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Chun Li, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Ad Interim Chief, Section of Chemistry, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, PET Center, Zhejiang University, Hangzhou, Zhejiang, China
Faculty, Graduate School of Biological Sciences, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX
Adjunct Professor, Biomedical Engineering and Nanomedicine, The University of Texas Health Science Center at Houston, Houston, TX
Adjunct Professor, College of Pharmacy, University of Houston, Houston, TX

Research Interests

Molecular imaging, Drug delivery systems, Nanotechnology

Research activities in my laboratory are primarily focused on two areas: 1) the development of targeted imaging probes for noninvasive characterization of molecular events associated with tumor progression and regression and 2) the development of novel drug-delivery systems for selective delivery of diagnostic and therapeutic agents. Molecular imaging probes used in nuclear, optical, and magnetic resonance imaging modalities are designed to enhance the sensitivity and selectivity of early tumor detection, tumor-marker profiling, and the monitoring of early treatment responses. Targeted drug delivery, on the other hand, uses nanometric drug carriers to selectively deliver anticancer agents to the tumor to maximize their therapeutic efficacy and minimize their toxic side effects to the normal tissues. Our long-term goal is to apply the "seek and treat" strategy in the development of targeted imaging/therapeutic agents that will eventually be translated to the clinic to improve the management of cancer through early tumor detection and individualized therapy.

Office Address

The University of Texas MD Anderson Cancer Center
1881 East Road
Unit Number: 1907
Houston, TX 77054-1907
Room Number: 3SCR4.3636
Phone: (713) 792-5182
Fax: (713) 834-6073
Email: cli@mdanderson.org

Education & Training

Degree-Granting Education

1991 Rutgers-The State University of New Jersey, New Brunswick, NJ, PHD, Chemistry
1983 Peking University, Beijing, China, BS, Chemistry

Postgraduate Training

2/1991-8/1993 Research Associate, The University of Texas MD Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Professor, Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2006-5/2013
Adjunct Associate Professor, Dept. of Bioengineering, Rice University, Houston, TX, 2/2005-9/2007
Adjunct Associate Professor, Dept. of Chemical Engineering, Texas A&M University, College Station, TX, 2/2002-9/2005
Associate Professor, Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2000-9/2006
Assistant Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/1994-9/2000
Instructor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/1993-7/1994
Instructor, Analytical and Testing Center, Sichuan University, Chengdu, Sichuan, China, 1/1983-1/1986

Other Appointments/Responsibilities

Research Associate, The University of Texas MD Anderson Cancer Center, Houston, TX, 1991-1993

Consultantships

DEBIOPHARM SA, Lausanne, Switzerland, 7/2012-present
Consultant, Medivation, Inc., San Francisco, CA, 10/2009-10/2010
Consultant, Cell Therapeutics, Inc., Seattle, WA, 12/1998-12/2000

Institutional Committee Activities

Member, Grant Review Committee for Sister Institution Network Funding (SINF), 2011-present
Executive Steering Committee Member, Center for Advanced Biomedical Imaging (CABI), 2011-present
Member, Alliance for NanoHealth Scientific Advisory Board, 2006-present
Steering Committee Member, Small Animal Imaging Facility (SAIF), 2003-present
Member, Institutional Radiation Safety Committee, 2002-2012
Member, Radioactive Drug Research Committee (RDRC), 2002-2005

Honors and Awards

1998 Merit Award for Scientific Exhibit, 84th Scientific Assembly, Radiological Society of North America
1989 Summer Fellowship Award for Outstanding Achievement in Graduate Research, Rutgers University

