Dragan Mirkovic, Ph.D.
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
1993 | State University of New York at Stony Brook, Stony Brook, NY, USA, PHD, Applied Mathematics |
1990 | University of Zagreb, Zagreb, HRV, MS, Nuclear Engineering |
1983 | University of Zagreb, Zagreb, HRV, BS, Nuclear Engineering |
Experience & Service
Academic Appointments
Associate Member, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2006 - Present
Assistant Professor, Department of Dept. of Computer Science, University of Houston, Houston, TX, 2003 - 2005
Research Faculty, Department of Dept. of Computer Science, University of Houston, Houston, TX, 1998 - 2003
Assistant Professor, Department of Mathematics, Iowa State University, Ames, IA, 1994 - 1999
Postdoctoral Research Associate, Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, NY, 1993 - 1994
Research/Teaching Assistant, Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, NY, 1990 - 1993
Visiting Scientist, Department of Nuclear Energy, Brookhaven National Laboratory, Upton, NY, 1989 - 1990
Research Associate, Department of Nuclear Energy, University of Zagreb, Zagreb, 1984 - 1990
Honors & Awards
1990 | Research Fellowship (Selective), State University of New York Stony Brook |
1989 | IAEA Fellowship, Brookhaven National Laboratory |
Selected Publications
Peer-Reviewed Articles
- Peeler CR, Mirkovic D, Titt U, Blanchard P, Gunther JR, Mahajan A, Mohan R, Grosshans DR. Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma. Radiother Oncol 121(3):395-401, 2016. e-Pub 2016. PMID: 27863964.
- Blanchard P, Wong AJ, Gunn GB, Garden AS, Mohamed AS, Rosenthal DI, Morrison WH, Skinner HD, Phan J, Beadle BM, Crutison J, Amin M, Mirkovic D, Zhang X, Zhu XR, Mohan R, Fuller CD, Frank SJ. Toward a Model-Based Strategy for Patient Selection for Proton Therapy-External Validation of Normal Tissue Complication Probability Models on a Head and Neck Proton Cohort. Int J Radiat Oncol Biol Phys 96(2S):S223, 2016. PMID: 27675837.
- Huang JY, Followill DS, Howell RM, Liu X, Mirkovic D, Stingo FC, Kry SF. Approaches to reducing photon dose calculation errors near metal implants. Med Phys 43(9):5117, 2016. PMID: 27587042.
- Yepes PP, Eley JG, Liu A, Mirkovic D, Randeniya S, Titt U, Mohan R. Validation of a track repeating algorithm for intensity modulated proton therapy: clinical cases study. Phys Med Biol 61(7):2633-2645, 2016. e-Pub 2016. PMID: 26961764.
- Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761-776, 2016. PMID: 26843239.
- Titt U, Sell M, Unkelbach J, Bangert M, Mirkovic D, Oelfke U, Mohan R. Degradation of proton depth dose distributions attributable to microstructures in lung-equivalent material. Med Phys 42(11):6425-6432, 2015. PMID: 26520732.
- Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 42(11):6234-6247, 2015. PMID: 26520716.
- Rechner LA, Eley JG, Howell RM, Zhang R, Mirkovic D, Newhauser WD. Risk-optimized proton therapy to minimize radiogenic second cancers. Phys Med Biol 60(10):3999-4013, 2015. e-Pub 2015. PMID: 25919133.
- Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015. PMID: 25984967.
- Zhang R, Mirkovic D, Newhauser WD. Visualization of risk of radiogenic second cancer in the organs and tissues of the human body. Radiat Oncol 10(1):107, 2015. e-Pub 2015. PMID: 25927490.
- Huang JY, Kerns JR, Nute JL, Liu X, Balter PA, Stingo FC, Followill DS, Mirkovic D, Howell RM, Kry SF. An evaluation of three commercially available metal artifact reduction methods for CT imaging. Phys Med Biol 60(3):1047-1067, 2015. e-Pub 2015. PMID: 25585685.
- Shao Y, Sun X, Lou K, Zhu XR, Mirkovic D, Poenisch F, Grosshans D. In-beam PET imaging for on-line adaptive proton therapy: An initial phantom study. Phys Med Biol 59(13):3373-88, 2014. e-Pub 2014. PMID: 24874943.
- Huang JY, Eklund D, Childress NL, Howell RM, Mirkovic D, Followill DS, Kry SF. Investigation of various energy deposition kernel refinements for the convolution superposition method. Med Phys 40(12):121721, 2013. PMID: 24320507.
- Perles LA, Mirkovic D, Anand A, Titt U, Mohan R. LET dependence of the response of EBT2 films in proton dosimetry modeled as a bimolecular chemical reaction. Phys Med Biol 58(23):8477-91, 2013. e-Pub 2013. PMID: 24240474.
- Newhauser WD, Rechner L, Mirkovic D, Yepes P, Koch NC, Titt U, Fontenot JD, Zhang R. Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams. Radiat Meas 58:37-44, 2013. PMID: 25147474.
