sam) in Recurrent/Metastatic (R/M) Adenoid Cystic Carcinoma (ACC): Efficacy, Safety, and Biomarker Evaluation
Funding Source:	CPRIT
Role:	Co-I
ID:	FP00026171

Date:	2025 - 2030
Title:	Role of p53 Missense Mutations on Tumorigenesis in Vivo
Funding Source:	NIH
Role:	Co-I
ID:	FP00022528_Res1

Date:	2025 - 2026
Title:	Response to Bcl-2 Inhibitor in Salivary Duct Carcinoma
Funding Source:	DoD
Role:	PI
ID:	FP00023780

Date:	2025 - 2029
Title:	Functional Analysis of Tumor Infiltrating B Cell Repertoire in Metastatic HER2 Breast Cancer Mouse Model
Funding Source:	TX Southern University
Role:	PI
ID:	FP00024226

Date:	2025 - 2030
Title:	PRECISE-OPMD Trial: Preventing Cancer through Intratumoral Strategy and Early Biomarker Evaluation in Oral Potentially Malignant Disorders
Funding Source:	NATIONAL INSTITUTES OF HEALTH
Role:	Other Significant Contributor
ID:	FP00022361

Date:	2024 - 2029
Title:	Harnessing Tumor and Circulating-Free DNA Methylation for Prognosis and Treatment Stratification in Adenoid Cystic Carcinoma
Funding Source:	NIH/NCI
Role:	Co-I
ID:	FP00020722

Date:	2024 - 2029
Title:	Multidimensional atlas of dynamic cellular, morphologic, and microenvironment changes driving progression of oral potentially malignant disorders
Funding Source:	NIH/NCI
Role:	Other Significant Contributor
ID:	FP00021066

Date:	2024 - 2030
Title:	Apoptotic Response Non-coding RNAs as Prognostic Predictors of HPV-Positive Oropharyngeal Cancer Patients
Funding Source:	National Institutes of Health
Role:	Co-I
ID:	FP00019538_Res1

Date:	2024 - 2027
Title:	Immune-Related Determinants of HPV-Associated Oropharyngeal Cancer Outcomes
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Collaborator
ID:	FP00016389_Res1

Date:	2024 - 2027
Title:	Genomic alterations drive a cancer-permissive immune microenvironment in oral premalignancy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I
ID:	FP00019673

Date:	2023 - 2028
Title:	Advancing Head and Neck Cancer Early Detection Through Proteogenomics
Funding Source:	Johns Hopkins University (Subaward-Subcontract)
Role:	PI

Date:	2023 - 2027
Title:	Immuno-inflammatory Response Non-coding RNs as Predictors of HPV Status & Outcome of Oropharyngeal Cancer Patients
Funding Source:	NIH/NCI
Role:	Co-I
ID:	5R01CA236859 / PID11004

Date:	2023 - 2027
Title:	An epigenome-wide association study of apoptosis-specific noncoding RNAs in HPV-associated oropharyngeal cancer
Funding Source:	National Institutes of Health
Role:	Co-I
ID:	FP00016312_Res 1/CA279064

Date:	2022 - 2027
Title:	The Houston Center for Acquired Resistance Research (H-CARR)
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	1U54CA274321-01

Date:	2022 - 2023
Title:	Targeted EZH2 underlying AR activity in salivary duct carcinoma
Funding Source:	Department of Defense (DOD)
Role:	PI

Date:	2022 - 2027
Title:	A Pathway of Tumor Suppression
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	2R01CA047296-34

Date:	2021 - 2024
Title:	CA200674: Characterization and targeting NOTCH activated Adenoid Cystic Carcinoma (ACC)
Funding Source:	USA Medical Research Acq Activity
Role:	Co-I
ID:	W81XWH2110409

Date:	2020 - 2025
Title:	Role of p53 Missense Mutations of Tumorigenesis in Vivo
Funding Source:	NIH/NCI
Role:	Co-I
ID:	2R01-CA082577-21

Date:	2020 - 2025
Title:	Role of p53 Missense Mutations on Tumorigenesis in Vivo
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R01 CA082577 20

Date:	2019 - 2023
Title:	Immuno-inflammatory Response Non-coding RNAs as Predictors of HPV Status & Outcome of Oropharyngeal Cancer Patients
Funding Source:	NIH/NCI
Role:	Co-I
ID:	CA236859-01A1

Date:	2018 - 2022
Title:	A somatic mutant p53 mouse model of metastatic triple negative breast cancer
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I
ID:	RP180313

Date:	2017 - 2018
Title:	Mechanisms of Adenoid Cystic Carcinoma Development and Tumor Maintenance
Funding Source:	NIH/NIDCR
Role:	Co-I
ID:	IR01DE026735-01A1

Date:	2017 - 2020
Title:	Apoptotic Response miRNAs Predict HPV-associated Oropharyngeal Cancer Outcome
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01

Date:	2017 - 2022
Title:	Prognostic Telomere-Associated Biomarkers in Oropharyngeal Cancer Patients
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01

Date:	2016 - 2019
Title:	Identifying vulnerabilities in mutant p53 driven tumorigenesis
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Collaborator
ID:	RP170231

Date:	2014 - 2016
Title:	Role of MYB and MYB-NFIB fusions in Salivary Adenoid Cystic Carcinoma
Funding Source:	NIH/NCI
Role:	Co-I
ID:	5 R21 DE023656-02

Date:	2013 - 2018
Title:	The Ohio State University and MDACC Thyroid Cancer Spore
Funding Source:	NIH/NCI
Role:	Co-I
ID:	5 P50 CA168505 05

Date:	2010 - 2014
Title:	TCGA Head & Neck and Thyroid
Funding Source:	NIH/NCI
Role:	PI
ID:	HHSN26120100047101

Date:	2010 - 2013
Title:	A single nucleotide polymorphism in Mdm2 regulates p53 activity
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Collaborator
ID:	RP100535 03

Date:	2010 - 2014
Title:	Targeting c-Src kinases in Head and Neck Cancer
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R01 CA143369 02

Date:	2009 - 2012
Title:	ARRA: Comprehensive Analysis of Genetic Alterations in Oral Cancer
Funding Source:	NIH/NIDCR
Role:	Collaborator
ID:	5 RC2 DE020958 02

Date:	2009 - 2017
Title:	Salivary Gland Tumor Biorepository
Funding Source:	NIH/NIDCR
Role:	Core Leader
ID:	HHSN268200900039C 02

Date:	2009 - 2017
Title:	Salivary Gland Tumor Biorepository
Funding Source:	NIH/NIDCR
Role:	PI
ID:	HHSN26820090039C 02

Date:	2009 - 2014
Title:	Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R01 CA131274 04

Date:	2008 - 2010
Title:	Cytokine Variants as Predictors of HPV-16 Status & Outcome of Oropharyngeal Cancer
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R03CA135679

Date:	2005 - 2010
Title:	Polarization Spectroscopy and Imaging of Pre-Cancer (PC1)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R01 EB003540 04

Date:	2004 - 2008
Title:	Multispectral Imaging for Oral Cancer Detection
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R21 DE016485 02

Date:	2004 - 2009
Title:	Novel Strategy for Lung Cancer Chemoprevention and Treatment Using Deguelin, a Natural Product
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 R01 CA109520 05

Date:	2004 - 2010
Title:	Molecular-Based Therapy for Oral cancer Prevention (PC-C2)
Funding Source:	NIH/NCI
Role:	PI
ID:	5 PO1 CA106451 05

Date:	2004 - 2011
Title:	Molecular-Based Therapy for Oral Cancer Prevention (PC-C1)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 P01 CA106451 06

Date:	2004 - 2009
Title:	U10 Full Member Application Alliliated with SWOG
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 U10 CA105409 05

Date:	2004 - 2009
Title:	Novel Strategy for Lung Cancer Using IGFBP-2
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 RO1 CA100816 04

Date:	2004 - 2008
Title:	Novel Strategy for Lung Cancer Treatment using IGFBP-3
Funding Source:	OPFR
Role:	Collaborator
ID:	RSG-04-082-01-TBE 04

Date:	2003 - 2010
Title:	VITAL (Vanguard Investigations of Therapeutic Approaches to Lung Cancer) (PC-C)
Funding Source:	Fed
Role:	Collaborator
ID:	W81XWH-04-1-0142 05

Date:	2003 - 2009
Title:	MD Anderson Gynecologic SPORE for Uterine Cancer (PC-B)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 P50 CA09828 05

Date:	2003 - 2009
Title:	Characterization of Leiomyosarcoma and GIST by Genomics
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 RO1 CA098570 04

Date:	2003 - 2008
Title:	Fluorescence Spectroscopy to Detect Oral Neoplasia
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 RO1 CA095604-04

Date:	2002 - 2015
Title:	MD Anderson Cancer Center Head and Neck SPORE(PC-C1)
Funding Source:	NIH/NCI
Role:	Core Leader
ID:	5 P50 CA097007 10

Date:	2002 - 2008
Title:	MD Anderson Cancer Center SPORE in Head and Neck Bridge Funding
Funding Source:	NIH/NCI
Role:	PI
ID:	3 P50 CA097007 05 S1

Date:	2002 - 2008
Title:	MD Anderson Cancer Center SPORE in Head and Neck
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	3 P50 CA097007 05 S2

Date:	2001 - 2008
Title:	The Impact of Smoking on Lung Cancer Chemoprevention (PP-1)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 PO1 CA091844 05

Date:	2001 - 2008
Title:	The Impact of Smoking on Lung Cancer Chemoprevention (PP-3)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 PO1 CA091844 05

Date:	2001 - 2009
Title:	The BESCT (Biology, Education, Screening, Chemoprevention, and Treatment) Lung Cancer Program (PP-3)
Funding Source:	Fed
Role:	Collaborator
ID:	DAMD17-01-1-0689 05

Date:	2001 - 2009
Title:	The BESCT (Biology, Education, Screening, Chemoprevention, and Treatment) Lung Cancer Program (PP-2)
Funding Source:	Fed
Role:	Collaborator
ID:	DAMD17-01-1-0689 05

Date:	1998 - 2011
Title:	Extension of Radiotherapy Research(PP-2)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 P01 CA006294 44

Date:	1997 - 2011
Title:	A Mutational Model for Childhood Cancer (PC-B)
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	5 PO1 CA03436 21

