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David R. Grosshans, M.D., Ph.D.

Department of Radiation Oncology, Division of Radiation Oncology

About Dr. Grosshans

Dr. Grosshans holds a faculty position within the Departments of Radiation Oncology and Experimental Radiation Oncology at MD Anderson Cancer Center. Clinically, as a radiation oncologist, he treats adult and pediatric patients requiring proton therapy. He is a physician scientist and devotes a significant amount of time to research. His research interests are driven by his clinical experience. He has a special expertise, both research and clinical, in particle therapy, including the use of multi-field optimized Intensity Modulated Proton Therapy (IMPT). His lab's ongoing bench research includes investigations of biologic effect variability in proton therapy, including differential DNA damage as a function of physical factors, as well as radiation effects on nonreplicative cell types including neurons. Dr. Grosshans has extensive experience in both in vitro and in vivo radiation biologic effect models and has numerous ongoing collaborations with faculty in radiation physics, neuro-immunology as well as neuroscience investigators at Baylor and Texas Children's Hosiptal. Dr. Grosshans has also extended his work to include the study of particles heavier than protons, including helium and carbon ions and have numerous ongoing collaborations with centers in Europe and Asia.

Primary Appointment

Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Adjunct Professor, Department of Pediatric Radiology, Texas Children's Hospital, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004	University of Colorado, Denver, Colorado, US, MD
2002	University of Colorado, Denver, Colorado, US, Pharmacology, Ph.D
1995	University of Colorado, Boulder, Colorado, US, Molecular, Cellular, & Developmental Biology, BA

Postgraduate Training

2005-2009	Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
2004-2005	Clinical Internship, Medical Internship, Presbyterian Saint Luke's Hospital, Denver, Colorado

Board Certifications

2010	American Board of Radiology

Experience & Service

Academic Appointments

Adjunct Professor, Department of Pediatric Radiology, Texas Children's Hospital, Houston, TX, 2017 - 2023

Associate Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2021

Associate Professor, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2021

Member, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2013 - 2020

Assistant Professor, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2015

Postdoctoral Fellow, Neuroscience, University of Colorado Health Sciences Center, Denver, CO, 2002 - 2003

Administrative Appointments/Responsibilities

Member, Credentials Committee of the Medical Staff, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - Present

Head of Radiation Oncology Strategic Initiatives, Department of Particle Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - Present

Co-Chair, Finance Committee, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - Present

Vice Chair, Radiation Safety Committee, The University of Texas MD Anderson Cancer Center, Houston, 2016 - Present

Director of Medical Student Elective Program, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2018

Other Appointments/Responsibilities

Subject Matter Expert in Carbon Ion Therapy, U.S. Food & Drug Administration (FDA) - American Society for Radiation Oncology (ASTRO), Arlington, VA, 2024 - Present

Executive Committee - Biology Representative, The Particle Therapy Cooperative Group - North America (PTCOG-NA), Rochester, MN, 2023 - Present

Member, Report Committee (RC 37) on Prescribing, Recording, and Reporting Proton Therapy, International Commission on Radiation Units and Measurements (ICRU), Bethesda, MD, 2022 - Present

Committee Chair, National Cancer Institute, NCI, 2016 - 2019

Institutional Committee Activities

Chair, Radiation Safety Committee, 2023 - Present

Member, Credentials Committee of the Medical Staff, 2020 - Present

Member, BTC Executive Committee, 2018 - Present

Vice Chair, Radiation Safety Committee, 2013 - 2023

Member, Radiation Oncology Residency Selection Committee, 2012 - Present

Honors & Awards

	Dean's List
	Phi Beta Kappa Society
	Graduated with Highest Distinction
	Dean's Scholar
	Cited for Academic Excellence
	Richard Whitehead Award for Outstanding Performance in Pharmacology by a Sophomore
	Outstanding Research Award, Department of Ophthalmology
	Individual National Research Service Award, National Institute of Mental Health
	Outstanding Graduate Student Research Award, The Retired Faculty Association
	Norman Weiner Award for Excellence in Research, Department of Pharmacology
	Franklin Gengenbach Award for Outstanding Performance in Pediatrics in the Junior Year
	Alpha Omega Alpha, University of Colorado Health Science Center
	Ravin Family Award for Outstanding Academic Performance
	Texas Radium Society Award for Outstanding Oral Presentation
	Gilbert H. Fletcher Society Resident Award
	American Society for Therapeutic Radiology and Oncology Residents/ Fellow in Radiation Oncology Research Seed Grant
	Physician Scientist Award, MD Anderson Cancer Center
	McNair Scholar, McNair Medical Institute

