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Cielito C. Reyes-Gibby, Dr. PH

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Associate Professor, Division of Management and Policy Sciences and Community Health, The University of Texas School of Public Health, Houston, TX

Bio Statement

Dr. Reyes-Gibby is an Associate Professor in the Department of Emergency Medicine in the Division of Internal Medicine and an Adjunct Associate Professor at The University of Texas School of Public Health. 

Dr. Reyes-Gibby is a population-based scientist with a focus on the application of epidemiological approaches and health survey research methodologies to the study of pain and cancer-related symptoms. Her first studies explored the under-recognition and under treatment of pain in the elderly and demonstrated racial and ethnic disparities in pain, depression, and fatigue in population-based samples of adults. Underpinning her academic growth is her ability to enhance her research by applying discoveries across disciplines. She is the first in the field to apply molecular epidemiology approaches to understand the complex interactions between socio-psychological factors and genetic variations on cancer-related symptoms. Notably, Dr. Reyes-Gibby has brought attention to the importance of the epidemiology of cancer-related symptoms, not just at the end-of-life but throughout cancer progression. 

She serves as Founding Chair of the Genetics and Pain Special Interest Group of the American Pain Society and is an invited member of the International Task Force for the Global Year Against Cancer Pain, an initiative of the International Association for the Study of Pain. More recently, she was invited to serve as a panelist for a National Institutes of Health initiative for identifying innovative and ground breaking scientific approaches to the study of the genetics of chronic pain conditions.

Research Interests

Pain and Cancer-Related Symptoms

Molecular Epidemiology

Neuropathic Pain

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler Blvd.
Unit Number: 1468
Houston, TX 77030
Room Number: FCT 13.5041
Phone: (713) 792-1816
Fax: (713) 745-1165

Education & Training

Degree-Granting Education

1998 The University of Texas School of Public Health, Houston, TX, DPH, Public Health

Postgraduate Training

6/2012-12/2012 Continuing Education, Statistical Modeling of the Genetics of Addiction, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
6/2008-7/2008 Continuing Education, Statistical Analyses for Genetic Epidemiology, Case Western Reserve University, Cleveland, OH
8/2007 Continuing Education, SNP Analyses Workshop, National Institute of Environmental and Health Sciences, Houston, TX
6/2006-8/2006 Continuing Education, Longitudinal Modeling, University of Texas School of Public Health, Houston, TX
1/2006-5/2006 Continuing Education, Molecular Epidemiology, University of Texas School of Biological Sciences, Houston, TX
6/2005-8/2005 Fellow, Molecular Genetics in Research, Health and Society, National Institutes of Health and Georgetown University, Bethesda, MD
7/2004 Continuing Education, Analyses of Longitudinal Data from Epidemiologic Studies, University of Michigan School of Public Health, Ann Arbor, MI
7/2004 Continuing Education, Genetics in Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI
6/2004 Continuing Education, Genetic Epidemiology in Populations, Johns Hopkins University, Baltimore, MD
6/2004 Continuing Education, Molecular Biology for Genetic Epidemiology, Johns Hopkins University, Baltimore, MD
1/1999-6/1999 Postdoctoral Trainee, Department of Health Services Organization, The University of Texas Graduate School of Public Health, Houston, TX, Dr. LuAnn Aday

Experience/Service

Academic Appointments

Associate Professor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-9/2012

Honors and Awards

2005 Fellowship, Summer Genetics Institute, National Institute of Health Research
2004-2009 Career Development Award, National Cancer Institute

