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Donna Saltzburg Zhukovsky, MD, FACP, FAAHPM

Present Title & Affiliation

Primary Appointment

Professor, Department of Palliative Care and Rehabilitation Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1982 McGill University, School of Medicine, Montreal, Canada, MD-CM, Medicine
1978 McGill University, Montreal, Canada, BSc, First Class Honors, Biology, with Specialization in Human Genetics

Postgraduate Training

1987-1989 Clinical Fellowship, Neurology-Cancer Pain, Memorial Sloan-Kettering Cancer Center, New York, NY, Dr. Kathleen M. Foley
1985-1987 Clinical Fellowship, Neoplastic Diseases, Mount Sinai Medical Center, New York, NY, Dr. James F. Holland
1983-1985 Clinical Residency, Internal Medicine, Jewish General Hospital/McGill University, Montreal, Canada, Dr. Harold Frank
1982-1983 Clinical Internship, Internal Medicine, Jewish General Hospital/McGill University, Montreal, Canada, Dr. Harold Frank

Board Certifications

2008 American Board of Internal Medicine- Hospice and Palliative Medicine
2004 American Board of Hospice & Palliative Medicine
1987 American Board of Internal Medicine-Medical Oncology
1985 American Board of Internal Medicine

Experience/Service

Other Appointments/Responsibilities

Member, Systems Policy & Practice: Clinical Survivorship Care Workgroup,a collaboration between the American Cancer Society (ACS) and the George Washington University Cancer Institute (GWCI), Atlanta, GA, 2011
Member, National Institute of Health National Cancer Institute Physicians Data Query (PDQ) Supportive and Palliative Care Advisory Board, Washington, DC, 2009-present

Institutional Committee Activities

Member, Advance Care Planning Quality Improvement Work Group, 4/2011-present
Chair, Advance Care Planning Pilot Planning Work Group, 4/2011-present

Honors and Awards

2011 Nominated, Texas Business Women Award, The University of Texas MD Anderson Cancer Center Institutional Awards Committee (Dr. Eduardo Bruera)
2010 Fellow, American Academy of Hospice and Palliative Medicine
2010 Nominated, The Hastings Center Cunniff-Dixon Physicians Awards in recognition of clinical contributions and commitment to the cause of end-of-life medical care. Cunniff-Dixon Foundation 2010 (The University of Texas M. D. Anderson Cancer Center Institutional Awards Committee)
2009 Nominated,The Hastings Center Cunniff-Dixon Physicians Awards in recognition of clinical contributions and commitment to the cause of end-of-life medical care (by Colleen Gallegher, PhD, Executive Director Clinical Ethics), Cunniff-Dixon Foundation
1992 Fellow, American College of Physicians

