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Dimitrios P. Kontoyiannis, M.D., M.S., Sc.D., F.A.C.P., F.I.D.S.A.

Present Title & Affiliation

Primary Appointment

Frances King Black Endowed Professor, Department of Infectious Diseases, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Head Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1998 University of Crete, Crete, Greece, DSc, Medical Thesis: Transposon mutagenesis to study azole resistance in S. cerevisiae
1997 Harvard Medical School, Boston, MA, MS, Medical Sciences (MSc)
1987 National and Kapodistrian University of Athens, Athens, Greece, MD, Medical Science

Selected Publications

Peer-Reviewed Original Research Articles

1. Galloway-Peña JR, Smith DP, Sahasrabhojane P, Ajami NJ, Wadsworth WD, Daver NG, Chemaly RF, Marsh L, Ghantoji SS, Pemmaraju N, Garcia-Manero G, Rezvani K, Alousi AM, Wargo JA, Shpall EJ, Futreal PA, Guindani M, Petrosino JF, Kontoyiannis DP, Shelburne SA. The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia. Cancer. e-Pub 5/2016. PMID: 27142181.
2. Kyvernitakis A, Torres HA, Jiang Y, Chamilos G, Lewis RE, Kontoyiannis DP. Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: a propensity score analysis. Clin Microbiol Infect. e-Pub 4/2016. PMID: 27085727.
3. Shelburne SA, Ajami NJ, Chibucos MC, Beird HC, Tarrand J, Galloway-Peña J, Albert N, Chemaly RF, Ghantoji SS, Marsh L, Pemmaraju N, Andreeff M, Shpall EJ, Wargo JA, Rezvani K, Alousi A, Bruno VM, Futreal PA, Petrosino JF, Kontoyiannis DP. Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis. PLoS One 10(11):e0139851, 2015. e-Pub 11/2015. PMCID: PMC4640583.
4. Farmakiotis D, Tarrand JJ, Kontoyiannis DP. Drug-Resistant Candida glabrata Infection in Cancer Patients. Emerg Infect Dis 20(11):1833-40, 11/2014. PMCID: PMC4214312.
5. Thompson GR, Albert N, Hodge G, Wilson MD, Sykes JE, Bays DJ, Firacative C, Meyer W, Kontoyiannis DP. Phenotypic Differences of Cryptococcus Molecular Types: implications for virulence in a Drosophila model of infection. Infect Immun 82(7):3058-3065, 7/2014. e-Pub 5/2014. PMCID: PMC4097627.
6. Kontoyiannis DP, Georgiadou SP, Wierda WG, Wright S, Albert ND, Ferrajoli A, Keating M, Lewis RE. Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia. Leuk Lymphoma 54(8):1730-3, 8/2013. e-Pub 2/2013. PMCID: PMC3858983.
7. Ben-Ami R, Albert ND, Lewis RE, Kontoyiannis DP. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. J Infect Dis 207(7):1066-74, 4/2013. e-Pub 1/2013. PMCID: PMC3583270.
8. Lewis RE, Ben-Ami R, Best L, Albert N, Walsh TJ, Kontoyiannis DP. Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. J Infect Dis 207(5):834-41, 3/2013. e-Pub 12/2012. PMCID: PMC3563310.
9. Ben-Ami R, Lewis RE, Leventakos K, Latgé JP, Kontoyiannis DP. A Cutaneous model of invasive aspergillosis. Antimicrob Agents Chemother 54(5):1848-54, 5/2010. e-Pub 2/2010. PMCID: PMC2863682.
10. Ben-Ami R, Varga V, Lewis RE, May GS, Nierman WC, Kontoyiannis DP. Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant. Virulence 1(3):164-73, May-Jun, 5/2010. PMCID: PMC3265789.
11. Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 50(8):1091-100, 4/2010. PMID: 20218877.
12. Ben-Ami R, Lewis RE, Tarrand J, Leventakos K, Kontoyiannis DP. Antifungal activity of colistin against Mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection. Antimicrob Agents Chemother 54(1):484-90, 1/2010. e-Pub 10/2009. PMCID: PMC2798530.
13. Lamaris GA, Ben-Ami R, Lewis RE, Chamilos G, Samonis G, Kontoyiannis DP. Increased virulence of Zygomycetes organisms following exposure to voriconazole: a study involving fly and murine models of zygomycosis. J Infect Dis 199(9):1399-406, 5/2009. PMID: 19358672.
14. Lamaris GA, Lewis RE, Chamilos G, May GS, Safdar A, Walsh TJ, Raad II, Kontoyiannis DP. Caspofungin-mediated beta-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus hyphae. J Infect Dis 198(2):186-92, 2008. PMID: 18500936.
15. Lewis RE, Albert ND, Kontoyiannis DP. Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis. J Antimicrob Chemother 61(5):1140-4, 2008. PMID: 18305201.
16. Lewis RE, Liao G, Hou J, Chamilos G, Prince RA, Kontoyiannis DP. A comparative analysis of amphotericin B lipid complex and liposomal amphotericin B kinetics of lung accumulation and fungal clearance in a murine model of acute invasive pulmonary aspergillosis. Antimicrob Agents Chemother 51(4):1253-8, 2007. PMID: 17261624.
17. Chamilos G, Luna M, Lewis RE, Bodey GP, Chemaly R, Tarrand JJ, Safdar A, Raad II, Kontoyiannis DP. Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003). Haematologica 91(7):986-9, 2006. PMID: 16757415.
18. Lionakis MS, Chamilos G, Lewis RE, Wiederhold NP, Raad II, Samonis G, Kontoyiannis DP. Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis. Antimicrob Agents Chemother 50(1):294-7, 2006. PMID: 16377700.
19. Lewis RE, Wiederhold NP, Lionakis MS, Prince RA,Kontoyiannis DP. Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center. J Clin Microbiol 43(12):6120-2, 12/2005. PMCID: PMC1317213.
20. Lionakis MS, Lahdenranta J, Sun J, Liu W, Lewis RE, Albert ND, Pasqualini R, Arap W, Kontoyiannis DP. Development of a ligand-directed approach to study the pathogenesis of invasive aspergillosis. Infect Immun 73(11):7747-58, 2005. PMID: 16239579.
21. Lionakis MS, Lewis RE, May GS, Wiederhold NP, Albert ND, Halder G, Kontoyiannis DP. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J Infect Dis 191(7):1188-95, 2005. PMID: 15747256.
22. Wiederhold NP, Kontoyiannis DP, Chi J, Prince RA, Tam VH, Lewis RE. Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity. J Infect Dis 190(8):1464-71, 2004. PMID: 15378439.

Invited Articles

1. McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP, Walsh TJ. Mold Infections of the Central Nervous System. N Engl J Med 371(2):150-160, 7/2014. PMID: 25006721.
2. Georgiadou SP, Kontoyiannis DP. The impact of azole resistance on aspergillosis guidelines. Ann N Y Acad Sci 1272:15-22, 12/2012. PMID: 23231710.

Editorials

1. Kontoyiannis DP. Preventing fungal disease in chronically immunosuppressed outpatients: time for action? Ann Intern Med 158(7):555-6, 4/2013. PMID: 23546567.
2. Pappas PG, Kontoyiannis DP, Perfect JR, Chiller TM. Real-Time Treatment Guidelines: Considerations during the Exserohilum rostratum Outbreak in the United States. Antimicrob Agents Chemother 57(4):1573-6, 4/2013. e-Pub 2/2013. PMCID: PMC3623335.

Last updated: 7/25/2016