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      Amado J. Zurita-Saavedra Image

      Amado J. Zurita-Saavedra, M.D.

      Department of Genitourinary Medical Oncology, Division of Cancer Medicine

      Present Title & Affiliation

      Primary Appointment

      Professor, Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

      Dual/Joint/Adjunct Appointment

      Professor, Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

      Education & Training

      Degree-Granting Education

      2001Medical School, University of Barcelona, Barcelona, ES, Diploma of Advanced Studies (DEA), Pre PhD
      1993University of La Laguna, Santa Cruz de Tenerife, ES, MD

      Postgraduate Training

      2006-2007Clinical Fellowship, Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
      2001-2006Postdoctoral Fellowship, Vascular Targeting & Angiogenesis in Genitourinary Malignancies, The University of Texas MD Anderson Cancer Center; Departments of Genitourinary Medical Oncology and Cancer Biology, Houston, Texas
      2001-2001Post-doctoral course, Advances in Molecular Biology, University of Barcelona; Biochemistry Unit, Barcelona
      1998-2000Pre PhD path, General Pathophysiology of Disease, University of Barcelona, Barcelona
      1996-2000Clinical Fellowship, Medical Oncology, University of Barcelona, Barcelona
      1994-1995Post-doctoral course, Statistical Methods in Health Sciences, Autonomous University of Barcelona, Barcelona

      Licenses & Certifications

      2018American Board of Internal Medicine, Oncology
      2017American Board of Internal Medicine, Internal Medicine
      2016DEA - Practitioner
      2015DPS Controlled Substance Registration
      2010Texas Medical Board
      2009TX
      2008TX
      2007TX
      2006TX
      2004Educational Commission for Foreign Medical Graduates (ECFMG)
      2000Spanish Ministry of Health

      Experience & Service

      Faculty Academic Appointments

      Associate Professor, Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2022

      Assistant Professor, Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2015

      Clinical Fellow, Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2007

      Postdoctoral Fellow, Genitourinary Medical Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 - 2006

      Instructor, Catalan Institute of Oncology, Barcelona, 2000 - 2001

      Other Professional Positions

      Department Protocol Reviewer for CRC, University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - Present

      Extramural Institutional Committee Activities

      Member, Data and Biospecimen Access Committee (DBAC, The University of Texas MD Anderson Cancer Center, 2023 - Present

      Member, Credentials Committee, The University of Texas MD Anderson Cancer Center, 2020 - 2023

      Member, Clinical Ethics Consultation Committee, The University of Texas MD Anderson Cancer Center, 2017 - Present

      Reviewer, Institutional Research Grant Program (IRG), The University of Texas MD Anderson Cancer Center, 2010 - Present

      Member, Institutional Review Board (IRB5), The University of Texas MD Anderson Cancer Center, 2010 - 2024

      Reviewer, Clinical Research Committee (CRC4), The University of Texas MD Anderson Cancer Center, 2008 - 2012

      Editorial Activities

      Program Reviewer, Kidney Cancer Research Program, 2018 - Present

      Editorial Advisory Board Member, Clinical Immunology, Endocrine & Metabolic Drugs, 2016 - Present

      Honors & Awards

      2022NCCN Pfizer
      2017 - 2023Multi-Year Award, The University of Texas MD Anderson Cancer Center
      2010PCF Young Investigator Award, Prostate Cancer Foundation, Washington, DC
      2007ASCO Young Investigators Award, American Society of Clinical Oncology
      2006K12 Program Award, The University of Texas Medical School at Houston
      2006Participant in AACR/ASCO "Methods in Clinical Cancer Research" Workshop, Vail, CO
      2002 - 2005Research Training Award, Instituto de Salud Carlos III, Department of Health, Spain
      2000Best Presentation, Academy of Medical Sciences of Catalonia and the Balearics, Spain

      Professional Memberships

      Cancer Survivorship Committee

      2024 - Present

      European Association of Cancer Research (EACR)

      2020 - Present

      Sociedad Española de Oncología Médica (SEOM)

      2007 - Present

      American Society of Clinical Oncology

      2004 - Present

      American Association for Cancer Research

      2004 - Present

      European Society of Medical Oncology (ESMO)

      2003 - Present

      Selected Presentations & Talks

      Local Presentations

      1. 2016. Liquid Biopsies: Are We There Yet?. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
      2. 2011. Measurement of the Circulating Microenvironment. Conference. 1st Annual Kidney CA Symposium Renal MRP. Houston, TX, US.

      National Presentations

      1. 2023. Updates In The Therapy For RCC. Invited. AHOMPR. Ponce, PR, US.
      2. 2022. Dr. Zurita-Saavedra on Augmenting Therapy Earlier in Prostate Cancer Treatment Journey. Conference. OncLive TV, US.
      3. 2018. Newly Diagnosed Metastatic Prostate Carcinoma: Has The Paradigm Changed?. Invited. CancerNet, LLC. Houston, TX, US.
      4. 2018. Updates in the Management of Genitourinary Oncology. Invited. 12th Annual Mid-America Cancer Symposium. Wichita, KS, US.
      5. 2017. A Clinically Feasible Strategy to Concurrently Profile Prostate Cancer in Circulation and Bone Using High-Definition Single Cell Analysis. Invited. Cambridge Healthtech Institute. San Francisco, CA, US.
      6. 2017. Circulating Tumor Cells in Clinical Trials: Strategies and Current Status. Invited. Cambridge Healthtech Institute. San Francisco, CA, US.
      7. 2015. State of the Art Lecture Circulating Biomarkers in Genitourinary Cancers. Invited. 10th Urologic Oncology: Advances in Clinical Practice. Houston, TX, US.
      8. 2014. High-Definition Single Cell Analysis (HD-SCA) of Prostate Cancer (PCa) Cells in Matched Marrow and Blood from Patients. Conference. 21st Annual PCF Scientific Retreat. Carlsbad, CA, US.
      9. 2013. Microenvironment Targeting of Angiogenesis. Conference. Prouts Neck Presenters 2.0 Meeting. Lake Tahoe, NV, US.
      10. 2012. A Novel Platform for Detection of Epithelial-Mesenchymal Transition in Circulating Prostate Cancer. Invited. 19th PCF Scientific Retreat. San Diego, CA, US.
      11. 2011. Young Investigator Meeting. Conference. Prostate Cancer Foundation. Incline Village, NV, US.
      12. 2009. Young Investigator Meeting. Conference. Prostate Cancer Foundation. Incline Village, NV, US.
      13. 2009. Kidney Cancer Associates Annual Meeting. Conference. Dana Farber/ Harvard Cancer Center. Chicago, IL, US.
      14. 2009. Sunitinib (SU) Affects Specific Peripheral Blood Mononuclear Cell Subpopulations (PBMC) and Circulating Endothelial Cells (CEC) in Patients (pts) with Neuroendocrine Tumors (NET): Correlation with Plasma Proteins and Pharmacokinetics. Conference. 2009 Annual AACR Meeting. Denver, CO, US.
      15. 2009. Circulating Endothelial Cells (CEC) and Progenitors (CEP) and VEGFR-1-Expressing Monocytes as Biomarkers for Patients (pts) with Renal Cell Carcinoma (RCC). Conference. 2009 Annual AACR Meeting. Denver, CO, US.
      16. 2008. Young Investigators Meeting. Conference. Prostate Cancer Foundation. Incline Village, NV, US.
      17. 2008. Atkins Renal Cancer Conference. Invited. Innovations and Challenges in Renal Cancer Third Cambridge Conference. Cambridge, MA, US.
      18. 2008. Androgen Receptor-Negative Human Prostate Cancer Cells Induce Osteogenesis Through FGF9-Mediated Mechanisms. Conference. 2008 Annual AACR Meeting. San Diego, CA, US.
      19. 2008. Molecular, Electron-Microscopic, Inter-Laboratory and Clinical Validation of a Novel Standardized Flow Cytometric Method for the Enumeration of Circulating Endothelial Cells and Progenitors. Conference. 2008 Annual AACR Meeting. San Diego, CA, US.
      20. 2008. Cytokine and Angiogenic Factor (CAF) Profiling for Prediction of Outcome to First Line Sorafenib (SR) Versus SR Plus Low-Dose Interferon-α (IFNα) in Patients with Advanced Renal Cell Carcinoma (mRCC). Conference. 2008 Annual AACR Meeting. San Diego, CA, US.
      21. 2003. Therapeutic targets in Prostate Cancer and Bone Metastasis Identified by In Vivo Phage Display in Patients. Invited. 11th SPORE Investigators’ Workshop. Baltimore, MD, US.