Professional Memberships

American Association of Cancer Research
Member, 1/1992-present
American Association of Pharmaceutical Scientists
Member, 1992-2009
American Chemical Society
Member, 1/1988-present
Controlled Release Society
Member, 1/1989-present
Society of Nuclear Medicine
Member, 2005-present
World Molecular Imaging Congress
Member, 2003-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Li C. A targeted approach to cancer imaging and therapy. Nat Mater 13(2):110-5, 2014. PMID: 24452345.
2. Huang M, Xiong C, Lu W, Zhang R, Zhou M, Huang Q, Weinberg J, Li C. Dual-modality micro-positron emission tomography/computed tomography and near-infrared fluorescence imaging of EphB4 in orthotopic glioblastoma xenograft models. Mol Imaging Biol 16(1):74-84, 2014. PMCID: PMC3947091.
3. Zhang R, Huang M, Zhou M, Wen X, Huang Q, Li C. Annexin A5-functionalized nanoparticle for multimodal imaging of cell death. Mol Imaging 12(3):182-190, 5/2013. PMID: 23490444.
4. Song SL, Xiong CY, Lu W, Ku G, Huang G, Li C. Apoptosis imaging probe predicts early chemotherapy response in preclinical models: a comparative study with 18F-FDG PET. J Nucl Med 54(1):104-110, 2013. PMID: 23283564.
5. Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging. Molecules 18(6):6425-6438, 2013. PMID: 23722731.
6. Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Rel 172(1):152-158, 2013. PMCID: PMC3853126.
7. You J, Wang ZH, Du YZ, Yuan H, Zhang PZ, Zhou JL, Liu F, Li C, Hu FQ. Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres. Biomaterials 34(18):4510-4519, 2013. PMID: 23510855.
8. Tian M, Lu W, Zhang R, Xiong C, Ensor J, Nazario J, Jackson J, Shaw C, Dixon KA, Miller J, Wright K, Li C, Gupta S. Tumor uptake of hollow gold nanospheres after intravenous and transcatheter arterial injection: A PET/CT study in a rabbit VX2 liver cancer model. Mol Imaging Biol 15(5):614-24, 2013. PMID: 23608932.
9. Shen HF, You J, Zhang GD, Ziemys A, Li QP, Bai LT, Deng XY, Erm DR, Liu XW, Li C, Ferrari M. Cooperative, nanoparticle-enabled thermal therapy of breast cancer. Adv Healthcare Mat (Cover Illustration). 1(1):84-89, 2012. PMCID: PMC3842222.
10. Ku G, Zhou M, Song S, Huang Q, Hazle J, Li C. Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. ACS Nano 6(8):7489-96, 2012. PMCID: PMC3429766.
11. Zhao J, Song S, Zhong M, Li C. Dual-modal tumor imaging via long-circulating biodegradable core-crosslinked polymeric micelles. ACS Macro Lett 1(1):150-153, 2012. PMCID: PMC3367665.
12. You J, Zhang R, Xiong C, Zhong M, Melancon M, Gupta S, Nick AM, Sood AK, Li C. Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors. Cancer Res (Cover Illustration) 72(18):4777-86, 2012. PMCID: PMC3445780.
13. Gupta S, Stafford RJ, Javedi S, Ozkan E, Ensor J, Wright K, Elliot A, Jian Y, Serda R, Wallace M, Li C. Effects of near-infrared laser irradiation of biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intra-arterially in a rabbit liver tumor model. J Vas Interv Radiol 23(4):553-561, 2012. PMID: 22341633.
14. You J, Zhang R, Zhang G-D, Zhong M, Liu Y, Van Pelt CS, Liang D, Wei W, Sood AK, Li C. Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. J Controlled Rel 158(2):319-328, 2012. PMCID: PMC3463239.
15. Lu W, Xiong C, Zhang R, Shi L, Huang M, Zhang G, Song S, Huang Q, Liu GY, Li C. Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors. J Control Rel (Cover Illustration) 161(3):959-966, 2012. PMCID: PMC3412909.
16. Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong CY, Hittelman WN, Wen XX, Marks JW, Cheung LH, Boland K, Adams GP, Li C, Rosenblum MG. Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Mol Cancer Ther 11(1):143-153, 2012. PMID: 22090420.
17. Yang Z, Xiong C, Zhang R, Zhu H, Li C. Synthesis and evaluation of (68)Ga-labeled DOTA-2-deoxy-D-glucosamine as a potential radiotracer in μPET imaging. Am J Nucl Med Mol Imaging 2(4):499-507, 2012. PMCID: PMC3484416.
18. Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials 33(21):5376-5383, 2012. PMCID: PMC3356511.
19. Perin EC, Tian M, Marini III FC, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Shpall E, Gelovani JG. Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One 6(9):e22949, 2011. PMCID: PMC3164664.
20. Xiong C, Huang M, Zhang R, Song S, Lu W, Flores L, Gelovani J, Li C. In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptide. J Nucl Med 52(2):241-8, 2011. PMID: 21233177.
21. Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release 156(2):265-272, 2011. PMCID: PMC3203335.
22. Xiong C, Brewer K, Song S, Zhang R, Lu W, Wen X, Li C. Peptide-based imaging agents targeting phosphatidylserine for the detection of apoptosis. J Med Chem 54(6):1825-35, 2011. PMID: 21348464.
23. Zhang R, Xiong C, Huang M, Zhou M, Huang Q, Wen X, Liang D, Li C. Peptide-conjugated polymeric micellar nanoparticles for dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts. Biomaterials 32(25):5872-9, 2011. PMCID: PMC3110559.
24. Tian M, Wen X, Jackson EF, Ng C, Uthamanthil R, Liang D, Gelovani JG, Li C. Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study. Contrast Media Mol Imaging 6(4):289-97, 2011. PMCID: PMC3435886.
25. Song S, Xiong C, Zhou M, Lu W, Huang Q, Ku G, Zhao J, Flores LG, Ni Y, Li C. Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-Bis-DOTA-hypericin. J Nucl Med 52(5):792-9, 2011. PMID: 21498539.
26. Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multi-functional gold-based nanoshells for MR-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. PMCID: PMC3195359.
27. Melancon MP, Elliott A, Ji X, Shetty A, Yang Z, Tian M, Taylor B, Stafford RJ, Li C. Theranostics with multifunctional magnetic gold nanoshells: photothermal therapy and T2* magnetic resonance imaging. Invest Radiol 46(2):132-40, 2011. PMCID: PMC3435880.
28. Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132(43):15351-8, 2010. PMCID: PMC2966020.
29. Wen X, Lyu MA, Zhang R, Lu W, Huang Q, Liang D, Rosenblum MG, Li C. Biodistribution, pharmacokinetics, and nuclear imaging studies of (111)In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma. Mol Imaging Biol 13(4):721-9, 2010. PMID: 20686856.
30. Li Y, Lu W, Huang Q, Huang M, Li C, Chen W. Copper sulfide nanoparticles for photothermal ablation of tumor cells. Nanomedicine (Lond) 5(8):1161-71, 2010. PMID: 21039194.
31. Belousova N, Mikheeva G, Xiong C, Soghomonian S, Young D, Le Roux L, Naff K, Bidaut L, Wei W, Li C, Gelovani J, Krasnykh V. Development of a targeted gene vector platform based on simian adenovirus serotype 24. J Virol 84(19):10087-101, 2010. PMCID: PMC2937776.
32. You J, Zhang G, Li C. Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release. ACS Nano 4(2):1033-41, 2010. PMCID: PMC2835401.
33. Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behavior. Nanomedicine (London) 5(9):1357-69, 2010. PMCID: PMC3057775.
34. You J, Shao R, Wei X, Gupta S, Li C. Near-infrared light triggers release of Paclitaxel from biodegradable microspheres: photothermal effect and enhanced antitumor activity. SMALL 6(9):1022-31, 2010. PMCID: PMC3435885.
