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David I. Rosenthal

Present Title & Affiliation

Primary Appointment

Professor (Tenured), Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2008 American College of Radiology, Washington, DC, F.A.C.R., Radiation Oncology
1984 University of Miami School of Medicine, Miami, FL, MD, Medicine

Postgraduate Training

1/1990-6/1991 Chief Resident, University North Carolina Hospitals, Chapel Hill, NC
7/1988-6/1991 Radiation Oncology Residency, University of North Carolina Hospitals, Chapel Hill, NC
7/1987-6/1988 Nuclear Radiology Fellowship, University Hospitals of Cleveland, Cleveland, OH
7/1985-6/1987 PG2/3, Otolaryngology, Head and Neck Surgery, Case Western Reserve University Hospitals of Cleveland, Cleveland, OH
6/1984-6/1985 PG1, General Surgery, Jackson Memorial Hospital, Miami, FL

Board Certifications

1/1994 American Board of Radiology (Radiation Oncology)
1/1985 National Board of Medical Examiners

Experience/Service

Academic Appointments

Associate Professor, Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 4/2002-8/2007

Administrative Appointments/Responsibilities

Section Chief, Head and Neck, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 4/2009-present
Director, Head and Neck Translational Research, Division of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 4/2002-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Hull T, Buhler M, Palmer M, Mason B, Rosenthal DI. A comparison of a bilateral wedged field technique to a field-in-field technique for head and neck cancers. Med Dosim. In Press.
2. Moeller BJ, Rana V, Cannon BC, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang K, Chao CC, Chronwoski GM, Frank SJ, Morrison WM, Rosenthal DI, Weber RS, Garden AS, Lippman SM, Schwartz DL. Risk-Adjusted FDG-PET/CT Assessment of Radiation Response in Head and Neck Cancer - A Prospective Evaluation. Journal of Clinical Oncology. In Press.
3. Rosenthal DI, Harris J, Forastiere AA, Weber RS, Ridge JA, Myers JN, Garden AS, Kuettel MR, Sidhu K, Schultz CJ, Trotti A, Ang KK. Early Postoperative Paclitaxel Followed by Concurrent Paclitaxel and Cisplatin With Radiation Therapy for Patients With Resected High-Risk Head and Neck Squamous Cell Carcinoma: Report of the Phase II Trial RTOG 0024. J Clin Oncol, 8/31/2009. e-Pub 8/31/2009. PMID: 19720915.
4. Yildirim G, Morrison WH, Rosenthal DI, Sturgis EM, Papadimitrakopoulou VA, Schwartz DL, Garden AS. Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy. Head Neck, 8/18/2009. e-Pub 8/18/2009. PMID: 19691110.
5. Rosenthal DI, Fuller CD, Barker JL, Mason B, Garcia JA, Lewin JS, Holsinger FC, Stasney CR, Frank SJ, Schwartz DL, Morrison WH, Garden AS, Ang KK. Simple Carotid-Sparing Intensity-Modulated Radiotherapy Technique and Preliminary Experience for T1-2 Glottic Cancer. Int J Radiat Oncol Biol Phys, 8/11/2009. e-Pub 8/11/2009. PMID: 19679406.
6. Schwartz DL, Lobo MJ, Ang KK, Morrison WH, Rosenthal DI, Ahamad A, Evans DB, Clayman G, Sherman SI, Garden AS. Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatment. Int J Radiat Oncol Biol Phys 74(4):1083-91, 7/15/2009. e-Pub 12/25/2008. PMID: 19095376.
7. Garcia MK, Chiang JS, Cohen L, Liu M, Palmer JL, Rosenthal DI, Wei Q, Samuel T, Wang C, Rahlfs T, Chambers MS. Acupuncture for radiation-induced xerostomia in patients with cancer: A pilot study. Head Neck. e-Pub 4/17/2009. PMID: 19378325.