      International Presentations

      1. 2023. Updates In The Prostate Cancer. Invited. HIKMA Cancer Network, JO.
      2. 2023. Updates in Prostate Cancer. Invited. Janssen Oncology Colombia. Cartagena, CO.
      3. 2022. updates in prostate cancer: mCRPC and mHSPC. Invited. Hikma Cancer Network, JO.
      4. 2018. Hormone-sensitive prostate cancer. BQ recurrence not metastasic. Patient selection and treatment. Invited. SOGUG. Madrid, ES.
      5. 2018. Developing Integrative Liquid Biopsies in prostate Cancer. Invited. Del Colegio Mexicano Para La Investigacion Del Cancer. Puebla, MX.
      6. 2017. Novel Treatment Options for Prostate Cancer Presenting with Metastasis. Invited. Janssen. Cartagena, CO.
      7. 2016. Biomarker in Kidney Cancer & Biomarkers in Prostate Cancer. Invited. Simposio de Urología Oncológica. Bogotá, US.
      8. 2012. Prostate Cancer Symposium. Updated on hormonal manipulation and novel alernative treatment options for recurrent prostate cancer. Invited. XXII Anniversary Instituto Jaliscience de Cancerologia. Guadalajara, MX.
      9. 2012. A Novel Platform for Detection of Epithelial-Mesechymal Transition (EMT) in Circulating Prostate Cancer Cells. Conference. Advance in Circulating Tumor Cells(ACTC) from Basic Research to Clinical Practice. Athens, GR.
      10. 2007. A Phase I/II Study of Sunitinib in Combination with Docetaxel (dcx) and Prednisone (pdn) in Patients with Metastatic Castrate-Resistant Prostate Cancer (mcRPC). Conference. ECCO 14. Barcelona, ES.
      11. 2007. New Therapeutic Strategies in Prostate Cancer. Conference. 3rd International Symposium on Translational Oncology. Barcelona, ES.
      12. 1999. VII Curso Teórico-Práctico sobre Progresos en Oncología Médica. Conference. Update on Therapeutic Strategies in Gastric Carcinoma. Madrid, ES.

      Formal Peers

      1. 2015. High-Definition Single Cell Analysis (HD-SCA) of Prostate Cancer (PCa) Cells in Matched Marrow and Blood from Patients. Invited. Los Angeles, CA, US.
      2. 2008. 4th Annual Innovations & Challenges in Renal Cancer. Invited. Cambridge, MA, US.
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      Grant & Contract Support

      Date: 2026 - Present
      Title:UT Sub: Optimal management of metastatic prostate cancer with patient-specific digital twins
      Funding Source:Department of War
      Role:Co-I
      ID:FP00031526
      Date: 2026 - 2029
      Title:Digital twins for personalized, predictive management of advanced prostate cancer at metastatic stage
      Funding Source:TAMEST/ Lyda Hill Foundation
      Role:Co-PI
      ID:FP00026620
      Date: 2025 - 2028
      Title:An Integrated Combinatorial Strategy for Intensification of Radioligand Therapy in Prostate Cancer
      Funding Source:Individual Investigator Research Awards
      Role:Co-PI
      ID:RP260228
      Date: 2025 - 2026
      Title:Computational Imaging Based Forecasting of Growth, Disemination, and Treatment Response in High-Risk Metastatic Prostate Cancer
      Funding Source:Joint Center for Computational Oncology (JCCO) (UTMDACC Institute for Data Science in Oncology, UT Austin Oden Institute for Computational Engineering and Sciences & Texas Advanced Computing Center) Pilot Program Grant Program
      Role:PI
      Date: 2025 - 2028
      Title:Presurgical Phase II Study of Talazoparib in Combination with Enzalutamide in de novo metastaic to Lymph Node Prostate Cancer
      Funding Source:PRIME
      Role:PI
      Date: 2025 - 2030
      Title:Decoding the Copy Number Substructure of Human Cancers with Single Cell and Spatial Genomics
      Funding Source:NIH / NCI
      Role:PI
      ID:R01 CA292076-01A1
      Date: 2025 - 2030
      Title:Targeted Suppression of Microtubule Dynamics for Treatment of Metastatic Castration-Resistant Prostate Cancer
      Funding Source:UT Health / NIH
      Role:PI
      ID:R01 CA298343-01A1
      Date: 2024 - 2025
      Title:Priority Project 1: Targeting Myeloid Cells in Lethal Prostate Cancer to Overcome the Immunosuppressive Microenvironment
      Funding Source:MD Anderson Moon Shot/Prostate Cancer Moon Shoot
      Role:Collaborator
      Date: 2024 - 2031
      Title:A Phase 2/3, randomized, open-label, multicenter study to evaluate the safety and efficacy of FPI-2265 (225Ac-PSMA-I&T) in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), previously treated with 177Lu-PSMA radioligand therapy (RLT)
      Funding Source:Fusion Pharma
      Role:PI
      ID:2024-0209
      Date: 2023 - 2028
      Title:Revisiting Antiangiogenic Therapy to Target Hormone Sensitive Prostate Cancer Metabolism
      Funding Source:NIH/NCI
      Role:Co-PI
      ID:RO1 CA275138-01A1
      Date: 2022 - 2025
      Title:Revisiting antiangiogenic therapy to target prostate cancer metabolism
      Funding Source:Department of Defense (DOD)
      Role:Co-PI
      ID:PC210046
      Date: 2022 - 2023
      Title:Priority Project 1: Investing Therapy Resistance and Metastatic in the Prostate Cancer Microenvironment (Navin/Zurita)
      Funding Source:MD Anderson Moon Shot/Prostate Cancer Moon Shoot
      Role:Co-Leader
      Date: 2022 - 2025
      Title:Revisiting Antiangiogenic Therapy to Target Prostate Cancer Metabolism
      Funding Source:DOD
      Role:Partnering PI
      ID:PC210046P1
      Date: 2022 - 2029
      Title:A Multi-Center, Open-Label, Randomized Phase 1/2 Study of Copper Cu 64 PSMA I&T Injection in Patients with Histologically Proven Metastatic Prostate Cancer
      Funding Source:Curium US LLC
      Role:PI
      ID:2021-1051
      Date: 2022 - 2025
      Title:Potentiation of prostate cancer immunotherapy by adipose stroma targeting
      Funding Source:CPRIT
      Role:Subcontract PI
      Date: 2021 - 2028
      Title:A Phase 1, Dose-escalation Study to Evaluate Safety and Tolerability of Belzutifan (MK-6482) in Participants with Advanced Clear Cell Renal Cell Carcinoma (ccRCC)
      Funding Source:Merck & Co
      Role:PI
      ID:2021-0128
      Date: 2021 - 2024
      Title:Glutaminase inhibition disrupts mitochondrial metabolism and induces immune checkpoint protein expression in prostate cancer
      Funding Source:Department of Defense (DOD)
      Role:Co-I
      ID:PC200652
      Date: 2021 - 2028
      Title:Phase III Study of [18F]PSMA-1007 Positron Emission Tomography for the Detection of Prostate Cancer Lesions in Patients with Biochemical Recurrence after Previous Definitive Treatment for Localized Prostate Cancer
      Funding Source:Pharmtrace Klinische Entwicklung GMBH
      Role:PI
      ID:2020-1292
      Date: 2021 - 2026
      Title:Mitochondrial metabolism affects immune checkpoint proteins in prostate cancer
      Funding Source:NIH
      Role:Co-I
      ID:1 R01 CA258701
      Date: 2020 - 2023
      Title:Leveraging the AR-DDR interaction in de-novo metastatic prostate cancer towards precision combination therapies with PARP inhibitors
      Funding Source:Ayuda Lab Asociación Española Contra el Cáncer 2020
      Role:Co-I
      Date: 2020 - 2023
      Title:Anti-Androgens Treatment Enhances Cytotoxicity of Oxidative-Phosphorylation Inhibitors Against Castration Resistant Prostate Cancer
      Funding Source:Department of Defense (DOD)
      Role:Co-I
      ID:W81XWH2010306
      Date: 2020 - 2021
      Title:Prostate Cancer Moon Shot Priority Project 3: Delineating longitudinal therapeutic resistance and metastatic progression in lethal prostate cancer using single cell and plasma genome sequencing approaches (Navin/Zurita)
      Funding Source:MD Anderson Moon Shot Program
      Role:Co-I
      Date: 2020 - 2023
      Title:Targeting cancer-associated fibroblasts to potentiate chemotherapy and immunotherapy
      Funding Source:UT Health Science Center
      Role:Subcontract PI
      Date: 2020 - 2027
      Title:A Phase 2, Multi-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of IPI-549 Administered in Combination with Front-line Treatment Regimens in Patients with Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell Carcinoma
      Funding Source:Infinity Pharmaceuticals Inc
      Role:PI
      ID:2019-0729
      Date: 2018 - 2019
      Title:Flagship 1: Development of Mechanism-based Combination Therapies for Castration-Resistant Prostate Cancer
      Funding Source:MD Anderson Cancer Moon Shot Program
      Role:Investigator
      ID:Prostate Moon Shot
      Date: 2017 - 2018
      Title:Flagship Project 1: Optimizing AR signaling inhibition and addressing mechanisms of resistance
      Funding Source:MD Anderson Prostate Cancer Moon Shot
      Role:Co-I
      ID:Prostate Cancer Moon Shot
      Date: 2017 - 2022
      Title:The Wnt Canonical Pathway and Osteoblastic Progression of Prostate Cancer in Bone
      Funding Source:NIH/NCI
      Role:Co-I
      Date: 2017 - 2022
      Title:PI3K Gamma Inhibition in Combination with Anti-Angiogenics and/or Immunotherapy in Renal Cell and Lung Carcinoma Models
      Funding Source:Infinity Pharmaceuticals Inc
      Role:PI
      Date: 2016 - 2019
      Title:Delineating Clonal Evolution in Prostate Cancer Metastatic to Lymph Nodes by Single Cell Sequencing
      Funding Source:Department of Defense (DOD)
      Role:Co-I
      ID:PC150832
      Date: 2015 - 2016
      Title:Flagship Project 1: Optimizing Androgen Signaling Inhibition to Transition from a Treatment to Curative Paradigm
      Funding Source:MD Anderson Moon Shot Program
      Role:Co-I
      ID:Prostate Cancer Moon Shot
      Date: 2014 - 2014
      Title:PCF-Movember Gap
      Funding Source:Prostate Cancer Foundation
      Role:PI
      Date: 2013 - 2015
      Title:Modulation of Anti-Angiogenic Resistance in Renal Cell Carcinoma
      Funding Source:Kidney Cancer Pilot Project Program
      Role:PI
      Date: 2013 - 2016
      Title:8-Chloroadenosine Inhibits Growth of Renal Cell Cancer through AMPK Activation and MTOR Pathway Suppression
      Funding Source:MDACC Institutional Research Grant
      Role:PI
      Date: 2011 - 2016
      Title:Therapeutic Molecular Targeting of the Prostate Cancer-Bone Microenvironment: A Multi-Investigator, Multi-Institutional Collaborative Program Project
      Funding Source:Cancer Prevention & Research Institute of Texas (CPRIT)
      Role:Collaborator
      ID:RP110521
      Date: 2010 - 2013
      Title:Clinical applications for cadherin-11 in prostate cancer bone metastasis
      Funding Source:Prostate Cancer Foundation
      Role:2010 Young Investigator Award
      Date: 2009 - 2011
      Title:Circulating osteoblast lineage cells as a new biomarker in prostate cancer bone metastasis
      Funding Source:MDACC Institutional Research Grant
      Role:PI
      Date: 2008 - 2013
      Title:Circulating biomarkers of antiangiogenic therapy: tumor vs. host dependence and determinants of resistance
      Funding Source:AstraZeneca-MD Anderson Strategic Alliance
      Role:PI
      Date: 2007 - 2009
      Title:Role of OB-Cadherin in Prostate Cancer Bone Metastasis
      Funding Source:American Society of Clinical Oncology
      Role:PI
      ID:Young Investigator Award
      Date: 2007 - 2008
      Title:Osteoblast Cadherin (OB-Cadherin) for the Prediction and Prevention of Bone Metastasis
      Funding Source:Prostate Cancer Foundation
      Role:Co-I
      Date: 2006 - 2011
      Title:Developing Osteoblast Cadherin (Ob-Cadherin) as a biomarker and therapeutic target in prostate cancer bone metastasis
      Funding Source:NIH/NCRR
      Role:K12 Scholar
      ID:KL2 RR024149
      Date: 2006 - 2011
      Title:A Phase II Neoadjuvant Trial of Sunitinib Malate (SU011248) Plus Hormonal Ablation for Patients Who Have High Risk Localized Prostate Cancer and Will Undergo Prostatectomy
      Funding Source:Pfizer
      Role:PI
      Title:Phase 2 Study of AMG 208 Evaluating the Tumor Microenvironment in Metastatic Castration-Resistant Prostate Cancer
      Funding Source:Amgen
      Role:PI