35. Lu W, Huang Q, Ku G, Wen X, Zhou M, Guzatov D, Brecht P, Su R, Oraevsky A, Wang LV, Li C. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials 31(9):2617-26, 2010. PMCID: PMC2813997.
36. Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials 31(25):6567-73, 2010. PMCID: PMC2900486.
37. Lu W, Zhang G, Zhang R, Flores LG, Huang Q, Gelovani JG, Li C. Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Res 70(8):3177-88, 2010. PMCID: PMC2856125.
38. Xiong C, Yang Z, Zhang R, Tong W, Gelovani J, Li C. 99mTc-labeled Ac-DEVD peptides as a substrate for measuring caspase activity. Adv Exp Med Biol 611:455-6, 2009. PMID: 19400264.
39. Xiong C, Lu W, Zhang R, Tian M, Tong W, Gelovani J, Li C. Cell-permeable [99mTc(CO3)]-labeled fluorogenic caspase 3 substrate for dual-modality detection of apoptosis. Chemistry 15(36):8979-84, 2009. PMID: 19637160.
40. Yang Z, Kontoyiannis DP, Wen X, Xiong C, Zhang R, Albert ND, Li C. Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with a (111)In-labeled cyclic peptide. Nucl Med Biol 36(3):259-66, 2009. PMID: 19324271.
41. Zhang G, Yang Z, Lu W, Zhang R, Huang Q, Tian M, Li L, Liang D, Li C. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials 30(10):1928-36, 2009. PMCID: PMC2745599.
42. Thapa P, Zhang G, Xia C, Gelbard A, Overwijk WW, Liu C, Hwu P, Chang DZ, Courtney A, Sastry JK, Wang PG, Li C, Zhou D. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing energy. Vaccine 27(25-26):3484-8, 2009. PMID: 19200815.
43. Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, Lu W, Tian M, Gelovani JG, Qiao A, Li C. Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology 20(16):165101, 2009. PMCID: PMC2745816.
44. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 206(7):1603-14, 2009. PMCID: PMC2715090.
45. Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C. Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres. Clin Cancer Res 15(3):876-86, 2009. PMCID: PMC2727065.
46. Wang W, Shao R, Wu Q, Ke S, McMurray J, Lang FF, Charnsangavej C, Gelovani JG, Li C. Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide. Mol Imaging Biol 11(6):424-33, Nov-Dec, 2009. PMCID: PMC3435882.
47. Frank SJ, Stafford RJ, Bankson JA, Li C, Swanson DA, Kudchadker RJ, Martirosyan KS. A vovel MRI marker for prostate brachytherapy. Int J Radiat Oncol Biol Phys 71:5-8, 2008. PMID: 18406882.
48. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7(6):1730-9, 2008. PMCID: PMC2727060.
49. Zhang G, Zhang R, Wen X, Li L, Li C. Micelles based on biodegradable poly(L-glutamic acid)-b-polylactide with paramagnetic Gd ions chelated to the shell layer as a potential nanoscale MRI-visible delivery system. Biomacromolecules 9(1):36-42, 2008. PMCID: PMC2547341.
50. Li M-L, Oh J-T, Xie X, Ku G, Wang W, Li C, Lungu G, Stoica G, Wang LV. Simultaneous molecular and hypoxia imaging of brain tumors in vivo using spectroscopic photoacoustic tomography. Proceedings of the IEEE 96:481-9, 2008.
51. Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C. Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping. Invest Radiol 42(8):569-78, 8/2007. PMCID: PMC2746745.
52. Melancon MP, Wang W, Wang Y, Shao R, Ji X, Gelovani JG, Li C. A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier. Pharm Res 24(6):1217-24, 2007. PMCID: PMC2746742.
53. Zou C, Brewer M, Cao X, Zhang R, Lin J, Deng Y, Li C. Antitumor activity of 4-(N-hydroxyphenyl)retinamide conjugated with poly(L-glutamic acid) against ovarian cancer xenografts. Gynecol Oncol 107(3):441-9, 2007. PMID: 17854871.
54. Ji X, Shao R, Elliott AM, Stafford RJ, Esparza-Coss E, Liang G, Luo ZP, Park K, Markert JT, Li C. Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy. J Phys Chem, C 111(17):6245, 2007. PMCID: PMC2822349.
55. Yang Z, Zheng S, Harrison WJ, Harder J, Wen X, Gelovani JG, Qiao A, Li C. Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: synthesis, characterization, and dual nuclear/optical imaging. Biomacromolecules 8(11):3422-8, 2007. PMCID: PMC2542943.
56. Jackson EF, Esparza-Coss E, Wen X, Ng CS, Daniel SL, Price RE, Rivera B, Charnsangavej C, Gelovani JG, Li C. Magnetic resonance imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids. Int J Radiat Oncol Biol Phys 68(3):830-8, 2007. PMCID: PMC1997292.
57. Zhu G, Cao X, Chang JY, Milas L, Wallace S, Li C. Polymeric retinoid prodrug PG-4HPR enhances the radiation response of lung cancer. Oncol Rep 18(3):645-51, 2007. PMID: 17671714.
58. Park K, Liang G, Ji X, Luo ZP, Li C, Croft M, Markert JT. Structural and magnetic properties of gold and silica doubly coated γ-Fe2O3 nanoparticles. J Phys Chem, C 111:18512–19, 2007.
59. Shao R, Xiong C, Wen X, Gelovani JG, Li C. Targeting phosphatidylserine on apoptotic cells with phages and peptides selected from a bacteriophage display library. Mol Imaging 6(6):417-26, 2007. PMID: 18053412.
60. Oh SH, Lee OH, Schroeder CP, Oh YW, Ke S, Cha HJ, Park RW, Onn A, Herbst RS, Li C, Lee HY. Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition. Mol Cancer Ther 5(11):2685-95, 2006. PMID: 17121915.
61. Li C, Wang W, Wu Q, Ke S, Houston J, Sevick-Muraca E, Dong L, Chow D, Charnsangavej C, Gelovani JG. Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe. Nucl Med Biol 33(3):349-58, 2006. PMID: 16631083.
62. Wang W, McMurray JS, Wu Q, Campbell ML, Li C. Convenient solid-phase synthesis of diethylenetriaminepenta-acetic acid (DTPA)- conjugated cyclic RGD peptide analogues. Cancer Biother Radiopharm 20:547-56, 2005.
63. Kwon S, Ke S, Houston JP, Wang W, Wu QP, Sevick-Muraca EM, Li, C. Dose-dependent uptakes of an RGD-fluorescent dye-targeted to avb3 receptor expressed in Kaposi’s sarcoma. Mol Imaging 4:75-88, 2005.
64. Hwang K, Houston JP, Rasmussen JC, Joshi A, Ke S, Li C, Sevick-Muraca EM. Improved excitation light rejection enhances small-animal fluorescent optical imaging. Mol Imaging 4:194-204, 2005.
65. Wang W, Wu Q, Pasuelo M, McMurray JS, Li C. Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization. Bioconjug Chem 16(3):729-34, 2005. PMID: 15898744.
66. Houston JP, Ke S, Wang W, Sevick-Muraca EM, Li C. Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe. J Biomed Opt 10:54010, 2005.
67. Gurfinkel M, Ke S, Wang W, Sevick-Muraca EM, Li, C. Quantifying molecular specificity of avb3 integrin-targeted optical contrast agents with dynamic optical imaging. J Biomed Opt 10:1-9, 2005.
68. Ke S, Wen X, Wu QP, Wallace S, Charnsangavej C, Stachowiak AM, Stephens CL, Abbruzzese JL, Podoloff DA, Li C. Imaging taxane-induced tumor apoptosis using PEGylated, 111In-labeled annexin V. J Nucl Med 45:108-15, 2004.
69. Wang W, Ke S, Wu Q, Charnsangavej C, Gurfinkel M, Gelovani JG, Abbruzzese JL, Sevick-Muraca EM, Li C. Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. Mol Imaging 3:343-51, 2004.
70. Tansey W, Ke S, Cao XY, Pasuelo MJ, Wallace S, Li C. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J Control Release 94:39-51, 2004.
71. Wen X, Jackson EF, Price RE, Kim EE, Wu Q, Wallace S, Charnsangavej C, Gelovani JG, Li C. Synthesis and characterization of poly(L-glutamic acid) gadolinium chelate: a new biodegradable MRI contrast agent. Bioconjug Chem 15:1408-15, 2004.
72. Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC. Paclitaxel-induced inactivation of p70 S6 kinase is associated with phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 22:484-497, 1/2003.
73. Wen X, Wu QP, Ke S, Wallace S, Charnsangavej C, Huang P, Liang D, Chow D, Li C. Improved radiolabeling of PEGylated protein: PEGylated annexin V for noninvasive imaging of tumor apoptosis. Cancer Biother Radiopharm 18:819-27, 2003.
74. Ke S, Wen X, Gurfinkel M, Charnsangavej C, Wallace S, Sevick-Muraca EM, Li C. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res 63:7870-5, 2003.
75. Milas L, Mason KA, Hunter N, Li C, Wallace S. Poly(L-glutamic acid)-paclitaxel conjugate is a potent enhancer of tumor radiocurability. Int J Radiat Oncol Biol Phys 55:707-12, 2003.
76. Vega J, Ke S, Fan Z, Wallace S, Charsangavej C, Li C. Targeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(L-glutamic acid) through a polyethylene glycol spacer. Pharm Res 20:826-32, 2003.
77. Auzenne E, Donato NJ, Li C, Leroux E, Price RE, Farquhar D, Klostergaard J. Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian carcinoma. Clin Cancer Res 8:573-81, 2002.
78. Wen X-X, Wu Q-P, Ke S, Ellis L, Charnsangavej C, Delpassand AS, Wallace S, Li C. Conjugation with (111)In-DTPA-poly(ethylene glycol) improves imaging of anti-EGF receptor antibody C225. J Nucl Med 42:1530-1537, 2001.
79. Zou Y, Wu QP, Tansey W, Chow D, Hung MC, Charnsangavej C, Wallace S, Li C. Effectiveness of water soluble poly(L-glutamic acid)-camptothecin conjugate against resistant human lung cancer xenografted in nude mice. Int J Oncol 18:331-6, 2001.
80. Wen X, Wu QP, Lu Y, Fan Z, Charnsangavej C, Wallace S, Chow D, Li C. Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains. Bioconjug Chem 12:545-53, 2001.
81. Ke S, Milas L, Charnsangavej C, Wallace S, Li C. Potentiation of radioresponse by polymer-drug conjugates. J Control Release 74:237-42, 2001.
82. Li C, Newman RA, Wu QP, Ke S, Chen W, Hutto T, Kan Z, Brannan MD, Charnsangavej C, Wallace S. Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor. Cancer Chemother Pharmacol 46:416-22, 2000.
83. Oldham EA, Li C, Ke S, Wallace S, Huang P. Comparison of action of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in human breast cancer cells. Int J Oncol 16:125-32, 2000.
84. Wallace S, Kan Z, Li C. Hepatic chemoembolization: clinical and experimental correlation. Acta Gastroenterol Belg 63:169-73, 2000.
85. Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Potentiation of ovarian OCa-1 tumor radioresponse by poly (L-glutamic acid)-paclitaxel conjugate. Int J Radiat Oncol Biol Phys 48:1119-26, 2000.
86. Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin Cancer Res 6:2829-34, 2000.
87. Li C, Price JE, Milas L, Hunter NR, Ke S, Yu DF, Charnsangavej C, Wallace S. Antitumor activity of poly(L-glutamic acid)-paclitaxel on syngeneic and xenografted tumors. Clin Cancer Res 5:891-7, 1999.
88. Multani AS, Li C, Ozen M, Imam AS, Wallace S, Pathak S. Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity. Oncol Rep 6:39-44, 1999.
89. Inoue T, Li C, Yang DJ, Higuchi T, Oriuchi N, Yu D, Milas L, Hunter N, Wallace S, Kim EE, Podoloff DA. Evaluation of In-111 DTPA-paclitaxel scintigraphy to predict response on murine tumors to paclitaxel. Ann Nucl Med 13:169-74, 1999. PMID: 10435377.
90. Li C, Yu DF, Newman RA, Cabral F, Stephens LC, Hunter N, Milas L, Wallace S. Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res 58:2404-9, 1998.
91. Multani AS, Li C, Ozen M, Yadav M, Yu DF, Wallace S, Pathak S. Paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line. Anticancer Res 17:4269-74, 1997.
92. Li C, Yu D-F, Inoue T, Yang DJ, Milas L, Hunter NR, Kim, EE, Wallace S. Synthesis, biodistribution and imaging properties of indium-111-DTPA-paclitaxel in mice bearing mammary tumors. J Nucl Med 38(7):1042-1047, 1997. PMID: 9225788.
93. Kim CG, Yang DJ, Kim EE, Cherif A, Kuang LR, Li C, Tansey W, Liu CW, Li SC, Wallace S, Podoloff DA. Assessment of tumor cell proliferation using [18F]fluorodeoxyadenosine and[18F]fluoroethyluracil. J Pharm Sci 85:339-44, 1996. PMID: 8699341.
94. Li C, Yu D, Kan Z, Yang DJ, Tansey W, Kuang LR, Wallace S. Biodistribution of cyclic carbonate of ioxilan: a radiopaque particulate macrophage imaging agent. Acad Radiol 3:500-6, 1996. PMID: 8796708.
95. Li C, McCuskey P, Yu D-F, Yang DJ, Kan Z-X, Wallace S. Development of biodegradable Ioxilan carbonate particles for contrast enhancement of the liver in computed tomography scanning: toxicity assessment. Acad Radiol 3:S001-S003, 1996.
96. Li C, Yu D-F, Inoue T, Yang DJ, Milas L, Hunter NR, Wallace S. Synthesis and evaluation of polyethylene glycol Taxol conjugate as a paclitaxel prodrug. Anti-Cancer Drugs 7:642-648, 1996.
97. Yang DJ, Wallace S, Cherif A, Li C, Gretzer MB, Kim EE, Podoloff DA. Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia. Radiology 194:795-800, 1995. PMID: 7862981.
98. Yang DJ, Kuang LR, Li C, Kan Z, Wallace S. Computed tomographic liver enhancement with poly(d,1-lactide)-microencapsulated contrast media. Invest Radiol 29:S267-70, 1994. PMID: 7928253.
99. Yang DJ, Li C, Nikiforow S, Gretzer MB, Kuang LR, Lopez MS, Vargas K, Wallace S. Diagnostic and therapeutic potential of poly(benzyl L-glutamate). J Pharm Sci 83:328-31, 1994. PMID: 7515964.
100. Li C, Yang DJ, Nikiforow S, Tansey W, Kuang LR, Wright KC, Wallace S. Formation and characterization of cisplatin-loaded poly(benzyl l-glutamate) microspheres for chemoembolization. Pharm Res 11:1792-9, 1994. PMID: 7534920.
101. Yang DJ, Li C, Kuang LR, Price JE, Buzdar AU, Tansey W, Cherif A, Gretzer M, Kim EE, Wallace S. Imaging, biodistribution and therapy potential of halogenated tamoxifen analogues. Life Sci 55:53-67, 1994. PMID: 8015349.
102. Li C, McCuskey P, Kan Z, Yang DJ, Wright KC, Wallace S. In vivo and electron microscopic studies of rat liver after intravenous injection of polyamino acid microspheres. J Biomed Mater Res 28:881-90, 1994. PMID: 7527046.
103. Li C, Kan Z, Yang DJ, Kuang LR, Liu CW, Wright KC, Wallace S. Preparation, characterization, and evaluation of ioxilan carbonate particles for computed tomography contrast enhancement of liver. Invest Radiol 29:1006-13, 1994. PMID: 7890508.
104. Li C, Yang DJ, Kuang L-R, Wallace S. Polyamino acid microspheres: preparation, characterization, and distribution after intravenous injection in rats. Int J Pharm 94:143-152, 1993.
105. Yang D, Kuang LR, Cherif A, Tansey W, Li C, Lin WJ, Liu CW, Kim EE, Wallace S. Synthesis of [18F]fluoroalanine and [18F]fluorotamoxifen for imaging breast tumors. J Drug Target 1:259-67, 1993. PMID: 8069568.
106. Silver FH, Marks M, Kato YP, Li C, Pulapura S, Kohn J. Tissue compatibility of tyrosine-derived polycarbonates and polyiminocarbonates: an initial evaluation. J Long-Term Effects Med Impl 1:329-346, 1992. PMID: 10171118.
107. Pulapura S, Li C, Kohn J. Structure-property relationships for the design of polyiminocarbonates. Biomaterials 11(9):666-78, 1990. PMID: 2090301.
108. Li C, Kohn J. Synthesis of poly(iminocarbonates): degradable polymers with potential applications as disposable plastics and as biomaterials. Macromolecules 22(5):2029-2036, 1989.

