David J. Tweardy, M.D., FIDSA, FACP, FAAS

Peer-Reviewed Articles

1. Kasembeli MM, Kaparos E, Bharadwaj U, Allaw A, Khouri A, Acot B, Tweardy DJ. Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood 141(12):1411-1424, 2023. e-Pub 2022. PMID: 36240433.
2. Robinson P, Magness E, Montoya K, Engineer N, Eckols TK, Rodriguez E, Tweardy DJ. Genetic and Small-Molecule Modulation of STAT3 in a Mouse Model of Crohn's Disease. J Clin Med 11(23), 2022. e-Pub 2022. PMID: 36498596.
3. Tweardy DJ. Drugging "undruggable" disease-causing proteins: focus on signal transducer and activator of transcription (STAT) 3. Trans Am Clin Climatol Assoc 132:61-76, 2022. PMID: 36196170.
4. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol 192:114688, 2021. e-Pub 2021. PMID: 34274354.
5. Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res 169:105637, 2021. e-Pub 2021. PMID: 33932608.
6. Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol 11:708325, 2021. e-Pub 2021. PMID: 34504808.
7. Zhang L, Wang Y, Dong Y, Chen Z, Eckols TK, Kasembeli MM, Tweardy DJ, Mitch WE. Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease. Am J Physiol Renal Physiol 319(1):F84-F92, 2020. e-Pub 2020. PMID: 32475130.
8. Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE. Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab 318(5):E625-E635, 2020. e-Pub 2020. PMID: 32101031.
9. Minus MB, Wang H, Munoz JO, Stevens AM, Mangubat-Medina AE, Krueger MJ, Liu W, Kasembeli MM, Cooper JC, Kolosov MI, Tweardy DJ, Redell MS, Ball ZT. Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Org Biomol Chem 18(17):3288-3296, 2020. PMID: 32286579.
10. Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev 72(2):486-526, 2020. PMID: 32198236.
11. Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW. Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun 11(1):661, 2020. e-Pub 2020. PMID: 32005826.
12. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. Clin Cancer Res 25(13):3996-4013, 2019. e-Pub 2019. PMID: 30867218.
13. Vicente D, Patino M, Marcus R, Lillmoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy DJ, Gottumukkala V, Vauthey JN, Aloia T, Cata JP. Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget 10(5):584-594, 2019. e-Pub 2019. PMID: 30728909.
14. Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci 19(8), 2018. e-Pub 2018. PMID: 30081609.
15. Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy DJ, Phan AT, Hawk E, Javle M, Lee JS, Torres HA, Rashid A, Lenzi R, Hassabo HM, Abaza Y, Shalaby AS, Lacin S, Morris J, Patt YZ, Amos CI, Khaderi SA, Goss JA, Jalal PK, Kaseb AO. Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol 15(11):1791-1799, 2017. e-Pub 2017. PMID: 28579181.
16. Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun 8(1):1447, 2017. e-Pub 2017. PMID: 29129918.
17. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multi-functional effects of a small-molecule STAT3 inhibitor on NASH and HCC in mice. Clin Cancer Res 23(18):5537-5546, 2017. e-Pub 2017. PMID: 28533225.
18. Pedroza M, To S, Assassi S, Wu M, Tweardy DJ, Agarwal SK. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). e-Pub 2017. PMID: 29029263.
19. Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G, Tweardy DJ. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood 128(26):3061-3072, 2016. e-Pub 2016. PMID: 27799162.
20. Gavino AC, Nahmod K, Bharadwaj U, Makedonas G, Tweardy DJ. STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy 71(12):1684-1692, 2016. e-Pub 2016. PMID: 27225906.
21. Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA. Association Between Hepatitis C Virus and Head and Neck Cancers. J Natl Cancer Inst 108(8), 2016. e-Pub 2016. PMID: 27075854.
22. Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol 138(1):187-199, 2016. e-Pub 2016. PMID: 26948077.
23. Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J 110(11):2377-2385, 2016. PMID: 27276256.
24. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget 7(18):26307-26330, 2016. e-Pub 2016. PMID: 27027445.
25. Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep. e-Pub 2016. PMID: 27149849.
26. Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R. The opposing function of STAT3 as an oncoprotein and tumor suppressor is dictated by the expression status of STAT3β in esophageal squamous cell carcinoma. Clin Cancer Res 22(3):691-703, 2016. e-Pub 2015. PMID: 26405196.
27. Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem 291(9):4732-4741, 2016. e-Pub 2015. PMID: 26706127.
28. Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK. STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J 30(1):129-140, 2016. e-Pub 2015. PMID: 26324850.
29. Zheng M, Turton KB, Zhu F, Li Y, Grindle KM, Annis DS, Lu L, Drennan AC, Tweardy DJ, Bharadwaj U, Mosher DF, Rui L. A mix of S and delta-S variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis 4:e184, 2016. e-Pub 2016. PMID: 26727576.
30. Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int 2016:1959270, 2016. e-Pub 2016. PMID: 26981525.
31. Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer 90(2):182-190, 2015. e-Pub 2015. PMID: 26410177.
32. Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity. Angew Chem Int Ed Engl 54(44):13085-13089, 2015. e-Pub 2015. PMID: 26480340.
33. Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem 290(17):11177-11187, 2015. e-Pub 2015. PMID: 25787076.
34. Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Adam A, Torres D, Zhang X, Dobrolecki LE, Wei W, Lewis MT, Dave B, Chang JC, Landis MD, Creighton CJ, Mancini MA, Tweardy DJ. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene 0(11):1341-1353, 2015. e-Pub 2014. PMID: 24681959.
35. Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci 16(11):26706-26720, 2015. e-Pub 2015. PMID: 26561808.
36. Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhou M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF. Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species . PLoS One 10(12):e0143964, 2015. e-Pub 2015. PMID: 26645674.
37. Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells 32(10):2571-2582, 2014. PMID: 24891218.
38. Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG. Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor. FEBS Lett 588(13):2133-2140, 2014. e-Pub 2014. PMID: 24846140.
39. Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM. Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma 55(5):1194-1197, 2014. e-Pub 2013. PMID: 23829279.
40. Chatzimpaloglou A, Kolosov M, Eckols TK, Tweardy DJ, Sarli V. Synthetic and biological studies of phaeosphaerides. J Org Chem 79(9):4043-4054, 2014. e-Pub 2014. PMID: 24735379.
41. Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol 12(4):e1001844, 2014. e-Pub 2014. PMID: 24756126.
42. Thacker S, Moran A, Lionakis M, Mastrangelo MA, Halder T, del Pilar Huby M, Wu Y, Tweardy DJ. Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect 68(3):231-241, 2014. e-Pub 2013. PMID: 24291043.
43. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int 2014:247182, 2014. e-Pub 2014. PMID: 25530957.
44. Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel) 6(4):2012-2034, 2014. e-Pub 2014. PMID: 25268166.
45. Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ. Contribution of chaperones to STAT pathway signaling. JAK-STAT 3(3):e970459, 2014. e-Pub 2014. PMID: 26413421.
46. Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab 18(3):368-379, 2013. PMID: 24011072.
47. Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F. A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci 126(Pt 11):2446-2458, 2013. e-Pub 2013. PMID: 23572509.
48. Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S, Children's Oncology Group. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood 121(7):1083-1093, 2013. e-Pub 2012. PMID: 23243289.
49. Morrison AC, Moran A, Patel S, Vidaurre Mdel P, Carrick MM, Tweardy DJ. Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect 66(1):87-94, 2013. e-Pub 2012. PMID: 23063873.
50. Thacker SA, Robinson P, Abel A, Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep 3:1187, 2013. e-Pub 2013. PMID: 23378918.
51. Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife 2:e00996, 2013. e-Pub 2013. PMID: 24381245.
52. Liao KS, Lehman SM, Tweardy DJ, Donlan RM, Trautner BW. Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters. J Appl Microbiol 113(6):1530-1539, 2012. e-Pub 2012. PMID: 22985454.
53. Trautner BW, Lopez AI, Kumar A, Siddiq DM, Liao KS, Li Y, Tweardy DJ, Cai C. Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens. Nanomedicine 8(3):261-270, 2012. e-Pub 2011. PMID: 22197726.
54. Weatherhead JE, Tweardy DJ. Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg?. J Infect 64(2):225-227, 2012. e-Pub 2011. PMID: 21945880.
55. Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog 8(2):e1002489, 2012. e-Pub 2012. PMID: 22346746.
56. Roig IL, Musher DM, Tweardy DJ. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis 54(1):91-94, 2012. e-Pub 2011. PMID: 22042876.
57. Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One 7(8):e30207, 2012. e-Pub 2012. PMID: 22879872.
58. Kelly JD, Teeter LD, Graviss EA, Tweardy DJ. Intracranial tuberculomas in adults: a report of twelve consecutive patients in Houston, Texas. Scand J Infect Dis 43(10):785-791, 2011. e-Pub 2011. PMID: 21696248.
59. Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood 117(21):5701-5709, 2011. e-Pub 2011. PMID: 21447830.
60. Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B, Tweardy DJ. IL-6-mediated activation of Stat3α prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One 6(6):e21449, 2011. e-Pub 2011. PMID: 21738667.
61. Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol 2010:597086, 2010. e-Pub 2010. PMID: 20150970.
62. Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood 115(3):643-652, 2010. e-Pub 2009. PMID: 19965660.
63. Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy DJ, Musher DM. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore) 88(3):154-159, 2009. PMID: 19440118.
64. Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci 2(1):41-49, 2009. PMID: 20443866.
65. Kasembeli MM, Xu X, Tweardy DJ. SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed) 14:1010-1022, 2009. e-Pub 2009. PMID: 19273114.
66. Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One 4(3):e4783, 2009. e-Pub 2009. PMID: 19274102.
67. Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med 2(1):76-86, 2009. e-Pub 2009. PMID: 19436834.
68. Robinson P, Martin P, Garza A, D'Souza M, Mastrangelo MA, Tweardy DJ. Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol 94(5):1150-1154, 2008. PMID: 18576802.
69. Garza A, Lackner A, Aye P, D'Souza M, Martin P, Borda J, Tweardy DJ, Weinstock J, Griffiths J, Robinson P. Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol 37(3):109-115, 2008. PMID: 18547256.
70. Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of Stat3alpha. Int J Clin Exp Med 1(3):213-247, 2008. e-Pub 2008. PMID: 18997875.
71. Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One 3(2):e1605, 2008. e-Pub 2008. PMID: 18270592.
72. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem 282(48):34958-34967, 2007. e-Pub 2007. PMID: 17855361.
73. Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol 82(4):975-985, 2007. e-Pub 2007. PMID: 17634277.
74. Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun 75(3):1137-1143, 2007. e-Pub 2006. PMID: 17158891.
75. Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect 54(2):e99-e101, 2007. e-Pub 2006. PMID: 16824611.
76. Goetzl L, Zighelboim I, Badell M, Rivers J, Mastrangèlo MA, Tweardy DJ, Suresh MS. Maternal corticosteroids to prevent intrauterine exposure to hyperthermia and inflammation: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 195(4):1031-1037, 2006. e-Pub 2006. PMID: 16875647.
77. Tweardy DJ, Khoshnevis MR, Yu B, Mastrangelo MA, Hardison EG, López JA. Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock 26(4):386-390, 2006. PMID: 16980886.
78. Qiu J, Wong J, Tweardy DJ, Dong S. Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Oncogene 25(28):3982-3993, 2006. e-Pub 2006. PMID: 16474840.
79. Shao H, Xu X, Jing N, Tweardy DJ. Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. J Immunol 176(5):2933-2941, 2006. PMID: 16493051.
80. Arikan AA, Yu B, Mastrangelo MA, Tweardy DJ. Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med 34(3):771-777, 2006. PMID: 16521270.
81. Jing N, Zhu Q, Yuan P, Li Y, Mao L, Tweardy DJ. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther 5(2):279-286, 2006. PMID: 16505101.
82. Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis 192(10):1741-1748, 2005. e-Pub 2005. PMID: 16235172.
83. Wehner S, Schwarz NT, Hundsdoerfer R, Hierholzer C, Tweardy DJ, Billiar TR, Bauer AJ, Kalff JC. Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery 137(4):436-446, 2005. PMID: 15800492.
84. Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol 288(3):H1272-H1277, 2005. PMID: 15706046.
85. Brundage SI, Zautke NA, Holcomb JB, Spain DA, Lam JC, Mastrangelo MA, Macaitis JM, Tweardy DJ. Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. J Trauma 57(5):970-977; discussion 977-978, 2004. PMID: 15580019.
86. Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 64(18):6603-6609, 2004. PMID: 15374974.
87. Ono M, Yu B, Hardison EG, Mastrangelo MA, Tweardy DJ. Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. Shock 21(6):519-525, 2004. PMID: 15167680.
88. Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol 24(10):4465-4475, 2004. PMID: 15121864.
89. Shao H, Xu X, Mastrangelo MA, Jing N, Cook RG, Legge GB, Tweardy DJ. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem 279(18):18967-18973, 2004. e-Pub 2004. PMID: 14966128.
90. Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 286(2):G225-G233, 2004. PMID: 14715517.