      Selected Publications

      Peer-Reviewed Articles

      1. Chapin, BF, Smaldone, MC, Zurita-Saavedra, A, Wang, RJ, Cooperberg, MR, Gleave, ME, Delacroix, SE, Davis, JW, Pettaway, CA, Pisters, LL, Adibi, M, Chery, LJ, Papadopoulos, JN, Ward, JF, Gregg, JR, Navai, N, Corn, P, Subudhi, SK, Logothetis, CJ, Kuban, DA, Nguyen, Q, Tang, C, Choi, S, Hoffman, K, Lozano, M, Elsheftawi, M, Achim, M, Zhao, Y, Ramesh, N, Sei, E, Navin, N, Nogueras Gonzalez, G, Wang, X, Zhu, K, Troncoso, P, Zhang, M, McGuire, SE, Aparicio, A. A Phase 2, Randomized, Controlled Trial of Best Systemic Therapy Versus Best Systemic Therapy with Definitive Treatment of the Primary Tumor in Metastatic Prostate Cancer. European urology 90(2):125-136, 2026. e-Pub 2026. PMID: 41833492.
      2. Subramani, E, Pilie, PG, Slack Tidwell, RS, Viscuse, PV, Kuang, X, Kandasamy, T, Awad, D, Han, JJ, Huang, L, Peterson, CB, Zurita-Saavedra, A, Subudhi, SK, Corn, P, Soundararajan, R, Shepherd, P, Piyarathna, B, Putluri, V, Putluri, N, Sreekumar, A, Wang, YZ, Zoubeidi, A, Mahmud, I, Martinez, SA, Tan, L, Lorenzi, PL, Basu, S, Jindal, S, Sharma, P, Logothetis, CJ, Thompson, T, Frigo, DE, Aparicio, A. Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers. iScience 29(6), 2026. e-Pub 2026. PMID: 42291217.
      3. Tang, C, Seo, A, Sherry, AD, Yang, P, Kobayashi, K, Sircar, K, Genovese, G, Jonasch, E, Shah, AY, Zurita-Saavedra, A, Kovitz, CA, Campbell, M, Su, S, Yang, J, Ratzel, S, Acevedo, A, LaBella, ML, Battey, CJ, Steiner, C, Ascione, L, Liu, X, Hannan, R, Shapiro, DD, Choueiri, TK, Tannir, NM, Msaouel, P, Xu, W. KIM-1 and Circulating Tumor DNA Are Prognostic Markers for Oligometastatic Clear-cell Renal Cell Carcinoma. European urology 89(4):313-317, 2026. e-Pub 2026. PMID: 41765697.
      4. Dizman, N, Doshi, SD, Ocejo, A, Knezevic, A, Moura Nascimento Santos, MJ, Cornish, AE, Zurita-Saavedra, A, Campbell, M, Kotecha, RR, Jonasch, E, Shah, NJ, Alhalabi, O, Carlo, M, Shah, AY, Feldman, DR, Msaouel, P, Motzer, RJ, Tannir, NM, Voss, MH, Hahn, AW. Sarcomatoid versus rhabdoid dedifferentiation and histologic grade-specific outcomes in metastatic clear cell renal cell carcinoma (mccRCC). Journal of Clinical Oncology 44:456, 2026. e-Pub 2026.
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      59. Syed S, Basourakos SP, Ali FS, Garcia JL, Zurita-Saavedra A, Gong Z. A Limited-Versus-Extensive Staging Strategy for Small Cell Prostate Cancer. Am J Clin Oncol 43(2):87-93, 2020. e-Pub 2020. PMID: 31764016.
      60. Efstathiou E, Davis JW, Pisters L, Li W, Wen S, McMullin RP, Gormley M, Ricci D, Titus M, Hoang A, Zurita AJ, Tran N, Peng W, Kheoh T, Molina A, Troncoso P, Logothetis CJ. Clinical and Biological Characterisation of Localised High-risk Prostate Cancer: Results of a Randomised Preoperative Study of a Luteinising Hormone-releasing Hormone Agonist with or Without Abiraterone Acetate plus Prednisone. Eur Urol 76(4):418-424, 2019. e-Pub 2019. PMID: 31176622.
      61. Corn PG, Heath EI, Zurita A, Ramesh N, Xiao L, Sei E, Li-Ning-Tapia E, Tu SM, Subudhi SK, Wang J, Wang X, Efstathiou E, Thompson TC, Troncoso P, Navin N, Logothetis CJ, Aparicio AM. Cabazitaxel plus carboplatin for the treatment of men with metastatic castration-resistant prostate cancers: a randomised, open-label, phase 1-2 trial. Lancet Oncol, 2019. e-Pub 2019. PMID: 31515154.
      62. Heath E, Heilbrun L, Mannuel H, Liu G, Lara P, Monk JP, Flaig T, Zurita A, Mack P, Vaishampayan U, Stella P, Smith D, Bolton S, Hussain A, Al-Janadi A, Silbiger D, Usman M, Ivy SP. Phase II, Multicenter, Randomized Trial of Docetaxel plus Prednisone with or Without Cediranib in Men with Chemotherapy-Naive Metastatic Castrate-Resistant Prostate Cancer. Oncologist 24(9):1149-e807, 2019. e-Pub 2019. PMID: 31152080.
      63. Shah AY, Kotecha RR, Lemke EA, Chandramohan A, Chaim JL, Msaouel P, Xiao L, Gao J, Campbell MT, Zurita AJ, Wang J, Corn PG, Jonasch E, Motzer RJ, Sharma P, Voss MH, Tannir NM. Outcomes of patients with metastatic clear-cell renal cell carcinoma treated with second-line VEGFR-TKI after first-line immune checkpoint inhibitors. Eur J Cancer 114:67-75, 2019. e-Pub 2019. PMID: 31075726.
      64. Kim ST, Bittar M, Kim HJ, Neelapu SS, Zurita AJ, Nurieva R, Suarez-Almazor ME. Recurrent pseudogout after therapy with immune checkpoint inhibitors: a case report with immunoprofiling of synovial fluid at each flare. J Immunother Cancer 7(1):126, 2019. e-Pub 2019. PMID: 31088575.
      65. Gerdtsson E, Pore M, Thiele JA, Gerdtsson AS, Malihi PD, Nevarez R, Kolatkar A, Velasco CR, Wix S, Singh M, Carlsson A, Zurita AJ, Logothetis C, Merchant AA, Hicks J, Kuhn P. Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry. Converg Sci Phys Oncol 4(1), 2018. e-Pub 2018. PMID: 30906572.
      66. Bilen MA, Hess KR, Subudhi SK, Aparicio A, Kim J, Zurita-Saavedra AJ, Araujo JC, Corn PG, Stover J, Lin SH, Logothetis CJ, Tu SM. Clinical predictors of survival in patients with castration-resistant prostate cancer receiving sipuleucel-T cellular immunotherapy. Cancer Chemother Pharmacol 80(3):583-589, 2017. e-Pub 2017. PMID: 28730293.
      67. Zurita AJ, Gagnon RC, Liu Y, Tran HT, Figlin RA, Hutson TE, D'Amelio AM, Sternberg CN, Pandite LN, Heymach JV. Integrating cytokines and angiogenic factors and tumour bulk with selected clinical criteria improves determination of prognosis in advanced renal cell carcinoma. Br J Cancer 117(4):478-484, 2017. e-Pub 2017. PMID: 28683470.
      68. Msaouel P, Zurita AJ, Huang S, Jonasch E, Tannir NM. Plasma cytokine and angiogenic factors associated with prognosis and therapeutic response to sunitinib vs everolimus in advanced non-clear cell renal cell carcinoma. Oncotarget 8(26):42149-42158, 2017. e-Pub 2017. PMID: 28178674.
      69. Jonasch E, Hasanov E, Corn P, Moss T, Shaw K, Stovall S, Marcott V, Gan B, Bird S, Wang X, Do K, Altamirano P, Zurita A, Doyle L, Lara P, Tannir NM. A Randomized Phase 2 Study of MK-2206 versus Everolimus in Refractory Renal Cell Carcinoma. Ann Oncol 28(4):804-808, 2017. e-Pub 2017. PMID: 28049139.
      70. Kuhn P, Carlsson A, Luttgen MS, Dizon KK, Troncoso P, Corn P, Kolatkar A, Hicks JB, Logothetis C, Zurita AJ. Paired high-content analysis of prostate cancer cells in bone marrow and blood characterizes increased androgen receptor expression in tumor cell clusters. Clin Cancer Res 23(7):1722-1732, 2017. e-Pub 2017. PMID: 27702818.
      71. Subudhi SK, Aparicio A, Gao J, Zurita AJ, Araujo JC, Logothetis CJ, Tahir SA, Korivi BR, Slack RS, Vence L, Emerson RO, Yusko E, Vignali M, Robins HS, Sun J, Allison JP, Sharma P. Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities. Proc Natl Acad Sci U S A 113(42):11919-11924, 2016. e-Pub 2016. PMID: 27698113.
      72. Dayyani F, Zurita AJ, Nogueras-González GM, Slack R, Millikan RE, Araujo JC, Gallick GE, Logothetis CJ, Corn PG. The combination of serum insulin, osteopontin, and hepatocyte growth factor predicts time to castration-resistant progression in androgen dependent metastatic prostate cancer- an exploratory study. BMC Cancer 16:721, 2016. e-Pub 2016. PMID: 27599544.
      73. Cardó-Vila M, Marchiò S, Sato M, Staquicini FI, Smith TL, Bronk JK, Yin G, Zurita AJ, Sun M, Behrens C, Sidman RL, Lee JJ, Hong WK, Wistuba II, Arap W, Pasqualini R. Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity. Am J Pathol 186(8):2162-70, 2016. e-Pub 2016. PMID: 27317903.
      74. McKay RR, Zurita AJ, Werner L, Bruce JY, Carducci MA, Stein MN, Heath EI, Hussain A, Tran HT, Sweeney CJ, Ross RW, Kantoff PW, Slovin SF, Taplin ME. A Randomized Phase II Trial of Short-Course Androgen Deprivation Therapy With or Without Bevacizumab for Patients With Recurrent Prostate Cancer After Definitive Local Therapy. J Clin Oncol 34(16):1913-20, 2016. e-Pub 2016. PMID: 27044933.
      75. Williams SB, Davis JW, Wang X, Achim MF, Zurita-Saavedra A, Matin SF, Pisters LL, Ward JF, Pettaway CA, Chapin BF. Neoadjuvant Systemic Therapy Before Radical Prostatectomy in High-Risk Prostate Cancer Does Not Increase Surgical Morbidity: Contemporary Results Using the Clavien System. Clin Genitourin Cancer 14(2):130-8, 2016. e-Pub 2016. PMID: 26558524.
      76. Bilen MA, Zurita AJ, Ilias-Khan NA, Chen HC, Wang X, Kearney AY, Hodges S, Jonasch E, Huang S, Khakoo AY, Tannir NM. Hypertension and circulating cytokines and angiogenic factors in patients with advanced non-clear cell renal cell carcinoma treated with sunitinib: results from a phase II trial. Oncologist 20(10):1140-8, 2015. e-Pub 2015. PMID: 26306901.
