Chun Li, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
About Dr. Li
Research activities in Dr. Chun Li’s laboratory are primarily focused on two areas: 1) the development of targeted imaging probes for noninvasive characterization of molecular events associated with tumor progression and regression and 2) the development of novel drug-delivery systems for selective delivery of diagnostic and therapeutic agents. Molecular imaging probes used in nuclear, optical, and magnetic resonance imaging modalities are designed to enhance the sensitivity and selectivity of early tumor detection, tumor-marker profiling, and the monitoring of early treatment responses. Targeted drug delivery, on the other hand, uses nanometric drug carriers to selectively deliver anticancer agents to the tumor to maximize their therapeutic efficacy and minimize their toxic side effects to the normal tissues. Their long-term goal is to apply the “seek and treat” strategy in the development of targeted imaging/therapeutic agents that will eventually be translated to the clinic to improve the management of cancer through early tumor detection and individualized therapy.
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Present Title & Affiliation
Primary Appointment
Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Graduate Faculty, Division of Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX
Adjunct Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX
Research Interests
Molecular Imaging Probes, Drug Delivery Systems, Nanotechnology Research activities in the Dunn Foundation Chemistry Laboratory for Imaging Sciences are primarily focused on two areas: The development of targeted imaging probes for noninvasive characterization of molecular events associated with tumor progression and regression.
The development of novel drug-delivery systems for selective delivery of diagnostic and therapeutic agents. Molecular imaging probes used in nuclear, optical and magnetic resonance imaging modalities are designed to enhance the sensitivity and selectivity of early tumor detection, tumor-marker profiling, and the monitoring of early treatment responses. Targeted drug delivery, on the other hand, uses nanometric drug carriers to selectively deliver anticancer agents to the tumor to maximize their therapeutic efficacy and minimize their toxic side effects to the normal tissues.
Our long-term goal is to apply the "see-and-treat" strategy in the development of targeted imaging/therapeutic agents that will eventually be translated to the clinic to improve the management of cancer through early tumor detection and individualized therapy.
Education & Training
Degree-Granting Education
| 1991 | Rutgers-The State University of New Jersey, New Brunswick, NJ, USA, PHD, Chemistry |
| 1983 | Peking University, CHN, BS, Chemistry |
Postgraduate Training
| 1991-1993 | Research Associate, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Adjunct Professor, Department of Biomedical Engineering and Nanomedicine, The University of Texas Health Science Center at Houston, Houston, TX, 2011 - 2016
Adjunct Professor, Department of PET Center, Zhejiang University, Hangzhou, 2010 - 2016
Adjunct Associate Professor, Department of Dept. of Bioengineering, Rice University, Houston, TX, 2005 - 2007
Adjunct Associate Professor, Department of Dept. of Chemical Engineering, Texas A&M University, College Station, TX, 2002 - 2005
Associate Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2000 - 2003
Assistant Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 1994 - 2000
Instructor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 1993 - 1994
Other Appointments/Responsibilities
President, Chinese American Society of Nuclear Medicine and Molecular Imaging (CASNMMI), Philadelphia, PA, 2019 - 2021
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. An optimized bioassay for screening combined anticoronaviral compounds for efficacy against feline infectious peritonitis virus with pharmacokinetic analyses of GS-441524, Remdesivir, and molnupiravir in cats. Viruses 14(11):2429, 2022. PMID: 36366527.
- Lu Y, Li C. Incidental findings of coexisting metastatic pancreatic cancer in patients with prostate cancer on 18F-prostate-specific membrane antigen PET/CT. Clin Nucl Med 47(12):1103-1104. e-Pub 2022. PMID: 35835124.
- Peng H, Shen J, Long X, Zhou X, Zhang J, Xu X, Huang T, Xu H, Sun S, Li C, Lei P, Wu H, Zhao J. Local release of TGF-β inhibitor modulates tumor-associated neutrophils and enhances pancreatic cancer response to combined irreversible electroporation and immunotherapy. Adv Sci published by Wiley-VCH GmbH 9(10):e2105240, 2022. PMID: 35128843.
- Lincha VR, Zhao J, Wen X, Xiong C, Chow DSL, Li C. A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. Int J Pharm 601:120523 (1-10), 2021. PMID: 33775721.
- Yan VC, Pham CD, Yan MJ, Yan AJ, Khadka S, Arthur K, Ackroyd JJ, Georgiou DK, Roon LE, Bushman LR, Anderson PL, Li C, Muller FL. Pharmacokinetics of orally administered GS-441524 in dogs. bioRxiv, 2021. e-Pub 2021. PMID: 34100016.
- Huang YQ, Yang Z, Li F, Zhao H, Li C, Yu N, Hamilton D, Li Z. 64Cu/177Lu-DOTA-diZD, a small molecule-based theranostic pair for triple-negative breast cancer. Journal of Medicinal Chemistry 64(5):2705-2713, 2021. e-Pub 2021. PMID: 33646782.
- Cao QZ, Huang Q, Wang YA, Li C. Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1. Theranostics 11(7):3527-3539, 2021. PMID: 33537102.
- Lincha LR, Hsiao C-H, Zhao J, Li C, Chow D S-L. Sensitive and rapid UHPLC-MS/MS assay for simultaneous quantifications of calcipotriol and paclitaxel in rat whole blood and plasma samples. J Pharm Biomed Anal 192:113685, 2020. PMID: 33099115.
- Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang YA, Hsiao C-H H, Chow DS-L, Whitley EM, Li C, Gupta S. Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnology 11(1):6 (page 1-16), 2020. PMID: 34335988.
- Cao QZ, Wang WQ, Zhou M, Huang Q, Wen XX, Zhao J, Shi SX, Geng K, Li FE, Hatakeyama H, Xu CY, Piwnica-Worms D, Peng WY, Zhou DP, Sood AK, Li C. Induction of anti-tumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine 25:102169 (page 1-12), 2020. PMID: 32059873.
- Liu F, Guo X, Liu T, Xu X, Li N, Xiong C, Li C, Zhu H, Yang Z. Evaluation of pan-SSTRs targeted radioligand [64Cu]NOTA-PA1 using micro-PET imaging in xenografted mice. ACS Med Chem Lett 11(4):445-450, 2020. e-Pub 2020. PMID: 32292548.
