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Ann H Klopp, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Ann Klopp is an Assistant Professor of Radiation Oncology at The University of Texas MD Anderson Cancer Center.  She is a physician-scientist specializing in the treatment of gynecologic cancers with 50% of her time devoted to laboratory research. Her laboratory research is focused on understanding effects of adipose and bone-marrow derived stem cells in gynecologic cancers.  Clinically, she is interested in the management of advanced endometrial cancers and the use of advanced radiation techniques to minimize toxicity.  In addition, Dr. Klopp has a strong interest in education and mentoring trainees in both clinical and translational research.

Education & Training

Degree-Granting Education

2003 Medical College of Wisconsin, Milwaukee, WI, MD, Medicine
2002 Medical College of Wisconsin, Milwaukee, WI, PHD, Microbiology and Molecular Biology
1996 University of Michigan, Ann Arbor, MI, BS, Microbiology

Postgraduate Training

7/2006-6/2007 Research Fellowship, Tumor Microenvironment, The University of Texas MD Anderson Cancer Center, Department of Stem Cell Transplant and Cellular Therapy, Houston, TX
9/2004-6/2008 Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Crane
7/2003-8/2004 Clinical Internship, Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, Dr. Shapiro


Institutional Committee Activities

Committee Member, Psychosocial, Behavioral, and Health Services Research Committee, 9/2010-8/2012

Honors and Awards

2007 Fletcher Award for Best Resident Manuscript, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology
2007 National AAWR Eleanor Montague Distinguished Resident Award in Radiation Oncology, AAWR
2007 Roentgen Award from RSNA for Resident Research, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology
2006 Young Oncologist Essay Award, American Radium Society
2003 Maurice Greenberg Award for Graduate Pursuing Radiation Oncology, Medical College of Wisconsin
2001 Department of Microbiology Trainee Travel Award, Medical College of Wisconsin
2000 Department of Microbiology Trainee Travel Award, Medical College of Wisconsin
1996 Angel Award for Academic Achievement, University of Michigan