91. Jing N, Li Y, Xu X, Sha W, Li P, Feng L, Tweardy DJ. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 22(11):685-696, 2003. PMID: 14659041.
92. Brundage SI, Schreiber MA, Holcomb JB, Zautke N, Mastrangelo MA, Xq X, Macaitis J, Tweardy DJ. Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine. J Surg Res 113(1):74-80, 2003. PMID: 12943813.
93. Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res 63(14):3923-3930, 2003. PMID: 12873986.
94. Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Aoki N, Meng ZH, Tweardy DJ, Hoots K. The effect of recombinant factor VIIa on non-coagulopathic pigs with grade V liver injuries. J Am Coll Surg 196(5):691-697, 2003. PMID: 12742197.
95. Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Arch Orthop Trauma Surg 123(2-3):55-59, 2003. e-Pub 2003. PMID: 12721681.
96. Kalff JC, Türler A, Schwarz NT, Schraut WH, Lee KK, Tweardy DJ, Billiar TR, Simmons RL, Bauer AJ. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237(3):301-315, 2003. PMID: 12616113.
97. Dong S, Qiu J, Stenoien DL, Brinkley WR, Mancini MA, Tweardy DJ. Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene 22(6):858-868, 2003. PMID: 12584566.
98. Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood 99(8):2637-2646, 2002. PMID: 11929748.
99. Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, Harbrecht BG. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock 17(2):98-103, 2002. PMID: 11837796.
100. Hierholzer C, Billiar TR, Tweardy DJ. Requirements for NF-kappaB activation in hemorrhagic shock. Arch Orthop Trauma Surg 122(1):44-47, 2002. PMID: 11995880.
101. Shao H, Quintero AJ, Tweardy DJ. Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood 98(13):3853-3856, 2001. PMID: 11739197.
102. Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Essential role for IL-6 in post-resuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol 280(2):C343-C351, 2001. PMID: 11208530.
103. Hierholzer C, Kalff JC, Chakraborty A, Watkins SC, Billiar TR, Bauer AJ, Tweardy DJ. Impaired gut contractility following hemorrhagic shock is accompanied by IL-6 and G-CSF production and neutrophil infiltration. Dig Dis Sci 46(2):230-241, 2001. PMID: 11281168.
104. Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ. Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock. Arch Orthop Trauma Surg 121(4):219-222, 2001. PMID: 11317684.
105. Chakraborty A, Dyer KF, Tweardy DJ. Delineation and mapping of Stat5 isoforms activated by granulocyte colony-stimulating factor in myeloid cells. Blood Cells Mol Dis 26(4):320-330, 2000. PMID: 11042034.
106. Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock. Shock 14(1):41-48, 2000. PMID: 10909892.
107. White SM, Alarcon MH, Tweardy DJ. Inhibition of granulocyte colony-stimulating factor-mediated myeloid maturation by low level expression of the differentiation-defective class IV granulocyte colony-stimulating factor receptor isoform. Blood 95(11):3335-3340, 2000. PMID: 10828013.
108. Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR. Induced nitric oxide inhibits IL-6-induced Stat3 activation and type II acute phase mRNA expression. Shock 13(6):441-445, 2000. PMID: 10847630.
109. Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC. Interleukin-6 induces prostate cancer cell growth accompanied by activation of Stat3 signaling pathway . Prostate 42(3):239-242, 2000. PMID: 10639195.
110. Hierholzer C, Kalff JC, Audolfsson G, Billiar TR, Tweardy DJ, Bauer AJ. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation 68(9):1244-1254, 1999. PMID: 10573059.
111. Menezes J, Hierholzer C, Watkins SC, Lyons V, Peitzman AB, Billiar TR, Tweardy DJ, Harbrecht BG. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. Am J Physiol 277(1 Pt 1):G144-G151, 1999. PMID: 10409161.
112. Chakraborty A, Dyer KF, Cascio M, Mietzner TA, Tweardy DJ. Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood 93(1):15-24, 1999. PMID: 9864141.
113. Kirkwood JM, Farkas DL, Chakraborty A, Dyer KF, Tweardy DJ, Abernethy JL, Edington HD, Donnelly SS, Becker D. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med 5(1):11-20, 1999. PMID: 10072444.
114. Hierholzer C, Kalff JC, Bednarski B, Memarzadeh F, Kim YM, Billiar TR, Tweardy DJ. Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock. Arch Orthop Trauma Surg 119(5-6):332-336, 1999. PMID: 10447634.
115. Chakraborty A, Tweardy DJ. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol 64(5):675-680, 1998. PMID: 9823774.
116. Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res 4(11):2913-2921, 1998. PMID: 9829760.
117. Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest 102(7):1385-1392, 1998. PMID: 9769331.
118. Hierholzer C, Kalff JC, Omert L, Tsukada K, Loeffert JE, Watkins SC, Billiar TR, Tweardy DJ. Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol 275(3 Pt 1):L611-L621, 1998. PMID: 9728057.
119. Hierholzer C, Kalff JC, Billiar TR, Bauer A, Tweardy DJ. Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile. Transplant Proc 30(6):2647, 1998. PMID: 9745531.
120. Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol 13(2):375-378, 1998. PMID: 9664135.
121. Chakraborty A, Tweardy DJ. STAT3 and G-CSF-induced myeloid differentiation. Leuk Lymphoma 30(5-6):433-442, 1998. PMID: 9711905.
122. He Y, Zeng Q, Drenning SD, Melhem MF, Tweardy DJ, Huang L, Grandis JR. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst 90(14):1080-1087, 1998. PMID: 9672256.
123. White SM, Ball ED, Ehmann WC, Rao AS, Tweardy DJ. Increased expression of the differentiation-defective granulocyte colony-stimulating factor receptor mRNA isoform in acute myelogenous leukemia. Leukemia 12(6):899-906, 1998. PMID: 9639418.
124. Grandis JR, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD, Tweardy DJ. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90(11):824-832, 1998. PMID: 9625170.
125. Gregory SH, Wing EJ, Danowski KL, van Rooijen N, Dyer KF, Tweardy DJ. IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol 160(12):6056-6061, 1998. PMID: 9637522.
126. Grandis JR, Chakraborty A, Zeng Q, Melhem MF, Tweardy DJ. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem 69(1):55-62, 1998. PMID: 9513046.
127. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 187(6):917-928, 1998. PMID: 9500794.
128. Hierholzer C, Kelly E, Lyons V, Roedling E, Davies P, Billiar TR, Tweardy DJ. G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia. J Leukoc Biol 63(2):169-174, 1998. PMID: 9468275.
129. Grandis JR, Tweardy DJ, Melhem MF. Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin Cancer Res 4(1):13-20, 1998. PMID: 9516947.
130. Hierholzer C, Kalff JC, Billiar TR, Tweardy DJ. Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock. Arch Orthop Trauma Surg 117(6-7):372-375, 1998. PMID: 9709854.
131. Hierholzer C, Kelly E, Tsukada K, Loeffert E, Watkins S, Billiar TR, Tweardy DJ. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Am J Physiol 273(5 Pt 1):L1058-L1064, 1997. PMID: 9374735.
132. Grandis JR, Chakraborty A, Melhem MF, Zeng Q, Tweardy DJ. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene 15(4):409-416, 1997. PMID: 9242377.
133. Perumal NB, Kenniston TW, Tweardy DJ, Dyer KF, Hoffman R, Peschon J, Appasamy PM. TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. J Immunol 158(12):5744-5750, 1997. PMID: 9190924.
134. Hierholzer C, Kelly E, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase. Arch Orthop Trauma Surg 116(3):173-176, 1997. PMID: 9061173.
135. Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ. Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood 88(7):2442-2449, 1996. PMID: 8839834.
136. Grandis JR, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 78(6):1284-1292, 1996. PMID: 8826952.
137. Morel BF, Burke MA, Kalagnanam J, McCarthy SA, Tweardy DJ, Morel PA. Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model. Bull Math Biol 58(3):569-594, 1996. PMID: 8688839.
138. Grandis JR, Zeng Q, Tweardy DJ. Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines. Nat Med 2(2):237-240, 1996. PMID: 8574972.
139. Tweardy DJ, Wright TM, Ziegler SF, Baumann H, Chakraborty A, White SM, Dyer KF, Rubin KA. Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood 86(12):4409-4416, 1995. PMID: 8541528.
140. Prezioso JA, Wang J, Kim M, Duty L, Tweardy DJ, Gorelik E. Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine 7(6):517-525, 1995. PMID: 8580367.
141. Lai CF, Morella KK, Wang Y, Kumaki S, Gearing D, Ziegler SF, Tweardy DJ, Campos SP, Baumann H. Function of hematopoietin receptor subunits in hepatic cells and fibroblasts. Ann N Y Acad Sci 762:189-205; discussion 206, 1995. PMID: 7545363.
