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Denise Renee Nebgen, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Gynecologic Oncology & Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Denise Nebgen is an Associate Professor in theDepartment of Gynecologic Oncology and Reproductive Medicine.  She is a native Texan who received her MD andPhD from Northwestern University.  As ageneral gynecologist, she provides comprehensive gynecologic care for women withcancer.  Her specialties include the treatmentof abnormal uterine bleeding, menopausal disorders, cervical dysplasia, ovariancysts, and hot flashes. She also treats vulvar disorders including graft disease, lichen planus, and sclerosis. Her principle interest is in the management of women at geneticallyhigh risk for gynecologic cancer, and she staffs the High Risk Ovarian CancerScreening clinic.  She is theprincipal investigator on a prophylactic salpingectomy and delayed oophorectomytrial in BRCA patients, and a co-investigator on multiple other quality of lifestudies.

Dr. Nebgen is board certified in Obstetrics and Gynecologyand is an active member of American College of Obstetrics and Gynecology, TexasAssociation of Obstetrics and Gynecology, and is on the Board of the HoustonGynecologic and Obstetric Society.  Herclinical excellence and caring have been recognized by being named for manyyears in Houston’s Top Doctors, Texas Super Doctors, and Marquis Who’s Who inAmerica.

Office Address

The University of Texas MD Anderson Cancer Center
Department of Gynecologic Oncology & Reproductive Medicine
1155 Pressler Street
Unit Number: 1362
Houston, TX 77030
Room Number: CPB6.3255
Fax: (713) 792-7586

Education & Training

Degree-Granting Education

1997 Northwestern University, Chicago, IL, MD, Medicine
1995 Northwestern University, Chicago, IL, PHD, Molecular Biology and Biochemistry
1988 The University of Texas Health Science Center at San Antonio, San Antonio, TX, DDS, Dentistry

Postgraduate Training

6/1997-6/2001 Internship and Residency, Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, Dr. Amy Young
6/1989-6/1990 Internship, Oral and Maxillofacial Surgery, University of Chicago, Chicago, IL
6/1988-6/1989 Fellowship, Oral and Maxillofacial Surgery, Baylor College of Dentistry, Dallas, TX

Board Certifications

2004 American Board of Obstetrics and Gynecology


Institutional Committee Activities

Member, Psychological, Behavioral, and Health Services Research Committee, 10/2013-present
Member, Prevention, HSR, QI and Survivorship Research Program, 10/2013-present

Honors and Awards

2011-present Texas Super Doctors
2010-present Marquis Who's Who in American Women
2010-present Marquis Who's Who in Science and Industry
2010-present Marquis Who's Who in the World
2009-present Marquis Who's Who in America
1993 Oral and Maxillofacial Surgery Foundation Research Award
1992 American Association Dental Research (AADR) Chicago, Young Investigators Award
1991-1995 Northwestern University, Oral Biology Grant, National Institute of Health
1991 University of Chicago Surgical Training Grant, National Institute of Health
1988 Dental College Dean's List UTHSC-SA
1988 Quintessence Clinical Achievement in Restorative Dentistry Award

Professional Memberships

American Association of Gynecologic Laparoscopists
Member, 2009-present
American College of Obstetrics and Gynecology
Member, 1997-present
Member, 7/2013-present
Harris County Medical Society, Houston, TX
Member, 2001-present
Texas Association of Obstetrics and Gynecology, TX
Member, 2001-present
Texas Medical Association, TX
Member, 2001-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Streff H, Profato J, Ye Y, Nebgen D, Peterson SK,Singletary C, Arun BK, Litton JK. Cancer Incidence in First and Second Degree Relatives of BRCA1 and BRCA2 Mutation Carriers. The Oncologist. In Press.
2. Nebgen DR, Doody KJ. Should salpingectomy be standard of care at time of bilateral tubal ligation? Contemporary OB/GYN, 4/2015.
3. Mersch J, Jackson MA, Park M, Nebgen D, Peterson SK, Singletary C, Arun BK, Litton JK. Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. Cancer. e-Pub 9/15/2014. PMID: 25224030.
4. Nebgen DR, Lu KH, Rimes S, Keeler E, Broaddus R, Munsell MF, Lynch PM. Combined colonoscopy and endometrial biopsy cancer screening results in women with Lynch syndrome. Gynecologic Oncology(135):85-89, 2014. PMID: 25149916.
5. Bercaw-Pratt JL, Santos XM, Sanchez J, Ayensu-Coker L, Nebgen DR, Dietrich JE. The incidence, attitudes and practices of the removal of pubic hair as a body modification. J Pediatr Adolesc Gynecol 25(1):12-4, 2/2012. e-Pub 11/16/2011. PMID: 22088314.
6. Gee PJ, Nebgen D, Stewart EA. Magnetic Resonance Guided Focused Ultrasound Surgery (MRg/fus) of Uterine Fibroids in African American Patients. J Minim Invasive Gynecol, 2007.
7. Nebgen DR, Inoue H, Sabsay B, Wei K, Ho CS, Veis A. Identification of the chondrogenic-inducing activity from bovine dentin (bCIA) as a low-molecular-mass amelogenin polypeptide. J Dent Res 78(9):1484-94, 9/1999. PMID: 10512382.
8. Inoue H, Nebgen D, Veis A. Changes in phenotypic gene expression in rat mandibular condylar cartilage cells during long-term culture. J Bone Miner Res 10(11):1691-7, 11/1995. PMID: 8592945.
9. DiPietro LA, Nebgen DR, Polverini PJ. Downregulation of endothelial cell thrombospondin 1 enhances in vitro angiogenesis. J Vasc Res 31(3):178-85, May-Jun, 5/1994. PMID: 7511943.
10. Nebgen D, Wood RS, Shapiro RD. Management of a mandibular fracture in a patient with cleidocranial dysplasia: report of a case and review of the literature. J Oral Maxillofac Surg 49(4):405-9, 4/1991. PMID: 2005496.

