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Edward I Chang, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Plastic Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2003 New York University School of Medicine, New York, NY, MD, Medicine, Honors Cell Biology
1999 University of Pennsylvania, Philadelphia, PA, BA, Summa Cum Laude, Major, Minor Chemistry and Anthropology

Postgraduate Training

7/2010-6/2011 Clinical Fellowship, Microvascular Reconstructive Surgery Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX, Charles E. Butler, MD, FACS
7/2008-6/2010 Clinical Residency, Plastic Surgery, University of California, San Francisco, San Francisco, CA
6/2006-6/2008 Research Fellowship, Plastic Surgery, Stanford University, Palo Alto, CA
6/2004-6/2006 Clinical Residency, General Surgery, University of California, San Francisco, San Francisco, CA
6/2003-6/2004 Clinical Internship, General Surgery, University of California, San Francisco, San Francisco, CA


Other Appointments/Responsibilities

Operating Room Liaison, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2014-present
Clinical Specialist, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2010-6/2011
Research Assistant, NYU Laboratory for Microvascular Research and Tissue Engineering, New York, NY, 3/2002-5/2003
Anatomy Fellow and Tutor, NYU School of Medicine Department of Anatomy, New York, NY, 7/2000-12/2000
Research Assistant, Wistar Institute, Philadelphia, PA, 8/1997-5/1999

Institutional Committee Activities

Director, Annual Microsurgical Skills Course, 2014-present
Representative, Faculty Senate Representative, Department of Plastic Surgery, 2014-present
Member, Travel Advisory Committee Task Force, 12/2013-present
Member, Global International Service, 2013-present
Member, Morgan Welch Inflammatory Breast Cancer Comprehensive Care Center, 2013-present
Member, Head & Neck Quality Improvement Group, 2013-present
Ad Hoc Reviewer, Clinical Research Committee, 2012-2013
Member, Patient Safety & Pharmacy, Dept. Plastic Surgery Heparin Order Form, 2011-2012

Honors and Awards

2012 Best Case/Best Save Award, The University of Texas MD Anderson Cancer Center Plastic Surgery
2011 Best Resident/Fellow Paper Award, Chang Gund Mayo Clinic Symposium in Reconstructive Surgery
2010 Best Microsurgical Paper, Senior Residents Conference
2009 Best Scientific Research Paper, ASRM
2008 Best Basic Science Paper, PS Research Symposium, Stanford University
2008 Young Investigator Award, Wound Healing Society
2007 Gingrass Award Recipient, Plastic Surgery Research Council
2003 Abraham Ellis Clinical Research Grant, New York University School of Medicine
2003 ACP ASIM Regional Clinical Research Abstract and Poster First Place, New York University School of Medicine
2003 Founder NYU Chapter Operation Smile, New York University School of Medicine
2003 Inductee to Delta Chapter of Alpha Omega Alpha Honor Society, Alpha Omega Alpha Honor Society
2003 Julius R. Krevans Surgery Intern of the Year Award, University of California, San Francisco
2003 Milton B. Rosenbluth Foundation Clinical Research Grant, New York University School of Medicine
2002-2003 J.T. Tai Foundation Scholarship, New York University School of Medicine
2002-2003 NYU School of Medicine Honors Program, New York University School of Medicine
2002 ACP ASIM Regional Clinical Research Abstract and Poster Winner, New York University School of Medicine
2001 Medicine Clerkship Essay Award, New York University School of Medicine
1999 Phi Beta Kappa Honor Society, University of Pennsylvania
1998 Golden Key National Honor Society, University of Pennsylvania
1995-1999 Dean's List, University of Pennsylvania

Professional Memberships

American College of Surgeons
Associate Candidate, 2014-present
Resident Member, 2003-2014
American Society of Maxillofacial Surgeons
Resident Member, 2007-present
American Society of Plastic Surgeons
Candidate Member, 2014-present
Member, Quality and Performance Measurement Committee, 2014-present
Resident Member, 2008-2014
American Society of Reconstructive Microsurgery
Active Member, 2014-present
Godina Committee, YMG Representative, 2014-present
Member, Young Microsurgeons Group Committee, 2014-present
Member Elect, 2010-2014
Houston Society of Plastic Surgeons, Houston, TX
Member, 7/2014-present
Plastic Surgery Research Council
Member International Federation of Adipose Therapeutics and Science, 2014-present
Active Member, 2013-present
Member, Membership Committee, 2013-present
Resident Member, 2009-2011