Selected Publications

Peer-Reviewed Original Research Articles

1. Liao Z, Hao J, Guo Y, Reyes-Gibby CC, Bruera E, Guo H. Assessment of Cancer Pain Management knowledge in southwest China: A survey of 70 physicians in small city and county hospitals. Journal of Palliative Medicine. In Press.
2. Reyes-Gibby CC, Sy Ortin TT, Anderson KO, Gonzalez-Suarez CB, Shete S, Felly TW, Que JC. Depressive symptoms: Prevalence, factors and influence on health-related quality of life in Filipino cancer patients. In Press.
3. Reyes-Gibby CC, Wang J, Wu X, Shete S. Genetic variations in Interleukin 8 and Interluekin 10 are associated with pain, depressed mood and fatigue in lung cancer patients. In Press.
4. Dalal S, Hui D, Bidaul L, Lem K, Del Fabbro, Crane C, Reyes-Gibby CC, Bedi D, Bruera E. Relationship between body mass index, longitudinal body-composition alterations and survival in locally advanced pancreatic cancer patients receiving chemoradiation. A pilot study. J Pain Symptom Manage. In Press.
5. Reyes-Gibby CC, Swartz MD, Yu X, Spitz MR, Anderson KO, Wu X, Shete S. Symptom Clusters of Pain, Depressed Mood, and Fatigue in Lung Cancer: Assessing the Role of Cytokine Genes. Supportive Care in Cancer, 7/2013.
6. Yi JK, Anderson KO, Le YC, Escobar-Chaves SL, Reyes-Gibby CC. English Proficiency, Knowledge and Receipt of HPV Vaccine in Vietnamese-American Women. J Community Health. e-Pub 3/2013. PMID: 23526096.
7. Reyes-Gibby CC, Anderson KO, Morrow PK, Shete S, Hassan S. Depressive symptoms and health-related quality of life in breast cancer survivors. J Womens Health (Larchmt) 21(3):311-8, 3/2012. e-Pub 11/2011. PMCID: PMC3326444.
8. Reyes-Gibby CC, Anderson KO, Shete S, Bruera E, Yennurajalingam S. Early Referral to Supportive Care Specialists for Symptom Burden in Lung Cancer Patients: A Comparison of Non-Hispanic Whites, Hispanics, and Non-Hispanic Blacks. Cancer 118(3):856-63, 2/2012. e-Pub 7/2011. PMCID: PMC3193905.
9. Chen X, Gorlov IP, Ying J, Merriman KW, Kimmel M, Lu C, Reyes-Gibby CC, Gorlova OY. Initial medical attention on patients with early-stage non-small cell lung cancer. PLoS One 7(3):e32644, 2012. e-Pub 3/2012. PMCID: PMC3296738.
10. Yi JK, Swartz MD, Reyes-Gibby CC. English Proficiency, Symptoms, and Quality of Life in Vietnamese- and Chinese-American Breast Cancer Survivors. J Pain Symptom Manage 42(1):83-92, 7/2011. e-Pub 1/2011. PMID: 21227634.
11. Swartz MD, Peng B, Reyes-Gibby C, Shete S. Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. Stat Interface 4(3):285-94, 2011. PMCID: PMC3316326.
12. Yennurajalingam S, Urbauer DL, Casper KL, Reyes-Gibby CC, Chacko R, Poulter V, Bruera E. Impact of a Palliative Care Consultation Team on Cancer-Related Symptoms in Advanced Cancer Patients Referred to an Outpatient Supportive Care Clinic. J Pain Symptom Manage. e-Pub 8/2010. PMID: 20739141.