- Zhang R, Fontenot JD, Mirkovic D, Hendricks JS, Newhauser WD. ADVANTAGES OF MCNPX-BASED LATTICE TALLY OVER MESH TALLY IN HIGH-SPEED MONTE CARLO DOSE RECONSTRUCTION FOR PROTON RADIOTHERAPY. Nucl Technol 183(1):101-106, 2013. PMID: 25435594.
- Robertson D, Mirkovic D, Sahoo N, Beddar S. Quenching correction for volumetric scintillation dosimetry of proton beams. Phys Med Biol 58(2):261-273, 2013. e-Pub 2012. PMID: 23257200.
- Wang LL, Perles LA, Archambault L, Sahoo N, Mirkovic D, Beddar S. Determination of the quenching correction factors for plastic scintillation detectors in therapeutic high-energy proton beams. Phys Med Biol 57(23):7767-81, 2012. e-Pub 2012. PMID: 23128412.
- Perles LA, Mirkovic D, Sawakuchi GO, Titt U. Monte Carlo investigation of rebinning material density distributions of lung parenchyma phantoms in proton therapy. Nuclear Technology 175(1):22-26, 2011.
- Yepes PP, Brannan T, Huang J, Mirkovic D, Newhauser WD, Taddei PJ, Titt U. Application of a Fast Proton Dose Calculation Algorithm to a Thorax Geometry. Radiat Meas 45(10):1367-1368, 2010. PMID: 21544230.
- Taddei PJ, Mahajan A, Mirkovic D, Zhang R, Giebeler A, Kornguth D, Harvey M, Woo S, Newhauser WD. Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation. Physics in Medicine and Biology 55(23):7067-7080, 2010. e-Pub 2010. PMID: 21076189.
- Yepes PP, Mirkovic D, Taddei PJ. A GPU implementation of a track-repeating algorithm for proton radiotherapy dose calculations. Physics in Medicine and Biology 55(23):7107-7120, 2010. e-Pub 2010. PMID: 21076192.
- Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency. Physics in Medicine and Biology 55(23):7097-7106, 2010. e-Pub 2010. PMID: 21076194.
- Taddei PJ, Howell RM, Krishnan S, Scarboro SB, Mirkovic D, Newhauser WD. Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma. Physics in Medicine and Biology 55(23):7055-7065, 2010. e-Pub 2010. PMID: 21076199.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Med Phys 37(9):4960-70, 2010. PMID: 20964215.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Medical Physics 37(9):4960-4970, 2010. PMID: 20964215.
- Sawakuchi GO, Titt U, Mirkovic D, Ciangaru G, Zhu XR, Sahoo N, Gillin MT, Mohan R. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams. Physics in Medicine and Biology 55(3):711-721, 2010. e-Pub 2010. PMID: 20071752.
- Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser WD. Reducing Stray Radiation Dose for a Pediatric Patient Receiving Proton Craniospinal Irradiation. Nuclear Technology 168(1):108-112, 2009. PMID: 20865143.
- Fontenot JD, Taddei P, Zheng Y, Mirkovic D, Newhauser WD. Ambient Dose Equivalent Versus Effective Dose for Quantifying Stray Radiation Exposures to a Patient Receiving Proton Therapy for Prostate Cancer. Nucl Technol 168(1):173-177, 2009. PMID: 20844596.
- Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Kornguth D, Mohan R, Newhauser WD. Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams. Phys Med Biol 54(8):2259-2275, 2009. e-Pub 2009. PMID: 19305045.
- Newhauser WD, Fontenot JD, Mahajan A, Kornguth D, Stovall M, Zheng Y, Taddei PJ, Mirkovic D, Mohan R, Cox JD, Woo S. The risk of developing a second cancer after receiving craniospinal proton irradiation. Physics in Medicine and Biology 54(8):2277-2291, 2009. e-Pub 2009. PMID: 19305036.
- Taddei PJ, Krishnan S, Mirkovic D, Yepes P, Newhauser WD. Effective Dose from Stray Radiation for a Patient Receiving Proton Therapy for Liver Cancer. AIP Conf Proc 1099:445-449, 2009. PMID: 20865142.
- Newhauser WD, Fontenot JD, Taddei PJ, Mirkovic D, Giebeler A, Zhang R, Mahajan A, Kornguth D, Stovall M, Yepes P, Woo S, Mohan R. Contemporary Proton Therapy Systems Adequately Protect Patients from Exposure to Stray Radiation. AIP Conf Proc 1099(1):450-455, 2009. PMID: 20844607.
- Ezhil M, Vedam S, Balter P, Choi B, Mirkovic D, Starkschall G, Chang JY. Determination of patient-specific internal gross tumor volumes for lung cancer using four-dimensional computed tomography. Radiation Oncology 4:4, 2009. e-Pub 2009. PMID: 19173738.
