Cynthia R. Lockworth, DVM, DACLAM
Department of Veterinary Medicine and Surgery, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Veterinary Medicine and Surgery, Division of Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | Texas A&M University, College Station, Texas, US, Doctor of Veterinary Medicine, DVM |
| 1995 | Texas A&M University, College Station, Texas, US, Veterinary Science, BS |
| 1995 | University of Houston, Houston, Texas, US, Anthropology, BS |
| 1995 | University of Houston, Houston, Texas, US, Bioscience, BS |
Postgraduate Training
| 2005-2007 | Clinical Fellowship, Laboratory Animal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Board Certifications
| 2017 | Diplomate, American College of Laboratory Animal Medicine |
Experience & Service
Academic Appointments
Associate Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2023
Assistant Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, 2011 - 2017
Instructor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2011
Administrative Appointments/Responsibilities
Section Chief, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - Present
Section Chief ad interim, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2017
Other Appointments/Responsibilities
Clinical Veterinarian, Petvet Animal Hospital, Houston, TX, 2001 - 2005
Clinical Veterinarian, Voss Road Animal Hospital, Houston, TX, 2000 - 2001
Clinical Veterinarian, Grant Road Animal Clinic, Houston, TX, 1998 - 2000
Institutional Committee Activities
Member, Faculty Academic Review Committee, 2022 - Present
Voting member, Mid-Career Faculty Committee, 2021 - Present
Committee member, Veterinary Medicine & Surgery Chair Advisory Committee, 2018 - 2019
Alternate member, Institutional Animal Care and Use Committee, 2017 - Present
Alternate member, Radiation Safety Committee, 2017 - Present
Senator, Faculty Senate, 2015 - 2018
Member, Faculty Academic Review Committee, 2015 - 2018
Voting member, Institutional Biosafety Committee, 2014 - Present
Voting member, Radiation Safety Committee, 2013 - 2017
Alternate member, Institutional Biosafety Committee, 2013 - 2014
Alternate member, Radiation Safety Committee, 2009 - 2013
Alternate member, Institutional Animal Care and Use Committee, 2008 - 2015
Honors & Awards
| 2017 | First Place Poster in Animal Husbandry/Management, American Association of Laboratory Animal Science National Meeting |
| 2016 | Letter of Commendation, Institutional Animal Care and Use Committee, MD Anderson Cancer Center |
| 2016 | First Place Poster in Animal Welfare, Training, and the 3Rs, American Association of Laboratory Animal Science National Meeting |
| 2008 | Outstanding Clinical Veterinarian Award, Charles Rivers Laboratories |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tatara AM, Wurster S, Lockworth CR, Albert ND, Walsh TJ, Mikos AG, Eisenhoffer GT, Kontoyiannis DP. Immunosuppressed Adult Zebrafish Model of Mucormycosis. Antimicrob Agents Chemother 62(11), 2018. e-Pub 2018. PMID: 30150461.
- Hayes-Jordan AA, Ma X, Menegaz BA, Lamhamedi-Cherradi SE, Kingsley CV, Benson JA, Camacho PE, Ludwig JA, Lockworth CR, Garcia GE, Craig SL. Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor. Neoplasia 20(5):524-532, 2018. e-Pub 2018. PMID: 29626752.
- Lockworth CR, Rodriguez T, Schmit MS, Hill LR. The Power of a Positive Approach to Realizing Change in an Animal Facility. Lab Anim (NY) 47(3):59, 2018. PMID: 29483686.
- Kendricks AL, Pageon LR, Craig SL, Wen Y, Sood AK, Lockworth CR. Pathology in Practice: Severe Polyarthritis with Implanted Ovarian Carcinoma Cells in a Mouse. J Am Vet Med Assoc 249(10):1149-1151, 2016. PMID: 27823375.
- Lockworth CR, Kim SJ, Liu J, Palla SL, Craig SL. Effect of Enrichment Devices on Aggression in Manipulated Nude Mice. J Am Assoc Lab Anim Sci 54(5):731-6, 2015. PMID: 26632782.