13. Reyes-Gibby C, Morrow PK, Bennett MI, Jensen MP, Shete S. Neuropathic pain in breast cancer survivors: Using the ID Pain as a screening tool. J Pain Symptom Manage 39(5):882-9, 5/2010. PMCID: PMC2872632.
14. Reyes-Gibby CC, Morrow PK, Buzdar A, Shete S. Chemotherapy-Induced Peripheral Neuropathy as a Predictor of Neuropathic Pain in Breast Cancer Patients Previously Treated with Paclitaxel. J Pain 10(11):1146-50, 11/2009. e-Pub 7/2009. PMCID: PMC2783933.
15. Reyes-Gibby CC, Spitz MR, Yennurajalingam S, Swartz M, Gu J, Wu X, Bruera E, Shete S. Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiol Biomarkers Prev 18(10):2636-42, 10/2009. e-Pub 9/2009. PMCID: PMC2759856.
16. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR. Genetic and non-genetic covariates of pain severity in patients with adenocarcinoma of the pancreas: Assessing the influence of cytokine genes. J Pain Symptom Manage 38(6):894-902, 8/2009. e-Pub 8/2009. PMCID: PMC2795073.
17. Reyes-Gibby CC, El Osta B, Spitz MR, Parsons H, Kurzrock R, Wu X, Shete S, Bruera E. The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care. Cancer Epidemiol Biomarkers Prev 17(11):3262-7, 11/2008. PMID: 18990769.
18. Torres-Vigil I, Aday LA, Reyes-Gibby CC, De Lima L, Herrera AP, Mendoza T, Cleeland CS. Health care providers' assessments of the quality of advanced-cancer care in Latin American medical institutions: a comparison of predictors in five countries: Argentina, Brazil, Cuba, Mexico, and Peru. J Pain Palliat Care Pharmacother 22(1):7-20, 2008. PMID: 19042817.
19. Reyes-Gibby CC, Spitz M, Wu X, Merriman K, Etzel C, Bruera E, Kurzrock R, Shete S. Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A. Cancer Epidemiol Biomarkers Prev 16(12):2745-51, 12/2007. PMID: 18086782.
20. Reddy S, Bruera E, Pace E, Zhang K, Reyes-Gibby CC. Clinically important improvement in the intensity of fatigue in patients with advanced cancer. J Palliat Med 10(5):1068-75, 10/2007. PMID: 17985963.
21. Reyes-Gibby CC, Chan W, Abbruzzese JL, Xiong HQ, Ho L, Evans DB, Varadhachary G, Bhat S, Wolff RA, Crane C. Patterns of Self-reported Symptoms in Pancreatic Cancer Patients Receiving Chemoradiation. J Pain Symptom Manage 34(3):244-252, 9/2007. e-Pub 5/2007. PMCID: PMC2084477.
22. Reyes-Gibby CC, Shete S, Rakvåg T, Bhat SV, Skorpen F, Bruera E, Kaasa S, Klepstad P. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 130(1-2):25-30, 7/2007. e-Pub 12/2006. PMCID: PMC1995596.
23. Reyes-Gibby CC, Aday LA, Todd KH, Cleeland CS, Anderson KO. Pain in aging community-dwelling adults in the United States: non-Hispanic whites, non-Hispanic blacks, and Hispanics. J Pain 8(1)(1):75-84, 1/2007. e-Pub 9/2006. PMCID: PMC1974880.