- Sawakuchi GO, Titt U, Mirkovic D, Mohan R. Density heterogeneities and the influence of multiple Coulomb and nuclear scatterings on the Bragg peak distal edge of proton therapy beams. Physics in Medicine and Biology 53(17):4605-4619, 2008. e-Pub 2008. PMID: 18678928.
- Newhauser WD, Giebeler A, Langen KM, Mirkovic D, Mohan R. Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants?. Physics in Medicine and Biology 53(9):2327-2344, 2008. e-Pub 2008. PMID: 18421122.
- Taddei PJ, Fontenot JD, Zheng Y, Mirkovic D, Lee AK, Titt U, Newhauser WD. Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer. Physics in Medicine and Biology 53(8):2131-2147, 2008. e-Pub 2008. PMID: 18369278.
- Yang XF, Zhang S, bMirkovic D, Zhang QE, Wang H. Different Processing Sites in the Generation of Tumor Antigen Epitopes and Viral Epitopes Suggest New Direction for Anti-Tumor Immunotherapy. Faseb Journal 22, 2008.
- Fontenot J, Taddei P, Zheng Y, Mirkovic D, Jordan T, Newhauser W. Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer. Physics in Medicine and Biology 53(6):1677-1688, 2008. e-Pub 2008. PMID: 18367796.
- Zheng Y, Fontenot J, Taddei P, Mirkovic D, Newhauser W. Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unit. Physics in Medicine and Biology 53(1):187-201, 2008. e-Pub 2007. PMID: 18182696.
- Kurzak J, Mirkovic D, Pettitt BM, Johnsson SL. Automatic Generation of FFT for Translations of Multipole Expansions in Spherical Harmonics. International Journal of High Performance Computing Applications 22(2):219-230, 2008. PMID: 19763233.
- Canic S, Tambaca J, Mikelic A, Hartley CJ, Mirkovic D, Chavez J, Rosenstrauch D. Blood flow through axially symmetric sections of compliant vessels: new effective closed models. Conf Proc IEEE Eng Med Biol Soc 5:3696-3699, 2007. PMID: 17271096.
- Yang XF, Mirkovic D, Zhang S, Zhang QE, Yan Y, Xiong Z, Yang F, Chen IH, Li L, Wang H. Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. International Journal Immunopathology Pharmacology 19/4:853-70, 2006. PMID: 17166407.
- Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang X. An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene 24:4778-4788, 2005. PMID: 15870695.
- Canic S, Ravi-Chandar K, Krajcer Z, Mirkovic D, Lapin S. Mathematical Model analysis of Wallstent and Aneurx: dynamic responses of bare-metal endoprosthesis compared with those of stent-graft. Tex Heart Inst J 32/4(4):502-6, 2005. PMID: 16429893.
- Mirkovic D, Johnson SL. Automatic performance tuning for fast fourier transforms. International Journal of High Performance Computing Applications 18/1:47-64, 2004.
- Mirkovic D, Johnson SL. CODELAB: A developers' tool for efficient code generation and optimization. Lecture Notes in Computer Science 2657/4:729-738, 2003.
- Canic S, Mirkovic D. A hyperbolic system of conservation laws arising in modeling endovascular treatment of abdominal aortic aneurysm. Hyperbolic Problems: Theory, numerics, applications 141:227-236, 2001.
- Mirkovic D, Johnsson SL. Automatic Performance Tuning in UHFFT Library. Lecture Notes in Computer Science 2073/1:71-80, 2001.
- Canic S, Mirkovic D. Numericdal study of riemann problems for the two-dimensional unsteady transonic small disturbance equation. SIAM Journal on Applied Mathematics 58:1365-1393, 1998.
- Mirkovic D, Diamond DJ, Hsu CJ, Fitzpatrick R. The potential for catastrophic fuel damage during beyond-design-basis over pressurization accidents in a boiling water reactor. Nuclear Technology 93:158-165, 1991.
- Mirkovic D, Diamond DJ. Effect of flusing of boron during a boiling water reactor anticipated transsient without scram. Nuclear Technology 95:162-174, 1991.
- Diamond DJ, Hsu C-J, Fitzpatrick, R, Mirkovic D. Reactivity accidents with the potential for catastrophic fuel damage. Nuclear Safety 31:311-317, 1990.
- Mirkovic D, Diamond DJ. Boron Flusing during BWR ATWS. Trans of American Nuclear Society 61:222-223, 1990.
Editorials
- Rumbaut RE, Mirkovic D. Magnetic therapy for edema in inflammation: a physiological assessment. Am J Physiol Heart Circ Physiol 294(1):19-20, 2008. PMID: 18032520.
Abstracts
- Mirkovic D, Titt U, Yepes P and Mohan R. Effects of Motion and Variable RBE in a Lung Patient Treated with Passively Scattered Protons, AAPM 2016 Washington, DC. Medical Physics 43(6):3336, 2016. PMID: 28047696.