- Xiong CY, Wen YF, Zhao J, Yin DK, Xu LY, Chelariu-Raicu A, Yao C, Leng XH, Liu JS, Chaudhari RR, Zhang SX, Sood AK, Li C. Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions. Scientific Reports 10(1):520, 2020. PMID: 31949258.
- Zhao J, Wen XX, Li TT, Shi SX, Wang YA, Li C. Concurrent injection of unlabeled antibodies allows positron emission tomography imaging of programmed cell death ligand 1 expression in an orthotopic pancreatic tumor model. ACS Omega 5(15):8474-8482, 2020. PMID: 32337408.
- Shi SX, Li TT, Wen XF, Wu S, Xiong CY, Zhao J, Lincha VR, Chow D S-L, Liu YY, Sood AK, Li C. Copper-64 labeled PEGylated exosomes for in vivo positron emission tomography and enhanced tumor retention. Bioconjugate Chemistry 30(10):2675-2683, 2019. e-Pub 2019. PMID: 31560538.
- Shi SX, Wen XF, Li TT, Wen XX, Cao QZ, Liu XL, Liu YY, Pagel MD, Li C. Thermosensitive biodegradable copper sulfide nanoparticles for real-time multispectral optoacoustic tomography. ACS Appl Bio Mater 2(8):3203-3211, 2019. PMID: 33907729.
- Xiong C, Yin D, Li J, Huang Q, Ravoori MK, Kundra V, Zhu H, Yang Z, Lu Y, Li C. Metformin reduces renal uptake of radiotracers and protects kidneys from radiation-induced damage. Mol Pharm 16(2):808-15, 2019. e-Pub 2019. PMID: 30608713.
- Zhao J, Wen XF, Tian L, Li TT, Xu CY, Wen XX, Melancon MP, Gupta S, Shen BZ, Peng WY, Li C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Commun 10(1):article number: 899 (p1-14), 2019. PMID: 30796212.
- Hsiao C-H, Zhao J, Gao S, Farhan N, Wang Y, Li C, Chow D S-L. Development and validation of a rapid and sensitive UPLC MS/MS assay for simultaneous quantification of paclitaxel and cyclopamine in mouse whole blood and tissue samples. Biomed Chromatogr 33(9):e4518, 2019. PMID: 30805953.
- Cao QZ, Huang Q, Mohan C, Li C. μPET/CT imaging of local and systemic immune response using 64Cu-αCD11b. J Nucl Med 60(9):1317-1324, 2019. e-Pub 2019. PMID: 30796172.
- Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin αγβ3-targeted [64Cu]CuS nanoparticles for PET/CT imaging and photothermal ablation therapy. Bioconjug Chem 29(12):4062–71, 2018. e-Pub 2018. PMID: 30404438.
- Ku G, Huang Q, Wen X, Ye J, Piwnica-Worms D, Li C. Spatial and temporal confined photothermolysis of cancer cells mediated by hollow gold nanospheres targeted to epidermal growth factor receptors. ACS Omega 3(5):5888-5895, 2018. PMID: 29876540.
- Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 159:215-228, 2018. e-Pub 2018. PMID: 29331808.
- Liu F, Liu T, Xu X, Guo X, Li N, Xiong C, Li C, Zhu H, Yang Z. Design, synthesis, and biological evaluation of 68Ga-DOTA-PA1 for lung cancer: A novel PET tracer for multiple somatostatin receptor imaging. Mol Pharm 15(2):619-628, 2018. e-Pub 2018. PMID: 29278911.
- Cao Q, Yan X, Chen K, Huang Q, Melancon MP, Lopez G, Cheng Z, Li C. Macrophages as a potential tumor-microenvironment target for noninvasive imaging of early response to anticancer therapy. Biomaterials 152:63-76, 2018. e-Pub 2017. PMID: 29111494.
- Xiong C, Lu W, Zhou M, Wen X, Li C. Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol 9(1):6 (1-13), 2018. e-Pub 2018. PMID: 30147806.
- Zhao Jun, Xiao ZL, Li TT, Chen HQ, Yuan Y, Wang YA, Hsiao CH, Chow DSL, Overwijk WW, Li C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 12(10):9881–9893, 2018. e-Pub 2018. PMID: 30231203.
- Chen G, Ma B, Wang Y, Xie R, Li C, Dou K, Gong S. CuS-based theranostic micelles for NIR-controlled combination chemotherapy and photothermal therapy, and photoacoustic imaging. ACS Appl Mater Interfaces 9(48):41700-41711, 2017. e-Pub 2017. PMID: 29154532.
- Li Y, Singh N, Yan J, Chen DH, Zhou M, Mittelstaedt RA, Chen Y, Li C, Doak SH, Chen T. Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials. Mutagenesis 32(1):151-59, 2017. e-Pub 2016. PMID: 27567283.
- Ma Q, Zhou D, DeLyria ES, Wen X, Lu W, Thapa P, Liu C, Li D, Bassett RL, Overwijk WW, Hwu P, Li C.. Synthetic poly(L-glutamic acid)-conjugated CpG exhibits antitumor efficacy with increased retention in tumor and draining lymph nodes after intratumoral injection in a mouse model of melanoma. J Immunother 40(1):11-20, 2017. e-Pub 2016. PMID: 27681378.
- Wang W, Zhao J, Wen X, Lin CC, Li J, Huang Q, Yu Y, Lin SY, Li C. MicroPET/CT imaging of AXL downregulation by HSP90 inhibition in triple-negative breast cancer. Contrast Media Mol Imaging 2017:1686525, 2017. e-Pub 2017. PMID: 29097911.
- Li J, Zhou M, Liu F, Xiong C, Wang W, Cao Q, Wen X, Robertson JD, Ji X, Wang YA, Gupta S, Li C.. Hepatocellular carcinoma: Intra-arterial delivery of doxorubicin-loaded hollow gold nanospheres for photothermal ablation-chemoembolization therapy in rats. Radiology 281(2):427-435, 2016. e-Pub 2016. PMID: 27347765.
- Belousova N, Mikheeva G, Xiong C-Y, Stagg LJ, Gagea M, Fox PS, Bassett R, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget 7(33):53414-53429, 2016. PMID: 27462785.