      77. Liu XD, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Zhang X, Bai S, German P, Tamboli P, Rao P, Karam JA, Wood C, Matin S, Zurita A, Bex A, Griffioen AW, Gao J, Sharma P, Tannir N, Sircar K, Jonasch E. Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma. Cancer Immunol Res 3(9):1017-29, 2015. e-Pub 2015. PMID: 26014097.
      78. Zurita AJ, Pisters LL, Wang X, Troncoso P, Dieringer P, Ward JF, Davis JW, Pettaway CA, Logothetis CJ, Pagliaro LC. Integrating chemohormonal therapy and surgery in known or suspected lymph node metastatic prostate cancer. Prostate Cancer Prostatic Dis 18(3):276-80, 2015. e-Pub 2015. PMID: 26171883.
      79. Karjalainen K, Jaalouk DE, Bueso-Ramos C, Bover L, Sun Y, Kuniyasu A, Driessen WH, Cardó-Vila M, Rietz C, Zurita AJ, O'Brien S, Kantarjian HM, Cortes JE, Calin GA, Koivunen E, Arap W, Pasqualini R. Targeting interleukin-11 receptor in leukemia and lymphoma: A functional ligand-directed study and hematopathology analysis of patient-derived specimens. Clin Cancer Res 21(13):3041-51, 2015. e-Pub 2015. PMID: 25779950.
      80. Zurita AJ, Khajavi M, Wu HK, Tye L, Huang X, Kulke MH, Lenz HJ, Meropol NJ, Carley W, DePrimo SE, Lin E, Wang X, Harmon CS, Heymach JV. Circulating cytokines and monocyte subpopulations as biomarkers of outcome and biological activity in sunitinib-treated patients with advance neuroendocrine tumors. Br J Cancer 112(205 Suppl):1199, 2015. e-Pub 2015. PMID: 25756398.
      81. Christianson DR, Dobroff AS, Proneth B, Zurita AJ, Salameh A, Dondossola E, Makino J, Bologa CG, Smith TL, Yao VJ, Calderone TL, O'Connell DJ, Oprea TI, Kataoka K, Cahill DJ, Gershenwald JE, Sidman RL, Arap W, Pasqualini R. Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis. Proc Natl Acad Sci U S A 112(8):2521-6, 2015. e-Pub 2015. PMID: 25659743.
      82. Kearney AY, Fan YH, Giri U, Saigal B, Gandhi V, Heymach JV, Zurita AJ. 8-chloroadenosine sensitivity in renal cell carcinoma is associated with AMPK activation and mTOR pathway inhibition. PLoS One 10(8):e0135962, 2015. e-Pub 2015. PMID: 26313261.
      83. Wan X, Corn PG, Yang J, Palanisamy N, Starbuck MW, Efstathiou E, Tapia EM, Zurita AJ, Aparicio A, Ravoori MK, Vazquez ES, Robinson DR, Wu YM, Cao X, Iyer MK, McKeehan W, Kundra V, Wang F, Troncoso P, Chinnaiyan AM, Logothetis CJ, Navone NM. Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases. (Research highlights on this article published in Nature Reviews Urology on September 23, 2014 and Cancer Discovery on September 25, 2014). Sci Transl Med 6(252):252ra122, 2014. e-Pub 2014. PMID: 25186177.
      84. Mehran R, Nilsson M, Khajavi M, Du Z, Cascone T, Wu HK, Cortes A, Xu L, Zurita A, Schier R, Riedel B, El-Zein R, Heymach JV. Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy. Cancer Res 74(10):2731-41, 2014. e-Pub 2014. PMID: 24626092.
      85. Aparicio AM, Harzstark AL, Corn PG, Wen S, Araujo JC, Tu SM, Pagliaro LC, Kim J, Millikan RE, Ryan C, Tannir NM, Zurita AJ, Mathew P, Arap W, Troncoso P, Thall PF, Logothetis CJ. Platinum-based chemotherapy for variant castrate-resistant prostate cancer. Clin Cancer Res 19(13):3621-30, 2013. e-Pub 2013. PMID: 23649003.
      86. Piao Y, Liang J, Holmes L, Zurita AJ, Henry V, Heymach JV, de Groot JF. Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype. Neuro Oncol 14(11):1379-92, 2012. e-Pub 2012. PMID: 22965162.
      87. Tran HT, Liu Y, Zurita AJ, Lin Y, Baker-Neblett KL, Martin AM, Figlin RA, Hutson TE, Sternberg CN, Amado RG, Pandite LN, Heymach JV. Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol 13(8):827-37, 2012. e-Pub 2012. PMID: 22759480.
      88. Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, Rathmell WK. State of the science: an update on renal cell carcinoma. Mol Cancer Res 10(7):859-80, 2012. e-Pub 2012. PMID: 22638109.
      89. Hernandez-Yanez M, Heymach JV, Zurita AJ. Circulating biomarkers in advanced renal cell carcinoma: clinical applications. Curr Oncol Rep 14(3):221-9, 2012. e-Pub 2012. PMID: 22434312.
      90. Mateo J, Heymach JV, Zurita AJ. Circulating biomarkers of response to sunitinib in gastroenteropancreatic neuroendocrine tumors: current data and clinical outlook. Mol Diagn Ther 16(3):151-61, 2012. e-Pub 2012. PMID: 22515658.
      91. Zurita AJ, George DJ, Shore ND, Liu G, Wilding G, Hutson TE, Kozloff M, Mathew P, Harmon CS, Wang SL, Chen I, Maneval EC, Logothetis CJ. Sunitinib in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic, castration-resistant prostate cancer: a phase 1/2 clinical trial. Ann Oncol 23(3):688-94, 2012. e-Pub 2012. PMID: 21821830.
      92. Gallick GE, Corn PG, Zurita AJ, Lin SH. Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer. Future Med Chem 4(1):107-19, 2012. e-Pub 2012. PMID: 22168167.
      93. Zurita AJ, Jonasch E, Wang X, Khajavi M, Yan S, Du DZ, Xu L, Herynk MH, McKee KS, Tran HT, Logothetis CJ, Tannir NM, Heymach JV. A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol 23(1):46-52, 2012. e-Pub 2012. PMID: 21464158.
      94. Bhatt RS, Zurita AJ, O'Neill A, Norden-Zfoni A, Zhang L, Wu HK, Wen PY, George D, Sukhatme VP, Atkins MB, Heymach JV. Increased mobilization of circulating endothelial progenitors in von hippel lindau disease and renal cell carcinoma. Br J Cancer 105(1):112-7, 2011. e-Pub 2011. PMID: 21673679.
      95. Karjalainen K, Jaalouk DE, Bueso-Ramos CE, Zurita AJ, Kuniyasu A, Eckhardt BL, Marini FC, Lichtiger B, O'Brien S, Kantarjian HM, Cortes JE, Koivunen E, Arap W, Pasqualini R. Targeting neuropilin-1 in human leukemia and lymphoma. Blood 117(3):920-7, 2011. e-Pub 2011. PMID: 21063027.
      96. Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, Zurita AJ, King L. Innovations and challenges in renal cancer: summary statement from the third cambridge conference. Cancer 115(10 Suppl):2247-51, 2009. e-Pub 2009. PMID: 19402064.
      97. Mancuso P, Antoniotti P, Quarna J, Calleri A, Rabascio C, Tacchetti C, Braidotti P, Wu HK, Zurita AJ, Saronni L, Cheng JB, Shalinsky DR, Heymach JV, Bertolini F. Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses. Clin Cancer Res 15(1):267-73, 2009. e-Pub 2009. PMID: 19118054.
      98. Li ZG, Mathew P, Yang J, Starbuck MW, Zurita AJ, Liu J, Sikes C, Multani AS, Efstathiou E, Lopez A, Wang J, Fanning TV, Prieto VG, Kundra V, Vazquez ES, Troncoso P, Raymond AK, Logothetis CJ, Lin SH, Maity S, Navone NM. Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest 118(8):2697-710, 2008. e-Pub 2008. PMID: 18618013.
      99. Chu K, Cheng CJ, Ye X, Lee YC, Zurita AJ, Chen DT, Yu-Lee LY, Zhang S, Yeh ET, Hu MC, Logothetis CJ, Lin SH. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res 6(8):1259-67, 2008. e-Pub 2008. PMID: 18708358.
      100. Cardó-Vila M, Zurita AJ, Giordano RJ, Sun J, Rangel R, Guzman-Rojas L, Anobom CD, Valente AP, Almeida FC, Lahdenranta J, Kolonin MG, Arap W, Pasqualini R. A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11. PLoS One 3(10):e3452. doi:10.1371/journal.pone.0003452, 2008. e-Pub 2008. PMID: 18941632.
      101. Kolonin MG, Bover L, Sun J, Zurita AJ, Do KA, Lahdenranta J, Cardó-Vila M, Giordano RJ, Jaalouk DE, Ozawa MG, Moya CA, Souza GR, Staquicini FI, Kunyiasu A, Scudiero DA, Holbeck SL, Sausville EA, Arap W, Pasqualini R. Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries. Cancer Res 66(1):34-40, 2006. e-Pub 2006. PMID: 16397212.
      102. Chen L, Zurita AJ, Ardelt PU, Giordano RJ, Arap W, Pasqualini R. Design and validation of a bifunctional ligand display system for receptor targeting. Chem Biol 11(8):1081-91, 2004. e-Pub 2004. PMID: 15324809.
      103. Zurita AJ, Troncoso P, Cardó-Vila M, Logothetis CJ, Pasqualini R, Arap W. Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer. Cancer Res 64(2):435-9, 2004. e-Pub 2004. PMID: 14744752.
      104. Diestra JE, Condom E, Del Muro XG, Scheffer GL, Pérez J, Zurita AJ, Muñoz-Seguí J, Vigués F, Scheper RJ, Capellá G, Germà-Lluch JR, Izquierdo MA. Expression of multidrug resistance proteins P-glycoprotein, multidrug resistance protein 1, breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy: biological and clinical implications. J Urol 170(4 Pt 1):1383-87, 2003. e-Pub 2003. PMID: 14501774.
      105. Zurita AJ, Diestra JE, Condom E, García del Muro X, Scheffer GL, Scheper RJ, Pérez J, Germà-Lluch JR, Izquierdo MA. Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours. Br J Cancer 88(6):879-86, 2003. e-Pub 2003. PMID: 12644825.
      106. Capdevila O, Zurita A, Domingo E, Corbella X, Alcaide F, Monfort JL, Fernández-Viladrich P. Multiple cranial osteolytic lesions due to mycobacterium kansasii in a patient with AIDS. Scand J Infect Dis 30(3):305-6, 1998. e-Pub 1998. PMID: 9790143.