- Titt U, Mirkovic D, Yepes P, Liu A, Peeler C, Randenyia S and Mohan R. 4D and 5D Proton Dose Evaluation with Monte Carlo, AAPM 2016 Washington, DC. Medical Physics 43(6):3489-3490, 2016. PMID: 28046764.
- Kim D, Titt U and Mirkovic D. Uptake Dose Response in Lung Correlates Linearly with Proton Therapy Dose, AAPM 2016 Washington, DC. Medical Physics 43(6):3491-3492, 2016. PMID: 28048762.
- Yepes P, Titt U, Mirkovic D, Liu A, Frank S and Mohan R. Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?, AAPM 2016 Washington, DC. Medical Physics 43(6):3496, 2016. PMID: 28048730.
- Peeler C, Mirkovic D, Titt U, Grosshans D and Mohan R. Voxel-Level Analysis of Adverse Treatment Response in Pediatric Patients Treated for Ependymoma with Passive Scattering Proton Therapy, AAPM 2016 Washington, DC. Medical Physics 43(6):3828-3829, 2016. PMID: 28048899.
- Guan F, Bronk L, Kerr M, Wang X, Li Y, Peeler C, Sahoo N, Patel D, Mirkovic D, Titt U, Grosshans D and Mohan R. Investigation of LET Spectral Dependence of the Biological Effects of Therapeutic Protons, AAPM 2016 Washington, DC. Medical Physics 43(6):3843, 2016. PMID: 28047702.
- Patel D, Bronk L, Guan F, Peeler C, Mirkovic D, Grosshans D, Jakel O, Abdollahi A, Titt U and Mohan R. Experimental Investigation of RBE for Lung Cancer Cell Lines as a Function of Dose and LET in Proton, Helium and Carbon Beams, AAPM 2016 Washington, DC. Medical Physics 43(6):3843-3844, 2016. PMID: 28047053.
- Kerr M, Bronk L, Guan F, Patel D, Li Y, Wang X, Sahoo N, Peeler C, Titt U, Mirkovic D, Grosshans D and Mohan R. Spatial Mapping of Scanned Proton Biologic Effect Using the High-Throughput Technique, Continued, AAPM 2016 Washington, DC. Medical Physics 43(6):3888, 2016. PMID: 28046268.
- Huang J, Followill D, Howell R, Liu X, Mirkovic D, Stingo F, Kry S. Dosimetric Impact of Implementing Metal Artifact Reduction Methods and Metal Energy Deposition Kernels for Photon Dose Calculations, AAPM 2015 Anaheim, California. Medical Physics 42(6):3409, 2015. PMID: 26127995.
- Taleei R, Peeler C, Guan F, Patel D, Titt U, Mirkovic D, Grosshans D, Mohan R. Modeling Biological Response to Proton Irradiation and Evaluating Its Potential Clinical Consequences, AAPM 2015 Anaheim, California. Medical Physics 42(6):3461, 2015. PMID: 26128210.
- Mirkovic D, Peeler C, Grosshans D, Titt U, Taleei R, Mohan R. Modeling Relative Biological Effectiveness of Protons for Radiation Induced Brain Necrosis, AAPM 2015 Anaheim, California. Medical Physics 42(6):3461, 2015. PMID: 26128212.
- Yepes P, Mirkovic D, Mohan R. Track Repeating Algorithm for Proton Therapy Applied to Intensity Modulated Proton Therapy for Head-And-Neck Patients, AAPM 2015 Anaheim, California. Medical Physics 42:3513, 2015. PMID: 26128429.
- Peeler C, Taleei R, Guan F, Bronk L, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers, AAPM 2015 Anaheim, California. Medical Physics 42(6):3529, 2015. PMID: 26128495.
- Guan F, Bronk L, Kerr M, Titt U, Wang X, Taleei R, Peeler C, Patel D, Mirkovic D, Grosshans D, Mohan R. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis, AAPM 2015 Anaheim, California. Medical Physics 42(6):3616, 2015. PMID: 26128964.
- Guan F, Titt U, Patel D, Bronk L, Taleei R, Peeler C, Mirkovic D, Grosshans D, Jakel O, Mohan R. Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions, AAPM 2015 Anaheim, California. Medical Physics 42(6):3675, 2015. PMID: 26129285.
- Guan F, Bronk L, Kerr M, Titt U, Taleei R, Mirkovic D, Zhu X, Grosshans D, Mohan R. The Effect of Particle Tracking Step Size Limit On Monte Carlo-Computed LET Spectrum of Therapeutic Proton Beams, AAPM 2014 Austin, Texas. Medical Physics 41(6):534, 2014.
- Huang J, Kerns J, Nute J, Liu X, Stingo F, Followill D, Mirkovic D, Howell R, Kry S. Evaluation of Three Commercial Metal Artifact Reduction Methods for CT Simulations in Radiation Therapy Treatment Planning, AAPM 2014 Austin, Texas. Medical Physics 41:498, 2014.