24. Reyes-Gibby CC, Aday LA, Anderson KO, Mendoza TR, Cleeland CS. Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer. J Pain Symptom Manage 32(2)(2):118-128, 8/2006. PMCID: PMC1950719.
25. Reyes-Gibby CC, Ba Duc N, Phi Yen N, Hoai Nga N, Van Tran T, Guo H, Bhat S, Cleeland C. Status of cancer pain in Hanoi, Vietnam: A hospital-wide survey in a tertiary cancer treatment center. J Pain Symptom Manage 31(5)(5):431-439, 5/2006. PMID: 16716873.
26. Cleeland C, Griesing T, Backonja M, Moskowitz R, Frey WD, Mekhail NA, Millea PJ, Nicholson BD, Reyes-Gibby, CC, Staats PS, Stockbridge H, Sunshine A, Brandenburg N, Goudie AR, Irish W, McLeod L, Whalen E. Development and testing of a neuropathic pain screening questionnaire: ID Pain. Curr Med Res Opin 22:1555-1565, 2006.
27. Reyes-Gibby CC, Aday LA. Access to health care in a rural area of the Philippines. Ethn Dis 15(1)(1):104-109, 2005. PMID: 15720056.
28. Weinstein SM, Romanus D, Lepisto EM, Reyes-Gibby CC, Cleeland C, Greene R, Muir C, Niland J. Documentation of pain in comprehensive cancer centers in the United States: A preliminary analysis. J Natl Compr Canc Netw 2(2)(2):173-180, 3/2004. PMID: 19777706.
29. Wang XS, Di LJ, Reyes-Gibby CC, Guo H, Liu SJ, Cleeland CS. End-of-life care in urban areas of China: a survey of sixty oncology clinicians. J Pain Symptom Manage 27(2)(2):125-130, 2/2004. PMID: 15157036.
30. Yi J, Reyes-Gibby CC. Breast cancer screening practices among low-income Vietnamese women. International Quarterly of Community Health Education 21(1):41-49, 9/2003.
31. Reyes-Gibby CC, Mendoza TR, Wang S, Anderson KO, Cleeland CS. Pain and fatigue in community-dwelling adults. Pain Med 4(3)(3):231-237, 9/2003. PMID: 12974822.
32. Cleeland CS, Reyes-Gibby CC, Schall M, Nolan K, Paice J, Rosenberg JM, Tollett JH, Kerns RD. Rapid improvement in pain management: the Veterans Health Administration and the Institute for Healthcare Improvement Collaborative. Clin J Pain 19(5)(5):298-305, Sep-Oct, 9/2003. PMID: 12966255.
33. Reyes-Gibby CC, McCrory LL, Cleeland CS. Variations in patients' self-report of pain by treatment setting. J Pain Symptom Manage 25(5)(5):444-448, 5/2003. PMID: 12727042.
34. Anderson KO, Getto CJ, Mendoza TR, Palmer SN, Wang XS, Reyes-Gibby CC, Cleeland CS. Fatigue and sleep disturbance in patients with cancer, patients with clinical depression, and community-dwelling adults. J Pain Symptom Manage 25(5)(4):307-318, 4/2003. PMID: 12691682.
35. Reyes-Gibby CC, Aday L, Cleeland C. Impact of pain on self-rated health in the community-dwelling older adults. Pain 95(1-2)(1-2):75-82, 1/2002. PMID: 11790469.
36. Reyes-Gibby CC, Aday LA. Prevalence of and risk factors for hypertension in a rural area of the Philippines. J Community Health 25(5)(5):389-399, 10/2000. PMID: 10982012.