Selected Publications

Peer-Reviewed Articles

Liu, B, Xiong, S, Williams-Villalobo, AE, Chau, GP, Qi, Y, Chen, H, Johnson, C, Chachad, D, McDaniel, JM, Su, X, El-Naggar, AK, Lozano, G, Zhang, Y. Stromal fibroblastic mutant Trp53 promotes mammary tumor development via enhanced secretion of paracrine factors. npj Breast Cancer 12(1), 2026. e-Pub 2026. PMID: 41387465.
Morrissey, RL, McDaniel, JM, Chau, GP, Su, X, Mitheera, V, Chandra, V, Dixon, BR, El-Naggar, AK, Thompson, A, Lozano, G. Elucidating cooperative genetic events in DCIS progression in mutant p53–driven breast cancer. Proceedings of the National Academy of Sciences of the United States of America 123(2), 2026. e-Pub 2026. PMID: 41505521.
Frank, SJ, Busse, PM, Lee, JJ, Rosenthal, D, Hernandez, M, Swanson, DM, Garden, AS, Gunn, GB, Patel, SH, Snider, JW, Ma, DJ, Molitoris, JK, Lee, N, Parvathaneni, U, McDonald, MW, Kalman, NS, Lin, A, Mohammed, N, Henson, CE, Hyde, C, Bajaj, GK, Katz, SR, Dagan, R, Morrison, WH, Reddy, JP, Fuller, C, Shah, SJ, Phan, J, Chronowski, G, Mayo, LL, Sturgis, EM, Ferrarotto, R, Zhu, XR, Zhang, X, Wang, L, Hutcheson, KA, El-Naggar, AK, Moreno, AC, Lee, A, Spiotto, MT, Gross, N, Lai, SY, Liao, JJ, Paly, JJ, Liao, Z, Foote, RL, Bates, JE, Chambers, MS, Chun, SG, Kaiser, A, Lester, SC, Lukens, JN, McGee, LA, Neben-Wittich, MA, Nguyen, Q, Routman, DM, Schlembach, PJ, Skinner, H, Soike, MH, Rwigema, JM, Wiederhold, LR, Blanchard, P, Choi, I, Koong, A, Langendijk, H, Mohan, R, Carlson, BJ, Mapps, A, Sarmiento, JG, Teferra, MY, Bosch, WR, Followill, DS, Taylor, PA, Fuentes, SY, Ning, M, Toumazis, I, Wogan, CF, De Gracia, B, Fink, K, Grippin, A, Ma, J, Pettersen, EA, Sareyeldin, RM, Cronin, C, Muise, S, Johnson, M, Pyfferoen, K, Tranby, BN, Leonard, J, Watkin, S, Eggleston, C, Barrow, B, Wolcott, J, Antonio, J, Brand, J, Cleverdon, A, Drake, M, Peters, E, Small, C, Clark, K, Holder, R. Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA. The Lancet 407(10524):174-184, 2026. e-Pub 2026. PMID: 41391462.
Trinconi Cunha, M, Sewastjanow-Silva, M, Holsinger, F, Garden, AS, El-Naggar, AK, Myers, JN, Lewin, JS, Gillenwater, AM, Lee, JJ, Khuri, F, Diaz Jr, EM, Ferrarotto, R. Chemotherapy alone for stage II–IVa laryngeal squamous cell carcinoma. Cancer 131(23), 2025. e-Pub 2025. PMID: 41250807.
Siqueira, JM, Heguedusch, D, Cunha, MT, Guimares de Sousa, L, Marques-Piubelli, ML, Carvalho, GL, Hoff, CO, Bonini, F, Mitani, Y, Spiotto, MT, Goepfert, RP, Nunes, FD, De Matos, LL, Kowalski, LP, McGrail, DJ, El-Naggar, AK, Ferrarotto, R. Exploring TROP2 expression in oropharyngeal squamous cell carcinoma. Oral Oncology 169, 2025. e-Pub 2025. PMID: 40865331.
Siqueira JM, Heguedusch D, Cunha MT, de Sousa LG, Marques-Piubelli ML, Carvalho GL, Hoff CO, Bonini F, Mitani Y, Spiotto MT, Goepfert R, Nunes FD, Matos LL, Kowalski LP, McGrail DJ, El-Naggar AK, Ferrarotto R. Exploring TROP2 expression in oropharyngeal squamous cell carcinoma: Association with prognosis and tumor immune microenvironment composition. Oral Oncol 169:107634, 2025. e-Pub 2025. PMID: 40865331.
Siqueira, JM, Mitani, Y, Marques-Piubelli, ML, Hoff, CO, Bonini, F, De Sousa, LG, Mitani, M, Carvalho, GL, Nunes, FD, De Matos, LL, Lin, S, Spiotto, MT, Hanna, EY, McGrail, DJ, El-Naggar, AK, Ferrarotto, R. TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype. Journal of Oral Pathology and Medicine 54(8):658-666, 2025. e-Pub 2025. PMID: 40624990.
Mitani, Y, Al-Maghrabi, H, Karpinets, T, Relator, R, Hilder, L, Chen, IY, Goepfert, RP, Bell, D, Zhang, J, Ferrarotto, R, El-Naggar, AK. Comparative transcriptomics of salivary basal cell adenoma and adenocarcinoma sustain linear neoplastic evolution and intertumor heterogeneity. Journal of Pathology 266(3):258-267, 2025. e-Pub 2025. PMID: 40272378.
Jäwert, F, Fehr, A, Persson, M, El-Naggar, AK, Stenman, G, Andersson, MK. Alternative MYB Promoter Activity Is a Potential Prognostic Biomarker in Head and Neck Adenoid Cystic Carcinoma. Head and Neck 47(7):1996-2002, 2025. e-Pub 2025. PMID: 39996285.
Wang L, El-Naggar AK, Ding Q, Yu W, Middleton LP. Pattern of SOX9 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and matrix-producing metaplastic carcinoma of the breast lends support to common biology. Virchows Arch 487(5):993-1002, 2025. e-Pub 2025. PMID: 40583066.
Hoff, CO, Feng, L, Bonini, F, Sousa, LG, Wang, K, Siqueira, JM, Nguyen, Q, El-Naggar, AK, Hofstetter, WL, Sepesi, B, Ferrarotto, R. Survival outcomes of pulmonary metastasis-directed local therapy in adenoid cystic carcinoma. Cancer 131(10), 2025. e-Pub 2025. PMID: 40377125.
Machtay, M, Torres-Saavedra, P, Thorstad, W, Nguyen-Tân, PF, Siu, LL, Holsinger, F, El-Naggar, AK, Chung, CH, Cmelak, AJ, Burtness, B, Bednarz, G, Quon, H, Breen, SL, Gwede, CK, Dicker, AP, Yao, M, Jordan, RC, Dorth, JA, Lee, N, Chan, JW, Dunlap, NE, Bar-Ad, V, Stokes, WA, Chakravarti, A, Sher, DJ, Rao, S, Harris, J, Yom, SS, Le, QT, Bowles, DW, Jones, CU, Krempl, GA, Lominska, C, Ma, DJ, Mell, LK, Raben, A, Samuels, SE, Spencer, S, Takiar, V, Wilke, C, Young, MR. Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer. Journal of Clinical Oncology 43(12):1474-1487, 2025. e-Pub 2025. PMID: 39841939.
Hoff, CO, De Sousa, LG, Bonini, F, Lago, ED, Wang, K, Siqueira, JM, Mitani, Y, El-Naggar, AK, Ferrarotto, R. Clinical Outcomes With Notch Inhibitors in Notch-Activated Recurrent/Metastatic Adenoid Cystic Carcinoma. Cancer medicine 14(5), 2025. e-Pub 2025. PMID: 40025676.
Frade, HC, Qasim, M, Shivaprasad, A, Fuller, GN, El-Naggar, AK, Viswanathan, A, Tremont, I, Majd, NK. Delayed Diagnosis of Amphetamine-Associated CNS Vasculitis Presenting as a Mass Lesion. Annals of Internal Medicine Clinical Cases 4(2), 2025. e-Pub 2025.
Contrera, KJ, Ferrarotto, R, Gunn, GB, Su, SY, Kies, MS, Glisson, BS, Garden, AS, Roberts, DB, Habna, C, Hoff, CO, El-Naggar, AK, Williams, MD, Raza, SM, DeMonte, F, Chen, MM, Chambers, MS, Hanna, EY. Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma. Clinical Cancer Research 31(2):258-265, 2025. e-Pub 2025. PMID: 39531535.
Serrano, A, Rocha, P, Freitas Lima, C, Stewart, A, Zhang, B, Diao, L, Fujimoto, J, Cardnell, R, Lu, W, Khan, KB, Sable, B, Ellison, AR, Wistuba, II, Concannon, KF, Halperin, DM, Czerniak, BA, Sircar, K, Zhang, M, Cargill, KR, Wang, Q, Aparicio, A, Lazar, A, Hernandez, S, Estrella, JS, Ramalingam, P, El-Naggar, AK, Kalhor, N, Gay, CM, Byers, LA, Solis Soto, LM. Delta-like ligand 3 (DLL3) landscape in pulmonary and extra-pulmonary neuroendocrine neoplasms. npj Precision Oncology 8(1), 2024. e-Pub 2024. PMID: 39558076.
McDaniel JM, Morrissey RL, Dibra D, Patel LR, Xiong S, Zhang Y, Chau GP, Su X, Qi Y, El-Naggar AK, Lozano G. p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator. Cancer Res Commun 4(8):1991-2007, 2024. e-Pub 2024. PMID: 38994678.
Karpinets TV, Mitani Y, Chang CC, Wu X, Song X, Flores II, McDaniel LK, Hoballah YM, Veguilla FJ, Ferrarotto R, Colbert LE, Ajami NJ, Jenq RR, Zhang J, Futreal AP, El-Naggar AK. Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers. Sci Rep 14(1):16300, 2024. e-Pub 2024. PMID: 39009605.
Dal Lago, EA, Guimares de Sousa, L, Yang, Z, Hoff, CO, Bonini, F, Sawyer, M, Wang, K, Lewis, WE, Wahid, K, Hanna, EY, El-Naggar, AK, Fuller, C, Kundu, S, Godoy, M, Ferrarotto, R. Prognostic value of tumor volume doubling time in lung-metastatic adenoid cystic carcinoma. Oral Oncology 151, 2024. e-Pub 2024. PMID: 38507991.
Hoff CO, Dal Lago EA, Siqueira JM, de Sousa LG, El-Naggar AK, Ahnert JR, Ferrarotto R. First Use of AXL Targeting in Metastatic, Refractory, Adenoid Cystic Carcinoma: A Case Report. JCO Precis Oncol 8:e2300633, 2024. e-Pub 2024. PMID: 38579194.
Dibra D, Xiong S, Moyer SM, El-Naggar AK, Qi Y, Su X, Kong EK, Korkut A, Lozano G. Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo. Sci Adv 10(7):eadk1835, 2024. e-Pub 2024. PMID: 38354236.
de Sousa, LG, Siqueira, JM, McGrail, DJ, Marques-Piubelli, ML, Neto, FL, Borgogno, SF, Nunes, FD, De Matos, LL, Kowalski, LP, Hoff, CO, Dai, H, Mitani, Y, Li, K, Williams, MD, Lin, S, El-Naggar, AK, Sikora, AG, Burks, JK, Gillison, M, Ferrarotto, R. The immunological milieu of oropharyngeal squamous cell carcinoma (OPC) according to HPV and smoking status and its influence on prognosis. Journal of Clinical Oncology 42(16), 2024. e-Pub 2024.
Klijanienko J, Masliah-Planchon J, Choussy O, Rougier G, Vautrin AD, Lesnik M, Badois N, Ghanem W, Klos J, Le Tourneau C, Marret G, Barnhill R, El-Naggar AK. Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses. Acta Cytol 68(2):107-120, 2024. e-Pub 2024. PMID: 38437817.
Wong SJ, Torres-Saavedra PA, Saba NF, Shenouda G, Bumpous JM, Wallace RE, Chung CH, El-Naggar AK, Gwede CK, Burtness B, Tennant PA, Dunlap NE, Redman R, Stokes WA, Rudra S, Mell LK, Sacco AG, Spencer SA, Nabell L, Yao M, Cury FL, Mitchell DL, Jones CU, Firat S, Contessa JN, Galloway T, Currey A, Harris J, Curran WJ, Le QT. Radiotherapy Plus Cisplatin With or Without Lapatinib for Non-Human Papillomavirus Head and Neck Carcinoma: A Phase 2 Randomized Clinical Trial. JAMA Oncol 9(11):1565-1573, 2023. e-Pub 2023. PMID: 37768670.
Persson M, Andersson MK, Sahlin PE, Mitani Y, Brandwein-Weber MS, Frierson HF, Moskaluk C, Fonseca I, Ferrarotto R, Boecker W, Loening T, El-Naggar AK, Stenman G. Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers. J Pathol 261(3):256-268, 2023. e-Pub 2023. PMID: 37565350.
Siqueira JM, Mitani Y, Hoff CO, Bonini F, Guimaraes de Sousa L, Marques-Piubelli ML, Purushothaman A, Mitani M, Dai H, Lin SY, Spiotto MT, Hanna EY, McGrail DJ, El-Naggar AK, Ferrarotto R. Analysis of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance. Mod Pathol 37(1):100371. e-Pub 2023. PMID: 38015043.
Dibra D, Moyer SM, El-Naggar AK, Qi Y, Su X, Lozano G. Triple-negative breast tumors are dependent on mutant p53 for growth and survival. Proc Natl Acad Sci U S A 120(34):e2308807120, 2023. e-Pub 2023. PMID: 37579145.
Sousa LG, McGrail DJ, Lazar Neto F, Li K, Marques-Piubelli ML, Ferri-Borgogno S, Dai H, Mitani Y, Spardy Burr N, Cooper ZA, Kinneer K, Cortez MA, Lin SY, Bell D, El Naggar A, Burks J, Ferrarotto R. Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors. Clin Cancer Res 29(16):3162-3171, 2023. e-Pub 2023. PMID: 37256648.
Caudell JJ, Torres-Saavedra PA, Rosenthal DI, Axelrod RS, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, El-Naggar AK, Konski AA, Echevarria MI, Dunlap NE, Shenouda G, Singh AK, Beitler JJ, Garsa A, Bonner JA, Garden AS, Algan O, Harris J, Le QT. Long-term update of NRG/RTOG 0522: a randomized phase III trial of concurrent radiation and cisplatin with or without cetuximab in locoregionally advanced head and neck cancer. Int J Radiat Oncol Biol Phys 116(3):533-543, 2023. e-Pub 2023. PMID: 36549347.
Ferrarotto R, Sousa LG, Feng L, Mott F, Blumenschein G, Altan M, Bell D, Bonini F, Li K, Marques-Piubelli ML, Dal Lago EA, Johnson JJ, Mitani Y, Godoy M, Lee A, Kupferman M, Hanna E, Glisson BS, Elamin Y, El-Naggar A. Phase II Clinical Trial of Axitinib and Avelumab in Patients With Recurrent/Metastatic Adenoid Cystic Carcinoma. J Clin Oncol 41(15):2843-2851, 2023. e-Pub 2023. PMID: 36898078.
William WN, Zhang J, Zhao X, Parra ER, Uraoka N, Lin HY, Peng SA, El-Naggar AK, Rodriguez-Canales J, Song J, Gillenwater AM, Wistuba II, Myers JN, Gold KA, Ferrarotto R, Hwu P, Davoli T, Lee JJ, Heymach JV, Papadimitrakopoulou VA, Lippman SM. Spatial PD-L1, immune-cell microenvironment, and genomic copy-number alteration patterns and drivers of invasive-disease transition in prospective oral precancer cohort. Cancer 129(5):714-727, 2023. e-Pub 2023. PMID: 36597662.
Brayer KJ, Kang H, El-Naggar AK, Andreasen S, Homøe P, Kiss K, Mikkelsen L, Heegaard S, Pelaez D, Moeyersoms A, Tse DT, Guo Y, Lee DY, Ness SA. Dominant Gene Expression Profiles Define Adenoid Cystic Carcinoma (ACC) from Different Tissues: Validation of a Gene Signature Classifier for Poor Survival in Salivary Gland ACC. Cancers (Basel) 15(5), 2023. e-Pub 2023. PMID: 36900183.
Johnson FM, Janku F, Gouda MA, Tran HT, Kawedia JD, Schmitz D, Streefkerk H, Lee JJ, Andersen CR, Deng D, Rawal S, Shah PA, El-Naggar AK, Johnson JM, Frederick MJ. Inhibition of the Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib in Loss-of-Function NOTCH1-Mutant Head and Neck Cancer. Oncologist 27(12):1004-e926, 2022. e-Pub 2022. PMID: 36124629.
Persson M, Andersson MK, Mitani Y, Brandwein-Weber MS, Frierson HF, Moskaluk C, Fonseca I, Ferrarotto R, Boecker W, Loening T, El-Naggar AK, Stenman G. Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study. Cancers (Basel) 14(15), 2022. e-Pub 2022. PMID: 35954356.
Xiong S, Chachad D, Zhang Y, Gencel-Augusto J, Sirito M, Pant V, Yang P, Sun C, Chau G, Qi Y, Su X, Whitley EM, El-Naggar AK, Lozano G. Differential gain-of-function activity of three p53 hotspot mutants in vivo. Cancer Res 82(10):1926-1936, 2022. e-Pub 2022. PMID: 35320355.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND. Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res 28(8):1735, 2022. e-Pub 2022. PMID: 35419587.
Sousa LG, Wang K, Torman D, Binks BJ, Rubin ML, Andersen CR, Lewis WE, Rivera MJ, Kaya D, El-Naggar AK, Hanna EY, Esmaeli B, Frank SJ, Bell D, Glisson BS, Rodon J, Meric-Bernstam F, Lee JJ, Ferrarotto R. Treatment patterns and outcomes of palliative systemic therapy in patients with salivary duct carcinoma and adenocarcinoma, not otherwise specified. Cancer 128(3):509-518, 2022. e-Pub 2022. PMID: 34661906.
Symer, DE, Akagi, K, Geiger, HM, Song, Y, Li, G, Emde, AK, Xiao, W, Jiang, B, Corvelo, A, Toussaint, NC, Li, J, Agrawal, A, Ozer, E, El-Naggar, AK, Du, Z, Shewale, JB, Stache-Crain, B, Zucker, M, Robine, N, Coombes, KR, Gillison, M. Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers. Genome research 32(1):55-70, 2022. e-Pub 2022. PMID: 34903527.
Amit M, Liu C, Mansour J, Gleber-Netto FO, Tam S, Baruch EN, Aashiq M, El-Naggar AK, Moreno AC, Rosenthal DI, Glisson BS, Ferrarotto R, Wong MK, Tsai K, Flores ER, Migden MR, Silverman DA, Li G, Khanna A, Goepfert RP, Nagarajan P, Weber RS, Myers JN, Gross ND. Elective neck dissection versus observation in patients with head and neck cutaneous squamous cell carcinoma. Cancer 127(23):4413-4420, 2021. e-Pub 2021. PMID: 34358340.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND. Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res 27(16):4557-4565, 2021. e-Pub 2021. PMID: 34187851.
Karpinets TV, Mitani Y, Liu B, Zhang J, Pytynia KB, Sellen LD, Karagiannis DT, Ferrarotto R, Futreal AP, El-Naggar AK. Whole-genome Sequencing of Common Salivary Gland Carcinomas: Subtype Restricted and Shared Genetic Alterations. Clin Cancer Res 27(14):3960-3969, 2021. e-Pub 2021. PMID: 34011559.
Ford JR, Rubin ML, Frank SJ, Ning J, Debnam JM, Bell D, El-Naggar A, Ferrarotto R, Esmaeli B. Prognostic factors for local recurrence and survival and impact of local treatments on survival in lacrimal gland carcinoma. Br J Ophthalmol 105(6):768-774, 2021. e-Pub 2021. PMID: 32680839.
Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis 10(5):40, 2021. e-Pub 2021. PMID: 33990543.
Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN. Retraction Note to: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer 124(10):1747, 2021. e-Pub 2021. PMID: 33603199.
Tam S, Gajera M, Luo X, Glisson BS, Ferrarotto R, Johnson FM, Mott FE, Gillison ML, Lu C, Le X, Blumenschein GR, Wong MK, Rosenthal DI, Nagarajan P, El-Naggar AK, Midgen MR, Weber RS, Myers JN, Gross ND. Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck. Head Neck 43(5):1592-1603, 2021. e-Pub 2021. PMID: 33522021.
Choi KY, Amit M, Tam S, Bell D, Phan J, Garden AS, Williams MD, Ferrarotto R, El-Naggar AK, Raza SM, DeMonte F, Kupferman ME, Hanna EY, Su SY. Clinical Implication of Diagnostic and Histopathologic Discrepancies in Sinonasal Malignancies. Laryngoscope 131(5):E1468-E1475, 2021. e-Pub 2021. PMID: 32946597.
Amit M, Liu C, Gleber-Netto FO, Kini S, Tam S, Benov A, Aashiq M, El-Naggar AK, Moreno AC, Rosenthal DI, Glisson BS, Ferrarotto R, Wong MK, Migden MR, Baruch EN, Li G, Khanna A, Goepfert RP, Nagarajan P, Weber RS, Myers JN, Gross ND. Inclusion of extranodal extension in the lymph node classification of cutaneous squamous cell carcinoma of the head and neck. Cancer 127(8):1238-1245, 2021. e-Pub 2021. PMID: 33320343.
Wang J, Hu Y, Escamilla-Rivera V, Gonzalez CL, Tang L, Wang B, El-Naggar AK, Myers JN, Caulin C. Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models. Cancers (Basel) 13(6), 2021. e-Pub 2021. PMID: 33806894.
Huang C, Chen L, Savage SR, Eguez RV, Dou Y, Li Y, da Veiga Leprevost F, Jaehnig EJ, Lei JT, Wen B, Schnaubelt M, Krug K, Song X, Cieslik M, Chang HY, Wyczalkowski MA, Li K, Colaprico A, Li QK, Clark DJ, Hu Y, Cao L, Pan J, Wang Y, Cho KC, Shi Z, Liao Y, Jiang W, Anurag M, Ji J, Yoo S, Zhou DC, Liang WW, Wendl M, Vats P, Carr SA, Mani DR, Zhang Z, Qian J, Chen XS, Pico AR, Wang P, Chinnaiyan AM, Ketchum KA, Kinsinger CR, Robles AI, An E, Hiltke T, Mesri M, Thiagarajan M, Weaver AM, Sikora AG, Lubinski J, Wierzbicka M, Wiznerowicz M, Satpathy S, Gillette MA, Miles G, Ellis MJ, Omenn GS, Rodriguez H, Boja ES, Dhanasekaran SM, Ding L, Nesvizhskii AI, El-Naggar AK, Chan DW, Zhang H, Zhang B, Analysis Consortium CPT. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell 39(3):361-379.e16, 2021. e-Pub 2021. PMID: 33417831.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK. Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets. Clin Cancer Res 27(3):852-864, 2021. e-Pub 2021. PMID: 33172898.
Amit M, Liu C, Netto Gleber FO, Kini S, Tam S, Benov A, Aashiq M, El-Naggar AK, Moreno AC, Rosenthal DI, Glisson BS, Ferrarotto R, Wong MK, Migden MR, Li G, Khanna A, Goepfert RP, Nagarajan P, Weber RS, Myers JN, Gross ND. Integrating depth of invasion in T classification improves the prognostic performance of the American Joint Committee on Cancer primary tumor staging system for cutaneous squamous cell carcinoma of the head and neck. Eur J Cancer 144:169-177, 2021. e-Pub 2021. PMID: 33352413.
Gunn GB, Garden AS, Ye R, Ausat N, Dahlstrom KR, Morrison WH, Fuller CD, Phan J, Reddy JP, Shah SJ, Mayo LL, Chun SG, Chronowski GM, Moreno AC, Myers JN, Hanna EY, Esmaeli B, Gillison ML, Ferrarotto R, Hutcheson KA, Chambers MS, Ginsberg LE, El-Naggar AK, Rosenthal DI, Zhu XR, Frank SJ. Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience. Int J Part Ther 8(1):108-118, 2021. e-Pub 2021. PMID: 34285940.
Sherry AD, Pasalic D, Gunn GB, Fuller CD, Phan J, Rosenthal DI, Morrison WH, Sturgis EM, Gross ND, Gillison ML, Ferrarotto R, El-Naggar AK, Garden AS, Frank SJ. Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life. Int J Part Ther 8(1):234-247, 2021. e-Pub 2021. PMID: 34285950.
Vielh P, Balogh Z, Suciu V, Richon C, Job B, Meurice G, Valent A, Lacroix L, Marty V, Motte N, Dessen P, Caillou B, Ghuzlan AA, Bidart JM, Lazar V, Hofman P, Scoazec JY, El-Naggar AK, Schlumberger M. DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms. Cancers (Basel) 12(9), 2020. e-Pub 2020. PMID: 32899953.
Lee DY, Brayer KJ, Mitani Y, Burns EA, Rao PH, Bell D, Williams MD, Ferrarotto R, Pytynia KB, El-Naggar AK, Ness SA. Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma. Cancers (Basel) 12(9), 2020. e-Pub 2020. PMID: 32867110.
Saluja K, Ravishankar S, Ferrarotto R, Zhu H, Pytynia KB, El-Naggar AK. Ectopic ACTH Production and Cushing's Syndrome in a Patient with Parotid Acinic Cell Carcinoma with High-Grade Transformation: Tumor Context and Clinical Implications. Head Neck Pathol 14(2):562-569, 2020. e-Pub 2020. PMID: 31363907.
Mitani Y, Lin SH, Pytynia KB, Ferrarotto R, El-Naggar AK. Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma. Clin Cancer Res 26(5):1175-1184, 2020. e-Pub 2020. PMID: 31772120.
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578(7795):449-454, 2020. e-Pub 2020. PMID: 32051587.
Bell D, Ferrarotto R, Liang L, Goepfert RP, Li J, Ning J, Broaddus R, Weber RS, El-Naggar AK. Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland. Virchows Arch 476(2):295-305, 2020. e-Pub 2020. PMID: 31423558.
Frerich CA, Sedam HN, Kang H, Mitani Y, El-Naggar AK, Ness SA. N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma. Cancers (Basel) 12(1), 2019. e-Pub 2019. PMID: 31877778.
Tam S, Yao CMK, Amit M, Gajera M, Luo X, Treistman R, Khanna A, Aashiq M, Nagarajan P, Bell D, El-Naggar A, Migden M, Wong M, Glisson B, Ferrarotto R, Esmaeli B, Rosenthal D, Li G, Weber RS, Myers JN, Gross ND. Association of Immunosuppression With Outcomes of Patients With Cutaneous Squamous Cell Carcinoma of the Head and Neck. JAMA Otolaryngol Head Neck Surg. e-Pub 2019. PMID: 31804658.
Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest 129(10):4276-4289, 2019. e-Pub 2019. PMID: 31483290.
Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN. Editor's Note: Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer. Clin Cancer Res 25(15):4862, 2019. e-Pub 2019. PMID: 31371312.
Oh SH, Kim WY, Kim JH, Younes MN, El-Naggar AK, Myers JN, Kies M, Cohen P, Khuri F, Hong WK, Lee HY. Editor's Note: Identification of Insulin-Like Growth Factor Binding Protein-3 as a Farnesyl Transferase Inhibitor SCH66336-Induced Negative Regulator of Angiogenesis in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 25(15):4861, 2019. e-Pub 2019. PMID: 31371311.
Aryal NK, Pant V, Wasylishen AR, Rimel BJ, Baseler L, El-Naggar AK, Mutch DG, Goodfellow PJ, Arur S, Lozano G. Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination. Cancer Res 79(10):2662-2668, 2019. e-Pub 2019. PMID: 30914430.
Ibrahim MY, Nunez MI, Harun N, Lee JJ, El-Naggar AK, Ferrarotto R, Wistuba I, Myers J, Glisson BS, William WN. PI3-kinase pathway biomarkers in oral cancer and tumor immune cells. Head Neck 41(3):615-622, 2019. e-Pub 2019. PMID: 30556200.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE. GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. Thyroid 29(2):161-173, 2019. e-Pub 2019. PMID: 30648929.
Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A 116(3):960-969, 2019. e-Pub 2019. PMID: 30593561.
Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 31(12):1770-1786, 2018. e-Pub 2018. PMID: 30140036.
Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun 9(1):3953, 2018. e-Pub 2018. PMID: 30262850.
Saintigny P, Mitani Y, Pytynia KB, Ferrarotto R, Roberts DB, Weber RS, Kies MS, Maity SN, Lin SH, El-Naggar AK. Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Cancer 124(18):3693-3705, 2018. e-Pub 2018. PMID: 30289966.
Ileana Dumbrava E, Smith V, Alfattal R, El-Naggar AK, Penas-Prado M, Tsimberidou AM. Autoimmune Granulomatous Inflammation of Lacrimal Glands and Axonal Neuritis Following Treatment With Ipilimumab and Radiation Therapy. J Immunother 41(7):336-339, 2018. e-Pub 2018. PMID: 29787423.
Tam S, Sandulache VC, Metwalli KA, Rock CD, Eraj SA, Sheu T, El-Naggar AK, Fuller CD, Weber RS, Lai SY. Incompletely treated malignancies of the major salivary gland: Toward evidence-based care. Head Neck 40(8):1630-1638, 2018. e-Pub 2018. PMID: 29734482.
Rito M, Mitani Y, Bell D, Mariano FV, Almalki ST, Pytynia KB, Fonseca I, El-Naggar AK. Frequent and differential mutations of the CYLD gene in basal cell salivary neoplasms: linkage to tumor development and progression. Mod Pathol 31(7):1064-1072, 2018. e-Pub 2018. PMID: 29463883.
Kakudo K, El-Naggar AK, Hodak SP, Khanafshar E, Nikiforov YE, Nosé V, Thompson LDR. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in thyroid tumor classification. Pathol Int 68(6):327-333, 2018. e-Pub 2018. PMID: 29675873.
Saluja K, Thomas J, Zhang S, Sturgis EM, Jain KS, Prieto VG, El-Naggar AK, Bell D. Malignant perivascular epithelioid cell tumor of the oropharynx with strong TFE3 expression mimicking alveolar soft part sarcoma: a case report and review of the literature. Hum Pathol 76:149-155, 2018. e-Pub 2018. PMID: 29208563.
Kamal M, Ng SP, Eraj SA, Rock CD, Pham B, Messer JA, Garden AS, Morrison WH, Phan J, Frank SJ, El-Naggar AK, Johnson JM, Ginsberg LE, Ferrarotto R, Lewin JS, Hutcheson KA, Cardenas CE, Zafereo ME, Lai SY, Hessel AC, Weber RS, Gunn GB, Fuller CD, Mohamed ASR, Rosenthal DI. Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. Oral Oncol 79:1-8, 2018. e-Pub 2018. PMID: 29598944.
Saintigny P, William WN, Foy JP, Papadimitrakopoulou V, Lang W, Zhang L, Fan YH, Feng L, Kim ES, El-Naggar AK, Lee JJ, Mao L, Hong WK, Lingen MW, Lippman SM. Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. J Natl Cancer Inst 110(3), 2018. e-Pub 2018. PMID: 29617836.
Larsson CA, Moyer SM, Liu B, Michel KA, Pant V, Yang P, Wong J, El-Naggar AK, Krahe R, Lozano G. Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration. Proc Natl Acad Sci U S A 115(9):2198-2203, 2018. e-Pub 2018. PMID: 29440484.
Frerich CA, Brayer KJ, Painter BM, Kang H, Mitani Y, El-Naggar AK, Ness SA. Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes. Oncotarget 9(7):7341-7358, 2018. e-Pub 2018. PMID: 29484115.
Ortiz GJ, Li Y, Post SM, Pant V, Xiong S, Larsson CA, El-Naggar AK, Johnson DG, Lozano G. Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes. Oncogene 37(3):332-340, 2018. e-Pub 2018. PMID: 28925402.
Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM, Head, supplement consortium NCSH. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck 39(12):2433-2443, 2017. e-Pub 2017. PMID: 28945296.
Wang J, Xie T, Wang B, William WN, Heymach JV, El-Naggar AK, Myers JN, Caulin C. PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions. Cancer Prev Res (Phila) 10(12):684-693, 2017. e-Pub 2017. PMID: 29018057.
Bell D, El-Naggar AK, Gidley PW. Middle ear adenomatous neuroendocrine tumors: a 25-year experience at MD Anderson Cancer Center. Virchows Arch 471(5):667-672, 2017. e-Pub 2017. PMID: 28547535.
Liu B, Mitani Y, Rao X, Zafereo M, Zhang J, Zhang J, Futreal PA, Lozano G, El-Naggar AK. Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst 109(10), 2017. e-Pub 2017. PMID: 29117356.
Saluja K, Butler RT, Pytynia KB, Zhao B, Karni RJ, Weber RS, El-Naggar AK. Mucoepidermoid carcinoma post-radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association. Hum Pathol 68:189-192, 2017. e-Pub 2017. PMID: 28499545.
Rosenthal DI, Mohamed ASR, Garden AS, Morrison WH, El-Naggar AK, Kamal M, Weber RS, Fuller CD, Peters LJ. Final Report of a Prospective Randomized Trial to Evaluate the Dose-Response Relationship for Postoperative Radiation Therapy and Pathologic Risk Groups in Patients With Head and Neck Cancer. Int J Radiat Oncol Biol Phys 98(5):1002-1011, 2017. e-Pub 2017. PMID: 28721881.
Li J, Mitani Y, Rao PH, Perlaky L, Liu B, Weber RS, El-Naggar AK. Establishment and genomic characterization of primary salivary duct carcinoma cell line. Oral Oncol 69:108-114, 2017. e-Pub 2017. PMID: 28559013.
Weidhaas JB, Harris J, Schaue D, Chen AM, Chin R, Axelrod R, El-Naggar AK, Singh AK, Galloway TJ, Raben D, Wang D, Matthiesen C, Avizonis VN, Manon RR, Yumen O, Nguyen-Tan PF, Trotti A, Skinner H, Zhang Q, Ferris RL, Sidransky D, Chung CH. The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol 3(4):483-491, 2017. e-Pub 2017. PMID: 28006059.
Rabei NH, El-Helaly AM, Farag AH, El-Naggar AK, Etman MK, El-Moteily MM. Intrapartum fetal head circumference and estimated fetal weight as predictors of operative delivery. Int J Gynaecol Obstet 137(1):34-39, 2017. e-Pub 2017. PMID: 28099750.
Truong MT, Zhang Q, Rosenthal DI, List M, Axelrod R, Sherman E, Weber R, Nguyen-Tân PF, El-Naggar A, Konski A, Galvin J, Schwartz D, Trotti A, Silverman C, Singh A, Godette K, Bonner JA, Jones CU, Garden AS, Shenouda G, Matthiesen C, Le QT, Bruner D. Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522. Int J Radiat Oncol Biol Phys 97(4):687-699, 2017. e-Pub 2017. PMID: 27727066.
Panaccione A, Zhang Y, Mi Y, Mitani Y, Yan G, Prasad ML, McDonald WH, El-Naggar AK, Yarbrough WG, Ivanov SV. Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma. Oral Oncol 66:38-45, 2017. e-Pub 2017. PMID: 28249646.
Ferrarotto R, Mitani Y, Diao L, Guijarro I, Wang J, Zweidler-McKay P, Bell D, William WN, Glisson BS, Wick MJ, Kapoun AM, Patnaik A, Eckhardt G, Munster P, Faoro L, Dupont J, Lee JJ, Futreal A, El-Naggar AK, Heymach JV. Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. J Clin Oncol 35(3):JCO2016675264, 2017. e-Pub 2017. PMID: 27870570.
Jiffar T, Yilmaz T, Lee J, Miller Y, Feng L, El-Naggar A, Kupferman ME. Brain derived neutrophic factor (BDNF) coordinates lympho-vascular metastasis through a fibroblast-governed paracrine axis in the tumor microenvironment. Cancer Cell Microenviron 4(2), 2017. e-Pub 2017. PMID: 28966935.
Thakar SD, Sagiv O, Tetzlaff MT, El-Naggar A, Debnam JM, Kandl TJ, Esmaeli B. A 60-year-old woman with an asymptomatic left lacrimal gland mass found incidentally. Digit J Ophthalmol 23(4):27-29, 2017. e-Pub 2017. PMID: 29403339.
Fuller CD, Mohamed AS, Garden AS, Gunn GB, Mulcahy CF, Zafereo M, Phan J, Lai SY, Lewin JS, Hutcheson KA, Frank SJ, Beadle BM, Morrison WH, El-Naggar AK, Kocak-Uzel E, Ginsberg LE, Kies MS, Weber RS, Rosenthal DI. Long-term outcomes after multidisciplinary management of T3 laryngeal squamous cell carcinomas: Improved functional outcomes and survival with modern therapeutic approaches. Head Neck 38(12):1739-1751, 2016. e-Pub 2016. PMID: 27466789.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nose V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncol 2(8):1023-9, 2016. e-Pub 2016. PMID: 27078145.
Sridharan V, Gjini E, Liao X, Chau NG, Haddad RI, Severgnini M, Hammerman P, El-Naggar A, Freeman GJ, Hodi FS, Rodig SJ, Dranoff G, Schoenfeld JD. Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes. Cancer Immunol Res 4(8):679-87, 2016. e-Pub 2016. PMID: 27312343.
Li Z, Gonzalez CL, Wang B, Zhang Y, Mejia O, Katsonis P, Lichtarge O, Myers JN, El-Naggar AK, Caulin C. Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. e-Pub 2016. PMID: 27447534.
Takiar V, Garden AS, Ma D, Morrison WH, Edson M, Zafereo ME, Gunn GB, Fuller CD, Beadle B, Frank SJ, William WN, Kies M, El-Naggar AK, Weber R, Rosenthal DI, Phan J. Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys 95(4):1117-31, 2016. e-Pub 2016. PMID: 27354127.
Jiang W, Mohamed AS, Fuller CD, Kim BY, Tang C, Gunn GB, Hanna EY, Frank SJ, Su SY, Diaz E, Kupferman ME, Beadle BM, Morrison WH, Skinner H, Lai SY, El-Naggar AK, DeMonte F, Rosenthal DI, Garden AS, Phan J. The role of elective nodal irradiation for esthesioneuroblastoma patients with clinically negative neck. Pract Radiat Oncol 6(4):241-7, 2016. e-Pub 2016. PMID: 26979544.
Zafereo ME, Xu L, Dahlstrom KR, Viamonte CA, El-Naggar AK, Wei Q, Li G, Sturgis EM. Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol 56:47-53, 2016. e-Pub 2016. PMID: 27086486.
Saluja K, Rao PH, Myers JN, El-Naggar AK. Novel t(1;3)(q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis. Hum Pathol. e-Pub 2016. PMID: 27085552.
Skinner HD, Giri U, Yang L, Woo SH, Story MD, Pickering CR, Byers LA, Williams MD, El-Naggar A, Wang J, Diao L, Shen L, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV. Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer. Clin Cancer Res. e-Pub 2016. PMID: 27036135.
Takiar V, Ma D, Garden AS, Li J, Rosenthal DI, Beadle BM, Frank SJ, Fuller CD, Gunn GB, Morrison WH, Hutcheson K, El-Naggar AK, Gold KA, Kupferman ME, Phan J. Disease control and toxicity outcomes for T4 carcinoma of the nasopharynx treated with intensity-modulated radiotherapy. Head Neck 38 Suppl 1:E925-33, 2016. e-Pub 2016. PMID: 25994561.
Bell D, Lewis C, El-Naggar AK, Weber RS. Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of the MD Anderson Cancer Center experience. Head Neck 38 Suppl 1:E1312-7, 2016. e-Pub 2016. PMID: 26316332.
Nien HH, Sturgis EM, Kies MS, El-Naggar AK, Morrison WH, Beadle BM, Johnson FM, Gunn GB, Fuller CD, Phan J, Gold KA, Frank SJ, Skinner H, Rosenthal DI, Garden AS. Comparison of systemic therapies used concurrently with radiation for the treatment of human papillomavirus-associated oropharyngeal cancer. Head Neck 38 Suppl 1:E1554-61, 2016. e-Pub 2016. PMID: 26595157.
Jiang W, Chamberlain PD, Garden AS, Kim BY, Ma D, Lo EJ, Bell D, Gunn GB, Fuller CD, Rosenthal DI, Beadle BM, Frank SJ, Morrison WH, El-Naggar AK, Glisson BS, Sturgis EM, Phan J. Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas. Head Neck 38 Suppl 1:E1459-66, 2016. e-Pub 2016. PMID: 26560893.
Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 48(3):265-72, 2016. e-Pub 2016. PMID: 26829750.
William WN, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind JS, Myers J, El-Naggar A, Lippman SM. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol 2(2):209-16, 2016. e-Pub 2016. PMID: 26540028.
Mitani Y, Liu B, Rao P, Borra V, Zafereo M, Weber RS, Kies MS, Lozano G, Futreal A, Caulin C, El-Naggar A. Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res. e-Pub 2015. PMID: 26631609.
Wang Z, Ling S, Rettig E, Sobel R, Tan M, Fertig EJ, Considine M, El-Naggar AK, Brait M, Fakhry C, Ha PK. Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. Oral Oncol 51(12):1120-5, 2015. e-Pub 2015. PMID: 26490796.
Foy JP, Pickering CR, Papadimitrakopoulou VA, Jelinek J, Lin SH, William WN Jr, Frederick MJ, Wang J, Lang W, Feng L, Zhang L, Kim ES, Fan YH, Hong WK, El-Naggar AK, Lee JJ, Myers JN, Issa JP, Lippman SM, Mao L, Saintigny P. New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development. Cancer Prev Res (Phila) 8(11):1027-35, 2015. e-Pub 2015. PMID: 26342026.