- Mirkovic D, Yepes P, Titt U, Mohan R. Fast Four Dimensional Monte Carlo Dose Computations for Proton Therapy of Lung Cancer, AAPM 2014 Austin, Texas. Medical Physics 41:535, 2014.
- Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions, AAPM 2014 Austin, Texas. Medical Physics 41(6):534, 2014.
- Bronk L, Guan F, Kerr M, Dinh J, Titt U, Mirkovic D, Lin S, Mohan R, Grosshans D. High-Throughput Mapping of Proton Biologic Effect, AAPM 2014 Austin, Texas. Medical Physics 41(6):505, 2014.
- Randeniya S, Mirkovic D, Titt U, Guan F, Mohan R. Importance of Energy Dependent Protons Per MU Calibration Factors in IMPT Dose Calculations Using Monte Carlo Technique, AAPM 2014 Austin, Texas. Medical Physics 41(6), 2014.
- Titt U, Mirkovic D, Liu A, Anand A, Perles L, Ciangaru G, Mohan R. Commissioning of the MC2 Monte Carlo Dose Computation Engine, AAPM 2014 Austin, Texas. Medical Physics 41:362, 2014.
- Peeler C, Taleei R, Guan F, Bronk L, Grosshans D, Mirkovic D, Titt U, Mohan R. Application of the Repair-Misrepair-Fixation RBE Model to Describe the Results of High Resolution Proton Irradiation Cell Survival Experiments, AAPM 2014 Austin, Texas. Medical Physics 41(6):232, 2014.
- Lou K, Mirkovic D, Sun X, Zhu X, Poenisch F, Grosshans D, Clark J and Shao Y. Intra-Fraction Proton Beam-Range Verification with PET Imaging: Feasibility Studies with Monte Carlo Simulations and Statistical Modeling, AAPM 2014 Austin, Texas. Medical Physics 41:174, 2014.
- Titt U, Mirkovic D, Mohan R. Three-Dimensional Energy Fluence Estimates for Future Treatment Planning Systems, AAPM 2013 Indianapolis, Indiana. Medical Physics 40:88, 2013.
- Titt U, Liu A, Mirkovic D. Runtime Optimization for the Automatic Monte Carlo Dose Computation System MC2, AAPM 2013 Indianapolis, Indiana. Medical Physics 40:326, 2013.
- Titt U, Guan F, Mirkovic D, Mohan R. On the Out-Of-Field-Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):328, 2013.
- Perles LA, Titt U, Mirkovic D, Mohan R. Modeling the Cell Inactivation Process for High LET Particles by Using the Law of Mass Action, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):272, 2013.
- Huang J, Eklund D, Childress N, Howell R, Mirkovic D, Kry S. Dosimetric Impact of Implementing Kernel Hardening and Material-Specific Kernels in the Convolution/Superposition Method, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):333, 2013.
- Shao Y, Sun X, Lou K, Zhu X, Mirkovic D, Poenisch F, Grosshans D. In-Beam PET Imaging with Depth-Of-Interaction Measurement for Accurate Proton Beam-Range Verification, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):503, 2013.
- Peeler C, Mirkovic D, Perles L, Titt U, Grosshans D, Mohan R. Comparison of Results for RBE-Weighted Dose From Two RBE Models for Proton Therapy Treatment Plans, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):552, 2013.
- Mirkovic D, Titt U, Peeler C, Perles L, Liao Z, Mohan R. Variable RBE and Incidence of Radiation Pneumonitis in Lung Patients Treated with Proton Therapy, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):455, 2013.
- Guan F, Mohan R, Dinh J, Kerr M, Perles L, Mirkovic D, Titt U, Zhu X, Gillin M, Meyn R, Lin S, Grosshans D. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):552, 2013.
- Taddei PJ, Khater N, Youssef B, Jalbout W, Howell RM, Mahajan A, Zhang R, Mirkovic D, Giebeler A, Geara FB, Newhauser WD. Equivalent Dose in Children Receiving Craniospinal Irradiation with Photons in a Developing Country Or with Protons in a Developed Country, AAPM 2013 Indianapolis, Indiana. Medical Physics 40(6):267, 2013.
- Lou K, Mirkovic D, Sun XS, Zhu XR, Clark J, Shao YP. Monte Carlo Simulation Study of In-beam Intra-treatment PET Imaging for Adaptive Proton Therapy - 2013 60th IEEE Nuclear Science Symposium (NSS) / Medical Imaging Conference (MIC) / 20th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, Seoul, South Korea, 2013.
- Mirkovic D, Peeler C, Grosshans D, Titt U, Mohan R. Is Constant RBE Accurate Enough for Determination of Biological Effects in Proton Therapy?. International Journal of Radiation Oncology Biology Physics 84(3), 2012.