- Hatakeyama H, Wu SY, Lyons YA, Pradeep S, Wang W, Huang Q, Court KA, Liu T, Nie S, Rodriguez-Aguayo C, Shen F, Huang Y, Hisamatsu T, Mitamura T, Jennings N, Shim J, Dorniak PL, Mangala LS, Petrillo M, Petyuk VA, Schepmoes AA, Shukla AK, Torres-Lugo M, Lee JS, Rodland KD, Fagotti A, Lopez-Berestein G, Li C, Sood AK.. Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers. Cell Reports 17(6):1621-31, 2016. PMID: 27806300.
- Liu F, Zhu H, Lin XF, Xiong CY, Li C, Yang Z. Design and radio-synthesis of somatostatin receptors targeted 68Ga-DOTA-Benereotide for non-invasive PET imaging. J Radio Nucl Chem 307:1069-75, 2016.
- Li J, Liu F, Gupta S, Li C. Interventional nanotheranostics of pancreatic ductal adenocarcinoma. Theranostics 6(9):1393-402, 2016. PMID: 27375787.
- Tam AL, Melancon MP, Abdelsalam M, Figueira TA, Dixon K, McWatters A, Zhou M, Huang Q, Mawlawi O, Dunner K, Li C, Gupta S.. Imaging intratumoral nanoparticle uptake after combining nanoembolization with various ablative therapies in hepatic VX2 rabbit tumors. J Biomed Nanotech 12(2):296-307, 2016. PMID: 27305763.
- Zhou M, Melancon M, Stafford RJ, Li J, Nick AM, Tian M, Sood AK, Li C. Precision nanomedicine using dual positron emission tomography and magnetic resonance temperature imaging-guided photothermal therapy. J Nucl Med 57(11):1778-83, 2016. e-Pub 2016. PMID: 27283932.
- Liu Q, Zhou M, Li P, Ku G, Huang G, Li C, Song S. (64) CuS-labeled nanoparticles: a new sentinel-lymph-node-mapping agent for PET-CT and photoacoustic tomography. Contrast Media Mol Imaging 11(6):475-81, 2016. PMID: 27523742.
- Zhou M, Song, SL, Zhao J, Tian M, Li C. Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy (Cover Illustration). J Mater Chem B 3(46):8939-48, 2015. e-Pub 2015. PMID: 27725882.
- Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK. Erythropoietin stimulates tumor growth via EphB4. Cancer Cell 28(5):610-22, 2015. PMID: 26481148.
- Zhao J, Qiao Y, Zhou M, Wallace M, Gupta S, Li C*, Melancon MP*.. Antitumor efficacy study using irreversible electroporation and doxorubicin-loaded polymeric micelles. ACS Macro Lett 4(10):1081-84, 2015. PMID: 28529822.
- Zhou M, Chen Y, Adachi M, Wen X, Erwin B, Mawlawi O, Lai SY, Li C. Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer. Biomaterials 57:41-9, 2015. e-Pub 2015. PMID: 25913249.
- DeLyria ES, Zhou D, Lee JS, Singh S, Song W, Li F, Sun Q, Lu H, Wu J, Qiao Q, Hu Y, Zhang G, Li C, Sastry KJ, Shen H. Sublingual injection of microparticles containing glycolipid ligands for NKT cells and subunit vaccines induces antibody responses in oral cavity. Carbohydr Res 405:87-92, 2015. e-Pub 2014. PMID: 25555750.
- Zhao J, Wu C, Abbruzzese J, Hwang RF, Li C. Cyclopamine-loaded core-crosslinked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Mol Pharm 12(6):2093-100, 2015. e-Pub 2015. PMID: 25936695.
- You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. J Controlled Release 202:40-8, 2015. e-Pub 2015. PMID: 25637565.
- Zhou M, Li J, Liang S, Sood AK, Liang D, Li C. CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy. ACS Nano 9(7):7085-96, 2015. e-Pub 2015. PMID: 26098195.
- Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model (Cover Illustration). Nanoscale 7(46):19438-47, 2015. e-Pub 2015. PMID: 26376843.
- Zhou M, Ku G, Pageon L, Li C. Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. Nanoscale 6(24):15228-35, 2014. e-Pub 2014. PMID: 25379880.
- Hong Y, Zhu H, Hu J, Lin XF, Wang F, Li C, Yang Z. Synthesis and radiolabeling of 111In-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging. Bioorg Med Chem Lett 24(12):2781-5, 2014. PMID: 24815512.
- You J, Zhou J, Zhou M, Liu Y, Robertson JD, Liang D, Van Pelt C, Li C. Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres. Part Fibre Toxicol 11(26):1-17, 2014. PMID: 24886070.
- Melancon MP, Zhou M, Zhang R, Xiong C, Allen P, Wen X, Huang Q, Wallace M, Myers JN, Stafford RJ, Liang D, Ellington AD, Li C. Selective uptake and imaging of aptamer- and antibody-conjugated hollow nanospheres targeted to epidermal growth factor receptors overexpressed in head and neck cancer. ACS Nano 8(5):4530-8, 2014. PMID: 24754567.
- You J, Zhang P, Hu F, Du Y, Yuan H, Zhu J, Wang Z, Zhou J, Li C. Near-infrared light sensitive liposomes for the enhanced photothermal tumor treatment by the combination with chemotherapy. Pharm Res 31(3):554-65, 2014. e-Pub 2013. PMID: 24022681.
- Huang M, Xiong C, Lu W, Zhang R, Zhou M, Huang Q, Weinberg J, Li C. Dual-modality micro-positron emission tomography/computed tomography and near-infrared fluorescence imaging of EphB4 in orthotopic glioblastoma xenograft models. Mol Imaging Biol 16(1):74-84, 2014. e-Pub 2013. PMID: 23918654.
- Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Controlled Rel 172(1):152-8, 2013. PMID: 23920038.
- Tian M, Lu W, Zhang R, Xiong C, Ensor J, Nazario J, Jackson J, Shaw C, Dixon KA, Miller J, Wright K, Li C, Gupta S. Tumor uptake of hollow gold nanospheres after intravenous and transcatheter arterial injection: A PET/CT study in a rabbit VX2 liver cancer model. Mol Imaging Biol 15(5):614-24, 2013. e-Pub 2013. PMID: 23608932.
- Zhao N, You J, Zeng Z, Li C*, Zu Y*. An ultra pH-sensitive and aptamer-equipped nanoscale drug-delivery system for selective killing of tumor cells. Small 9(20):3477-84, 2013. e-Pub 2013. PMID: 23609964.