Professional Memberships

Particle Therapy Co-Operative Group

Member, 2010 - Present

American Radium Society

Member, 2006 - Present

Texas Radium Society

Member, 2006 - Present

American Society for Therapeutic Radiology and Oncology

Member, 2005 - Present

Radiological Society of North America

Member, 2005 - Present

Society for Neuroscience

Member, 2000 - Present

Selected Publications

Peer-Reviewed Articles

Guan F, Bronk L, Kerr M, Li Y, Braby LA, Sobieski M, Wang X, Zhang X, Stephan C, Grosshans DR, Mohan R. Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum?. Sci Rep 14(1):25181, 2024. PMID: 39448656.
Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, Bronk L, Bronk J, Wang L, Guo Y, Sahoo N, Grosshans DR, Koong AC, Zhu XR, Mohan R. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform. ArXiv None(None):None, 2024. PMID: 39314510.
Chen M, Yang D, Zhu XR, Ma L, Grosshans DR, Shao Y, Lu W. Investigation of intra-fractionated range guided adaptive proton therapy (RGAPT): (Part II) range-shift compensated on-line treatment adaptation and verification. Phys Med Biol 69(15), 2024. e-Pub 2024. PMID: 38861995.
Yang D, Zhu XR, Chen M, Ma L, Cheng X, Grosshans DR, Lu W, Shao Y. Investigation of intra-fractionated range guided adaptive proton therapy: (Part I) on-line PET imaging and range measurement. Phys Med Biol 69(15), 2024. e-Pub 2024. PMID: 38861997.
Wefel JS, Deshmukh S, Brown PD, Grosshans DR, Sulman EP, Cerhan JH, Mehta MP, Khuntia D, Shi W, Mishra MV, Suh JH, Laack NN, Chen Y, Curtis AA, Laba JM, Elsayed A, Thakrar A, Pugh SL, Bruner DW. Impact of Apolipoprotein E (APOE) Genotype on Neurocognitive Function (NCF) in Patients with Brain Metastasis (BM): An Analysis of NRG Oncology's RTOG 0614. Int J Radiat Oncol Biol Phys 119(3):846-857, 2024. e-Pub 2023. PMID: 38101486.
Milgrom SA, van Luijk P, Pino R, Ronckers CM, Kremer LC, Gidley PW, Grosshans DR, Laskar S, Okcu MF, Constine LS, Paulino AC. Salivary and Dental Complications in Childhood Cancer Survivors Treated With Radiation Therapy to the Head and Neck: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) Comprehensive Review. Int J Radiat Oncol Biol Phys 119(2):467-481, 2024. e-Pub 2021. PMID: 34074567.
Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern SL, Grosshans DR, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches. Neurooncol Pract 11(3):266-274, 2024. e-Pub 2024. PMID: 38737610.
Bronk JK, McAleer MF, McGovern SL, Lassen-Ramshad Y, Safwat A, Daw NC, Rainusso N, Mahajan A, Grosshans DR, Paulino AC. Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study. Radiother Oncol 195:110270, 2024. e-Pub 2024. PMID: 38583721.
Kim M, Maldonado JA, Pandey P, El Alam MB, Kouzy R, Christopherson K, Minsky BD, Nugyen QN, Grosshans DR, Lin LL, Mitchell MP, Klopp AH, Lee PP, Bird J, Satcher R, Lewis VO, Lin PP, Tang C, Koong AC, Moon B, Colbert LE. Single-fraction radiation retreatment for bone metastases: role of a rapid access clinic. BMJ Support Palliat Care. e-Pub 2024. PMID: 38843933.
Abu-Arja MH, Brown AL, Su JM, Okcu MF, Lindsay HB, McGovern SL, McAleer MF, Grosshans DR, Chintagumpala MM, Paulino AC. The cochlear dose and the age at radiotherapy predict severe hearing loss after passive scattering proton therapy and cisplatin in children with medulloblastoma. Neuro Oncol. e-Pub 2024. PMID: 38916058.
Sienna J, Kahalley LS, Mabbott D, Grosshans DR, Santiago AT, Paulino ADC, Merchant TE, Manzar GS, Dama H, Hodgson DC, Chintagumpala M, Okcu MF, Whitehead WE, Laperriere N, Ramaswamy V, Bartels U, Tabori U, Bennett JM, Das A, Craig T, Tsang DS. Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma. Int J Radiat Oncol Biol Phys 119(1):200-207, 2024. e-Pub 2023. PMID: 38040059.
Wang C, Rooney MK, Alvarez-Breckenridge C, Beckham TH, Chung C, De BS, Ghia AJ, Grosshans DR, Majd NK, McAleer MF, McGovern SL, North RY, Paulino AC, Perni S, Reddy JP, Rhines LD, Swanson TA, Tatsui CE, Tom MC, Yeboa DN, Li J. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era-A Population-Based Observational Study. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893133.
Grosshans DR, Thomas R, Zhang D, Cronkite C, Thomas R, Singh S, Bronk L, Morales R, Duman J. Subcellular functions of tau mediates repair response and synaptic homeostasis in injury. Res Sq, 2024. e-Pub 2024. PMID: 38464175.
Goudarzi HM, Lim G, Grosshans DR, Mohan R, Cao W. Incorporating variable RBE in IMPT optimization for ependymoma. J Appl Clin Med Phys 25(1):e14207, 2024. e-Pub 2023. PMID: 37985962.
Durante M, Bender T, Schickel E, Mayer M, Debus J, Grosshans DR, Schroeder I. Aberrant choroid plexus formation in human cerebral organoids exposed to radiation. Res Sq, 2023. e-Pub 2023. PMID: 37886443.
Rubino, F, Brahimaj, B, Hanna, EY, Su, SY, Phan, J, Grosshans, DR, DeMonte, F, Raza, SM. Does Time to Initiation of Adjuvant Radiotherapy Affect Reconstruction Outcomes after Endoscopic Resection of Skull Base Malignancies?. Journal of Neurological Surgery, Part B: Skull Base 85(5):445-457, 2023. PMID: 39228888.
Matsui JK, Allen PK, Perlow HK, Johnson JM, Paulino AC, McAleer MF, Fouladi M, Grosshans DR, Ghia AJ, Li J, Zaky WT, Chintagumpala MM, Palmer JD, McGovern SL. Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience. J Neurooncol 163(3):717-726, 2023. e-Pub 2023. PMID: 37440097.
Cao W, Li Y, Zhang X, Poenisch F, Yepes P, Sahoo N, Grosshans DR, McGovern SL, Gunn GB, Frank SJ, Zhu XR. Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma. J Appl Clin Med Phys 24(7):e13954, 2023. e-Pub 2023. PMID: 36913484.
Mash LE, Kahalley LS, Raghubar KP, Goodrich-Hunsaker NJ, Abildskov TJ, De Leon LA, MacLeod M, Stancel H, Parsons K, Biekman B, Desai NK, Grosshans DR, Paulino AC, Chu ZD, Whitehead WE, Okcu MF, Chintagumpala M, Wilde EA. Cognitive Sparing in Proton versus Photon Radiotherapy for Pediatric Brain Tumor Is Associated with White Matter Integrity: An Exploratory Study. Cancers (Basel) 15(6), 2023. e-Pub 2023. PMID: 36980730.
Hoffman LM, Jaimes C, Mankad K, Mirsky DM, Tamrazi B, Tinkle CL, Kline C, Ramasubramanian A, Malbari F, Mangum R, Lindsay H, Horne V, Daniels DJ, Keole S, Grosshans DR, Young Poussaint T, Packer R, Cavalheiro S, Bison B, Hankinson TC, Müller HL, Bartels U, Warren KE, Chintagumpala M. Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Neuro Oncol 25(2):224-233, 2023. e-Pub 2022. PMID: 36124689.
Mash LE, Kahalley LS, Okcu MF, Grosshans DR, Paulino AC, Stancel H, De Leon L, Wilde E, Desai N, Chu ZD, Whitehead WE, Chintagumpala M, Raghubar KP. Superior verbal learning and memory in pediatric brain tumor survivors treated with proton versus photon radiotherapy. Neuropsychology 37(2):204-217, 2023. e-Pub 2022. PMID: 36480379.
De B, Florez MA, Ludmir EB, Maor MH, McGovern SL, McAleer MF, Grosshans DR, Chang EL, Mahajan A, Paulino AC. Late Effects of Craniospinal Irradiation Using Electron Spinal Fields for Pediatric Cancer Patients. Int J Radiat Oncol Biol Phys 115(1):164-173, 2023. e-Pub 2022. PMID: 35716848.
Chevli N, Grosshans DR, McAleer MF, Foster JH, Harrison D, McGovern SL, Paulino AC. Renal function in abdominal neuroblastoma patients undergoing proton radiotherapy. Pediatric Blood & Cancer 70(1):e29981, 2023. e-Pub 2022. PMID: 36129239.
Guan F, Zhao L, Bronk JK, Maletic-Savatic M, Grosshans DR, Carlson DJ. Editorial: Advances in the biological effects of ionizing radiation. Front Oncol 13:1352771, 2023. e-Pub 2024. PMID: 38234403.
McGovern SL, Luo D, Johnson J, Nguyen K, Li J, McAleer MF, Yeboa D, Grosshans DR, Ghia AJ, Chung C, Bishop AJ, Song J, Thall PF, Brown PD, Mahajan A. A Prospective Study of Conventionally Fractionated Dose Constraints for Re-Irradiation of Primary Brain Tumors in Adults. Pract Radiat Oncol 13(3):231-238, 2023. e-Pub 2022. PMID: 36596356.
Gandy K, Chambers T, Raghubar KP, Fatih Okcu M, Chintagumpala M, Taylor O, Mahajan A, Kahalley LS, Chan W, Grosshans DR, Brown AL, Douglas Ris M. A Prospective Evaluation of Fatigue in Pediatric Brain Tumor Patients Treated With Radiation Therapy. J Pediatr Hematol Oncol Nurs 39(6):358-365, 2022. e-Pub 2022. PMID: 36285825.
Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans DR, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst) 35:105-112, 2022. e-Pub 2022. PMID: 36336356.
Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP. Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma. J Immunother 45(8):374-378, 2022. e-Pub 2022. PMID: 35943386.
Mallick S, V R A, Giridhar P, Upadhyay R, Kim BK, Sharma A, Elghazawy H, Elumalai T, Solipuram V, Hsieh CE, Hentz C, Solanki AA, Li J, Chan DP, Ness E, Venkatesulu BP, Grosshans DR. A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas. South Asian J Cancer 11(4):361-369, 2022. e-Pub 2022. PMID: 36756098.
McCurdy MD, Raghubar KP, Christopher K, Okcu MF, Wilde E, Desai N, Chu ZD, Gragert M, Stancel H, Warren EH, Whitehead WE, Grosshans DR, Paulino AC, Chintagumpala M, Kahalley LS. Predicting neurocognitive function in pediatric brain tumor early survivorship: The neurological predictor scale and the incremental validity of tumor size. Pediatr Blood Cancer 69(9):e29803, 2022. e-Pub 2022. PMID: 35709014.