- Perles L, Mirkovic D, Anand A, Titt U, Mohan R. Dose Response of EBT2 Film Modeled as a Bimolecular Reaction, AAPM 2012 Charlotte, North Carolina. Medical Physics 39(6):4009, 2012.
- Sell M, Titt U, Perles L, Mirkovic D, Mohan R, Bangert M, Oelfke U. Evaluation of Analytical Proton Dose Predictions with a Lung-Like Plastic Phantom, AAPM 2012 Charlotte, North Carolina. Medical Physics 39(6):3956, 2012.
- Peeler C, Mirkovic D, Grosshans D, Titt U, Mohan R. Correlating Areas of Radiation Toxicity with Relative Biological Effectiveness-Weighted Dose Distributions in Proton Radiotherapy, AAPM 2012 Charlotte, North Carolina. Medical Physics 39(6):3994, 2012.
- Robertson D, Mirkovic D, Beddar S. A Quenching Correction Method for Volumetric Scintillation Dosimetry of Proton Beams, AAPM 2012 Charlotte, North Carolina. Medical Physics 39:3886, 2012.
- Titt U, Mirkovic D, Perles L, Sell M, Peeler C, Liu A, Mohan R. Monte Carlo Phase Space Production to Model Magnetically Scanned Proton Beams for IMPT, AAPM 2012 Charlotte, North Carolina. Medical Physics 39(6):3814, 2012.
- Titt U, Mirkovic D, Liu A, Mohan R. Automatic Monte Carlo Dose Calculations of Proton Treatment Plans, AAPM 2012 Charlotte, North Carolina. Medical Physics 39(6):3805, 2012.
- Mirkovic D, Titt U, Mohan R. Potential Clinical Impact of Dosimetric Uncertainties in Proton Therapy, AAPM 2012 Charlotte, North Carolina. Medical Physics 39:3816, 2012.
- Mohan R, Mirkovic D, Titt U, Song X, Zhu XR, Gillin MT. Experimental Assessment of the Accuracy of a Semi-Empirical Model and a Monte Carlo System for Proton Dose Calculations for Highly Inhomogeneous Media, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3648, 2011.
- Taddei PJ, Jalbout WT, Geara FB, Mirkovic D, Howell RM, Zhang R, Giebeler A, Mahajan A, Newhauser WD. Comparison of the Risk of Second Malignant Neoplasm in a Developed Country Versus a Developing Country for a 13-Year-Old Girl Receiving Craniospinal Irradiation, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3736, 2011.
- Robertson D, Mirkovic D, Mohan R, Beddar S. Voxelized Quenching Correction for Proton Pencil Beams in a Liquid Scintillator Detector, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3816, 2011.
- Randeniya SD, D Mirkovic D, Kry S, Titt U, Newhauser WD, Howell RM. Patient Specific Out-Of-Field Dose Calculation Tool for 6MV and 18MV: Development and Validation, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3736, 2011.
- Yepes P, Mirkovic D, Keyes R, Panchal P. Online Monte-Carlo-Accurate Real-Time Proton Dose Calculator, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3650, 2011.
- Perles LA, Ibbott G, Blatnica A, Mirkovic D, Titt U, Gillin M, Mohan R. 3D Proton Dose Distributions in An Anthropomorphic Lung Phantom, Comparing Monte Carlo, Film, and TLD Measurements, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3780, 2011.
- Mirkovic D, Titt U, Mohan R. Accuracy of Patient Dose Calculation in Proton Therapy of Lung Cancer: A Comparison of Monte Carlo and Pencil Beam Computations, AAPM 2011 Vancouver, Canada. Medical Physics 38:3642, 2011.
- Titt U, Mirkovic D, Anand A, Perles LA, Sawakuchi GO, Mohan R. On the Dependence of Scanned Proton Beam Dose Output Factors On the Field Size and the Accuracy of the Lateral Dose Profiles, AAPM 2011 Vancouver, Canada. Medical physics 38(6):3382, 2011.
- Faught A, Mirkovic D. Implementation of a One Dimensional Analytical Model for Calculating Three Dimensional Linear Energy Transfer in Proton Radiotherapy, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3659, 2011.
- Wang L, Perles L, Archambault L, Sahoo N, Beddar S, Mirkovic D. Application of a Plastic Scintillation Detector in Measuring Depth-Dose Curves for Passive-Scattering Proton Beams, AAPM 2011 Vancouver, Canada. Medical Physics 38(6):3366, 2011.
- Perles L, Sawakuchi G, Mirkovic D, Mohan R, Titt U. Monte Carlo Investigation and Measurements of Distal Edge Degradation in Lung Phantoms with Therapeutic Proton Beams, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37(6):3145, 2010.
- Randeniya S, Mirkovic D, Kry S, Titt U, Newhauser W, Howell R. Automated Photon Monte Carlo Linear Accelerator Model for Calculating In‐Field and Out‐Of‐Field Dose, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37(6):3281, 2010.