- Monts de Oca NA, Laughlin M, Jenkins J, Lockworth CR, Bolton ID, Brammer DW. Comparison of Indoor Air Quality between 2 Ventilation Strategies in a Facility Housing Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci 54(5):527-35, 2015. PMID: 26424251.
- Matthias N, Robinson MA, Crook R, Lockworth CR, Goodwin BS. Local cryoanalgesia is effective for tail-tip biopsy in mice. J Am Assoc Lab Anim Sci 52(2):171-5, 2013. PMID: 23562100.
- Matthias N, Lockworth CR, Zhang F, Lee MH, Yeung SC, Tsai KY, Hamir AN. Multiple cystic sweat gland tumors in transgenic mice. Comp Med 62(1):27-30, 2012. PMID: 22330648.
- Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, Hu P, Estrov Z, Bueso-Ramos CE, Darnay BG. Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice. PLoS One 7(12):e51228, 2012. e-Pub 2012. PMID: 23251462.
- Tran QT, Lockworth CR, Craig SL. Managing a pending IBC approval. IBC approval not substantive. Lab Anim (NY) 40(10):296-8, 2011. e-Pub 2011. PMID: 22358203.
- Lockworth CR, Craig SL, Liu J, Tinkey PT. Training veterinary care technicians and husbandry staff improves animal care. J Am Assoc Lab Anim Sci 50(1):84-93, 2011. PMID: 21333169.
Invited Articles
- Wilson LA, Miller JJ, Work RK, Piotrowski SL, Kasper FK, Young S, Lai SY, Lockworth CR, Hill LR. Novel Diet Regimen for lagomorphs in a Compromised Oral Wound Healing Study. Laboratory Animal Science Professional, 2018. PMID: None.
- Lockworth CR, Monts de Oca NA. Training Toolbox: The Constructs of an Effective Training Program in Animal Health. ALN. e-Pub 2017. PMID: None.
- Craig S, Lockworth C, Naff K. Questions for the investigator. Monitor matters. Lab Anim (NY) 35(9):16-7, 2006. PMID: 17008901.
Manuals, Teaching Aids, Other Teaching Publications
- Lockworth CR, Monts de Oca NA. Rodent Clinical Conditions Library. Charles River Laboratories, 2017.
- Lockworth CR, Monts de Oca NA. Common Rodent Health Conditions Poster. Charles River Laboratories, 2015.
- Lockworth C. Algorithm for Anesthetic Emergencies in Large Animals. None, 2012.
- Lockworth C. Health Management Algorithm for Rodents. None, 2009.
- Lockworth CR, Oca MD, NA. Common Health Conditions of Mice. American Association of Laboratory Animal Science, AALAS Learning Library.
- Lockworth CR. A case of chronic regurgitation in a pig. None.
Other Articles
- Pesek, A, Lockworth CR Management of a Water Outage in a Large Rodent Facility. Laboratory Animal Science Professional, 2022. PMID: None.
- Rodriguez E, Duran A, Rodriguez Jr T, Collins T, Lockworth CR Sign of the Times: Saving the Lives of Mice. Laboratory Animal Science Professional, 2017. PMID: None.
- Lockworth, CR, Monts de Oca N Rodent Health: A Picture is Worth a Thousand Words. Laboratory Animal Science Professional 4(2):46-47, 2016. PMID: None.
- Monts de Oca N, Brammer DW, Laughlin MS, Jenkins JT, Lockworth CR Aircuity Applications: Energy Efficiency of a Large Animal Vivarium: A University of Houston Research Study. None, 2015. PMID: None.
Abstracts
- Fowlkes N, Whitley E, Gagea M, Swain J, Lockworth C, Ueno N, Jensen V. Macrophage Activation Syndrome in Humanized NOD.Cg-Prkdc^SCIDIl2rg^tm1wjl/SzJ (NSG) Expressing Human Cytokines IL-3, GM-CSF, and SCF (NSG-SGM3) After Engraftment with Human CD34+ Hematopoietic Stem Cells. American College of Veterinary Pathologists Conference. e-Pub 2019. PMID: None.
- Lockworth CL, Pesek AT. Glass Half Full: Hydrating Mice Without Water. American Association of Laboratory Animal Science Conference. e-Pub 2019. PMID: None.
