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Clifton David Fuller, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Director of MR Programmatic Development, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX
Cross-Appointed Research Instructor, Oregon Health and Science University, Portland, OR

Bio Statement

My research focus remains development of evidence-based"personalized radiotherapy" techniques by incorporation of novelimaging methodologies. To date, the bulk of my work has focused on  improving multimodality (e.g. PET-CT, MRI,US) imaging for target delineation in the multi-institutional setting.


I have specific and singular expertise in imaging physicsand human imaging trial design, analysis and execution, acquired as part of myPhD and post-doctoral training. As a formal component of the MD Anderson K12Paul Calabresi Clinical Trial training program, in addition to directinstruction in clinical trial design and imaging informatics, I  have completed ABME board subspecialtycertification in Clinical Informatics in addition to primary ABR certificationin Radiation Oncology. As a radiation oncologist with informatics certificationand formal medical physics training, I am uniquely positioned to executeimage-guided radiotherapy clinical trials.


My long-term goal is to execute a practice-pattern changing,cooperative group-supported radiotherapy trial which incorporates aquantitative imaging biomarker for risk stratification, adaptive therapyplanning, and/or surrogate endpoint use in head and neck cancer.

Research Interests

My research focuses on development and implementation of multimodality imaging methodologies (CT/PET/MRI) for treatment stratification, target delineation, treatment delivery and response assessment in head and neck cancers.

Education & Training

Degree-Granting Education

2011 University of Texas Health Science Center At San Antonio, San Antonio, TX, PHD, Radiological Sciences (Human Imaging)
2006 University of Texas Health Science Center at San Antonio, San Antonio, TX, MD, Medicine
1998 Abilene Christian University, Abilene, TX, BS, Psychology/Biology (Pre-Medicine)

Postgraduate Training

2007-2011 Clinical Residency, Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX
2006-2007 Clinical Internship, Categorical, University Hospital/University of Texas Health Science Center at San Antonio, San Antonio, TX

Board Certifications

2015 American Board of Preventive Medicine (Clinical Informatics)
2013 American Board of Radiology

Honors and Awards

2013-present M. D. Anderson K12 Paul Calabresi Program in Clinical Oncology, National Cancer Institute
2011-2013 Coltman Fellowship Award, Hope Foundation
2011-2012 Young Investigator Award, American Society of Clinical Oncology Conquer Cancer Foundation
2010-2011 Clinical Research Loan Repayment (Renewal L30 CA136381-02), National Institutes of Health
2009 Annual Meeting Travel Grant, American Radium Society
2009 ESTRO Technology Transfer Grant, European Society for Therapeutic Radiology and Oncology, European Society of Radiation Oncology/Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis
2009 Travel Scholarship, University Hospital House Staff Council, University of Texas Health Science Center at San Antonio
2008-2010 Clinical Research Loan Repayment (L30 CA136381-01), National Institutes of Health
2008-2009 Product Development Support Grant, Society for Imaging Informatics in Medicine
2007-2009 Multidisciplinary Training Grant in Human Imaging (T32 EB000817), National Institute of Biomedical Imaging and Bioengineering
2007-2008 Research Travel Fellowship, European Association for Cancer Research
2007-2008 RSNA Research Resident/Fellow Grant (RR0732), Radiological Society of North America Research & Education Foundation
2007 Resident Travel Award, American Brachytherapy Society Annual Meeting
2007 Travel Scholarship, University Hospital House Staff Council, University of Texas Health Science Center at San Antonio
2005-2006 Carolyn L. Kuckein Memorial Medical Student Research Scholarship, Alpha Omega Alpha Medical Student Honor Society
2005 Annual Gastrointestinal Oncology Conference Travel Grant, International Society for Gastrointestinal Oncology
2005 Translational Research in Radiation Oncology Symposium Travel Grant, American Society of Therapeutic Radiology and Oncology
2004 First Place UTHSCSA Medical Student Research Day Poster Competition, Medical Dean's Office, University of Texas Health Science Center at San Antonio
2003-2004 Bartter Scholar, University of Texas Health Science Center at San Antonio/Frederic C. Bartter General Clinical Research Center
2003-2004 Mentored Medical Student Clinical Research Program Award, National Institutes of Health/National Center for Research Resources/Frederic C. Bartter General Clinical Research Center, University of Texas Health Science Center at San Antonio
2003-2004 Student Fellowship Grant, Society of Nuclear Medicine
2003 Medical Student Research Stipend Award,, American Cancer Society/Medical Dean's Office, University of Texas Health Science Center at San Antonio
2003 Outstanding Medical Student, Department of Radiation Oncology, University of Texas Health Science Center at San Antonio
2003 Travel Scholarship, 1st International Target Delineation Symposium for IMRT/3D CRT Treatment Planning, University of Texas M.D. Anderson Cancer Center
2002-2003 Medical Student Departmental Grant, Radiological Society of North America
2000 Medical Student Section Travel Grant, Texas Medical Association