8. Smith GL, Smith BD, Garden AS, Rosenthal DI, Sherman SI, Morrison WH, Schwartz DL, Weber RS, Buchholz TA. Hypothyroidism in older patients with head and neck cancer after treatment with radiation: A population-based study. Head Neck. e-Pub 4/2009. PMID: 19360741.
9. Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang KK, Chao KS, Chronowski GM, Frank SJ, Morrison WH, Rosenthal DI, Weber RS, Garden AS, Lippman SM, Schwartz DL. Prospective Risk-Adjusted [18F]Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography Assessment of Radiation Response in Head and Neck Cancer. J Clin Oncol. e-Pub 3/30/2009. PMID: 19332725.
10. Singh S, Rosenthal DI, Ginsberg LE. Enlargement and Transformation of Thyroglossal Duct Cysts in Response to Radiotherapy: Imaging Findings. AJNR Am J Neuroradiol 30(4). e-Pub 1/8/2009. PMID: 19131415.
11. Cordes B, Williams MD, Tirado Y, Bell D, Rosenthal DI, Al-Dhahri SF, Hanna EY, El-Naggar AK. Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification. Hum Pathol 40(3):283-92, 1/2009. PMID: 19150107.
12. Hsu A, Frank SJ, Ballo MT, Garden AS, Morrison WH, Rosenthal DI, Hatef E, Esmaeli B. Postoperative adjuvant external-beam radiation therapy for cancers of the eyelid and conjunctiva. Opthal Plast Reconstr Surg 6(24):444-449, 12/2008.
13. Rosenthal DI, Chambers MS, Fuller CD, Rebueno NC, Garcia J, Kies MS, Morrison WH, Ang KK, Garden AS. Beam Path Toxicities to Non-Target Structures during Intensity-Modulated Radiation Therapy for Head and Neck Cancer. Int J Radiat Oncol Biol Phys 72(3):747-755, 11/2008.
14. Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang KK, Rosenthal DI. Cerebrovascular disease risk in older head and neck cancer patients with radiotherapy. J Clin Oncol 31(26):5119-5125, 11/2008.
15. Rosenthal DI, Catalano PJ, Haller DG, Landry JC, Sigurdson ER, Spitz FR, Benson AB. Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297. Int J Radiat Oncol Biol Phys 72(1):108-13, 9/1/2008. PMID: 18722265.
16. Li H, Zhu X, Zhang L, Dong L, Tung S, Ahamad A, Chao C, Morrison W, Rosenthal D, Schwartz D, Mohan R, Garden A. Comparison of 2D Radiographic Images and 3D Cone Beam Computed Tomography for Positioning Head-And-Neck Radiotherapy Patients. Int. J. Radiation Oncology Biol. Physs. 71(3):916-925, 7/2008.
17. Schwartz DL, Rana V, Shaw S, Yazbeck C, Ang KK, Morrison WH, Rosenthal DI, Hoff A, Evans DB, Clayman GL, Garden AS, Sherman SI. Postoperative radiotherapy for advanced medullary thyroid cancer-Local disease control in the modern era. Head and Neck 30(7):883-888, 7/2008.
18. Sulman EP, Schwartz DL, Le TT, Ang KK, Morrison WH, Rosenthal DI, Ahamad A, Kies M, Glisson B, Weber R, Garden AS. Imrt Reirradiation of Head and Neck Cancer-Disease Control and Morbidity Outcomes. Int J Radiat Oncol Biol Phys. e-Pub 6/2008. PMID: 18556144.
19. Smith SL, Hessel AC, Luna MA, Malpica A, Rosenthal DI, El-Naggar AK. Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients managed at a a single institution and comparison with reported series. Arch Otolaryngol 134(6):592-595, 6/2008.
20. Rosenthal DI, Mendoza TR, Chambers MS, Burkett VS, Garden AS, Hessell AC, Lewin JS, Ang KK, Kies MS, Gning I, Wang XS, Cleeland CS. The M. D. Anderson symptom inventory-head and neck module, a patient-reported outcome instrument, accurately predicts the severity of radiation-induced mucositis. Int J Radiat Oncol Biol Phys 72(5). e-Pub 5/22/2008. PMID: 18501527.