- Rechner L, Mirkovic D, Fontenot J, Newhauser W. Modeling Multiple Coulomb Scattering in Therapeutic Proton Beams: A Comparison of Two Algorithms, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37(6):3282, 2010.
- Bednarz B, Mirkovic D, Titt U, Paganetti H. A Joint Research Investigation Comparing MCNPX and Geant4 Monte Carlo Codes to Reduce the Range Uncertainties in Proton Therapy, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37(6):3286, 2010.
- Titt U, Mirkovic D, Sawakuchi G, Perles L, Newhauser W, Taddei P, Mohan R. Adjustment of Lateral and Longitudinal Size of Scanned Proton‐Beam Spots Using a Pre‐Absorber, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37(6):3353, 2010.
- Mirkovic D, Titt U, Sawakuchi G, Mohan R. Biological Effects of Variable RBE in Different Proton Therapy Delivery Modalities, AAPM 2010 Philadelphia, Pennsylvania. Medical Physics 37:3365, 2010.
- Perles LA, Mirkovic D, Sawakuchi GO, Titt U. 16th Biennial Topical Meeting of the American-Nuclear-Society (ANS) and Radiation Protection and Shielding Division (RPSD) 2010, Las Vegas, Nevada. Nuclear Technology 175(1(S1)), 2010.
- Yepes PP, Brannan T, Huang J, Mirkovic D, Newhauser WD, Taddei PJ, Phillip J, Titt U. Application of a fast proton dose calculation algorithm to a thorax geometry - 11th Neutron and Ion Dosimetry Symposium 2009 Cape Town, South Africa. Radiation Measurements 45(10(S1)):1367-1368, 2009.
- Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser WD. Reducing Stray Radiation Dose for a Pediatric Patient Receiving Proton Craniospinal Irradiation - 11th International Conference on Radiation Shielding / 15th Topical Meeting of the Radiation Protection and Shielding Division 2008 Pine Mount, Georgia. Nuclear Technology 168(1):108-112, 2009.
- Fontenot JD, Taddei P, Zheng YS, Mirkovic D, Newhauser WD. Ambient Dose Equivalent versus Effective Dose for Quantifying Stray Radiation Exposures to a Patient Receiving Proton Therapy for Prostate Cancer - 11th International Conference on Radiation Shielding / 15th Topical Meeting of the Radiation Protection and Shielding Division 2008 PIne Mount, Georgia. Nuclear Technology 168(1):173-177, 2009.
- Harvey MC, Taddei PJ, Mirkovic D, Newhauser WD. Nuclear Model Evaluation of Uncertainties in Therapeutic Absorbed Dose and Secondary Neutron Production in Proton Radiotherapy using MCNPX, AAPM 2009 Anaheim, California. Medical Physics 36(6):2702, 2009.
- Peng Y, Balter P, Mirkovic D, Vedam S. Real-time characterization of respiratory motion regularity during radiation therapy, AAPM 2009 Anaheim, California. Medical Physics 36(6):2503, 2009.
- Yepes P, Randeniya S, Taddei PJ, Mirkovic D and Newhauser WD. Reducing the Simulation Time of a Prostate Cancer Clinical Setup by Two Orders of Magnitude, AAPM 2009 Anaheim, California. Medical Physics 36(6):2622, 2009.
- Taddei PJ, Mirkovic D, Fontenot JD, Zheng Y, Kornguth D, Mohan R, Newhauser WD. Second Cancer Risk from Secondary Neutrons for a Boy who Received Proton Craniospinal Irradiation, AAPM 2009 Anaheim, California. Medical Physics 36(6):2628, 2009.
- Mirkovic D, Titt U, Sawakuchi GO, Zhang X, Li Y, Mohan R. Monte Carlo computation of the effective dose in scanning beam proton therapy, AAPM 2009 Anaheim, California. Medical Physics 36(6):2612, 2009.
- Sawakuchi G, Titt U, Mirkovic D, Zhu X, Sahoo N, Bues M, Ciangaru G, Poenisch F, Suzuki K, Arjomandy B, Gillin M, Mohan R. Validation of An MCNPX Monte Carlo Model of a Discrete-Spot Scanning Beam Nozzle and Evaluation of the Beamlet Lateral Envelope of Low Doses, AAPM 2009 Anaheim, California. Medical Physics 36(6):2782-2783, 2009.
- Sawakuch G, Titt U, Ciangaru G, Mirkovic D, Zhu X, Mohan R. The Causes of the Lateral Envelop of Low Doses in Scanning Proton Beamlets, AAPM 2009 Anaheim, California. Medical Physics 36(6):2620, 2009.
- Taddei PJ, Krishnan S, Mirkovic D, Yepes P, Newhauser WD. Effective Dose from Stray Radiation for a Patient Receiving Proton Therapy for Liver Cancer - 20th International Conference on Application of Accelerators in Research and Industry 2008, Ft. Worth, Texas. Application of Accelerators in Research and Industry 1099:445-449, 2009.