      Invited Articles

      1. Mateo J, Heymach JV, Zurita AJ. Circulating biomarkers of response to sunitinib in gastroenteropancreatic neuroendocrine tumors: current data and clinical outlook. Mol Diagn Ther 16(3):151-61, 2012. e-Pub 2012. PMID: 22515658.
      2. Hernandez-Yanez M, Heymach JV, Zurita AJ. Circulating biomarkers in advanced renal cell carcinoma: clinical applications. Curr Oncol Rep 14(3):221-9, 2012. e-Pub 2012. PMID: 22434312.
      3. Zurita AJ, Arap W, Pasqualini R. Mapping tumor vascular diversity by screening phage display libraries. Journal Controlled Release 91(1-2):183-86, 2003. e-Pub 2003. PMID: 12932650.

      Review Articles

      1. Bitar R, Zurita P, Martiniova L, Zurita AJ, Ravizzini GC. Positron Emission Tomography Radiotracers for Identification of Site of Recurrence in Prostate Cancer After Primary Treatment Failure. Cancers (Basel) 17(10), 2025. e-Pub 2025. PMID: 40427220.
      2. Venkatesh, N, Tidwell, R, Yu, Y, Aparicio, A, Zurita-Saavedra, A, Subudhi, SK, Siddiqui, BA, Gregg, JR, Corn, P, Msaouel, P, Koutroumpakis, E, McQuade, JL, Frigo, DE, Pilie, PG, Logothetis, CJ, Huff, C, Hahn, AW. Association of inherited steroidogenic genotype with body composition changes after androgen signaling inhibition (ASI) in men with biochemical recurrent (BCR), hormone-sensitive prostate cancer (HSPC). Journal of Clinical Oncology 42:108, 2024. e-Pub 2024.
      3. Zurita-Saavedra, A, Danziger, N, Scott, T, Gjoerup, OV, Zhong, L, Tukachinsky, H, Ross, JS, Graf, RP. Prognostic value of circulating tumor DNA fraction (TF) for patients with metastatic renal cell carcinoma (mRCC). Journal of Clinical Oncology 42:455, 2024. e-Pub 2024.
      4. Nordquist, LT, Lengyelova, E, Almaguel, F, Mancini, BR, Song, H, Armstrong, AJ, Zurita-Saavedra, A, Anderson, M, Parker, M, Miller, RM, Iagaru, A. COMBAT. Journal of Clinical Oncology 42:TPS247-TPS247, 2024. e-Pub 2024.
      5. Alhalabi O, Groisberg R, Zinner R, Hahn AW, Naing A, Zhang S, Tsimberidou AM, Rodon J, Fu S, Yap TA, Hong DS, Sun M, Jiang Y, Pant S, Shah AY, Zurita A, Tannir NM, Vikram R, Roszik J, Meric-Bernstam F, Subbiah V. Phase I study of sapanisertib with carboplatin and paclitaxel in mTOR pathway altered solid malignancies. NPJ Precis Oncol 7(1):37, 2023. e-Pub 2023. PMID: 37072571.
      6. Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee DH, Jimenez C, Suarez-Almazor M, Sharma P. Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience. Oncogene 34(43):5411-7, 2015. e-Pub 2015. PMID: 25659583.
      7. Zurita AJ, Jonasch E, Wu HK, Tran HT, Heymach JV. Circulating biomarkers for vascular endothelial growth factor inhibitors in renal cell carcinoma. Cancer 115(10 Suppl):2346-54, 2009. e-Pub 2009. PMID: 19402074.
      8. Ozawa MG, Zurita AJ, Dias-Neto E, Nunes DN, Sidman RL, Gelovani JG, Arap W, Pasqualini R. Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems. Trends Cardiovasc Med 18(4):126-32, 2008. e-Pub 2008. PMID: 18555185.
      9. Salar A, Carratalà J, Zurita A, González-Barca E, Grañena A. Bacteremia caused by CDC group IV c-2 in a patient with acute leukemia. Haematologica 83(7):670-72, 1998. e-Pub 1998. PMID: 9718879.

      Other Articles

      1. Chahoud J, Msaouel P, Campbell MT, Bathala T, Xiao L, Gao J, Zurita AJ, Shah AY, Jonasch E, Sharma P, Tannir NM Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis. Oncologist 25(3):252-258, 2020. PMID: 32162795.
      2. Zurita-Saavedra AJ, Rebecca S. Tidwell, Brian F. Chapin, Deborah R Harris, Miao Zhang, Louis L. Pisters, Ana Aparicio, John C. Araujo, Sara Arce-Gallego, Keyi Zhu, Maria L. Lozano, Lance Pagliaro, Joaquin Mateo, Christopher Logothetis, Patricia Troncoso, John W. Davis Randomized phase II trial of presurgical androgen deprivation therapy with or without axitinib in prostate cancer presenting with lymph node metastasis. Eur Urol Oncol.

      Editorials

      1. Zurita AJ. A second opportunity to come for anti-angiogenics in prostate cancer?. Transl Cancer Res 3(6):567-570, 2014.