Upadhyay R, Liao K, Grosshans DR, McGovern SL, Frances McAleer M, Zaky W, Chintagumpala MM, Mahajan A, Nana Yeboa D, Paulino AC. Quantifying the risk and dosimetric variables of symptomatic brainstem injury after proton beam radiation in pediatric brain tumors. Neuro Oncol 24(9):1571-1581, 2022. e-Pub 2022. PMID: 35157767.
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Phys Med Biol 67(15), 2022. e-Pub 2022. PMID: 35395649.
Warren EAH, Raghubar KP, Cirino PT, Child AE, Lupo PJ, Grosshans DR, Paulino AC, Okcu MF, Minard CG, Ris MD, Mahajan A, Viana A, Chintagumpala M, Kahalley LS. Cognitive predictors of social adjustment in pediatric brain tumor survivors treated with photon versus proton radiation therapy. Pediatr Blood Cancer 69(6):e29645, 2022. e-Pub 2022. PMID: 35285129.
Tang TT, Zawaski JA, Kesler S, Beamish CA, Inoue T, Perez EC, Bronk L, Poenisch F, Briere TM, Sabek OM, Grosshans DR, Waleed Gaber M. Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model. Int J Radiat Oncol Biol Phys 112(2):554-564, 2022. e-Pub 2021. PMID: 34509550.
Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM. Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma. Cancer 127(20):3865-3871, 2021. e-Pub 2021. PMID: 34254296.
Child AE, Warren EA, Grosshans DR, Paulino AC, Okcu MF, Ris MD, Mahajan A, Orobio J, Cirino PT, Minard CG, Viana AG, Bick J, Woods SP, Chintagumpala M, Kahalley LS. Long-term cognitive and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiotherapy. Pediatr Blood Cancer 68(9):e29125, 2021. e-Pub 2021. PMID: 34114294.
Bishop AJ, Livingston JA, Ning MS, Valdez ID, Wages CA, McAleer MF, Paulino AC, Grosshans DR, Woodhouse KD, Tao R, Roth ME, Gunn GB, McGovern SL. Young Adult Populations Face yet another Barrier to Care with Insurers: Limited Access to Proton Therapy. Int J Radiat Oncol Biol Phys 110(5):1496-1504, 2021. e-Pub 2021. PMID: 33677051.
Brown PD, Chung C, Liu DD, McAvoy S, Grosshans DR, Al Feghali K, Mahajan A, Li J, McGovern SL, McAleer MF, Ghia AJ, Sulman EP, Penas-Prado M, de Groot JF, Heimberger AB, Wang J, Armstrong TS, Gilbert MR, Guha-Thakurta N, Wefel JS. A Prospective Phase II Randomized Trial of Proton Radiotherapy vs. Intensity Modulated Radiotherapy for Patients with Newly Diagnosed Glioblastoma. Neuro Oncol 23(8):1337-1347, 2021. e-Pub 2021. PMID: 33647972.
Heitzer AM, Kahalley LS, Minard CG, Stafford C, Grosshans DR, Okcu MF, Raghubar KP, Gragert M, McCurdy M, Warren EH, Gomez J, Ris MD, Paulino AC, Chintagumpala M. Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas. Pediatr Blood Cancer 68(8):e29096, 2021. e-Pub 2021. PMID: 34019329.
Nantavithya C, Paulino AC, Liao K, Woodhouse KD, McGovern SL, Grosshans DR, McAleer MF, Khatua S, Chintagumpala MM, Majd N, Zaky W, Yeboa DN. Observed-to-expected incidence ratios of second malignant neoplasms after radiation therapy for medulloblastoma: A surveillance, epidemiology, and end results analysis. Cancer 127(13):2368-2375, 2021. e-Pub 2021. PMID: 33721338.
Hanania AN, Paulino AC, Ludmir EB, Shah VS, Su JM, McGovern SL, Baxter PA, McAleer MF, Grosshans DR, Okcu MF, Chintagumpala MM. Early Radiotherapy Preserves Vision in Sporadic Optic Pathway Glioma. Cancer 127(13):2358-2367, 2021. e-Pub 2021. PMID: 33739455.
Skaarup M, Lundemann MJ, Darkner S, Jørgensen M, Marner L, Mirkovic D, Grosshans DR, Peeler C, Mohan R, Vogelius IR, Appelt A. A framework for voxel-based assessment of biological effect after proton radiotherapy in pediatric brain cancer patients using multi-modal imaging. Med Phys 48(7):4110-4121, 2021. e-Pub 2021. PMID: 34021597.
Oyefiade A, Paltin I, De Luca CR, Hardy KK, Grosshans DR, Chintagumpala M, Mabbott DJ, Kahalley LS. Cognitive Risk in Survivors of Pediatric Brain Tumors. J Clin Oncol 39(16):1718-1726, 2021. e-Pub 2021. PMID: 33886348.
Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions. Med Phys 48(6):3243-3261, 2021. e-Pub 2021. PMID: 33837540.
Beamish CA, Zawaski JA, Inoue T, Sarkar P, Grosshans DR, Sabek OM, Gaber MW. NF-κB Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice. Int J Radiat Oncol Biol Phys 109(5):1508-1520, 2021. e-Pub 2020. PMID: 33307152.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 109(3):718-725, 2021. PMID: 33516439.
Paganetti H, Beltran CJ, Both S, Dong L, Flanz JB, Furutani KM, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nyström H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers JM, Shaitelman SF, Teo K, Unkelbach J, Wohlfahrt P, Lomax AJ. Roadmap: proton therapy physics and biology. Phys Med Biol 66(5), 2021. e-Pub 2020. PMID: 33227715.
Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR. Proton Therapy Reduces the Likelihood of High-Grade Radiation-Induced Lymphopenia in Glioblastoma Patients: Phase II Randomized Study of Protons vs. Photons. Neuro Oncol 23(2):284-294, 2021. e-Pub 2020. PMID: 32750703.
Al Feghali KA, Randall JW, Liu DD, Wefel JS, Brown PD, Grosshans DR, McAvoy SA, Farhat MA, Li J, McGovern SL, McAleer MF, Ghia AJ, Paulino AC, Sulman EP, Penas-Prado M, Wang J, de Groot J, Heimberger AB, Armstrong TS, Gilbert MR, Mahajan A, Guha-Thakurta N, Chung C. Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment. Neurooncol Adv 3(1):vdab073, 2021. e-Pub 2021. PMID: 34337411.
Liu SM, Brooks ED, Rubin ML, Consortium MD, Grosshans DR, Frank SJ, McAleer MF, McGovern SL, Paulino AC, Woodhouse KD. Referral Patterns and Treatment Delays in Medulloblastoma: A Large Academic Proton Center Experience. Int J Part Ther 7(3):1-10, 2021. e-Pub 2020. PMID: 33604411.
Spiotto MT, McGovern SL, Gunn GB, Grosshans DR, McAleer MF, Frank SJ, Paulino AC. Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers. Int J Part Ther 8(1):155-167, 2021. e-Pub 2021. PMID: 34285943.
Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers (Basel) 12(12), 2020. e-Pub 2020. PMID: 33291477.
Abolfath R, Grosshans DR, Mohan R. Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation. Med Phys 47(12):6551-6561, 2020. e-Pub 2020. PMID: 33089504.
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Author Correction: Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):19101, 2020. e-Pub 2020. PMID: 33127998.
Lin TA, Ludmir EB, Liao KP, McAleer MF, Bishop AJ, Grosshans DR, McGovern S, Woodhouse KD, Paulino AC, Yeboa DN. Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing. Pediatr Blood Cancer:e28685. e-Pub 2020. PMID: 32881378.
Vassiliev ON, Peterson CB, Grosshans DR, Mohan R. A simple model for calculating relative biological effectiveness of X-rays and gamma radiation in cell survival. Br J Radiol 93(1112):20190949, 2020. e-Pub 2020. PMID: 32464080.
Nantavithya C, Paulino AC, Liao K, McGovern SL, Grosshans DR, McAleer MF, Woodhouse KD, Khatua S, Chintagumpala MM, Majd NK, Yeboa DN. Development of second primary tumors and outcomes in medulloblastoma by treatment modality: A Surveillance, Epidemiology, and End Results analysis. Pediatr Blood Cancer 67(8):e28373, 2020. e-Pub 2020. PMID: 32453481.
Kahalley LS, Peterson R, Ris MD, Janzen L, Okcu MF, Grosshans DR, Ramaswamy V, Paulino AC, Hodgson D, Mahajan A, Tsang DS, Laperriere N, Whitehead WE, Dauser RC, Taylor MD, Bouffet E, Chintagumpala M, Mabbott D. Reply to S.A. Milgrom et al. J Clin Oncol 38(19):2212-2213, 2020. e-Pub 2020. PMID: 32374644.
Abolfath R, Helo Y, Carlson DJ, Stewart R, Grosshans DR, Mohan R. A New Approach to Modeling the Microdosimetry of Proton Therapy Beams. Med Phys 47(7):3184-3190, 2020. e-Pub 2020. PMID: 32249429.
Noticewala SS, Ludmir EB, Bishop AJ, Chung C, Ghia AJ, Grosshans DR, McGovern S, Paulino AC, Wang C, Woodhouse KD, Yeboa DN, Prabhu SS, Weathers SP, Das P, Koong AC, McAleer MF, Li J. Radiation for Glioblastoma in the Era of Coronavirus Disease 2019 (COVID-19): Patient Selection and Hypofractionation to Maximize Benefit and Minimize Risk. Adv Radiat Oncol 5(4):743-745, 2020. e-Pub 2020. PMID: 32775785.
Bai X, Lim G, Grosshans DR, Mohan R, Cao W. A biological effect-guided optimization approach using beam distal-edge avoidance for intensity-modulated proton therapy. Med Phys. e-Pub 2020. PMID: 32557747.
Zhang D, Zhou W, Lam TT, Li V, Duman JG, Dougherty PM, Grosshans DR. Cranial irradiation induces axon initial segment dysfunction and neuronal injury in the prefrontal cortex and impairs hippocampal coupling. Neurooncol Adv. e-Pub 2020. PMID: 32642710.
Raghubar KP, Rothhaar MC, Yeates KO, Mahone EM, Grosshans DR, Scheurer ME, Ris MD. Premorbid functioning as a predictor of outcome in pediatric brain tumor: An initial examination of the normalcy assumption. Pediatr Blood Cancer 67(4):e28135, 2020. e-Pub 2019. PMID: 31886612.
Brown PD, Gondi V, Pugh S, Tome WA, Wefel JS, Armstrong TS, Bovi JA, Robinson C, Konski A, Khuntia D, Grosshans DR, Benzinger TLS, Bruner D, Gilbert MR, Roberge D, Kundapur V, Devisetty K, Shah S, Usuki K, Anderson BM, Stea B, Yoon H, Li J, Laack NN, Kruser TJ, Chmura SJ, Shi W, Deshmukh S, Mehta MP, Kachnic LA, Oncology FN. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. J Clin Oncol 38(10):1019-1029, 2020. e-Pub 2020. PMID: 32058845.
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):3199, 2020. e-Pub 2020. PMID: 32081928.
Roth AK, Ris MD, Orobio J, Xue J, Mahajan A, Paulino AC, Grosshans DR, Okcu MF, Chintagumpala M, Kahalley LS. Cognitive mediators of adaptive functioning outcomes in survivors of pediatric brain tumors treated with proton radiotherapy. Pediatr Blood Cancer 67(2):e28064, 2020. e-Pub 2019. PMID: 31736188.
