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Dimitrios P. Kontoyiannis, M.D., M.S., Sc.D., F.A.C.P., F.I.D.S.A.

Present Title & Affiliation

Primary Appointment

Frances King Black Endowed Professor, Department of Infectious Diseases, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Head, Division of Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1998 University of Crete, Crete, Greece, DSc, Medical Thesis: Transposon mutagenesis to study azole resistance in S. cerevisiae
1997 Harvard Medical School, Boston, MA, MS, Medical Sciences (MSc)
1987 National and Kapodistrian University of Athens, Athens, Greece, MD, Medical Science

Selected Publications

Peer-Reviewed Original Research Articles

1. Diaz L, Kontoyiannis DP, Panesso D, Albert N, Singh KV, Tran TT, Munita JM, Murray BE, Arias CA. Dissecting the Mechanisms of Linezolid Resistance in a Drosophila melanogaster Infection Model of Staphylococcus aureus. J Infect Dis. e-Pub 4/2013. PMID: 23547139.
2. Lewis RE, Cahyame-Zuniga L, Leventakos K, Chamilos G, Ben-Ami R, Tamboli P, Tarrand J, Bodey GP, Luna M, Kontoyiannis DP. Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: a 20-year autopsy study. Mycoses. e-Pub 4/2013. PMID: 23551865.
3. Ben-Ami R, Albert ND, Lewis RE, Kontoyiannis DP. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. J Infect Dis 207(7):1066-74, 4/2013. e-Pub 1/2013. PMCID: PMC3583270.
4. Lewis RE, Ben-Ami R, Best L, Albert N, Walsh TJ, Kontoyiannis DP. Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. J Infect Dis 207(5):834-41, 3/2013. e-Pub 12/2012. PMCID: PMC3563310.
5. Farmakiotis D, Tverdek FP, Kontoyiannis DP. The safety of amphotericin B lipid complex in patients with prior severe intolerance to liposomal amphotericin B. Clin Infect Dis 56(5):701-3, 3/2013. e-Pub 11/2012. PMID: 23166189.
6. Baddley JW, Andes DR, Marr KA, Kauffman CA, Kontoyiannis DP, Ito JI, Schuster MG, Brizendine KD, Patterson TF, Lyon GM, Boeckh M, Oster RA, Chiller T, Pappas PG. Antifungal therapy and length of hospitalization in transplant patients with invasive aspergillosis. Med Mycol 51(2):128-35, 2/2013. e-Pub 6/2012. PMID: 22680976.
7. Ben-Ami R, Watson CC, Lewis RE, Albert ND, Arias CA, Raad II, Kontoyiannis DP. Drosophila melanogaster as a model to explore the effects of methicillin-resistant Staphylococcus aureus strain type on virulence and response to linezolid treatment. Microb Pathog 55:16-20, 2/2013. e-Pub 12/2012. PMID: 23232438.
8. Kontoyiannis DP, Georgiadou SP, Wierda WG, Wright S, Albert ND, Ferrajoli A, Keating M, Lewis RE. Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia. Leuk Lymphoma. e-Pub 2/2013. PMID: 23163595.
9. McGrath DM, Barbu EM, Driessen WH, Lasco TM, Tarrand JJ, Okhuysen PC, Kontoyiannis DP, Sidman RL, Pasqualini R, Arap W. Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic. Proc Natl Acad Sci U S A 110(9):3477-82, 2/2013. e-Pub 1/2013. PMCID: PMC3587187.
10. Lewis RE, Albert NP, Liao G, Wang W, Prince RA, Kontoyiannis DP. High-dose induction liposomal amphotericin B followed by de-escalation is effective in experimental Aspergillus terreus pneumonia. J Antimicrob Chemother. e-Pub 1/2013. PMID: 23349440.
11. Petraitis V, Petraitiene R, Antachopoulos C, Hughes JE, Cotton MP, Kasai M, Harrington S, Gamaletsou MN, Bacher JD, Kontoyiannis DP, Roilides E, Walsh TJ. Increased virulence of Cunninghamella bertholletiae in experimental pulmonary mucormycosis: correlation with circulating molecular biomarkers, sporangiospore germination and hyphal metabolism. Med Mycol 51(1):72-82, 1/2013. e-Pub 6/2012. PMID: 22686246.