- You J, Wang ZH, Du YZ, Yuan H, Zhang PZ, Zhou JL, Liu F, Li C, Hu FQ. Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres. Biomaterials 34(18):4510-19, 2013. e-Pub 2013. PMID: 23510855.
- Zhang R, Huang M, Zhou M, Wen X, Huang Q, Li C. Annexin A5-functionalized nanoparticle for multimodal imaging of cell death. Mol Imaging 12(3):182-190, 2013. PMID: 23490444.
- Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging. Molecules 18(6):6425-38, 2013. PMID: 23722731.
- Song SL, Xiong CY, Lu W, Ku G, Huang G, Li C. Apoptosis imaging probe predicts early chemotherapy response in preclinical models: a comparative study with 18F-FDG PET. J Nucl Med 54(1):104-10, 2013. PMID: 23283564.
- Zhao J, Song S, Zhong M, Li C. Dual-modal tumor imaging via long-circulating biodegradable core-crosslinked polymeric micelles. ACS Macro Lett 1(1):150-153, 2012. e-Pub 2011. PMID: 22685693.
- You J, Zhang R, Zhang G-D, Zhong M, Liu Y, Van Pelt CS, Liang D, Wei W, Sood AK, Li C. Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. J Controlled Rel 158(2):319-328, 2012. e-Pub 2011. PMID: 22063003.
- Lu W, Xiong C, Zhang R, Shi L, Huang M, Zhang G, Song S, Huang Q, Liu GY, Li C. Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors (Cover Illustration). J Controlled Rel 161(3):959-966, 2012. e-Pub 2012. PMID: 22617522.
- Shen HF, You J, Zhang GD, Ziemys A, Li QP, Bai LT, Deng XY, Erm DR, Liu XW, Li C, Ferrari M. Cooperative, nanoparticle-enabled thermal therapy of breast cancer (Cover Illustration). Adv Healthcare Mat 1(1):84-89, 2012. e-Pub 2011. PMID: 23184690.
- Gupta S, Stafford RJ, Javedi S, Ozkan E, Ensor J, Wright K, Elliot A, Jian Y, Serda R, Wallace M, Li C. Effects of near-infrared laser irradiation of biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intra-arterially in a rabbit liver tumor model. J Vas Interv Radiol 23(4):553-561, 2012. PMID: 22341633.
- Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials 33(21):5376-5383, 2012. e-Pub 2012. PMID: 22541356.
- Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong CY, Hittelman WN, Wen XX, Marks JW, Cheung LH, Boland K, Adams GP, Li C, Rosenblum MG. Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Mol Cancer Ther 11(1):143-153, 2012. e-Pub 2011. PMID: 22090420.
- You J, Zhang R, Xiong C, Zhong M, Melancon M, Gupta S, Nick AM, Sood AK, Li C. Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors (Cover Illustration). Cancer Res 72(18):4777-86, 2012. PMID: 22865457.
- Ku G, Zhou M, Song S, Huang Q, Hazle J, Li C. Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. ACS Nano 6(8):7489-96, 2012. e-Pub 2012. PMID: 22812694.
- Yang Z, Xiong C, Zhang R, Zhu H, Li C. Synthesis and evaluation of (68)Ga-labeled DOTA-2-deoxy-D-glucosamine as a potential radiotracer in μPET imaging. Am J Nucl Med Mol Imaging 2(4):499-507, 2012. e-Pub 2012. PMID: 23145365.
- Zhang R, Xiong C, Huang M, Zhou M, Huang Q, Wen X, Liang D, Li C. Peptide-conjugated polymeric micellar nanoparticles for dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts. Biomaterials 32(25):5872-9, 2011. e-Pub 2011. PMID: 21612822.
- Xiong C, Brewer K, Song S, Zhang R, Lu W, Wen X, Li C. Peptide-based imaging agents targeting phosphatidylserine for the detection of apoptosis. J Med Chem 54(6):1825-35, 2011. PMID: 21348464.
- Xiong C, Huang M, Zhang R, Song S, Lu W, Flores L, Gelovani J, Li C. In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptide. J Nucl Med 52(2):241-8, 2011. PMID: 21233177.
- Wen X, Lyu MA, Zhang R, Lu W, Huang Q, Liang D, Rosenblum MG, Li C. Biodistribution, pharmacokinetics, and nuclear imaging studies of (111)In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma. Mol Imaging Biol 13(4):721-9, 2011. PMID: 20686856.
- Tian M, Wen X, Jackson EF, Ng C, Uthamanthil R, Liang D, Gelovani JG, Li C. Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study. Contrast Media Mol Imaging 6(4):289-97, 2011. PMID: 21861289.
- Melancon MP, Elliott A, Ji X, Shetty A, Yang Z, Tian M, Taylor B, Stafford RJ, Li C. Theranostics with multifunctional magnetic gold nanoshells: photothermal therapy and T2* magnetic resonance imaging. Invest Radiol 46(2):132-40, 2011. PMID: 21150791.
- Song S, Xiong C, Zhou M, Lu W, Huang Q, Ku G, Zhao J, Flores LG, Ni Y, Li C. Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-Bis-DOTA-hypericin. J Nucl Med 52(5):792-9, 2011. PMID: 21498539.
- Perin EC, Tian M, Marini III FC, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Shpall E, Gelovani JG. Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One 6(9):e22949, 2011. PMID: 21912635.
- Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release 156(2):265-272, 2011. e-Pub 2011. PMID: 21763373.
- Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multi-functional gold-based nanoshells for MR-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. PMID: 21745689.
- Zhang R, Lu W, Wen X, Huang M, Zhou M, Liang D, Li C. Annexin A5-conjugated polymeric micelles for dual SPECT and optical detection of apoptosis. J Nucl Med 52(6):958-64, 2011. e-Pub 2011. PMID: 21571801.
- Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. e-Pub 2011. PMID: 21745689.
- Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Song S, Zhang R, Flores LG, Gelovani JG, Wang LV, Ku G, Stafford RJ, Li C. Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res 71(19):6116-21, 2011. e-Pub 2011. PMID: 21856744.
- Lu W, Huang Q, Ku G, Wen X, Zhou M, Guzatov D, Brecht P, Su R, Oraevsky A, Wang LV, Li C. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials 31(9):2617-26, 2010. PMID: 20036000.