21. Mandal M, Myers JN, Lippman SM, Johnson FM, Williams MD, Rayala S, Ohshiro K, Rosenthal DI, Weber RS, Gallick GE, El-Naggar AK. Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. Cancer 112(9):2088-2100, 5/2008.
22. Brizel DM, Murphy BA, Rosenthal DI, Pandya KJ, Gluck S, Brizel HE, Meredith RF, Berger D, Chen MG, Mendenhall W. Palifermin and concurrent chemoradiation in head and neck squamous carcinoma: Results of a phase 2, placebo-controlled study and an observational, follow-up study. J Clin Oncol 26(15):2489-2496, 5/2008.
23. Rosenthal DI, Mendoza TR, Chambers MS, Burkett VS, Garden AS, Hessell AC, Lewin JS, Ang KK, Kies MS, Gning I, Wang XS, Cleeland CS. The M.D. Anderson symptom inventory-head and neck module, patient-reported outcome instrument, accurately predicts severity of radiation-induced mucositis. Int J Radiat Oncol Biol Phys. e-Pub 5/2008.
24. Ferreira KA, William WN Jr, Mendonza TR, Kimura M, Kowalski LP, Rosenthal DI, Cleeland CS. Translation of the M.D. Anderson Symptom Inventory head and neck module (MDASI-H&N) to Brazilian Portuguese. Rev. Bras. Cir. Cabeca Pescoco 37(2):109-113, 5/2008.
25. Hutcheson KA, Barringer DA, Rosenthal DI, May AH, Roberts DB, Lewis JS. Swallowing outcomes after radiotherapy for larngeal carcinoma. Arch Otolaryngol Head Neck Surg 134(2):178-183, 2/2008.
26. Petsuksiri J, Frank SJ, Garden AS, Ang KK, Morrison WH, Chao KS, Rosenthal DI, Schwartz DL, Ahamad A, Esmaeli B. Outcomes after radiotherapy for squamous cell carcinoma of the eyelid. Cancer 112(1):111-118, 1/2008.
27. Lupinetti A, Roberts D, Williams M, Kupferman M, Rosenthal D, DeMonte F, El-Naggar AK, Weber RS, Hanna EY. Sinonasal adenoid cystic carcinoma: MD Anderson Cancer Center Experience. Cancer 110(12). e-Pub 12/2007.
28. Williams MD, Roberts D, Blumenschein GR Jr, Temam S, Kies MS, Rosenthal DI, Weber RS, El-Naggar AK. Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients. Am J Surg Pathol 11:1645-1652, 11/2007.
29. O'Daniel JC, Garden AS, Schwartz DL, Wang H, Ang KK, Ahamad A, Rosenthal DI, Morrison WH, Asper JA, Zhang L, Tung SM, Mohan R, Dong L. Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get? Int J Radiat Oncol Biol Phys 69(4):1290-1296, 11/2007.
30. Rosenthal DI. Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes. J Support Oncology 5(9 suppl 4):23-31, 10/2007.
31. Kaszuba SM, Zafereo MD, Rosenthal DI, El-Naggar AD, Weber RS. Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma. Arch Otolaryngol Head Neck Surg 133(6):546-550, 10/2007.
32. Rosenthal DI, Mendoza, TR Chambers MS, Asper JA, Ibrahima Gning I, Kies MS, Weber RS, Lewin JS, Garden AS, Ang KK, Wang XS, Cleeland CS. Measuring head and neck cancer symptom burden: The development and validation of the M.D. Anderson symptom inventory, Head & Neck Module (MDASI-HN). Head and Neck 29(10):923-931, 10/2007.
33. Cmelak AJ, Li S, Goldwasser M, Murphy BA, Adams GL, Cannon M, Pinto H, Rosenthal DI, Gillison M, Forastiere AA. Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: Results Of ECOG 2399. J Clin Oncol 25(25):3971-3977, 9/2007.
34. Bristol IJ, Ahamad A, Garden AS, Morrison WH, Hanna EY, Papadimitrakoupoulou VA, Rosenthal DI, Ang KK. Postoperative radiation for maxillary sinus cancer: long-term outcomes and toxicities of treatment. Int J Radiat Oncol Biol Phys 68(3):719-730, 7/2007.
