Dimpy Koul, Ph.D.

Peer-Reviewed Articles

1. Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D. A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem Cells 32(1):301-12, 2014. PMID: 24038660.
2. Kim YW, Koul D, Kim SH, Lucio-Eterovic K, Freire PR, Yao J, Wang J, Almeida JS, Aldape K, and Yung WK. Identification of Prognostic Gene Signatures of Glioblastoma: A Study Based on Data Analysis. Neuro-Oncology, 2013. PMID: 23502430.
3. Zheng S, Fu J, Vegesna R, Mao Y, Heathcock LE, Torres-Garcia W, Ezhilarasan R, Wang S, McKenna A, Chin L, Brennan CW, Yung WK, Weinstein JN, Aldape KD, Sulman EP, Chen K, Koul D, Verhaak RG. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev 27(13):1462-72, 2013. e-Pub 2013. PMID: 23796897.
4. Koul D, Fu J, Shen R, LaFortune TA, Wang S, Tiao N, Kim YW, Liu JL, Ramnarian D, Yuan Y, Garcia-Echevrria C, Maira SM, Yung WK. Antitumor activity of NVP-BKM120- a selective pan class 1 PI3 Kinase inhibitor showed differential forms of cell death based on P53 status of glioma cells. Clin Cancer Res 18(1):184-95, 2012. e-Pub 2011. PMID: 22065080.
5. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell 20(3):384-99, 2011. PMID: 21907928.
6. Guan S, Shen R, Lafortune T, Tiao N, Houghton P, Yung WK, Koul D. Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy. Neuro Oncol 13(7):748-58, 2011. e-Pub 2011. PMID: 21653596.
7. Kim YW, Liu TJ, Koul D, Tiao N, Feroze AH, Wang J, Powis G, Yung WK. Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. Neuro Oncol 13(4):367-75, 2011. PMID: 21430111.
8. Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. Int J Cancer 128(4):787-96, 2011. PMID: 20473884.
9. Koul D, Shen R, Kim YW, Kondo Y, Lu Y, Bankson J, Ronen SM, Kirkpatrick DL, Powis G, Yung WK. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol 12(6):559-69, 2010. e-Pub 2010. PMID: 20156803.
10. Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WKA. NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol Cancer Ther 8(8):2204-10, 2009. e-Pub 2009. PMID: 19671762.
11. Verma A, Guha S, Wang H, Fok JY, Koul D, Abbruzzese J, Mehta K. Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res 14(7):1997-2005, 2008. PMID: 18381937.
12. Freire P, Yung WK, Aldape KD, Bogler O, Koul D, Coombes K, Mills GB, Vasconcelos AT, Almeida JS. Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS Biol 3(12):e4076, 2008. e-Pub 2008. PMID: 19115005.
13. Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway. Mol Cell Biochem 300(1-2):77-87, 2007. PMID: 17235455.
14. Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochem Biophys Res Commun 350(2):463-71, 2006. e-Pub 2006. PMID: 17011514.
15. Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. Mol Cancer Ther 5(3):637-44, 2006. PMID: 16546978.
16. Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther 4(11):1681-8, 2005. PMID: 16275989.
17. Nigro JM, Misra A, Zhang L, Smirnov I, Colman H, Griffin C, Ozburn N, Chen M, Pan E, Koul D, Yung WK, Feuerstein BG, Aldape KD. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res 65(5):1678-86, 2005. PMID: 15753362.
18. Unni E, Koul D, Yung WK, Sinha R. Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro. Breast Cancer Res 7(5):R699-707, 2005. PMID: 16168115.
19. Mehta K, Fok J, Miller FR, Koul D, Sahin AA. Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer. Clin Cancer Res 10(23):8068-76, 2004. PMID: 15585642.
20. Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res 64(20):7361-9, 2004. PMID: 15492257.
21. Shishodia S, Koul D, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 173(3):2011-22, 2004. PMID: 15265936.
22. Cerrato JA, Khan T, Koul D, Lang FF, Conrad CA, Yung WK, Liu TJ. Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas. Int J Oncol 24(2):409-17, 2004. PMID: 14719118.
23. Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 278(41):40057-66, 2003. e-Pub 2003. PMID: 12869565.
24. Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK. MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Int J Oncol 21(3):469-75, 2002. PMID: 12168088.
25. Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK. Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene 21(15):2357-64, 2002. PMID: 11948419.
26. Sheng X, Koul D, Liu JL, Liu TJ, Yung WK. Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region. Biochem Biophys Res Commun 292(2):422-6, 2002. PMID: 11906179.
27. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20(46):6669-78, 2001. PMID: 11709701.
28. Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61(18):6693-7, 2001. PMID: 11559537.
29. Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem 276(14):11402-8, 2001. PMID: 11278366.
30. Tanaka M, Koul D, Davies MA, Liebert M, Steck PA, Grossman HB. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene 19(47):5406-12, 2000. PMID: 11103942.
31. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59(11):2551-6, 1999. PMID: 10363971.
32. Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, Hess KR, Myers JN, Hong YK, Yung WK, Steck PA. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res 59(8):1820-4, 1999. PMID: 10213484.
33. Steck PA, Lin H, Langford LA, Jasser SA, Koul D, Yung WK, Pershouse MA. Functional and molecular analyses of 10q deletions in human gliomas. Genes, Chromosomes and Cancer 24(2):135-43, 1999. PMID: 9885980.
34. Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 58(23):5285-90, 1998. PMID: 9850049.
35. Koul D, Obeyesekere NU, Gutterman JU, Mills GB, Choubey D. p202 self-associates through a sequence conserved among the members of the 200-family proteins. FEBS Lett 438(1-2):21-4, 1998. PMID: 9821952.
36. Koul D, Lapushin R, Xu HJ, Mills GB, Gutterman JU, Choubey D. p202 prevents apoptosis in murine AKR-2B fibroblasts. Biochem Biophys Res Commun 247(2):379-82, 1998. PMID: 9642135.
37. Sehgal S, Koul D, Verma S. Effect of immunization with human SP-10 in male rodents. Am J Reprod Immunol 36(3):167-74, 1996. PMID: 8874713.
38. Siddiqui M, Kumar R, Koul D, Spiegelhalder B, Preussmann R. Salivary nitrate and nitrite concentrations from sample population of children and adults in high risk area of esophageal and gastric cancers in Kashmir, India. Cancer Lett 64(2):133-6, 1992.

