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David E. Ost, M.D., M.P.H., F.A.C.P.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Clinical Research, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

My long-term goal is to understand the factors that contribute to pulmonary morbidity and mortality in cancer patients in order to develop more cost-effective treatments and interventions. My particular area of focus is interventional pulmonology. Areas of interest include diagnosis and staging of lung cancer using endobronchial ultrasound, comparative effectiveness of bronchial stenting, impact of bronchoscopic interventions on quality adjusted survival, and impact of indwelling pleural catheters on quality adjusted survival and health care resource utilization.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd. - Unit 1462
Houston, TX 77030
Phone: 713-792-6238
Fax: 713-749-4922

Education & Training

Degree-Granting Education

2005 Harvard School of Public Health, Boston, MA, MPH, Masters of Public Health
1990 Thomas Jefferson University Medical College, Philadelphia, PA, MD, Medicine
1986 Pennsylvania State University, University Park, PA, BS, Science

Board Certifications

2007 American Board of Internal Medicine, Subspecialty Critical Care
2006 American Board of Internal Medicine
1996 American Board of Internal Medicine, Subspecialty Pulmonary

Honors and Awards

2006 Alfred Sofer Award, American College of Chest Physicians

Professional Memberships

American Association of Bronchoscopy and Interventional Pulmonology
Board of Directors, 2001-2009
American College of Chest Physicians
Chair, American College of Bronchoscopy Registry, ACCP Quality Improvement Registry, Evaluation, and Education (AQuIRE) Program, 2008-present
American Thoracic Society
Planning Committee Chair, 2007-2009
American Thoracic Society
Chair, Nominating Committee ATS Clinical Problems Assembly, 2000