Invited Articles

1. Melancon MP, Stafford RJ, Li C.. Challenges to effective cancer nanotheranostics. J Control Release 164(2):177-82, 2012. PMCID: PMC3504179.
2. Li C. Image-guided photonic energy deposition for cancer ablation and drug delivery. Curr Med Imaging Rev 8:267-277, 2012.
3. Melancon MP, Li C. Multifunctional synthetic poly(L-glutamic acid)-based cancer therapeutic and imaging agents. Mol Imaging 10(1):28-42, 2/2011. PMCID: PMC3435883.
4. Melancon MP, Zhou M, Li C. Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Acc Chem Res 44(10):947-956, 2011. PMCID: PMC3196765.
5. Melancon M, Lu W, Li C. Gold-Based Magneto/Optical Nanostructures: Challenges for In Vivo Applications in Cancer Diagnostics and Therapy. Mater Res Bull 34:415-421, 2009.
6. Li C, Wallace S. Polymer-drug conjugates: Recent development in clinical oncology. Adv Drug Deliv Rev 60:886-98, 2008.
7. Belhocine TZ, Tait JF, Vanderheyden J-L, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V (Perspectives). J Proteome Res 3:345-349, 2004.
8. Wen XX, Cao XY, Paseulo MJ, Wendt R, Li C. Polymeric radiotracers in nuclear imaging. Curr Drug Deliv 1:377-384, 2004.
9. Belhocine T, Steinmetz N, Li C, Green A, Blankenberg FG. The imaging of apoptosis with radiolabeled Annexin V: Optimal timing for clinical feasibility. Tech Cancer Res Treat 3:23-32, 2004.
10. Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM. Near-infrared fluorescence optical imaging and tomography. Dis Markers 19(2-3):107-121, 2004, 2003. PMID: 15096708.
11. Li C. Poly(L-glutamic acid)-anticancer drug conjugates. Adv Drug Deliv Rev 54:695-713, 2002.
12. Li C, Newman R, Wallace S. Reformulating paclitaxel. Science & Medicine 6:38-47, 1999.