Professional Memberships

American Academy of Hospice and Palliative Medicine
Member, Scientific Sub-Committee, 6/2012-present
American Academy of Hospice and Palliative Medicine
Member, Research Committee, 6/2012-1/2014
American Academy of Hospice and Palliative Medicine
Ad-hoc Member, Publications Committee, 2012-present
American Academy of Hospice and Palliative Medicine
Member, Membership and Communities Strategic Coordinating Committee, 8/2010-2012
American Pain Society
Member, 1988-present
American Society of Clinical Oncology
Member, 1989-present
Multinational Association of Supportive Care in Cancer (MASCC)
Member, 1999-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Kim SH, Hui D, Kilgore KL, Nguyen LMT, Hall S, Fajardo J, Cox-Miller T, Rhondali W, Kang JH, Palla SL, Del Fabbro E, Zhukovsky DS, Reddy SK, Elsayem AF, Dalal S, Walker P, Dev R, Yennurajalingam S, Reddy A, Bruera E. The Accuracy of Probabilistic versus Temporal Clinician’s Prediction of Survival for Patients with Advanced Cancer: A Preliminary Report. The Oncologist, 10/2011. e-Pub 10/2011.
2. Hui D, Kilgore KL, Nguyen LMT, Hall S, Fajardo J, Cox-Miller T, Urbauer D, Fellman B, Rhondali W, Kang JH, Kim H, Del Fabbro E, Zhukovsky DS, Reddy SK, Elsayem AF, Dalal S, Walker P, Dev R, Yennurajalingam S, Bruera E. Predictors of In-hospital Mortality in Advanced Cancer Patients Admitted to an Acute Palliative Care Unit (APCU): A prospective study. 2011 Multinational Association of Supportive Care in Cancer, 2011.
3. Fainsinger RL, Nekolaichuk C, Lawlor P, Hagen N, Bercovitch M, Fisch M, Galloway L, Kaye G, Landman W, Spruyt O, Zhukovsky D, Bruera E, Hanson J. An International Multicentre Validation Study of a Pain Classification System for Cancer Patients. Eur J Cancer 46(16):2896-904., 11/2010. PMID: 20483589.
4. Parsons HA, de la Cruz MJ, Zhukovsky DS, Hui D, Delgado-Guay MO, Akitoye AE, El Osta B, Palmer L, Palla SL, Bruera E. Characteristics of patients who refuse do-not-resuscitate orders upon admission to an acute palliative care unit in a comprehensive cancer center. Cancer 116(12):3061-70, 6/2010. PMID: 20564412.
5. Hui D, Elsayem A, De la Cruz M, Berger A, Zhukovsky DS, Palla S, Evans A, Fadul N, Palmer JL, Bruera E. Availability and integration of palliative care at United States cancer centers. JAMA 17(303;11):1054-61, 3/2010. PMID: 20233823.
6. Lowy J, Lebovits A, Zhukovsky DS. Defending patient autonomy: the case of the challenging spouse. J Pain Palliat Care Pharmacotherapy 23(4):368-70, 11/2009.
7. Fine P, Portenoy R, Chou R, Cruciani R, Gordon D, Inturrisi C, Jackson K, Moskowitz M, Pasternak G, Raja S, Webster L, Zhukovsky DS. Establishing "best practices" for opioid rotation: conclusions of an expert panel. J Pain Symptom Manage 38(3):418-25, 9/2009. PMID: 19735902.
8. Zhukovsky DS, Herzog C, Kaur G, Palmer JL, Bruera E. The impact of palliative care consultation of symptom assessment, communication needs pediatric cancer patients. J Pal Med 12(4):343-9, 4/2009. PMID: 19327071.
9. Sanft T, Hauser J, Rosielle D, Weissman D, Elsayem A, Zhukovsky DS, Coyle N. Physical pain and emotional suffering: the case for palliative sedation. Journal of Pain 10(3):238-242, 3/2009. PMID: 1910121.
10. Zhukovsky DS, Hwang JP, Palmer JL, Willey J, Flamm AL, Smith ML. Wide variation in content of inpatient Do-Not-Resuscitate order forms used at National Cancer Institute-designated cancer centers in the United States. Supp Care Cancer 17(2):109-115, 2/2009. PMID: 18682989.
11. Slatkin N, Thomas J, Lipman A, Wilson G, Boatwright M, Wellman C, Zhukovsky DS, Stephenson R, Portenoy R, Stambler N, Israel R,. Methylnaltrexone for the relief of opioid-induced constipation in advanced illness. J Support Oncol 7(1):39, 1/2009. PMID: 19278178.