Professional Memberships

American Association for Cancer Research, Philadelphia, PA
Member, 2008-present
American Association for Women Radiologists, Houston, TX
Member, 2006-present
American Brachytherapy Society, Reston, VA
Member, 2009-present
American Society for Radiation Oncology, Fairfax, VA
Chair, Endometrial Cancer Guideline Committee, 2010-2014
Member, 2006-present
American Society of Clinical Oncology, Alexandria, VA
Member, 2010-present
Gynecologic Oncology Group (GOG), Philadelphia, PA
Endometrial Committee Member, 9/2011-present
NCI Gynecologic Cancer Steering Committee (GCSC), Bethesda, MD
Junior Investigator, 6/2012-5/2014
Radiological Society of North America, Oakbrook, IL
Member, 2005-present
Society of Gynecologic Oncology, Chicago, IL
Member, 2013-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially HPV-related malignancies. Head Neck 36(6):819-25, 6/2014. e-Pub 9/2/2013. PMID: 23720126.
2. Tsai CJ, Sulman EP, Eifel PJ, Jhingran A, Allen PK, Deavers MT, Klopp AH. Galectin-7 Levels Predict Radiation Response in Squamous Cell Carcinoma of the Cervix. Gynecol Oncol 131(3):645-9, 12/2013. e-Pub 4/30/2013. PMID: 23643871.
3. Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC. Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. Cancer Res 73(17):5347-59, 9/1/2013. e-Pub 7/9/2013. PMCID: PMC3767181.
4. Brown AP, Jhingran A, Klopp AH, Schmeler KM, Ramirez PT, Eifel PJ. Involved-field radiation therapy for locoregionally recurrent ovarian cancer. Gynecol Oncol 130(2):300-5, 8/2013. e-Pub 5/4/2013. PMID: 23648467.
5. Mikell JK, Klopp AH, Price M, Mourtada F. Commissioning of a grid-based Boltzmann solver for cervical cancer brachytherapy treatment planning with shielded colpostats. Brachytherapy. e-Pub 7/2013. PMID: 23891341.
6. Klopp AH, Moughan J, Portelance L, Miller BE, Salehpour MR, Hildebrandt E, Nuanjing J, D'Souza D, Souhami L, Small W, Gaur R, Jhingran A. Hematologic toxicity in RTOG 0418: a phase 2 study of postoperative IMRT for gynecologic cancer. Int J Radiat Oncol Biol Phys 86(1):83-90, 5/1/2013. PMID: 23582248.
7. Klopp AH, Mourtada F, Yu ZH, Beadle BM, Munsell MF, Jhingran A, Eifel PJ. Pilot study of a computed tomography-compatible shielded intracavitary brachytherapy applicator for treatment of cervical cancer. Pract Radiat Oncol 3(2):115-123, Apr-Jun, 4/2013. e-Pub 5/11/2012. PMID: 24674314.
8. Takiar V, Fontanilla HP, Eifel PJ, Jhingran A, Kelly P, Iyer RB, Levenback CF, Zhang Y, Dong L, Klopp A. Anatomic Distribution of Fluorodeoxyglucose-Avid Para-aortic Lymph Nodes in Patients With Cervical Cancer. Int J Radiat Oncol Biol Phys 85(4):1045-50, 3/15/2013. e-Pub 1/17/2013. PMID: 23332221.
9. Fontanilla HP, Klopp AH, Lindberg ME, Jhingran A, Kelly P, Takiar V, Iyer RB, Levenback CF, Zhang Y, Dong L, Eifel PJ. Anatomic distribution of [18F] fluorodeoxyglucose-avid lymph nodes in patients with cervical cancer. Pract Radiat Oncol 3(1):45-53, Jan-Mar, 1/2013. e-Pub 3/30/2012. PMID: 24674263.
10. Shirvani SM, Klopp AH, Likhacheva A, Jhingran A, Soliman PT, Lu KH, Eifel PJ. Intensity modulated radiation therapy for definitive treatment of paraortic relapse in patients with endometrial cancer. Pract Radiat Oncol 3(1):e21-8, Jan-Mar, 1/2013. e-Pub 5/3/2012. PMID: 24674269.
11. Klopp AH, Mourtada F, Yu ZH, Beadle BM, Munsell MF, Jhingran A, Eifel PJ. Pilot study of a computed tomography-compatible shielded intracavitary brachytherapy applicator for treatment of cervical cancer. Pract Radiat Oncol 3(2):115-123, 2013.
12. Frumovitz M, Ramirez PT, Macapinlac HA, Klopp AH, Nick AM, Ramondetta LM, Jhingran A. Anatomic location of PET-positive aortocaval nodes in patients with locally advanced cervical cancer: Implications for surgical staging. Int J Gynecol Cancer 22(7):1203-7, 9/2012. e-Pub 7/2012. PMID: 22810967.
13. Mikell JK, Klopp AH, Gonzalez GM, Kisling KD, Price MJ, Berner PA, Eifel PJ, Mourtada F. Impact of heterogeneity-based dose calculation using a deterministic grid-based boltzmann equation solver for intracavitary brachytherapy. Int J Radiat Oncol Biol Phys 83(3):e417-22, 7/1/2012. e-Pub 3/19/2012. PMCID: PMC3955059.
14. Shirvani S, Klopp AH, Eifel PJ, Soliman PT, Jhingran A Likhacheva A, Lu KH. Intensity-modulated radiotherapy for definitive treatment of para-aortic relapse in patients with endometrial cancer. Pract Radiat Oncol. e-Pub 5/2012.
15. Klopp AH, Zhang Y, Solley T, Amaya-Manzanares F, Marini F, Andreeff M, Debeb B, Woodward W, Schmandt R, Broaddus R, Lu K, Kolonin MG. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors. Clin Cancer Res 18(3):771-82, 2/1/2012. e-Pub 12/13/2011. PMCID: PMC3481843.
16. Kidd S, Spaeth E, Watson K, Burks J, Lu H, Klopp A, Andreeff M, Marini FC. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7(2):e30563, 2012. e-Pub 2/2012.
17. Klopp AH, Eifel PJ. Chemoradiotherapy for cervical cancer in 2010. Curr Oncol Rep 13(1):77-85, 2/2011. e-Pub 11/2010. PMID: 21042887.
18. Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F. Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29(1):11-9, 1/2011. PMCID: PMC3059412.
19. Turner LM, Howard JA, Dehghanpour P, Barrett RD, Rebueno N, Palmer M, Vedam S, Klopp A, Komaki R, Welsh JW. Exploring the feasibility of dose escalation positron emission tomography-positive disease with intensity-modulated radiation therapy and the effects on normal tissue structures for thoracic malignancies. Med Dosim. e-Pub 12/2010. PMID: 21144734.
20. Garg AK, Jhingran A, Klopp AH, Aggarwal BB, Kunnumakkara AB, Broadus RR, Eifel PJ, Buchholz TA. Expression of nuclear transcription factor Kappa B in locally advanced human cervical cancer treated with definitive chemoradiation. Int J Radiat Oncol Biol Phys 78(5):1331-6, 12/2010. e-Pub 3/2010. PMID: 20231067.
21. Clements A, Euscher E, Lacour R, Merritt W, Klopp A, Ramondetta L. The presence of human papillomavirus or p16 in six cases of retroperitoneal carcinoma. Obstet Gynecol 116(5):1042-6, 11/2010. PMID: 20966687.
22. Klopp AH, Lacerda L, Gupta A, Debeb BG, Solley T, Li L, Spaeth E, Xu W, Zhang X, Lewis MT, Reuben JM, Krishnamurthy S, Ferrari M, Gaspar R, Buchholz TA, Cristofanilli M, Marini F, Andreeff M, Woodward WA. Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS One 5(8):e12180, 2010. e-Pub 8/16/2010. PMCID: PMC2922340.
23. Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A, Battula VL, Weil M, Andreeff M, Marini FC. Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 27(10):2614-23, 10/2009. PMID: 19650040.
24. Klopp AH, Jhingran A, Ramondetta L, Lu K, Gershenson DM, Eifel PJ. Node-positive adenocarcinoma of the endometrium: Outcome and patterns of recurrence with and without external beam irradiation. Gynecol Oncol 115(1):6-11, 10/2009. e-Pub 7/25/2009. PMID: 19632709.
25. Sulman EP, Komaki R, Klopp AH, Cox JD, Chang JY. Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer. Radiat Oncol 4:5, 2009. PMCID: PMC2651897.
26. Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M, Marini F. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One 4(4):e4992, 2009. e-Pub 4/7/2009. PMCID: PMC2661372.
27. Klopp AH, Woodward WA. Therapeutic strategies to eliminate breast cancer stem cells. Current Breast Cancer Reports 1:222-228, 2009.
28. Klopp AH, Jhingran A, Ramdas L, Story MD, Broadus RR, Lu KH, Eifel PJ, Buchholz TA. Gene expression changes in cervical squamous cell carcinoma after initiation of chemoradiation and correlation with clinical outcome. Int J Radiat Oncol Biol Phys 71(1):226-36, 5/2008. PMID: 18406887.
29. Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F. Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 15(10):730-8, 5/2008. PMID: 18401438.
30. Kidd S, Spaeth E, Klopp A, Andreeff M, Hall B, Marini FC. The (in) auspicious role of mesenchymal stromal cells in cancer: be it friend or foe. Cytotherapy 10(7):657-67, 2008. PMID: 18985472.
31. Klopp AH, Chang JY, Tucker SL, Sulman EP, Balter PA, Liu HH, Bucci MK, Macapinlac HA, Komaki R, Cox JD. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys 69(5):1409-16, 12/2007. PMID: 17904303.
32. Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC. Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 67(24):11687-95, 12/2007. PMID: 18089798.
33. Klopp AH, Eapen GA, Komaki RR. Endobronchial brachytherapy: an effective option for palliation of malignant bronchial obstruction. Clin Lung Cancer 8(3):203-7, 11/2006. PMID: 17239296.
34. Klopp AH, Eifel PJ. Gene expression profiling in cervical cancer: state of the art and future directions. Cancer J 12(3):170-4, May-Jun, 5/2006. PMID: 16803672.
35. Hoge AT, Hendrickson SB, Burns WH. Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency. J Virol 74(15):7016-23, 8/2000. PMID: 10888640.
36. Paradee W, Wilke CM, Wang L, Shridhar R, Mullins CM, Hoge A, Glover TW, Smith DI. A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics 35(1):87-93, 7/1996. PMID: 8661108.
37. Wilke CM, Hall BK, Hoge A, Paradee W, Smith DI, Glover TW. FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum Mol Genet 5(2):187-195, 1996.