Abstracts

1. Wen XX, DeLyria ES, Huang Q, Thapa P, Zhou DP, Li C. Antitumor efficacy and biodistribution of poly-L-glutamic acid conjugated CpG in mice bearing B16 melanoma. World Molecular Imaging Congress, San Diego, CA, 9/2011.
2. Zhou M, Zhang R, Huang M, Melancon MP, Song S, Li C. A New chelator-free multifunctional semiconductor nanoparticle platform for simultaneous µPET/CT imaging and photothermal-radiotherapy. Gordon Research Conferences-Cancer Nanotechnology, Waterville, ME, 7/2011.
3. Xiong CY, Song SL, Li C. μPET imaging of EphA2 and EphB4 receptors in ovarian cancer xenografts using 64Cu-labeled YSA-TNYL heterodimer. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
4. Song SL, Zhou M, Ku G, Flores-II L, Huang Q, Gelovani J, Li C. 64CuS nanoparticles as a dual PET/CT and photoacoustic imaging agent for sentinel lymph nodes mapping. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
5. Zhou M, Zhang R, Huang M, Melancon MP, Song SL, Li C. A New chelator-free multifunctional [64Cu]-CuS nanoparticle platform for simultaneous µPET/CT imaging and radiotherapy. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
6. Zhang R, Lu W, Wen XX, Huang Q, Huang M, Yang Z, Zhou M, Li C. Annexin A5-functionalized nanoparticles for in vivo dual modality imaging of apoptosis. Society of Nuclear Medicine 2011 Annual Meeting, Annexin A5-functionalized nanoparticles for in viv, 6/2011.
7. Huang M, Xiong CY, Zhang R, Lu W, Huang Q, Flores II LG, Gelovani J, Li C. EphB4-binding peptide for dual modality µPET/CT and optical imaging of glioblastoma in orthotopic xenograft models. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
8. Huang M, Zhou M, Ku G, Battula VL., Andreeff M, Li C. Human mesenchymal stem cells loaded with [64Cu]CuS nanoparticles for dual-modality imaging of stem cell distribution in vivo. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
9. Shaoli Song SL, Xiong CY, Ku G, Li C. Novel apoptosis imaging biomarker early predicts chemotherapy response in preclinical models: a comparative study with 18F-FDG PET. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
10. Ku G, You J, Zhang GD, Shen HF, Li C. Optical absorption and scattering comparison of various nanoparticles in near infrared by photoacoustic imaging and spectrophotometer. Society of Nuclear Medicine 2011 Annual Meeting, San Antonio, TX, 6/2011.
11. Gupta S, Javadi S, Ozkan E, You J, Wright KC, Joseph E, Li C, Wallace MJ. Laser activated release of paclitaxel from biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intra-arterially into liver tumor in an animal model. J Vasc Interv Radiol Supplement 22(3S):S11, 3/2011.
12. Gupta S, Shaw C, Tian M, Lu W, Nazario J, Joseph E, Zhang R, Wright KC, Dixon K, Li C. Tumoral uptake of hollow gold nanospheres after intra-arterial and intravenous administration in an animal liver tumor model. J Vasc Interv Radiol Supplement 22(3S):S74, 3/2011.
13. Zhao J, Song S, You J, Li C. γ-Imaging of systemically administered biodegradable, core-crosslinked polymeric micelles as a potential drug carrier. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
14. Song S, Xiong C , Zhou M, Lu W, Huang Q, Ku G, Ni Y, Li C. µPET imaging of tumor necrosis induced by photothermal ablation therapy with 64Cu-hypericin. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
15. Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A new chelator-free multifunctional [64Cu]-CuS nanoparticle for simultaneous µPET/CT imaging and photothermal ablation therapy. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
16. Zhang R, Lu W, Wen X-X, Huang Q, Huang M, Yang Z, Zhou M, Li C. Annexin V-functionalized nanoparticles for dual modality imaging of apoptosis. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
17. Zhang G-D, Melancon MP, Zhang R, You J, Li C. Biodegradable polymeric MRI agent: Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
18. Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Stafford RJ, Ku G, Gelovani JG, Li C. Brain tumor theranostics: photoacoustic tomography-guided thermal ablation mediated with targeted HAuNS. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
19. Ku G, Zhou M, Zhong M, Hazle JD, Gelovani JG, Li C. Deeply penetrating photoacoustic tomography in biological tissues using CuS nanoparticles as optical contrast agents. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
20. Xiong C, Huang M, Zhang R, Song S, Lu W, Flores II L, Gelovani JG, Li C. In vivo µPET/CT imaging of EphB4 receptors using 64Cu-labeled peptides. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
21. Melancon MP, Lu W, Elliott AM, Taylor B, Huang Q, Ng C, Hazle JD, Li C, Stafford RJ. MRI-guided thermal ablation using multimodality, multifunctional SPIO@Au nanoshell targeted to epidermal growth factor receptors. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
22. Xiong C, Song S, Lu W, Zhang R, Wen X-X, Li C. Peptide-based imaging agents targeting phosphatidylserine for the detection of apoptosis. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
23. Lu W, Zhang G-D, Zhang R, Flores II L, Huang Q, Gelovani JG, Li C. Photothermal transfection of siRNA under the guidance of PET/CT imaging using hollow gold nanospheres. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
24. Xiong C, Li C. Towards improved pharmacokinetic profiles and increased metabolic stability of 64Cu-labeled peptides with high binding affinity to EphB4 receptors for PET. World Molecular Imaging Congress, Kyoto, Japan, 9/2010.
25. Li C, Wen X-X, Lu W, Thapa P, Hwu P, Zhou DP. Enhanced antitumor effect of water-soluble polymer-conjugated TLR9 ligand CpG ODN-2216 in a mouse model of melanoma. Keystone Symposia-Molecular and Cellular Biology of Immune Escape, Keystone, CO, 2/2010.
26. Elliott AM, Shetty A, Melancon MP, Ji X-J, Taylor B, Hazle JD, Li C, Stafford RJ. MRTI evaluation of SPIO core gold coated nanoshells for thermal therapy and as T2* contrast agent. American Society of Mechanical Engineering (ASME) First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010), Houston, TX, 2/2010.
27. Zhang G-D, Melancon MP, Zhang R, Wen X-X, Li C. Synthesis and evaluation of biodegradable and nonionic polymeric MRI agent: Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd. 10th US-Japan Symposium on Drug Delivery Systems, Lahaina, HI, 12/2009.
28. Lu W, Huang Q, Li C. Enhanced photoacoustic tomography of mouse brain vasculature using hollow gold nanoshells as a novel optical contrast agent. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, Los Angeles, CA, 11/2009.
29. Lu W, Melancon MP, Huang Q, Thapa P, Wen X-X, Xiong C-Y, Zhou D-P, Ng C, Li C. Mechanism for the uptake of long circulating biodegradable polymeric magnetic resonance contrast agent in tumor necrotic area. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, Los Angeles, CA, 11/2009.
30. Zhou M, Zhang R, Li C. A new chelator-free multifunctional [64Cu]-CuS nanoparticles for simultaneous µPET/CT imaging and photothermal ablation therapy. 4th Annual NCI Alliance for Nanotechnology in Cancer Investigators Meeting, Manhattan Beach, CA, 10/2009.
31. You J, Zhang Z, Li C. Hollow gold nanospheres for near-infrared light-triggered drug release and their antitumor activity. 4th Annual NCI Alliance for Nanotechnology in Cancer Investigators Meeting, Manhattan Beach, CA, 10/2009.
32. Zhang R, Lu W, Li C. Annexin A5-conjugated polymeric micelles for multimodal detection of apoptosis. 4th Annual NCI Alliance for Nanotechnology in Cancer Investigators Meeting, Manhattan Beach, CA, 2009.
33. Zhang G, Lu W, Zhang R, Yang Z, Huang Q, Li C. Gold nanoparticles coated by PEG with thioctic amides terminal: their features in vitro and fates in tumor-xenografted mice. MRS Fall Symposium, Boston, MA, 12/2008.
34. Wen X-X, Zhang R, Lyu M-A, Huang Q, Gelovani JG, Rosenblum MG, Li C. Biodistribution and pharmacokinetics of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B-cell lymphoma. World Molecular Imaging Congress, Nice, France, 9/2008.
35. Xiong C-Y, Lu W, Yang Z, Zhang R, Tong W, Gelovani JG, Li C. Cell-permeable 99mTc(CO3)-labeled fluorogenic caspase substrate for dual modality detection of apoptosis. World Molecular Imaging Congress, Nice, France, 9/2008.
36. Melancon MP, Yang Z, Wen X-X, Lu W, Tong W, Gelovani JG, Li C. Extravasation of dual magneto-optical polymeric contrast agent into the lymph is enhanced by treatment with poly(glutamate)-Taxol conjugate. World Molecular Imaging Congress, Nice, France, 9/2008.
37. Melancon MP, Shetty A, Huang Q, Williams R, Wen, X-X, Elliott AM, Gelovani JG, Stafford RJ, Li C. Hollow gold nanospheres (HGNSs)-mediated hyperthermia causes increased vascular perfusion in tumors for enhanced delivery of polymeric drug. World Molecular Imaging Congress, Nice, France, 9/2008.
38. Shao R-P, Xiong, C-Y, Lu W, Wen X-X, Gelovani JG, Li C. Identification of a novel peptide targeting PDGF receptors for molecular imaging and therapy. World Molecular Imaging Congress, Nice, France, 9/2008.
39. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Shetty A, Stafford J, Olsen T, Gelovani JG, Zhang JZ, Li, C. In vitro and in vivo targeting of hollow gold nanospheres (HGNSs) directed at EGF receptors. World Molecular Imaging Congress, Nice, France, 9/2008.
40. Lu W, Xiong C-Y, Zhang G-D, Huang Q, Zhang R, Gelovani JG, Zhang JZ, Li C. Monitoring targeted photothermal ablation of melanoma mediated by hollow gold nanospheres using micro[F-18]FDG-PET. World Molecular Imaging Congress, Nice, France, 9/2008.
41. Lu W, Huang Q, Gelovani JG, Oraevsky A, Ku G, Wang L-H, Li C. Photoacoustic tomography imaging of mouse brain vasculature with long-circulating hollow gold nanospheres. World Molecular Imaging Congress, Nice, France, 9/2008.
42. Melancon MP, Elliott AM, Shetty A, Taylor B, Ji X-J, Huang Q, Gelovani JG, Stafford RJ, Li C. Theragnostics with magnetic gold nanoshells: photothermal therapy and T2* magnetic resonance imaging. World Molecular Imaging Congress, Nice, France, 9/2008.
43. Stafford RJ, Shetty A, Elliott, AM, Swartz J, Melancon MP, Li C, Hazle JD. Characterization of gold nanoshells for thermal therapy using MRI. The 2008 John S. Laughlin Science Council Research Symposium, American Association of Physicists in Medicine 50th Annual Scientific Meeting, Houston, TX, 7/2008.
44. Lu W, Huang Q, Xiong C-Y, Zhang G-D, Zhang R, Li C. Targeted photothermal ablation effect of hollow gold nanoshells in tumor-bearing mice. 35th Annual Meeting of the Controlled Release Society, New York, NY, 7/2008.
45. Elliott AM, Shetty A, Melancon MP, Ji X-J, Taylor B, Hazle JD, Li C, Stafford RJ. MRTI Evaluation of SPIO core gold coated nanoshells for thermal therapy and as T2* contrast agent. 17th Annual Meeting International Society for Magnetic Resonance in Medicine (ISMRM), Toronto, Canada, 5/2008.
46. Elliott AM, Hazle JD, Li C, Stafford RJ. Modeling laser thermal therapy output for nanoshell heating using a natural coordinate system. PHOTONICS WEST 2008 & BIOS, San Jose, CA, 1/2008.