      Abstracts

      1. Johns, AC, Lin, R, Johnson, L, Zhao, J, Wang, W, Jonasch, E, Campbell, M, Shah, AY, Zurita-Saavedra, A, Hahn, AW, Tannir, NM, Desai, M, Lin, JK, Marin, D, Basar, R, Daher, M, Shpall, E, Rezvani, K, Msaouel, P. TANKeR-70 44:TPS571-TPS571, 2026. e-Pub 2026.
      2. Zurita AJ, Danziger N, Scott TA, Gjoerup O, Zhong L, Tukachinsky H, Ross JS, Graf RP. Prognostic Value of Circulating Tumor DNA Fraction (TF) for Patients with Metastatic Renal Cell Carcinoma (mRCC). 2024 ASCO Genitourinary Cancer Symposium, 2024. e-Pub 2024.
      3. Nordquist LT, Lengyelova E, Almaguel F, Mancini BR, Song H, Armstrong A, Zurita AJ, Anderson M, Parker M, Miller RM, Iagaru A. (TPS247)COMBAT: A study of 64Cu-SAR-BBN and 67Cu-SAR-BBN for identification and treatment of GRPr-expressing metastatic castrate-resistant prostate cancer. 2024 ASCO Genitourinary Cancer Symposium, 2024. e-Pub 2024.
      4. Yibirin M, Mustafayev K, Hosry J, Pundhir P, Klingen J, Yepez Guevara E, Granwehr BP, Kaseb A, Naing A, Patel S, Shah AY, Skoulidis F, Tawbi HA, Wang L, Miller E, Zhang HC, Zurita-Saavedra A, Torres HA. Immune Checkpoint Inhibitors Suppress Hepatitis C Virus Replication in Infected Patients with Solid Tumors. The Liver Meeting 2022, 2022. e-Pub 2022.
      5. Viscuse P, Tidwell R, Liu J, Guo S, Vundavilli H, Zhang M, Subudhi S, Zurita A, Corn P, Tu S, Araujo J, Wang J, Efstathiou E, Wang J, Pilié P, Troncoso P, Zhang J, Wang W, Logothetis C, Aparicio A. DynAMo: A dynamic allocation modular sequential trial of approved and promising therapies in men with metastatic CRPC. 2022 ASCO Annual Meeting, 2022. e-Pub 2022.
      6. Alhalabi O, Groisberg R, Zinner R, Hahn AW, Naing A, Zhang S, Tsimberidou AM, Rodon J, Fu S, Yap TA, Hong DS, Ming S, Jiang Y, Pant S, Shah AY, Zurita A, Tannir N, Vikram R, Roszik J, Meric-Bernstam F, Subbiah V. Phase I study of mTORC1/2 inhibitor sapanisertib in combination with carboplatin plus paclitaxel in advanced solid malignancies and mTOR pathway alterations. AACR Annual Meeting 2022, 2022. e-Pub 2022.
      7. Zurita A, Graf R, Villacampa G, Raskina K, Sokol E, Jin D, Huang R, Salas I, Carles J, Ross J, Schrock A, Oxnard G, Mateo J. Genomic evolution from hormonal therapies and suitability of prostate cancer diagnostic specimens for metastatic prostate cancer (mPC) genomic stratification. 2022 ASCO Genitourinary Cancer Symposium, 2022. e-Pub 2022.
      8. Hahn A, Wang X, Efstathiou E, Hwang H, Zurita A, Spetsieris N, Boukovala M, Wang J, Araujo J, Pilié P, Siddiqui B, Subudhi S, Corn P, Aparicio A, Tu S, Logothetis C. Third analysis of a randomized trial of finite abiraterone acetate (AA) plus LHRH agonist (LHRHa) versus LHRHa in biochemically recurrent, non-metastatic hormone-naïve prostate cancer (M0HNPC), 2022. e-Pub 2022.
      9. Graf R, Fisher V, Gjoerup O, Schrock AB, Madison R, Morley S, Zhong L, Oxnard GR, Venstrom JM, Zurita AJ. Using real-world outcomes to evaluate the predictive power of tissue-assessed genomic biomarkers for taxane versus novel hormonal therapy (NHT) outcomes in metastatic castration-resistant prostate cancer (mCRPC). 2021 ASCO Annual Meeting, 2021. e-Pub 2021.
      10. Hahn AW, Tidwell R, Surasi DS, Pilie PG, Frigo D, Subudhi SK, Efstathiou E, Zurita AJ, Tu SM, Chapin BF, Fogelman DR, Starbuck MW, Corn PG, Aparicio A, McQuade JL, Logothetis C. Adiposity and response to androgen signaling inhibition (ASI) in men with metastatic castration-resistant prostate cancer (mCRPC). 2021 Genitourinary Cancers Symposium, 2021. e-Pub 2021.
      11. Viscuse PV, Zhang M, Liu J, Tidwell R, Subudhi SK, Zurita AJ, Corn PG, Tu SM, Araujo JC, Wang J, Efstathiou E, Wang J, Pilie PG, Troncoso P, Zhang J, Logothetis C, Aparicio A. Outcomes in men with metastatic castrate-resistant prostate cancer treated with early platinum-based chemotherapy following an unsatisfactory response to androgen receptor (AR) inhibition as part of the phase II dynamic allocation modular sequential (DynAMo) trial. 2021 Genitourinary Cancers Symposium, 2021. e-Pub 2021.
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      13. Karam JA Msaouel P, Matin SF, Campbell MT, Zurita AJ, Shah AY Wistuba II, Haymaker CL, Marmonti E, Douse DY, Parra ER, Solis LM, Laberiano C, Lozano M, Abraham A, Hallin M, Olson P, Der-Torossain H, Tannir NM, Wood CG. A phase II study of sitravatinib (Sitra) in combination with nivolumab (Nivo) in patients (Pts) undergoing nephrectomy for locally-advanced clear cell renal cell carcinoma (accRCC). 2021 Genitourinary Cancers Symposium, 2021. e-Pub 2021.
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      15. Viscuse P, Zhang M, Liu J, Tidwell R, Subudhi S, Zurita A, Corn P, Tu S, Araujo J, Wang J, Efstathiou E, Wang J, Pilie P, Troncoso P, Zhang J, Logothetis C, Aparicio A. Linking the Aggressive Variant Prostate Cancer (AVPC) molecular signature (-ms) to androgen indifference in a prospective clinical trial. 2020 GU ASCO, 2020. e-Pub 2020.
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      17. Ramesh N, Sei E, Tsai P, Logothetis C, Corn P, Aparicio A, Zurita A, Navin N. Plasma genome sequencing identifies prostate cancer patients that are sensitive to platinum-based therapy. 2019 AACR, 2019. e-Pub 2019.
      18. Siddiqui B, Durand J, Gao J, Wang J, Aparicio A, Campbell M, Siefker-Radtke A, Tannir N, Corn P, Msaouel P, Shah A, Zurita A, Tu S, Suarez-Almazor M, Sudhakar T, Logothetis C, Sharma P, Subudhi S. Clinical and immunological analyses of immune checkpoint inhibitor-associated neuromuscular (NM) toxicities. 2019 ASCO, 2019. e-Pub 2019.
      19. Subudhi S, Aparicio A, Zurita A, Doger B, Kelly W, Peer A, Rathkopf D, Karsh L, Tryon J, Kothari N, Zhao X, Zhu E, Ricci D, Tran N, Bono J. A phase Ib/II study of niraparib combination therapies for the treatment of metastatic castration-resistant prostate cancer (NCT03431350). 2019 ASCO(abstr TPS5087), 2019. e-Pub 2019.
      20. Aparicio A, Zhang M, Ramesh N, Wang X, Corn P, Zurita A, Davis J, Pettaway C, Adibi M, Mcguire S, Tu S, Wang J, Subudhi S, Elsheshtawi M, Efstathiou E, Logothetis C, Navin N, Troncoso P, Chapin B. Aggressive variant prostate cancer (AVPC) molecular signature in castration-sensitive, de novo metastatic prostate cancer (M1PCa). 2019 ASCO(abstr 5052), 2019. e-Pub 2019.