Selected Publications

Peer-Reviewed Original Research Articles

1. Rosenthal DI, Fuller CD, Peters LJ, Thames HD. Final Report of Radiation Therapy Oncology Group Protocol 9003: Provocative, but Limited Conclusions From Exploratory Analyses. Int J Radiat Oncol Biol Phys 92(4):715-7, 7/2015. PMID: 26104925.
2. Holliday EB, Ahmed AA, Jagsi R, Stentz NC, Woodward WA, Fuller CD, Thomas CR. Pregnancy and Parenthood in Radiation Oncology, Views and Experiences Survey (PROVES): Results of a Blinded Prospective Trainee Parenting and Career Development Assessment. Int J Radiat Oncol Biol Phys 92(3):516-24, 7/2015. e-Pub 4/2015. PMID: 25892584.
3. Takiar V, Ma D, Garden AS, Li J, Rosenthal DI, Beadle BM, Frank SJ, Fuller CD, Gunn GB, Morrison WH, Hutcheson K, El-Naggar AK, Gold KA, Kupferman ME, Phan J. Disease control and toxicity outcomes for T4 carcinoma of the nasopharynx treated with intensity modulated radiotherapy. Head Neck. e-Pub 5/2015. PMID: 25994561.
4. Rosenthal DI, Mohamed AS, Weber RS, Garden AS, Sevak PR, Kies MS, Morrison WH, Lewin JS, El-Naggar AK, Ginsberg LE, Kocak-Uzel E, Ang KK, Fuller CD. Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey. Cancer 121(10):1608-19, 5/2015. e-Pub 1/2015. PMCID: PMC4424158.
5. Awan M, Dyer BA, Kalpathy-Cramer J, Bongers E, Dahele M, Yang J, Walker GV, Thaker NG, Holliday E, Bishop AJ, Thomas CR, Rosenthal DI, Fuller CD. Auto-segmentation of the brachial plexus assessed with TaCTICS - A software platform for rapid multiple-metric quantitative evaluation of contours. Acta Oncol 54(4):1-5, 4/2015. e-Pub 10/2014. PMID: 25279958.
6. Tao R, Ma D, Takiar V, Frank SJ, Fuller CD, Gunn GB, Beadle BM, Morrison WH, Rosenthal DI, Edson MA, Esmaeli B, Kupferman ME, Hanna EY, Garden AS, Phan J. Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy. Head Neck. e-Pub 3/2015. PMID: 25782700.
7. Bishop AJ, Garden AS, Gunn GB, Rosenthal DI, Beadle BM, Fuller CD, Levy LB, Gillenwater AM, Kies MS, Esmaeli B, Frank SJ, Phan J, Morrison WH. Merkel cell carcinoma of the head and neck: Favorable outcomes with radiotherapy. Head Neck. e-Pub 2/2015. PMID: 25645649.
8. Garden AS, Gunn GB, Hessel A, Beadle BM, Ahmed S, El-Naggar AK, Fuller CD, Byers LA, Phan J, Frank SJ, Morrison WH, Kies MS, Rosenthal DI, Sturgis EM. Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer. Cancer 120(19):3082-8, 10/2014. e-Pub 6/2014. PMCID: PMC4172550.
9. Sheu T, Fuller CD, Mendoza TR, Garden AS, Morrison WH, Beadle BM, Phan J, Frank SJ, Hanna EY, Lu C, Cleeland CS, Rosenthal DI, Gunn GB. Nomogram for Predicting Symptom Severity during Radiation Therapy for Head and Neck Cancer. Otolaryngol Head Neck Surg 151(4):619-26, 10/2014. e-Pub 8/2014. PMCID: PMC4184965.
10. Mavroidis P, Giantsoudis D, Awan MJ, Nijkamp J, Rasch CR, Duppen JC, Thomas CR, Okunieff P, Jones WE, Kachnic LA, Papanikolaou N, Fuller CD, Southwest Oncology Group Radiation Oncology Committee. Consequences of anorectal cancer atlas implementation in the cooperative group setting: Radiobiologic analysis of a prospective randomized in silico target delineation study. Radiother Oncol 112(3):418-24, 9/2014. e-Pub 7/2014. PMCID: PMC4258107.
11. Walker GV, Awan M, Tao R, Koay EJ, Boehling NS, Grant JD, Sittig DF, Gunn GB, Garden AS, Phan J, Morrison WH, Rosenthal DI, Mohamed AS, Fuller CD. Prospective randomized double-blind study of atlas-based organ-at-risk autosegmentation-assisted radiation planning in head and neck cancer. Radiother Oncol 112(3):321-5, 9/2014. e-Pub 9/2014. PMCID: PMC4252740.