Book Chapters

1. Li C, Zhang JZ. Hollow gold nanospheres (HAuNS). In: Encyclopedia of Nanotechnology. Springer Verlag GmbH,: Heidelberg, Germany, 2012.
2. Lu W, Melancon MP, Li C. Theranostic applications of gold core-shell structured nanoparticles. In: Theranostic Nanoplatform-Based Molecular Imaging. Ed(s) X Chen. John Wiley & Sons, Inc. Hoboken, NJ, 2012.
3. Melancon MP, Wen X-X, Zhang G-D, Li C. Multi-functional, multi-modality cancer imaging with water- soluble synthetic polymers. In: Nanoimaging. Ed(s) B Goinss, W Phillips. Pan Stanford Publishing Pte Ltd: Singapore, 171-195, 2011.
4. Melancon MP, Li C. Core-shell magnetic nanomaterials in medical diagnosis and therapy. In: Magnetic Nanomaterials. Ed(s) CSSR Kumar. Wiley-VCH Verlag GmbH & Co. Weinheim, Germany, 259-290, 2009.
5. Zhang G-D, Jackson E, Wallace S, Li C. Poly (L-glutamic acid): efficient carrier of cancer therapeutics and diagnostics. In: Nanotechnology for Cancer Therapeutics. Ed(s) MM Amiji: Boca Raton, FL, 185-199, 2007.
6. Yang DJ, Li C, Kim EE. Imaging of anticancer drugs, response and prognosis. In: Targeted Imaging in Oncology. Ed(s) EE Kim, DJ Yang. Springer-Verlag: New York, 185-200, 2001.
7. Li C, Jackson E. Polymer-based compounds for targeted imaging. In: Targeted Imaging in Oncology. Ed(s) EE Kim, DJ Yang. Springer-Verlag: New York, 111-121, 2001.
8. Singer J, De Vries P, Bhatt R, Tulinsky J, Klein P, Li C, Milas L, Lewis RA, Wallace S. Conjugation of camptothecins to poly(L-glutamic acid). In: The Camptothecins: Unfolding Their Anticancer Potential. Ed(s) JG Liehr, BC Giovanella, C Verschraegen. The New York Academy of Sciences: New York, 136-150, 2000.
9. Yang DJ, Gretzer MB, Kuang L-R, Cherif A, Li C, Diaz MF, Liu C-W, Emran A, Tansey W, Wallace S. Radiolabeled tamoxifen analogues for imaging breast cancer with SPECT. In: Chemists' View of Imaging Center. Ed(s) AM Emran. Plenum Publishing Corporation: New York, 513-526, 1995.
10. Yang DJ, Wallace S, Kuang L-R, Li C, Cherif A, Kan Z-X, McCuskey P, Wright KC. Microencapsulation, tamoxifen analogues and in vivo microscopy for tumor targeting. In: Cancer Treatment, An Update. Ed(s) P Banzet, JF Holland, D Khayat, M Weil. Springer-Verlag: Paris, 817-819, 1994.
11. Yang DJ, Kuang L-R, Li C, Liu C-W, Tsai T, Lin WJ, Tansey W, Nikiforow S, McCuskey P, Kan Z-X, Wright KC, Wallace S. Evaluation of poly(dl-lactide) encapsulated radiopaque microspheres. In: Polymeric Delivery System. Ed(s) M El-Nokaly. American Chemistry Society: Washington DC, 372-382, 1992.