35. ODaniel JC, Rosenthal DI, Garden AS, Barker JL, Ahamad A, Ang K, Asper JA, Blanco AI, de Crevoisier R, Holsinger C, Patel CB, Schwartz DL, Wang H, Dong L. The effects of dental artifacts, contrast media, and experience on intra-observer contouring variations in head and neck anatomy. Am J Clin Oncol 30(2):191-198, 4/2007.
36. Anné PR, Machtay M, Rosenthal DI, Brizel DM, Morrison WH, Irwin DH, Chougule PB, Estopinal NC, Berson A, Curran WJ, Jr. A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer. Int J Radiat Oncol Biol Phys 67(2):445-452, 2/2007.
37. Garden AS, Morrison WH, Wong PF, Tung SS, Rosenthal DI, Dong L, Mason B, Perkins GH, Ang KK. Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 67:438-444, 2/2007. PMID: 17141972.
38. Chambers MS, Rosenthal DI, Weber RS. Radiation-Induced xerostomia. Head Neck 29(1):58-63, 1/2007.
39. Fuller CD, Wang SJ, Thomas CR Jr, Hoffman HT, Weber RS, Rosenthal DI. Conditional survival in head and neck squamous cell carcinoma: results from the SEER dataset 1973-1998. Cancer 109(7):1331-1343, 2007.
40. Ohshiro K, Rosenthal DI, Koomen JH, Streckfus CF, Chambers M, Kobayashi R, El-Naggar AK. Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma. Int J Onc 30(3):743-9,, 2007.
41. Yom SS, Morrison WH, Ang KK, Rosenthal DI, Perkins GH, Wong PF, Garden AS. Two-field versus three-field irradiation technique in the postoperative treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys 66:469-476, 10/2006. PMID: 16887292.
42. Yom SS, Rosenthal DI, El-Naggar AK, Kies MS, Hessel AC. Merkel cell carcinoma of the tongue and head and neck oral mucosal sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endo 101:761-768, 6/2006. PMID: 16731397.
43. Asper JA, Morrison WH, Rosenthal DI, Ahamad A, Ang KK, Garden AS. Impact of changes to the American Joint Committee on Cancer T classification on outcome prediction in patients with oropharyngeal cancer. Cancer 106:1950-1957, 5/2006. PMID: 16598700.
44. Zhang L, Garden AS, Lo J, Ang KK, Ahamad A, Morrison WH, Rosenthal DI, Chambers MS, Zhu XR, Mohan R, Dong L. Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys 64(5):1559-1569, 4/2006. PMID: 16580505.
45. Simon C, Goepfert H, Rosenthal DI, Roberts D, El-Naggar A, Old M, Diaz EM, Jr, Myers JN. Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival. Eur Arch Otorhinolaryngol 263:313-318, 4/2006. PMID: 16328403.
46. Apisarnthanarax S, Elliott DD, El-Naggar AK, Asper JA, Blanco A, Ang KK, Garden AS, Morrison WH, Rosenthal D, Weber RS, Chao KS. Determining optimal clinical target volume margins in head-and-neck cancer based on microscopic extracapsular extension of metastatic neck nodes. Int J Radiat Oncol Biol Phys 64:678-83, 3/2006. PMID: 16243444.
47. Rosenthal DI, Fuller CD, Machtay M, Algazy KM, Meyer DM, Kaiser LR, Yardley DA, Loiacano ME, Carbone DP. Phase I study of paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced non small cell lung cancer. Journal of Thoracic Oncology 1(1):38-45, 1/2006.
48. Rosenthal Di, Asper JA, Barker JL Jr, Garden AS, Chao KS, Morrison WH, Weber RS, Ang KK. Importance of patient examination to clinical quality assurance in head and neck radiation oncology. Head Neck 28/11:967-73, 2006.
49. Jones HA, Machtay M, Hershock D, Chalian AA, Weber RS, Weinstein GS, Berlin J, Schumacher K, Kligerman MM, Rosenthal DI. Validation of a measurement instrument of symptom distress for patients undergoing chemoradiation for head and neck cancer. Am J Clin Oncol 29(2):158-162, 2006.

Last updated: 9/22/2009