12. Dalal S, Zhukovsky DS. Pathophysiology and management of fever. J Support Oncol 4:(1): 9-16, 2006. PMID: 16444847.
13. Dalal S, Zhukovsky DS. Pathophysiology and management of hot flashes. J Support Oncol 4:315-20, 325, 2006. PMID: 16892692.
14. Walsh D, Zhukovsky DS. Communication in palliative medicine: a pilot study of a problem list to capture complex medical information. Am J Hosp Palliat Care 21:365-71, 2004. PMID: 15510574.
15. Elsayem A, Swint K, Fisch MJ, Palmer JL, Reddy S, Walker P, Zhukovsky D, Knight P, Bruera E. Palliative care inpatient service in a comprehensive cancer center: clinical and financial outcomes. J Clin Oncol 22:2008-14, 2004. PMID: 15143094.
16. Gutgsell T, Walsh D, Zhukovsky DS, Gonzales F, Lagman R. A prospective study of the pathophysiology and clinical characteristics of pain in a palliative medicine population. Am J Hosp Palliat Care 20:140-8, 2003. PMID: 12693647.
17. Potluri V, Zhukovsky DS. Recent advances in malignant bowel obstruction: an interface of old and new. Curr Pain Headache Rep 7:270-8, 2003. PMID: 12828876.
18. Zhukovsky DS. Fever and sweats in the patient with advanced cancer. Hematol Oncol Clin North Am 16(3):579-88, 6/2002. PMID: 12170569.
19. Dubois MY, Cahana A, Portenoy RK, Zhukovsky DS. Is optimal pain relief at the end of life real relief? Pain Med 3:289-91, 2002. PMID: 15099264.
20. Zhukovsky DS. A model of palliative care: the palliative medicine program of the Cleveland Clinic Foundation. A World Health Organization Demonstrations Project. Support Care Cancer 8:268-77, 2000. PMID: 10923766.
21. Stagno SJ, Zhukovsky DS, Walsh D. Bioethics: communication and decision-making in advanced disease. Semin Oncol 27:94-100, 2000. PMID: 10697026.
22. Zhukovsky DS, Abdullah O, Richardson M, Walsh D. Clinical evaluation in advanced cancer. Semin Oncol 27:14-23, 2000. PMID: 10697018.
23. Nelson KA, Walsh D, Abdullah O, McDonnell F, Homsi J, Komurcu S, LeGrand SB, Zhukovsky DS. Common complications of advanced cancer. Semin Oncol 27:34-44, 2000. PMID: 10697020.
24. LeGrand SB, Walsh D, Nelson K, Zhukovsky DS. Development of a clinical fellowship program in palliative medicine. J Pain Symptom Manage 20:345-52, 2000. PMID: 11068156.
25. Nelson KA, Walsh D, Behrens C, Zhukovsky DS, Lipnickey V, Brady D. The dying cancer patient. Semin Oncol 27:84-9, 2000. PMID: 10697024.
26. Zhukovsky DS, Walsh D, Donna M. The relative potency between high dose oral oxycodone and intravenous morphine: a case illustration. J Pain Symptom Manage 18:53-5, 1999. PMID: 10439573.
27. Kaplan R, Parris WC, Citron ML, Zhukovsky D, Reder RF, Buckley BJ, Kaiko RF. Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain. J Clin Oncol 16:3230-7, 1998. PMID: 9779696.
28. Zhukovsky DS, Gorowski E, Hausdorff J, Napolitano B, Lesser M. Unmet analgesic needs in cancer patients. J Pain Symptom Manage 10:113-9, 1995. PMID: 7537317.
29. Sciortino AD, Carlton DC, Axelrod A, Eng M, Zhukovsky DS, Vinciguerra V. The efficacy of administering blood transfusions at home to terminally ill cancer patients: evaluation of symptom control and quality of life issues. J Palliat Care 9:14-7, 1993. PMID: 8271100.
30. Ayukawa HM, Saltzburg D, Mukherjee BB. In vivo induction of endogenous retroviruses in Balb/c mouse hepatocytes by successive treatments with carbon tetrachloride and bromodeoxyuridine. Int J Cancer 24:498-503, 1979. PMID: 93580.
31. Zhukovsky DS, Cohen M, Rozmus C, Robert R, Bruera E, Wells R, Allo J. The Symptom Experience of English and Spanish-speaking Children with Advanced Cancer: Child and Family Caregiver Perspective. Journal of Pain and Symptom Management. Submitted.