Huang AT, Tang C, Bell D, Yener M, Izquierdo L, Frank SJ, El-Naggar AK, Hanna EY, Weber RS, Kupferman ME. Prognostic factors in adenocarcinoma of the salivary glands. Oral Oncol 51(6):610-5, 2015. e-Pub 2015. PMID: 25843792.
Rosenthal DI, Mohamed AS, Weber RS, Garden AS, Sevak PR, Kies MS, Morrison WH, Lewin JS, El-Naggar AK, Ginsberg LE, Kocak-Uzel E, Ang KK, Fuller CD. Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey. Cancer 121(10):1608-19, 2015. e-Pub 2015. PMID: 25586197.
Yu YH, Morales J, Feng L, Lee JJ, El-Naggar AK, Vigneswaran N. CD147 and Ki-67 overexpression confers poor prognosis in squamous cell carcinoma of oral tongue: a tissue microarray study. Oral Surg Oral Med Oral Pathol Oral Radiol 119(5):553-65, 2015. e-Pub 2015. PMID: 25747176.
Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res 75(7):1527-36, 2015. e-Pub 2015. PMID: 25634208.
Shi X, Liu R, Qu S, Zhu G, Bishop J, Liu X, Sun H, Shan Z, Wang E, Luo Y, Yang X, Zhao J, Du J, El-Naggar AK, Teng W, Xing M. Association of TERT promoter mutation 1,295,228 C>T with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer. J Clin Endocrinol Metab 100(4):E632-7, 2015. e-Pub 2015. PMID: 25584719.
Bell D, Ferrarotto R, Fox MD, Roberts D, Hanna EY, Weber RS, El-Naggar AK. Analysis and significance of c-MET expression in adenoid cystic carcinoma of the salivary gland. Cancer Biol Ther 16(6):834-8, 2015. e-Pub 2015. PMID: 25923130.
Henderson YC, Ahn SH, Ryu J, Chen Y, Williams MD, El-Naggar AK, Gagea M, Schweppe R, Haugen B, Lai SY, Clayman GL. Development and Characterization of Six New Human Papillary Thyroid Carcinoma Cell Lines. J Clin Endocrinol Metab:jc20142624. e-Pub 2014. PMID: 25427145.
Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): Recognition and differentiation from conventional leukoplakia and mimics!. Head Neck 36(11):1662-8, 2014. e-Pub 2014. PMID: 24115154.
Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R, Atlas Network CG, Atlas Network CG. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A 111(43):15544-9, 2014. e-Pub 2014. PMID: 25313082.
Fakhry C, Zhang Q, Nguyen-Tan PF, Rosenthal D, El-Naggar A, Garden AS, Soulieres D, Trotti A, Avizonis V, Ridge JA, Harris J, Le QT, Gillison M. Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. J Clin Oncol 32(30):3365-73, 2014. e-Pub 2014. PMID: 24958820.
Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK. Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications. Clin Cancer Res. e-Pub 2014. PMID: 25316813.
Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ. Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma. Clin Cancer Res. e-Pub 2014. PMID: 25303977.
Garden AS, Gunn GB, Hessel A, Beadle BM, Ahmed S, El-Naggar AK, Fuller CD, Byers LA, Phan J, Frank SJ, Morrison WH, Kies MS, Rosenthal DI, Sturgis EM. Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer. Cancer 120(19):3082-8, 2014. e-Pub 2014. PMID: 24898672.
Li J, Perlaky L, Rao P, Weber RS, El-Naggar AK. Development and characterization of salivary adenoid cystic carcinoma cell line. Oral Oncol 50(10):991-9, 2014. e-Pub 2014. PMID: 25086988.
Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, Bonner JA, Harris J, El-Naggar AK, Gillison ML, Jordan RC, Konski AA, Thorstad WL, Trotti A, Beitler JJ, Garden AS, Spanos WJ, Yom SS, Axelrod RS. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32(27):2940-50, 2014. e-Pub 2014. PMID: 25154822.
Takahashi Y, Bell D, Agarwal G, Roberts D, Xie TX, El-Naggar A, Myers JN, Hanna EY. Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma. Head Neck 36(8):1094-102, 2014. e-Pub 2014. PMID: 23836481.
Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A 111(30):11145-50, 2014. e-Pub 2014. PMID: 25024203.
Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, Ward A, Tsai CJ, Ortega Alves MV, Zhou JH, Drummond J, El-Naggar AK, Gibbs R, Weinstein JN, Wheeler DA, Wang J, Frederick MJ, Myers JN. Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res 20(14):3842-8, 2014. e-Pub 2014. PMID: 24874835.
Li Q, Zhang Y, El-Naggar AK, Xiong S, Yang P, Jackson JG, Chau G, Lozano G. Therapeutic Efficacy of p53 Restoration in Mdm2-overexpressing Tumors. Mol Cancer Res 12(6):901-11, 2014. e-Pub 2014. PMID: 24598047.
Bell D, Holsinger FC, Ordonez N, El-Naggar AK. Intestinal-type adenocarcinoma of the larynx: Report of a rare aggressive phenotype and discussion of histogenesis. Head Neck 36(5):E44-7, 2014. e-Pub 2014. PMID: 24038722.
Ow TJ, Hanna EY, Roberts DB, Levine NB, El-Naggar AK, Rosenthal DI, DeMonte F, Kupferman ME. Optimization of long-term outcomes for patients with esthesioneuroblastoma. Head Neck 36(4):524-30, 2014. e-Pub 2014. PMID: 23780581.
Jakob JA, Kies MS, Glisson BS, Kupferman ME, Liu DD, Lee JJ, El-Naggar AK, Gonzalez-Angulo AM, Blumenschein GR. A Phase II study of Gefitinib in Patients with Advanced Salivary Gland Cancers. Head Neck. e-Pub 2014. PMID: 24585506.
Bell D, Hanna EY, Miele L, Roberts D, Weber RS, El-Naggar AK. Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diagn Pathol 18(1):10-3, 2014. e-Pub 2014. PMID: 24238845.
Millare GG, Guha-Thakurta N, Sturgis EM, El-Naggar AK, Debnam JM. Imaging Findings of Head and Neck Dermatofibrosarcoma Protuberans. AJNR Am J Neuroradiol 35(2):373-8, 2014. e-Pub 2014. PMID: 23907249.
Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. e-Pub 2014. PMID: 24469034.
Gelbard A, Hale KS, Takahashi Y, Davies M, Kupferman ME, El-Naggar AK, Myers JN, Hanna EY. Molecular profiling of sinonasal undifferentiated carcinoma. Head Neck 36(1):15-21, 2014. e-Pub 2014. PMID: 23633104.
Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D, Cancer Group IB, Disorders Group ICM, Cancer Group IP, Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife 3, 2014. e-Pub 2014. PMID: 25271376.
Santarpia L, Calin GA, Adam L, Ye L, Fusco A, Giunti S, Thaller C, Paladini L, Zhang X, Jimenez C, Trimarchi F, El-Naggar AK, Gagel RF. A miRNA signature associated with human metastatic medullary thyroid carcinoma. Endocr Relat Cancer 20(6):809-23, 2013. e-Pub 2013. PMID: 24127332.
Neskey DM, Klein JD, Hicks S, Garden AS, Bell DM, El-Naggar AK, Kies MS, Weber RS, Kupferman ME. Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 139(11):1195-202, 2013. e-Pub 2013. PMID: 24076756.
Milbury K, Rosenthal DI, El-Naggar A, Badr H. An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncol 49(11):1067-71, 2013. e-Pub 2013. PMID: 23953777.
Arduino PG, Bagan J, El-Naggar AK, Carrozzo M. Urban legends series: oral leukoplakia. Oral Dis 19(7):642-59, 2013. e-Pub 2013. PMID: 23379968.
Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner H, Bell D, Rosenthal DI, Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN. Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival. Head Neck 35(10):1454-60, 2013. e-Pub 2013. PMID: 23018868.
Ivanov SV, Panaccione A, Brown B, Guo Y, Moskaluk CA, Wick MJ, Brown JL, Ivanova AV, Issaeva N, El-Naggar AK, Yarbrough WG. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene 32(32):3698-710, 2013. e-Pub 2013. PMID: 23027130.
Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, Sun H, El-Naggar AK, Xing M. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer 20(4):603-10, 2013. e-Pub 2013. PMID: 23766237.
Gillenwater AM, Frank SJ, Fatani H, El-Naggar AK. Primary intestinal-like adenocarcinoma of major salivary glands: 2 instances of previously undocumented phenotype. Head Neck 35(8):E234-6, 2013. e-Pub 2013. PMID: 23108630.
Stephens PJ, Davies HR, Mitani Y, Van Loo P, Shlien A, Tarpey PS, Papaemmanuil E, Cheverton A, Bignell GR, Butler AP, Gamble J, Gamble S, Hardy C, Hinton J, Jia M, Jayakumar A, Jones D, Latimer C, McLaren S, McBride DJ, Menzies A, Mudie L, Maddison M, Raine K, Nik-Zainal S, O'Meara S, Teague JW, Varela I, Wedge DC, Whitmore I, Lippman SM, McDermott U, Stratton MR, Campbell PJ, El-Naggar AK, Futreal PA. Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest 123(7):2965-8, 2013. e-Pub 2013. PMID: 23778141.
Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, Zhao M, Ortega Alves MV, Chang K, Drummond J, Cortez E, Xie TX, Zhang D, Chung W, Issa JP, Zweidler-McKay PA, Wu X, El-Naggar AK, Weinstein JN, Wang J, Muzny DM, Gibbs RA, Wheeler DA, Myers JN, Frederick MJ. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov 3(7):770-81, 2013. e-Pub 2013. PMID: 23619168.
Perissinotti AJ, Lee Pierce M, Pace MB, El-Naggar A, Kies MS, Kupferman M. The role of trastuzumab in the management of salivary ductal carcinomas. Anticancer Res 33(6):2587-91, 2013. e-Pub 2013. PMID: 23749912.
Bell D, N Myers J, Rao PH, El-Naggar AK. t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: A putative progression event. Head Neck 35(6):E181-3, 2013. e-Pub 2013. PMID: 22287457.
Zhang L, Mitani Y, Caulin C, Rao PH, Kies MS, Saintigny P, Zhang N, Weber RS, Lippman SM, El-Naggar AK. Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol 182(6):2048-57, 2013. e-Pub 2013. PMID: 23583282.
Guan X, Sturgis EM, Song X, Liu Z, El-Naggar AK, Wei Q, Li G. Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx. Cancer Lett 330(2):233-40, 2013. e-Pub 2013. PMID: 23219900.
Sano D, Gule MK, Rosenthal DI, Bell D, Yates J, El-Naggar AK, Myers JN. Early postoperative epidermal growth factor receptor inhibition: Safety and effectiveness in inhibiting microscopic residual of oral squamous cell carcinoma in vivo. Head Neck 35(3):321-8, 2013. e-Pub 2013. PMID: 22367702.
Mitani Y, Roberts DB, Fatani H, Weber RS, Kies MS, Lippman SM, El-Naggar AK. MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLoS One 8(6):e66778, 2013. e-Pub 2013. PMID: 23825564.
Kies MS, Boatright DH, Li G, Blumenschein G, El-Naggar AK, Brandon Gunn G, Lewin JS, Steinhaus GD, Sturgis EM. Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults. Head Neck 34(9):1255-62, 2012. e-Pub 2012. PMID: 22009800.
El-Naggar AK. Salivary gland cancer: assessing elusive behavior. Expert Rev Endocrinol Metab 7(5):479-481, 2012. e-Pub 2012. PMID: 30780890.
Li N, Xu L, Zhao H, El-Naggar AK, Sturgis EM. A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer 118(16):3945-53, 2012. e-Pub 2012. PMID: 22179977.
McHugh CH, Roberts DB, El-Naggar AK, Hanna EY, Garden AS, Kies MS, Weber RS, Kupferman ME. Prognostic factors in mucoepidermoid carcinoma of the salivary glands. Cancer 118(16):3928-36, 2012. e-Pub 2012. PMID: 22180391.
Jackson JG, Pant V, Li Q, Chang LL, Quintás-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell 21(6):793-806, 2012. e-Pub 2012. PMID: 22698404.
Bhayani MK, Yener M, El-Naggar A, Garden A, Hanna EY, Weber RS, Kupferman ME. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 118(11):2872-8, 2012. e-Pub 2012. PMID: 22020577.
Berinstein NL, Wolf GT, Naylor PH, Baltzer L, Egan JE, Brandwein HJ, Whiteside TL, Goldstein LC, El-Naggar A, Badoual C, Fridman WH, White JM, Hadden JW. Increased lymphocyte infiltration in patients with head and neck cancer treated with the IRX-2 immunotherapy regimen. Cancer Immunol Immunother 61(6):771-82, 2012. e-Pub 2012. PMID: 22057678.
Burch-Smith R, Ordonez NG, Ginsberg LE, Ater JL, El Naggar AK. Oral extragonadal yolk sac tumor in a patient with Aicardi syndrome: putative origin and differential diagnosis. Hum Pathol 43(6):939-42, 2012. e-Pub 2012. PMID: 22225777.
Thariat J, Ang KK, Allen PK, Ahamad A, Williams MD, Myers JN, El-Naggar AK, Ginsberg LE, Rosenthal DI, Glisson BS, Morrison WH, Weber RS, Garden AS. Prediction of neck dissection requirement after definitive radiotherapy for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 82(3):e367-74, 2012. e-Pub 2012. PMID: 22284033.
Xu L, Li G, Wei Q, El-Naggar AK, Sturgis EM. Family history of cancer and risk of sporadic differentiated thyroid carcinoma. Cancer 118(5):1228-35, 2012. e-Pub 2012. PMID: 21800288.
Lewis CM, Glisson BS, Feng L, Wan F, Tang X, Wistuba II, El-Naggar AK, Rosenthal DI, Chambers MS, Lustig RA, Weber RS. A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck. Clin Cancer Res 18(5):1435-46, 2012. e-Pub 2012. PMID: 22261807.
Bell D, Bell A, Roberts D, Weber RS, El-Naggar AK. Developmental transcription factor EN1-a novel biomarker in human salivary gland adenoid cystic carcinoma*. Cancer 118(5):1288-92, 2012. e-Pub 2012. PMID: 21800291.
Galer C, Santillan AA, Chelius D, Huh W, El-Naggar A, Hanna E, Weber RS, Kupferman ME. Minor salivary gland malignancies in the pediatric population. Head Neck. e-Pub 2012. PMID: 22267165.
Sen B, Peng S, Woods DM, Wistuba I, Bell D, El-Naggar AK, Lai SY, Johnson FM. STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. Clin Cancer Res 18(1):127-39, 2012. e-Pub 2012. PMID: 22090359.
Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G. Multiple stress signals activate mutant p53 in vivo. Cancer Res 71(23):7168-75, 2011. e-Pub 2011. PMID: 21983037.
Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C. Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol 225(4):479-89, 2011. e-Pub 2011. PMID: 21952947.
Ryan JT, El-Naggar AK, Huh W, Hanna EY, Weber RS, Kupferman ME. Primacy of surgery in the management of mucoepidermoid carcinoma in children. Head Neck 33(12):1769-73, 2011. e-Pub 2011. PMID: 21284057.
Shin DH, Min HY, El-Naggar AK, Lippman SM, Glisson B, Lee HY. Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody. Mol Cancer Ther 10(12):2437-48, 2011. e-Pub 2011. PMID: 21980128.
Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P, Bowen D, Pellagatti A, Wainscoat JS, Hellstrom-Lindberg E, Gambacorti-Passerini C, Godfrey AL, Rapado I, Cvejic A, Rance R, McGee C, Ellis P, Mudie LJ, Stephens PJ, McLaren S, Massie CE, Tarpey PS, Varela I, Nik-Zainal S, Davies HR, Shlien A, Jones D, Raine K, Hinton J, Butler AP, Teague JW, Baxter EJ, Score J, Galli A, Della Porta MG, Travaglino E, Groves M, Tauro S, Munshi NC, Anderson KC, El-Naggar A, Fischer A, Mustonen V, Warren AJ, Cross NC, Green AR, Futreal PA, Stratton MR, Campbell PJ, Genome Consortium CMDWGOTIC. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 365(15):1384-95, 2011. e-Pub 2011. PMID: 21995386.
Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ, Zhang L, Mitani M, Weber RS, Lippman SM, Caulin C, El-Naggar AK. Novel Chromosomal Rearrangements and breakpoints at the t(6;9) in Salivary Adenoid Cystic Carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res 17(22):7003-7014. e-Pub 2011. PMID: 21976542.
Karpowicz MK, Shalmon B, Molberg KH, El-Naggar AK. Melanoma in a carcinoma ex pleomorphic adenoma of the parotid gland: a case report and putative histogenesis. Hum Pathol 42(9):1355-8, 2011. e-Pub 2011. PMID: 21411120.
Zevallos JP, Jain KS, Roberts D, El-Naggar A, Hanna EY, Kupferman ME. Sinonasal malignancies in children: a 10-year, single-institutional review. Laryngoscope 121(9):2001-3, 2011. e-Pub 2011. PMID: 21739433.
Williams MD, Zhang L, Elliott DD, Perrier ND, Lozano G, Clayman GL, El-Naggar AK. Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. Hum Pathol 42(9):1213-20, 2011. e-Pub 2011. PMID: 21420716.
Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333(6046):1154-7, 2011. e-Pub 2011. PMID: 21798897.
Bell A, Bell D, Weber RS, El-Naggar AK. CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Cancer 117(13):2898-909, 2011. e-Pub 2011. PMID: 21692051.
Jiffar T, Yilmaz T, Lee J, Hanna E, El-Naggar A, Yu D, Myers JN, Kupferman ME. KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma. Oncogene 30(28):3163-73, 2011. e-Pub 2011. PMID: 21383688.
Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and Regulation of the ?N and TAp63 Isoforms in Salivary Gland Tumorigenesis Clinical and Experimental Findings. Am J Pathol 179(1):391-9, 2011. e-Pub 2011. PMID: 21703418.
Brooks HD, Glisson BS, Bekele BN, Johnson FM, Ginsberg LE, El-Naggar A, Culotta KS, Takebe N, Wright J, Tran HT, Papadimitrakopoulou VA. Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma. Cancer 117(10):2112-9, 2011. e-Pub 2011. PMID: 21523723.
Niu J, Huang YJ, Wei S, Liu Z, Wang LE, Chang S, Chamberlain RM, El-Naggar AK, Sturgis EM, Wei Q. Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk. Head Neck 33(5):650-60, 2011. e-Pub 2011. PMID: 20949447.
Ismaiel AA, Ghaly MF, El-Naggar AK. Milk kefir: ultrastructure, antimicrobial activity and efficacy on aflatoxin B1 production by Aspergillus flavus. Curr Microbiol 62(5):1602-9, 2011. e-Pub 2011. PMID: 21350802.
Hong DS, Cabanillas ME, Wheler J, Naing A, Tsimberidou AM, Ye L, Busaidy NL, Waguespack SG, Hernandez M, El Naggar AK, El Naggar AK, Bidyasar S, Wright J, Sherman SI, Kurzrock R. Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies. J Clin Endocrinol Metab 96(4):997-1005, 2011. e-Pub 2011. PMID: 21289252.
Devaney KO, Ferlito A, Rinaldo A, El-Naggar AK, Barnes L. Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: what do we know now that we did not know a decade ago?. Eur Arch Otorhinolaryngol 268(4):477-80, 2011. e-Pub 2011. PMID: 21286737.
Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T, Quintás-Cardama A, Bankson JA, El-Naggar AK, Lozano G. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest 121(3):893-904, 2011. e-Pub 2011. PMID: 21285512.
Saintigny P, Zhang L, Fan YH, El-Naggar AK, Papadimitrakopoulou VA, Feng L, Lee JJ, Kim ES, Ki Hong W, Mao L. Gene expression profiling predicts the development of oral cancer. Cancer Prev Res (Phila) 4(2):218-29, 2011. e-Pub 2011. PMID: 21292635.
Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF, Calvert VS, Fodale V, Wang J, Weber RS. Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am J Pathol 178(2):548-71, 2011. e-Pub 2011. PMID: 21281788.
Galer CE, Corey CL, Wang Z, Younes MN, Gomez-Rivera F, Jasser SA, Ludwig DL, El-Naggar AK, Weber RS, Myers JN. Dual inhibition of epidermal growth factor receptor and insulin-like growth factor receptor I: Reduction of angiogenesis and tumor growth in cutaneous squamous cell carcinoma. Head Neck 33(2):189-98, 2011. e-Pub 2011. PMID: 20848439.
Gomez-Rivera F, El-Naggar AK, Guha-Thakurta N, Kupferman ME. Rheumatoid arthritis mimicking metastatic squamous cell carcinoma. Head Neck Oncol 3:26, 2011. e-Pub 2011. PMID: 21569598.
Jerjes WK, Upile T, Wong BJ, Betz CS, Sterenborg HJ, Witjes MJ, Berg K, van Veen R, Biel MA, El-Naggar AK, Mosse CA, Olivo M, Richards-Kortum R, Robinson DJ, Rosen J, Yodh AG, Kendall C, Ilgner JF, Amelink A, Bagnato V, Barr H, Bolotine L, Bigio I, Chen Z, Choo-Smith LP, D'Cruz AK, Gillenwater A, Leunig A, MacRobert AJ, McKenzie G, Sandison A, Soo KC, Stepp H, Stone N, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Hopper C. The future of medical diagnostics: review paper. Head Neck Oncol 3:38, 2011. e-Pub 2011. PMID: 21861912.
Sethi K, Sarkar S, Das S, Rajput S, Mazumder A, Roy B, Patra S, Mohanty B, El-Naggar AK, Mandal M. Expressions of CK-19, NF-kappaB, E-cadherin, beta-catenin and EGFR as diagnostic and prognostic markers by immunohistochemical analysis in thyroid carcinoma. J Exp Ther Oncol 9(3):187-99, 2011. e-Pub 2011. PMID: 22070050.
Upile T, Jerjes WK, Sterenborg HJ, Wong BJ, El-Naggar AK, Ilgner JF, Sandison A, Witjes MJ, Biel MA, van Veen R, Hamdoon Z, Gillenwater A, Mosse CA, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Barr H, Chen Z, Berg K, D'Cruz AK, Sudhoff H, Stone N, Kendall C, Fisher S, Macrobert AJ, Leunig A, Olivo M, Richards-Kortum R, Soo KC, Bagnato V, Choo-Smith LP, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Bigio I, Yodh AG, Hopper C. At the frontiers of surgery: review. Head Neck Oncol 3(1):7, 2011. e-Pub 2011. PMID: 21306627.
Likhacheva A, Rosenthal DI, Hanna E, Kupferman M, Demonte F, El-Naggar AK. Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome. Head Neck Oncol 3:32, 2011. e-Pub 2011. PMID: 21794118.
Bell D, Roberts D, Kies M, Rao P, Weber RS, El-Naggar AK. Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 116(24):5749-56, 2010. e-Pub 2010. PMID: 20824717.
Lewis CM, Hessel AC, Roberts DB, Guo YZ, Holsinger FC, Ginsberg LE, El-Naggar AK, Weber RS. Prereferral head and neck cancer treatment: compliance with national comprehensive cancer network treatment guidelines. Arch Otolaryngol Head Neck Surg 136(12):1205-11, 2010. e-Pub 2010. PMID: 21173369.
Liu Z, Liu D, Bojdani E, El-Naggar AK, Vasko V, Xing M. IQGAP1 plays an important role in the invasiveness of thyroid cancer. Clin Cancer Res 16(24):6009-18, 2010. e-Pub 2010. PMID: 20959410.
Bell D, Holsinger CF, El-Naggar AK. CRTC1/MAML2 fusion transcript in central mucoepidermoid carcinoma of mandible--diagnostic and histogenetic implications. Ann Diagn Pathol 14(6):396-401, 2010. e-Pub 2010. PMID: 21074686.
Frank SJ, Rosenthal DI, Petsuksiri J, Ang KK, Morrison WH, Weber RS, Glisson BS, Chao KS, Schwartz DL, Chronowski GM, El-Naggar AK, Garden AS. Intensity-Modulated Radiotherapy for Cervical Node Squamous Cell Carcinoma Metastases from Unknown Head-and-Neck Primary Site: M. D. Anderson Cancer Center Outcomes and Patterns of Failure. Int J Radiat Oncol Biol Phys 78(4):1005-10, 2010. e-Pub 2010. PMID: 20207504.
Roblyer D, Kurachi C, Stepanek V, Schwarz RA, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Comparison of multispectral wide-field optical imaging modalities to maximize image contrast for objective discrimination of oral neoplasia. J Biomed Opt 15(6):066017, 2010. e-Pub 2010. PMID: 21198191.
Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK. Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability and Clinicopathological Significance. Clin Cancer Res 16(19):4722-31, 2010. e-Pub 2010. PMID: 20702610.
Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 467(7318):986-90, 2010. e-Pub 2010. PMID: 20962848.
Lo EJ, Bell D, Woo JS, Li G, Hanna EY, El-Naggar AK, Sturgis EM. Human papillomavirus and WHO type I nasopharyngeal carcinoma. Laryngoscope 120(10):1990-7, 2010. e-Pub 2010. PMID: 20824783.
Vadhan-Raj S, Trent J, Patel S, Zhou X, Johnson MM, Araujo D, Ludwig JA, O'Roark S, Gillenwater AM, Bueso-Ramos C, El-Naggar AK, Benjamin RS. Single-dose palifermin prevents severe oral mucositis during multicycle chemotherapy in patients with cancer: a randomized trial. Ann Intern Med 153(6):358-67, 2010. e-Pub 2010. PMID: 20855800.
Hessel AC, Moreno MA, Hanna EY, Roberts DB, Lewin JS, El-Naggar AK, Rosenthal DI, Weber RS. Compliance with quality assurance measures in patients treated for early oral tongue cancer. Cancer 116(14):3408-16, 2010. e-Pub 2010. PMID: 20564059.
Taoudi Benchekroun M, Saintigny P, Thomas SM, El-Naggar AK, Papadimitrakopoulou V, Ren H, Lang W, Fan YH, Huang J, Feng L, Lee JJ, Kim ES, Hong WK, Johnson FM, Grandis JR, Mao L. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila) 3(7):800-9, 2010. e-Pub 2010. PMID: 20570883.
Wei S, Liu Z, Zhao H, Niu J, Wang LE, El-Naggar AK, Sturgis EM, Wei Q. A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. Cancer 116(12):2984-92, 2010. e-Pub 2010. PMID: 20336794.
Liu Z, Li G, Wei S, Niu J, El-Naggar AK, Sturgis EM, Wei Q. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer. e-Pub 2010. PMID: 20549817.
Santarpia L, Myers JN, Sherman SI, Trimarchi F, Clayman GL, El-Naggar AK. Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma. Cancer 116(12):2974-83, 2010. e-Pub 2010. PMID: 20564403.
Byers LA, Holsinger FC, Kies MS, William WN, El-Naggar AK, Lee JJ, Hu J, Lopez A, Tran HT, Yan S, Du Z, Ang KK, Glisson BS, Raso MG, Wistuba II, Myers JN, Hong WK, Papadimitrakopoulou V, Lippman SM, Heymach JV. Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer. Mol Cancer Ther 9(6):1755-63, 2010. e-Pub 2010. PMID: 20530716.
Williams MD, Roberts DB, Kies MS, Mao L, Weber RS, El-Naggar AK. Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance. Clin Cancer Res 16(8):2266-74, 2010. e-Pub 2010. PMID: 20371674.
Civantos FJ, Zitsch RP, Schuller DE, Agrawal A, Smith RB, Nason R, Petruzelli G, Gourin CG, Wong RJ, Ferris RL, El Naggar A, Ridge JA, Paniello RC, Owzar K, McCall L, Chepeha DB, Yarbrough WG, Myers JN. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol 28(8):1395-400, 2010. e-Pub 2010. PMID: 20142602.
Moreno MA, Roberts DB, Kupferman ME, Demonte F, El-Naggar AK, Williams M, Rosenthal DS, Hanna EY. Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer. e-Pub 2010. PMID: 20198705.
Nash JW, Hessel AC, Vigneswaran N, El-Naggar AK. Collagenous myofibroblastic tumor of the mandible: case report of a unique locally aggressive neoplasm. Head Neck Pathol 4(1):44-8, 2010. e-Pub 2010. PMID: 20237988.
Li C, Lu J, Liu Z, Wang LE, Zhao H, El-Naggar AK, Sturgis EM, Wei Q. The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. Cancer Prev Res (Phila Pa) 3(2):246-53, 2010. e-Pub 2010. PMID: 20086182.
Kupferman ME, Jiffar T, El-Naggar A, Yilmaz T, Zhou G, Xie T, Feng L, Wang J, Holsinger FC, Yu D, Myers JN. TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. e-Pub 2010. PMID: 20101235.
Wang LE, Hu Z, Sturgis EM, Spitz MR, Strom SS, Amos CI, Guo Z, Qiao Y, Gillenwater AM, Myers JN, Clayman GL, Weber RS, El-Naggar AK, Mao L, Lippman SM, Hong WK, Wei Q. Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics. Clin Cancer Res 16(2):764-74, 2010. e-Pub 2010. PMID: 20068090.
Kies MS, Holsinger FC, Lee JJ, William WN, Glisson BS, Lin HY, Lewin JS, Ginsberg LE, Gillaspy KA, Massarelli E, Byers L, Lippman SM, Hong WK, El-Naggar AK, Garden AS, Papadimitrakopoulou V. Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol 28(1):8-14, 2010. e-Pub 2010. PMID: 19917840.
Lo EJ, Bell D, Woo J, Li G, Hanna EY, El-Naggar AK, Sturgis EM. Human papillomavirus & WHO type I nasopharyngeal carcinoma. Laryngoscope 120 Suppl 4:S185, 2010. e-Pub 2010. PMID: 21225783.
Hong DS, Sebti SM, Newman RA, Blaskovich MA, Ye L, Gagel RF, Moulder S, Wheler JJ, Naing A, Tannir NM, Ng CS, Sherman SI, El Naggar AK, Khan R, Trent J, Wright JJ, Kurzrock R. Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res 15(22):7061-8, 2009. e-Pub 2009. PMID: 19903778.
Tsao AS, Liu D, Martin J, Tang XM, Lee JJ, El-Naggar AK, Wistuba I, Culotta KS, Mao L, Gillenwater A, Sagesaka YM, Hong WK, Papadimitrakopoulou V. Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res (Phila Pa) 2(11):931-41, 2009. e-Pub 2009. PMID: 19892663.
Saba NF, Choi M, Muller S, Shin HJ, Tighiouart M, Papadimitrakopoulou VA, El-Naggar AK, Khuri FR, Chen ZG, Shin DM. Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prev Res (Phila Pa) 2(9):823-9, 2009. e-Pub 2009. PMID: 19737986.
Lu J, Hu Z, Wei S, Wang LE, Liu Z, El-Naggar AK, Sturgis EM, Wei Q. A Novel Functional Variant (-842G>C) in the PIN1 Promoter Contributes to Decreased Risk of Squamous Cell Carcinoma of the Head and Neck by Diminishing the Promoter Activity. Carcinogenesis. e-Pub 2009. PMID: 19625347.
Nitin N, Rosbach KJ, El-Naggar A, Williams M, Gillenwater A, Richards-Kortum RR. Optical molecular imaging of epidermal growth factor receptor expression to improve detection of oral neoplasia. Neoplasia 11(6):542-51, 2009. e-Pub 2009. PMID: 19484143.
Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med 6(5):e1000068. e-Pub 2009. PMID: 19536326.
Clayman GL, Shellenberger TD, Ginsberg LE, Edeiken BS, El-Naggar AK, Sellin RV, Waguespack SG, Roberts DB, Mishra A, Sherman SI. Approach and safety of comprehensive central compartment dissection in patients with recurrent papillary thyroid carcinoma. Head Neck. e-Pub 2009. PMID: 19360746.
Roblyer D, Kurachi C, Stepanek V, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Objective detection and delineation of oral neoplasia using autofluorescence imaging. Cancer Prev Res (Phila Pa) 2(5):423-31. e-Pub 2009. PMID: 19401530.
Batsakis JG, Ayala A, El Naggar AK. In memoriam: Mario A. Luna, MD. Adv Anat Pathol 16(2):133-4, 2009. e-Pub 2009. PMID: 19685607.
Santarpia L, Sherman SI, Marabotti A, Clayman GL, El-Naggar AK. Detection and molecular characterization of a novel BRAF activated domain mutation in follicular variant of papillary thyroid carcinoma. Hum Pathol. e-Pub 2009. PMID: 19200582.
Chakravarty G, Santillan AA, Galer C, Adams HP, El-Naggar AK, Jasser SA, Mohsin S, Mondal D, Clayman GL, Myers JN. Phosphorylated Insulin like growth factor-I receptor expression and its clinico-pathological significance in histologic subtypes of human thyroid cancer. Exp Biol Med (Maywood), 2009. e-Pub 2009. PMID: 19176870.
Schwarz RA, Gao W, Redden Weber C, Kurachi C, Lee JJ, El-Naggar AK, Richards-Kortum R, Gillenwater AM. Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy. Cancer 115:1669-1679, 2009. e-Pub 2009. PMID: 19170229.
Henderson YC, Shellenberger TD, Williams MD, El-Naggar AK, Fredrick MJ, Cieply KM, Clayman GL. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma. Clin Cancer Res 15:485-491, 2009. e-Pub 2009. PMID: 19147753.
Papadimitrakopoulou V, Izzo JG, Liu DD, Myers J, Ceron TL, Lewin J, William WN, Atwell A, Lee JJ, Gillenwater A, El-Naggar A, Wu X, Lippman SM, Hittelman WN, Hong WK. Cyclin D1 and cancer development in laryngeal premalignancy patients. Cancer Prev Res (Phila Pa) 2:14-21, 2009. e-Pub 2009. PMID: 19139013.
Holsinger FC, Kies MS, Diaz EM, Gillenwater AM, Lewin JS, Ginsberg LE, Glisson BS, Garden AS, Ark N, Lin HY, Lee JJ, El-Naggar AK, Hong WK, Shin DM, Khuri FR. Durable Long-Term Remission With Chemotherapy Alone for Stage II to IV Laryngeal Cancer. J Clin Oncol. e-Pub 2009. PMID: 19289628.
Mithani SK, Shao C, Tan M, Smith IM, Califano JA, El-Naggar AK, Ha PK. Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One 4(12):e8493, 2009. e-Pub 2009. PMID: 20041111.
Cordes B, Williams MD, Tirado Y, Bell D, Rosenthal DI, Al-Dhahri SF, Hanna EY, El-Naggar AK. Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification. Hum Pathol 40:283-292, 2009. e-Pub 2009. PMID: 19150107.
Upile T, Jerjes W, Sterenborg HJ, El-Naggar AK, Sandison A, Witjes MJ, Biel MA, Bigio I, Wong BJ, Gillenwater A, Macrobert AJ, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Mosse CA, Barr H, Chen Z, Berg K, D'Cruz AK, Stone N, Kendall C, Fisher S, Leunig A, Olivo M, Richards-Kortum R, Soo KC, Bagnato V, Choo-Smith LP, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Yodh AG, Hopper C. Head & neck optical diagnostics: vision of the future of surgery. Head Neck Oncol 1(1):25, 2009. e-Pub 2009. PMID: 19594907.
Mazumdar A, Henderson YC, El-Naggar AK, Sen S, Clayman GL. Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma. Head Neck. e-Pub 2008. PMID: 19107951.
Nitin N, Carlson AL, Muldoon T, El-Naggar AK, Gillenwater A, Richards-Kortum R. Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy-glucose. Int J Cancer. e-Pub 2008. PMID: 19173294.
Chen X, Sturgis EM, El-Naggar AK, Wei Q, Li G. Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. Carcinogenesis 29:2120-2125. e-Pub 2008. PMID: 18701437.
Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A 105:13033-13038. e-Pub 2008. PMID: 18728194.
Maitland KC, Gillenwater AM, Williams MD, El-Naggar AK, Descour MR, Richards-Kortum RR. In vivo imaging of oral neoplasia using a miniaturized fiber optic confocal reflectance microscope. Oral Oncol, 2008. e-Pub 2008. PMID: 18396445.
Naqvi J, Ordonez NG, Luna MA, Williams MD, Weber RS, El-Naggar AK. Epithelioid hemangioendothelioma of the head and neck: role of podoplanin in the differential diagnosis. Head Neck Pathol 2(1):25-30, 2008. e-Pub 2008. PMID: 20614338.
Bell D, Luna MA, Weber RS, Kaye FJ, El-Naggar AK. CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer 47:309-314, 2008. e-Pub 2008. PMID: 18181164.
Elliott DD, Sherman SI, Busaidy NL, Williams MD, Santarpia L, Clayman GL, El-Naggar AK. Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification. Hum Pathol 39:15-20, 2008. e-Pub 2008. PMID: 17949783.
Rao PH, Roberts D, Zhao YJ, Bell D, Harris CP, Weber RS, El-Naggar AK. Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res 14:5181-5187, 2008. e-Pub 2008. PMID: 18698036.
Thariat J, Ahamad A, El-Naggar AK, Williams MD, Holsinger FC, Glisson BS, Allen PK, Morrison WH, Weber RS, Ang KK, Garden AS. Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study. Cancer 112:2698-2709, 2008. e-Pub 2008. PMID: 18429002.
Chambers MS, Tomsett KL, Artopoulou II, Garden AS, El-Naggar AK, Martin JW, Keene HJ. Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formation. J Prosthet Dent 100:142-146, 2008. e-Pub 2008. PMID: 18672129.
Choi S, Sano D, Cheung M, Zhao M, Jasser SA, Ryan AJ, Mao L, Chen WT, El-Naggar AK, Myers JN. Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 14:5081-5089, 2008. e-Pub 2008. PMID: 18698025.
Santarpia L, El-Naggar AK, Sherman SI, Hymes SR, Gagel RF, Shaw S, Sarlis NJ. Four patients with cutaneous metastases from medullary thyroid cancer. Thyroid 18:901-905, 2008. e-Pub 2008. PMID: 18651821.
Roblyer D, Richards-Kortum R, Sokolov K, El-Naggar AK, Williams MD, Kurachi C, Gillenwater AM. Multispectral optical imaging device for in vivo detection of oral neoplasia. J Biomed Opt 13:024019, 2008. e-Pub 2008. PMID: 18465982.
Yildirim G, Gillenwater AM, Ordonez NG, Garden AS, El-Naggar AK. Concurrent epithelioid malignant peripheral nerve sheath tumor and papillary thyroid carcinoma in the treated field of Hodgkin's disease. Head Neck 30:675-679, 2008. e-Pub 2008. PMID: 17972308.
Pavlova I, Weber CR, Schwarz RA, Williams M, El-Naggar A, Gillenwater A, Richards-Kortum R. Monte Carlo model to describe depth selective fluorescence spectra of epithelial tissue: applications for diagnosis of oral precancer. J Biomed Opt 13:064012, 2008. e-Pub 2008. PMID: 19123659.
Zhai X, Zhao H, Liu Z, Wang LE, El-Naggar AK, Sturgis EM, Wei Q. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. Clin Cancer Res 14:4345-4352, 2008. e-Pub 2008. PMID: 18594018.
Mishra A, El-Naggar AK, DeMonte F, Hanna EY. Endodermal sinus tumor of the paranasal sinuses. Head Neck 30:539-543, 2008. e-Pub 2008. PMID: 17902152.