Selected Publications

Peer-Reviewed Original Research Articles
1. Casal RF, Staerkel GA, Ost D, Almeida FA, Uzbeck MH, Eapen GA, Jimenez CA, Nogueras-Gonzalez GM, Sarkiss M, Morice RC. Randomized clinical trial of endobronchial ultrasound needle biopsy with and without aspiration. Chest 142(3):568-573, doi:10.1378/chest.11-0692, 9/2012. e-Pub 12/2011. PMID: 22156610.
2. Ost DE, Gould MK. Decision Making in the Patient with Pulmonary Nodules. Am J Respir Crit Care Med 185(4):363-72, 2/2012. e-Pub 10/2011. PMCID: PMC3361350.
3. Ost DE, Ernst A, Lei X, Feller-Kopman D, Eapen GA, Kovitz KL, Herth FJ, Simoff M, AQuIRE Bronchoscopy Registry. Diagnostic yield of endobronchial ultrasound guided transbronchial needle aspiration: results of the AQuIRE registry. Chest 140(6):1557-1566, 12/2011. e-Pub 6/9/2011. PMID: 21659432.
4. Filner JJ, Bonura EJ, Lau ST, Abounasr KK, Naidich D, Morice RC, Eapen GA, Jimenez CA, Casal RF, Ost D. Bronchoscopic fibered confocal fluorescence microscopy image characteristics and pathologic correlations. J Bronchol Intervent Pulmonol 18(1):23-30, 1/2011.
5. Casal RF, Jimenez CA, Mehran RJ, Eapen GA, Ost D, Sarkiss M, Morice RC. Infected mediastinal bronchogenic cyst successfully treated by endobronchial ultrasound-guided fine-needle aspiration. Ann Thorac Surg 90(4):e52-3, 10/2010. PMID: 20868780.
6. Morice RC, Jimenez CA, Eapen GA, Mehran RJ, Keus L, Ost D. Using quantitative breath sound measurements to predict lung function following resection. J Cardiothorac Surg 5(1). e-Pub 10/2010. PMID: 20939900.
7. Ernst A, Simoff M, Ost D, Michaud G, Chandra D, Herth FJ. A Multi-Center, Prospective, Advanced Diagnostic Bronchoscopy Outcomes Registry. Chest 138(1):165-70, 7/2010. e-Pub 4/2010. PMID: 20363846.
8. Ost DE, Poch D, Fadel A, Wettimuny S, Ginocchio C, Wang XP. Mini-bronchoalveolar lavage quantitative polymerase chain reaction for diagnosis of methicillin-resistant Staphylococcus aureus pneumonia. Crit Care Med 38(7):1536-41, 7/2010. e-Pub 5/2010. PMID: 20473148.
9. Ost D, Eapen GA, Jimenez CA, Morice RC. Improving procedural training and certification in pulmonary medicine. Chest 137(1):6-8, 1/2010. PMID: 20051398.
10. Sterman DH, Mehta AC, Wood DE, Mathur PN, McKenna RJ, Ost DE, Truwit JD, Diaz P, Wahidi MM, Cerfolio R, Maxfield R, Musani AI, Gildea T, Sheski F, Machuzak M, Haas AR, Gonzalez HX, Springmeyer SC, IBV Valve US Pilot Trial Research Team. A multicenter pilot study of a bronchial valve for the treatment of severe emphysema. Respiration 79(3):222-33, 2010. e-Pub 11/2009. PMID: 19923790.
11. Ozcakar B, Martinez CH, Morice RC, Eapen GA, Ost D, Sarkiss MG, Chiu HT, Jimenez CA. Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer. J Cardiothorac Surg 5:63, 2010. PMCID: PMC2933602.
12. Ost D, Shah R, Anasco E, Lusardi L, Doyle J, Austin C, Fein A. A randomized trial of CT fluoroscopic-guided bronchoscopy vs conventional bronchoscopy in patients with suspected lung cancer. Chest 134(3):507-13, 9/2008. e-Pub 7/2008. PMID: 18641093.
13. Ernst A, Simoff M, Ost D, Goldman Y, Herth FJ. Prospective risk-adjusted morbidity and mortality outcome analysis after therapeutic bronchoscopic procedures: results of a multi-institutional outcomes database. Chest 134(3):514-9, 9/2008. e-Pub 7/2008. PMID: 18641088.
14. Godoy MC, Ost D, Geiger B, Novak C, Nonaka D, Vlahos I, Naidich DP. Utility of virtual bronchoscopy-guided transbronchial biopsy for the diagnosis of pulmonary sarcoidosis: report of two cases. Chest 134(3):630-6, 9/2008. e-Pub 5/2008. PMID: 18490401.
15. Ost D, Goldberg J, Rolnitzky L, Rom WN. Survival after surgery in stage IA and IB non-small cell lung cancer. Am J Respir Crit Care Med 177(5):516-23, 3/2008. e-Pub 11/2007. PMCID: PMC2258444.
16. Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, González M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montañez AM, Anzueto A, VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 177(2):170-177, 1/15/2008. e-Pub 10/25/2007. PMID: 17962636.
17. Wood DE, McKenna RJ, Yusen RD, Sterman DH, Ost DE, Springmeyer SC, Gonzalez HX, Mulligan MS, Gildea T, Houck WV, Machuzak M, Mehta AC. A multicenter trial of an intrabronchial valve for treatment of severe emphysema. J Thorac Cardiovasc Surg 133(1):65-73, 1/2007. e-Pub 12/2006. PMID: 17198782.
18. Ost D, Tepper J, Mihara H, Lander O, Heinzer R, Fein A. Duration of anticoagulation following venous thromboembolism: a meta-analysis. JAMA 294:706-15, 2005. PMID: 16091573.
19. Spragg R, Lewis J, Walmrath H, et al for the Venticute Study Group. Effect of recombinant surfactant protein C-based surfactant on the acute-respiratory distress syndrome. N Engl J Med 351:884-92, 2004.
20. Bernard GR, Margolis BD, Shanies HM, Ely EW, Wheeler AP, Levy H, Wong K, Wright T, for the Extended Evaluation of Recombinant Human Activated Protein C United States Investigators. Extended Evaluation of Recombinant Human Activated Protein C United States Trial (ENHANCE US): A Single-Arm, Phase 3B, Multicenter Study of Drotrecogin Alfa (Activated) in Severe Sepsis. Chest 125:2206-2216, 2004.
21. Ost D, Khanna D, Shah R, Hall CS, Shah S, Lesser M, Fein AM. Theory Versus Practice: Impact of spiral computed tomography on the diagnosis of pulmonary embolism in a community hospital setting. Respiration 71:450-7, 2004. PMID: 15467321.
22. Mojavarian A, Ost D. Tracheobronchial Glomus Tumor. J Bronchology 11:188-193, 2004.
23. Ost DE, Hall CS, Joseph G, Ginocchio C, Condon S, Kao E, LaRusso M, Itzla R, Fein AM. Decision analysis of antibiotic and diagnostic strategies in ventilator-associated pneumonia. Am J Respir Crit Care Med 168:1060-7, 11/2003. PMID: 12842855.
24. Friedman D, Shulman L, Ost D, Fein A. Dual stenting of bronchoesophageal fistula. J Bronchol 10:272-275, 2003.
25. Ernst A, Freitag L, Feller-Kopman D, LoCicero J, Ost D. Photodynamic therapy for endobronchial obstruction is safely performed with flexible bronchoscopy. J Bronchol Intervent Pulmonol 10:260-263, 2003.
26. The MATISSE Investigators. Subcutaneous Fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med 349:1695-1702, 2003.
27. Ost D, DeRosiers A, Britt E J, Fein A, Lesser M, Mehta A. Assessment of a bronchoscopy simulator. Am J Respir Crit Care Med 164:1-8, 2001.
28. Ost D, Rozenshtein A, Saffran L, Snider A. The negative predictive value of spiral CT for the diagnosis of pulmonary embolism in patients with nondiagnostic Ventilation-perfusion scans. Am J Med 110:16-21, 2001.
29. Saffron LS, Ost D, Fein AM, Schiff MJ. Outpatient pleurodesis of malignant pleural effusions, using a small bore pigtail catheter. Chest 118:417-22, 2000.
30. Shah S, Ost D. Photodynamic Therapy: A case series demonstrating its role in mechanically ventilated patients. Chest 118:1419-1423, 2000.
31. Ost D, Joseph C, Sogoloff H, Menezes G. Primary pulmonary melanoma: case report and literature review. Mayo Clinic Proc 74:62-66, 1999.
32. Ost D, Yeldandi A, Cugell D. Acute sarcoid myositis: case report and review of the literature. Chest 107:879-82, 1995.
33. Sachs MK, Huang CM, Ost D, Jungkind DL. Failure of dithiothreitol and pronase to reveal a false-positive cryptococcal antigen determination in cerebrospinal fluid. Am J Clin Pathol 96:381-4, 1991.
34. Owen CS, Sykes NL, Shuler RL, Ost D. Non-calcium environmental sensitivity of intracellular Indo-1. Analytical Biochemistry 192:142-8, 1991.