Kahalley LS, Peterson R, Ris MD, Janzen L, Okcu MF, Grosshans DR, Ramaswamy V, Paulino AC, Hodgson D, Mahajan A, Tsang DS, Laperriere N, Whitehead WE, Dauser RC, Taylor MD, Conklin HM, Chintagumpala M, Bouffet E, Mabbott D. Superior Intellectual Outcomes After Proton Radiotherapy Compared With Photon Radiotherapy for Pediatric Medulloblastoma. J Clin Oncol 38(5):454-461, 2020. e-Pub 2019. PMID: 31774710.
Evans LT, DeMonte F, Grosshans DR, Ghia AJ, Habib A, Raza SM. Salvage Therapy for Local Progression following Definitive Therapy for Skull Base Chordomas: Is There a Role of Stereotactic Radiosurgery?. J Neurol Surg B Skull Base 81(1):97-106, 2020. e-Pub 2019. PMID: 32021756.
Abolfath R, Peeler C, Mirkovic D, Mohan R, Grosshans DR. A DNA damage multi-scale model for NTCP in proton and hadron therapy. Med Phys 47(4). e-Pub 2020. PMID: 31955444.
Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Non-homologous end joining is more important than proton linear energy transfer in dictating cell death. Int J Radiat Oncol Biol Phys 105(5):1119-1125, 2019. e-Pub 2019. PMID: 31425731.
Wu RY, Liu AY, Yang J, Williamson TD, Wisdom PG, Bronk L, Gao S, Grosshans DR, Fuller DC, Gunn GB, Zhu XR, Frank SJ. Evaluation of the accuracy of deformable image registration on MRI with a physical phantom. J Appl Clin Med Phys. e-Pub 2019. PMID: 31808307.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma. Pediatr Blood Cancer 66(11):e27952, 2019. e-Pub 2019. PMID: 31397065.
Vassiliev ON, Peterson CB, Cao W, Grosshans DR, Mohan R. Systematic microdosimetric data for protons of therapeutic energies calculated with Geant4-DNA. Phys Med Biol 64(21), 2019. e-Pub 2019. PMID: 31553958.
Raghubar KP, Orobio J, Ris MD, Heitzer AM, Roth A, Brown AL, Okcu MF, Chintagumpala M, Grosshans DR, Paulino AC, Mahajan A, Kahalley LS. Adaptive functioning in pediatric brain tumor survivors: An examination of ethnicity and socioeconomic status. Pediatr Blood Cancer 66(9):e27800, 2019. e-Pub 2019. PMID: 31134755.
Bagley AF, Grosshans DR, Philip NV, Foster J, McAleer MF, McGovern SL, Lassen-Ramshad Y, Mahajan A, Paulino AC. Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma. Pediatr Blood Cancer 66(8):e27786, 2019. e-Pub 2019. PMID: 31050179.
Ludmir EB, Mahajan A, Ahern V, Ajithkumar T, Alapetite C, Bernier-Chastagner V, Bindra RS, Bishop AJ, Bolle S, Brown PD, Carrie C, Chalmers AJ, Chang EL, Chung C, Dieckmann K, Esiashvili N, Gandola L, Ghia AJ, Gondi V, Grosshans DR, Harrabi SB, Horan G, Indelicato DJ, Jalali R, Janssens GO, Krause M, Laack NN, Laperriere N, Laprie A, Li J, Marcus KJ, McGovern SL, Merchant TE, Merrell KW, Padovani L, Parkes J, Paulino AC, Schwarz R, Shih HA, Souhami L, Sulman EP, Taylor RE, Thorp N, Timmermann B, Wheeler G, Wolden SL, Woodhouse KD, Yeboa DN, Yock TI, Kortmann RD, McAleer MF. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology. Nat Rev Clin Oncol 16(8):521-522, 2019. e-Pub 2019. PMID: 31150024.
Darne CD, Alsanea F, Robertson D, Guan F, Pan T, Grosshans DR, Beddar S. A proton imaging system using a volumetric liquid scintillator: a preliminary study. Biomedical Physics & Engineering Express 5(4), 2019. e-Pub 2019. PMID: 32194988.
Ning MS, Gomez DR, Shah AK, Kim CR, Palmer MB, Thaker NG, Grosshans DR, Liao Z, Chapman BV, Brooks ED, Tang C, Rosenthal DI, Garden AS, Frank SJ, Gunn GB. The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care. Int J Radiat Oncol Biol Phys 104(4):724-733, 2019. e-Pub 2018. PMID: 30557675.
Darne CD, Alsanea F, Robertson D, Guan F, Pan T, Grosshans DR, Beddar S. A novel proton imaging system using a large-volume liquid scintillator: a preliminary study. Medical Physics, 2019. PMID: 32194988.
Tang TT, Zawaski JA, Kesler SR, Beamish CA, Reddick WE, Glass JO, Carney DH, Sabek OM, Grosshans DR, Gaber MW. A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury. Neurooncol Adv. e-Pub 2019. PMID: 31608330.
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness. Int J Radiat Oncol Biol Phys 104(2):316-324, 2019. e-Pub 2019. PMID: 30731186.
Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC, Grosshans DR, Khatua S, Ketonen L, Fontanilla H, McGovern SL. In Reply to Krishnatry and Manjali. Int J Radiat Oncol Biol Phys 104(2):468-469, 2019. PMID: 31047634.
Kahalley LS, Ris MD, Mahajan A, Okcu MF, Chintagumpala M, Paulino AC, Whitehead WE, Minard CG, Stancel HH, Orobio J, Xue JJ, Warren EA, Grosshans DR. Prospective, Longitudinal Comparison of Neurocognitive Change in Pediatric Brain Tumor Patients Treated with Proton Radiotherapy versus Surgery Only. Neuro Oncol 21(6):809-818, 2019. e-Pub 2019. PMID: 30753584.
Ludmir EB, Mahajan A, Paulino AC, Jones JY, Ketonen LM, Su JM, Grosshans DR, McAleer MF, McGovern SL, Lassen-Ramshad YA, Adesina AM, Dauser RC, Weinberg JS, Chintagumpala MM. Increased Risk of Pseudoprogression among Pediatric Low-Grade Glioma Patients Treated with Proton versus Photon Radiotherapy. Neuro Oncol 21(5):686-695, 2019. e-Pub 2019. PMID: 30753704.
Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC, Grosshans DR, Khatua S, Ketonen L, Fontanilla H, McGovern SL. A Phase I/II Trial of Reirradiation for Diffuse Intrinsic Pontine Glioma. Int J Radiat Oncol Biol Phys 104(1):144-148, 2019. e-Pub 2019. PMID: 30610915.
Lin TA, Ludmir EB, Liao KP, McAleer MF, Grosshans DR, McGovern SL, Bishop AJ, Woodhouse KD, Paulino AC, Yeboa DN. Timing of Local Therapy Impacts Survival in Ewing Sarcoma. Int J Radiat Oncol Biol Phys 104(1):127-136, 2019. e-Pub 2018. PMID: 30593906.
Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Patterns of failure following proton beam therapy for head and neck rhabdomyosarcoma. Radiother Oncol 134:143-150, 2019. e-Pub 2019. PMID: 31005208.
Buszek SM, Ikner S, Wiedermann L, Wang J, McAleer MF, Grosshans DR, de la Cruz Paulino A, McGovern SL, Chung C. Safety and Feasibility of Magnetic Resonance Imaging Simulation for Radiation Treatment Planning in Pediatric Patients: A Single Institution Experience. Advances in Radiation Oncology 4(2):362-366, 2019. e-Pub 2018. PMID: 31011682.
Abolfath R, Helo Y, Bronk L, Carabe A, Grosshans DR, Mohan R. Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control. The European Physical Journal D 73(64), 2019. PMID: None.
Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans DR, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys 46(3):e53-e78, 2019. e-Pub 2019. PMID: 30661238.
Yeboa DN, Yu JB, Liao E, Huse J, Penas-Prado M, Kann BH, Sulman E, Grosshans DR, Contessa J. Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas. Clin Transl Radiat Oncol 15:46-52, 2019. e-Pub 2018. PMID: 30656222.
Jaramillo S, Grosshans DR, Philip N, Varan A, Akyüz C, McAleer MF, Mahajan A, McGovern SL. Radiation for ETMR: Literature review and case series of patients treated with proton therapy. Clin Transl Radiat Oncol 15:31-37, 2019. e-Pub 2018. PMID: 30582019.
Kohno R, Cao W, Yepes P, Bai X, Poenisch F, Grosshans DR, Akimoto T, Mohan R. Biological Dose Comparison between a Fixed RBE and a variable RBE in SFO and MFO IMPT with Various Multi-Beams for Brain Cancer. International Journal of Medical Physics,Clinical Engineering and Radiation Oncology 8(1):32-45, 2019. PMID: None.
Cao W, Khabazian A, Yepes P, Lim G, Poenisch F, Grosshans DR, Mohan R. Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'. Phys Med Biol 64(5):058002, 2019. e-Pub 2019. PMID: 30811349.
Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR. Report of a National Cancer Institute Special Panel: Characterization of the Physical Parameters of Particle Beams for Biological Research. Medical Physics 46(2):e37-e52, 2019. e-Pub 2018. PMID: 30506898.
Bai X, Lim G, Grosshans DR, Mohan R, Cao W. Robust optimization to reduce the impact of biological effect variation from physical uncertainties in intensity-modulated proton therapy. Phys Med Biol 64(2):1361-1365, 2019. PMID: 30523932.
Guan F, Geng C, Carlson DJ, Ma DH, Bronk L, Gates D, Wang X, Kry SF, Grosshans DR, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Phys Med Biol 64(1):015008, 2018. e-Pub 2018. PMID: 30523805.
Yepes P, Adair A, Frank SJ, Grosshans DR, Liao Z, Liu A, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy. Adv Radiat Oncol 4(1):156-167, 2018. PMID: 30706024.
Yepes P, Adair A, Frank SJ, Grosshans DR, Liao Z, Liu A, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy. Adv Radiat Oncol 4(1):156-167, 2018. PMID: None.
Vatner RE, Niemierko A, Misra M, Weyman EA, Goebel CP, Ebb DH, Jones RM, Huang MS, Mahajan A, Grosshans DR, Paulino AC, Stanley T, MacDonald SM, Tarbell NJ, Yock TI. Endocrine Deficiency as a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors. J Clin Oncol 36(28):2854-2862, 2018. e-Pub 2018. PMID: 30118397.
Stoker J, Vora S, Patel A, Grosshans DR, Brown PD, Vern-Gross T, Bues M, Daniels T, Allred B, Uejo A, Kosiorek H, Bruso M, Keole S. Advantages of intensity modulated proton therapy during hippocampal. Physics and Imaging in Radiation Oncology 8(2018):28-32, 2018. PMID: None.
Grosshans DR, Duman JG, Gaber MW, Sawakuchi G. Particle Radiation Induced Neurotoxicity in the Central Nervous System. International Journal of Particle Therapy, 2018. PMID: None.
Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans DR, Mohan R. RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies. International Journal of Particle Therapy 5(1):160-171, 2018. PMID: 30338268.