Kawaguchi H, El-Naggar AK, Papadimitrakopoulou V, Ren H, Fan YH, Feng L, Lee JJ, Kim E, Hong WK, Lippman SM, Mao L. Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy. J Clin Oncol 26:354-360, 2008. e-Pub 2008. PMID: 18202409.
Mandal M, Myers JN, Lippman SM, Johnson FM, Williams MD, Rayala S, Ohshiro K, Rosenthal DI, Weber RS, Gallick GE, El-Naggar AK. Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. Cancer 112:2088-2100, 2008. e-Pub 2008. PMID: 18327819.
Hong D, Ye L, Gagel R, Chintala L, El Naggar AK, Wright J, Kurzrock R. Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Mol Cancer Ther 7:1001-1006, 2008. e-Pub 2008. PMID: 18445656.
Lee ES, Issa JP, Roberts DB, Williams MD, Weber RS, Kies MS, El-Naggar AK. Quantitative Promoter Hypermethylation Analysis of Cancer-Related Genes in Salivary Gland Carcinomas: Comparison with Methylation-Specific PCR Technique and Clinical Significance. Clin Cancer Res 14:2664-2672, 2008. e-Pub 2008. PMID: 18451230.
Smith SL, Hessel AC, Luna MA, Malpica A, Rosenthal DI, El-Naggar AK. Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients treated at a single institution and comparison with reported series. Arch Otolaryngol Head Neck Surg 134:592-595, 2008. e-Pub 2008. PMID: 18559724.
Chattopadhyay C, El-Naggar AK, Williams MD, Clayman GL. Small molecule c-MET inhibitor PHA665752: Effect on cell growth and motility in papillary thyroid carcinoma. Head Neck 30:991-1000, 2008. e-Pub 2008. PMID: 18327775.
Ohshiro K, Rayala SK, El-Naggar AK, Kumar R. Delivery of cytoplasmic proteins to autophagosomes. Autophagy 4:104-106, 2008. e-Pub 2008. PMID: 18000392.
Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 6:947-954, 2008. e-Pub 2008. PMID: 18567799.
Papadimitrakopoulou VA, William WN, Dannenberg AJ, Lippman SM, Lee JJ, Ondrey FG, Peterson DE, Feng L, Atwell A, El-Naggar AK, Nathan CA, Helman JI, Du B, Yueh B, Boyle JO. Pilot randomized phase II study of celecoxib in oral premalignant lesions. Clin Cancer Res 14:2095-2101, 2008. e-Pub 2008. PMID: 18381950.
Gelbard A, Kupferman ME, Jasser SA, Chen W, El-Naggar AK, Myers JN, Hanna EY. An orthotopic murine model of sinonasal malignancy. Clin Cancer Res 14:7348-7357, 2008. e-Pub 2008. PMID: 19010850.
Ye L, Santarpia L, Cote GJ, El-Naggar AK, Gagel RF. High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma. J Clin Endocrinol Metab 93:4367-4372, 2008. e-Pub 2008. PMID: 18765511.
Santarpia L, El-Naggar AK, Cote GJ, Myers JN, Sherman SI. Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer. J Clin Endocrinol Metab 93:278-284, 2008. e-Pub 2008. PMID: 17989125.
Pavlova I, Williams M, El-Naggar A, Richards-Kortum R, Gillenwater A. Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue. Clin Cancer Res 14:2396-2404, 2008. e-Pub 2008. PMID: 18413830.
Bell D, Zhao YJ, Rao PH, Weber RS, El-Naggar AK. Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue. Head Neck Pathol 1(2):165-8, 2007. e-Pub 2007. PMID: 20614269.
Williams MD, Roberts D, Blumenschein GR, Temam S, Kies MS, Rosenthal DI, Weber RS, El-Naggar AK. Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients. Am J Surg Pathol 31:1645-1652, 2007. e-Pub 2007. PMID: 18059220.
Li C, Hu Z, Lu J, Liu Z, Wang LE, El-Naggar AK, Sturgis EM, Spitz MR, Wei Q. Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. Cancer 110:867-875, 2007. e-Pub 2007. PMID: 17614107.
Chen K, Hu Z, Wang LE, Zhang W, El-Naggar AK, Sturgis EM, Wei Q. Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck. Clin Cancer Res 13:4300-4305, 2007. e-Pub 2007. PMID: 17634560.
Armistead PM, Salganick J, Roh JS, Steinert DM, Patel S, Munsell M, El-Naggar AK, Benjamin RS, Zhang W, Trent JC. Expression of receptor tyrosine kinases and apoptotic molecules in rhabdomyosarcoma: correlation with overall survival in 105 patients. Cancer 110:2293-2303, 2007. e-Pub 2007. PMID: 17896786.
Kaszuba SM, Zafereo ME, Rosenthal DI, El-Naggar AK, Weber RS. Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma. Arch Otolaryngol Head Neck Surg 133:546-550, 2007. e-Pub 2007. PMID: 17576904.
Barnes CJ, Ohshiro K, Rayala SK, El-Naggar AK, Kumar R. Insulin-like growth factor receptor as a therapeutic target in head and neck cancer. Clin Cancer Res 13:4291-4299, 2007. e-Pub 2007. PMID: 17634559.
Hou P, Liu D, Shan Y, Hu S, Studeman K, Condouris S, Wang Y, Trink A, El-Naggar AK, Tallini G, Vasko V, Xing M. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/akt pathway in thyroid cancer. Clin Cancer Res 13:1161-1170, 2007. e-Pub 2007. PMID: 17317825.
Ohshiro K, Rosenthal DI, Koomen JM, Streckfus CF, Chambers M, Kobayashi R, El-Naggar AK. Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma. Int J Oncol 30:743-749, 2007. e-Pub 2007. PMID: 17273777.
An J, Liu Z, Hu Z, Li G, Wang LE, Sturgis EM, El-Naggar AK, Spitz MR, Wei Q. Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev 16:1633-1638, 2007. e-Pub 2007. PMID: 17684138.
Ohshiro K, Rayala SK, Kondo S, Gaur A, Vadlamudi RK, El-Naggar AK, Kumar R. Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Cancer Res 67:8164-8171, 2007. e-Pub 2007. PMID: 17804729.
Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry DJ, Blackburn AC, Peltz G, Amos CI, Lozano G. Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mamm Genome 18:300-309, 2007. e-Pub 2007. PMID: 17557176.
Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, Lang W, Issa JP, Lee JJ, Mao L. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 25:2164-2170, 2007. e-Pub 2007. PMID: 17538160.
Price ND, Trent J, El-Naggar AK, Cogdell D, Taylor E, Hunt KK, Pollock RE, Hood L, Shmulevich I, Zhang W. Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. Proc Natl Acad Sci U S A 104:3414-3419, 2007. e-Pub 2007. PMID: 17360660.
Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer 46:708-715, 2007. e-Pub 2007. PMID: 17437281.
Younes MN, Yigitbasi OG, Yazici YD, Jasser SA, Bucana CD, El-Naggar AK, Mills GB, Myers JN. Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 133:15-23, 2007. e-Pub 2007. PMID: 17224516.
Chen K, Hu Z, Wang LE, Sturgis EM, El-Naggar AK, Zhang W, Wei Q. Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis 28:2008-2012, 2007. e-Pub 2007. PMID: 17693666.
Valentin-Vega YA, Barboza JA, Chau GP, El-Naggar AK, Lozano G. High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Hum Pathol 38:1553-1562, 2007. e-Pub 2007. PMID: 17651783.
Williams MD, Hanna EY, El-Naggar AK. Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:72-75, 2007. e-Pub 2007. PMID: 17577546.
Schafer-Hales K, Iaconelli J, Snyder JP, Prussia A, Nettles JH, El-Naggar A, Khuri FR, Giannakakou P, Marcus AI. Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function. Mol Cancer Ther 6:1317-1328, 2007. e-Pub 2007. PMID: 17431110.
Kim S, Yazici YD, Calzada G, Wang ZY, Younes MN, Jasser SA, El-Naggar AK, Myers JN. Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice. Mol Cancer Ther 6:1785-1792, 2007. e-Pub 2007. PMID: 17575107.
Xiong P, Hu Z, Li C, Wang LE, El-Naggar AK, Sturgis EM, Wei Q. In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck. Int J Cancer 121:2735-2740, 2007. e-Pub 2007. PMID: 17724733.
Lupinetti AD, Roberts DB, Williams MD, Kupferman ME, Rosenthal DI, Demonte F, El-Naggar A, Weber RS, Hanna EY. Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer 110:2726-2731, 2007. e-Pub 2007. PMID: 17960615.
Carlson AL, Gillenwater AM, Williams MD, El-Naggar AK, Richards-Kortum RR. Confocal microscopy and molecular-specific optical contrast agents for the detection of oral neoplasia. Technol Cancer Res Treat 6:361-374, 2007. e-Pub 2007. PMID: 17877424.
Li D, Wang LE, Chang P, El-Naggar AK, Sturgis EM, Wei Q. In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck. Cancer Res 67:5628-5634, 2007. e-Pub 2007. PMID: 17575128.
Wang LE, Li C, Strom SS, Goldberg LH, Brewster A, Guo Z, Qiao Y, Clayman GL, Lee JJ, El-Naggar AK, Prieto VG, Duvic M, Lippman SM, Weber RS, Kripke ML, Wei Q. Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression. Clin Cancer Res 13:6532-6539, 2007. e-Pub 2007. PMID: 17975167.
Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 26:6896-6904, 2007. e-Pub 2007. PMID: 17486075.
Chung CH, Parker JS, Ely K, Carter J, Yi Y, Murphy BA, Ang KK, El-Naggar AK, Zanation AM, Cmelak AJ, Levy S, Slebos RJ, Yarbrough WG. Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-{kappa}B Signaling as Characteristics of a High-risk Head and Neck Squamous Cell Carcinoma. Cancer Res 66:8210-8218, 2006. e-Pub 2006. PMID: 16912200.
Oh SH, Kim WY, Kim JH, Younes MN, El-Naggar AK, Myers JN, Kies M, Cohen P, Khuri F, Hong WK, Lee HY. Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma. Clin Cancer Res 12:653-661, 2006. e-Pub 2006. PMID: 16428512.
Papadimitrakopoulou VA, Brown EN, Liu DD, El-Naggar AK, Jack Lee J, Hong WK, Lee HY. The prognostic role of loss of insulin-like growth factor-binding protein-3 expression in head and neck carcinogenesis. Cancer Lett 239:136-143, 2006. e-Pub 2006. PMID: 16181731.
Hsu ER, Gillenwater AM, Hasan MQ, Williams MD, El-Naggar AK, Richards-Kortum RR. Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent. Int J Cancer 118:3062-3071, 2006. e-Pub 2006. PMID: 16395711.
Chakravarti N, El-Naggar AK, Lotan R, Anderson J, Diwan AH, Saadati HG, Diba R, Prieto VG, Esmaeli B. Expression of retinoid receptors in sebaceous cell carcinoma. J Cutan Pathol 33:10-17, 2006. e-Pub 2006. PMID: 16441406.
Ohshiro K, Rayala SK, Williams MD, Kumar R, El-Naggar AK. Biological role of estrogen receptor beta in salivary gland adenocarcinoma cells. Clin Cancer Res 12:5994-5999, 2006. e-Pub 2006. PMID: 17062671.
Zhang Z, Wang LE, Sturgis EM, El-Naggar AK, Hong WK, Amos CI, Spitz MR, Wei Q. Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck. Clin Cancer Res 12:5596-5602, 2006. e-Pub 2006. PMID: 17000697.
Williams MD, Chakravarti N, Kies MS, Maruya S, Myers JN, Haviland JC, Weber RS, Lotan R, El-Naggar AK. Implications of methylation patterns of cancer genes in salivary gland tumors. Clin Cancer Res 12:7353-7358, 2006. e-Pub 2006. PMID: 17189407.
Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, Lee JJ, Mao L. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer 107:563-569, 2006. e-Pub 2006. PMID: 16804930.
El-Naggar AK. Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. Adv Anat Pathol 13:80-82, 2006. e-Pub 2006. PMID: 16670462.
Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, Myers JN. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Mol Cancer Ther 5:2696-2705, 2006. e-Pub 2006. PMID: 17121916.
Barboza JA, Liu G, Ju Z, El-Naggar AK, Lozano G. p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A 103:19842-19847, 2006. e-Pub 2006. PMID: 17170138.
Nykter M, Hunt KK, Pollock RE, El-Naggar AK, Taylor E, Shmulevich I, Yli-Harja O, Zhang W. Unsupervised analysis uncovers changes in histopathologic diagnosis in supervised genomic studies. Technol Cancer Res Treat 5:177-182, 2006. e-Pub 2006. PMID: 16551137.
Lippman SM, Lee JJ, Martin JW, El-Naggar AK, Xu X, Shin DM, Thomas M, Mao L, Fritsche HA, Zhou X, Papadimitrakopoulou V, Khuri FR, Tran H, Clayman GL, Hittelman WN, Hong WK, Lotan R. Fenretinide activity in retinoid-resistant oral leukoplakia. Clin Cancer Res 12:3109-3114, 2006. e-Pub 2006. PMID: 16707609.
Wang Z, Chakravarty G, Kim S, Yazici YD, Younes MN, Jasser SA, Santillan AA, Bucana CD, El-Naggar AK, Myers JN. Growth-inhibitory effects of human anti-insulin-like growth factor-I receptor antibody (A12) in an orthotopic nude mouse model of anaplastic thyroid carcinoma. Clin Cancer Res 12:4755-465, 2006. e-Pub 2006. PMID: 16899627.
Apisarnthanarax S, Elliott DD, El-Naggar AK, Asper JA, Blanco A, Ang KK, Garden AS, Morrison WH, Rosenthal D, Weber RS, Chao KS. Determining optimal clinical target volume margins in head-and-neck cancer based on microscopic extracapsular extension of metastatic neck nodes. Int J Radiat Oncol Biol Phys 64:678-683, 2006. e-Pub 2006. PMID: 16243444.
Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O, McMurphey A, Ludwick J, El-Naggar AK, Bucana C, Mills GB, Myers JN. The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral Oncol 42:430-439, 2006. e-Pub 2006. PMID: 16442835.
Giri U, Ashorn CL, Ramdas L, Stivers DN, Coombes K, El-Naggar AK, Ang KK, Story MD. Molecular signatures associated with clinical outcome in patients with high-risk head-and-neck squamous cell carcinoma treated by surgery and radiation. Int J Radiat Oncol Biol Phys 64:670-677, 2006. e-Pub 2006. PMID: 16289374.
Younes MN, Yazici YD, Kim S, Jasser SA, El-Naggar AK, Myers JN. Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with NVP-AEE788 for the treatment of aggressive follicular thyroid cancer. Clin Cancer Res 12:3425-3434, 2006. e-Pub 2006. PMID: 16740767.
Simon C, Goepfert H, Rosenthal DI, Roberts D, El-Naggar A, Old M, Diaz EM, Myers JN. Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival. Eur Arch Otorhinolaryngol 263:313-318, 2006. e-Pub 2006. PMID: 16328403.
Jimenez C, Yang Y, Kim HW, Al-Sagier F, Berry DA, El-Naggar AK, Patel S, Vassilopoulou-Sellin R, Gagel RF. Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. J Bone Miner Res 20:1562-1568, 2005. e-Pub 2005. PMID: 16059628.
Massarelli E, Brown E, Tran NK, Liu DD, Izzo JG, Lee JJ, El-Naggar AK, Hong WK, Papadimitrakopoulou VA. Loss of E-cadherin and p27 expression is associated with head and neck squamous tumorigenesis. Cancer 103:952-959, 2005. e-Pub 2005. PMID: 15666322.
Maruya S, Kies MS, Williams M, Myers JN, Weber RS, Batsakis JG, El-Naggar AK. Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications. Hum Pathol 36:821-827, 2005. e-Pub 2005. PMID: 16084953.
Saffari B, Bernstein L, Hong DC, Sullivan-Halley J, Runnebaum IB, Grill HJ, Jones LA, El-Naggar A, Press MF. Association of p53 mutations and a codon 72 single nucleotide polymorphism with lower overall survival and responsiveness to adjuvant radiotherapy in endometrioid endometrial carcinomas. Int J Gynecol Cancer 15:952-963, 2005. e-Pub 2005. PMID: 16174251.
Vielh P, Carton M, Padoy E, de Rycke Y, Klijanienko J, El-Naggar AK, Asselain B. S-phase fraction as an independent prognostic factor of long-term overall survival in patients with early-stage or locally advanced invasive breast carcinoma. Cancer 105:476-482, 2005. e-Pub 2005. PMID: 16116603.
Li J, El-Naggar AK, Mao L. Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. Cancer 104:771-776, 2005. e-Pub 2005. PMID: 15959912.
Neumann AS, Lyons HJ, Shen H, Liu Z, Shi Q, Sturgis EM, Shete S, Spitz MR, El-Naggar A, Hong WK, Wei Q. Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer 115:131-136, 2005. e-Pub 2005. PMID: 15688408.
Schiff BA, Roberts DB, El-Naggar A, Garden AS, Myers JN. Selective vs modified radical neck dissection and postoperative radiotherapy vs observation in the treatment of squamous cell carcinoma of the oral tongue. Arch Otolaryngol Head Neck Surg 131:874-878, 2005. e-Pub 2005. PMID: 16230589.
Massarelli E, Liu DD, Lee JJ, El-Naggar AK, Lo Muzio L, Staibano S, De Placido S, Myers JN, Papadimitrakopoulou VA. Akt activation correlates with adverse outcome in tongue cancer. Cancer 104:2430-2436, 2005. e-Pub 2005. PMID: 16245318.
Diaz EM, Johnigan RH, Pero C, El-Naggar AK, Roberts DB, Barker JL, DeMonte F. Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. Head Neck 27:138-149, 2005. e-Pub 2005. PMID: 15654688.
Moore BA, Weber RS, Prieto V, El-Naggar AK, Holsinger FC, Zhou X, Lee JJ, Lippman S, Clayman GL. Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Laryngoscope 115:1561-1567, 2005. e-Pub 2005. PMID: 16148695.
Baker H, Patel V, Molinolo AA, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-García A, Myers JN, El-Naggar AK, Gutkind JS, Hancock WS. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol 41:183-199, 2005. e-Pub 2005. PMID: 15695121.
Maruya SI, Myers JN, Weber RS, Rosenthal DI, Lotan R, El-Naggar AK. ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!. Oral Oncol 41:580-588, 2005. e-Pub 2005. PMID: 15975520.
Backous DD, DeMonte F, El-Naggar AK, Wolf P, Weber RS. Craniofacial resection for nonmelanoma skin cancer of the head and neck. Laryngoscope 115:931-937, 2005. e-Pub 2005. PMID: 15933497.
Vadlamudi RK, Balasenthil S, Sahin AA, Kies M, Weber RS, Kumar R, El-Naggar AK. Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets. Hum Pathol 36:670-675, 2005. e-Pub 2005. PMID: 16021574.
Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, Dakak Yazici Y, Schiff BA, El-Naggar AK, Bekele BN, Mills GB, Myers JN. Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Mol Cancer Ther 4:1146-1156, 2005. e-Pub 2005. PMID: 16093430.
Yom SS, Machtay M, Biel MA, Sinard RJ, El-Naggar AK, Weber RS, Rosenthal DI. Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx. Am J Clin Oncol 28:385-392, 2005. e-Pub 2005. PMID: 16062081.
Gillenwater A, Lewin J, Roberts D, El-Naggar AK. Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: a clinically aggressive tumor. Laryngoscope 115:1191-1195, 2005. e-Pub 2005. PMID: 15995505.
Jayakumar A, Kang Y, Henderson Y, Mitsudo K, Liu X, Briggs K, Wang M, Frederick MJ, El-Naggar AK, Bebök Z, Clayman GL. Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch Biochem Biophys 435:89-102, 2005. e-Pub 2005. PMID: 15680911.
Marcus AI, Zhou J, O'Brate A, Hamel E, Wong J, Nivens M, El-Naggar AK, Yao TP, Khuri FR, Giannakakou P. The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res 65:3883-3893, 2005. e-Pub 2005. PMID: 15867388.
Chakravarti N, Saadati HG, El-Naggar AK, Lotan R, Diba RE, Esmaeli B. Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid. Ophthal Plast Reconstr Surg 21:292-297, 2005. e-Pub 2005. PMID: 16052143.
Clayman GL, Lee JJ, Holsinger FC, Zhou X, Duvic M, El-Naggar AK, Prieto VG, Altamirano E, Tucker SL, Strom SS, Kripke ML, Lippman SM. Mortality risk from squamous cell skin cancer. J Clin Oncol 23:759-765, 2005. e-Pub 2005. PMID: 15681519.
Glisson B, Colevas AD, Haddad R, Krane J, El-Naggar AK, Kies M, Costello R, Summey C, Arquette M, Langer C, Amrein PC, Posner M. HER2 expression in salivary gland carcinomas: dependence on histological subtype. Clin Cancer Res 10:944-946, 2004. e-Pub 2004. PMID: 14871971.
Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 36:63-68, 2004. e-Pub 2004. PMID: 14702042.
Jimenez C, Habra MA, Huang SC, El-Naggar AK, Shapiro SE, Evans DB, Cote G, Gagel RF. Pheochromocytoma and medullary thyroid carcinoma: a new genotype-phenotype correlation of the RET protooncogene 891 germline mutation. J Clin Endocrinol Metab 89:4142-4145, 2004. e-Pub 2004. PMID: 15292360.
Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN. Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer. Clin Cancer Res 10:8594-8602, 2004. e-Pub 2004. PMID: 15623643.
Fung KM, Diaz EM, Jr, El-Naggar AK, Luna MA. Malignant rhabdoid tumor arising from a pleomorphic adenoma. Ann Diagn Pathol 8:156-161, 2004. e-Pub 2004. PMID: 15185263.
Esmaeli B, Ahmadi MA, Youssef A, Diba R, Amato M, Myers JN, Kies M, El-Naggar A. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg 20:22-26, 2004. e-Pub 2004. PMID: 14752305.
Maruya S, Kim HW, Weber RS, Lee JJ, Kies M, Luna MA, Batsakis JG, El-Naggar AK. Gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical significance. J Mol Diagn 6:180-190, 2004. e-Pub 2004. PMID: 15269293.
Hsu ER, Anslyn EV, Dharmawardhane S, Alizadeh-Naderi R, Aaron JS, Sokolov KV, El-Naggar AK, Gillenwater AM, Richards-Kortum RR. A far-red fluorescent contrast agent to image epidermal growth factor receptor expression. Photochem Photobiol 79:272-279, 2004. e-Pub 2004. PMID: 15115300.
Rosenthal DI, Barker JL, Jr, El-Naggar AK, Glisson BS, Kies MS, Diaz EM, Jr, Clayman GL, Demonte F, Selek U, Morrison WH, Ang KK, Chao KS, Garden AS. Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer 101:2567-2573, 2004. e-Pub 2004. PMID: 15517582.
Jayakumar A, Kang Y, Mitsudo K, Henderson Y, Frederick MJ, Wang M, El-Naggar AK, Marx UC, Briggs K, Clayman GL. Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A. Protein Expr Purif 35:93-101, 2004. e-Pub 2004. PMID: 15039071.
Yom SS, Rashid A, Rosenthal DI, Elliott DD, Hanna EY, Weber RS, El-Naggar AK. Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance . Mod Pathol 18:1-5, 2004. e-Pub 2004. PMID: 15492756.
Clark AL, Gillenwater A, Alizadeh-Naderi R, El-Naggar AK, Richards-Kortum R. Detection and diagnosis of oral neoplasia with an optical coherence microscope. J Biomed Opt 9:1271-1280, 2004. e-Pub 2004. PMID: 15568948.
Li G, Sturgis EM, Wang LE, Chamberlain RM, Amos CI, Spitz MR, El-Naggar AK, Hong WK, Wei Q. Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. Carcinogenesis 25:1911-1916, 2004. e-Pub 2004. PMID: 15180941.
Tai SK, Lee JI, Ang KK, El-Naggar AK, Hassan KA, Liu D, Lee JJ, Ren H, Hong WK, Mao L. Loss of Fhit expression in head and neck squamous cell carcinoma and its potential clinical implication. Clin Cancer Res 10:5554-5557, 2004. e-Pub 2004. PMID: 15328196.
Zhang Z, Shi Q, Wang LE, Sturgis EM, Spitz MR, El-Naggar AK, Hong WK, Wei Q. No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev 13:1081-1083, 2004. e-Pub 2004. PMID: 15184269.
Sudbo J, Lippman SM, Lee JJ, Mao L, Kildal W, Sudbo A, Sagen S, Bryne M, El-Naggar A, Risberg B, Evensen JF, Reith A. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 350:1405-1413, 2004. e-Pub 2004. PMID: 15070790.
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119:861-872, 2004. e-Pub 2004. PMID: 15607981.
Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM, Jr, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R. Parathyroid carcinoma: a 22-year experience. Head Neck 26:716-726, 2004. e-Pub 2004. PMID: 15287039.
Jimenez C, Dang GT, Schultz PN, El-Naggar AK, Shapiro S, Barnes EA, Evans DB, Vassilopoulou-Sellin R, Gagel RF, Cote GJ, Hoff AO. A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma. J Clin Endocrinol Metab 89:3521-3526, 2004. e-Pub 2004. PMID: 15240641.
Cohn ML, Callender DL, El-Naggar AK. Sebaceous carcinoma ex-pleomorphic adenoma: a rare phenotypic occurrence. Ann Diagn Pathol 8:224-226, 2004. e-Pub 2004. PMID: 15290674.
Moran CA, Suster S, El-Naggar AK, Luna MA. Carcinomas arising in multilocular thymic cysts of the neck: a clinicopathological study of three cases. Histopathology 44:64-68, 2004. e-Pub 2004. PMID: 14717671.
Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R. Vision enhancement system for detection of oral cavity neoplasia based on autofluorescence. Head Neck 26:205-215, 2004. e-Pub 2004. PMID: 14999795.
Wang L, Rodriguez M, Kim ES, Xu Y, Bekele N, El-Naggar AK, Hong WK, Mao L, Oh YW. A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer. Int J Oncol 25:993-999, 2004. e-Pub 2004. PMID: 15375549.
Choi HR, Roberts DB, Johnigan RH, Sturgis EM, Rosenthal DI, Weber RS, Luna MA, Batsakis JG, El-Naggar AK. Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: common and distinctive features of biological significance. Am J Surg Pathol 28:1299-1310, 2004. e-Pub 2004. PMID: 15371945.
Maruya S, Issa JP, Weber RS, Rosenthal DI, Haviland JC, Lotan R, El-Naggar AK. Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications. Clin Cancer Res 10:3825-3830, 2004. e-Pub 2004. PMID: 15173091.
Clayman GL, Gonzalez HE, El-Naggar A, Vassilopoulou-Sellin R. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer 100:900-905, 2004. e-Pub 2004. PMID: 14983483.
Barkan GA, El-Naggar AK. Primary synovial sarcoma of the parotid gland. Ann Diagn Pathol 8:233-236, 2004. e-Pub 2004. PMID: 15290676.
Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, Ioannides CG, Efferson CL, El-Naggar AK, Roberts D, Clayman GL, Frederick MJ. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res 64:8262-8270, 2004. e-Pub 2004. PMID: 15548693.
Chevillard S, Ugolin N, Vielh P, Ory K, Levalois C, Elliott D, Clayman GL, El-Naggar AK. Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications. Clin Cancer Res 10:6586-6597, 2004. e-Pub 2004. PMID: 15475448.
Curino A, Patel V, Nielsen BS, Iskander AJ, Ensley JF, Yoo GH, Holsinger C, Myers JN, El-Naggar AK, Kellman RM, Shillitoe EJ, Mollinolo AA, Gutkind JS, Bugge H. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. . Oral Oncology 40:1026-1032, 2004. e-Pub 2004.
Selek U, Garden AS, Morrison WH, El-Naggar AK, Rosenthal DI, Ang KK. Radiation therapy for early-stage carcinoma of the oropharynx. Int J Radiat Oncol Biol Phys 59:743-751, 2004. e-Pub 2004. PMID: 15183477.
El-Naggar AK, Vielh P. Solid tumor DNA content analysis. Methods Mol Biol 263:355-70, 2004. e-Pub 2004. PMID: 14976377.
Cohn ML, Elliott DD, El-Naggar AK. Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma. . Head Neck 24:76-80, 2004. e-Pub 2004. PMID: 15565563.
Yang Z, Bagheri-Yarmand R, Wang RA, Adam L, Papadimitrakopoulou VV, Clayman GL, El-Naggar AK, Lotan R, Barnes CJ, Hong WK, Kumar R. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Clin Cancer Res 10:658-667, 2004. e-Pub 2004. PMID: 14760089.
El-Naggar AK. Concurrent flow cytometric analysis of DNA and RNA. Methods Mol Biol 263:371-84, 2004. e-Pub 2004. PMID: 14976378.
Li G, Sturgis EM, Wang LE, Chamberlain RM, Spitz MR, El-Naggar AK, Hong WK, Wei Q. Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma. Clin Cancer Res 10:3996-4002, 2004. e-Pub 2004. PMID: 15217930.
Sabloff B, Munden RF, Melhem AI, El-Naggar AK, Putnam JB, Jr. Radiologic-pathologic conferences of the University of Texas M. D. Anderson Cancer Center: Extraskeletal osteosarcoma of the pleura. AJR Am J Roentgenol 180:972, 2003. e-Pub 2003. PMID: 12646438.
Rosenthal, Barker JL, El-Naggar AK, Glisson BS, Kies MS, Diaz EM, Clayman GL, Demonte F, Selek U, Morrison WM, Ang KK, AS: G. Sinonasal carcinoma with neuroendocrine differentiation: patterns of failure according to histologic phenotype. . Int J Radiat Oncol Biol Phys 57:S248-S249, 2003. e-Pub 2003.
Choi HR, Tucker SA, Huang Z, Gillenwater AM, Luna MA, Batsakis JG, El-Naggar AK. Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis. Int J Oncol 22:409-414, 2003. e-Pub 2003. PMID: 12527941.
Clark AL, Gillenwater AM, Collier TG, Alizadeh-Naderi R, El-Naggar AK, Richards-Kortum RR. Confocal microscopy for real-time detection of oral cavity neoplasia. Clin Cancer Res 9:4714-4721, 2003. e-Pub 2003. PMID: 14581341.
Barker JL, Jr, Glisson BS, Garden AS, El-Naggar AK, Morrison WH, Ang KK, Chao KS, Clayman G, Rosenthal DI. Management of nonsinonasal neuroendocrine carcinomas of the head and neck. Cancer 98:2322-2328, 2003. e-Pub 2003. PMID: 14635065.
Dahlstrom KR, Adler-Storthz K, Etzel CJ, Liu Z, Dillon L, El-Naggar AK, Spitz MR, Schiller JT, Wei Q, Sturgis EM. Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. Clin Cancer Res 9:2620-2626, 2003. e-Pub 2003. PMID: 12855639.
Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, Mitsudo K, Silverman GA, EL-Naggar AK, Bromme D, Clayman GL. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys 409:367-374, 2003. e-Pub 2003. PMID: 12504904.
Rudin CM, Cohen EE, Papadimitrakopoulou VA, Silverman S, Jr, Recant W, El-Naggar AK, Stenson K, Lippman SM, Hong WK, Vokes EE. An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia. J Clin Oncol 21:4546-4552, 2003. e-Pub 2003. PMID: 14597742.
Mitsudo K, Jayakumar A, Henderson Y, Frederick MJ, Kang Y, Wang M, El-Naggar AK, Clayman GL. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry 42:3874-3881, 2003. e-Pub 2003. PMID: 12667078.
Bolshakov S, Walker CM, Strom SS, Selvan MS, Clayman GL, El-Naggar AK, Lippman SM, Kripke ML, Ananthaswamy HN. p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. Clin Cancer Res 9:228-234, 2003. e-Pub 2003. PMID: 12538474.
Biddle DA, Evans HL, Kemp BL, El-Naggar AK, Harvell JD, White WL, Iskandar SS, Prieto VG. Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma. Am J Surg Pathol 27:673-681, 2003. e-Pub 2003. PMID: 12717252.
Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SY. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene 22:8902-8911, 2003. e-Pub 2003. PMID: 14654786.
Greenberg JS, El Naggar AK, Mo V, Roberts D, Myers JN. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Cancer 98:508-515, 2003. e-Pub 2003. PMID: 12879467.
Choi HR, Sturgis EM, Rosenthal DI, Luna MA, Batsakis JG, El-Naggar AK. Sarcomatoid carcinoma of the head and neck: molecular evidence for evolution and progression from conventional squamous cell carcinomas. Am J Surg Pathol 27:1216-1220, 2003. e-Pub 2003. PMID: 12960805.
Papadimitrakopoulou VA, Lui DD, Mao L, Shin DM, El-Naggar AK, Ibarguen H, Lee JJ, Hong WK, Hittelman WN. Biologic correlates of a biochemoprevention trail in advanced upper aerodigestive tract premalignant lesions. Cancer Epidemiol Biomarkers Prev 11:1605-1610, 2003. e-Pub 2003.
Swisher SG, Roth JA, Komaki R, Gu J, Lee JJ, Hicks NM, Ro JY, Hong WK, Merritt JA, Ahrar K, Alkinson NE, Correa AM, Dolormente M, Dreiling I, El-Naggar AK, Fossella F, Francisco R, Glisson B, Grammer S, Herbst R, Huaringa A, Kemp B, Khuri FR, Kurie JM, Liao Z, McDonnell TJ, Morice R, Morello F, Munden R, Papadimitrakopoulou V, Pisters KM, Jr PJ, Sarabia AJ, Shelton T, Stevens C, Shin DM, Smythe WR, Vaporciyan AA, Walsh GL, Yin M. p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. . Int J. Oncol 22:409-414, 2003. e-Pub 2003.
Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar AK, Griffin JD, Kirsch IR, Kaye FJ. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33:208-213, 2003. e-Pub 2003. PMID: 12539049.
MacGregor AR, Batsakis JG, El-Naggar AK. Myofibroblastoma of the larynx: a study of two cases. Head Neck 25:606-611, 2003. e-Pub 2003. PMID: 12808665.
Swisher SG, Roth JA, Komaki R, Gu J, Lee JJ, Hicks M, Ro JY, Hong WK, Merritt JA, Ahrar K, Atkinson NE, Correa AM, Dolormente M, Dreiling L, El-Naggar AK, Fossella F, Francisco R, Glisson B, Grammer S, Herbst R, Huaringa A, Kemp B, Khuri FR, Kurie JM, Liao Z, McDonnell TJ, Morice R, Morello F, Munden R, Papadimitrakopoulou V, Pisters KM, Putnam JB, Sarabia AJ, Shelton T, Stevens C, Shin DM, Smythe WR, Vaporciyan AA, Walsh GL, Yin M. Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res 9:93-101, 2003. e-Pub 2003. PMID: 12538456.
Caudell JJ, Ballo MT, Zagars GK, Lewis VO, Weber KL, Lin PP, Marco RA, El-Naggar AK, Benjamin RS, Yasko AW. Radiotherapy in the management of giant cell tumor of bone. Int J Radiat Oncol Biol Phys 57:158-165, 2003. e-Pub 2003. PMID: 12909228.
Greenberg JS, Fowler R, Gomez J, Mo V, Roberts D, El Naggar AK, Myers JN. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 97:1464-1470, 2003. e-Pub 2003. PMID: 12627511.
Choi HR, Sturgis EM, Rashid A, DeMonte F, Luna MA, Batsakis JG, El-Naggar AK. Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes. Hum Pathol 34:1101-1107, 2003. e-Pub 2003. PMID: 14652810.
Izzo JG, Papadimitrakopoulou VA, Liu DD, den Hollander PL, Babenko IM, Keck J, El-Naggar AK, Shin DM, Lee JJ, Hong WK, Hittelman WN. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. J Natl Cancer Inst 95:198-205, 2003. e-Pub 2003. PMID: 12569141.
Choi HR, Batsakis JG, Callender DL, Prieto VG, Luna MA, El-Naggar AK. Molecular analysis of chromosome 16q regions in dermal analogue tumors of salivary glands: a genetic link to dermal cylindroma?. Am J Surg Pathol 26:778-783, 2002. e-Pub 2002. PMID: 12023583.
Chang YS, Kong G, Sun S, Liu D, El-Naggar AK, Khuri FR, Hong WK, Lee HY. Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer. Clin Cancer Res 8:3796-3802, 2002. e-Pub 2002. PMID: 12473592.
Clifford JL, Walch E, Yang X, Xu X, Alberts DS, Clayman GL, El-Naggar AK, Lotan R, Lippman SM. Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis. Clin Cancer Res 8:2067-2072, 2002. e-Pub 2002. PMID: 12114405.
Hassan KA, Ang KK, El-Naggar AK, Story MD, Lee JI, Liu D, Hong WK, Mao L. Cyclin B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma. Cancer Res 62:6414-6417, 2002. e-Pub 2002. PMID: 12438226.
Choi HR, Batsakis JG, Zhan F, Sturgis E, Luna MA, El-Naggar AK. Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. Hum Pathol 33:158-164, 2002. e-Pub 2002. PMID: 11957139.
Lott ST, Chandler DS, Curley SA, Foster CJ, El-Naggar AK, Frazier M, Strong LC, Lovell M, Killary AM. High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. Cancer Res 62:1952-1955, 2002. e-Pub 2002. PMID: 11929809.
Frierson HF, Jr, El-Naggar AK, Welsh JB, Sapinoso LM, Su AI, Cheng J, Saku T, Moskaluk CA, Hampton GM. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol 161:1315-1323, 2002. e-Pub 2002. PMID: 12368205.
El-Naggar AK, Kim HW, Clayman GL, Coombes MM, Le B, Lai S, Zhan F, Luna MA, Hong WK, Lee JJ. Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classification. Oncogene 21:8206-8219, 2002. e-Pub 2002. PMID: 12444558.
Berrak SG, Ozek MM, Canpolat C, Dagcinar A, Sav A, El-Naggar AK, Langford LA. Association between DNA content and tumor suppressor gene expression and aggressiveness of atypical teratoid/rhabdoid tumors. Childs Nerv Syst 18:485-491, 2002. e-Pub 2002. PMID: 12382173.
Little DJ, Ballo MT, Zagars GK, Pisters PW, Patel SR, El-Naggar AK, Garden AS, Benjamin RS. Adult rhabdomyosarcoma: outcome following multimodality treatment. Cancer 95:377-388, 2002. e-Pub 2002. PMID: 12124838.
Shmulevich I, Hunt K, El-Naggar AK, Taylor E, Ramdas L, Laborde P, Hess KR, Pollock R, Zhang W. Tumor specific gene expression profiles in human leiomyosarcoma: an evaluation of intratumor heterogeneity. Cancer 94:2069-2075, 2002. e-Pub 2002. PMID: 11932911.
Sweeney P, El-Naggar AK, Lin SH, Pisters LL. Biological significance of c-met over expression in papillary renal cell carcinoma. J Urol 168:51-55, 2002. e-Pub 2002. PMID: 12050491.