Invited Articles

1. Bradford A, Nebgen D. Is estrogen therapy safe for the management of sexual dysfunction in female cancer survivors of a hormone-responsive cancer? Healio HemOnc Today, 7/2015.
2. Ronda Wendler/Denise Nebgen. Removing fallopian tubes may lower ovarian cancer risk. UT MD Anderson Conquest, 2015.


1. Bradford A, Nebgen D, Keeler E, Milbourne A. A comprehensive proram to meet the sexual health needs of women with cancer. Poster - Proceedings In: 7th Biennial Cancer Survivorship Research Conference, Atlanta, GA, 6/2014.
2. Nebgen DR, Hartman C, Rhodes HR, Woodard TL, Lu KH. Abnormal uterine bleeding as the presenting symptom of hematopoietic cancer. Proceedings IN: ACOG Annual Clinical Meeting, 4/2014.
3. Woodard T, Kovanci E, Gibbons WE, Nebgen D, Lu K. Fertility services for women with gynecologic cancers: A new model for provision of services. SGO, 3/2014.
4. Nebgen DR, Lynch PM, Broaddus R, Lu KH. Combined colon and endometrial cancer screening in women with HNPCC/Lynch Syndrome. The International Society for Gastrointestinal Hereditary Tumours, 2013.
5. Nebgen DR, Sun C,. Hydroxyzine for the Management of Hot Flashes in Breast Cancer Patients. MDA Cancer Survivorship Research Retreat, 1/2012.
6. Vo HQ, Hobday CD, Nebgen D, Yu N, Li K. Phase 4 Clinical MRgFUS Treatment of Large Uterine Fibroids Using the Insightec ExAblate 2000. Third International Symposium on Focused Ultrasound, 2012.
7. Vo HQ, Hobday C, Nebgen D, Yu N, Li K. Phase 3 Clinical MRgFUS treatment of large uterine fibroids using the Insightec ExAblate 2000. The Methodist Perspective, 2011.
8. Nebgen D, Gee P, Akin MD. Image characterization of fibroids to improve magnetic resonance guided focused ultrasound (MRgFUS) treatment outcomes. AAGL, 11/2009.
9. Gee PJ, Tempany C, leBlang S, Nebgen D, Curtis P, Stewart EA. Magnetic resonance guided focused ultrasound surgery (MRgFUS) of uterine fibroid in African American patients. 9th Annual Advanced Workshop on Gynecologic Laparoscopic Anatomy and Minimally Invasive Surgery Including TVT and TOT - AAGL, 5/2009.
10. Rowe G, Nebgen DR. Successful pregnancy after magnetic resonance imaging guided focused ultrasound (MRgFUS) treatment of uterine leiomyoma. Ultrasound in Obstetrics & Gynecology 32(3):415-416, 8/2008.
11. Phyllis Gee, MD, Claire Tempany, MD, Susan LeBlang, MD, Denise Nebgen, MD, PhD, Paul Curtis, MD, Elizabeth Stewart. MD. Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) of Uterine Fibroids in African Patients. 9th Annual AAGL Advanced Workshop, 5/2007.

Last updated: 3/18/2016