12. Awan MJ, Mohamed AS, Lewin JS, Baron CA, Gunn GB, Rosenthal DI, Holsinger FC, Schwartz DL, Fuller CD, Hutcheson KA. Late radiation-associated dysphagia (late-RAD) with lower cranial neuropathy after oropharyngeal radiotherapy: A preliminary dosimetric comparison. Oral Oncol 50(8):746-52, 8/2014. e-Pub 6/2014. PMCID: PMC4158823.
13. Kocak-Uzel E, Gunn GB, Colen RR, Kantor ME, Mohamed AS, Schoultz-Henley S, Mavroidis P, Frank SJ, Garden AS, Beadle BM, Morrison WH, Phan J, Rosenthal DI, Fuller CD. Beam path toxicity in candidate organs-at-risk: Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy. Radiother Oncol 111(2):281-8, 5/2014. e-Pub 4/2014. PMCID: PMC4063998.
14. Holliday EB, Jagsi R, Wilson LD, Choi M, Thomas CR, Fuller CD. Gender differences in publication productivity, academic position, career duration, and funding among U.S. academic radiation oncology faculty. Acad Med 89(5):767-73, 5/2014. PMID: 24667510.
15. Choi M, Holliday EB, Jagsi R, Wilson LD, Fuller CD, Thomas CR. Citation-based Estimation of Scholarly Activity Among Domestic Academic Radiation Oncologists: Five-Year Update. J Radiat Oncol 3(1):115-122, 3/2014. PMCID: PMC3963283.
16. Holliday EB, Jagsi R, Thomas CR, Wilson LD, Fuller CD. Standing on the Shoulders of Giants: Results From the Radiation Oncology Academic Development and Mentorship Assessment Project (ROADMAP). Int J Radiat Oncol Biol Phys 88(1):18-24, 1/2014. e-Pub 11/2013. PMCID: PMC4085773.
17. Baron CA, Awan MJ, Mohamed AS, Akel I, Rosenthal DI, Gunn GB, Garden AS, Dyer BA, Court L, Sevak PR, Kocak-Uzel E, Fuller CD. Estimation of daily interfractional larynx residual setup error after isocentric alignment for head and neck radiotherapy: quality assurance implications for target volume and organs-at-risk margination using daily CT on- rails imaging. J Appl Clin Med Phys 16(1):5108, 2014. e-Pub 1/2014. PMID: 25679151.
18. Gunn GB, Mendoza TR, Fuller CD, Gning I, Frank SJ, Beadle BM, Hanna EY, Lu C, Cleeland CS, Rosenthal DI. High Symptom Burden Prior to Radiation Therapy for Head and Neck Cancer: A Patient-Reported Outcomes Study. Head Neck 35(10):1490-8, 10/2013. e-Pub 11/2012. PMCID: PMC3788079.
19. Rana S, Holliday EB, Jagsi R, Wilson LD, Choi M, Thomas CR, Fuller CD. Scholastic activity among radiation oncology residents at US academic institutions: a benchmark analysis. J Cancer Educ 28(3):541-6, 9/2013. PMID: 23828146.
20. Gunn GB, Debnam JM, Fuller CD, Morrison WH, Frank SJ, Beadle BM, Sturgis EM, Glisson BS, Phan J, Rosenthal DI, Garden AS. The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Cancer 119(17):3162-9, 9/2013. e-Pub 6/2013. PMCID: PMC3775996.
21. Awan M, Kalpathy-Cramer J, Gunn GB, Beadle BM, Garden AS, Phan J, Holliday E, Jones WE, Maani E, Patel A, Choi J, Clyburn V, Tantiwongkosi B, Rosenthal DI, Fuller CD. Prospective Assessment of an Atlas-Based Intervention Combined With Real-Time Software Feedback in Contouring Lymph Node Levels and Organs-at-Risk in the Head and Neck: Quantitative Assessment of Conformance to Expert Delineation. Pract Radiat Oncol 3(3):186193, 7/2013. PMCID: PMC3706296.
22. Awan M, Kalpathy-Cramer J, Gunn GB, Beadle BM, Garden AS, Phan J, Holliday E, Jones WE, Maani E, Patel A, Choi J, Clyburn V, Tantiwongkosi B, Rosenthal DI, Fuller CD. Prospective assessment of an atlas-based intervention combined with real-time software feedback in contouring lymph node levels and organs-at-risk in the head and neck: Quantitative assessment of conformance to expert delineation. Pract Radiat Oncol 3(3):186-93, Jul-Sep, 7/2013. e-Pub 12/2012. PMID: 24674363.
