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Dawid Schellingerhout, M.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Schellingerhout joined M D Anderson in 2004 from Massachusetts General Hospital and Harvard Medical School.  He regularly publishes in the molecular and neurological imaging literature, and regularly presents data at national and international scientifice meetings.

Dr. Schellingerhout’s research centers on investigating the Nervous System with molecular and novel imaging technologies.  His group has developed a set of molecular imaging agents for neurography, the imaging of nerve tissue by means of molecular imaging, and has investigated several preclinical models in preparation to applying this technology to humans.

He also has a patient-centered program investigating the correlations between imaging and biological findings in patients with gliomas, in collaboration with Neurosurgery and Neuropathology, and involving advanced MR imaging directed biopsies correlated to state-of-the-art pathological and biological assessments of harvested patient brain tissues   He is also investigating the clinical uses of Dual Energy CT and Phase Sensitive MR in the characterization of cerebral lesions in a human imaging trial.

Research Interests

  • Molecular Imaging of novel gene and cell based therapies, particularly for Central Nervous System (CNS) conditions
  • Non-invasive mapping of therapeutic gene delivery
  • Assessment of therapeutic gene expression by imaging
  • Pharmacological manipulation of gene therapy vector distribution
  • Focused ultrasound for the disruption of the blood brain barrier
  • Assessment of PET agents for the delineation of brain tumors

Clinical Interests

Developing new imaging technologies and image guided therapies

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1482
Houston, TX 77030

Education & Training

Degree-Granting Education

1993 University of Pretoria, Faculty of Medicine, Pretoria, South Africa, MBChB, Cum Laude, Medicine

Postgraduate Training

1/1994-12/1994 Post-graduate degree: BSc Hons (cum laude), Physiology, University of Pretoria, Pretoria, South Africa, Advisor: Margaretha Viljoen, PhD

Board Certifications

2002 American Board of Radiology, Certificate of Additional Qualification in Neuroradiology, Recertification Date: 2022
2000 American Board of Radiology, Diagnostic Radiology (valid indefinite)


Administrative Appointments/Responsibilities

Head of Schellingerhout Lab, Department of Radiology, Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-present