- Lockworth CR, Pesek AT. When Your Mouse House is Dry: Strategies and Solutions for the Successful Management of a Water Outage. Conference of Excellence. e-Pub 2019. PMID: None.
- Fowlkes NW, Swain J, Gagea M, Lockworth C, Tinkey P, Jensen V, Whitley EM. Cutaneous and Gastrointestinal Dysbiosis in Immunodeficient Mice. Experimental Biology Conference. e-Pub 2019. PMID: None.
- Lockworth CR, Pesek AT. High and Dry: Navigating the Waters of a Water Outage. Texas Branch American Association for Laboratory Animal Science Conference. e-Pub 2019. PMID: None.
- Lockworth CR. Common Rodent Health Conditions: Practical Tips for Identification and Management. 12th TALAS International Conference. e-Pub 2018. PMID: None.
- Wilson LA, Miller JJ, Work RK, Piotrowski SL, Kasper FK, Young S, Lai SY, Lockworth CR, Hill LR. Novel Diet Regimen for Lagomorphs in a Compromised Oral Wound Healing Study. American Association of Laboratory Animal Science Conference. e-Pub 2017. PMID: None.
- Chambers A, Graika K, Hill LR, Lockworth CR. Hopping Toward the Future. American Association of Laboratory Animal Science Conference. e-Pub 2017. PMID: None.
- Lockworth CR, Schmit MS, Rodriguez Jr T, Hill LR. Behavior Modification of Personnel Through the Use of Positive Reinforcement. American Association of Laboratory Animal Science Conference. e-Pub 2017. PMID: None.
- Lockworth CR, Rodriguez Jr T, Schmit MS, Hill LR. Food for Thought: Changing Feeding Practices Improves Efficiency. American Association of Laboratory Animal Science Conference. e-Pub 2017. PMID: None.
- Lockworth CR, Monts de Oca NA. Rodent health: An illustrative compendium for the identification and management of clinical conditions in mice. Charles River Short Course. e-Pub 2017. PMID: None.
- Lockworth CR. A Training Tale: Construction of a Rodent Health Training Program. MD Anderson Education Week. e-Pub 2017. PMID: None.
- Lockworth CR, Monts de Oca N. The A to Z of Rodent Health Conditions. Texas Branch American Association for Laboratory Animal Science. e-Pub 2017. PMID: None.
- Lockworth CR, Monts de Oca N. Implements of Education: The Building Blocks of an Effective Rodent Health Training Program. Texas Branch American Association for Laboratory Animal Science. e-Pub 2017. PMID: None.
- Graika K, Toomey D, Rodriguez T, Monts de Oca N, Cabrera M, Lockworth CR. Evolution of a Nonhuman Primate Enrichment Program. Texas Branch American Association for Laboratory Animal Science. e-Pub 2017. PMID: None.
- Lockworth, CR, Monts de Oca N. Tools of the Training Trade: Mechanics of Improved Animal Health. American Association of Laboratory Animal Science Conference. e-Pub 2016. PMID: None.
- Graika K, Toomey D, Rodriguez Jr T, Monts de Oca N, Cabrera M, Lockworth C. Evolution of a Nonhuman Primate Enrichment Program. American Association of Laboratory Animal Science Conference. e-Pub 2016. PMID: None.
- Craig S, Lockworth C. Zebrafish Colony Set-up, Routine Maintenance and Some Potential Common Diseases. 10th TALAS International Symposium, 2016. e-Pub 2016. PMID: None.
- Craig S, Lockworth C. Pain Scoring and Humane Endpoint. 10th TALAS International Symposium, 2016. PMID: None.
- Lockworth, CR, Oca MD, N. Identification and Management of Common Clinical Conditions in Laboratory Rodents. Charles River Short Course, 2016. PMID: None.
- Hayes-Jordan A, MA X, Kingsley C, Lockworth CR, Craig SL. Death Receptor Expression and sensitivity targeted in desmoplastic small round cell tumor. 47 Congress of the Inernational Society of Paediatric Oncology (SIOP). e-Pub 2015. PMID: None.