Raghubar KP, Lamba M, Cecil KM, Yeates KO, Mahone EM, Limke C, Grosshans DR, Beckwith TJ, Ris MD. Dose-volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study. Pediatr Blood Cancer 65(9):e27245, 2018. e-Pub 2018. PMID: 29856521.
Raza SM, Bell D, Freeman JL, Grosshans DR, Fuller GN, DeMonte F. Multimodality Management of Recurrent Skull Base Chordomas: Factors Impacting Tumor Control and Disease-Specific Survival. Oper Neurosurg (Hagerstown) 15(2):131-143, 2018. e-Pub 2017. PMID: 29040778.
Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Wang Q, Duman JG, Dougherty PM, Grosshans DR. Radiation induces age-dependent deficits in cortical synaptic plasticity. Neuro Oncol 20(9):1207-1214, 2018. e-Pub 2018. PMID: 29660023.
Grosshans DR, Brown PD. Chemotherapy Plus Proton or Photon Radiation on a Trial. Int J Radiat Oncol Biol Phys 101(3):518-519, 2018. PMID: 29893270.
Paulino AC, Mahajan A, Ye R, Grosshans DR, Fatih Okcu M, Su J, McAleer MF, McGovern S, Mangona VA, Chintagumpala M. Ototoxicity and cochlear sparing in children with medulloblastoma: Proton vs. photon radiotherapy. Radiother Oncol 128(1):128-132, 2018. e-Pub 2018. PMID: 29373195.
Ludmir EB, Paulino AC, Grosshans DR, McAleer MF, McGovern SL, Huh WW, Okcu MF, Harrell LM, Mahajan A. Regional Nodal Control for Head and Neck Alveolar Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 101(1):169-176, 2018. e-Pub 2018. PMID: 29477293.
Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Paveškovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol 20(5):655-665, 2018. e-Pub 2017. PMID: 29112734.
Wilke C, Grosshans DR, Duman J, Brown P, Li J. Radiation-induced cognitive toxicity: Pathophysiology and interventions to reduce toxicity in adults. Neuro Oncol 20(5):597-607, 2018. e-Pub 2017. PMID: 29045710.
Vassiliev ON, Kry SF, Grosshans DR, Mohan R. Average stopping powers for electron and photon sources for radiobiological modeling and microdosimetric applications. Phys Med Biol 63(5):055007, 2018. e-Pub 2018. PMID: 29411712.
Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code" [Med. Phys. 42 (11), page range 6234-6247(2015)]. Med Phys 45(3):1302, 2018. e-Pub 2018. PMID: 29527697.
Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness" [Med. Phys. 43 (2), page range 761-776(2016)]. Med Phys 45(3):1301, 2018. e-Pub 2018. PMID: 29527699.
Yepes P, Adair A, Grosshans DR, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Comparison of Monte Carlo and analytical dose computations for intensity modulated proton therapy. Phys Med Biol 63(4):045003, 2018. e-Pub 2018. PMID: 29339570.
Bronk JK, Guha-Thakurta N, Allen PK, Mahajan A, Grosshans DR, McGovern SL. Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma. Clin Transl Radiat Oncol 9:30-34, 2018. PMID: 29594248.
Cao W, Khabazian A, Yepes PP, Lim GJ, Poenisch F, Grosshans DR, Mohan R. Linear energy transfer incorporated intensity modulated proton therapy optimization. Phys Med Biol 63(1), 2017. e-Pub 2017. PMID: 29131808.
Wang X, Li Y, Zhang X, Li H, Miyazaki K, Fujimoto R, Akiyama H, Gillin MT, Poenisch F, Sahoo N, Grosshans DR, Gunn B, Frank SJ, Wang P, Lang J, Hou Q, Zhu XR. Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery. Cancers (Basel) 9(12), 2017. e-Pub 2017. PMID: 29236051.
Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans DR, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Med Phys 44(11):6061-6073, 2017. e-Pub 2017. PMID: 28880368.
Kohno R, Cao W, Yepes P, Bai X, Poenisch F, Grosshans DR, Akimoto T, Mohan R. Dose Comparison between Eclipse Dose Calculation and Fast Dose Calculator in Single- and Multi-Field Optimization Intensity-Modulated Proton Therapy Plans with Various Multi-Beams for Brain Cancer. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology. e-Pub 2017. PMID: None.
Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncol 56(11):1-7, 2017. e-Pub 2017. PMID: 28826292.
Vassiliev ON, Grosshans DR, Mohan R. A new formalism for modelling parameters α and β of the linear quadratic model of cell survival for hadron therapy. Phys Med Biol 62(20):8041-8059, 2017. e-Pub 2017. PMID: 28832343.
Raza SM, Gidley PW, Meis JM, Grosshans DR, Bell D, DeMonte F. Multimodality Treatment of Skull Base Chondrosarcomas: The Role of Histology Specific Treatment Protocols. Neurosurgery 81(3):520-530, 2017. PMID: 28368506.
Abolfath R, Peeler CR, Newpower M, Bronk L, Grosshans DR, Mohan R. A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data. Sci Rep 7(1):8340, 2017. e-Pub 2017. PMID: 28827691.
Antonini TN, Ris MD, Grosshans DR, Mahajan A, Okcu MF, Chintagumpala M, Paulino A, Child AE, Orobio J, Stancel HH, Kahalley LS. Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy. Radiother Oncol 124(1):89-97, 2017. e-Pub 2017. PMID: 28655455.
Grosshans DR, Mohan R, Gondi V, Shih HA, Mahajan A, Brown PD. The role of image-guided intensity modulated proton therapy in glioma. Neuro Oncol 19(suppl_2):ii30-ii37, 2017. PMID: 28380636.
Hou P, Zhu KH, Park PC, Li H, Mahajan A, Grosshans DR. Proton Therapy for Juvenile Pilocytic Astrocytoma: Quantifying Treatment Responses by Magnetic Resonance Diffusion Tensor Imaging. International Journal of Particle Therapy 3(3):414-420, 2017. PMID: None.
Chun SG, Solberg TD, Grosshans DR, Nguyen QN, Simone CB, Mohan R, Liao Z, Hahn SM, Herman JM, Frank SJ. The Potential of Heavy-Ion Therapy to Improve Outcomes for Locally Advanced Non-Small Cell Lung Cancer. Front Oncol 7:201, 2017. e-Pub 2017. PMID: 28929085.
Peeler CR, Mirkovic D, Titt U, Blanchard P, Gunther JR, Mahajan A, Mohan R, Grosshans DR. Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma. Radiother Oncol 121(3):395-401, 2016. e-Pub 2016. PMID: 27863964.
Wang X, Poenisch F, Sahoo N, Zhu RX, Lii M, Gillin MT, Li J, Grosshans DR. Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy. J Appl Clin Med Phys 17(5):366-376, 2016. e-Pub 2016. PMID: 27685136.
Jiang S, Wang J, Li H, Liao L, Li Y, Wang X, Yang Y, Zhu RX, Sahoo N, Gillin MT, Hojo Y, Sun J, Chang JY, Liao Z, Grosshans DR, Frank SJ, Zhang X. Novel Hybrid Scattering- and Scanning-Beam Proton Therapy Approach. International Journal of Particle Therapy 3(1):37-50, 2016. PMID: None.
Tucker SL, Liu A, Gomez D, Tang LL, Allen P, Yang J, Liao Z, Grosshans DR. Impact of heart and lung dose on early survival in patients with non-small cell lung cancer treated with chemoradiation. Radiother Oncol 119(3):495-500, 2016. e-Pub 2016. PMID: 27189523.
Owusu-Agyemang P, Popovich SM, Zavala AM, Grosshans DR, Van Meter A, Williams UU, Holmes AA, Arunkumar R, Rebello E, McAleer MF, Porche V, Mahajan A. A multi-institutional pilot survey of anesthesia practices during proton radiation therapy. Pract Radiat Oncol 6(3):155-9, 2016. e-Pub 2015. PMID: 26725965.
Kahalley LS, Ris MD, Grosshans DR, Okcu MF, Paulino AC, Chintagumpala M, Moore BD, Guffey D, Minard CG, Stancel HH, Mahajan A. Comparing Intelligence Quotient Change After Treatment With Proton Versus Photon Radiation Therapy for Pediatric Brain Tumors. J Clin Oncol 34(10):1043-9, 2016. e-Pub 2016. PMID: 26811522.
Agarwal A, Thaker NG, Tawk B, Allen PK, Grosshans DR, Herzog CE, Gombos DS, Mahajan A. The Evolution of Radiation Therapy for Retinoblastoma: The MD Anderson Cancer Center Experience. International Journal of Particle Therapy 4(4):490-498, 2016. PMID: None.
Grosshans DR. Proton therapy for paediatric medulloblastoma. Lancet Oncol 17(3):258-9, 2016. e-Pub 2016. PMID: 26830376.
Munck Af Rosenschold P, Engelholm SA, Brodin PN, Jørgensen M, Grosshans DR, Zhu RX, Palmer M, Crawford CN, Mahajan A. A Retrospective Evaluation of the Benefit of Referring Pediatric Cancer Patients to an External Proton Therapy Center. Pediatr Blood Cancer 63(2):262-269, 2016. e-Pub 2015. PMID: 26397177.
Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of ³He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761-76, 2016. PMID: 26843239.
Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans DR, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 42(11):6234, 2015. PMID: 26520716.
Grant SR, Grosshans DR, Bilton SD, Garcia JA, Amin M, Chambers MS, McGovern SL, McAleer MF, Morrison WH, Huh WW, Kupferman ME, Mahajan A. Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics. Radiother Oncol 116(2):309-15, 2015. e-Pub 2015. PMID: 26232128.
Holliday EB, Mitra HS, Somerson JS, Rhines LD, Mahajan A, Brown PD, Grosshans DR. Post-operative proton therapy for chordomas and chondrosarcomas of the spine: Adjuvant vs. salvage radiation therapy. Spine (Phila Pa 1976) 40(8):544-9, 2015. e-Pub 2015. PMID: 25627289.
Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015. PMID: 25984967.
McGovern SL, Okcu MF, Munsell MF, Kumbalasseriyil N, Grosshans DR, McAleer MF, Chintagumpala M, Khatua S, Mahajan A. Outcomes and Acute Toxicities of Proton Therapy for Pediatric Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System. Int J Radiat Oncol Biol Phys 90(5):1143-52, 2014. e-Pub 2014. PMID: 25311260.
Ladra MM, Szymonifka JD, Mahajan A, Friedmann AM, Yong Yeap B, Goebel CP, MacDonald SM, Grosshans DR, Rodriguez-Galindo C, Marcus KJ, Tarbell NJ, Yock TI. Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma. J Clin Oncol 32(33):3762-70, 2014. e-Pub 2014. PMID: 25332253.