Invited Articles

1. Anderson KO, Reyes-Gibby CC. Biopsychosocial Approach to Persistent Post-Mastectomy Pain: What Can We Conclude? Pain 154(5):623-4, 5/2013. e-Pub 3/2013. PMID: 23522928.
2. Reyes-Gibby CC, Wu X, Spitz M, Kurzrock R, Fisch M, Bruera E, Shete S. Molecular epidemiology, cancer-related symptoms, and cytokines pathway. Lancet Oncol 9(8):777-85, 8/2008. PMID: 18672213.

Editorials

1. Cleeland CS, Reyes-Gibby CC. Cancer-related Fatigue. Breast Diseases Quarterly 12(3):259-260, 10/2001.

Book Chapters

1. Reyes-Gibby C and Palos GR. Pain, aging, and ethnicity. In: Culture, genes, and analgesia: Understanding and managing pain in diverse populations. Ed(s) M Incayawar, K Todd. Oxford University Press: New York, New York. In Press.
2. Reyes-Gibby CC, Anderson KO. Cancer Pain, Epidemiology. In: Encyclopedia of Pain. Ed(s) Schmidt RF, Gebhart GF. Springer-Verlag Berlin Heidelberg, 2013.
3. Reyes-Gibby CC, Anderson KO. Cancer Pain Management, Patient-Related Barriers. In: Encyclopedia of Pain. Ed(s) Schmidt RF, Gebhart GF. Springer-Verlag Berlin Heidelberg, 2013.
4. Reyes-Gibby CC, Torres-Vigil I, Croock R. Epidemiology of Pain: Classical and Molecular Approaches. In: Clinical Pain Management 2E: Chronic volume, 2008.
5. Reyes-Gibby CC. Cancer pain management: patient-related barriers. In: Encyclopedic Reference on Pain. Ed(s) Schmidt RF, Willis WD. Springer Verlag: New York, NY, USA, 2007.
6. Reyes-Gibby CC, Cleeland CS. Pain Epidemiology. In: Encyclopedic Reference on Pain. Ed(s) Schmidt RF, Willis WD. Springer Verlag: Berlin, 2007.
7. Reyes-Gibby CC, Cleeland CS. Epidemiology of pain and cancer-related symptoms. In: Acute Care of the Cancer Patient. Ed(s) Shaw AD. Marcel Dekker, Inc., 1031-1039, 2006.
8. Aday LA, Quill BE, Reyes-Gibby CC. Equity in Rural Health and Health Care. In: Handbook of Rural Health. Plenum: New York, 45-72, 2001.

Letters to the Editor

1. Reyes-Gibby CC, Todd KH. Oligo-Evidence for Oligoanalgesia: A Non-Sequitur? Ann Emerg Med XX(X):373-4, 3/2013. PMID: 23433025.

Manuals, Teaching Aids, Other Teaching Publications

1. Reyes-Gibby CC. Breakthroughs and Challenges in the Management of Common Chronic Pain Conditions. Department of Health and Human Services Office of Women's Health, 2005.

Grant & Contract Support

Title: The Emergency Department Pain Registry: Impact Evaluation of the 2012 American College of Emergency Physicians Opioid Prescribing Guidelines
Funding Source: Pfizer
Role: Co-Principal Investigator
Principal Investigator: KH Todd
Duration: 12/1/2012 - 12/1/2014
 
Title: Molecular Epidemiology of Neuropathic Pain in Head and Neck Cancer
Funding Source: NIH/NIDCR
Role: Principal Investigator
Duration: 7/26/2012 - 6/30/2017
 
Title: Risk of opioid misuse and the management of chronic cancer pain in the Emergency Department
Funding Source: Emergency Medicine Foundation and the Emergency Medicine Patient Safety Foundation
Role: Co-Investigator
Principal Investigator: KH Todd
Duration: 7/1/2012 - 6/30/2013
 
Title: High Density Association Analysis for Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: C Amos
Duration: 6/2012 - 5/2013
 
Title: Consulting Agreement with St. Jude Children's Research Hospital
Funding Source: St. Jude Children's Research Hospital
Role: Consultant
Principal Investigator: Belinda Mandrell
Duration: 8/1/2011 - 7/31/2013
 
Title: Cytokine Polymorphisms and Symptoms
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/2008 - 8/2010
 
Title: Neuropathic Pain in Breast Cancer Survivors
Funding Source: Pfizer Inc.
Role: Principal Investigator
Duration: 12/1/2006 - 12/1/2009
 
Title: Gene Polymorphisms and Symptoms in Lung Cancer Patients
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2004 - 8/1/2009
 
Title: Needs Assessment for Cancer Pain Relief Programs in Three Cancer Centers in Vietnam
Funding Source: US Cancer Pain Relief Committee
Role: Principal Investigator
Duration: 1/1/2003
 
Title: National Survey of Pain in the US
Funding Source: American Pain Foundation
Role: Co-Investigator
Duration: 1/1/2002
 
Title: Multi-Center Pilot Evaluation of Pain Management and Outcomes within the National Comprehensive Cancer Network (NCCN),
Funding Source: National Comprehensive Cancer Network (NCCN)
Role: Principal Investigator
Duration: 1/1/2001 - 1/1/2003

Last updated: 7/25/2013