12. Mahale P, Kontoyiannis DP, Chemaly RF, Jiang Y, Hwang JP, Davila M, Torres HA. Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients. J Hepatol 57(6):1177-85, 12/2012. e-Pub 8/2012. PMID: 22871500.
13. Gamaletsou MN, Sipsas NV, Kontoyiannis DP, Tsiakalos A, Kontos AN, Stefanou I, Kordossis T. Successful salvage therapy of refractory HIV-related cryptococcal meningitis with the combination of liposomal amphotericin B, voriconazole, and recombinant interferon-γ. Diagn Microbiol Infect Dis 74(4):409-11, 12/2012. e-Pub 9/2012. PMID: 22975207.
14. Gamaletsou MN, Kontoyiannis DP, Sipsas NV, Moriyama B, Alexander E, Roilides E, Brause B, Walsh TJ. Candida osteomyelitis: analysis of 207 pediatric and adult cases (1970-2011). Clin Infect Dis 55(10):1338-51, 11/2012. e-Pub 8/2012. PMID: 22911646.
15. Georgiadou SP, Tarrand J, Sipsas NV, Kontoyiannis DP. Candiduria in haematologic malignancy patients without a urinary catheter: nothing more than a frailty marker? Mycoses. e-Pub 11/2012. PMID: 23170870.
16. Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M. Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood 120(18):3699-707, 11/2012. e-Pub 8/2012. PMCID: PMC3488884.
17. Georgiadou SP, Kontoyiannis DP. Concurrent lung infections in patients with hematological malignancies and invasive pulmonary aspergillosis: how firm is the Aspergillus diagnosis? J Infect 65(3):262-8, 9/2012. e-Pub 5/2012. PMID: 22580034.
18. Spellberg B, Kontoyiannis DP, Fredricks D, Morris MI, Perfect JR, Chin-Hong PV, Ibrahim AS, Brass EP. Risk factors for mortality in patients with mucormycosis. Med Mycol 50(6):611-8, 8/2012. e-Pub 3/2012. PMID: 22435877.
19. Cahuayme-Zuniga L, Lewis RE, Mulanoich VE, Kontoyiannis DP. Weekly liposomal amphotericin B as secondary prophylaxis for invasive fungal infections in patients with hematological malignancies. Med Mycol 50(5):543-8, 7/2012. e-Pub 11/2011. PMID: 22103347.
20. Spellberg B, Ibrahim AS, Chin-Hong PV, Kontoyiannis DP, Morris MI, Perfect JR, Fredricks D, Brass EP. The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. J Antimicrob Chemother 67(3):715-22, 3/2012. e-Pub 9/2011. PMCID: PMC3383100.
21. Pongas G, Hamilos G, Rolston KV, Kontoyiannis DP. Formal adult infectious disease specialist consultations in the outpatient setting at a comprehensive cancer center (1998-2008): Diverse and impactful. Support Care Cancer 20(2):261-5, 2/2012. e-Pub 12/2010. PMID: 21191800.
22. Chitasombat MN, Kofteridis DP, Jiang Y, Tarrand J, Lewis RE, Kontoyiannis DP. Rare opportunistic (non-Candida, non-Cryptococcus) yeast bloodstream infections in patients with cancer. J Infect 64(1):68-75, 1/2012. e-Pub 11/2011. PMID: 22101079.

Invited Articles

1. Georgiadou SP, Kontoyiannis DP. The impact of azole resistance on aspergillosis guidelines. Ann N Y Acad Sci 1272:15-22, 12/2012. PMID: 23231710.

Editorials

1. Kontoyiannis DP. Preventing fungal disease in chronically immunosuppressed outpatients: time for action? Ann Intern Med 158(7):555-6, 4/2013. PMID: 23546567.
2. Pappas PG, Kontoyiannis DP, Perfect JR, Chiller TM. Real-Time Treatment Guidelines: Considerations during the Exserohilum rostratum Outbreak in the United States. Antimicrob Agents Chemother 57(4):1573-6, 4/2013. e-Pub 2/2013. PMCID: PMC3623335.

Last updated: 4/7/2014