- Lu W, Zhang G, Zhang R, Flores LG, Huang Q, Gelovani JG, Li C. Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Res 70(8):3177-88, 2010. e-Pub 2010. PMID: 20388791.
- You J, Zhang G, Li C. Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release. ACS Nano 4(2):1033-41, 2010. PMID: 20121065.
- You J, Shao R, Wei X, Gupta S, Li C. Near-infrared light triggers release of Paclitaxel from biodegradable microspheres: photothermal effect and enhanced antitumor activity. SMALL 6(9):1022-31, 2010. PMID: 20394071.
- Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials 31(25):6567-73, 2010. PMID: 20537382.
- Belousova N, Mikheeva G, Xiong C, Soghomonian S, Young D, Le Roux L, Naff K, Bidaut L, Wei W, Li C, Gelovani J, Krasnykh V. Development of a targeted gene vector platform based on simian adenovirus serotype 24. J Virol 84(19):10087-101, 2010. PMID: 20631120.
- Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132(43):15351-8, 2010. PMID: 20942456.
- Li Y, Lu W, Huang Q, Huang M, Li C, Chen W. Copper sulfide nanoparticles for photothermal ablation of tumor cells. Nanomedicine (Lond) 5(8):1161-71, 2010. PMID: 21039194.
- Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behavior. Nanomedicine (London) 5(9):1357-69, 2010. PMID: 21128719.
- Xiong C, Lu W, Zhang R, Tian M, Tong W, Gelovani J, Li C. Cell-permeable [99mTc(CO3)]-labeled fluorogenic caspase 3 substrate for dual-modality detection of apoptosis. Chemistry 15(36):8979-84, 2009. PMID: 19637160.
- Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 206(7):1603-14, 2009. e-Pub 2009. PMID: 19564354.
- Thapa P, Zhang G, Xia C, Gelbard A, Overwijk WW, Liu C, Hwu P, Chang DZ, Courtney A, Sastry JK, Wang PG, Li C, Zhou D. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing energy. Vaccine 27(25-26):3484-8, 2009. PMID: 19200815.
- Zhang G, Yang Z, Lu W, Zhang R, Huang Q, Tian M, Li L, Liang D, Li C. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials 30(10):1928-36, 2009. PMID: 19131103.
- Yang Z, Kontoyiannis DP, Wen X, Xiong C, Zhang R, Albert ND, Li C. Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with a (111)In-labeled cyclic peptide. Nucl Med Biol 36(3):259-66, 2009. PMID: 19324271.
- Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, Lu W, Tian M, Gelovani JG, Qiao A, Li C. Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology 20(16):165101, 2009. e-Pub 2009. PMID: 19420561.
- Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C. Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres. Clin Cancer Res 15(3):876-86, 2009. PMID: 19188158.
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- Jackson EF, Esparza-Coss E, Wen X, Ng CS, Daniel SL, Price RE, Rivera B, Charnsangavej C, Gelovani JG, Li C. Magnetic resonance imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids. Int J Radiat Oncol Biol Phys 68(3):830-8, 2007. PMID: 17379450.
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- Liu Y, Zhang W, Cheung LH, Niu T, Wu Q, Li C, Van Pelt CS, Rosenblum MG. The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts. Neoplasia 8(5):384-93, 2006. PMID: 16790087.
- Li C, Wang W, Wu Q, Ke S, Houston J, Sevick-Muraca E, Dong L, Chow D, Charnsangavej C, Gelovani JG. Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe. Nucl Med Biol 33(3):349-58, 2006. PMID: 16631083.
- Oh SH, Lee OH, Schroeder CP, Oh YW, Ke S, Cha HJ, Park RW, Onn A, Herbst RS, Li C, Lee HY. Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition. Mol Cancer Ther 5(11):2685-95, 2006. PMID: 17121915.
- Wang W, McMurray JS, Wu Q, Campbell ML, Li C. Convenient solid-phase synthesis of diethylenetriaminepenta-acetic acid (DTPA)-conjugated cyclic RGD peptide analogues. Cancer Biother Radiopharm 20(5):547-56, 2005. PMID: 16248770.
- Houston JP, Ke S, Wang W, Li C, Sevick-Muraca EM.. Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe. J Biomed Opt 10(5):054010, 2005. PMID: 16292970.
- Hwang K, Houston JP, Rasmussen JC, Joshi A, Ke S, Li C, Sevick-Muraca EM. Improved excitation light rejection enhances small-animal fluorescent optical imaging. Mol Imaging 4(3):194-204, 2005. PMID: 16194451.
- Gurfinkel M, Ke S, Wang W, Li C, Sevick-Muraca EM.. Quantifying molecular specificity of avb3 integrin-targeted optical contrast agents with dynamic optical imaging. J Biomed Opt 10(3):034019, 2005. PMID: 16229663.
- Kwon S, Ke S, Houston JP, Wang W, Wu QP, Li C, Sevick-Muraca EM.. Dose-dependent uptakes of an RGD-fluorescent dye-targeted to avb3 receptor expressed in Kaposi’s sarcoma. Mol Imaging 4(2):75-87, 2005. PMID: 16105505.
- Wang W, Wu Q, Pasuelo M, McMurray JS, Li C. Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization. Bioconjug Chem 16(3):729-34, 2005. PMID: 15898744.
- Wen X, Jackson EF, Price RE, Kim EE, Wu Q, Wallace S, Charnsangavej C, Gelovani JG, Li C. Synthesis and characterization of poly(L-glutamic acid) gadolinium chelate: a new biodegradable MRI contrast agent. Bioconjug Chem 15(6):1408-15, 2004. PMID: 15546209.
- Wang W, Ke S, Wu Q, Charnsangavej C, Gurfinkel M, Gelovani JG, Abbruzzese JL, Sevick-Muraca EM, Li C. Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. Mol Imaging 3(4):343-51, 2004. PMID: 15802051.
- Ke S, Wen X, Wu QP, Wallace S, Charnsangavej C, Stachowiak AM, Stephens CL, Abbruzzese JL, Podoloff DA, Li C. Imaging taxane-induced tumor apoptosis using PEGylated, 111In-labeled annexin V. J Nucl Med 45(1):108-15, 2004. PMID: 14734682.
- Tansey W, Ke S, Cao XY, Pasuelo MJ, Wallace S, Li C. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J Control Release 94(1):39-51, 2004. PMID: 14684270.