Stoker JB, Grant J, Zhu XR, Pidikiti R, Mahajan A, Grosshans DR. Intensity modulated proton therapy for craniospinal irradiation: organ-at-risk exposure and a low-gradient junctioning technique. Int J Radiat Oncol Biol Phys 90(3):637-44, 2014. e-Pub 2014. PMID: 25194667.
Grosshans DR, Zhu XR, Melancon A, Allen PK, Poenisch F, Palmer M, McAleer MF, McGovern SL, Gillin M, DeMonte F, Chang EL, Brown PD, Mahajan A. Spot Scanning Proton Therapy for Malignancies of the Base of Skull: Treatment Planning, Acute Toxicities, and Preliminary Clinical Outcomes. Int J Radiat Oncol Biol Phys 90(3):540-6, 2014. e-Pub 2014. PMID: 25304948.
Gomez DR, Yusuf SW, Munsell MF, Welsh JW, Liao Z, Lin SH, Pan HY, Chang JY, Komaki R, Cox JD, McAleer MF, Grosshans DR. Prospective exploratory analysis of cardiac biomarkers and electrocardiogram abnormalities in patients receiving thoracic radiation therapy with high-dose heart exposure. J Thorac Oncol 9(10):1554-60, 2014. PMID: 25521400.
Bishop AJ, Greenfield B, Mahajan A, Paulino AC, Okcu MF, Allen PK, Chintagumpala M, Kahalley LS, McAleer MF, McGovern SL, Whitehead WE, Grosshans DR. Proton Beam Therapy Versus Conformal Photon Radiation Therapy for Childhood Craniopharyngioma: Multi-institutional Analysis of Outcomes, Cyst Dynamics, and Toxicity. Int J Radiat Oncol Biol Phys 90(2):354-61, 2014. e-Pub 2014. PMID: 25052561.
Ladra MM, Samantha K Edgington SK, Szymonifka J, Mahajan A, Khan F, Moteabbed M, Friedmann AM, MacDonald SM, Grosshans DR, Tarbell NJ, Yock TI. A Dosimetric Comparison of Proton Radiotherapy and IMRT in Pediatric RMS Patients Enrolled on a Phase II Proton Study. Radiotherapy Oncology 113(1):77-83, 2014. PMID: 25443861.
Zhu, XR, Poenisch F, Wu RY, Taylor MB, Sahoo N, Zhang X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Palmer MB, Amin MV, Gillin MT, Mahajan A, Grosshans DR. A Single-Field Integrated Boost Technique for Spot Scanning Proton Therapy. Radiation Oncology, 2014. PMID: 25212571.
LeRoux LG, Bredow S, Grosshans DR, Schellingerhout D. Molecular Imaging Detects Impairment in the Retrograde Axonal Transport Mechanism After Radiation-Induced Spinal Cord Injury. Mol Imaging Biol 16(4):504-10, 2014. e-Pub 2014. PMID: 24395625.
Shao Y, Sun X, Lou K, Zhu XR, Mirkovic D, Poenisch F, Grosshans DR. In-beam PET imaging for on-line adaptive proton therapy: An initial phantom study. Phys Med Biol 59(13):3373-88, 2014. e-Pub 2014. PMID: 24874943.
Tucker SL, Liao Z, Dinh J, Bian SX, Mohan R, Martel MK, Grosshans DR. Is there an impact of heart exposure on the incidence of radiation pneumonitis? Analysis of data from a large clinical cohort. Acta Oncol 53(5):590-6, 2014. e-Pub 2013. PMID: 23992110.
Owusu-Agyemang P, Grosshans DR, Arunkumar R, Rebello E, Popovich S, Zavala A, Williams C, Ruiz J, Hernandez M, Mahajan A, Porche V. Non-invasive anesthesia for children undergoing proton radiation therapy. Radiother Oncol 111(1):30-4, 2014. e-Pub 2014. PMID: 24560754.
Barney CL, Brown AP, Grosshans DR, McAleer MF, de Groot JF, Puduvalli V, Tucker SL, Crawford CN, Gilbert MR, Brown PD, Mahajan A. Technique, outcomes, and acute toxicities in adults treated with proton beam craniospinal irradiation. Neuro Oncol 16(2):303-9, 2014. e-Pub 2013. PMID: 24311638.
Mackin D, Zhu XR, Poenisch F, Heng L, Sahoo N, Kerr M, Holmes C, Li Y, Liii M, Wu R, Suzuki K, Gillin MT, Frank SJ, Grosshans DR, Zhang X. Spot-Scanning Proton Therapy Patient-Specific Quality Assurance: Results from 309 Treatment Plans. International Journal of Particle Therapy, 2014. PMID: None.
Liu W, Mohan R, Park P, Liu Z, Li H, Li X, Li Y, Wu R, Sahoo N, Dong L, Zhu XR, Grosshans DR. Dosimetric benefits of robust treatment planning for intensity modulated proton therapy for base-of-skull cancers. Pract Radiat Oncol 4(6):384-91, 2014. e-Pub 2014. PMID: 25407859.
Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, Wu RY, Li X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Gillin MT, Mahajan A, Grosshans DR. A single-field integrated boost treatment planning technique for spot scanning proton therapy. Radiat Oncol 9:202, 2014. e-Pub 2014. PMID: 25212571.
Brown AP, Barney CL, Grosshans DR, McAleer MF, de Groot JF, Puduvalli VK, Tucker SL, Crawford CN, Khan M, Khatua S, Gilbert MR, Brown PD, Mahajan A. Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma. Int J Radiat Oncol Biol Phys 86(2):277-84, 2013. e-Pub 2013. PMID: 23433794.
Bian SX, McAleer MF, Vats TS, Mahajan A, Grosshans DR. Pilocytic astrocytoma with leptomeningeal dissemination. Childs Nerv Syst 29(3):441-50, 2013. e-Pub 2012. PMID: 23207974.
Dinh J, Stoker J, Georges RH, Sahoo N, Zhu XR, Rath S, Mahajan A, Grosshans DR. Comparison of proton therapy techniques for treatment of the whole brain as a component of craniospinal radiation. Radiat Oncol 8:289, 2013. e-Pub 2013. PMID: 24344645.
Amsbaugh MJ, Grosshans DR, McAleer MF, Zhu R, Wages C, Crawford CN, Palmer M, De Gracia B, Woo S, Mahajan A. Proton Therapy for Spinal Ependymomas: Planning, Acute Toxicities and Preliminary Outcomes. Int J Radiat Oncol Biol Phys 83(5):1419-24, 2012. e-Pub 2012. PMID: 22245209.
Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, Anderson P, Green HL, Mahajan A. Whole Abdominopelvic Intensity-Modulated Radiation Therapy for Desmoplastic Small Round Cell Tumor after Surgery. Int J Radiat Oncol Biol Phys 83(1):317-26, 2012. e-Pub 2011. PMID: 22104361.
Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, Rhines LD, Chang EL. Vertebral Compression Fracture Risk After Stereotactic Body Radiotherapy for Spinal Metastases. J Neurosurg Spine 16(4):379-86, 2012. e-Pub 2012. PMID: 22225488.
Boehling NS, Grosshans DR, Bluett JB, Palmer MT, Song X, Amos RA, Sahoo N, Meyer JJ, Mahajan A, Woo SY. Dosimetric Comparison of Three-Dimensional Conformal Proton Radiotherapy, Intensity-Modulated Proton Therapy, and Intensity-Modulated Radiotherapy for Treatment of Pediatric Craniopharyngiomas. Int J Radiat Oncol Biol Phys 82(2):643-52, 2012. e-Pub 2011. PMID: 21277111.
Amsbaugh MJ, Zhu XR, Palmer M, Poenisch F, Mahajan A, Grosshans DR. Spot Scanning Proton Therapy for Craniopharyngioma. Practical Radiation Oncology 2(4):314-318, 2012. PMID: 24674170.
Grosshans DR, Boehling N, Palmer M, Spicer C, Erice R, Cox JD, Komaki R, Chang J. Improving Cardiac Dosimetry: Alternative Beam Arrangements for IMRT Planning in Patients with Carcinoma of the Distal Esophagus. Practical Radiation Oncology 2(1):41-45. e-Pub 2012. PMID: 24674035.
Sharp H, Grosshans DR, Kadia T, Dabaja BS. Cutaneous graft-versus-host disease after proton-based craniospinal irradiation for recurrent Philadelphia-positive acute lymphoblastic leukemia. BMJ Case Rep 2012, 2012. e-Pub 2012. PMID: 22787181.
Wu PH, Coultrap S, Pinnix C, Davies KD, Tailor R, Ang KK, Browning MD, Grosshans DR. Radiation induces acute alterations in neuronal function. PLoS One 7(5):e37677, 2012. e-Pub 2012. PMID: 22662188.
Moeller BJ, Chintagumpala M, Philip JJ, Grosshans DR, McAleer MF, Woo SY, Gidley PW, Vats TS, Mahajan A. Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. Radiat Oncol 2(6):1-7, 2011. e-Pub 2011. PMID: 21635776.
Grosshans DR, Meyers CA, Allen PK, Davenport SD, Komaki R. Neurocognitive function in patients with small cell lung cancer: effect of prophylactic cranial irradiation. Cancer 112(3):589-95, 2008. PMID: 18098269.
Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol 98(5):2818-26, 2007. e-Pub 2007. PMID: 17728388.
Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD. Tyrosine dephosphorylation and ethanol inhibition of N-Methyl-D-aspartate receptor function. J Biol Chem 278(13):11020-5, 2003. e-Pub 2003. PMID: 12536146.
Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE 2002(137):PL8, 2002. PMID: 12072555.
Clayton DA, Grosshans DR, Browning MD. Aging and surface expression of hippocampal NMDA receptors. J Biol Chem 277(17):14367-9, 2002. e-Pub 2002. PMID: 11891215.
Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5(1):27-33, 2002. PMID: 11740502.
Grosshans DR, Browning MD. Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor. J Neurochem 76(3):737-44, 2001. PMID: 11158244.
Oh JJ, Grosshans DR, Wong SG, Slamon DJ. Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. Nucleic Acids Res 27(20):4008-17, 1999. PMID: 10497265.
Péterfy M, Gyuris T, Grosshans DR, Cuaresma CC, Takács L. Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. Genomics 47(2):200-6, 1998. PMID: 9479492.
Chang M, McNinch J, Elias C, Manthey CL, Grosshans DR, Meng T, Boone T, Andrew DP. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. J Biol Chem 272(40):25229-37, 1997. PMID: 9312138.
Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans DR, Ramos L, Reese DM, Slamon DJ, Calzone FJ. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. Oncogene 14(1):1-16, 1997. PMID: 9010228.
Fada G, Titt U, Peeler C, Bronk L, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans DR, Mohan R. Quantification of an Appropriate LET for Use in Predicting Biological Effects in Proton Therapy: Analysis of the Averaged LET and Detailed LET Spectra. Medical Physics. PMID: None.
Lou K, Mirkovic D, Sun X, Zhu XR, Poenisch F, Grosshans DR, Clark J, Shao Y. Monte Carlo simulation study of using PET for clinical on-line proton beam range verification. Physics in Medicine and Biology. PMID: None.