- Newhauser WD, Fontenot JD, Taddei PJ, Mirkovic D, Giebeler A, Zhang R, Mahajan A, Kornguth D, Stovall M, Yepes P, Woo S, Mohan R. Contemporary Proton Therapy Systems Adequately Protect Patients from Exposure to Stray Radiation - 20th International Conference on Application of Accelerators in Research and Industry 2008, Fort Worth, Texas. Application of Accelerators in REsearch and Industry 1099:450-455, 2009.
- Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser WD. Reducing Stray Radiation Dose for a Pediatric Patient Receiving Craniospinal Irradiation with Protons, AAPM 2008 Houston, Texas. Medical Physics 35(6), 2008.
- Mirkovic D, Vedam S, Chang JY. Volumetric Analysis of Moving Structures in Radiation Treatment Planning, AAPM 2008 Houston, Texas. Medical Physics 35:2834, 2008.
- Titt U, Zhang X, Li Y, Mirkovic D, Sawakuchi G, Mohan R. Monte Carlo Study of Distal Edge Degradation in Proton Therapy Due to Heterogeneities. Proof of Principle with a Case Study, AAPM 2008 Houston, Texas. Medical Physics 35:2798, 2008.
- Kang Y, Mirkovic D, Dong L. Sensitivity of Proton and Photon Plans to the Intra- and Inter-Fractional Changes in Patient's Anatomy, AAPM 2007 Minneapolis, Minnesota. Medical Physics 34:2390, 2007.
- Newhauser W, Fontenot J, Zheng Y, Taddei P, Mirkovic D, Titt U, Zhu X, Sahoo N, Schaffner B, Langenegger A, Koch N, Zhang X, Mohan R. A Monte-Carlo Based Dose Engine for Proton Radiotherapy Treatment Planning. Medical Physics 34(6):2406, 2007.
- Taddei P, Fontenot J, Zheng Y, Mirkovic D, Titt U, Newhauser W. Monte Carlo Investigation of Local Shielding to Reduce Stray Radiation Doses to Patients Receiving Proton Therapy, AAPM 2007 Minneapolis, Minnesota. Medical Physics 34(6):2471, 2007.
- Newhauser W, Fontenot J, Zheng Y, Taddei P, Mirkovic D, Titt U, Zhu X, Sahoo N, Schaffner B, Langenegger A, Koch N, Zhang X and Mohan R. A Monte-Carlo Based Dose Engine for Proton Radiotherapy Treatment Planning, AAPM 2007 Minneapolis, Minnesota. Medical Physics 34:2406, 2007.
Grant & Contract Support
Title: | Scalable Scientific Software Libraries |
Funding Source: | National Science Foundation (NSF) |
Role: | Senior Investigator |
Title: | Los Alamos Computer Science Institute |
Funding Source: | Department of Energy (DOE) |
Role: | Investigator |
Title: | Grid Application Development Software |
Funding Source: | National Science Foundation (NSF) |
Role: | Investigator |
Title: | FFT library Development |
Funding Source: | Intel Corporation |
Role: | Co-Investigator |
Title: | Nonlinear Filtering Approaches to Multitarget Tracking |
Funding Source: | ONR (Office of Naval Research |
Role: | Co-Investigator |
Title: | ISU Startup Grant |
Funding Source: | Iowa State University |
Role: | Principal Investigator |
Title: | Intensity Modulated Particle Therapy |
Funding Source: | Sister Institution Network Fund |
Role: | Co-Investigator |
Title: | In-Situ PET Imaging for Adaptive Proton Therapy |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Collaborator |
Title: | Moving proton therapy towards its full potential by using fast Monte Carlo techniquies |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Principal Investigator-MDACC |
Title: | The future of particle therapy: Physics and biology of light ions |
Funding Source: | UTMDACC - The Center for Radiation Oncology Research |
Role: | Co-Investigator |
Title: | Improving the clinical effectiveness and understanding of the biophysical basis - Project 3: Assessing accuracy of proton therapy and understanding the impact of physical and biophysical factors on its outcomes |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Core B - Clinical & Research Support at MDACC |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Understanding Biological and Physical Factors Affecting Response to Proton Therapy to Improve its Clinical Effectiveness |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Principal Investigator |
Title: | Mapping Proton RBE Variability Using Automated Biology and Monte Carlo Techniques |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Advancing Linear Energy Transfer Models for Biologically Optimized Proton Therapy |
Funding Source: | MDACC-IRG |
Role: | Co-Investigator |
Title: | Optimizing Proton Therapy - Core C: Statistics, Data Exchange, Management and Support |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Optimizing Proton Therapy - Core B: Clinical and Computational Support |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | The future of particle therapy: Physics and biology of light ions |
Funding Source: | Sister Institution Network Fund Application |
Role: | Co-Investigator |
Patient Reviews
CV information above last modified August 28, 2024