- Tatara AM, Albert ND, Lockworth CR, Swindell EC, Mikos AG, Kontoyiannis DP. Adult Zebrafish as a Model Host to Study Mucormycosis. Interscience Conference on Antimicrobial Agents and Chemotherapy and International Congress of Chemotherapy, 2015. PMID: None.
- Levy D, Craig S, McArthur M, Stange D, Lockworth C. Is There More to Corynebacterium bovis?. American Association Laboratory Animal Science, Texas Branch Conference, 2015. PMID: None.
- Kizer AA, Lockworth CR, Bogdanske JJ, Gibbons C, Uthamanthil RK. Anatomy of a laboratory animal training program. American Association of Laboratory animal Science Conference, 2014. PMID: None.
- Kendricks A, Pageon LR, Wen Y, Craig S, Lockworth CR. Severe polyarthritis with implanted ovarian carcinoma cells in a mouse. American Association for Laboratory Animal Science, Texas Branch Conference, 2014. PMID: None.
- Lockworth C. Anesthetic Emergency Algorithms for Improved Crises Management. American Association of Laboratory Animal Science Conference, 2013. e-Pub 2013. PMID: None.
- Bird K, Pageon L, Lockworth CR. Investigation of Acute Wounds to the Lower Extremeties of Immunodeficient Post-weanling CD4CREXCISFB^#7 Mice. James Steele Conference on Diseases in Nature Transmissible to Man, 2013. PMID: None.
- Anderson J, Moore L, Lockworth CR. Algorithm for Veterinary Anesthetic Emergencies in the Laboratory Animal Setting. Educational Week Poster Competition, MD Anderson Cancer Center, 2013. PMID: None.
- Monts de Oca N, Lockworth, CR. A case of chronic regurgitation in a pig. American Association for Laboratory Animal Science, Texas Branch Conference, 2013. PMID: None.
- Bird K, Pageon L, Lockworth C. Investigation of Acute Wounds to the Lower Extremeties of Immunodeficient Post-weanling CD4CREXCISFB^#7 Mice. American Association of Laboratory Animal Science Conference, 2012. PMID: None.
- Lockworth C, Craig S. Animal Care Training in the Face of Colony Expansion. American Association of Laboratory Animal Science Conference, 2011. PMID: None.
- Monts de Oca N, Lockworth C. Mysterious Subcutaneous Masses in Nude Mice. American Veterinary Medical Association Conference, 2011. PMID: None.
- Matthias N, Lockworth C. Multiple Cystic Sweat Gland Tumors: a Transgenic Mouse Model. American Veterinary Medical Association Conference 62(1):1-4, 2011. PMID: None.
- Lockworth C, Craig S. Veterinary Staff Training Program Improves Animal Health. ACLAM Forum, 2011. PMID: None.
- Lockworth C, Craig S. Training Program Forges a Path to Improved Animal Health. Educational Week Poster Competition, MD Anderson Cancer Center, 2011. PMID: None.
- Lockworth C, Gagea M, Craig S, Tinkey P. Xenopus Zebra. American Veterinary Medical Association Conference, 2010. PMID: None.
- Lockworth C. Blood Gas Analysis in Swine. Texas Branch American Association for Laboratory Animal Science, 2006. PMID: None.
Grant & Contract Support
| Title: | Cancer Center Support (CORE) Grant |
| Funding Source: | NIH/NCI |
| Role: | Other personnel |
| Title: | Standardization of husbandry practices in Xenopus laevis using the corticosterone stress response |
| Funding Source: | American Association for Laboratory Animal Science |
| Role: | PI |
| Title: | Standardization of husbandry practices in Xenopus laevis using the corticosterone stress response |
| Funding Source: | American Association for Laboratory Animal Science |
| Role: | Co-PI |
| Title: | The Gulf Coast Consortium Veterinary Training Program in Comparative Medicine |
| Funding Source: | NIH/NCRR |
| Role: | Veterinary Mentor |
| Title: | Standardization of husbandry practices in Xenopus laevis using the corticosterone stress response |
| Funding Source: | ACLAM Foundation |
| Role: | PI |
| Title: | Molecular Dissection of host–environment interaction in gastric tumorigenesis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
Patient Reviews
CV information above last modified November 21, 2024