Invited Articles

1. Koul D. PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7(9):1321-1325, 2008. e-Pub 2008. PMID: 18836294.

Abstracts

1. Fu J, Koul D, Yao J, Wang S, Gumin J, Shen R, Vaillant B, Colman H, Lang F, Aldape K, Yung WK. Molecular and lineage analysis of glioblastoma stem cells identifies clinically relevant models of glioblatoma. 102nd Annual Meeting of the American Association for Cancer Research, Orlando, Florida. April 2-6, 2011, 2011.
2. Koul D, Shen R, LaFortune T, and Yung WK. NVP-BKM120: a selective pan-PI3 Kinase inhibitor induces G2/M arrest in glioma cell lines via FOXO3a and GADD45a loop. 101st Annual Meeting of the American Association for Cancer Research, Washington, DC, April 17-21, 2010, 2010.
3. Guan S, Yung WKA, Koul D. Methionine aminopeptidase-2 interferes with VHL to regulate VEGF transcription through HIF-1 alpha: role for angiogenesis inhibition in glioma. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR;, 2009. e-Pub 2009.
4. Kim YW, Koul D, Kim SH, Almeida JS, Bogler O, Aldape K, Yung WKA.. Novel gene set identification and pathway specific survival patterns using gene expression profiling of human glioblastoma: A study based on TCGA data analysis. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR;, 2009.
5. Kim YW, Tiao N, Lafortune T, Liu T-J, Powis G, Yung WKA, Koul D. Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening. 99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA, 2008.
6. Koul D, Shen R, Edge J, Henry V, Webb D, Bankson J, Ronen S, Powis G, Kirkpatrick DL, Yung WKA. Cellular and in vivo activity of a new PI3K inhibitor-PX866 for treatment of human glioblastoma. 99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA, 2008.
7. Koul D, Shen R, Edge J, Iwado E, Kondo Y, Liu TJ, Powis G, Kirkpatrick DL, Yung WK.. Targeting Phosphatidylinositol 3-Kinase (P13K) Pathway in Human Glioblastoma with PX866: a small molecule P13K inhibitor. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA, 2007. e-Pub 2007.
8. Verma A, Guha S, Koul D, Wang H, Mehta K. Regulation of tumor suppressor protein PTEN by tissue transglutaminase: prognostic significance in pancreatic cancer. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA, 2007. e-Pub 2007.
9. Koul D, Shen R, Edge J, Iwado E, Knondo Y, Liu TJ, Powis G, Kirkpatrick L, Yung WK.. Phosphatidylinositol 3-Kinase (P13K) pathway- a therapeutic target for human glioblastoma. Neuro-oncol 8(4):414, 2006.
10. Koul D, Bergh S, Shen R, Yung WKA. Targeting integrin linked kinase (ILK) pathway in human glioblastoma. Neuro-oncol 6(4):332, 2004.
11. Koul D, Shen R, Bergh S, Yung WKA. Characterization of PTEN associated proteins. Proc Amer Assoc Cancer Res 45:815, 2004.
12. Koul D, Bergh S, Shen R, Yung WKA. Targeting ILK Pathway in Human Glioblastoma. Proc Amer Assoc Cancer Res 45:1200, 2004.
13. Koul D, Shen R, Bergh S, Yung WKA. Characterization of PTEN associated proteins. Neuro-oncol 5(4):279-360, 2003.
14. Koul D, Bergh S, Shen R, Yung WKA. Targeting PTEN/PI3K pathway in human glioblastoma. Neuro-oncol 5(4):290-291, 2003.
15. Koul D, Parthasarathy R, Shen R, Liu TJ, Yung WKA. PTEN tumor suppressor gene inhibits matrix metalloproteinase-2 gene expression and invasion in human glioma cells. Neuro-oncol 4(4):338, 2002.
16. Liu JL, Sheng X, Koul D, Yung WKA. Cell cycle-dependent subcellular localization of PTEN/MMAC tumor suppressor is regulated by PI3k signaling cascades. Neuro-oncol 4(4):315, 2002.
17. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. MMAC/PTEN tumor suppressor gene inhibits matrix metalloproteinase-2 gene expression and invasion in human glioma cells. 93rd Annual meeting of American Association for Cancer Research, San Fransisco, CA, 2002.
18. Koul D, Yao Y, Abbruzzese JL, Yung WKA, Reddy SA. MMAC/PTEN tumor suppressor inhibits cytokine-induced NFkB activation–Evidence for a novel mechanism. 92nd Annual meeting of American Association for Cancer Research, New Orleans, LA, 2001.
19. Gomez-Manzano C, Mitilianga P, Koul D, Yung WKA. E2F transcriptionally upregulates BCL- 2. Neuro-oncol 2(4):265, 2000.
20. Gomez-Manzano C, Fueyo J, Glass T, Koul D, Lee HY, Shi YX, Liu TJ, Yung WKA. MMAC/PTEN downregulates VEGF in gliomas. Neuro-oncol 2(4):265, 2000.
21. Koul D, Yao Y, Reddy SAG, Abbruzzese JL, Yung WKA. Regulation of NFkB and Ap-1 activation through MMAC/PTEN. Neuro-oncol 2(4):275, 2000.
22. Koul D, Jasser SA, Davies MA, Liu JL, Lu Y, Reddy SAG, Mills GB, Yung WKA, Steck PA. Motif analysis of Tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and signal transduction and reveals alternative mechanisms of Akt phosphorylation. 91st AACR Annual Meeting-- Apr 14-18, 2000; San Francisco, CA, 2000.
23. Koul D, Steck PA. Functional roles of MMAC/PTEN. 90th AACR Annual Meeting-- Apr 10-14, 1999; Philadelphia, PA (Invited Speaker), 1999.
24. Koul D. Regulatory functions of MMAC/PTEN tumor suppressor gene. Fourth Annual Meeting of Society for Neuro-Oncology; Scottsdale, AZ, 1999.
25. Koul D, Sehgal S, Verma S. Anti SP-10 antibodies do not interfere with spermatogenesis. Ninth International Congress of Immunology; San Fransisco, CA, 1995.
26. Koul D, Sehgal S, Verma S. Effect of immunization with human SP-10 in male rodents. Sixth International Congress of Reproductive Immunology, Washington, DC, 1995.
27. Koul D, Verma S, Sehgal S. Effect of immunization with human SP-10 in male rodents. Indian Immunology Society; Chandigarh, India, 1994.
28. Sehgal S, Koul D, Vasishta K, Herr J. Serum antibodies to recombinant human intra-acrosomal antigen SP-10 in infertile couples. Fourteenth Annual Meeting of the American Society for Reproductive Immunology (ASRI); Philadelphia, PA, 1994.
29. Koul D. Status of human SP-10 as a candidate contraceptive vaccine. Indian Immunology Society; Chandigarh, India, 1994.
30. Koul D, Vasishta K, Sehgal S. Identification and characterization of a 26 Kd immunodominant antigen of human sperm membrane. Indian Immunology Society; Bhopal, India, 1993.
31. Sehgal S, Koul D, Singh G, Wright RM, Herr J. Cross-reactivity of SP-10 with bull spermatozoa. International Congress of Reproductive Immunology; Rome, Italy, 1992.
32. Sehgal S, Sinha R, Koul D, Khullar N. Diagnostic Assay for Kalazar. 8th International Congress of Immunology; Budapest, Hungary, 1992.
33. Sehgal S, Koul D, Gupta SK, Gupta R, Singh G, Dhall K. Comparative evaluation of antisperm antibodies in infertile couples. Indian Immunology Society; Delhi, India, 1991.
34. Sehgal S, Singh G, Koul D, Malhotra S. Use of flowcytometry in evaluation of sperm bound antibodies. Indian Immunology Society; Delhi, India, 1991.

Book Chapters

1. Koul D, Davies MA, Steck PA, Yung WK. MMAC/PTEN: The Progression Tumor Suppressor Gene. In: Recent Research Developments in Cancer. Part II. Transworld research network: Trivandrum, India, 271-281, 2000.

Books (edited and written)

1. Steck PA, Yung WK, Davies MA, Koul D, Jasser, S. Functional identification and characterization of MMAC/PTEN: Involvement in malignant progression. Current Options for the Human Genome Project, 2000.