Lee JI, Soria JC, Hassan KA, El-Naggar AK, Tang X, Liu DD, Hong WK, Mao L. Loss of PTEN expression as a prognostic marker for tongue cancer. Arch Otolaryngol Head Neck Surg 127:1441-1445, 2001. e-Pub 2001. PMID: 11735811.
Slaton JW, Inoue K, Perrotte P, El-Naggar AK, Swanson DA, Fidler IJ, Dinney CP. Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol 158:735-743, 2001. e-Pub 2001. PMID: 11159211.
Lee JI, Soria JC, Hassan K, Liu D, Tang X, El-Naggar AK, Hong WK, Mao L. Loss of Fhit expression is a predictor of poor outcome in tongue cancer. Cancer Res 61:837-841, 2001. e-Pub 2001. PMID: 11221865.
Klijanienko J, Lagace R, Servois V, Lussier C, El-Naggar AK, Vielh P. Fine-needle sampling of primary neuroendocrine carcinomas of salivary glands: cytohistological correlations and clinical analysis. Diagn Cytopathol 24:163-166, 2001. e-Pub 2001. PMID: 11241898.
Tseng JE, Glisson BS, Khuri FR, Shin DM, Myers JN, El-Naggar AK, Roach JS, Ginsberg LE, Thall PF, Wang X, Teddy S, Lawhorn KN, Zentgraf RE, Steinhaus GD, Pluda JM, Abbruzzese JL, Hong WK, Herbst RS. Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck. Cancer 92:2364-2373, 2001. e-Pub 2001. PMID: 11745292.
Hassan KA, El-Naggar AK, Soria JC, Liu D, Hong WK, Mao L. Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue. Clin Cancer Res 7:2458-2462, 2001. e-Pub 2001. PMID: 11489826.
El-Naggar AK, Lai S, Clayman GL, Mims B, Lippman SM, Coombes M, Luna MA, Lozano G. p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas. Carcinogenesis 22:729-735, 2001. e-Pub 2001. PMID: 11323391.
Evans SC, Viswanathan M, Grier JD, Narayana M, El-Naggar AK, Lozano G. An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene 20:4041-4049, 2001. e-Pub 2001. PMID: 11494132.
Jiang W, Ananthaswamy HN, Muller HK, Ouhtit A, Bolshakov S, Ullrich SE, El-Naggar AK, Kripke ML. UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53. Proc Natl Acad Sci U S A 98:9790-9795, 2001. e-Pub 2001. PMID: 11481437.
Papadimitrakopoulou VA, Izzo J, Mao L, Keck J, Hamilton D, Shin DM, El-Naggar AK, den Hollander P, Liu D, Hittelman WN, Hong WK. Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development. Clin Cancer Res 7:3127-3134, 2001. e-Pub 2001. PMID: 11595705.
Pachmann K, Zhao S, Schenk T, Kantarjian H, El-Naggar AK, Siciliano MJ, Guo JQ, Arlinghaus RB, Andreeff M. Expression of bcr-abl mRNA in individual chronic myelogenous leukaemia cells as determined by in situ amplification. Br J Haematol 112:749-759, 2001. e-Pub 2001. PMID: 11260080.
Kim J, Shin DM, El-Naggar AK, Lee JS, Corrales C, Lippman SM, Hong WK, Hittelman WN. Chromosome polysomy and histological characteristics in oral premalignant lesions. Cancer Epidemiol Biomarkers Prev 10:319-325, 2001. e-Pub 2001. PMID: 11319171.
Reles A, Wen WH, Schmider A, Gee C, Runnebaum IB, Kilian U, Jones LA, El-Naggar AK, Minguillon C, Schonborn I, Reich O, Kreienberg R, Lichtenegger W, Press MF. Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer. Clin Cancer Res 7:2984-2997, 2001. e-Pub 2001. PMID: 11595686.
El-Naggar AK, Mao L, Staerkel G, Coombes MM, Tucker SL, Luna MA, Clayman GL, Lippman S, Goepfert H. Genetic heterogeneity in saliva from patients with oral squamous carcinomas: implications in molecular diagnosis and screening. J Mol Diagn 3:164-170, 2001. e-Pub 2001. PMID: 11687600.
Hoang MP, Callender DL, Sola Gallego JJ, Huang Z, Sneige N, Luna MA, Batsakis JG, El-Naggar AK. Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma. Int J Oncol 19:865-871, 2001. e-Pub 2001. PMID: 11562768.
Maciorowski Z, Klijanienko J, Padoy E, Mosseri V, Fourquet A, Chevillard S, El-Naggar AK, Vielh P. Comparative image and flow cytometric TUNEL analysis of fine needle samples of breast carcinoma. Cytometry 46:150-156, 2001. e-Pub 2001. PMID: 11449405.
Spring PM, Myers JN, El-Naggar AK, Langstein HN. Malignant melanoma arising within a burn scar case report and review of the literature. Ann Otol Rhinol Laryngol 110:369-376, 2001. e-Pub 2001. PMID: 11307915.
Lai S, Goepfert H, Gillenwater AM, Luna MA, El-Naggar AK. Loss of imprinting and genetic alterations of the cyclin-dependent kinase inhibitor p57KIP2 gene in head and neck squamous cell carcinoma. Clin Cancer Res 6:3172-3176, 2000. e-Pub 2000. PMID: 10955800.
Audebert M, Chevillard S, Levalois C, Gyapay G, Vieillefond A, Klijanienko J, Vielh P, El Naggar AK, Oudard S, Boiteux S, Radicella JP. Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney. Cancer Res 60:4740-4744, 2000. e-Pub 2000. PMID: 10987279.
Lee JJ, Hong WK, Hittelman WN, Mao L, Lotan R, Shin DM, Benner SE, Xu XC, Lee JS, Papadimitrakopoulou VM, Geyer C, Perez C, Martin JW, El-Naggar AK, Lippman SM. Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res 6:1702-1710, 2000. e-Pub 2000. PMID: 10815888.
Yen N, Ioannides CG, Xu K, Swisher SG, Lawrence DD, Kemp BL, El-Naggar AK, Cristiano RJ, Fang B, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Merritt JA, Mukhopadhyay T, Nesbitt JC, Nguyen D, Perez-Soler R, Pisters KM, Putnam JB, Jr, Schrump DS, Shin DM, Walsh GL, Roth JA. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type. P53 (Ad-p53). Cancer Gene Ther 7:530-536, 2000. e-Pub 2000. PMID: 10811470.
Tae K, El-Naggar AK, Yoo E, Feng L, Lee JJ, Hong WK, Hittelman WN, Shin DM. Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. Clin Cancer Res 6:2821-2828, 2000. e-Pub 2000. PMID: 10914730.
Liu G, McDonnell TJ, Montes de Oca Luna R, Kapoor M, Mims B, El-Naggar AK, Lozano G. High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A 97:4174-4179, 2000. e-Pub 2000. PMID: 10760284.
Xu XC, Sola Gallego JJ, Lotan R, El-Naggar AK. Differential expression of galectin-1 and galectin-3 in benign and malignant salivary gland neoplasms. Int J Oncol 17:271-276, 2000. e-Pub 2000. PMID: 10891535.
Frederick MJ, Henderson Y, Xu X, Deavers MT, Sahin AA, Wu H, Lewis DE, El-Naggar AK, Clayman GL. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am J Pathol 156:1937-1950, 2000. e-Pub 2000. PMID: 10854217.
Suarez PA, Adler-Storthz K, Luna MA, El-Naggar AK, Abdul-Karim FW, Batsakis JG. Papillary squamous cell carcinomas of the upper aerodigestive tract: a clinicopathologic and molecular study. Head Neck 22:360-368, 2000. e-Pub 2000. PMID: 10862019.
Clifford JL, Menter DG, Yang X, Walch E, Zou C, Clayman GL, Schaefer TS, El-Naggar AK, Lotan R, Lippman SM. Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev 9:993-997, 2000. e-Pub 2000. PMID: 11008921.
WY-K L, C-T HU, Li L, Johnston DA, S-J S, El-Naggar AK, M-C: H. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. . Oncogene 19:2398-2403, 2000. e-Pub 2000.
Shin DM, Mao L, Papadimitrakopoulou VM, Clayman G, El-Naggar AK, Shin HJ, Lee JJ, Lee JS, Gillenwater A, Myers J, Lippman SM, Hittelman WN, Hong WK. Biochemopreventive therapy for patients with premalignant lesions of the head and neck and p53 gene expression. J Natl Cancer Inst 92:69-73, 2000. e-Pub 2000. PMID: 10620636.
Dano L, Guilly MN, Muleris M, Morlier JP, Altmeyer S, Vielh P, El-Naggar AK, Monchaux G, Dutrillaux B, Chevillard S. CGH analysis of radon-induced rat lung tumors indicates similarities with human lung cancers. Genes Chromosomes Cancer 29:1-8, 2000. e-Pub 2000. PMID: 10918387.
Sorensen DM, Gokden M, El-Naggar AK, Byers RM. Quiz case 1. Periosteal osteosarcoma (PO) of the mandible. Arch Otolaryngol Head Neck Surg 126:550-552, 2000. e-Pub 2000. PMID: 10772315.
Milas M, Yu D, Lang A, Ge T, Feig B, El-Naggar AK, Pollock RE. Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity. Cancer Gene Ther 7:422-429, 2000. e-Pub 2000. PMID: 10766348.
El-Naggar AK, Callender D, Coombes MM, Hurr K, Luna MA, Batsakis JG. Molecular genetic alterations in carcinoma ex-pleomorphic adenoma: a putative progression model?. Genes Chromosomes Cancer 27:162-168, 2000. e-Pub 2000. PMID: 10612804.
Barnett CC, Jr, Varma DG, El-Naggar AK, Dackiw AP, Porter GA, Pearson AS, Kudelka AP, Gagel RF, Evans DB, Lee JE. Limitations of size as a criterion in the evaluation of adrenal tumors. Surgery 128:973-982, 2000. e-Pub 2000. PMID: 11114632.
Maciorowski Z, Klijanienko J, Padoy E, Mosseri V, Dieras V, El-Naggar AK, Chevillard S, Vielh P. Differential expression of Bax and Bcl-2 in the assessment of cellular dynamics in fine-needle samples of primary breast carcinomas. Cytometry 42:264-269, 2000. e-Pub 2000. PMID: 11025483.
el-Naggar AK. Diagnostic molecular pathology comes of age. Adv Anat Pathol 6(6):324-6, 1999. e-Pub 1999. PMID: 10562894.
Batsakis JG, el-Naggar AK. Myoepithelium in salivary and mammary neoplasms is host-friendly. Adv Anat Pathol 6(4):218-26, 1999. e-Pub 1999. PMID: 10410175.
Lovell M, Lott ST, Wong P, El-Naggar AK, Tucker S, Killary AM. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Res 59:2182-2189, 1999. e-Pub 1999. PMID: 10232606.
Delehedde M, Cho SH, Sarkiss M, Brisbay S, Davies M, El-Naggar AK, McDonnell TJ. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer. Cancer 85:1514-1522, 1999. e-Pub 1999. PMID: 10193941.
Liu TJ, Wang M, Breau RL, Henderson Y, El-Naggar AK, Steck KD, Sicard MW, Clayman GL. Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines. Cancer Gene Ther 6:163-171, 1999. e-Pub 1999. PMID: 10195883.
Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC. Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis. Am J Pathol 155:1519-1523, 1999. e-Pub 1999. PMID: 10550308.
El-Naggar AK, Dinh M, Tucker SL, Swanson D, Steck K, Vielh P. Numerical chromosomal changes in DNA hypodiploid solid tumors: restricted loss and gain of certain chromosomes. Cytometry 37:107-112, 1999. e-Pub 1999. PMID: 10486522.
El-Naggar AK, Lai S, Clayman GL, Zhou JH, Tucker SA, Myers J, Luna MA, Benedict WF. Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications. Hum Pathol 30:1013-1018, 1999. e-Pub 1999. PMID: 10492034.
Papadimitrakopoulou VA, Clayman GL, Shin DM, Myers JN, Gillenwater AM, Goepfert H, El-Naggar AK, Lewin JS, Lippman SM, Hong WK. Biochemoprevention for dysplastic lesions of the upper aerodigestive tract. Arch Otolaryngol Head Neck Surg 125:1083-1089, 1999. e-Pub 1999. PMID: 10522499.
El-Naggar AK, Lai S, Tucker SA, Clayman GL, Goepfert H, Hong WK, Huff V. Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma. Oncogene 18:7063-7069, 1999. e-Pub 1999. PMID: 10597307.
Klijanienko J, El-Naggar AK, Vielh P. Comparative cytologic and histologic study of fifteen salivary basal-cell tumors: differential diagnostic considerations. Diagn Cytopathol 21:30-34, 1999. e-Pub 1999. PMID: 10405805.
Jin YT, Myers J, Tsai ST, Goepfert H, Batsakis JG, El-Naggar AK. Genetic alterations in oral squamous cell carcinoma of young adults. Oral Oncol 35:251-256, 1999. e-Pub 1999. PMID: 10621844.
Steck K, Hunt K, Tucker S, Singletary S, El-Naggar AK. Flow cytometric analysis of Ki-67 in invasive ductal carcinoma of the breast: correlation with tumor and patient characteristics. Oncol Rep 6:835-838, 1999. e-Pub 1999. PMID: 10373666.
El-Naggar AK, Lovell M, Callender DL, Ordonez NG, Killary AM. Cytogenetic analysis of a primary salivary gland myoepithelioma. Cancer Genet Cytogenet 113:49-53, 1999. e-Pub 1999. PMID: 10459346.
Lai S, El-Naggar AK. Differential expression of key cell cycle genes (p16/cyclin D1/pRb) in head and neck squamous carcinomas. Lab Invest 79:255-260, 1999. e-Pub 1999. PMID: 10092061.
Klijanienko J, Couturier J, Galut M, El-Naggar AK, Maciorowski Z, Padoy E, Mosseri V, Vielh P. Detection and quantitation by fluorescence in situ hybridization (FISH) and image analysis of HER-2/neu gene amplification in breast cancer fine-needle samples. Cancer 87:312-318, 1999. e-Pub 1999. PMID: 10536358.
Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AK, Ayala AG. Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 12:1034-1042, 1999. e-Pub 1999. PMID: 10574600.
Swisher SG, Roth JA, Nemunaitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mack M, Merritt JA, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Jr, Richli WR, Savin M, Schrump DS, Shin DM, Shulkin A, Walsh GL, Wait J, Weill D, Waugh MK. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst 91:763-771, 1999. e-Pub 1999. PMID: 10328106.
Fordice J, Kershaw C, El-Naggar AK, Goepfert H. Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg 125:149-152, 1999. e-Pub 1999. PMID: 10037280.
Wen WH, Reles A, Runnebaum IB, Sullivan-Halley J, Bernstein L, Jones LA, Felix JC, Kreienberg R, El-Naggar AK, Press MF. p53 mutations and expression in ovarian cancers: correlation with overall survival. Int J Gynecol Pathol 18:29-41, 1999. e-Pub 1999. PMID: 9891239.
Evans SC, Foster CJ, El-Naggar AK, Lozano G. Mapping and mutational analysis of the human TAF2G gene encoding a p53 cofactor. Genomics 57:182-183, 1999. e-Pub 1999. PMID: 10191103.
El-Naggar AK, Lovell M, Callender DL, Killary AM. Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland. Cancer Genet Cytogenet 109:66-69, 1999. e-Pub 1999. PMID: 9973962.
Klijanienko J, El-Naggar AK, Vielh P. Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas: diagnostic pitfalls and clinical considerations. Diagn Cytopathol 21:163-166, 1999. e-Pub 1999. PMID: 10450099.
Klijanienko J, El-Naggar AK, Servois V, Rodriguez J, Desjardins L, Schlienger P, Validire P, Vielh P. Histologically similar, synchronous or metachronous, lacrimal salivary-type and parotid gland tumors: A series of 11 cases. Head Neck 21:512-516, 1999. e-Pub 1999. PMID: 10449666.
Klijanienko J, Servois V, Jammet P, Validire P, Pouillart P, Vielh P, El-Naggar AK, Dulmet E. Pleomorphic adenoma. Am J Surg Pathol 22(6):772-3, 1998. e-Pub 1998. PMID: 9630186.
Byers RM, El-Naggar AK, Lee YY, Rao B, Fornage B, Terry NH, Sample D, Hankins P, Smith TL, Wolf PJ. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?. Head Neck 20(2):138-44, 1998. e-Pub 1998. PMID: 9484945.
Roth JA, Swisher SG, Merritt JA, Lawrence DD, Kemp BL, Carrasco CH, El-Naggar AK, Fossella FV, Glisson BS, Hong WK, Khurl FR, Kurie JM, Nesbitt JC, Pisters K, Putnam JB, Schrump DS, Shin DM, Walsh GL. Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement. Semin Oncol 25:33-37, 1998. e-Pub 1998. PMID: 9704675.
Coombes MM, Mao L, Steck KD, Luna MA, El-Naggar AK. Genotypic analysis of flow-sorted and microdissected head and neck squamous lesions by whole-genome amplification. Diagn Mol Pathol 7:197-201, 1998. e-Pub 1998. PMID: 9917129.
El-Naggar AK, Abdul-Karim FW, Hurr K, Callender D, Luna MA, Batsakis JG. Genetic alterations in acinic cell carcinoma of the parotid gland determined by microsatellite analysis. Cancer Genet Cytogenet 102:19-24, 1998. e-Pub 1998. PMID: 9530335.
Papadimitrakopoulou VA, Oh Y, El-Naggar AK, Izzo J, Clayman G, Mao L. Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer. Clin Cancer Res 4:539-544, 1998. e-Pub 1998. PMID: 9533520.
Woods KV, El-Naggar AK, Clayman GL, Grimm EA. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res 58:3132-3141, 1998. e-Pub 1998. PMID: 9679981.
Klijanienko J, El-Naggar AK, Servois V, Rodriguez J, Validire P, Vielh P. Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. Cancer 84:231-234, 1998. e-Pub 1998. PMID: 9723598.
Byers RM, El-Naggar AK, Y-Y L, Rao B, Fornage B, Terry NHA, Sample D, Hankins P, Smith TL, Wolf PJ. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?. Head and Neck 20:138-144, 1998. e-Pub 1998.
El-Naggar AK, Coombes MM, Batsakis JG, Hong WK, Goepfert H, Kagan J. Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma. Oncogene 16:2983-2987, 1998. e-Pub 1998. PMID: 9662330.
Yao J, Pollock RE, Lang A, Tan M, Pisters PW, Goodrich D, El-Naggar AK, Yu D. Infrequent mutation of the p16/MTS1 gene and overexpression of cyclin-dependent kinase 4 in human primary soft-tissue sarcoma. Clin Cancer Res 4:1065-1070, 1998. e-Pub 1998. PMID: 9563903.
Gillenwater A, Jacob R, Ganeshappa R, Kemp B, El-Naggar AK, Palmer JL, Clayman G, Mitchell MF, Richards-Kortum R. Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence. Arch Otolaryngol Head Neck Surg 124:1251-1258, 1998. e-Pub 1998. PMID: 9821929.
Izzo JG, Papadimitrakopoulou VA, Li XQ, Ibarguen H, Lee JS, Ro JY, El-Naggar AK, Hong WK, Hittelman WN. Dysregulated cyclin D1 expression early in head and neck tumorigenesis: in vivo evidence for an association with subsequent gene amplification. Oncogene 17:2313-2322, 1998. e-Pub 1998. PMID: 9811462.
Roberts HL, Komaki R, Allen P, El-Naggar AK. Prognostic significance of DNA content in stage I adenocarcinoma of the lung. Int J Radiat Oncol Biol Phys 41:573-578, 1998. e-Pub 1998. PMID: 9635704.
Dubey P, Ha CS, Ang KK, El-Naggar AK, Knapp C, Byers RM, Morrison WH. Nonnasopharyngeal lymphoepithelioma of the head and neck. Cancer 82:1556-1562, 1998. e-Pub 1998. PMID: 9554534.
Clayman GL, El-Naggar AK, Lippman SM, Henderson YC, Frederick M, Merritt JA, Zumstein LA, Timmons TM, Liu TJ, Ginsberg L, Roth JA, Hong WK, Bruso P, Goepfert H. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 16:2221-2232, 1998. e-Pub 1998. PMID: 9626224.
El-Naggar AK, Lovell M, Ordonez NG, Killary AM. Multiple unrelated translocations in a metastatic epimyoepithelial carcinoma of the parotid gland. Cancer Genet Cytogenet 100:155-158, 1998. e-Pub 1998. PMID: 9428361.
Mao L, El-Naggar AK, Papadimitrakopoulou V, Shin DM, Shin HC, Fan Y, Zhou X, Clayman G, Lee JJ, Lee JS, Hittelman WN, Lippman SM, Hong WK. Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy. J Natl Cancer Inst 90:1545-1551, 1998. e-Pub 1998. PMID: 9790547.
Ballo MT, Garden AS, El-Naggar AK, Gillenwater AM, Morrison WH, Goepfert H, Ang KK. Radiation therapy for early stage (T1-T2) sarcomatoid carcinoma of true vocal cords: outcomes and patterns of failure. Laryngoscope 108:760-763, 1998. e-Pub 1998. PMID: 9591559.
Jin YT, Kayser S, Kemp BL, Ordonez NG, Tucker SL, Clayman GL, Goepfert H, Luna MA, Batsakis JG, El-Naggar AK. The prognostic significance of the biomarkers p21WAF1/CIP1, p53, and bcl-2 in laryngeal squamous cell carcinoma. Cancer 82:2159-2165, 1998. e-Pub 1998. PMID: 9610695.
El-Naggar AK, Dinh M, Tucker SL, Gillenwater A, Luna MA, Batsakis JG. Chromosomal and DNA ploidy characterization of salivary gland neoplasms by combined FISH and flow cytometry. Hum Pathol 28(8):881-6, 1997. e-Pub 1997. PMID: 9269822.
Suarez P, el-Naggar AK, Batsakis JG. Intracellular crystalline deposits in lymphoplasmacellular disorders. Ann Otol Rhinol Laryngol 106(2):170-2, 1997. e-Pub 1997. PMID: 9041825.
Lai S, Benedict WF, Silver SA, El-Naggar AK. Loss of retinoblastoma gene function and heterozygosity at the RB locus in renal cortical neoplasms. Hum Pathol 28:693-697, 1997. e-Pub 1997. PMID: 9191003.
Cagle PT, El-Naggar AK, Xu HJ, Hu SX, Benedict WF. Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications. Am J Pathol 150:393-400, 1997. e-Pub 1997. PMID: 9033254.
Silva EG, Tornos C, Fritsche HA, Jr, El-Naggar AK, Gray K, Ordonez NG, Luna M, Gershenson D. The induction of benign epithelial neoplasms of the ovaries of guinea pigs by testosterone stimulation: a potential animal model. Mod Pathol 10:879-883, 1997. e-Pub 1997. PMID: 9310950.
Pershouse MA, El-Naggar AK, Hurr K, Lin H, Yung WK, Steck PA. Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma. Oncogene 14:369-373, 1997. e-Pub 1997. PMID: 9018123.
Clayman G, El-Naggar AK Merritt J, Bruso P, Roth JA, Lippman S, Hong WK, Goepfert H. Adenovirus-Mediated p53 Gene Transfer in a Phase I Trial of Patients with Advanced Recurrent Head and Neck Squamous Cell Carcinoma. . Proc Annu Meet Am Soc Clin Oncol 16:A1363, 1997. e-Pub 1997.
Overholt SM, Liu TJ, Taylor DL, Wang M, El-Naggar AK, Shillitoe E, Adler-Storthz K, John LS, Zhang WW, Roth JA, Clayman GL. Head and neck squamous cell growth suppression using adenovirus-p53-FLAG: a potential marker for gene therapy trials. Clin Cancer Res 3:185-191, 1997. e-Pub 1997. PMID: 9815671.
El-Naggar AK, Hurr K, Kagan J, Gillenwater A, Callender D, Luna MA, Batsakis JG. Genotypic alterations in benign and malignant salivary gland tumors: histogenetic and clinical implications. Am J Surg Pathol 21:691-697, 1997. e-Pub 1997. PMID: 9199647.
El-Naggar AK, Hurr K, Luna MA, Goepfert H, Hong WK, Batsakis JG. Intratumoral genetic heterogeneity in primary head and neck squamous carcinoma using microsatellite markers. Diagn Mol Pathol 6:305-308, 1997. e-Pub 1997. PMID: 9559289.
Gillenwater A, Hurr K, Wolf P, Batsakis JG, Goepfert H, El-Naggar AK. Microsatellite alterations at chromosome 8q loci in pleomorphic adenoma. Otolaryngol Head Neck Surg 117:448-452, 1997. e-Pub 1997. PMID: 9374165.
Pisters LL, El-Naggar AK, Luo W, Malpica A, Lin SH. C-met proto-oncogene expression in benign and malignant human renal tissues. J Urol 158:724-872, 1997. e-Pub 1997. PMID: 9258068.
Klijanienko J, El-Naggar AK, Servois V, Rodriguez J, Validire P, Vielh P. Clinically aggressive metastasizing pleomorphic adenoma: report of two cases. Head Neck 19:629-633, 1997. e-Pub 1997. PMID: 9323153.
Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC. Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms. Sarcoma 1(1):23-9, 1997. e-Pub 1997. PMID: 18521197.
El-Naggar AK, Lai S, Clayman G, Lee JK, Luna MA, Goepfert H, Batsakis JG. Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. Am J Pathol 151:1767-1774, 1997. e-Pub 1997. PMID: 9403727.
Klijanienko, Servois V, Jammet P, Validire P, Pouillart P, Vielh P, El-Naggar AK, E: D. Letter to the Editor: Pleomorphic Adenoma. . AM J Surg Pathol 21:13-22, 1997. e-Pub 1997.
Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC. Enchanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms. . Sarcoma 1:23-29, 1997. e-Pub 1997.
Eissa S, Wahed MA, Ismail A, Amer K, Khalifa, El-Naggar AK. DNA ploidy in Hepatic Cirrhosis, Dysplasia and Carcinoma: Evidence of Clonal Progression. . Oncology Reports 4:441-445, 1997. e-Pub 1997.
Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar AK, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 57:5221-5225, 1997. e-Pub 1997. PMID: 9393738.
Gershenson DM, Baker VV, Price JE, Hung MC, El-Naggar AK, Tortolero-Luna G, Silva EG. Molecular profile of advanced-stage transitional cell carcinoma of the ovary. Am J Obstet Gynecol 177:120-125, 1997. e-Pub 1997. PMID: 9240594.
Press MF, Bernstein L, Thomas PA, Meisner LF, Zhou JY, Ma Y, Hung G, Robinson RA, Harris C, El-Naggar AK, Slamon DJ, Phillips RN, Ross JS, Wolman SR, Flom KJ. HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas. J Clin Oncol 15:2894-2904, 1997. e-Pub 1997. PMID: 9256133.
Garden AS, El-Naggar AK, Morrison WH, Callender DL, Ang KK, Peters LJ. Postoperative radiotherapy for malignant tumors of the parotid gland. Int J Radiat Oncol Biol Phys 37:79-85, 1997. e-Pub 1997. PMID: 9054880.
Eicher SA, Overholt SM, el-Naggar AK, Byers RM, Weber RS. Lower gingival carcinoma. Clinical and pathologic determinants of regional metastases. Arch Otolaryngol Head Neck Surg 122(6):634-8, 1996. e-Pub 1996. PMID: 8639295.
Austin JR, Cebrun H, Kershisnik MM, El-Naggar AK, Garden AS, Demonte F, Ginsberg LE, Lippman SM, Goepfert H. Olfactory neuroblastoma and neuroendocrine carcinoma of the anterior skull base: treatment results at the m.d. Anderson cancer center. Skull Base Surg 6(1):1-8, 1996. e-Pub 1996. PMID: 17170947.
Linden MD, El-Naggar AK, Nathanson SD, Jacobson G, Zarbo RJ. Lack of correlation between flow cytometric and immunohistologic proliferation measurements of tumors. Mod Pathol 6:682-689, 1996. e-Pub 1996. PMID: 8782208.
Gillenwater A, Xu XC, El-Naggar AK, Clayman GL, Lotan R. Expression of galectins in head and neck squamous cell carcinoma. Head Neck 18:422-432, 1996. e-Pub 1996. PMID: 8864733.
Felix A, El-Naggar AK, Press MF, Ordonez NG, Fonseca I, Tucker SL, Luna MA, Batsakis JG. Prognostic significance of biomarkers (c-erbB-2, p53, proliferating cell nuclear antigen, and DNA content) in salivary duct carcinoma. Hum Pathol 27:561-566, 1996. e-Pub 1996. PMID: 8666365.
El-Naggar AK, Luna MA, Goepfert H, Batsakis JG. Molecular and immunohistochemical analysis of the p53 gene in head and neck squamous tumorigenesis. . Head and Neck Cancer - Advances in Basic Research:297-306, 1996. e-Pub 1996.
Sneige N, Sahin A, Dinh M, El-Naggar AK. Interphase cytogenetics in mammographically detected breast lesions. Hum Pathol 27:330-335, 1996. e-Pub 1996. PMID: 8617474.
Pollock RE, Lang A, Luo J, El-Naggar AK, Yu D. Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells. Oncogene 12:2035-2039, 1996. e-Pub 1996. PMID: 8649865.
Fuhrman GM, Leach SD, Staley CA, Cusack JC, Charnsangavej C, Cleary KR, El-Naggar AK, Fenoglio CJ, Lee JE, Evans DB. Rationale for en bloc vein resection in the treatment of pancreatic adenocarcinoma adherent to the superior mesenteric-portal vein confluence. Pancreatic Tumor Study Group. Ann Surg 223:154-162, 1996. e-Pub 1996. PMID: 8597509.
Sastry KJ, Marin MC, Nehete PN, McConnell K, El-Naggar AK, McDonnell TJ. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene 13:487-493, 1996. e-Pub 1996. PMID: 8760290.
Wang RY, Troncoso P, Palmer JL, El-Naggar AK, Liang JC. Trisomy 7 by dual-color fluorescence in situ hybridization: a potential biological marker for prostate cancer progression. Clin Cancer Res 2:1553-1558, 1996. e-Pub 1996. PMID: 9816332.
El-Naggar AK, Kemp BL, Sneige N, Hurr KG, Steck K, Tu ZN, Fritsche HA, Singletary SE, Balch CM. Bivariate RNA and DNA content analysis in breast carcinoma: biological significance of RNA content. Clin Cancer Res 2:419-426, 1996. e-Pub 1996. PMID: 9816186.
Ling YH, El-Naggar AK, Priebe W, Perez-Soler R. Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells. Mol Pharmacol 49:832-841, 1996. e-Pub 1996. PMID: 8622633.
Sarkiss M, Hsu B, El-Naggar AK, McDonnell TJ. The clinical relevance of assessment of apoptotic cell death. Advances in Anatomic Pathology 4:205-211, 1996. e-Pub 1996.
El-Naggar AK, Dinh M, Tucker S, Luna MA, Goepfert H, Hsu P, Batsakis JG. Genotypic analysis of primary head and neck squamous carcinoma by combined fluorescence in situ hybridization and DNA flow cytometry. Am J Clin Pathol 105:102-8, 1996. e-Pub 1996. PMID: 8561074.
Austin JR, Cebrun H, Kershisnik MM, El-Naggar AK, Garden AS, DeMonte F, Ginsberg LE, Lippman SM, H: G. Olfactory neuroblastoma and neuroendocrine carcinoma of the anterior skull base: Treatment results at the M.D. Anderson Cancer Center. . Skull Base Surgery 6:1-8, 1996. e-Pub 1996.
El-Naggar AK, Goepfert H, JG: B. Molecular genetic analysis of head and neck squamous tumorigenesis by microsatellite markers. . Head and Neck Cancer - Advances in Basic Research:169-177, 1996. e-Pub 1996.
Voytek TM, Ro JY, El-Naggar AK, Ordonez NG, Tornos C, Welch GR, Ayala AG. Metastatic ovarian granulosa cell tumor to urinary bladder mimicking primary transitional cell carcinoma. . Int J Urol 4:57-67, 1996. e-Pub 1996.
Hurr K, Kemp B, Silver SA, El-Naggar AK. Microsatellite alteration at chromosome 3p loci in neuroendocrine and non-neuroendocrine lung tumors. Histogenetic and clinical relevance. Am J Pathol 149:613-620, 1996. e-Pub 1996. PMID: 8701999.
Mao L, El-Naggar AK, Fan YH, Lee JS, Lippman SM, Kayser S, Lotan R, Hong WK. Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues. Cancer Res 56:5600-5604, 1996. e-Pub 1996. PMID: 8971162.
Janot F, Klijanienko J, Russo A, Mamet JP, de Braud F, El-Naggar AK, Pignon JP, Luboinski B, Cvitkovic E. Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis. Br J Cancer 73:531-538, 1996. e-Pub 1996. PMID: 8595170.
El-Naggar AK, Hurr K, Huff V, Luna MA, Goepfert H, Batsakis JG. Allelic loss and replication errors at microsatellite loci on chromosome 11p in head and neck squamous carcinoma: association with aggressive biological features. Clin Cancer Res 2:903-907, 1996. e-Pub 1996. PMID: 9816248.
El-Naggar AK, Lovell M, Killary AM, Batsakis JG. Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ hybridization, and DNA ploidy analysis. Cancer Genet Cytogenet 89:38-43, 1996. e-Pub 1996. PMID: 8689608.
El-Naggar AK, Hurr K, Huff V, Clayman GL, Luna MA, Batsakis JG. Microsatellite instability in preinvasive and invasive head and neck squamous carcinoma. Am J Pathol 148:2067-2072, 1996. e-Pub 1996. PMID: 8669490.
Colome MI, Ro JY, Ayala AG, El-Naggar AK, Siddiqui RT, NG: O. Adenoid cystic carcinoma of the breast metastatic to the kidney. . Int J Urol 4:69-78, 1996. e-Pub 1996.
Steck K, McDonnell T, Sneige N, El-Naggar AK. Flow cytometric analysis of apoptosis and bcl-2 in primary breast carcinomas: clinical and biological implications. Cytometry 24:116-122, 1996. e-Pub 1996. PMID: 8725660.
Beckhardt RN, Kiyokawa N, Xi L, Liu TJ, Hung MC, el-Naggar AK, Zhang HZ, Clayman GL. HER-2/neu oncogene characterization in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 121(11):1265-70, 1995. e-Pub 1995. PMID: 7576473.
Batsakis JG, el-Naggar AK, Luna MA. Teratomas of the head and neck with emphasis on malignancy. Ann Otol Rhinol Laryngol 104(6):496-500, 1995. e-Pub 1995. PMID: 7771726.
Batsakis JG, el-Naggar AK, Luna MA, Goepfert H. "Inflammatory pseudotumor": what is it? How does it behave?. Ann Otol Rhinol Laryngol 104(4 Pt 1):329-31, 1995. e-Pub 1995. PMID: 7717628.
Cho KJ, El-Naggar AK, Ordonez NG, Luna MA, Austin J, Batsakis JG. Epithelial-myoepithelial carcinoma of salivary glands. A clinicopathologic, DNA flow cytometric, and immunohistochemical study of Ki-67 and HER-2/neu oncogene. Am J Clin Pathol 103:432-437, 1995. e-Pub 1995. PMID: 7726139.
El-Naggar AK, Hurr K, Batsakis JG, Luna MA, Goepfert H, Huff V. Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma. Cancer Res 55:2656-2659, 1995. e-Pub 1995. PMID: 7780981.
Wojcik EM, Katz RL, Fanning TV, El-Naggar AK, Ordonez NG, Johnston D. Diagnosis of mantle cell lymphoma on tissue acquired by fine needle aspiration in conjunction with immunocytochemistry and cytokinetic studies. Possibilities and limitations. Acta Cytol 39:909-915, 1995. e-Pub 1995. PMID: 7571969.
Aydin A, El-Naggar AK, Robertson LE, Keating MJ, Huh YO. IL-2 receptor expression and KI-67 flow cytometric analysis in B-chronic lymphocytic leukemia. . Int J Oncol 7:1433-1436, 1995. e-Pub 1995.
Xu XC, El-Naggar AK, Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am J Pathol 147:815-822, 1995. e-Pub 1995. PMID: 7677193.
Cervantes M, Zhou H, Sahin A, Dhingra K, Valero V, Ordonez N, El-Naggar AK, Hess K, Glassman A, S: S. p53 alterations show significant correlation with gene amplification and high S-phase index in breast carcinoma. . International Journal of Oncology 6:955-962, 1995. e-Pub 1995.
Hsu B, Marin MC, El-Naggar AK, Stephens LC, Brisbay S, McDonnell TJ. Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis. Oncogene 11:175-179, 1995. e-Pub 1995. PMID: 7624125.
Hicks MJ, El-Naggar AK, Flaitz CM, Luna MA, Batsakis JG. Histocytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clinicopathologic and flow cytometric investigation. Head Neck 17:89-95, 1995. e-Pub 1995. PMID: 7558818.
El-Naggar AK, Steck K, Batsakis JG. Heterogeneity of the proliferative fraction and cyclin D1/CCND1 gene amplification in head and neck squamous cell carcinoma. Cytometry 21:47-51, 1995. e-Pub 1995. PMID: 8529470.
Kemp BL, Silva EG, El-Naggar AK. Juvenile granulosa cell tumor of the ovary: Interphase cytogenetics for chromosomes 12 and X and flow cytometric DNA ploidy study. . International Journal of Oncology 7:661-665, 1995. e-Pub 1995.
Steck KD, McDonnell TJ, El-Naggar AK. Flow cytometric analysis of apoptosis and bcl-2 in human solid neoplasms. Cytometry 20:154-161, 1995. e-Pub 1995. PMID: 7664626.
Clayman GL, El-Naggar AK, Roth JA, Zhang WW, Goepfert H, Taylor DL, Liu TJ. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 55:1-6, 1995. e-Pub 1995. PMID: 7805018.
Rajagopal S, Huang S, Moskal TL, Lee BN, El-Naggar AK, Chakrabarty S. Epidermal growth factor expression in human colon and colon carcinomas: anti-sense epidermal growth factor receptor RNA down-regulates the proliferation of human colon cancer cells. Int J Cancer 62:661-667, 1995. e-Pub 1995. PMID: 7558411.
Roush GR, El-Naggar AK, Abdul-Karim FW. Granulosa cell tumor of ovary: a clinicopathologic and flow cytometric DNA analysis. Gynecol Oncol 56:430-434, 1995. e-Pub 1995. PMID: 7705680.
Liu TJ, El-Naggar AK, McDonnell TJ, Steck KD, Wang M, Taylor DL, Clayman GL. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res 55:3117-3122, 1995. e-Pub 1995. PMID: 7606733.
el-Kattan I, Redline RW, El-Naggar AK, Grimes MC, Abdul-Karim FW. Cytologic features of intraabdominal desmoplastic small round cell tumor. A case report. Acta Cytol 39:514-520, 1995. e-Pub 1995. PMID: 7539203.
Janot F, El-Naggar AK, Morrison RS, Liu TJ, Taylor DL, Clayman GL. Expression of basic fibroblast growth factor in squamous cell carcinoma of the head and neck is associated with degree of histologic differentiation. Int J Cancer 64:117-123, 1995. e-Pub 1995. PMID: 7615354.
Cho KJ, Ell-Naggar AK, Mahanupab P, Luna MA, Batsakis JG. Carcinoma ex-pleomorphic adenoma of the nasal cavity: a report of two cases. J Laryngol Otol 109:677-679, 1995. e-Pub 1995. PMID: 7561483.
El-Naggar AK, Troncoso P, Ordonez NG. Primary renal carcinoid tumor with molecular abnormality characteristic of conventional renal cell neoplasms. Diagn Mol Pathol 4:48-53, 1995. e-Pub 1995. PMID: 7735556.
Sahin AA, Sneige N, Ordonez NG, Singletary SE, Ro JY, El-Naggar AK, Ayala AG. Immunohistochemical assessment of cathepsin D in stages I and II node-negative breast cancer. . Appl Immunohistochemistry 2:15-21, 1995. e-Pub 1995.