23. Ramahi E, Choi J, Fuller CD, Eng TY. Merkel cell carcinoma. Am J Clin Oncol 36(3):299-309, 6/2013. PMCID: PMC3121923.
24. Wang SJ, Wissel AR, Luh JY, Fuller CD, Kalpathy-Cramer J, Thomas CR. Individualized Estimation of Conditional Survival for Patients with Head and Neck Cancer. Annals of Surgical Oncology, 2011.
25. Fuller CD, Nijkamp J, Duppen J, Rasch CRN, Thomas CR, Wang SJ, Okunieff P, Jones WE, Baseman DB, Patel S, Demandante CGN, Harris AM, Smith BD, Katz AW, McGann C, Harper JL, Chang DT, Smalley S, Marshall DT, Goodman KA, Papanikolaou N, Kachnic LA. Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting,. Int J Radiat Oncol Biol Phys. 79(2):481-9, 2011.
26. Rosenthal DI, Fuller CD, Barker JL, Mason B, Garcia JA, Lewin J, Holsinger FC, Stasney R, Frank SJ, Schwartz DL, Morrison WH, Garden AS, Ang KK. Simple Carotid-Sparing IMRT Technique and Preliminary Experience for T1-2 Glottic Cancer. Int J Radiat Oncol Biol Phys. 77(2):455-61, 6/2010. PMID: 19679406.
27. Kalpathy-Cramer J, Fuller CD. Target Contour Testing/Instructional Computer Software (TaCTICS): A Novel Training and Evaluation Platform for Radiotherapy Target Delineation. American Informatics Association Annual Symposium Proceedings:361-365, 2010.
28. Fuller CD, Wang SJ, Choi M, Czito BG, Cornell J, Welzel T, McGlynn K, Luh J, Thomas CR. Multimodality therapy for locoregional extrahepatic cholangiocarcinoma: a population based analysis. Cancer 27(115):5175-5183, 2009.
29. Rosenthal DI, Chambers MS, Fuller CD, Rebueno NC, Garcia J, Kies MS, Morrison WH, Ang KK, Garden AS. Beam Path Toxicities to Non-Target Structures during Intensity-Modulated Radiation Therapy for Head and Neck Cancers. Int J Radiat Oncol Biol Phys 72(3):747-755, 11/2008. e-Pub 5/2008. PMID: 18455324.
30. Fuller CD, Schillerstrom JE, Jones WE, Boersma M, Royall DR, Fuss M. Prospective Evaluation of Pretreatment Executive Cognitive Impairment and Depression in Patients Referred for Radiotherapy. Int J Radiat Oncol Biol Phys 72(2):529-533, 10/2008. e-Pub 4/2008. PMID: 18411001.
31. Wang SJ, Fuller CD, Kim JS, Sittig DF, Thomas CR, Ravdin P. A Prediction Model for Estimating the Survival Benefit of Adjuvant Radiotherapy. Am J Clin Oncol 26(13):2112-7, 2008.
32. Fuller CD, Wang SJ, Thomas CR, Hoffman HT, Weber RS, Rosenthal DI. Conditional survival in head and neck squamous cell carcinoma: results from the SEER dataset 1973-1998. Cancer 109(7):1331-43, 4/2007. PMID: 17326199.
33. Fuss M, Wong A, Fuller CD, Salter BJ, Fuss C, Thomas CR. Image-guided intensity-modulated radiotherapy for pancreatic carcinoma. Gastrointest Cancer Res 1(1):2-11, 1/2007. PMCID: PMC2632515.
34. Wang SJ, Emery R, Fuller CD, Kim JS, Sittig DF, Thomas CR. Conditional survival in gastric cancer: a SEER database analysis. Gastric Cancer 10(3):153-8, 2007. e-Pub 9/2007. PMID: 17922092.
35. Fuller CD, Thomas CR, Wong A, Cavanaugh SX, Salter BJ, Herman TS, Fuss M. Image-guided intensity-modulated radiation therapy for gallbladder carcinoma. Radiother Oncol 81(1):65-72, 10/2006. e-Pub 9/2006. PMID: 16971012.
36. Fuller CD, Thomas CR, Schwartz S, Golden N, Ting J, Wong A, Erdogmus D, Scarbrough TJ. Method comparison of ultrasound and kilovoltage x-ray fiducial marker imaging for prostate radiotherapy targeting. Phys Med Biol 51(19):4981-93, 10/2006. e-Pub 9/2006. PMID: 16985282.