Invited Articles

McGovern SL, Grosshans DR, Mahajan A. Embryonal Brain Tumors. Cancer J 20(6):397-402, 2014. PMID: 25415685.
Dinh J, Mahajan A, Palmer M, Grosshans DR. Particle therapy for central nervous system tumors in pediatric and adult patients. Translational Cancer Research 1(3). e-Pub 2012. PMID: None.
Grosshans DR, Wefel J. Catechol-O-Methyltransferase Genotype Modulates Cancer Treatment-Related Cognitive Deficits in Breast Cancer Survivors. Breast Diseases 22(4):411-412, 2012. PMID: None.
Grosshans DR. Radiation Therapy for Childhood Cancers. Pediatrics for Parents 27(3):24-25, 2011. PMID: None.

Abstracts

McGovern SL, Johnson J, Kralik SK, Grosshans DR, McAleer MF, Zaky W, Baxter PA, Lin FY, Chintagumpala M, Paulino A. Pseudoprogression after proton therapy of pediatric spinal pilocytic astrocytoma and myxopapillary ependymoma. ISPNO 19th International Symposium on Pediatric Neuro-oncology Virtual Meeting, Nagano, Japan, 2020. PMID: None.
McGovern SL, Lucari B, Jagannath K, Woodhouse KD, McAleer MF, Grosshans DR, Zaky W, Chintagumpala M, Paulino AC. Radiation Timing, Volume and Patterns of Failure in Infant Medulloblastoma. Int. J. Radiat. Oncol, 2020. PMID: None.
Hanania AN, Chintagumpala M, Ludmir EB, Shah VS, McGovern SL, Grosshans DR, McAleer MF, Okcu MF, Baxter P, Su JM, Paulino AC. Clinical Outcomes following Proton Beam Therapy for Sporadic Optic Pathway Glioma. Int. J. Radiat. Oncol, 2020. PMID: None.
Correia D, Giblin M, Bajaj B, Lawell MP, Gallotto S, Perry A, Weyman EA, Paulino AC, Grosshans DR, McAleer MF, McGovern SL, Friedmann A, Yeap BY, MacDonald S, Marcus KJ, Tarbell NJ, Yock TI. Health Outcomes and Quality of Life in a Multi-institutional Prospective Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma. Int. J. Radiat. Oncol, 2020. PMID: None.

Book Chapters

Grosshans DR, Frank SJ, Zhu RX. Adult Central Nervous System Tumors. In: Proton Therapy: Indications, Techniques, and Outcomes. None. Elsevier, None, 2021.
Grosshans DR, Bishop AJ. Craniopharyngioma. In: Radiation Oncology for Pediatric CNS Tumors. None. SPi Global, None, 2018.

Less

Grant & Contract Support

Title:	Customized 3D Tumor Models for Precision Radiotheranostics of Glioblastoma
Funding Source:	NIH/NCI - sub through University of Texas Austin
Role:	PI

Title:	Molecular and Cellular Mechanisms of Neuronal Damage Caused by Anticancer Therapies
Funding Source:	NIH/NCI
Role:	Co-PI

Title:	Neuronal Alterations in the Midbrain Dopaminergic System Function: A Novel Mechanism of Radiation Induced Cognitive Dysfunction
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI

Title:	Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Administrative Core
Funding Source:	NIH/NCI
Role:	Core-Co Lead

Title:	Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Core 1 – Data Management and Computational Support
Funding Source:	NIH/NCI
Role:	Core-Co Lead

Title:	Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy. Project 1: Understanding normal tissue toxicity to identify patients most likely to benefit from proton therapy
Funding Source:	NIH/NCI
Role:	Core Co-Lead

Title:	Integrating patient specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy. Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers
Funding Source:	NIH/NCI
Role:	Project Leader

Title:	Characterization of the cellular mechanisms of radiation induced brain necrosis for clinical intervention
Funding Source:	NIH/NCI
Role:	Principal Investigator-MDACC

Title:	Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model
Funding Source:	NIH/NCI
Role:	PI

Title:	Transforming care through a GEMINI (Glioma Epigenetic and MRI Imaging for Novel Insights) Clinical Trial
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Innovative Biomolecular and Imaging Adaptive Therapy for Patients with Molecular Glioblastoma
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Collaborator

Title:	Imaging of cranial radiotherapy neuroinflammatory sequelae by Positron Emission Tomography
Funding Source:	NIH/NCI – sub through University of Texas Austin
Role:	Co-PI

Title:	Blocking NFKB Improves Cancer Treatment Outcome and Ameliorates Cranial Radiotherapy Sequelae
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI

Title:	Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	Optimizing the Biological Effectiveness of Intensity-Modulated Proton Therapy
Funding Source:	NIH/NCI
Role:	Significant Contributor

Title:	Use of Microbial Based Countermeasures to Mitigate Radiation Induced Intestinal Damage
Funding Source:	NASA, TSRAD-2020
Role:	Co-I

Title:	Counteracting space radiation by targeting neurogenesis in a human brain organoid model
Funding Source:	NASA, TSRAD-2020
Role:	Subaward Principal Investigator

Title:	Image-guided Proton Therapy Using a Novel Monolithic Scintillator-based Radiographic and CT Imaging System
Funding Source:	MD Anderson Cancer Center
Role:	Co-I

Title:	A framework to use DNA repair to IndiVidualizE Radiotherapy (DRIVER)
Funding Source:	MDACC SINF
Role:	Co-I

Title:	Accounting for and harnessing RBE variability in proton therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)
Funding Source:	NIH/NCI
Role:	Executive Committee Member

Title:	Advanced micro-PET/CT/RT System for Translational Radiation Oncology Applications
Funding Source:	NIH/NIBIB
Role:	Co-I

Title:	Novel On-line PET Based Itra-eam Range Measurement and Adaptive Delivery Optimization for Improved Particle Radiation Therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Pre-clinical studies of heavy ions and protons
Funding Source:	Radiation Oncology Strategic Initiative (ROSI)
Role:	PI

Title:	Directed and unbiased studies of synaptic injuries as sequelae of radiotherapy: mapping, sex-dependence, and reversal
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	White Matter Toxicity and Neurocognitive Outcomes in Pediatric Brain Tumor Patients Treated with Proton Beam Radiation Therapy
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	Exploiting DNA repair defects using intensity modulated proton therapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Synaptic basis of deficits in attention and executive function following cranial radiation
Funding Source:	NIH/NCI
Role:	PI

Title:	Improving Survival Outcomes Harnessing the Biological, Immunologic and Physical Properties of Heavy Charged Particles
Funding Source:	MDACC
Role:	Co-I

Title:	The role of orexin signaling in brain radiation-induced fatigue
Funding Source:	Radiological Society of North America (RSNA)
Role:	Mentor

Title:	Characterizing the biologic response of therapeutic protons at the cellular and DNA level in terms of their physical interactions
Funding Source:	AAPM
Role:	Co-I

Title:	Understanding Biological and Physical Factors Affecting Response to Proton Therapy to Improve its Clinical Effectiveness
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Advancing Linear Energy Transfer Models for Biologically Optimized Proton Therapy
Funding Source:	MD Anderson IRG
Role:	PI

Title:	Improving the Clinical Effectiveness and Understanding of the Biophysical Basis - Project 2: Exploratory Phase I/II Clinical Studies to Improve the Therapeutic Ratio of Proton Radiation Therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Improving the Clinical Effectiveness and Understanding of the Biophysical Basis - Project 1: Assessment of Effectiveness of IMPT vs. IMRT through Phase II Randomized Clinical Trials
Funding Source:	NIH/NCI
Role:	Protocol Chair

Title:	Synaptic Mechanisms of Cognitive Decline after Cranial Radiation
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI

Title:	Road to PET Image-Based On-line Proton Beam Range Measurement
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Improving the Clinical Effectiveness and Understanding of the Biophysical Basis – Core A: Administrative Core
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Mapping Proton RBE Variability Using Automated Biology and Monte Carlo Techniques
Funding Source:	NIH/NCI
Role:	PI

Title:	Cognitive Change after Proton RT vs. Photon or Surgery for Pediatric Brain Tumor
Funding Source:	NIH/NCI
Role:	Co-I

Title:	DTI Imaging of Proton Therapy in Pediatric Brain Tumor Patients
Funding Source:	Danish Childhood Cancer Foundation
Role:	Co-I

Title:	Impact of Apolipoprotein E genotype on baseline neurocognition and radiation-induced neurocognitive dysfunction in patients with brain tumors
Funding Source:	Brains Together for a Cure
Role:	Co-I