Kanjilal S, Strom SS, Clayman GL, Weber RS, El-Naggar AK, Kapur V, Cummings KK, Hill LA, Spitz MR, Kripke ML, Ananthaswang HN. p53 mutations in nonmelanoma skin cancer of the head and neck: molecular evidence for field cancerization. Cancer Res 55:3604-3609, 1995. e-Pub 1995. PMID: 7627969.
Lee JE, Berger DH, El-Naggar AK, Hickey RC, Vassilopoulou-Sellin R, Gagel RF, Burgess MA, Evans DB. Surgical management, DNA content, and patient survival in adrenal cortical carcinoma. Surgery 118:1090-1098, 1995. e-Pub 1995. PMID: 7491528.
Giannoni C, El-Naggar AK, Ordonez NG, Tu ZN, Austin J, Luna MA, Batsakis JG. c-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasms. Otolaryngol Head Neck Surg 112:391-398, 1995. e-Pub 1995. PMID: 7870438.
El-Naggar AK, Lai S, Luna MA, Zhou XD, Weber RS, Goepfert H, Batsakis JG. Sequential p53 mutation analysis of pre-invasive and invasive head and neck squamous carcinoma. Int J Cancer 64:196-201, 1995. e-Pub 1995. PMID: 7622308.
Lai, Batsakis JG, Ordonez NG, Luna MA, Goepfert H, AK: E. Genotypic and phenotypic alterations of p53 in head and neck squamous cell carcinoma. . Oncology Report 2:1115-1120, 1995. e-Pub 1995.
El-Naggar AK, Hurr K, Tu ZN, Tucker SL, Swanson D, Hsu PH. Interphase cytogenetics of renal cortical neoplasms. Correlation with DNA ploidy by flow cytometry. Am J Clin Pathol 104:141-149, 1995. e-Pub 1995. PMID: 7639187.
Klijanienko J, El-Naggar AK, de Braud F, Rodriguez-Peralto JL, Rodriguez R, Itzhaki M, Russo A, Janot F, Luboinski B, Cvitkovic E. Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas. Cancer 75:1649-1656, 1995. e-Pub 1995. PMID: 8826923.
Callender TA, Weber RS, Janjan N, Benjamin R, Zaher M, Wolf P, El-Naggar AK. Rhabdomyosarcoma of the nose and paranasal sinuses in adults and children. Otolaryngol Head Neck Surg 112:252-257, 1995. e-Pub 1995. PMID: 7838548.
El-Naggar AK, Hurr K, Tu ZN, Teague K, Raymond KA, Ayala AG, Murray J. DNA and RNA content analysis by flow cytometry in the pathobiologic assessment of bone tumors. Cytometry 19:256-262, 1995. e-Pub 1995. PMID: 7736870.
Sahin AA, Ro JY, Brown RW, Ordonez NG, Cleary KR, el-Naggar AK, Wilson P, Ayala AG. Assessment of Ki-67-derived tumor proliferative activity in colorectal adenocarcinomas. Mod Pathol 7(1):17-22, 1994. e-Pub 1994. PMID: 8159647.
Pollack A, Zagars GK, El-Naggar AK, Gauwitz MD, Terry NH. Near-diploidy: a new prognostic factor for clinically localized prostate cancer treated with external beam radiation therapy. Cancer 73:1895-1903, 1994. e-Pub 1994. PMID: 7511039.
Batsakis JG, El-Naggar AK, Weber RS. Two perplexing skin tumors: microcystic adnexal carcinoma and keratoacanthoma. Ann Otol Rhinol Laryngol 103:829-832, 1994. e-Pub 1994. PMID: 7944178.
El-Naggar AK, Lovell M, Killary A, Batsakis JG. Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland. Cancer Genet Cytogenet 76:96-99, 1994. e-Pub 1994. PMID: 7923075.
Zavala-Pompa A, Ro JY, El-Naggar AK, Amin MB, Ordonez NG, Sella A, Ayala AG. Tubular seminoma. An immunohistochemical and DNA flow-cytometric study of four cases. Am J Clin Pathol 102:397-401, 1994. e-Pub 1994. PMID: 7524297.
Pollack A, Zagars GK, E-Naggar AK, Terry NH. Relationship of tumor DNA-ploidy to serum prostate-specific antigen doubling time after radiotherapy for prostate cancer. Urology 44:711-718, 1994. e-Pub 1994. PMID: 7526527.
Buzaid A, Legha SS, Balch CM, Ross M, Ring S, Plager C, Papadopoulos NE, El-Naggar AK, Benjamin RS. Pilot study of preoperative chemotherapy with cisplatin, vinblastine, and dacarbazine in patients with local-regional recurrence of melanoma. Cancer 74:2476-2482, 1994. e-Pub 1994. PMID: 7923003.
Ro JY, Guerrieri C, El-Naggar AK, Ordonez NG, Sorge JG, Ayala AG. Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. Arch Pathol Lab Med 118:551-556, 1994. e-Pub 1994. PMID: 7514864.
Callender T, El-Naggar AK, Lee MS, Frankenthaler R, Luna MA, Batsakis JG. PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer 74:152-158, 1994. e-Pub 1994. PMID: 8004570.
Clayman GL, Stewart MG, Weber RS, El-Naggar AK, Grimm EA. Human papillomavirus in laryngeal and hypopharyngeal carcinomas. Relationship to survival. Arch Otolaryngol Head Neck Surg 120:743-748, 1994. e-Pub 1994. PMID: 8018327.
Carrillo R, Sneige N, El-Naggar AK. Interphase nucleolar organizer regions in the evaluation of serosal cavity effusions. Acta Cytol 38:367-372, 1994. e-Pub 1994. PMID: 8191825.
Ordonez, El-Naggar AK, Ro JY, Silva EG, B: M. Argyrophil cell differentiation of Wilms’ tumor (To the Editor). . Human Pathology 25:109-110, 1994. e-Pub 1994.
Press, Pike MC, Hung G, Zhou JY, George J, Dietz-Bank J, James W, Slamon DJ, Batsakis JG, AK: E. Amplification and overexpression of HER-2/neu in carcinoma of the salivary gland: Correlation with poor prognosis. . Cancer Research 54:5675-5682, 1994. e-Pub 1994.
Sanchez Y, El-Naggar AK, Pathak S, Killary AM. A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci U S A 91:3383-3387, 1994. e-Pub 1994. PMID: 8159756.
Batsakis JG, El-Naggar AK, Luna MA. Hyalinizing clear cell carcinoma of salivary origin. Ann Otol Rhinol Laryngol 103:746-748, 1994. e-Pub 1994. PMID: 8085740.
El-Naggar AK, Barlogie B, McCabe K, Teague K, Ensign LG, Pollock RE. Acridine orange DNA/RNA content analysis of soft-tissue tumors: Correlation with clinicopathologic factors and biological behavior. CMS 1:237-247, 1994. e-Pub 1994.
Frankenthaler RA, El-Naggar AK, Ordonez NG, Miller TS, Batsakis JG. High correlation with survival of proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of the parotid gland. Otolaryngol Head Neck Surg 111:460-466, 1994. e-Pub 1994. PMID: 7936679.
Steck K, El-Naggar AK. Comparative flow cytometric analysis of Ki-67 and proliferating cell nuclear antigen (PCNA) in solid neoplasms. Cytometry 17:258-265, 1994. e-Pub 1994. PMID: 7851161.
Chandler D, El-Naggar AK, Brisbay S, Redline RW, McDonnell TJ. Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: evidence for the contribution of bcl-2 expression to renal carcinogenesis. Hum Pathol 25:789-796, 1994. e-Pub 1994. PMID: 7520019.
Batsakis JG, El-Naggar AK. Pseudosarcomatous proliferative lesions of soft tissues. Ann Otol Rhinol Laryngol 103:578-582, 1994. e-Pub 1994. PMID: 8024223.
Marin MC, Hsu B, Meyn RE, Donehower LA, El-Naggar AK, McDonnell TJ. Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis. Oncogene 9:3107-3112, 1994. e-Pub 1994. PMID: 7936633.
Manning JT, Jr, Pugh WC, El-Naggar AK, Ordonez NG. Mediastinal lymphoblastic lymphoma with non-lymphoblastic histologic features. Mod Pathol 7:59-63, 1994. e-Pub 1994. PMID: 8159654.
Mackay B, El-Naggar AK, Ordonez NG. Ultrastructure of adrenal cortical carcinoma. Ultrastruct Pathol 18:181-190, 1994. e-Pub 1994. PMID: 8191624.
El-Naggar AK, Pflatz M, Ordonez NG, Batsakis JG. Tumors of the middle ear and endolymphatic sac. Pathol Annu 29 ( Pt 2):199-231, 1994. e-Pub 1994. PMID: 7936748.
Hicks MJ, El-Naggar AK, Byers RM, Flaitz CM, Luna MA, Batsakis JG. Prognostic factors in mucoepidermoid carcinomas of major salivary glands: a clinicopathologic and flow cytometric study. Eur J Cancer B Oral Oncol 30B:329-334, 1994. e-Pub 1994. PMID: 7703802.
Heaton KM, El-Naggar AK, Ensign LG, Ross MI, Balch CM. Surgical management and prognostic factors in patients with subungual melanoma. Ann Surg 219:197-204, 1994. e-Pub 1994. PMID: 8129491.
Teague K, El-Naggar AK. Comparative flow cytometric analysis of proliferating cell nuclear antigen (PCNA) antibodies in human solid neoplasms. Cytometry 15:21-27, 1994. e-Pub 1994. PMID: 7909288.
Yildiz I, Jaffe N, Aksoy F, El-Naggar AK. Regional DNA content heterogeneity in Wilms' tumor: incidence and potential clinical relevance. Anticancer Res 14:1365-1369, 1994. e-Pub 1994. PMID: 8067707.
El-Naggar AK, van Dekken HD, Ensign LG, Pathak S. Interphase cytogenetics in paraffin-embedded sections from renal cortical neoplasms. Correlation with cytogenetic and flow cytometric DNA ploidy analyses. Cancer Genet Cytogenet 73:134-141, 1994. e-Pub 1994. PMID: 8174088.
Gauwitz MD, Pollack A, El-Naggar AK, Terry NH, von Eschenbach AC, Zagars GK. The prognostic significance of DNA ploidy in clinically localized prostate cancer treated with radiation therapy. Int J Radiat Oncol Biol Phys 28:821-828, 1994. e-Pub 1994. PMID: 8138434.
Scheele, Ro JY, Ordonez NG, El-Naggar AK, Grignon DJ, Sprague RI, Detweiler J, AG: A. Stages B and C transitional cell carcinomas of the bladder: Prognostic significance of collagen type IV immunostaining patterns and their comparison with other clinicopathologic prognosticators. . J Urologic Pathology 2:121-133, 1993. e-Pub 1993.
Stern SJ, Goepfert H, Clayman G, Byers R, Ang KK, El-Naggar AK, Wolf P. Squamous cell carcinoma of the maxillary sinus. Arch Otolaryngol Head Neck Surg 119:964-969, 1993. e-Pub 1993. PMID: 8357597.
Ordonez NG, El-Naggar AK, Ro JY, Silva EG, Mackay B. Intra-abdominal desmoplastic small cell tumor: a light microscopic, immunocytochemical, ultrastructural, and flow cytometric study. Hum Pathol 24:850-865, 1993. e-Pub 1993. PMID: 8375856.
Heaton KM, Rippon MB, El-Naggar AK, Tucker SL, Ross MI, Balch CM. Prognostic implications of DNA index in patients with stage III cutaneous melanoma. Am J Surg 166:648-652, 1993. e-Pub 1993. PMID: 8273843.
Ro JY, El-Naggar AK, Amin MB, Sahin AA, Ordonez NG, Ayala AG. Pseudosarcomatous fibromyxoid tumor of the urinary bladder and prostate: immunohistochemical, ultrastructural, and DNA flow cytometric analyses of nine cases. Hum Pathol 24:1203-1120, 1993. e-Pub 1993. PMID: 7503934.
Katz RL, Wojcik EM, El-Naggar AK, Ordonez NG, Johnston DA. Proliferation markers in non-Hodgkin's lymphoma. A comparative study between cytophotometric quantitation of Ki-67 and flow cytometric proliferation index on fine needle aspirates. Anal Quant Cytol Histol 15:179-186, 1993. e-Pub 1993. PMID: 8347257.
El-Naggar AK, Gaber K, Ordonez NG. Renal cell carcinoma with osteoclast-like giant cells. Virchows Arch A Pathol Anat Histopathol 422:427-431, 1993. e-Pub 1993. PMID: 8322459.
Batsakis JG, Hybels RD, El-Naggar AK. Solitary fibrous tumor. Ann Otol Rhinol Laryngol 102:74-76, 1993. e-Pub 1993. PMID: 8420474.
Klijanienko J, El-Naggar A, Ponzio-Prion A, Marandas P, Micheau C, Caillaud JM. Basaloid squamous carcinoma of the head and neck. Immunohistochemical comparison with adenoid cystic carcinoma and squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 119:887-890, 1993. e-Pub 1993. PMID: 8393682.
El-Naggar AK, Ro JY, Ensign LG. Papillary renal cell carcinoma: clinical implication of DNA content analysis. Hum Pathol 24:316-321, 1993. e-Pub 1993. PMID: 8454276.
El-Naggar AK, Lee MS, Wang G, Luna MA, Goepfert H, Batsakis JG. Polymerase chain reaction-based restriction fragment length polymorphism analysis of the short arm of chromosome 3 in primary head and neck squamous carcinoma. Cancer 72:881-886, 1993. e-Pub 1993. PMID: 8101470.
Ordonez NG, Mackay B, El-Naggar AK, Bannayan GA, Duncan J. Clear cell carcinoid tumour of the stomach. Histopathology 22:190-193, 1993. e-Pub 1993. PMID: 8454267.
Cajulis RS, Katz RL, Dekmezian R, El-Naggar AK, Ro JY. Fine needle aspiration biopsy of renal cell carcinoma. Cytologic parameters and their concordance with histology and flow cytometric data. Acta Cytol 37:367-372, 1993. e-Pub 1993. PMID: 8498138.
Batsakis JG, El-Naggar AK. Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies. Ann Otol Rhinol Laryngol 102:906-908, 1993. e-Pub 1993. PMID: 8239356.
Batsakis JG, El-Naggar AK. Papillary neoplasms (Heffner's tumors) of the endolymphatic sac. Ann Otol Rhinol Laryngol 102:648-651, 1993. e-Pub 1993. PMID: 8352492.
Carrillo R, Batsakis JG, Weber R, Luna MA, El-Naggar AK. Salivary neoplasms of the palate: a flow cytometric and clinicopathological analysis. J Laryngol Otol 107:858-861, 1993. e-Pub 1993. PMID: 8228611.
Klijanienko J, El-Naggar AK, De Braud F, Micheau C, Janot F, Luboinski B, Gentile A, Russo A, Cvitkovic E. Keratins 6, 13 and 19. Differential expression in squamous cell carcinoma of the head and neck. Anal Quant Cytol Histol 15:335-340, 1993. e-Pub 1993. PMID: 7505082.
Ordonez NG, Mackay B, El-Naggar AK, Byers RM. Congenital hemangiopericytoma. An ultrastructural, immunocytochemical, and flow cytometric study. Arch Pathol Lab Med 117:934-937, 1993. e-Pub 1993. PMID: 8368908.
El-Naggar AK, Batsakis JG, Ordonez NG, Luna MA, Goepfert H. Rhabdomyosarcoma of the adult head and neck: a clinicopathological and DNA ploidy study. J Laryngol Otol 107:716-720, 1993. e-Pub 1993. PMID: 8409724.
Wojcik EM, Katz RL, Johnston DA, Sembera D, El-Naggar AK. Comparative analysis of DNA ploidy and proliferative index in fine needle aspirates of non-Hodgkin's lymphomas by image analysis and flow cytometry. Anal Quant Cytol Histol 15:151-157, 1993. e-Pub 1993. PMID: 8347254.
El-Naggar AK, Batsakis JG, Wang G, Lee MS. PCR-based RFLP screening of the commonly deleted 3p loci in renal cortical neoplasms. Diagn Mol Pathol 2:269-276, 1993. e-Pub 1993. PMID: 7906993.
Clayman G, Wang SW, Nicolson GL, El-Naggar AK, Mazar A, Henkin J, Blasi F, Goepfert H, Boyd DD. Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity. Int J Cancer 54:73-80, 1993. e-Pub 1993. PMID: 8386710.
Carrillo R, Rodriquez-Peralto JL, Batsakis JG, el-Naggar AK. Primary haemangiopericytomas of the parotid gland. J Laryngol Otol 106(7):659-61, 1992. e-Pub 1992. PMID: 1527469.
Batsakis JG, El-Naggar AK, Luna MA. Epithelial-myoepithelial carcinoma of salivary glands. Ann Otol Rhinol Laryngol 101:540-542, 1992. e-Pub 1992. PMID: 1376977.
el-Naggar AK, Lopez-Varela V, Luna MA, Weber R, Batsakis JG. Intratumoral DNA content heterogeneity in laryngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 118(2):169-73, 1992. e-Pub 1992. PMID: 1540348.
Batsakis JG, El-Naggar AK, Luna MA. "Adenocarcinoma, not otherwise specified": a diminishing group of salivary carcinomas. Ann Otol Rhinol Laryngol 101:102-104, 1992. e-Pub 1992. PMID: 1728879.
Shin DM, El-Naggar AK, Putnam JB, Komaki R, Hong WK. Case reports: Pathologic remission of invasive thymoma after induction chemotherapy. The Cancer Bulletin 44:346-348, 1992. e-Pub 1992.
Mourad WA, Katz RL, Sembera D, Atkinson EN, el-Naggar AK. Two AgNOR counts in fine-needle aspirates of lymphoproliferative disorders compared with acridine orange flow cytometry. Diagn Cytopathol 8(2):128-34, 1992. e-Pub 1992. PMID: 1568410.
Batsakis JG, El-Naggar AK, Luna MA. Neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol 101:710-704, 1992. e-Pub 1992. PMID: 1323230.
Jacobs JC, Katz RL, Shabb N, El-Naggar AK, Ordonez NG, Pugh W. Fine needle aspiration of lymphoblastic lymphoma. A multiparameter diagnostic approach. Acta Cytol 36:887-894, 1992. e-Pub 1992. PMID: 1449027.
Mulhollan TJ, Ro JY, El-Naggar AK, Sahin AA, Ayala AG. Granular cell tumor of the biliary tree. Am J Surg Pathol 16:204-206, 1992. e-Pub 1992. PMID: 1733352.
Pollack A, El-Naggar AK, Cox JD, Ro JY, Sahin A, Komaki R. Thymoma. The prognostic significance of flow cytometric DNA analysis. Cancer 69:1702-1709, 1992. e-Pub 1992. PMID: 1551054.
Carrillo, Rodreguez-Peralto JL, Batsakis JG, El-Naggar AK. Pathology in focus: Primary hemangiopericytomas of the parotid gland. . J Laryngology & Otology 106:659-661, 1992. e-Pub 1992.
Voravud N, El-Naggar AK, Balch CM, Theriault RL. Metastatic lobular breast carcinoma simulating primary colon cancer. Am J Clin Oncol 15:365-369, 1992. e-Pub 1992. PMID: 1514536.
El-Naggar AK, Batsakis JG, Garcia GM, Luna ML, Goepfert H. Sinonasal hemangiopericytomas. A clinicopathologic and DNA content study. Arch Otolaryngol Head Neck Surg 118:134-137, 1992. e-Pub 1992. PMID: 1540341.
El-Naggar AK, Ro JY, McLemore D, Ayala AG, Batsakis JG. DNA ploidy in testicular germ cell neoplasms. Histogenetic and clinical implications. Am J Surg Pathol 16:611-618, 1992. e-Pub 1992. PMID: 1318004.
Gomez R, El-Naggar AK, Byers RM, Garnsey L, Luna MA, Batsakis JG. Squamous carcinoma of oral tongue: prognostic significance of flow-cytometric DNA content. Mod Pathol 5:141-145, 1992. e-Pub 1992. PMID: 1574491.
del Giglio A, O'Brien S, Ford R, Saya H, Manning J, Keating M, Johnston D, Khetan R, El-Naggar AK, Deisseroth A. Prognostic value of proliferating cell nuclear antigen expression in chronic lymphoid leukemia. Blood 79:2717-2720, 1992. e-Pub 1992. PMID: 1350226.
Batsakis JG, El-Naggar AK. Rhinoscleroma and rhinosporidiosis. Ann Otol Rhinol Laryngol 101:879-882, 1992. e-Pub 1992. PMID: 1416645.
Abdul-Karim FW, El-Naggar AK, Joyce MJ, Makley JT, Carter JR. Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. Hum Pathol 23:729-735, 1992. e-Pub 1992. PMID: 1319390.
El-Naggar AK, Lopez-Varela V, Luna MA, Weber R, Batsakis JG. Intratumoral DNA content heterogeneity in laryngeal squamous carcinoma. Arch Otolaryngol Head Neck Surg 2:169-173, 1992. e-Pub 1992.
Misra, Parihar AL, El-Naggar AK. Exclusion of residual angiosarcoma of the breast by MRI. Breast Cancer Res Treat 21:221-224, 1992. e-Pub 1992.
Tornos C, Silva EG, El-Naggar AK, Burke TW. Aggressive stage I grade 1 endometrial carcinoma. Cancer 70:790-798, 1992. e-Pub 1992. PMID: 1643610.
El-Naggar AK, Garcia GM. Epithelioid sarcoma. Flow cytometric study of DNA content and regional DNA heterogeneity. Cancer 69:1721-1728, 1992. e-Pub 1992. PMID: 1551057.
Carrillo R, El-Naggar AK, Luna MA, Rodriguez-Peralto JL, Batsakis JG. Nucleolar organizer regions (NORs) and myoepitheliomas: a comparison with DNA content and clinical course. J Laryngol Otol 106:616-620, 1992. e-Pub 1992. PMID: 1382110.
Hartwick RW, El-Naggar AK, Ro JY, Srigley JR, McLemore DD, Jones EC, Grignon DJ, Thomas MJ, Ayala AG. Renal oncocytoma and granular renal cell carcinoma. A comparative clinicopathologic and DNA flow cytometric study. Am J Clin Pathol 98:587-593, 1992. e-Pub 1992. PMID: 1462956.
Batsakis JG, Sneige N, El-Naggar AK. Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 101:185-188, 1992. e-Pub 1992. PMID: 1739267.
Shahab I, Fraire AE, Greenberg SD, Mawad J, AK: E. A clinically aggressive, solitary fibrous mediastinal tumor exhibiting a diploid stemline pattern. . Houston Medicine 8:23-26, 1992. e-Pub 1992.
Graham RA, Teague K, McLemore D, Cleary K, El-Naggar AK. Regional DNA content heterogeneity in colonic adenocarcinoma: prognostic significance in patients with liver metastases. J Surg Oncol 50:228-232, 1992. e-Pub 1992. PMID: 1640705.
El-Naggar AK, Pathak S. Cytogenetic and corresponding flow cytometric DNA analysis of renal cell neoplasms. Anticancer Res 12:1491-1500, 1992. e-Pub 1992. PMID: 1444211.
el-Naggar AK, Abdul-Karim FW, Silva EG, McLemore D, Garnsey L. Uterine stromal neoplasms: a clinicopathologic and DNA flow cytometric correlation. Hum Pathol 22(9):897-903, 1991. e-Pub 1991. PMID: 1916750.
Robey-Cafferty SS, el-Naggar AK, Sahin AA, Bruner JM, Ro JY, Cleary KR. Prognostic factors in esophageal squamous carcinoma. A study of histologic features, blood group expression, and DNA ploidy. Am J Clin Pathol 95(6):844-9, 1991. e-Pub 1991. PMID: 2042594.
Ro JY, Sahin AA, el-Naggar AK, Ordonez NG, Mackay B, Llamas LL, Ayala AG. Intraluminal crystalloids in struma ovarii. Immunohistochemical, DNA flow cytometric, and ultrastructural study. Arch Pathol Lab Med 115(2):145-149, 1991. e-Pub 1991. PMID: 1992980.
el-Naggar AK, Ordonez NG, Batsakis JG. Parotid gland plasmacytoma with crystalline deposits. Oral Surg Oral Med Oral Pathol 71(2):206-208, 1991. e-Pub 1991. PMID: 1848362.
El-Naggar AK, Abdul-Karim FW, Silva E, McLemore D, Garnsey L. Uterine stromal neoplasms: a clinicopathologic and DNA flow cytometric correlation. Hum Pathol 22:897-903, 1991. e-Pub 1991.
Batsakis JG, El-Naggar AK. Terminal duct adenocarcinomas of salivary tissues. Ann Otol Rhinol Laryngol 100:251-253, 1991. e-Pub 1991. PMID: 2006826.
Sahin AA, Ro J, Ro JY, Blick MB, El-Naggar AK, Ordonez NG, Fritsche HA, Smith TL, Hortobagyi GN, Ayala AG. Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis. Cancer 68:549-557, 1991. e-Pub 1991. PMID: 1648433.
El-Naggar AK, Ordonez NG, Garnsey L, Batsakis JG. Epithelioid pleural mesotheliomas and pulmonary adenocarcinomas: a comparative DNA flow cytometric study. Hum Pathol 22:972-978, 1991. e-Pub 1991. PMID: 1842386.
El-Naggar AK, Ro JY, Sella A, Ayala AG. Simultaneous renal and transitional cell carcinomas in same kidney with subsequent lymph node metastasis: DNA flow cytometric study. Urology 38:585-588, 1991. e-Pub 1991. PMID: 1746094.
Sella, El-Naggar AK, Ro JY, et al. DNA ploidy in mature testicular teratoma. J Urol 146:1025-1028, 1991. e-Pub 1991.
Sahin, Ro JY, El-Naggar AK, Ordonez NG, Babaian RJ, Ayala AG. Pseudosarcomatous fibromyxoid tumor of the prostate: A case report with immunohistochemical, electron microscopic, and DNA flow cytometric analysis. Am J Clin Pathol 96:253-258, 1991. e-Pub 1991.
Frauenhoffer EE, Ro JY, Silva EG, El-Naggar AK. Well-differentiated serous ovarian carcinoma presenting as a breast mass: a case report and flow cytometric DNA study. Int J Gynecol Pathol 10:79-87, 1991. e-Pub 1991. PMID: 2007537.
Frauenhoffer EE, Ro JY, El-Naggar AK, Ordonez NG, Ayala AG. Clear cell cribriform hyperplasia of the prostate. Immunohistochemical and DNA flow cytometric study. Am J Clin Pathol 95:446-453, 1991. e-Pub 1991. PMID: 1707587.
El-Naggar AK, Ordonez NG, Sara A, McLemore D, Batsakis JG. Clear cell sarcomas and metastatic soft tissue melanomas. A flow cytometric comparison and prognostic implications. Cancer 67:2173-2179, 1991. e-Pub 1991. PMID: 2004337.
El-Naggar AK, Evans DB, Mackay B. Oncocytic adrenal cortical carcinoma. Ultrastruct Pathol 15:549-556, 1991. e-Pub 1991. PMID: 1755111.
Shabb N, Katz R, Ordonez N, Goodacre A, Hirsch-Ginsberg C, El-Naggar AK. Fine-needle aspiration evaluation of lymphoproliferative lesions in human immunodeficiency virus-positive patients. A multiparameter approach. Cancer 67:1008-1018, 1991. e-Pub 1991. PMID: 1991248.
el-Naggar AK, Batsakis JG, Teague K, Garnsey L, Barlogie B. Single- and double-stranded RNA measurements by flow cytometry in solid neoplasms. Cytometry 12(4):330-335, 1991. e-Pub 1991. PMID: 2065558.
Ayala, Ro JY, AK: E. DNA flow cytometry in prostatic carcinoma. Pathologica 23:137-138, 1991. e-Pub 1991.
El-Naggar AK, Batsakis JG, Vassilopoulou-Sellin R, Ordonez NG, Luna MA. Medullary (thyroid) carcinoma-like carcinoids of the larynx. J Laryngol Otol 105:683-686, 1991. e-Pub 1991. PMID: 1919332.
El-Naggar AK, Ballance W, Karim FW, Ordonez NG, McLemore D, Giacco GG, Batsakis JG. Typical and atypical bronchopulmonary carcinoids. A clinicopathologic and flow cytometric study. Am J Clin Pathol 95:828-834, 1991. e-Pub 1991. PMID: 2042593.
Sneige N, Dekmezian R, El-Naggar AK, Manning J. Cytomorphologic, immunocytochemical, and nucleic acid flow cytometric study of 50 lymph nodes by fine-needle aspiration. Comparison with results obtained by subsequent excisional biopsy. Cancer 67:1003-1007, 1991. e-Pub 1991. PMID: 1991247.
Sahin AA, Ro JY, El-Naggar AK, Wilson PL, Teague K, Blick M, Ayala AG. Tumor proliferative fraction in solid malignant neoplasms. A comparative study of Ki-67 immunostaining and flow cytometric determinations. Am J Clin Pathol 96:512-519, 1991. e-Pub 1991. PMID: 1716414.
Ordonez NG, El-Naggar AK, Hickey RC, Samaan NA. Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am J Clin Pathol 96:15-24, 1991. e-Pub 1991. PMID: 1712540.
Sara A, El-Naggar AK. Intratumoral DNA content variability. A study of non-small cell lung cancer. Am J Clin Pathol 96:311-317, 1991. e-Pub 1991. PMID: 1652200.
Sahin AA, Ro JY, Ordoñez NG, Luna MA, el-Naggar AK, Goepfert H, Ayala AG. Myofibroblastoma of the tongue. An immunohistochemical, ultrastructural, and flow cytometric study. Am J Clin Pathol 94(6):773-777, 1990. e-Pub 1990. PMID: 1700879.
el-Naggar AK, Ordonez NG, McLemore D, Schultz P, Hickey RC, Samaan N. Clinicopathologic and flow cytometric DNA study of medullary thyroid carcinoma. Surgery 108(6):981-985, 1990. e-Pub 1990. PMID: 2247844.
el-Naggar AK, Batsakis JG, Teague K, Giacco G, Guinee VF, Swanson D. Acridine orange flow cytometric analysis of renal cell carcinoma. Clinicopathologic implications of RNA content. Am J Pathol 137(2):275-280, 1990. e-Pub 1990. PMID: 2386196.
El-Naggar AK, Mackay B, Sneige N, Batsakis JG. Stromal neoplasms of the breast: a comparative flow cytometric study. J Surg Oncol 44(3):151-156, 1990. e-Pub 1990. PMID: 2164618.
el-Naggar AK, Ayala AG, Abdul-Karim FW, McLemore D, Ballance WW, Garnsey L, Ro JY, Batsakis JG. Synovial sarcoma. A DNA flow cytometric study. Cancer 65(10):2295-2300, 1990. e-Pub 1990. PMID: 2161280.
Batsakis JG, el-Naggar AK. Sebaceous lesions of salivary glands and oral cavity. Ann Otol Rhinol Laryngol 99(5 Pt 1):416-418, 1990. e-Pub 1990. PMID: 2337322.
Robey-Cafferty SS, el-Naggar AK, Grignon DJ, Cleary KR, Ro JY. Histologic parameters and DNA ploidy as predictors of survival in stage B adenocarcinoma of colon and rectum. Mod Pathol 3(3):261-6, 1990. e-Pub 1990. PMID: 2362936.
el-Naggar AK, Batsakis JG, Luna MA, McLemore D, Byers RM. DNA flow cytometry of acinic cell carcinomas of major salivary glands. J Laryngol Otol 104(5):410-416, 1990. e-Pub 1990. PMID: 2370468.
el-Naggar AK, Ro JY, McLemore D, Garnsy L. DNA content and proliferative activity of cystosarcoma phyllodes of the breast. Potential prognostic significance. Am J Clin Pathol 93(4):480-485, 1990. e-Pub 1990. PMID: 2157332.
Sahin AA, Ro JY, el-Naggar AK, Lee JS, Ayala AG, Teague K, Hong WK. Flow cytometric analysis of the DNA content of non-small cell lung cancer. Ploidy as a significant prognostic indicator in squamous cell carcinoma of the lung. Cancer 65(3):530-537, 1990. e-Pub 1990. PMID: 2153432.
Sara AS, Ayala AG, El-Naggar AK, Ro JY, Raymond AK, Murray JA. Giant cell tumor of bone. A clinicopathologic and DNA flow cytometric analysis. Cancer 66:2186-2190, 1990. e-Pub 1990. PMID: 2224773.
Robe-Cafferty, El-Naggar AK, Grignon D, Cleary K, Ro JY. Clinicopathologic and DNA flow cytometric study of stage-B colon and rectal carcinomas. . Mod Pathol 3:261-266, 1990. e-Pub 1990.
Ro JY, Ayala AG, Tetu B, Ordonez NG, El-Naggar AK, Grignon DJ, Mackay B. Merkel cell carcinoma metastatic to the testis. Am J Clin Pathol 94:384-389, 1990. e-Pub 1990. PMID: 1699405.
Grignon DJ, Ayala AG, Ro JY, El-Naggar AK, Papadopoulos NJ. Primary sarcomas of the kidney. A clinicopathologic and DNA flow cytometric study of 17 cases. Cancer 65:1611-1168, 1990. e-Pub 1990. PMID: 2155701.
Luna MA, El-Naggar AK, Parichatikanond P, Weber RS, Batsakis JG. Basaloid squamous carcinoma of the upper aerodigestive tract. Clinicopathologic and DNA flow cytometric analysis. Cancer 66:537-542, 1990. e-Pub 1990. PMID: 2364364.
Corkill ME, Sneige N, Fanning T, El-Naggar AK. Fine-needle aspiration cytology and flow cytometry of intracystic papillary carcinoma of breast. Am J Clin Pathol 94:673-680, 1990. e-Pub 1990. PMID: 2244588.
Luna MA, El-Naggar AK, Batsakis JG, Weber RS, Garnsey LA, Goepfert H. Flow cytometric DNA content of adenoid cystic carcinoma of submandibular gland. Correlation of histologic features and prognosis. Arch Otolaryngol Head Neck Surg 116:1291-1296, 1990. e-Pub 1990. PMID: 2173619.
Tornos C, Silva E, El-Naggar AK, Pritzker KP. Calcium oxalate crystals in breast biopsies. The missing microcalcifications. Am J Surg Pathol 14:961-968, 1990. e-Pub 1990. PMID: 1698342.
Ro JY, Ayala AG, El-Naggar AK, Grignon DJ, Hogan SF, Howard DR. Angiomyolipoma of kidney with lymph node involvement. DNA flow cytometric analysis. Arch Pathol Lab Med 114:65-67, 1990. e-Pub 1990. PMID: 2294869.
Ro JY, El-Naggar AK, Holmes FA, Close D, Hortobagyi GN. Brain Metastasis initial presentation of breast cancer: DNA flow cytometric comparison of two sites. . Breast 3:35-38, 1990. e-Pub 1990.
McLemore DD, El Naggar AK, Stephens LC, Jardine JH. Modified methodology to improve flow cytometric DNA histograms from paraffin-embedded material. Stain Technol 65:279-291, 1990. e-Pub 1990. PMID: 2080523.
el-Naggar AK, Ro JY, Ayala AG, Ward R, Ordóñez NG. Localized fibrous tumor of the serosal cavities. Immunohistochemical, electron-microscopic, and flow-cytometric DNA study. Am J Clin Pathol 92(5):561-565, 1989. e-Pub 1989. PMID: 2479254.
Grignon DJ, Ayala AG, El-Naggar AK, Wishnow KI, Ro JY, Swanson DA, McLemore D, Giacco GG, Guinee VF. Renal cell carcinoma. A clinicopathologic and DNA flow cytometric analysis of 103 cases. Cancer 64:2133-2140, 1989. e-Pub 1989. PMID: 2804902.
el-Naggar AK, Ro JY, McLemore D, Garnsey L, Ordonez N, MacKay B. Gastrointestinal stromal tumors: DNA flow-cytometric study of 58 patients with at least five years of follow-up. Mod Pathol 2(5):511-515, 1989. e-Pub 1989. PMID: 2554282.
el-Naggar AK, Ro JY, Ayala AG, Hinchey WW, Abdul-Karim FW, Batsakis JG. Angiomatoid malignant fibrous histiocytoma: flow cytometric DNA analysis of six cases. J Surg Oncol 40(3):201-204, 1989. e-Pub 1989. PMID: 2537444.
Rutledge ML, Silva EG, McLemore D, El-Naggar AK. Serous surface carcinoma of the ovary and peritoneum. A flow cytometric study. Pathol Annu 24:227-235, 1989. e-Pub 1989. PMID: 2771453.
Weber RS, Palmer JM, El-Naggar AK, McNeese MD, Guillamondegui OM, Byers RM. Minor salivary gland tumors of the lip and buccal mucosa. Laryngoscope 99:6-9, 1989. e-Pub 1989. PMID: 2535883.
Batsakis JG, EL-Naggar AK. Basaloid-squamous carcinomas of the upper aerodigestive tracts. Ann Otol Rhinol Laryngol 98:919-920, 1989. e-Pub 1989. PMID: 2817687.
El-Naggar AK, Batsakis JG, Luna MA, Goepfert H, Tortoledo ME. DNA content and proliferative activity of myoepitheliomas. J Laryngol Otol 103:1192-1197, 1989. e-Pub 1989. PMID: 2559135.
Ro JS, El-Naggar AK, Ro JY, Blick M, Frye D, Fraschini G, Fritsche H, Hortobagyi G. c-erbB-2 amplification in node-negative human breast cancer. Cancer Res 49:6941-6944, 1989. e-Pub 1989. PMID: 2573424.
Grignon DJ, El-Naggar AK, Green LK, Ayala AG, Ro JY, Swanson DA, Troncoso P, McLemore D, Giacco GG, Guinee VF. DNA flow cytometry as a predictor of outcome of stage I renal cell carcinoma. Cancer 63:1161-1165, 1989. e-Pub 1989. PMID: 2917319.
Grignon DJ, El-Naggar AK, Ro JY, Johnson DE, Ayala AG. Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder: an analysis of 36 cases. J Urol 142:1206-1210, 1989. e-Pub 1989. PMID: 2810494.
Robey SS, Silva EG, Gershenson DM, McLemore D, El-Naggar AK, Ordonez NG. Transitional cell carcinoma in high-grade high-stage ovarian carcinoma. An indicator of favorable response to chemotherapy. Cancer 63:839-847, 1989. e-Pub 1989. PMID: 2644014.
el-Naggar AK, Batsakis JG, Luna MA, Hickey RC. Hurthle cell tumors of the thyroid. A flow cytometric DNA analysis. Arch Otolaryngol Head Neck Surg 114(5):520-521, 1988. e-Pub 1988. PMID: 3355687.
Ro JY, El-Naggar AK, Ayala AG, Mody DR, Ordonez NG. Signet-ring-cell carcinoma of the prostate. Electron-microscopic and immunohistochemical studies of eight cases. Am J Surg Pathol 12:453-460, 1988. e-Pub 1988. PMID: 2454036.
El-Naggar AK, Abdul-Karim FW, Marshalleck JJ, Sorensen K. Fine-needle aspiration of fibromatosis of the breast. Diagn Cytopathol 3:320-322, 1987. e-Pub 1987. PMID: 3428067.
Ro JY, Ayala AG, El-Naggar AK, Wishnow KI. Seminal vesicle involvement by in situ and invasive transitional cell carcinoma of the bladder. Am J Surg Pathol 11:951-958, 1987. e-Pub 1987. PMID: 3688301.
Ro JY, Ayala AG, El-Naggar AK. Muscularis mucosa of urinary bladder. Importance for staging and treatment. Am J Surg Pathol 11:668-73, 1987. e-Pub 1987. PMID: 3631381.
Van Epps DE, El-Naggar AK, Ochs HD. Abnormalities of lymphocyte locomotion in immunodeficiency disease. Clin Exp Immunol 53:678-688, 1983. e-Pub 1983. PMID: 6616960.
El-Naggar AK, Higashi GI. In vivo and in vitro cell-mediated immunity in tuberculous meningitis. J Clin Lab Immunol 8(1):37-42, 1982. e-Pub 1982. PMID: 7047745.
El-Naggar AK, Higashi GI. Cell-mediated immunity in Tuberculous meningitis: Delayed-type hypersensitivity, T-lymphocytes and blastogenic transformation responses. J Clin Lab Immunol 8:37-42, 1982. e-Pub 1982.
El-Naggar AK, Van Epps DE, Williams RC, Jr. A human lymphocyte chemotactic factor produced by the mixed lymphocyte reaction. J Lab Clin Med 100:558-565, 1982. e-Pub 1982. PMID: 6214599.
El Naggar AK, Colley DG. Modulation of schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cels during chronic infection. Cell Immunol 72:151-156, 1982. e-Pub 1982. PMID: 6890878.
El-Naggar AK, Higashi GI. Tuberculous meningitis: E-rosette-forming T lymphocytes in cerebrospinal fluid. Neurology 31:610-612, 1981. e-Pub 1981. PMID: 6972016.
El-Naggar AK, Van Epps D, Jr WR. Effect of culturing on the human lymphocyte locomotion response to casein, Cda and f-Met-Leu-Phe. Cell Immunol 80:43-49, 1981. e-Pub 1981.
El-Naggar AK, Van Epps DE, Williams RC. Human-B and T-lymphocyte locomotion in response to casein, C5a, and f-met-leu-phe. Cell Immunol 56(2):365-373, 1980. e-Pub 1980. PMID: 6970626.
Reiner NE, Kamel R, Higashi GI, El-Naggar AK, Aguib M, Ellner JJ, Mahmoud AA. Concurrent responses of peripheral blood and splenic mononuclear cells to antigenic and mitogenic stimulation in human hepatosplenic schistosomiasis. J Infect Dis 140:162-168, 1979. e-Pub 1979. PMID: 314479.
Kamel K, Umar M, Ibrahim W, Mansour A, Gaballah F, Selim O, Azim A, Hamza S, Sabry F, Moafy N, El-Naggar AK, Hoerman K. Anthropological studies among Libyans. Erythrocyte genetic factors, serum haptoglobin phenotypes and anthropometry. Am J Phys Anthropol 43:103-111, 1975. e-Pub 1975. PMID: 808138.
Ibrahim WN, Kamel K, Selim O, Azim A, Gaballah MF, Sabry F, El-Naggar AK, Koerman K. Hereditary blood factors and anthropometry of inhabitants of the Egyptian Siwa Oasis. Hum Biol 46:57-68, 1974. e-Pub 1974.