Selected Publications

Peer-Reviewed Original Research Articles

1. LeRoux LG, Bredow S, Grosshans D, Schellingerhout D. Molecular imaging detects impairment in the retrograde axonal transport mechanism after radiation induced spinal cord injury. Mol Imaging Biol 16(4):504-10, Aug, 8/2014. e-Pub 1/2014. PMCID: PMC4085152.
2. Noh SM, Choi WJ, Kang BT, Jeong SW, Lee DK, Schellingerhout D, Yeo JS, Kim DE. Complementarity between (18)F-FDG PET/CT and Ultrasonography or Angiography in Carotid Plaque Characterization. J Clin Neurol 9(3):176-85, 7/2013. e-Pub 7/2013. PMCID: PMC3722469.
3. Shon SM, Choi Y, Kim JY, Lee DK, Park JY, Schellingerhout D, Kim DE. Photodynamic Therapy Using a Protease-Mediated Theranostic Agent Reduces Cathepsin-B Activity in Mouse Atheromata In Vivo. Arterioscler Thromb Vasc Biol 33(6):1360-5, 6/2013. e-Pub 3/2013. PMID: 23539220.
4. Kim DE, Kim JY, Sun IC,Schellingerhout D, Lee SK, Ahn CH, Kwon IC, Kim K. Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles. Ann Neurol. e-Pub 1/2013. PMID: 23495101.
5. Walker CM, Lee J, Ramirez MS, Schellingerhout D, Millward S, Bankson JA. A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-13C]-pyruvate. PLoS One 8(8):e71274, 2013. e-Pub 8/2013. PMCID: PMC3744565.
6. Shin IJ, Shon SM, Schellingerhout D, Park JY, Kim JY, Lee SK, Lee DK, Lee HW, Ahn BC, Kim K, Kwon IC, Kim DE. Characterization of partial ligation-induced carotid atherosclerosis model using dual-modality molecular imaging in ApoE knock-out mice. PLoS One 8(9):e73451, 2013. e-Pub 9/2013. PMCID: PMC3772018.
7. Raslan O, Debnam JM, Ketonen L, Kumar AJ, Schellingerhout D, Wang J. Stereoscopic visualization of diffusion tensor imaging data: A comparative survey of visualization techniques. Radiol Res Pract 2013:780916, 2013. e-Pub 10/2013. PMCID: PMC3819952.
8. Shawa H, Busaidy NL, Schellingerhout D, Habra MA. Unilateral renal artery stenosis with renal atrophy in a patient with metastatic papillary thyroid carcinoma treated with sorafenib. BMJ Case Rep 2013, 2013. e-Pub 5/2013. PMID: 23682094.
9. Hunter GJ, Schellingerhout D, Vu TH, Perrier ND, Hamberg LM. Accuracy of four-dimensional CT for the localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. Radiology 264(3):789-795, 9/2012. e-Pub 7/2012. PMID: 22798226.
10. Schellingerhout D, LeRoux LG, Hobbs BP, Bredow S. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One 7(9):e45776, 2012. e-Pub 9/2012. PMCID: PMC3447809.
11. Shon SM, Park JH, Nahrendorf M, Schellingerhout D, Kim JY, Kang BT, Jeong SW, Kim EJ, Ryu JH, Kim K, Kwon IC, Lee DK, Lee MM, Kim DE. Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. Atherosclerosis 216(1):67-73, 5/2011. e-Pub 2/2011. PMID: 21334624.
12. Ong SS, Bruner J, Schellingerhout D, Puduvalli VK. Papillary endothelial hyperplasia presenting as recurrent malignant glioma. J Neurooncol 102(3):491-498, 5/2011. e-Pub 8/2010. PMID: 20740304.
13. Raslan OA, Schellingerhout D, Fuller GN, Ketonen LM.. Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol 196(2):W187-193, 2/2011. PMID: 21257861.
14. Muzzafar S, Ketonen L, Weinberg JS, Schellingerhout D. Imaging and clinical features of an intra-axial brain stem schwannoma. AJNR Am J Neuroradiol 31(3):567-569, 3/2010. e-Pub 10/2009. PMID: 19833800.
15. Kim DE, Kim JY, Schellingerhout D, Kim EJ, Kim HK, Lee S, Kim K, Kwon IC, Shon SM, Jeong SW, Im SH, Lee DK, Lee MM, Kim GE. Protease imaging of human atheromata captures molecular information of atherosclerosis, complementing anatomic imaging. Arterioscler Thromb Vasc Biol 30(3):449-456, Feb 5, 3/2010. PMID: 20056915.
16. Muzzafar S, Rhines D, Bruner J, Schellingerhout D. Intradural extra skeletal Ewing tumor of the lumbar spine. Radiology Case Reports 5(4):1-5, 2010.
17. Schellingerhout D, Le Roux LG, Bredow S, Gelovani JG. Fluorescence imaging of fast retrograde axonal transport in living animals. Mol Imaging 8(6):319-329, 12/2009. PMID: 20003890.
18. Kim DE, Kim JY, Schellingerhout D, Shon SM, Jeong SW, Kim EJ, Kim WK. Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine. Mol Imaging 8(5):291-301, Sep-Oct, 9/2009. PMID: 19796606.
19. Debnam JM, Schellingerhout D, Kumar AJ, Ketonen L, Shah K, Hamberg LM, Hunter GJ. Multidetector CT-guided lumbar puncture in patients with cancer. Interv Neuroradiol 15(1):61-66, Mar, 3/2009. e-Pub 4/2009. PMCID: PMC3306150.
20. Debnam JM, Schellingerhout D. Focal cement accumulation in lytic metastatic lesions: a new sign in vertebroplasty? Interv Neuroradiol 14(4):465-470, Dec, 12/2008. e-Pub 1/2009. PMCID: PMC3313817.
21. Mortenson MM, Evans DB, Lee JE, Hunter GJ, Shellingerhout D, Vu T, Edeiken BS, Feng L, Perrier ND. Parathyroid exploration in the reoperative neck: improved preoperative localization with 4D-computed tomography. J Am Coll Surg 206(5):888-896, May, 5/2008. e-Pub 3/2008. PMID: 18471717.

Last updated: 8/17/2015