Grant & Contract Support

Title: PET and MRI-Guided Photothermal-Chemotherapy in Hepatocellular Carcinoma
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 4/1/2014 - 3/31/2019
 
Title: PET Guided PTA-Chemotherapy of Unresectable Liver Tumors
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2014 - 3/31/2019
 
Title: Targeted delivery of cyclopamine by biodegradable core-crosslinked polymeric micelles for radio-chemotherapy of pancreatic cancer
Funding Source: Viragh Foundation
Role: Principal Investigator
Duration: 7/1/2012 - 6/30/2017
 
Title: Molecular imaging of combined EphB4 RNAi and Bevacizumab therapy in ovarian cancer
Funding Source: MDACC
Role: Principal Investigator
Duration: 3/1/2012 - 2/28/2014
 
Title: Radio-photothermal nanotherapy for anaplastic thyroid cancer (Head and Neck Cancer SPORE)
Funding Source: NIH/NCI
Role: Principal Investigator-Developmental Research Project
Principal Investigator: Myers
Duration: 8/1/2011 - 7/30/2013
 
Title: Toward individualized breast cancer therapy: Leveraging molecular medicine with multistage vector technology
Funding Source: USAMRAA
Role: Principal Investigator-MDACC
Principal Investigator: Ferrari
Duration: 4/1/2011 - 2/28/2014
 
Title: Simultaneous photothermal ablation RNAi therapy of melanoma (Melanoma SPORE)
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 9/15/2010 - 8/31/2012
 
Title: Texas Center for Cancer Nanomedicine (TCCN)
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Gorenstein, Ferrari, Sood, Lopez
Duration: 9/1/2010 - 8/31/2015
 
Title: Chemopreventive effect of fish oil derived EPA in lung cancer
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Yang, PI
Duration: 7/1/2010 - 4/30/2013
 
Title: Characterizing and targeting replication stress response defects in breast cancer
Funding Source: USAMRMC
Role: Collaborator
Principal Investigator: Lin
Duration: 3/1/2010 - 2/28/2015
 
Title: Subcellular localization of nanoparticles
Funding Source: NIH/NIGMS
Role: Principal Investigator-MDACC
Duration: 10/1/2009 - 8/31/2012
 
Title: Near-Infrared semiconductor nanocrystal for imaging guided surgery
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC
Principal Investigator: Qiao
Duration: 9/30/2009 - 5/15/2011
 
Title: Near-infrared fluorescence nanoparticles for targeted optical imaging
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/29/2009 - 9/28/2011
 
Title: Evaluation of antitumor efficacy of laser stimulated release of paclitaxel from nanoshell microspheres administered intra-arterially into liver tumor in an animal model
Funding Source: Mike Hogg Foundation
Role: Co-Investigator
Principal Investigator: Gupta
Duration: 1/1/2009 - 12/31/2009
 
Title: The medical nanovector research and development center of the Alliance for NanoHealth
Funding Source: DOD/TARTRC
Role: Principal Investigator
Duration: 8/29/2008 - 8/31/2012
 
Title: John S. Dunn Foundation for Imaging Sciences: Chemistry Laboratory
Funding Source: John S. Dunn
Role: Principal Investigator
Duration: 7/1/2007 - 6/30/2014
 
Title: Experimental cancer imaging research program (ECIRP)
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: Hazle
Duration: 3/26/2007 - 2/28/2012
 
Title: Near-infrared fluorescence nanoparticles for targeted optical imaging
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/29/2005 - 9/28/2010
 
Title: Site-selective introduction of DTPA-PEG to annexin V for enhanced nuclear imaging of tumor apoptosis
Funding Source: Mike Hogg Foundation
Role: Principal Investigator
Duration: 1/1/2005 - 1/1/2006
 
Title: Small animal fluorescence-enhanced optical imaging
Funding Source: NIH/NIBIB
Role: Co-Principal Investigator
Principal Investigator: Sevick-Muraca
Duration: 9/16/2003 - 9/15/2005
 
Title: Assessing angiogenesis by near-infrared imaging
Funding Source: NIH/NIBIB
Role: Principal Investigator
Duration: 8/1/2002 - 7/30/2008
 
Title: Prostate cancer SPORE
Funding Source: NIH/NCI
Role: Co-PI-Career Development Award
Principal Investigator: Logothetis and Lin
Duration: 7/31/2002 - 8/1/2004
 
Title: Development of macromolecular chemotherapeutics
Funding Source: Cell Therapeutics, Inc
Role: Co-Principal Investigator
Duration: 7/1/2002 - 6/30/2005
 
Title: Polymeric carriers for molecularly targeted diagnostic agents for near-infrared optical imaging
Funding Source: Texas Higher Education/Advanced Technology Program
Role: Principal Investigator
Duration: 1/1/2002 - 12/30/2003
 
Title: Targeted assessment of antiangiogenic therapy
Funding Source: NIH/NCI
Role: PI-Development Research Award
Principal Investigator: Abbruzzese
Duration: 7/1/2001 - 6/30/2006
 
Title: Radiation induced chemosensitization: potentiation of antitumor activity of polymer-drug conjugate
Funding Source: USAMRMC Department of Defense
Role: Principal Investigator
Duration: 3/1/2000 - 2/1/2003
 
Title: Development of poly(L-glutamic acid)-Phase I
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Wallace
Duration: 4/15/1999 - 3/31/2000
 
Title: Mechanisms of action of a highly efficacious PGA-Taxol conjugate
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/1997 - 6/30/2002

Last updated: 6/26/2014