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Ann H. Klopp, M.D, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Clinical Interests

Dr. Klopp specializes in the treatment of gynecologic malignancies with radiation therapy. Her clinical practice and research is devoted to the treatment of cancers of the uterus, cervix, vagina, vulva and ovary.   Each patient’s treatment is individually designed with the input of the multidisciplinary group specializing in the treatment of gynecologic cancer, including a gynecologic oncologist, pathologist, and radiologist. Radiation treatment is delivered utilizing the most current radiation therapy technology, such as intensity modulated radiation therapy and image guided radiation therapy, which can help minimize the amount of radiation given to the normal tissues. She also benefits from the collective 30 years expertise of her colleagues, Dr. Eifel and Jhingran, specializing in the treatment of gynecologic cancer with radiation therapy.

Dr. Klopp also does laboratory research, which focuses on a bone-marrow derived cell population, mesenchymal stem cells, which migrate into tumors.  Her previous research demonstrated that more of these cells are present in irradiated tumors. Her current research is investigating the biological effects of these cells on tumor response to radiation and exploring the potential to use these cells to deliver radiation sensitizers. The ultimate goal of this work is to improve cancer outcomes and quality of life for women treated with radiation therapy for gynecologic cancers. She has an interest in identifying molecular changes in cervical cancer which help to determine which patients will respond best to radiation therapy and could ultimately be used to help make treatment decisions.

Education & Training

Degree-Granting Education

2003 Medical College of Wisconsin, Milwaukee, WI, MD, Medicine
2002 Medical College of Wisconsin, Milwaukee, WI, PHD, Microbiology and Molecular Biology
1996 University of Michigan, Ann Arbor, MI, BS, Microbiology

Postgraduate Training

9/2004-6/2008 Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Crane
7/2003-8/2004 Clinical Internship, Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, Dr. Shapiro

Selected Publications

Peer-Reviewed Original Research Articles
1. Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M, Marini F. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One 4(4). e-Pub 4/2009. PMCID: PMC2661372.
2. Sulman EP, Komaki R, Klopp AH, Cox JD, Chang JY. Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer. Radiat Oncol 4:5, 2009. PMCID: PMC2651897.
3. Klopp AH, Jhingran A, Ramdas L, Story MD, Broadus RR, Lu KH, Eifel PJ, Buchholz TA. Gene expression changes in cervical squamous cell carcinoma after initiation of chemoradiation and correlation with clinical outcome. Int J Radiat Oncol Biol Phys 71(1):226-36, 5/2008. PMID: 18406887.
4. Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F. Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 15(10):730-8, 5/2008. PMID: 18401438.
5. Kidd S, Spaeth E, Klopp A, Andreeff M, Hall B, Marini FC. The (in) auspicious role of mesenchymal stromal cells in cancer: be it friend or foe. Cytotherapy 10(7):657-67, 2008. PMID: 18985472.
6. Klopp AH, Chang JY, Tucker SL, Sulman EP, Balter PA, Liu HH, Bucci MK, Macapinlac HA, Komaki R, Cox JD. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys 69(5):1409-16, 12/2007. PMID: 17904303.
7. Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC. Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 67(24):11687-95, 12/2007. PMID: 18089798.
8. Klopp AH, Eapen GA, Komaki RR. Endobronchial brachytherapy: an effective option for palliation of malignant bronchial obstruction. Clin Lung Cancer 8(3):203-7, 11/2006. PMID: 17239296.
9. Klopp AH, Eifel PJ. Gene expression profiling in cervical cancer: state of the art and future directions. Cancer J 12(3):170-4, May-Jun, 5/2006. PMID: 16803672.
10. Hoge AT, Hendrickson SB, Burns WH. Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency. J Virol 74(15):7016-23, 8/2000. PMID: 10888640.
11. Glover TW, Hoge AW, Miller DE, Ascara-Wilke JE, Adam AN, Dagenais SL, Wilke CM, Dierick HA, Beer DG. The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. Cancer Res 58(15):3409-14, 8/1998. PMID: 9699673.
12. Paradee W, Wilke CM, Wang L, Shridhar R, Mullins CM, Hoge A, Glover TW, Smith DI. A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics 35(1):87-93, 7/1996. PMID: 8661108.

Abstracts
1. Klopp AH, Chang JY, Liu H, Balter PA, Macapinlac H, Komaki R, Cox JD. Intra-thoracic patterns of failure for non-small cell lung cancer (NSCLC) with PET/CT-defined target delineation. Int J Radiat Oncol Biol Phys 66(3):S467, 2006.
2. Eifel PJ, Klopp AH, Ramondetta LM, Gershenson DM, Jhingran A. Node-positive adenocarcinoma of the endometrium: Outcome and patterns of recurrence. Int J Radiat Oncol Biol Phys 66(3):S166, 2006.

Last updated: 9/24/2009