Selected Publications

Peer-Reviewed Original Research Articles

1. Scaglioni MF, Suami H, Brandozzi G, Dusi D, Chang EI. Cadaveric dissection and clinical experience with 20 consecutive tunneled pedicled superficial temporal artery perforator (STAP) flaps for ear reconstruction. Microsurgery, 9/2014.
2. Chang EI, Chang EI, Soto-Miranda MA, Zhang H, Nosrati N, Crosby MA, Reece GP, Robb GL, Chang DW. Comprehensive evaluation of risk factors and management of impending flap loss in 2138 breast free flaps. Ann Plast Surg. e-Pub 7/2014.
3. Lee PS, Sedrak P, Guha-Thakurta N, Chang EI, Ginsberg LE, Esmaeli B, Debnam JM. Imaging findings of recurrent tumors after orbital exenteration and free flap reconstruction. Ophthal Plast Reconstr Surg 30(4):315-321, 7/2014.
4. Sedrak P, Lee PS, Guha-Thakurta N, Chang EI, Ginsberg LE, Esmaeli B, Debnam JM. Magnetic resonance imaging findings of myocutaneous and fasciocutaneous flaps used for reconstruction of orbital exenteration defects. Ophthal Plast Reconstr Surg 30(4):328-336, 7/2014.
5. Chang EI, Fearmonti RM, Chang DW. Cephalic vein transposition versus vein grafts for venous outflow in free-flap breast reconstruction. Plast Reconstr Surg GO 2(5):e141-e157, 5/2014.
6. Scaglioni MF, Chang EI, Gur E, Barnea Y, Meller I, Kollander Y, Bickels J, Dadia S, Zaretski A. The role of the fibula head flap for joint reconstruction after osteoarticular resections. J Plast Reconstr Aesthet Surg 67(5):617-623, 5/2014.
7. Chang EI, Chang EI, Soto-Miranda MA, Zhang H, Nosrati N, Robb GL, Chang DW. Comprehensive analysis of donor-site morbidity in abdominally based free flap breast reconstruction. Plast Reconstr Surg 132(6):1383-1391, 12/2013.
8. Zang M, Zhang Q, Chang EI, Mathur AB, Yu P. Decellularized tracheal matrix scaffold for tracheal tissue engineering: in vivo host response. Plast Reconstr Surg 132(4):549e-559e, 10/2013.
9. Chang EI, Chang EI, Soto-Miranda MA, Nosrati N, Robb GL, Chang DW. Demystifying the use of internal mammary vessels as recipient vessels in free flap breast reconstruction. Plast Reconstr Surg 132(4):763-768, 10/2013.
10. Chang EI, Lamaris GA, Chang DW. Simultaneous contralateral reduction mammoplasty or mastopexy during unilateral free flap breast reconstruction. Ann Plast Surg 71(2):144-148, 8/2013.
11. Chang EI. My first 100 consecutive microvascular free flaps: pearls and lessons learned in first year of practice. Plast Reconstr Surg GO 1(4):1-8, 7/2013.
12. Auerbach LJ, Galvez MG, De Clerck BK, Glotzbach J, Wehner MR, Chang EI, Gurtner GC, Auerbach PS. A novel mouse model for frostbite injury. Wilderness Environ Med 24(2):94-104, 6/2013.
13. Chang EI, Selber JC, Chang EI, Nosrati N, Zhang H, Robb GL, Chang DW. Choosing the optimal timing for contralateral symmetry procedures following unilateral free flap breast reconstruction. Ann Plast Surg. e-Pub 6/2013.
14. Chang EI, Hanasono MM, Clemens M, Garvey P, Zhang H, Selber JC. A prospective study of transit time flow volume (TTFV) measurement for intraoperative evaluation and optimization of free flaps for oncologic reconstruction. Plast and Reconstr Surg 131(2):270-281, 2/2013.
15. Chang EI, Clemens MW, Garvey PB, Skoracki RJ, Hanasono MM. Cephalometric analysis for microvascular head and neck reconstruction. Head & Neck 34(11):1607-1614, 11/2012. e-Pub 1/2012.
16. Garvey PB, Chang EI, Selber JC, Skoracki RJ, Madewell JE, Lui J, Yu P, Hanasono, MM. A prospective study of preoperative computed tomographic angiographic mapping of free fibula osteocutaneous flaps for head and neck reconstruction. Plast Reconstr Surg 130(4):541e-549e, 10/2012.
17. Selber JC, Chang EI, Liu J, Suami H, Adelman DM, Garvey P, Hanasono MM, Butler CE. Tracking the learning curve in microsurgical skill acquisition. Plast Reconstr Surg 130(4):550e-557e, 10/2012.
18. Zang M, Zhang Q, Chang EI, Mathur AB, Yu P. Decellularized tracheal matrix scaffold for tissue engineering. Plast Reconstr Surg 130(3):532-540, 9/2012.
19. Chang EI, Peled AW, Lin C, Foster RD, Zeidler KR, Ewing CA, Alvarado M, Hwang ES, Esserman LJ. Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction in large breasted patients as an alternative to mastectomy. Ann Surg 255(6):1151-1157, 6/2012.