      21. Gao J, Karam J, Tannir N, Campbell M, Tidwell R, Ahrar K, Rao P, Ng C, Jonasch E, Matin S, Zurita A, Shah A, Shen Y, Blando J, Vence L, Basu S, Zhao H, Allison J, Wood C, Sharma P. A pilot randomized study evaluating nivolumab (nivo) or nivo + bevacizumab (bev) or nivo + ipilimumab (ipi) in patients with metastatic renal cell carcinoma (MRCC) eligible for cytoreductive nephrectomy, metastasectomy or post-treatment biopsy (Bx). 2019 ASCO(abstr 4501), 2019. e-Pub 2019.
      22. Chapin B, Wang X, Zhang M, Corn P, Zurita A, Elsheshtawi M, Davis J, Pettaway C, Adibi M, Gleave M, Cooperberg M, Smaldone M, Mcguire S, Tu S, Wang J, Subudhi S, Efstathiou E, Logothetis C, Troncoso P, Aparicio A. Complex biologic heterogeneity of de novo hormone naïve metastatic prostate cancer (HNPCa): Comparison of early progressors and prolonged responders to initial systemic treatment. 2019 ASCO(abstr 5055), 2019. e-Pub 2019.
      23. Zurita A, Tidwell R, Troncoso P, Chapin B, Harris D, Pisters, Araujo J, CPettaway, Aparicio A, Tu S, Papadopoulos J, Wang J, Logothetis C, Pagliaro L, Davis J. Randomized phase II trial of presurgical androgen deprivation therapy (ADT) with or without axitinib in prostate cancer (PCa) presenting with lymph node (LN) metastasis. 2019 ASCO(abstr 5078), 2019. e-Pub 2019.
      24. Laccetti A, Economides M, Venkatesan A, Gao J, Jonasch E, Corn P, Zurita A, Tannir N, Msaouel P, Shah A, Campbell M. Combination anti-angiogenic tyrosine kinase inhibition and anti-PD1 immunotherapy in metastatic renal cell carcinoma: A retrospective analysis of safety, tolerance, and clinical outcomes. 2019 GU ASCO, 2019. e-Pub 2019.
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      29. Vaishampayan U, McDermott D, Matrana M, Rha S, Zurita A, Ho T, Keam B, Lee J, Joseph R, Ali S, Stadler W, Haas N, Sundararajan S, Park S, Mowat R, Picus J, Dudek A, Zakharia Y, Gan L, Atkins M. A phase 1/2 study evaluating the efficacy and safety of the oral CXCR4 inhibitor X4P-001 in combination with axitinib in patients with advanced renal cell carcinoma. 2018 ASCO, 2018. e-Pub 2018.
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      83. Zurita AJ, Ward JF, Araujo JC, Pettaway CA, Pisters LL, Dieringer P, Troncoso P, Logothetis CJ. Presurgical sunitinib malate and androgen ablation in patients with localized prostate cancer at high risk for recurrence. J Clin Oncol 26, 2008. e-Pub 2008.
      84. Tannir NM, Zurita AJ, Heymach JV, Tran HT, Pagilaro LC, Corn P, Aparicio AM, Ashe R, Wright JJ, Jonasch E. A randomized phase II trial of sorafenib versus sorafenib plus low-dose interferon-alfa: Clinical results and biomarker analysis. J Clin Oncol 26, 2008. e-Pub 2008.
      85. Zurita A, Jonasch E, Du D, Yan S, Wang X, Xu L, Herynk M, McKee K, Tran H, Tannir N, Heymach J. Cytokine and angiogenic factor (CAF) profiling for prediction of outcome to first line sorafenib (SR) versus SR plus low-dose interferon-{alpha} (IFN{alpha}) in patients with advanced renal cell carcinoma (mRCC). 2008 Annual AACR Meeting (#LB-218), 2008. e-Pub 2008.
      86. Zurita AJ, Shore ND, Kozloff MF, Ryan CW, Beer TM, Maneval EC, Chen I, Logothetis CJ. Phase I study of sunitinib in combination with docetaxel and prednisone in metastatic castrate-resistant prostate cancer (CRPC). Department of Defense Prostate Cancer Research Program and Technical Planning Committee for the Innovative Minds in Prostate Cancer Today (IMPaCT); Presentation, 2007. e-Pub 2007.
      87. Zurita AJ, Shore ND, Kozloff MF, Ryan CW, Beer TM, Maneval EC, Chen I, Logothetis CJ. A phase I/II study of sunitinib in combination with docetaxel (dcx) and prednisone (pdn) in patients with metastatic castrate-resistant prostate cancer (mCRPC). ECCO 14, 2007. e-Pub 2007.
      88. Zurita AJ, Shore ND, Kozloff MF, Ryan CW, Beer TW, Chow-Maneval E, Chen I, Logothetis CJ. Distinct patterns of PSA modulation by single-agent sunitinib before combination with docetaxel and prednisone in patients with metastatic castrate-resistant prostate cancer (CRPCa). J Clin Oncol 25(18S), 2007. e-Pub 2007.
      89. Zurita AJ, Shore ND, Kozloff MF, Ryan CW, Beer TW, Chow-Maneval E, Chen I, Logothetis CJ. Phase I study of sunitinib in combination with docetaxel and prednisone in patients (pts) with metastatic hormone refractory prostate cancer (mHRPC). Prostate Cancer Symposium ASCO, 2007. e-Pub 2007.
      90. Zurita A, Wu HK, Kulke M, Tye L, Bello C, PePrimo S, McKee K, Heymach J. Sunitinib affects specific subpopulations of peripheral blood monocytic cells in patients with unresectable neuroendocrine tumor (NET): an 8-color flow cytometry analysis. 2007 AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics (#C162), 2007. e-Pub 2007.
      91. Jaalouk DE, Kuniyasu A, Zurita A, Beran M, Arap W, Pasqualini R. Targeting of cell surface receptors in leukemia with ligand-directed pro-apoptotic peptides. 14th Annual SPORE Investigators’ Workshop, 2005. e-Pub 2005.
      92. Zurita AJ, Hajitou A, Cardó-Vila M, Troncoso P, Logothetis CJ, Pasqualini R, Arap W. Preclinical development of an interleukin-11 receptor-targeted pro-apoptotic peptide against advanced prostate cancer. 40th Annual Meeting of the American Society of Clinical Oncology; Proc ASCO, 2004. e-Pub 2004.
      93. Bover LC, Holbeck S, Scudiero DA, Zurita AJ, Sausville E, Pasqualini R, Arap W. Targeting the NCI 60-cell panel by biopanning and rapid analysis of selective interactive ligands. AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics; Poster, 2003. e-Pub 2003.
      94. Zurita AJ, Troncoso P, Logothetis CJ, Pasqualini R, Arap W. A ligand peptide with potential for targeting prostate cancer metastatic to the bone marrow. 94th Annual Meeting of the American Association for Cancer Research; Proc AACR 44, 2003. e-Pub 2003.
      95. Gil M, Majem M, Mora J, Perez J, Ponce J, Izquierdo MA, Zurita A, Germà JR. Radioimmunoscintigraphy with indium-111-labeled monoclonal antibody b72.3 in epithelial ovarian cancer. European Cancer Conference (ECCO 12); Eur J Cancer Sppls 1(5):S310, 2003. e-Pub 2003.