Invited Articles

1. Lebovits A, Zhukovsky DS. Whose pain is it anyway? Journal of Cancer Pain and Symptom Palliation 1(3):31-2, 2006.
2. Zhukovsky DS, Lebovitz A, Gershon K, Halpern J, Passik S. von Gunten C. Ethics and cancer pain: Why? Journal of Cancer Pain and Symptom Palliation 1(1):99-100, 2005.
3. Zhukovsky DS, Lebovits A, Fine P, Taylor MC, Paice J. Severe cancer pain: testing the limits of maleficence? Journal of Cancer Pain and Symptom Palliation 1(2):47-50, 2005.
4. Zhukovsky DS. An Insightful Look Into the Lives of Cancer Patients and their Families: a review of the human side of cancer by Holland JC and Lewis S. Journal Pain and Symptom Management 23:79-80, 2002.
5. Elsayem A, Zhukovsky DS. Evaluation and management of delirium in the cancer patient. Primary Care and Cancer 21:31-36, 2001.
6. Zhukovsky DS. Palliative medicine: problem areas in pain and symptom management . Progress in Palliative Care 3:116, 1995.
7. Zhukovsky DS. Diagnosis, evaluation and management of cancer pain. Hosp Phys 28:13-22, 1992.

Editorials

1. Zhukovsky DS. Palliative Care: A Call for Assessment. Primary Care and Cancer 21:11-12, 2001.
2. Zhukovsky DS. Decompressive Surgery plus Radiotherapy Alone for Cord Compression (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC FACS Issue 4), 2005.
3. Lebovits A Zhukovsky DS. Ethics and Cancer Pain-Why? Journal of Cancer Pain and Symptom Palliation 1:99-101, 2005.
4. Zhukovsky DS. End-of-Life care in pediatric cancer patients: three studies. (PC FACS). Journal of Palliative Medicine 9(4)(PC-FACS Issue 7):1013-5, 2006.
5. Zhukovsky DS. Symptom Control with Erlotinib (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 17), 2006.
6. Zhukovsky DS. Pediatric Palliative Care Outreach (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine, 2007.
7. Zhukovsky DS. Resolution of Parental Grief (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 26), 2007.
8. Zhukovsky DS. Advance Care Planning in Stem-Cell Transplant Patients (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care, (American Academy of Hospice and Palliative Medicine)(PC-FACS Issue 33), 2008.
9. Zhukovsky DS. Exercise for the Management of Cancer-Related Fatigue in Adults (Commentary). PC-FACS (Fast Article Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 46), 2008.
10. Zhukovsky DS. Hope and Prognostic Disclosure (Commentary). PC-FACS (Fast Article Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 36), 2008.
11. Zhukovsky DS. Parental Goals of Care at the End of Life (Commentary). PC-FACS (Fast Article Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 39), 2008.
12. Zhukovsky DS. Positron Emission Tomography and Improved Survival in Patients with Lung Cancer (Commentary). PC-FACS (Fast Article Critical Summaries for Clinicians in Palliative Care), American Academy of Hospice and Palliative Medicine(PC-FACS Issue 53), 2008.
13. Zhukovsky DS. Physician Orders for Life-Sustaining Care: Do All Hospice Patients Want the Same Level of Care (Commentary). PC-FACS (Fast Article Summaries for Clinicians in Palliative Care) American Academy of Hospice and Palliative Medicine(PC-FACS Issue 61), 2009.
Other Articles
1. Zhukovsky DS. End of Life Care: Symptom Management. Highlights in Pain Management: Excerpts from the Meet the Professor Roundtable. CEMedicus, 2005. e-Pub 2005.
2. Zhukovsky DS. Palliative Care SIG Visits Canuck Place. American Pain Society E-News, 2004.
3. Glajchen, M, Zhukovsky DS. Palliative Care Special Interest Group: Six Years Later. American Pain Society Bulletin, 2004.
4. Zhukovsky, DS, Paice J. A Focus on the APS Palliative Care Special Interest Group. American Pain Society Bulletin 13(3):13, 2003.
5. Zhukovsky, DS, Wiffen PJ, Lipman AG. Palliative care initiatives in the decade of pain management and research. American Pain Society Bulletin 13(3):6-7, 2003.
6. Zhukovsky, DS, Glajchen M. Palliative care-does the APS membership need it? . American Pain Society Bulletin 11(6):5,17, 2001.