142. Tkatch LS, Rubin KA, Ziegler SF, Tweardy DJ. Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J Leukoc Biol 57(6):964-971, 1995. PMID: 7540644.
143. Morel PA, Chang HJ, Wilson JW, Conte C, Falkner D, Tweardy DJ, Medsger TA. HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies. Hum Immunol 42(1):35-42, 1995. PMID: 7751158.
144. Su GL, Freeswick PD, Geller DA, Wang Q, Shapiro RA, Wan YH, Billiar TR, Tweardy DJ, Simmons RL, Wang SC. Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. J Immunol 153(2):743-752, 1994. PMID: 8021509.
145. Morel PA, Chang HJ, Wilson JW, Conte C, Saidman SL, Bray JD, Tweardy DJ, Medsger TA. Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele. Hum Immunol 40(2):101-110, 1994. PMID: 7928439.
146. Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 91(11):4683-4687, 1994. PMID: 8197119.
147. Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation. Blood 83(3):713-723, 1994. PMID: 8298134.
148. Steinman RA, Tweardy DJ. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood 83(1):119-127, 1994. PMID: 8274731.
149. Tkatch LS, Tweardy DJ. Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function. Lymphokine Cytokine Res 12(6):477-488, 1993. PMID: 7510132.
150. Wang SC, Morel PA, Wang Q, Jordan ML, Simmons RL, Tweardy DJ. A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. Transplantation 56(4):978-985, 1993. PMID: 7692640.
151. Geller DA, Nguyen D, Shapiro RA, Nussler A, Di Silvio M, Freeswick P, Wang SC, Tweardy DJ, Simmons RL, Billiar TR. Cytokine induction of interferon regulatory factor-1 in hepatocytes. Surgery 114(2):235-242, 1993. PMID: 7688150.
152. Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53(15):3579-3584, 1993. PMID: 8339264.
153. Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction. Blood 81(10):2671267-8, 1993. PMID: 8490177.
154. Grandis JR, Tweardy DJ. TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl 17F:188-191, 1993. PMID: 8412192.
155. Geller DA, Kispert PH, Su GL, Wang SC, Di Silvio M, Tweardy DJ, Billiar TR, Simmons RL. Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. Arch Surg 128(1):22-27; discussion 27-28, 1993. PMID: 8418776.
156. Grandis JR, Tweardy DJ. The role of peptide growth factors in head and neck carcinoma. Otolaryngol Clin North Am 25(5):1105-1115, 1992. PMID: 1408194.
157. Wang SC, Jordan ML, Tweardy DJ, Wright J, Hoffman RA, Simmons RL. FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. J Surg Res 53(2):199-202, 1992. PMID: 1383612.
158. Gregory SH, Wing EJ, Tweardy DJ, Shadduck RK, Lin HS. Primary listerial infections are exacerbated in mice administered neutralizing antibody to macrophage colony-stimulating factor. J Immunol 149(1):188-193, 1992. PMID: 1535085.
159. Tweardy DJ, Morel PA, Mott PL, Glazer EW, Zeh HJ, Sakurai M. Modulation of myeloid proliferation and differentiation by monoclonal antibodies directed against a protein that interacts with the interleukin-3 receptor. Blood 80(2):359-366, 1992. PMID: 1378315.
160. Tweardy DJ, Anderson K, Cannizzaro LA, Steinman RA, Croce CM, Huebner K. Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood 79(5):1148-1154, 1992. PMID: 1371413.
161. Wang SC, Zeevi A, Jordan ML, Simmons RL, Tweardy DJ. FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. Transplant Proc 23(6):2920-2922, 1991. PMID: 1721312.
162. Morel PA, Walker JA, Livingstone AM, Tweardy DJ, Cairns JS. Proto-oncogene transcription after activation of Th-1 and Th-2 cells. Ann N Y Acad Sci 636:386-389, 1991. PMID: 1838913.
163. Tweardy DJ, Morel PA, Herberman RB, Sakurai M. Inhibition of growth of mouse leukemic cell lines in vitro and in vivo by a monoclonal antibody that recognizes an interleukin 3 receptor-associated protein. Cancer Res 51(16):4355-4359, 1991. PMID: 1868459.
164. Tweardy DJ, Glazer EW, Mott PL, Anderson K. Modulation by tumor necrosis factor-alpha of human astroglial cell production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). J Neuroimmunol 32(3):269-278, 1991. PMID: 1709645.
165. Morel PA, Schreurs J, Townsend K, Gross M, Chiller JM, Tweardy DJ. Identification of a novel protein capable of interacting with the IL-3 receptor. J Immunol 146(7):2295-2304, 1991. PMID: 2005398.