      Book Chapters

      1. H. C. Zhang, S. Ngo, D. Chatterjee, E. Miller, Zurita-Saavedra AJ, L. Wang. Hepatobiliary Toxicity Secondary to Immune Checkpoint Inhibitor Therapy: Early Tocilizumab Treatment to Decouple Steroid Dependency. In: Challenging Cases in Immunotherapy Related Organ Toxicities. 1. Springer Cham, 243-255, 2025.
      2. Zhang, HC, Miller, E, Wang, L, Ngo, S, Chatterjee, D, Zurita-Saavedra, A. Hepatobiliary Toxicity Secondary to Immune Checkpoint Inhibitor Therapy, 243-255, 2025.
      3. Ro J, Divatia M, Guo CC, Ozcan A. Renal Cell Carcinoma: Oncologist Point of View. In: Kidney Cancer: Recent Advances in Surgical and Molecular Pathology. 1. Springer International Publishing, 21-29, 2019.
      4. Heymach JV, Zurita-Saavedra A, Kopetz S, Cascone T, Nilsson M. 17 Tumor angiogenesis. In: In Holland-Frei Cancer Medicine. 9th. Wiley-Blackwell, 2017.
      5. Zurita AJ, Ward JF, Kim J. Targeted Therapy in Prostate Cancer. In: Targeted Therapy in Cancer. The Humana Press, USA, 289-304, 2008.
      6. Zurita AJ, Arap W, Pasqualini R. Molecular Characterization of the Endothelium: A Phage Display Perspective The Endothelium: a phage display perspective the endothelium. In: A Comprehensive Reference: The Endothelial Cell as Imput-Ouptut Device/Output/Proteome. Marcel Dekker, Inc, 898-908, 2007.
      7. Zurita AJ, Wu HK, Heymach JV. Blood-Based Biomarkers for VEGF inhibitors. In: Antiangiogenic Cancer Therapy. Taylor and Francis Group, LLC Authors, 517-31, 2007.

      Letters to the Editor

      1. Zurita Saavedra AJ, Navarro Garcia M, Español I, Fernández Ortega A. UFT-induced haemolytic anaemia. Cancer Chemother Pharmacol 47: 280-81, 2001.

      Patents

      1. Arap W, Kolonin MG, Mintz PJ, Pasqualini R, Zurita AJ. Compositions and Methods of Use of Targeting Peptides for Diagnosis and Therapy of Human Cancer. Patent Number: 10530168, PCT/US02/34987, Patent: 7671010/8507445.
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      CV information above last modified September 09, 2026

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