Book Chapters

1. Robert R, Zhukovsky DS. Pediatric Palliative Care. In: Oxford American Handbook of Hospice and Palliative Medicine. Ed(s) Edited by Eduardo Bruera and Sriram Yennurajalingam. Oxford University Press: New York, 2011. ISBN: 13: 9780195380156.
2. Zhukovsky DS, Bruera E. A transcultural perspective of advanced directives in palliative care. In: Palliative Medicine. Chapter 109. Edward Arnold (Publishers) Ltd. London, 1035-43, 2006.
3. Dalal S, Zhukovsky DS, Bruera E. Fever, sweats, and hot flashes. In: Palliative Medicine. Chapter 77. Edward Arnold (Publishers) Ltd. London, 736-49, 2006.
4. Yennurajalingam S, Zhukovsky DS. Pain and Symptom Management in Advanced Coloretal Cancer. In: Colorectal Cancer in Elderly Patient: Assessment and Treatment. Ed(s) Litchman SM. CMP Healthcare Media: Manhasset, NY, 89-105, 2005.
5. Madden, RM, Koontz-Webb SE, Zhukovsky DS, Mullen CA. Supportive Care: Symptom Control. In: Pediatric Oncology. Chapter 16. Ed(s) Chan KW, Raney RB Jr. Springer Science and Business Media, Inc: New York, NY, 218-243, 2005.
6. Zhukovsky DS. Palliation of fever and sweats: the heat is on. In: The Cambridge Handbook of Advanced Cancer Care. Ed(s) Bruera E, Fisch MF. Cambridge University Press: New York, NY, 408-15, 2003.
7. Zhukovsky DS. In: Fever and sweats in the patient with advanced cancer. Ed(s) Walker P, Bruera E. Hematology/ Oncology Clinics of North America: Philadelphia, 579-588, 2002.
8. Zhukovsky DS. Palliation in patients with renal cell carcinoma: the interface with antineoplastic therapy. In: Immunology and Clinical Management. Renal Cell Carcinoma: Molecular Biology. Humana Press, 2000.
9. Zhukovsky DS. Assessment of the patient with cancer pain. In: Management of Cancer-Related Pain. Ed(s) Arbit E. Futura Publishing Co: Mount Kisco, NY, 55-61, 1993.
10. Saltzburg D, Foley KM. Management of pain in pancreatic cancer. In: Surg Clin North Am. 69, 629-49, 1989. ISBN: 2658165.

Letters to the Editor

1. Dalal S, Zhukovsky DS. Pathophysiology and management of fever. Journal of Supportive Oncology 4(6):265-6, 2006.

Manuals, Teaching Aids, Other Teaching Publications

1. Zhukovsky DS. Ascites, 1st. Ed(s) Ewert-Flannagan P, Bruera E. (eds.) M.D. Anderson's Guide to Palliative Care for Nurses,: Houston, TX, 62-64, 2006.
2. Zhukovsky DS. Dyspnea, 1st. Ed(s) Ewert-Flannagan P, Bruera E. (eds.) M. D. Anderson's Guide to Palliative Care for Nurses,: Houston, TX, 55-59, 2006.
3. Zhukovsky DS. Pruritus, 1st. Ed(s) Ewert-Flannagan P, Bruera E. (eds.) M. D. Anderson's Guide to Palliative Care for Nurses,: Houston, TX, 64-65, 2006.
4. Zhukovsky DS. Palliative Care in Pediatrics, The MD Anderson Supportive and Palliative Care Handbook. Chapter 16, 3rd. Ed(s) Elsayem A, Bruera E. The University of Texas Health Science Center at Houston: Houston, TX, 2008.
5. Zhukovsky DS. Palliative Care in Pediatrics, The MD Anderson Supportive and Palliative Care Handbook. Chapter 16, 4th. Ed(s) Elsayem E, Bruera E. The University of Texas Health Sciences Center: Houston, 2011.

Grant & Contract Support

Title: Open-Labeled Extension Study to Assess the Safety of a Fixed Dose of Subcutaneous Methylnaltrexone in Subjects with Advanced Illness and Opioid-Induced Constipation
Funding Source: Wyeth Pharmaceuticals
Role: Principal Investigator
Duration: 1/26/2009 - 5/27/2011
 
Title: Symptom Profiles in English and Spanish Speaking Children with Cancer
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator-MDACC
Duration: 8/31/2008 - 8/31/2011
 
Title: A Randomized, Double-Blind, Placebo-Controlled Study of a Fixed Dose of Subcutaneous Methylnaltrexone in Adults with Advanced Illness and Opioid-Induced Constipation: Efficacy, Safety, and Additional Health Outcomes
Funding Source: Wyeth Pharmaceuticals
Role: Principal Investigator
Duration: 4/23/2008 - 5/27/2011

Last updated: 7/22/2014