Invited Articles
1. Almeida FA, Uzbeck M, Ost D. Initial evaluation of the nonsmall cell lung cancer patient: diagnosis and staging. Curr Opin Pulm Med 16(4):307-14, 7/2010. PMID: 20453649.
2. Amdo T, Godoy MC, Ost D, Naidich DP. Imaging-bronchoscopic correlations for interventional pulmonology. Thorac Surg Clin 20(1):103-19, 2/2010. PMID: 20378063.
3. Amdo T, Godoy MC, Ost D, Naidich DP. Imaging-bronchoscopic correlations for interventional pulmonology. Radiol Clin North Am 47(2):271-87, 3/2009. PMID: 19249456.
4. Poch DS, Ost DE. What are the important risk factors for healthcare-associated pneumonia? Semin Respir Crit Care Med 30(1):26-35, 2/2009. e-Pub 2/2009. PMID: 19199184.
5. Sarkiss M, Casal R, Ost D, Morice R, Eapen G, Jimenez C. Anesthesia for interventional bronchoscopy. Minverva Pneumol(231-42), 48, 2009.
6. Filner JJ, Ost D. Principles of staging as applied to nonsmall cell lung cancer. Curr Opin Pulm Med 14(4):287-91, 7/2008. PMID: 18520260.
7. Kollef MH, Morrow LE, Baughman RP, Craven DE, McGowan JE, Micek ST, Niederman MS, Ost D, Paterson DL, Segreti J. Health care-associated pneumonia (HCAP): a critical appraisal to improve identification, management, and outcomes--proceedings of the HCAP Summit. Clin Infect Dis 46:S296-334, 4/2008. PMID: 18429676.
8. Gould MK, Fletcher J, Iannettoni MD, Lynch WR, Midthun DE, Naidich DP, Ost DE. Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132(3 Suppl):108S-130S, 9/2007. PMID: 17873164.
9. Shulman L, Ost D. Advances in bronchoscopic diagnosis of lung cancer. Curr Opin Pulm Med 13(4):271-7, 7/2007. PMID: 17534172.
10. Edelson J, Shah R, Ost D. A 45 year old man with left lung hypoperfusion and possible pulmonary embolism. Chest 128(2):1032-6, 8/2005. PMID: 16100204.
11. Shulman L, Ost D. Managing infection in the critical care unit: how can infection control make the ICU safe? Crit Care Clin 21(1):111-28, 1/2005. PMID: 15579356.
12. Ost D, Fein A. Management strategies for the solitary pulmonary nodule. Curr Opin Pulm Med 10:272-8, 2004.
13. Hall CS, Ost D. Effectiveness of programs to decrease antimicrobial resistance in the intensive care unit. Sem Resp Infect 18:112-121, 2003.
14. Ost D. Photodynamic therapy in lung cancer. Methods Mol Med 75:507-26, 2003.
15. Ost D, Fein A. The role of invasive diagnostic techniques in pneumonia. Sem Resp Infect 18:65-67., 2003.
16. Ost D, Fein AM, Feinsilver SH. The solitary pulmonary nodule. New England Journal of Medicine 348:2535-42, 2003.
17. Ost D. The structure of a computer-assisted treatment plan for inpatients- meeting standards and improving care. (Invited commentary). J Information Tech in Healthcare 1:183-185, 2003.
18. Khanna D, Ost D. Life Threatening Infections in the Upper Airway, Part 1. J. Crit Illness 17:10-21, 2002.
19. Khanna D, Ost D. Life Threatening Infections in the Upper Airway, Part 2. J Crit Illness 17:134-140, 2002.
20. Mehrishi S, Ost D. Photodynamic Therapy: How I do it. Journal of Bronchology 9:218-222, 2002.
21. Ost D, Fein AM. Evaluation and Management of the Solitary Pulmonary Nodule. Am J Respir Crit Care Med 162:782-787., 2000.
22. Ost D. Photodynamic Therapy in Lung Cancer. Oncology 14:379-392, 2000.
23. Ost D, Joseph C, Sogoloff H, Menezes G. Pulmonary Melanoma. Resp Dis 6:14-18, 2000.
24. Saffron L, Ost D. Management of Malignant Pleural Effusions. Emergency Medicine:pp 63-71, 6/1999.
25. Ost D. Solitary Pulmonary Nodules. Emergency Medicine:pp 90-97, 10/1998.
26. Ost D. Life Threatening Deep Neck Space Infections. Clin Pulm Med 4:316-23, 1997.
27. Ost D, Filderman A. Evaluation and management of the solitary pulmonary nodule. Contemporary Internal Medicine 8:72-84, 1996.
28. Ost D, Corbridge T. Independent Lung Ventilation. Clinics in Chest Medicine 17:591-602, 1996.

Last updated: 2/22/2013