Invited Articles

1. Klopp AH, Eifel PJ. Biological predictors of cervical cancer response to radiation therapy. Semin Radiat Oncol 22(2):143-150, 4/2012. PMID: 22385921.

Book Chapters

1. Klopp AH, Eifel PJ. Ovary, Uterus (Fallopian Tube, Cervix), Vagina and Vulva. In: ALERT - Adverse Late Effects of Cancer Treatment. 2: Normal Tissue Specific Sites and Systems. Springer-Verlag: Berlin Heidelberg, 551-570, 2014.
2. Lu KH, Klopp AH, Soliman PT, and Schmandt RE. Increased Adiposity and Endometrial Cancer Risk. In: Adipose Tissue and Cancer. Ed(s) MG Kolonin. Springer: NY, 53-70, 2013.
3. Klopp A, Jhingran A. Field cancerization in vulvar, vaginal, and cervical epithelia. In: Field Cancerization: Basic Science and Clinical Applications. Ed(s) Dakubo GD. Nova Science Publications: New York, 415-421, 2011. ISBN: 978-1-61761-006-6.

Grant & Contract Support

Title: Where it’s at; The effect of adipose tissue location on cancer progression
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator
Duration: 1/1/2015 - 12/31/2019
Title: A Missing Link Between Obesity and Cancer: Adipose Derived Stem Cells
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 8/1/2014 - 7/31/2017
Title: Visceral obesity and ovarian cancer: what is the role of adipose stem cells?
Funding Source: MD Anderson Cancer Center
Role: Principal Investigator
Duration: 5/1/2014 - 1/31/2015

Last updated: 1/2/2015