Invited Articles

Wotman M, El-Naggar A, Ferrarotto R. Targeting human EGFR 2 (HER2) in salivary gland carcinoma. Expert Rev Anticancer Ther 23(6):573-582, 2023. e-Pub 2023. PMID: 37114470.
El-Naggar AK. Editor's perspective on the 4th edition of the WHO head and neck tumor classification. J Egypt Natl Canc Inst 29(2):65-66, 2017. e-Pub 2017. PMID: 28455004.
El-Naggar AK. John g. Batsakis, MD (1929-2013): a historical perspective on his contributions to pathology. Arch Pathol Lab Med 138(11):1424, 2014. e-Pub 2014. PMID: 25357103.
Adelstein DJ, Koyfman SA, El-Naggar AK, Hanna EY. Biology and management of salivary gland cancers. Semin Radiat Oncol 22(3):245-53, 2012. e-Pub 2012. PMID: 22687949.
Santarpia L, Lippman SM, El-Naggar AK. Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin Ther Targets 16(1):103-19, 2012. e-Pub 2012. PMID: 22239440.
El-Naggar AK. News in Brief: Mitochondrial DNA mutations in cancer diagnosis?. Advances in Anatomic Pathology 10:50-51, 2003. e-Pub 2003.
Batsakis JG, Medeiros JL, Luna MA, El-Naggar AK. Plasma cell dyscrasias and the head and neck. Ann Diagn Pathol 6:129-140, 2002. e-Pub 2002. PMID: 12004363.
El-Naggar AK. Methods in molecular surgical pathology. Semin Siagn Pathol 19:56-71, 2002. e-Pub 2002.
Klijanienko J, Vielh P, Batsakis JG, El-Naggar, Jelen M, Piekarski JG. Salivary gland tumours. Monogr Clin Cytol 15:1-138, 2000. e-Pub 2000.
Suarez P, Batsakis JG, El-Naggar AK. Leukoplakia: Still a gallimaufry or is progress being made? - A Review. Advances in Anatomic Pathology 5:137-155, 1998. e-Pub 1998.
J-C S, Vielh J, El-Naggar AK. Telomerase activity in cancer: A magic bullet or a mirage?. Advances in Anatomic Pathology 5:86-94, 1998. e-Pub 1998.
Batsakis JG, Suarez P, El-Naggar. Mucosal melanomas of the head and neck. Annals of Otology, Rhinology & Laryngology 107:626-630, 1998. e-Pub 1998.
Batsakis JG, El-Naggar AK. p53: Fifteen years after discovery. Advance in Anatomic Pathology 2:71-88, 1995. e-Pub 1995.
El-Naggar AK. MTS1/p16 INKA (CDKN2) Gene: The jury is still out. Advances in Anatomic Pathology 4:227-229, 1995. e-Pub 1995.
Klijanienko, Janot F, deBraud F, Russo A, Pignon JP, El-Naggar AK, Luboinski B, Cvitkovic E. Clinicopathological Grading in Head and Neck Squamous Cell Carcinoma (HNSCC). A prospective analysis of 108 Patients Treated Curatively. XVI International Cancer Congress:939-942, 1994. e-Pub 1994.
El-Naggar AK. DNA flow cytometric analysis in the assessment of soft tissue neoplams. Cancer Bulletin 45:24-28, 1993. e-Pub 1993.
Batsakis JG, Sneige N, El-Naggar AK. Flow cytometric (DNA content and S-phase fraction) analysis of breast cancer. Cancer 71:2151-2153, 1993. e-Pub 1993.