- Ke S, Wen X, Gurfinkel M, Charnsangavej C, Wallace S, Sevick-Muraca EM, Li C. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res 63(22):7870-5, 2003. PMID: 14633715.
- Wen X, Wu QP, Ke S, Wallace S, Charnsangavej C, Huang P, Liang D, Chow D, Li C. Improved radiolabeling of PEGylated protein: PEGylated annexin V for noninvasive imaging of tumor apoptosis. Cancer Biother Radiopharm 18(5):819-27, 2003. PMID: 14629830.
- Vega J, Ke S, Fan Z, Wallace S, Charnsangavej C, Li C. Targeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(L-glutamic acid) through a polyethylene glycol spacer. Pharm Res 20(5):826-32, 2003. PMID: 12751641.
- Milas L, Mason KA, Hunter N, Li C, Wallace S. Poly(L-glutamic acid)-paclitaxel conjugate is a potent enhancer of tumor radiocurability. Int J Radiat Oncol Biol Phys 55(3):707-12, 2003. PMID: 12573758.
- Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC. Paclitaxel-induced inactivation of p70 S6 kinase is associated with phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 22(4):484-497, 2003. PMID: 12555062.
- Auzenne E, Donato NJ, Li C, Leroux E, Price RE, Farquhar D, Klostergaard J. Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian carcinoma. Clin Cancer Res 8(2):573-81, 2002. PMID: 11839679.
- Wen X-X, Wu Q-P, Ke S, Ellis L, Charnsangavej C, Delpassand AS, Wallace S, Li C. Conjugation with (111)In-DTPA-poly(ethylene glycol) improves imaging of anti-EGF receptor antibody C225. J Nucl Med 42(10):1530-37, 2001. PMID: 11585869.
- Wen X, Wu QP, Lu Y, Fan Z, Charnsangavej C, Wallace S, Chow D, Li C. Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains. Bioconjug Chem 12(4):545-53, 2001. PMID: 11459459.
- Ke S, Milas L, Charnsangavej C, Wallace S, Li C. Potentiation of radioresponse by polymer-drug conjugates. J Control Release 74(1-3):237-42, 2001. PMID: 11489500.
- Zou Y, Wu QP, Tansey W, Chow D, Hung MC, Charnsangavej C, Wallace S, Li C. Effectiveness of water-soluble poly(L-glutamic acid)-camptothecin conjugate against resistant human lung cancer xenografted in nude mice. Int J Oncol 18(2):331-6, 2001. PMID: 11172600.
- Li C, Newman RA, Wu QP, Ke S, Chen W, Hutto T, Kan Z, Brannan MD, Charnsangavej C, Wallace S. Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor. Cancer Chemother Pharmacol 46(5):416-22, 2000. PMID: 11127947.
- Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Potentiation of ovarian OCa-1 tumor radioresponse by poly (L-glutamic acid)-paclitaxel conjugate. Int J Radiat Oncol Biol Phys 48(4):1119-26, 2000. PMID: 11072171.
- Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin Cancer Res 6(7):2829-34, 2000. PMID: 10914731.
- Wallace S, Kan Z, Li C. Hepatic chemoembolization: clinical and experimental correlation. Acta Gastroenterol Belg 63(2):169-73, 2000.
- Oldham EA, Li C, Ke S, Wallace S, Huang P. Comparison of action of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in human breast cancer cells. Int J Oncol 16(1):125-32, 2000. PMID: 10601557.
- Inoue T, Li C, Yang DJ, Higuchi T, Oriuchi N, Yu D, Milas L, Hunter N, Wallace S, Kim EE, Podoloff DA. Evaluation of In-111 DTPA-paclitaxel scintigraphy to predict response on murine tumors to paclitaxel. Ann Nucl Med 13(3):169-74, 1999. PMID: 10435377.
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- Multani AS, Li C, Ozen M, Imam AS, Wallace S, Pathak S. Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity. Oncol Rep 6(1):39-44, 1999. PMID: 9864398.
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- Multani AS, Li C, Ozen M, Yadav M, Yu DF, Wallace S, Pathak S. Paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line. Anticancer Res 17(6D):4269-74, 1997. PMID: 9494519.
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Invited Articles
- Zhao J, Koay EJ, Li T, Wen X, Li C. A hindsight reflection on the clinical studies of poly(L-glutamic acid)-paclitaxel. Wiley Interdiscip Rev Nanomed Nanobiotechnol 10(3):e1497, 2018. e-Pub 2017. PMID: 28895304.
- Zhou M, Tian M, Li C. Copper-based nanomaterials for cancer imaging and therapy. Bioconjugate Chem 27(5):1188-99, 2016. e-Pub 2016. PMID: 27094828.
- Gharpure KM, Wu SY, Li C, Lopez-Berestein G, Sood AK. Nanotechnology: Future of oncotherapy. Clin Cancer Res 21(14):3121-30, 2015. PMID: 26180057.
- Li C. A targeted approach to cancer imaging and therapy. Nat Mater 13(2):110-5, 2014. PMID: 24452345.
- Li J, Gupta S, Li C. Research perspectives: gold nanoparticles in cancer theranostics. Quant Imaging Med Surg 3(6):284-91, 2013. PMID: 24404441.
- Li C. Image-guided photonic energy deposition for cancer ablation and drug delivery. Curr Med Imaging Rev 8:267-277, 2012.
- Melancon MP, Stafford RJ, Li C. Challenges to effective cancer nanotheranostics. J Control Release 164(2):177-82, 2012. PMID: 22906841.
- Melancon MP, Li C. Multifunctional synthetic poly(L-glutamic acid)-based cancer therapeutic and imaging agents. Mol Imaging 10(1):28-42, 2011. PMID: 21303613.
- Melancon MP, Zhou M, Li C. Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Acc Chem Res 44(10):947-956, 2011. e-Pub 2011. PMID: 21848277.
- Melancon M, Lu W, Li C. Gold-based magneto/optical nanostructures: Challenges for in vivo applications in cancer diagnostics and therapy. Mater Res Bull 34:415-421, 2009.
- Li C, Wallace S. Polymer-drug conjugates: Recent development in clinical oncology. Adv Drug Deliv Rev 60:886-98, 2008.