Title:	The Future Particle Therapy: Physics and Biology of Light Ions
Funding Source:	Sister Institution Network Fund
Role:	Co-I

Title:	Improving Our Understanding and Maximizing the Effectiveness of Proton Therapy
Funding Source:	Center for Radiation Oncology Research
Role:	PI

Title:	Synaptic and Epigenetic Mechanisms of Radiation Induced Cognitive Impairment
Funding Source:	Radiological Society of North America (RSNA)
Role:	Mentor

Title:	Epigenetic Mechanisms of Cognitive Decline after Cranial Radiation
Funding Source:	TJ Martel
Role:	PI

Title:	In-situ PET imaging for adaptive proton therapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Molecular Imaging of Retrograde Nerve Transport
Funding Source:	NIH/NINDS
Role:	Collaborator

Title:	The Role of Notch Signaling Activation in Melanocyte Transformation and Melanoma Progression
Funding Source:	UNCF Merk Postdoctoral Science Research Fellowship Award
Role:	Mentor

Title:	Radiation Induced Changes in Synaptic Function
Funding Source:	American Cancer Society (ACS)
Role:	PI

Title:	Physician Scientist Award
Funding Source:	UT MD Anderson Cancer Center
Role:	Investigator

Title:	Glumate Toxicity as a Potential Mechanism of Cranial Radiation Induced Neuronal Dysfunction
Funding Source:	American Society for Therapeutic Radiology and Oncology (ASTRO)
Role:	PI

Title:	CCSG Scholar Award
Funding Source:	NIH/NCI
Role:	PI

Title:	Characterization of NMDA Receptors in Schizophrenia
Funding Source:	NIH/NIMH
Role:	PI

Title:	Individualized Risk of Neurocognitive Toxicity Following Brain Radiation: Role of Neuroinflammation and Germline Apolipoprotein E Genotype
Funding Source:	Alliance for Clinical Trials in Oncology Foundation
Role:	PI

Title:	Targeting Mitochondrial Damage and Neuroinflammation to Prevent Chemobrain
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Nonclinical Therapeutic Efficacy Study to Assess apoE Mimetic Peptide on Radiation Late Effects
Funding Source:	Department of Defense (DOD)
Role:	Co-PI

Title:	Breaking the fluorescence barrier: 10-probe measurements of synaptic plasticity
Funding Source:	NIH/NINDS
Role:	Collaborator

Title:	Evaluating the Therapeutic Efficacy and Immune Effects of Dual KO NK Cells in Melanoma CNS Metastasis
Funding Source:	NIH/NCI
Role:	Co-PI

Title:	Transforming Brain Tumor Management: "Preoperative Stereotactic Radiosurgery (SRS) Versus Postoperative SRS for Brain Metastases"
Funding Source:	NIH/NCI
Role:	Primary Mentor

Title:	Extended Longevity of 3D Tissues and Microphysiological Systems for Modeling of Acute and Chronic Exposures to Stressors
Funding Source:	NASA
Role:	PI

Title:	Blocking of NFkB abrogates space radiation induced structural and functional neurologic damage
Funding Source:	NIH/NCI
Role:	Co-PI

Title:	An innovative approach to improve the accuracy and consistency of hadrontherapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	The MD Anderson Cancer Center-Huntsman Cancer Institute U19 GTN Center
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Bystander Effects of Intensity-Modulated Proton Therapy: Synaptic Responses in the CNS Tumors
Funding Source:	NIH/NCI
Role:	PD/PI

Title:	Expanding the therapeutic window for radiation in brain tumors with ultra-high dose rate proton FLASH radiotherapy
Funding Source:	R&E Foundation
Role:	Mentor

Title:	Preoperative Versus Postoperative Stereotactic Radiosurgery (SRS) for Brain Metastases
Funding Source:	V Foundation
Role:	Consult

Title:	Sexually dimorphic mechanisms of synaptic and cognitive dysfunction by anti-cancer therapies
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	Identifying Differences in Biological Effects of Proton vs Photon Radiation in Cancer
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	Radiation Dose-Volume Associations with Neurocognitive Change and Late Neurocognitive and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton Radiotherapy
Funding Source:	NIH/NCI
Role:	Subaward Principal Investigator

Title:	Radiosensitivity of Immune Cells as a Function of Dose, Linear Energy Transfer and Ion Species and its Impact on Incidence and Severity of Radiation Induced Immune System Suppression
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Improving Biological Effect Modeling of Ion Therapy: Implementing a Novel High-Accuracy and High-Throughput Biophysical System
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Advancing RBE models for high LET particles beyond the linear-quadratic model
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Space travel conditions can cause executive cognitive dysfunction through NFkB mediated neuroinflammation
Funding Source:	Baylor College of Medicine
Role:	PI

Title:	Radiography and CT using a novel image detector system and approach for image guidance for proton therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Late Neurocognitive and Functional Outcomes and Radiation Dose-Volume Associations with Neurocognitive Change in Pediatric Brain Tumor Patients Treated with Proton Radiotherapy
Funding Source:	Baylor College of Medicine
Role:	PI

Title:	Physical and molecular mechanisms underlying the cellular response to proton therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Advances in the understanding of Ultra-high dose rate FLASH proton therapy for cancer treatment
Funding Source:	University of Texas Austin
Role:	PI

Title:	Comparison of Symptom Toxicities, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients and Survivors Treated with Proton vs. Photon Radiotherapy
Funding Source:	Baylor College of Medicine
Role:	PI

Title:	Automatic Treatment Planning for Proton Therapy: Investigations of Robustly Optimized Intensity Modulated Proton Therapy Incorporating LET/RBE Criteria and Physical and Biological Uncertainties
Funding Source:	University of Texas Austin
Role:	Co-I

Title:	Mitigating acute and late radiation-injury of individual organs systems to improve survival and quality of life
Funding Source:	NIH
Role:	PI

Title:	Understanding and Modeling Biological Effects and Normal Tissues Complications Based on Clinical Outcomes for Proton Radiotherapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Advancing biophysical models for biologically optimized intensity-modulated proton therapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Collaborator

Title:	Harnessing DNA repair defects to enhance anti-tumor immunity using radiation
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Biomarkers for Prediction of Radiation-induced Neurocognitive Toxicity
Funding Source:	NRG Oncology Foundation, Inc
Role:	PI

Title:	A framework to predict radiation response using DNA repair defects
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Investigating Patient, Tumor, and Treatment Factors Underlying Sensitivity of Cancers and Normal Tissues to Proton vs Photon Radiation
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Interpreting DNA damage as a function of particle track structure for intensity-modulated proton therapy
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Investigating Patient, Tumor, and Treatment Factors Underlying Sensitivity of Cancers and Normal Tissues to Proton vs Photon Radiation
Funding Source:	NIH/NCI
Role:	Project Leader

Title:	Investigating Patient, Tumor, and Treatment Factors Underlying Sensitivity of Cancers and Normal Tissues to Proton vs Photon Radiation
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Investigating Patient, Tumor, and Treatment Factors Underlying Sensitivity of Cancers and Normal Tissues to Proton vs Photon Radiation
Funding Source:	NIH/NCI
Role:	Co-Core Leader

Title:	High-accuracy biophysical systems to improve biological effect modeling of clinical proton beams
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Protecting Mitochondria to Prevent Chemobrain
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Overcoming pancreatic cancer radioresistance using for carbon ion therapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Deriving Biological Effectiveness of Protons for Normal Tissues from Clinical Outcomes
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Mark-III 129Xe Gas Polarizer System
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Proton radiography and CT using a novel image detection system and approach based on a monolithic scintillator and digital cameras
Funding Source:	NIH
Role:	Co-I

Title:	Advancing biophysical models for biologically optimized intensity-modulated proton therapy
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Title:	Improving the therapeutic potential of biologically optimized intensity-modulated proton therapy
Funding Source:	Elsa Pardee Foundation
Role:	Co-I

Title:	Advanced Computational and Optimization Methods for Research to Enhance the Potential of Intensity-Modulated Proton Therapy Incorporating Biological Effect and Physical Uncertainties
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Identifying the physical parameters necessary to accurately model the biologic effects of proton beams
Funding Source:	NIH
Role:	Co-PI

Title:	Improving Our Understanding and Modeling of Biological Effects for Heavy Ions – Preparing for Heavy Ions in the US
Funding Source:	NIH
Role:	Co-PI

Title:	A preclinical model of pediatric brain tumor treatment sequelae: A characterization of neurocognition, imaging and molecular changes
Funding Source:	NIH
Role:	Co-I

Title:	Application for the Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Mapping and Modeling the Biologic Effects of Heavy Ions for Clinical Applications – Preparing for Heavy Ion Therapy in Texas
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Multi-PI

Title:	In Search of the Optimum Ion for Radiotherapy in the 3rd Millennium
Funding Source:	NIH/NCI
Role:	Co-I

Title:	Synaptic mechanisms of cognitive deficits after cranial radiation
Funding Source:	NIH/NINDS
Role:	PI

Title:	Epigenetic Mechanisms of Radiation Induced Cognitive Dysfunction
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	PI

CV information above last modified December 20, 2024

David R. Grosshans, M.D., Ph.D.

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David R. Grosshans, M.D., Ph.D.

About Dr. Grosshans

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Education & Training

Degree-Granting Education

Postgraduate Training

Board Certifications

Experience & Service

Academic Appointments

Administrative Appointments/Responsibilities

Other Appointments/Responsibilities

Institutional Committee Activities

Honors & Awards

Professional Memberships

Selected Publications

Peer-Reviewed Articles

Invited Articles

Other Articles

Abstracts

Book Chapters

Grant & Contract Support

Patient Reviews

Request an Appointment

Related Links

Grosshans Laboratory

Radiation Oncology

Experimental Radiation Oncology

Clinical Trials

Help #EndCancer

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