166. Ford HR, Hoffman RA, Tweardy DJ, Kispert P, Wang S, Simmons RL. Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation 51(3):656-661, 1991. PMID: 2006523.
167. Wang SC, Tweardy DJ, Ford HR, Hoffman RA, Simmons RL. Cytokine products of T-helper 2 (Th2) cells are present in rejecting sponge matrix allografts. Transplant Proc 23(1 Pt 1):809-810, 1991. PMID: 1824998.
168. Tweardy DJ, Sasaki M, Cardamone JJ, McCoy JP, Bonidie MJ, Signorella AP. Production of laminin B2 chain protein and messenger RNA by a murine neutrophil precursor cell line, 32Dc13. Blood 76(7):1398-1404, 1990. PMID: 1698480.
169. Tweardy DJ, Mott PL, Glazer EW. Monokine modulation of human astroglial cell production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. I. Effects of IL-1 alpha and IL-beta. J Immunol 144(6):2233-2241, 1990. PMID: 1690240.
170. Sriwanthana B, Hemachudha T, Griffin DE, Manutsathit S, Tweardy DJ, Phanuphak P. Lymphocyte subsets in human encephalitic and paralytic rabies. Acta Neurol Scand 80(4):287-289, 1989. PMID: 2816284.
171. Rovera G, Tweardy DJ, Santoli D, Altmann S, Valtieri M, Lange B. Proliferation and differentiation of human myelogenous leukemia and preleukemia cells in culture: identification of stimulatory and suppressor growth factors. Haematologica 72(6 Suppl):104-110, 1987. PMID: 3127285.
172. Tweardy DJ, Cannizzaro LA, Palumbo AP, Shane S, Huebner K, Vantuinen P, Ledbetter DH, Finan JB, Nowell PC, Rovera G. Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of the G-CSF gene to chromosome band 17q21. Oncogene Res 1(3):209-220, 1987. PMID: 2453015.
173. Rich EA, Tweardy DJ, Fujiwara H, Ellner JJ. Spectrum of immunoregulatory functions and properties of human alveolar macrophages. Am Rev Respir Dis 136(2):258-265, 1987. PMID: 2956914.
174. Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altmann S, Santoli D, Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol 138(11):3829-3835, 1987. PMID: 2438328.
175. Valtieri M, Santoli D, Caracciolo D, Kreider BL, Altmann SW, Tweardy DJ, Gemperlein I, Mavilio F, Lange B, Rovera G. Establishment and characterization of an undifferentiated human T leukemia cell line which requires granulocyte-macrophage colony stimulatory factor for growth. J Immunol 138(11):4042-4050, 1987. PMID: 2953797.
176. Tweardy DJ, Osman GS, el Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly. J Clin Microbiol 25(5):768-773, 1987. PMID: 2953755.
177. Salata RA, Lederman MM, Shlaes DM, Jacobs MR, Eckstein E, Tweardy DJ Toossi Z, Chmielewski R, Marino J, King CH. Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients. Am Rev Respir Dis 135(2):426-432, 1987. PMID: 3101559.
178. Tweardy DJ, Caracciolo D, Valtieri M, Rovera G. Tumor-derived growth factors that support proliferation and differentiation of normal and leukemic hemopoietic cells. Ann N Y Acad Sci 511:30-38, 1987. PMID: 2830826.
179. Tweardy DJ, Fujiwara H, Scillian JJ, Ellner JJ. Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Cell Immunol 100(1):34-46, 1986. PMID: 2943410.
180. Santoli D, Tweardy DJ, Ferrero D, Kreider BL, Rovera G. A suppressor lymphokine produced by human T leukemia cell lines. Partial characterization and spectrum of activity against normal and malignant hemopoietic cells. J Exp Med 163(1):18-40, 1986. PMID: 2416868.
181. Tweardy DJ. Relapsing toxic shock syndrome in the puerperium. JAMA 253(22):3249-3250, 1985. PMID: 3999307.
182. Croce CM, Isobe M, Palumbo A, Puck J, Ming J, Tweardy DJ, Erikson J, Davis M, Rovera G. Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science 227(4690):1044-1047, 1985. PMID: 3919442.
183. Ellner JJ, Tweardy DJ, Osman GS, Wilson C, El Kholy A, Rocklin RE. Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with Schistosoma mansoni. J Infect Dis 151(2):320-324, 1985. PMID: 3155782.