- Belhocine T, Steinmetz N, Li C, Green A, Blankenberg FG. The imaging of apoptosis with radiolabeled Annexin V: Optimal timing for clinical feasibility. Tech Cancer Res Treat 3:23-32, 2004.
- Belhocine TZ, Tait JF, Vanderheyden J-L, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V (Perspectives). J Proteome Res 3:345-349, 2004.
- Wen XX, Cao XY, Pasuelo MJ, Wendt R, Li C. Polymeric radiotracers in nuclear imaging. Curr Drug Deliv 1:377-384, 2004.
- Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM. Near-infrared fluorescence optical imaging and tomography. Dis Markers 19(2-3):107-121, 2003. PMID: 15096708.
- Li C. Poly(L-glutamic acid)-anticancer drug conjugates. Adv Drug Deliv Rev 54:695-713, 2002.
- Li C, Newman R, Wallace S. Reformulating paclitaxel. Science & Medicine 6:38-47, 1999.
Abstracts
- Cao Q, Li C. µPET imaging of tumor-bearing mice using 64Cu-labeled anti-CD11b antibody. CSI Spring Retreat, 2022.
- Wen X-X, Li C. Concurrent injection of cold antibody allows PET imaging of orthotopic pancreatic tumor with 64Cu-labeled anti-PD-L1. SNMMI Annual Meeting, Anaheim, CA, 2019.
- Cao QZ, Wen XX, Du Y, Mohan C, Li C. μPET/CT imaging of experimental autoimmune nephritis using 64Cu-antiCD11b. SNMMI Annual Meeting, Anaheim, CA, 2019.
- Xiong CY, Du Y, Cao QZ, Alpay M, Mohan C, Li C. Two stage µPET/CT imaging of TCO-anti-CD11b with a 64Cu-NOTA-tetrazine tracer to monitor anti-GBM and lupus nephritis. SNMMI Annual Meeting, Anaheim, CA, 2019.
- Shi SX, Li TT, Cao QZ, Sood A, Li C. Radiolabeled exosomes for in vivo assessment of cancer homing potential. SNMMI Annual Meeting, Anaheim, CA, 2019.
- Shi SX, Li TT, Wen XF, Wen XX, Pagel MD, Li C. Anti-folate receptor 1 antibody-conjugated copper sulfide nanoparticles for in vivo multispectral optoacoustic tomography. SNMMI Annual Meeting, Anaheim, CA, 2019.
- Zhao J, Wen XF, Li TT, Melancon MP, Gupta S, Peng WY, Li C. Irreversible electroporation induces immunogenic cell death and mediates durable response in orthotopic PDAC model in combination with anti-PD-1. AACR Annual Meeting, Atlanta, GA, 2019.
- Zhao J, Xiao Z, Overwijk W, Li C. Pharmacological Modulation of Pancreatic Tumor - associated Stroma to Enhance Checkpoint Blockade Immunotherapy. 2018 AACR Annual Meeting, Chicago, IL, 2018.
- Shi SX, Wen XX, Li TT, Li C. Thermosensitive biodegradable Copper Sulfide Nanoparticles for in vivo Multispectral Optoacoustic Tomography. 2018 SNMMI Annual Meeting, Philadelphia, PA, 2018.
- Cao Q, Huang Q, Li C. microPET/CT imaging of sentinel lymph nodes with tumor metastasis in B16Ova (Luc/GFP) melanoma bearing mice using 64 Cu-αCD11b. 2018 SNMMI Annual Meeting, Philadelphia, PA, 2018.
- Zhao J, Wang H, Hsiao C-H, Chow D, Kang Y, Maitra A, Piwnica-Worms D, Fleming J, Li C. Simultaneous targeting stroma and tumor cell compartments alleviates hypoxia, reduces inflammatory response, and enhances anti-PDAC therapy in KPC mice. 2017 Keystone Symposium on Cancer Immunology and Immunotherapy, Whistler, British Columbia, Canada, 2017.
- Wang W, Wen X, Zhao J, Lin CJ, Huang Q, Lin SY, Li C. Micro-PET/CT imaging of Axl expression in breast cancer xenografts and their response to 17-allylamino-17-demethoxygeldanamycin (17-AAG) treatment. 2016 SNMMI Annual Meeting, San Diego, CA, 2016.
- Zhao J, Li J, Wang W, Huang Q, Wen X, Li C.. Pancreatic Cancer Therapy using Polyion Complex Micelles Loaded with Cyclopamine and Paclitaxel. 2016 11th International Symposium on Polymer Therapeutics, Valencia, Spain, 2016.
- Zhao J, Wu C, Wen X, Huang Q, Li C.. Pancreatic cancer therapy using polyion micelles co-loaded with cyclopamine and paclitaxel. 2016 AACR Annual Meeting, New Orleans, LA, 2016.
- Li J, Zhou M, Xiong C, Wang W, Cao Q, Wen X, Ji X, Wang YA, Gupta S, Li C. Intraarterial Delivery of Doxorubicin-Loaded Hollow Gold Nanospheres for Photothermal Ablation–Chemotherapy of Hepatocellular Carcinoma in the Liver of Rats. 2016 AACR Annual Meeting, New Orleans, LA, 2016.
- Cao Q, Huang Q, Li C. microPET/CT imaging of the mobilization of CD11b+ cells. 2016 AACR Annual Meeting, New Orleans, LA, 2016.
Book Chapters
- Zhou M, Li L, Yao J, Bouchard RR, Wang LV, Li C.. Nanoparticles for Photoacoustic Imaging of Vasculature. In: Design and Applications of Nanoparticles in Biomedical Imaging. 1. Springer International Publishing: Switzerland, 337-356, 2017.
- Lu W, Melancon MP, Li C. Theranostic applications of gold core-shell structured nanoparticles. In: Theranostic Nanoplatform-Based Molecular Imaging. John Wiley & Sons, Inc: Hoboken, NJ, 2012.
- Li C, Zhang JZ. Hollow gold nanospheres (HAuNS). In: Encyclopedia of Nanotechnology. Springer Verlag GmbH: Heidelberg, Germany, 2012.
- Melancon MP, Wen X-X, Zhang G-D, Li C. Multi-functional, multi-modality cancer imaging with water- soluble synthetic polymers. In: Nanoimaging. Pan Stanford Publishing Pte Ltd: Singapore, 171-195, 2011.
