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Carlos Bueso-Ramos, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Hematopathology and Section Chief of Diagnostic Bone Marrow, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1988 Emory University School of Medicine, Atlanta, GA, PHD, Experimental Pathology
1982 Universidad Autonoma, Tegucigalpa, Honduras, MD, Medicine

Postgraduate Training

7/1992-6/1994 Hematopathology Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX
7/1991-6/1992 Surgical Pathology/Hematopathology Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX
7/1987-6/1991 Pathology Residency Training Program (AP/CP), Emory University School of Medicine, Atlanta, GA

Selected Publications

Peer-Reviewed Original Research Articles

1. Hoehn D, Medeiros LJ, Kantarjian HM, Cortes JE, Wang X, Bueso-Ramos CE. Digital image analysis as a tool to assess the effects of imatinib on trabecular bone in patients with chronic myelogenous leukemia. Hum Pathol 43(12):2354-9, 12/2012. e-Pub 8/29/2012. PMID: 22939577.
2. Lee DW, Futami M, Carroll M, Feng Y, Wang Z, Fernandez M, Whichard Z, Chen Y, Kornblau S, Shpall EJ, Bueso-Ramos CE, Corey SJ. Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. Oncogene 31(37):4085-94, 9/13/2012. e-Pub 1/16/2012. PMID: 22249254.
3. Tong WG, Quintás-Cardama A, Kadia T, Borthakur G, Jabbour E, Ravandi F, Faderl S, Wierda W, Pierce S, Shan J, Bueso-Ramos C, Kantarjian H, Garcia-Manero G. Predicting survival of patients with hypocellular myelodysplastic syndrome: Development of a disease-specific prognostic score system. Cancer 118(18):4462-70, 9/15/2012. e-Pub 1/17/2012. PMID: 22252728.
4. Kanagal-Shamanna R, Bueso-Ramos CE, Barkoh B, Lu G, Wang S, Garcia-Manero G, Vadhan-Raj S, Hoehn D, Medeiros LJ, Yin CC. Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53. Cancer 118(11):2879-88, 6/1/2012. e-Pub 10/28/2011. PMID: 22038701.
5. Naqvi K, Jabbour E, Bueso-Ramos C, Pierce S, Borthakur G, Estrov Z, Ravandi F, Faderl S, Kantarjian H, Garcia-Manero G. Implications of discrepancy in morphologic diagnosis of myelodysplastic syndrome between referral and tertiary care centers. Blood 118(17):4690-3, 10/27/2011. e-Pub 8/25/2011. PMID: 21868570.
6. Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol 8(8):467-77, 8/2011. e-Pub 6/7/2011. PMCID: PMC3423224.
7. Zuo Z, Calin GA, de Paula HM, Medeiros LJ, Fernandez MH, Shimizu M, Garcia-Manero G, Bueso-Ramos CE. Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome. Blood 118(2):413-5, 7/14/2011. e-Pub 5/20/2011. PMCID: PMC3293748.
8. Kidd S, Bueso-Ramos C, Jagan S, Paganessi LA, Boggio LN, Fung HC, Gregory SA, Christopherson KW. In Vivo expansion of the megakaryocyte progenitor cell population in adult CD26 deficient mice. Exp Hematol 39(5):580-590.e1, 5/2011. e-Pub 2/1/2011. PMID: 21291952.
9. Pham LV, Fu L, Tamayo AT, Bueso-Ramos C, Drakos E, Vega F, Medeiros LJ, Ford RJ. Constitutive BR3 receptor signaling in diffuse large B-cell lymphomas stabilizes NF-{kappa}B-inducing kinase, while activating both canonical and alternative NF-{kappa}B pathways. Blood 117(1):200-10, 1/6/2011. e-Pub 10/1/2010. PMCID: PMC3037744.
10. Karjalainen K, Jaalouk DE, Bueso-Ramos CE, Zurita AJ, Kuniyasu A, Eckhardt BL, Marini FC, Lichtiger B, O'Brien S, Kantarjian HM, Cortes JE, Koivunen E, Arap W, Pasqualini R. Targeting neuropilin-1 in human leukemia and lymphoma. Blood 117(3):920-7, 1/20/2011. e-Pub 11/9/2010. PMCID: PMC3298438.
11. Santos FP, Bueso-Ramos CE, Ravandi F. Acute erythroleukemia: diagnosis and management. Expert Rev Hematol 3(6):705-18, 12/2010. PMID: 21091147.
12. Vadhan-Raj S, Trent J, Patel S, Zhou X, Johnson MM, Araujo D, Ludwig JA, O'Roark S, Gillenwater AM, Bueso-Ramos C, El-Naggar AK, Benjamin RS. Single-dose palifermin prevents severe oral mucositis during multicycle chemotherapy in patients with cancer: a randomized trial. Ann Intern Med 153(6):358-67, 9/21/2010. PMID: 20855800.
13. Konoplev SN, Fritsche HA, O'Brien S, Wierda WG, Keating MJ, Gornet TG, St Romain S, Wang X, Inamdar K, Johnson MR, Medeiros LJ, Bueso-Ramos CE. High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia. Am J Clin Pathol 134(3):472-7, 9/2010. PMID: 20716805.
14. Kasyan A, Medeiros LJ, Zuo Z, Santos FP, Ravandi-Kashani F, Miranda R, Vadhan-Raj S, Koeppen H, Bueso-Ramos CE. Acute erythroid leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease. Mod Pathol 23(8):1113-26, 8/2010. e-Pub 5/2010. PMID: 20473273.
15. Dimov ND, Medeiros LJ, Ravandi F, Bueso-Ramos CE. Acute promyelocytic leukemia at time of relapse commonly demonstrates cytogenetic evidence of clonal evolution and variability in blast immunophenotypic features. Am J Clin Pathol 133(3):484-90, 3/2010. PMID: 20154288.
16. Liang M, Han X, Vadhan-Raj S, Nguyen M, Zhang YH, Fernandez M, Drakos E, Konoplev SN, Yin CC, Miranda RN, McDonnell TJ, Medeiros LJ, Bueso-Ramos CE. HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis. Mod Pathol 23(3):381-91, 3/2010. e-Pub 1/8/2010. PMID: 20062013.
17. Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, Heguy A, Bueso-Ramos C, Kantarjian H, Levine RL, Verstovsek S. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 70(2):447-52, 1/15/2010. e-Pub 1/12/2010. PMID: 20068184.
18. Dimov ND, Medeiros LJ, Kantarjian HM, Cortes JE, Chang KS, Bueso-Ramos CE, Ravandi F. Rapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with an antipromyelocytic leukemia antibody: the M. D. Anderson Cancer Center experience of 349 patients. Cancer 116(2):369-76, 1/15/2010. PMID: 19950129.
19. Chen W, Konoplev S, Medeiros LJ, Koeppen H, Leventaki V, Vadhan-Raj S, Jones D, Kantarjian HM, Falini B, Bueso-Ramos CE. Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation. Cancer 115(23):5481-9, 12/1/2009. e-Pub 8/11/2009. PMID: 19672946.
20. Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, Neuberg D, Kornblau SM, Issa JP, Gilliland DG, Garcia-Manero G, Kantarjian HM, Estey EH, Look AT. Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia 23(9):1605-13, 9/2009. e-Pub 4/23/2009. PMID: 19387468.

Last updated: 7/30/2014