184. Shlaes DM, Lederman MM, Chmielewski R, Tweardy DJ, Krause G, Saffai C. Sputum elastin fibers and the diagnosis of necrotizing pneumonia. Chest 85(6):763-766, 1984. PMID: 6723386.
185. Tweardy DJ, Fujiwara H, Ellner JJ. Enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Trans Assoc Am Physicians 97:353-364, 1984. PMID: 6442952.
186. Tweardy DJ, Schacter BZ, Ellner JJ. Association of altered dynamics of monocyte surface expression of human leukocyte antigen DR with immunosuppression in tuberculosis. J Infect Dis 149(1):31-37, 1984. PMID: 6607294.
187. Tweardy DJ, Jacobs MR, Speck WT. Susceptibility of penicillin-resistant pneumococci to eighteen antimicrobials: implications for treatment of meningitis. J Antimicrob Chemother 12(2):133-139, 1983. PMID: 6555189.
188. Shlaes DM, Lederman M, Chmielewski R, Tweardy DJ, Wolinsky E. Elastin fibers in the sputum of patients with necrotizing pneumonia. Chest 83(6):885-889, 1983. PMID: 6851690.
189. Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Abnormalities of immunosuppression in patients with hepatosplenic schistosomiasis mansoni. Trans Assoc Am Physicians 96:392-400, 1983. PMID: 6238469.

Invited Articles

1. Tweardy DJ, Chang JC. Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol 29(18):2443-4, 2011. e-Pub 2011. PMID: 21576641.
2. Diaz FL, Tweardy DJ, Shellock FG. Cervical external immobilization devices: evaluation of magnetic resonance imaging issues at 3.0 Tesla. Spine (Phila Pa 1976) 35(4):411-5, 2010. PMID: 20110847.
3. Tweardy DJ, Belmont JW. "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. Transl Res 154(6):288-94, 2009. e-Pub 2009. PMID: 19931194.
4. Ivancic PC, Beauchman NN, Tweardy DJ. Effect of halo-vest components on stabilizing the injured cervical spine. Spine (Phila Pa 1976) 34(2):167-75, 2009. PMID: 19139667.
5. Weerasinghe P, Li Y, Guan Y, Zhang R, Tweardy DJ, Jing N. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate 68(13):1430-42, 2008. PMID: 18615483.
6. Trautner BW, Cevallos ME, Li H, Riosa S, Hull RA, Hull SI, Tweardy DJ, Darouiche RO. Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference. J Infect Dis 198(6):899-906, 2008. PMID: 18643750.
7. Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 18(10):3941-51, 2007. e-Pub 2007. PMID: 17671166.
8. Tweardy DJ, Jing N. Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc 117:33-51; discussion 51-2, 2006. PMID: 18528463.
9. Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol 3(3):261-7, 2006. PMID: 24980527.
10. Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 16(6):601-7, 2005. PMID: 15930886.
11. Jing N, Sha W, Li Y, Xiong W, Tweardy DJ. Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des 11(22):2841-54, 2005. PMID: 16101441.
12. Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des 11(22):2873-87, 2005. PMID: 16101443.
13. Dong S, Chen SJ, Tweardy DJ. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leuk Lymphoma 44(12):2023-9, 2003. PMID: 14959844.

Book Chapters

1. Morel PA, Townsend K, Gross M, Chiller JM, Tweardy DJ. Monoclonal antibodies to an IL-3-receptor protein. In: Hematopoiesis. Alan R. Liss, Inc: New York, 133-143, 1990.
2. Rovera G, Tweardy DJ, Santoli D, Kreider B, Valtieri M, Gemperlein I, Mavilio F. Granulopoiesis: In search of growth and differentiation of regulatory genes. In: Phenotypic and Functional Aspects of Hematopoiesis. Raven Press: NY, 17, 1988.
3. Tweardy DJ, Santoli D, Dietzschold B , Wheelock MJ , Altmann SW , Rovera G. T leukemia-derived suppressor lymphokine (TLSL): Biology and biochemistry. In: : Immune Regulation by Characterized Peptides. UCLA Symposia on Molecular and Cellular Biology. Alan R. Liss, Inc: NY, 485-494, 1986.
4. Tweardy DJ, Bishop YMM, Donner AP, Klerman GL, Peterson OL, ReichP , Lister-Rosenoer LM , Rosenoer VM , Rosner BA. Lithium maintenance therapy of manic-depressive disorders. In: Current Controversies in Therapeutics. SP Medical Scientific Books: NY, NY, 1980.