- Melancon MP, Li C. Core-shell magnetic nanomaterials in medical diagnosis and therapy. In: Magnetic Nanomaterials. Wiley-VCH Verlag GmbH & Co: Weinheim, Germany, 259-290, 2009.
- Zhang G-D, Jackson E, Wallace S, Li C. Poly (L-glutamic acid): efficient carrier of cancer therapeutics and diagnostics. In: Nanotechnology for Cancer Therapeutics: Boca Raton, FL, 185-199, 2007.
- Yang DJ, Li C, Kim EE. Imaging of anticancer drugs, response and prognosis. In: Targeted Imaging in Oncology. Springer-Verlag: New York, 185-200, 2001.
- Li C, Jackson E. Polymer-based compounds for targeted imaging. In: Targeted Imaging in Oncology. Springer-Verlag: New York, 111-121, 2001.
- Singer J, De Vries P, Bhatt R, Tulinsky J, Klein P, Li C, Milas L, Lewis RA, Wallace S. Conjugation of camptothecins to poly(L-glutamic acid). In: The Camptothecins: Unfolding Their Anticancer Potential. The New York Academy of Sciences: New York, 136-150, 2000.
- Yang DJ, Gretzer MB, Kuang L-R, Cherif A, Li C, Diaz MF, Liu C-W, Emran A, Tansey W, Wallace S. Radiolabeled tamoxifen analogues for imaging breast cancer with SPECT. In: Chemists' View of Imaging Center. Plenum Publishing Corporation: New York, 513-526, 1995.
- Yang DJ, Wallace S, Kuang L-R, Li C, Cherif A, Kan Z-X, McCuskey P, Wright KC. Microencapsulation, tamoxifen analogues and in vivo microscopy for tumor targeting. In: Cancer Treatment, An Update. Springer-Verlag: Paris, 817-819, 1994.
- Yang DJ, Kuang L-R, Li C, Liu C-W, Tsai T, Lin WJ, Tansey W, Nikiforow S, McCuskey P, Kan Z-X, Wright KC, Wallace S. Evaluation of poly(dl-lactide) encapsulated radiopaque microspheres. In: Polymeric Delivery System. American Chemistry Society: Washington DC, 372-382, 1992.
Books (edited and written)
- Li C, Tian M. Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action. Ed(s) Li C, Tian M. John Wiley & Sons: Hoboken, NJ, 2014.
- Li C, Currell FJ. Nanomaterials to Enhance the Effect of Ionizing Radiation. In: Special Issue of Cancer Nanotechnology. Ed(s) Li C, Currell FJ. Springer.
Grant & Contract Support
| Title: | Therapeutics and Novel Imaging Techniques |
| Funding Source: | John S Dunn Foundation Chemistry Laboratory for Imaging |
| Role: | Principal Investigator |
| Title: | Near-Infrared Fluorescence Nanoparticles for Targeted Optical Imaging |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Near-Infrared Semiconductor Nanocrystal for Imaging Guided Surgery |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Title: | Targeted Delivery of Cyclopamine by Biodegradable Core-Crosslinked Polymeric Micelles for Radio-Chemotherapy of Pancreatic Cancer |
| Funding Source: | Skip Viragh Foundation |
| Role: | Principal Investigator |
| Title: | The Medical Nanovector Research and Development Center of the Alliance for NanoHealth |
| Funding Source: | DOD/TARTRC |
| Role: | Principal Investigator |
| Title: | Subcellular Localization of Nanoparticles |
| Funding Source: | NIH/NIGMS |
| Role: | Principal Investigator-MDACC |
| Title: | Simultaneous Photothermal Ablation RNAi Therapy of Melanoma (Melanoma SPORE) |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Chemopreventive Effect of Fish Oil Derived EPA in Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | Multifunctional Hollow Gold Nanospheres for Concurrent Photothermal - Chemotherapy |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Title: | Selective Photothermal Ablation of HCC with Renal Clearable [64Cu]CuS Nanodots, General Electric-Center for Advanced Biomedical Imaging (CABI) |
| Funding Source: | General Electric-Center for Advanced Biomedical Imaging (CABI) - MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| Title: | Overcome Resistance to Immune Checkpoint Blockade in Pancreatic Ductal Adenocarcinoma by Enhancing Antigen Presentation |
| Funding Source: | Emerson Collective Cancer Research Fund |
| Role: | Principal Investigator |
| Title: | Induction of Tumor Immunity by Combining Nanoparticle-Based Photothermolysis with Checkpoint Inhibition for Ovarian Cancer |
| Funding Source: | Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | Development of Polymeric Micelles for Multimodality Treatment of Pancreatic Cancer |
| Funding Source: | University of Houston/Gillson Longenbaugh Foundation |
| Role: | Principal Investigator-MDACC |
| Title: | Novel Regulation and Function of TAK1 in Mutant Kras-driven Development of Pancreatic Ductal Adenocarcinoma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Title: | Chemoprevention of Hepatocellular Carcinoma by Disrupting Crosstalk Between c-Myc-expressing Hepatocytes and Hepatic Stellate Cells |
| Funding Source: | Duncan Family Institute Seed-funding, MD Anderson |
| Role: | Principal Investigator |
| Title: | 99mTc/Re Biguanide Complexes Targeting Mitochondria for Pancreatic Cancer Theranostics |
| Funding Source: | The University of Texas MD Anderson Cancer Center/CABI |
| Role: | Principal Investigator |
| Title: | Enhancing Antitumor Immunity with Nanoparticle-Mediated Photothermolysis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Imaging Markers for Early Diagnosis of Non-Small Cell Lung Cancer (NSCLC) |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Enhancing Antitumor Immunity with Nanoparticle-mediated Photothermolysis against Hepatocellular Carcinoma |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Title: | Development of Irreversible Electroporation-based Rational Combinations to Potentiate the Activity of Cancer Immunotherapy against Pancreatic Ductal Adenocarcinoma |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Assessing Imaging Biomarkers for Response to Combined IRE and Anti-PD-1 Immunotherapy |
| Funding Source: | MD Anderson Cancer Center QIAC (Partnership in Research Grants Program) |
| Role: | Co-Principal Investigator |
| Title: | Identification and Validation of Earliest Markers for Non-Small Cell Lung Cancer (NSCLC) |
| Funding Source: | University of Houston / CPRIT |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified June 11, 2024