37. Eng TY, Boersma MK, Fuller CD, Luh JY, Siddiqi A, Wang S, Thomas CR. The role of radiation therapy in benign diseases. Hematol Oncol Clin North Am 20(2):523-57, 4/2006. PMID: 16730305.
38. Rosenthal DI, Fuller CD, Machtay M, Algazy KM, Meyer DM, Kaiser LR, Yardley DA, Loiacano ME, Carbone DP. Phase I study of Paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced non-small cell lung cancer. J Thorac Oncol 1(1):38-45, 1/2006. PMID: 17409825.
39. Jones K, Fuller CD, Luh JY, Childs CC, Miller AR, Tolcher AW, Herman TS, Thomas CR. Case report and summary of literature: giant perineal keloids treated with post-excisional radiotherapy. BMC Dermatol 6:7, 2006. e-Pub 4/2006. PMCID: PMC1562439.
40. Rassiah-Szegedi P, Salter BJ, Fuller CD, Blough M, Papanikolaou N, Fuss M. Monte Carlo characterization of target doses in stereotactic body radiation therapy (SBRT). Acta Oncol 45(7):989-94, 2006. PMID: 16982568.
41. Esquivel C, Fuller CD, Waggener RG, Wong A, Meltz M, Blough M, Eng TY, Thomas CR. Novel low-kVp beamlet system for choroidal melanoma. Radiat Oncol 1:36, 2006. e-Pub 9/2006. PMCID: PMC1586203.
42. Luh JY, Eng TY, Fuller CD. Minimizing urinary bladder radiation dose during brachytherapy for carcinoma of the cervix using balloon inflation technique: In regard to Malaker et al. (Int J Radiat Oncol Biol Phys 2005;61:257-266). Int J Radiat Oncol Biol Phys 62(3):944; author reply 944-5, 7/2005. PMID: 15936589.
43. Koshy MC, Landry JC, Cavanaugh SX, Fuller CD, Willett CG, Abrams RA, Hoffman JP, Thomas CR. A challenge to the therapeutic nihilism of ESPAC-1. Int J Radiat Oncol Biol Phys 61(4):965-6, 3/15/2005. PMID: 15752874.
44. Eng TY, Naguib M, Fuller CD, Jones WE, Herman TS. Treatment of recurrent Merkel cell carcinoma: an analysis of 46 cases. Am J Clin Oncol 27(6):576-83, 12/2004. PMID: 15577435.
45. Eng TY, Boersma MG, Fuller CD, Cavanaugh SX, Valenzuela F, Herman TS. Treatment of merkel cell carcinoma. Am J Clin Oncol 27(5):510-5, 10/2004. PMID: 15596922.
46. Fuller CD, Diaz I, Cavanaugh SX, Eng TY. In vivo dose perturbation effects of metallic dental alloys during head and neck irradiation with intensity modulated radiation therapy. Oral Oncol 40(6):645-8, 7/2004. PMID: 15063394.
47. Eng TY, Fuller CD, Jagirdar J, Bains Y, Thomas CR. Thymic carcinoma: state of the art review. Int J Radiat Oncol Biol Phys 59(3):654-64, 7/2004. PMID: 15183468.
48. Eng TY, Fuller CD, Cavanaugh SX, Blough MM, Sadeghi A, Herman T. Significant rectal and bladder dose reduction via utilization of Foley balloon catheters in high-dose-rate tandem and ovoid intracavitary brachytherapy of the uterine cervix. Int J Radiat Oncol Biol Phys 59(1):174-8, 5/2004. PMID: 15093914.

Invited Articles

1. Fuller CD. Multidisciplinary management of head and neck cancer. Head & Neck, DOI:10.1002/hed.23179. In Press.

Letters to the Editor

1. Garden AS, Fuller CD. Letter to the Editor regarding transoral laser microsurgery followed by radiotherapy in advanced oropharyngeal cancer. Head Neck 36(11):1674-5, 11/2014. e-Pub 9/2014. PMID: 24954499.

Grant & Contract Support

Title: Pre-clinical study of active magnetic field biological influence on radiation responses of human solid cancers
Funding Source: Elekta Limited
Role: Co-Principal Investigator
Principal Investigator: Clifton D. Fuller
Duration: 7/1/2013 - 6/30/2014

Last updated: 7/31/2015