Review Articles

Shirima CA, Bleotu C, Spandidos DA, El-Naggar AK, Gradisteanu Pircalabioru G, Michalopoulos I. Epithelial‑derived head and neck squamous tumourigenesis (Review). Oncol Rep 52(4), 2024. e-Pub 2024. PMID: 39219259.
Williams MD, El-Naggar AK. Pathology and Differential Diagnosis of Anterior Skull Base Tumours. Adv Otorhinolaryngol 84:13-27, 2020. e-Pub 2020. PMID: 32731232.
El-Naggar AK. What Is New in the World Health Organization 2017 Histopathology Classification?. Curr Treat Options Oncol 18(7):43, 2017. e-Pub 2017. PMID: 28639231.
Salem A, Bell D, Sepesi B, Papadimitrakopoulou V, El-Naggar A, Moran CA, Kalhor N. Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: the MD Anderson Cancer Center experience and comprehensive review of the literature. Virchows Arch 470(6):619-626, 2017. e-Pub 2017. PMID: 28343305.
Cockerill CC, Daram S, El-Naggar AK, Hanna EY, Weber RS, Kupferman ME. Primary sarcomas of the salivary glands: case series and literature review. Head Neck 35(11):1551-7, 2013. e-Pub 2013. PMID: 23728801.
Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity!. Adv Anat Pathol 20(6):416-23, 2013. e-Pub 2013. PMID: 24113312.
Bell D, El-Naggar AK. Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications. Head Neck Pathol 7(1):23-7, 2013. e-Pub 2013. PMID: 23459841.
El-Naggar AK. Pathobiology of head and neck squamous tumorigenesis. Curr Cancer Drug Targets 7:606-612, 2007. e-Pub 2007. PMID: 18045065.
Yom SS, Rosenthal DI, El-Naggar AK, Kies MS, Hessel AC. Merkel cell carcinoma of the tongue and head and neck oral mucosal sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:761-768, 2006. e-Pub 2006. PMID: 16731397.
Koh JS, Trent J, Chen L, El-Naggar A, Hunt K, Pollock R, Zhang W. Gastrointestinal stromal tumors: overview of pathologic features, molecular biology, and therapy with imatinib mesylate. Histol Histopathol 19:565-574, 2004. e-Pub 2004. PMID: 15024716.
El-Naggar AK. Methods in molecular surgical pathology. Semin Diagn Pathol 19(2):56-71, 2002. e-Pub 2002. PMID: 12036282.
Williamson JD, Simmons BH, El-Naggar AK, Medeiros LJ. Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. Am J Clin Pathol 114:564-570, 2000. e-Pub 2000. PMID: 11026102.
Klijanienko J, Vielh P, Batsakis JD, el-Naggar AK, Jelen M, Piekarski JD. Salivary gland tumours. Monogr Clin Cytol 15:III-XII, 1-138, 2000. e-Pub 2000. PMID: 10879373.
el-Naggar AK, Klijanienko J. Advances in clinical investigations of salivary gland tumorigenesis. Ann Pathol 19(1):19-22, 1999. e-Pub 1999. PMID: 10320906.
Batsakis JG, Suarez P, El-Naggar AK. Proliferative verrucous leukoplakia and its related lesions. Oral Oncol 35:354-359, 1999. e-Pub 1999. PMID: 10645398.
Amin MB, de Peralta-Venturina MN, Ro JY, El-Naggar AK, Mackay B, Ordonez N, Mani A, Ayala A. Clear cell sarcoma of kidney in an adolescent and in young adults: a report of four cases with ultrastructural, immunohistochemical, and DNA flow cytometric analysis. Am J Surg Pathol 23:1455-1463, 1999. e-Pub 1999. PMID: 10584698.
Batsakis JG, Suarez P, El-Naggar AK. Mucosal melanomas of the head and neck. Ann Otol Rhinol Laryngol 107(7):626-30, 1998. e-Pub 1998. PMID: 9682861.
Suarez P, Batsakis JG, el-Naggar AK. Leukoplakia: still a gallimaufry or is progress being made?--A review. Adv Anat Pathol 5(3):137-55, 1998. e-Pub 1998. PMID: 9868520.
Soria JC, Vielh P, el-Naggar AK. Telomerase activity in cancer: a magic bullet or a mirage?. Adv Anat Pathol 5(2):86-94, 1998. e-Pub 1998. PMID: 9868515.
El-Naggar AK, Lovell M, Callender DL, Ordonez NG, Killary AM. Concurrent cytogenetic, interphase fluorescence in situ hybridization and DNA flow cytometric analyses of a carcinoma ex-pleomorphic adenoma of parotid gland. Cancer Genet Cytogenet 107:132-136, 1998. e-Pub 1998. PMID: 9844608.
Meterissian SH, Skibber JM, Giacco GG, El-Naggar AK, Hess KR, Rich TA. Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival. Surgery 121:479-87, 1997. e-Pub 1997. PMID: 9142144.
Austin JR, el-Naggar AK, Goepfert H. Thyroid cancers. II. Medullary, anaplastic, lymphoma, sarcoma, squamous cell. Otolaryngol Clin North Am 29(4):611-27, 1996. e-Pub 1996. PMID: 8844733.
Batsakis JG, El-Naggar AK. Cystic fibrosis and the sinonasal tract. Ann Otol Rhinol Laryngol 105(4):329-30, 1996. e-Pub 1996. PMID: 8604900.
Batsakis JG, El-Naggar AK, Luna MA. Thyroid gland ectopias. Ann Otol Rhinol Laryngol 105:996-1000, 1996. e-Pub 1996. PMID: 8973289.
Torres C, Ro JY, El-Naggar AK, Sim SJ, Weber RS, Ayala AG. Allergic fungal sinusitis: a clinicopathologic study of 16 cases. Hum Pathol 27:793-799, 1996. e-Pub 1996. PMID: 8760012.
Suarez PA, Batsakis JG, El-Naggar AK. Don't confuse dental soft tissues with odontogenic tumors. Ann Otol Rhinol Laryngol 105:490-494, 1996. e-Pub 1996. PMID: 8638904.
El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet 87:29-33, 1996. e-Pub 1996. PMID: 8646736.
Ligato S, El-Naggar AK, Cleary KR, Manning J. Extramedullary plasmacytoma mimicking primary colonic carcinoma in a patient with Crohn's disease. Case report and literature review. Arch Pathol Lab Med 120:279-282, 1996. e-Pub 1996. PMID: 8629905.
Batsakis JG, Mackay B, El-Naggar AK. Ewing's sarcoma and peripheral primitive neuroectodermal tumor: an interim report. Ann Otol Rhinol Laryngol 105:838-843, 1996. e-Pub 1996. PMID: 8865780.
Kemp BL, Batsakis JG, El-Naggar AK, Kotliar SN, Luna MA. Terminal duct adenocarcinomas of the parotid gland. J Laryngol Otol 109:466-468, 1995. e-Pub 1995. PMID: 7798011.
McGinnis M, Jacobs G, El-Naggar AK, Redline RW. Congenital peribronchial myofibroblastic tumor (so-called "congenital leiomyosarcoma"). A distinct neonatal lung lesion associated with nonimmune hydrops fetalis. Mod Pathol 6:487-492, 1993. e-Pub 1993. PMID: 8415597.
Batsakis JG, Sneige N, El-Naggar AK. Flow cytometric (DNA content and S-phase fraction) analysis of breast cancer. Cancer 71:2151-2153, 1993. e-Pub 1993. PMID: 8443764.
Zavala-Pompa A, Ro JY, El-Naggar AK, Ordonez NG, Amin MB, Pierce PD, Ayala AG. Primary carcinoid tumor of testis. Immunohistochemical, ultrastructural, and DNA flow cytometric study of three cases with a review of the literature. Cancer 72:1726-1732, 1993. e-Pub 1993. PMID: 7688660.
Batsakis JG, El-Naggar AK, Hicks MJ. Epithelial choristomas and teratomas of the tongue. Ann Otol Rhinol Laryngol 102:567-569, 1993. e-Pub 1993. PMID: 8333680.
Batsakis JG, Luna MA, el-Naggar AK. Nonsquamous carcinomas of the larynx. Ann Otol Rhinol Laryngol 101(12):1024-6, 1992. e-Pub 1992. PMID: 1463294.
Carrillo R, El-Naggar AK, Rodriguez-Peralto JL, Batsakis JG. Synovial sarcoma of the tongue: case report and review of the literature. J Oral Maxillofac Surg 50:904-906, 1992. e-Pub 1992. PMID: 1321899.
Rodriguez-Peralto JL, El-Naggar AK. Neurothekeoma of the oral cavity: case report and review of the literature. J Oral Maxillofac Surg 50:1224-1226, 1992. e-Pub 1992. PMID: 1403281.
Batsakis JG, Luna MA, El-Naggar AK. Basaloid monomorphic adenomas. Ann Otol Rhinol Laryngol 100:687-690, 1991. e-Pub 1991. PMID: 1872522.
Luna MA, Batsakis JG, El-Naggar AK. Salivary gland tumors in children. Ann Otol Rhinol Laryngol 100:869-871, 1991. e-Pub 1991. PMID: 1659302.
Ro JY, Dexeus FH, El-Naggar AK, Ayala AG. Testicular germ cell tumors. Clinically relevant pathologic findings. Pathol Annu 26:59-87, 1991. e-Pub 1991. PMID: 1650448.
Loose JH, el-Naggar AK, Ro JY, Huang WL, McMurtrey MJ, Ayala AG. Primary osteosarcoma of the lung. Report of two cases and review of the literature. J Thorac Cardiovasc Surg 100(6):867-873, 1990. e-Pub 1990. PMID: 2246908.
Batsakis JG, Luna MA, el-Naggar AK. Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol 99(11):929-933, 1990. e-Pub 1990. PMID: 2241022.
Batsakis JG, el-Naggar AK. Warthin's tumor. Ann Otol Rhinol Laryngol 99(7 Pt 1):588-591, 1990. e-Pub 1990. PMID: 2195965.
Ballance WA, Ro JY, el-Naggar AK, Grignon DJ, Ayala AG, Romsdahl MG. Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature. Am J Clin Pathol 93(6):795-801, 1990. e-Pub 1990. PMID: 2161180.
Batsakis JG, Luna MA, El-Naggar AK. Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. Ann Otol Rhinol Laryngol 99:1007-1009, 1990. e-Pub 1990. PMID: 2173892.
Shetlar DJ, Font RL, Ordonez N, El-Naggar AK, Boniuk M. A clinicopathologic study of three carcinoid tumors metastatic to the orbit. Immunohistochemical, ultrastructural, and DNA flow cytometric studies. Ophthalmology 97:257-264, 1990. e-Pub 1990. PMID: 2109298.
Batsakis JG, Regezi JA, Luna MA, El-Naggar AK. Histogenesis of salivary gland neoplasms: a postulate with prognostic implications. J Laryngol Otol 103:939-944, 1989. e-Pub 1989. PMID: 2685148.
El-Naggar AK, Batsakis JG, Kessler S. Benign metastatic mixed tumours or unrecognized salivary carcinomas?. J Laryngol Otol 102:810-812, 1988. e-Pub 1988. PMID: 2844940.

Editorials

Slootweg PJ, El-Naggar AK. World Health Organization 4th edition of head and neck tumor classification: insight into the consequential modifications. Virchows Arch 472(3):311-313, 2018. PMID: 29450648.
El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors' perspectives. Hum Pathol 66:10-12, 2017. PMID: 28583885.
El-Naggar AK, MD, PhD. What is New in the World Health Organization 2017 Histopathology Classificaiton? 18(7):43, 2017.
El-Naggar AK. HPV and Oropharyngeal Cancer Mystery: A glimmer of hope!. Oral Dis. PMID: 27095118.
Perrier ND, El-Naggar AK. Editorial: How clinically significant is minimal extrathyroidal extension in papillary thyroid cancer?. Surgery 159(1):22, 2016. PMID: 26518390.
William WN, El-Naggar AK. A novel target for oral cancer chemoprevention? Notch quite, yet . Cancer Prev Res (Phila) 8(4):262-5, 2015. PMID: 25712052.
El-Naggar AK, Kaye FJ, Stenman G. The 3rd Salivary Gland Tumor Workshop meeting report. Head Neck 35(8):1057-60, 2013. PMID: 23677839.
El-Naggar AK, Westra WH. p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency. Head Neck 34(4):459-61, 2012. PMID: 22180304.
Bell D, Roberts D, Karpowicz M, Hanna EY, Weber RS, El-Naggar AK. Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 12(7):569-73, 2011. PMID: 21785271.
Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma. Cancer Res 70(22):9143-52, 2010. PMID: 21062985.
Moskaluk CA, Frierson HF, El-Naggar AK, Futreal PA. C-kit gene mutations in adenoid cystic carcinoma are rare. Mod Pathol 23(6):905-6; author reply 906-7, 2010. PMID: 20514080.
Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK, Kaye FJ. Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions. Genes Chromosomes Cancer 49(1):59-69, 2010. PMID: 19827123.
El-Naggar AK, Kaye FJ, Shirazi Y, Gutkind JS, Forastiere AA. Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008. Head Neck 31(12):1542-3, 2009. PMID: 19890918.
Saintigny P, El-Naggar AK, Papadimitrakopoulou V, Ren H, Fan YH, Feng L, Lee JJ, Kim ES, Hong WK, Lippman SM, Mao L. DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia. Clin Cancer Res 15(19):6284-91, 2009. PMID: 19773378.
Bell D, Kupferman ME, Williams MD, Rashid A, El-Naggar AK. Primary colonic-type adenocarcinoma of the base of the tongue: a previously unreported phenotype. Hum Pathol. PMID: 19695679.
Ramdas L, Giri U, Ashorn CL, Coombes KR, El-Naggar A, Ang KK, Story MD. miRNA expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue. Head Neck. PMID: 19260130.
El-Naggar AK, Hopper C, Upile T, Jerjes W. Head & Neck Oncology: purpose, scope and goals-charting the future. Head Neck Oncol 1:1, 2009. PMID: 19284679.
Liu Z, Hou P, Ji M, Guan H, Studeman K, Jensen K, Vasko V, El-Naggar AK, Xing M. Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab 93:3106-3116, 2008. PMID: 18492751.
El-Naggar AK. Commentary: Clinicopathology features and long-term outcome of 293 phyllodes tumours of the breast. Breast Disease 19:144-145, 2008.
El-Naggar AK. Commentary: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19) associated TORC1-MAML2 gene fusion; Genes Chromosomes Cancer 2005;43:202-205. Adv Anat Pathology 13:80-82, 2006.
El-Naggar AK. Commentary: Prognostic significance of p27 (KIP1) expression in resected non-small cell lung cancers: Analysis in combination with expression of p16 (INK4A), pRB and p53. J Surg Oncol 81:184, 2002.
Batsakis JG, Medeiros JL, Luna MA, El-Naggar AK. Plasma cell dyscrasias and the head and neck. Ann Diagn Pathol 6:129-140, 2002.
El-Naggar AK. Commentary: CD34, CD117, and actin expression in phyllodes tumor of the breast. Breast Diseases 12:299, 2001.
El-Naggar AK. Commentary: Prognostic value of DNA cytometry in 281 premenopausal patients with lymph node negative breast carcinoma randomized in a control trial: Multivariate analysis with Ki-67 index, mitotic count, and microvessel density. Breast Diseases 12:179, 2001.
Ak E. Commentary: Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. Breast Diseases 12:178, 2001.
El-Naggar AK. Commentary: c-myc, p53 and bcl-2, apoptosis-related genes in infiltrating breast carcinomas: Evidence of a link between bck-2 protein over-expression and a lower risk of metastasis and death in operable patients. Breast Diseases 11:399, 2001.
El-Naggar AK. Commentary: Strong correlation between results of fluorescent in-situ hybridization and immunohistochemistry for the assessment of the ERBBS (HER-2/neu) gene status in breast carcinoma. Breast Diseases 12:299, 2001.
El-Naggar AK. Commentary: Different proliferative patterns characterize different pre-invasive breast lesions. Breast Diseases 11:52, 2000.
El-Naggar AK. Commentary: Predictive value of flow cytometry for metastatic potential in breast cancer. Breast Diseases 10:437, 2000.
El-Naggar AK. Commentary: Diagnostic molecular pathology comes of age. Adv Anat Pathol 6:324-346, 1999.
El-Naggar AK. Commentary: Cytogenetic abnormalities of primary breast carcinoma: Comparative analysis of fluorescence in-situ hybridization (FISH) and flow cytometry. Breast Disease 2:162, 1999.
El-Naggar AK, Benedict WF. Commentary: Retinoblastoma (RB1) gene product expression in breast carcinoma: Correlation with Ki-67 growth fraction and biopathological profile. Breast Disease 2:163, 1999.
El-Naggar AK, Klijanienko J. Advances in clinical investigations of salivary gland tumorigenesis. Ann Pathol 19:19-22, 1999.
El-Naggar AK. Commentary: Decreased apoptosis in non-involved tissue from cancer-containing breast. Breast Diseases 2:163, 1999.
Batsakis JG, El-Naggar AK. Commentary: Myoepithelium in salivary and mammary neoplasms is host-friendly. Adv Anat Pathol 6:218-226, 1999.
El-Naggar AK. Commentary: Mitosin (a new proliferation markers) correlates with clinical outcome in node-negative breast cancer. Breast Diseases 3:270-271, 1998.
El-Naggar AK, Vielh P. Commentary: Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites. Breast Diseases 8:346-347, 1998.
El-Naggar AK. Commentary: Apoptosis of BAX and bcl-2 expression in p53 immunopositive breast cancers. Breast Diseases 8:332, 1998.
El-Naggar AK. Commentary: Prognostic value of DNA ploidy using flow cytometry in 1,301 breast patients: Results of the prospective multicenter morphometric mammary carcinoma project. Breast Diseases 9:56-57, 1998.
El-Naggar AK. Commentary: Expression of Bcl-2 protein in human primary breast carcinomas and its correlation with multifocality, histopathological types and prognosis. Breast Diseases 9:63-64, 1998.
El-Naggar AK. Commentary: Correlation between the expression of apoptosis-related Bcl-2 and p53 oncoproteins and the carcinogenesis and progression of breast carcinoma. Breast Diseases 9:280, 1998.
El-Naggar AK. Commentary: Prognostic implications of different cell cycle analysis models of flow cytometric DNA histograms of 1,301 breast cancer patients; Results from the multicenter morphometric mammary carcinoma project (MMMCP). Breast Diseases 9:58-59, 1998.
El-Naggar AK. Commentary: Interlaboratory reproducibility of semiautomated cell cycle analysis of flow cytomeetric DNA-histograms obtained from fresh material of 1,295 breast cancer cases. Breast Disease 8:34-35, 1997.
El-Naggar AK. Commentary: Apoptosis loss and bcl-2 expression: Key determinants of lymph node metastases in T1 breast cancer. Breast Diseases 8:228-229, 1997.
El-Naggar AK. Commentary: Prognostic value of quantitative cytometry in a series of 415 T1T2/NoN1/M0 breast cancer patients: Preliminary report. Breast Disease:8135-8136, 1997.
El-Naggar AK. Commentary: DNA analysis and S-phase fraction determination by flow cytometric analysis of infiltrating lobular carcinoma of the breast. Breast Diseases 8:136-137, 1997.
Batsakis JG, El-Naggar AK. Ewing's sarcoma and primitive neuroectodermal tumors: Cytogenetic cynosures seeking a common histogenesis. Advances in Anatomic Pathology 4:207-220, 1997.
El-Naggar AK. Commentary: Imprinting in solid tumors: Cause of consequence?. Advances in Anatomic Pathology 3:173-175, 1997.
El-Naggar AK. Commentary: Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer. Breast Diseases 7:369-370, 1997.
Austin JR, El-Naggar AK, Goepfert H. Thyroid Cancers II: Medullary, Anaplastic, Lymphoma, Sarcoma, Squamous Cell. Ann Surg 29:611-627, 1996.
El-Naggar AK. Commentary: DNA aneuploidy in early breast cancer. Breast Diseases 3:265, 1996.
El-Naggar AK. Commentary: Different risk group in node-negative breast cancer: Prognostic value of cytophotometrically assessed DNA, morphometry and texture. Breast Diseases 7:161-162, 1996.
El-Naggar AK. Commentary: Bcl-2 expression in the spectrum of pre-invasive breast lesions. Breast Diseases 3:251-252, 1996.
El-Naggar AK. Commentary: Apoptosis suppressing protein bcl-2 is expressed in well-differentated breast carcinoma with favorable prognosis. Breast Diseases 7:160-161, 1996.
El-Naggar AK. Commentary: Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinicopathologic variables. Breast Diseases 3:252-253, 1996.
Klijanienko J, Janot F, deBraud F, Russo A, Pignon JP, El-naggar AK, Luboinski B, Cvitkovic E. Clinicopathological Grading in Head and Neck Squamosu Cell Carcinoma (HNSCC). A prospective analysis of 108 patients treated curatively. XVI International Cancer Congress:939-942, 1994.
El-Naggar AK. Commentary: DNA flow cytometric analysis and prognosis of axillary lymph node-negative breast carcinoma. Breast Diseases 4:27-28, 1993.
El-Naggar AK. DNA flow cytometry in the assessment of solid neoplasms. Ann Saudi Med 12(4):331-3, 1992. PMID: 17586988.
El-Naggar AK. Clinical relevance of flow cytometric analysis in cancer. Cancer Journal 5:321-327, 1992.
El-Naggar AK. Flow cytometry in the assessment of human solid neoplasms. Ann Saudi Med 12:331-333, 1992.
El-Naggar AK. Laryngeal neuroendocrine neoplasms. Victims of semantics. Path Lab Med 116:237-238, 1992.
Connelly JH, Robey-Cafferty SS, el-Naggar AK, Cleary KR. Exophytic signet-ring cell carcinoma of the colorectum. Arch Pathol Lab Med 115(2):134-136, 1991. PMID: 1847034.
el-Naggar AK, Batsakis JG. Carcinoid tumor of the larynx: A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 53(4):188-193, 1991. PMID: 1891251.

Book Chapters

El-Naggar AK. Molecular-based Lineage and Biological Markers of Neck Tumors. In: Diagnostic Procedures in Patients with Neck Masses. 2024. Springer Cham, 2024.
El-Naggar, AK. Lineage and Molecular Marker Integration in Diagnosis and Differential Diagnosis of Neck Tumors, 105-129, 2024.
Williams MD, El-Naggar AK. Head and Neck Pathology. In: Gattuso's Differential Diagnosis in Surgical Pathology. 4th, 129-217, 2022.
Bell D, Williams MD, El-Naggar AK. Thryoid and Parathyroid Tumors. In: Oncologic Surgical Pathology. 1. Springer Cham, 561-571, 2020.
Bell D, Williams MD, El-Naggar AK. Sinonasal and Skull Base Tumors. In: Oncological Surgical Pathology. 1. Springer Cham, 555-560, 2020.
Bell D, Williams MD, El-Naggar AK. Pathology of Head and Neck Tumors. In: Oncological Surgical Pathology. 1. Springer Cham, 581-688, 2020.
Bell D, Williams MD, El-Naggar AK. Tumors of the Salivary Gland. In: Oncological Surgical Pathology. 1. Springer Cham, 541-553, 2020.
El-Naggar AK. Molecular Diagnostics of Head and neck Cancer. In: Principles of Molecular Diagnostics and Personalized Cancer Medicine. 1. Lippincott Williams & Wilkins (LWW), 2013.
Williams MD, El-Naggar AK. Pathology of Tumor and Tumor-like Lesions of the Skull Base. In: Comprehensive Management of Skull Base Tumors. 1st. CRC Press, 43-62, 2009.
El-Naggar AK, Vielh P. Solid tumor DNA content analysis. In: Methods Molecular Biologic. Human Press, 355-370, 2004.
El-Naggar AK. Concurrent flow cytometric analysis of DNA and RNA. In: Methods Molecular Biologic. Methods Mol Biol. Human Press, 371-384, 2004.
El-Naggar AK. Metastasis of the larynx. In: In Diseases of the Larynx. Arnold, 2000.
El-Naggar AK. Diagnostic Surgical Pathology of the Head and Neck. In: . W.B. Saunders Co, 888, 2000.
Mao L, El-Naggar AK. Molecular changes in the multistage pathogenesis of head and neck cancer in molecular pathology of early cancer. Srivastava. S., Henson, D.E., and Gazdar . A. (ed), IOS press. . In: Amsterdam, 189-206, 1999.
Mao L, El-Naggar AK. Molecular changes in the multistage pathologenesis of head and neck cance. In: In Molecular Patholog of Early Cancer. IOS Press, 189-206, 1999.
El-Naggar AK. In head and neck recertification. In: Contemporary classification of salivary gland tumor. American Board of Otolaryngology. American Board of Otolaryngology, 1998.
Steck K, El-Naggar AK. In Flow Cytometry Protocols. In: Simultaneous DNA/RNA analysis of solid and hematoreticular malignancies. Methods Mol Biol. Humana Press 1997, 167-179, 1998.
Steck K, El-Naggar AK. In flow Cytometry Protocols. In: Solid tumors DNA solid tumors DNA ploidy analysis. Methods Mol Biol. Humana Press 1997, 181-195, 1998.
El-Naggar AK. Secondary Tumors of the Larynx. In: In Laryngeal Neoplasms, 1995.
El-Naggar AK. Genetics and Molecular Pathways of Primary and Metastatic Neck Tumors. In: Cytology and Pathology of Neck Tumors. Springer.

Letters to the Editor

Fakhry C, Zhang Q, Nguyen-Tan PF, Rosenthal D, El-Naggar AK, Garden AS, Soulieres D, Trotti A, Avizonis VN, Ridge JA, Harris J, Le QT, Gillison M. Reply to B. O'Sullivan et Al. J Clin Oncol 33: 1708-9, 2015.
El-Naggar AK. Letter to the Editor: Pleomorphic adenoma. Am J Surg Pathol 22: 772-773, 1999.
El-Naggar AK. Molecular alterations in salivary gland tumor. Surg Path 22: 1164-1165, 1998.
Ligato S, El-Naggar AK, Cleary KR, Manning J. Rectal plamacytoma (Letter to the Editor). Arch Pathol Lab Med 120: 1084-1085, 1996.
Ro JY, el-Naggar AK, Amin MB, Ayala AG. Inflammatory pseudotumor of the urinary bladder. Am J Surg Pathol 17: 1193-4, 1993.
Connelly JH, Robey-Cafferty SS, el-Naggar AK, Cleary KR. Exophytic signet-ring cell carcinoma of the colorectum. Arch Pathol Lab Med 115: 427, 1991.
Corkill, Sneige N, Fanning T, El-Naggar AK. Intracystic papillary carcinoma of the breast. Letter to the editor. . Am J Clin Pathol 95: 901, 1991.

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CV information above last modified March 06, 2026

Adel K. El-Naggar, M.D., Ph.D.

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Adel K. El-Naggar, M.D., Ph.D.

About Dr. Adel K. El-Naggar

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Education & Training

Degree-Granting Education

Postgraduate Training

Licenses & Certifications

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Other Professional Positions

Extramural Institutional Committee Activities

Editorial Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Regional Presentations

National Presentations

International Presentations

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Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Invited Articles

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Editorials

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