20. Samant M, Chang EI, Petrungaro J, Ver Halen JP, Yu P, Skoracki RJ, Chang DW. Reconstruction of massive oncologic defects following extremity amputation: A 10 year experience. Ann Plast Surg 68(5):467-471, 5/2012.
21. Chang EI, Leon P, Hoffman WY, Schmidt BL. Quality of life for patients requiring surgical resection and reconstruction for mandibular osteoradionecrosis: 10 year experience at the University of California San Francisco. Head Neck 34(2):207-212, 2/2012. e-Pub 5/2011. PMID: 21584893.
22. Clemens MW, Chang EI, Oates SD, Lewis V, Chang DW. Composite extremity and trunk reconstruction with vascularized fibula flap in post-oncologic bone defects: A 10 year experience. Plast Reconst Surg 129(1):170-178, 1/2012.
23. Yu P, Chang EI, Selber JC, Hanasono, MM. Perforator patterns of the ulnar artery perforator flap. Plast Reconstr Surg 129(1):213-220, 1/2012.
24. Chang EI, Galvez MG, Glotzbach J, Hamou CD, El-ftesi S, Sommer KM, Abilex OJ, Rajadas J. Longaker MT, Fuller GG, Gurtner GC. Novel engineered thermoreversible nanoparticle poloxamer gel for vascular anastomosis. Nature Med 17(9):1147-1152, 8/2011.
25. Chang EI, Carlson GA, Vose JG, Huang EJ, Yang GP. Comparative healing of rat fascia following incision with three surgical instruments. J Surg Res 167(1):e47-54, 5/1/2011. e-Pub 1/22/2011. PMID: 21324486.
26. Yu P, Chang EI, Hanasono MM. Design of reliable skin paddle for fibula osteocutaneous flap: perforator anatomy revisited. Plast Reconstr Surg 128(2). e-Pub 4/2011. PMID: 21502907.
27. Chang EI, Galvez MG, Padilla BE, Freise CE, Foster RD, Hoffman WY. Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation. Arch Surg 146(1):21-25, 1/2011. PMID: 21242441.
28. Gruber RP, Chang EI, Buchanan E. Suture techniques in rhinoplasty. Clin Plast Surg 37(2):231-243, 4/2010.
29. Thangarajah H, Vial IN, Grogan RH, Yao D, Shi Y, Januszyk M, Galiano RD, Chang EI, Galvez MG, Glotzbach JP, Wong VW, Brownlee M, Gurtner GC. HIF-1alpha dysfunction in diabetes. Cell Cycle 9(1):75-79, 1/2010. PMID: 20016290.
30. Loh SA, Carlson GA, Chang EI, Huang E, Palanker D, Gurtner GC. Comparative healing of surgical incisions created by the PEAK PlasmaBlade, conventional electrosurgery, and a scalpel. Plast Reconstr Surg 124(6):1849-59, 12/2009. PMID: 19952641.
31. Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A 106(32):13505-10, 8/11/2009. e-Pub 7/28/2009. PMCID: PMC2726398.
32. Hopper RA, VerHalen JP, Tepper O, Mehrara BJ, Detch R, Chang EI, Baharestani S, Simon BJ, Gurtner GC. Osteoblasts stimulated with pulsed electromagnetic fields increase HUVEC proliferation via a VEGF-A independent mechanism. Bioelectromagnetics 30(3):189-97, 4/2009. PMID: 19194859.
33. Chang EI, Bonillas RG, El-ftesi S, Chang EI, Ceradini DJ, Vial IN, Chan DA, Michaels J, Gurtner GC. Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds. FASEB J 23(3):906-15, 3/2009. e-Pub 11/10/2008. PMCID: PMC2653982.
34. El-Ftesi S, Chang EI, Longaker MT, Gurtner GC. Aging and diabetes impair the neovascular potential of adipose-derived stromal cells. Plast Reconstr Surg 123(2):475-85, 2/2009. PMCID: PMC2878769.
35. Loh SA, Chang EI, Galvez MG, Thangarajah H, El-ftesi S, Vial IN, Lin DA, Gurtner GC. SDF-1 alpha expression during wound healing in the aged is HIF dependent. Plast Reconstr Surg 123(2 Suppl):65S-75S, 2/2009. PMID: 19182665.
36. Thangarajah H, Vial IN, Chang E, El-Ftesi S, Januszyk M, Chang EI, Paterno J, Neofytou E, Longaker MT, Gurtner GC. IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells 27(1):266-74, 1/2009. PMID: 18974212.
37. Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, Simon BJ, Gurtner GC. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 121(1):130-41, 1/2008. PMID: 18176216.
38. Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 116(24):2818-29, 12/11/2007. e-Pub 11/26/2007. PMID: 18040029.
39. Chang EI, Chang EI, Thangarajah H, Hamou C, Gurtner GC. Hypoxia, hormones, and vascular progenitors in hemangioma. Lymphatic Research & Biology 5(4):237-244, 12/2007.
40. Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, Holmes JW, Longaker MT, Yee H, Gurtner GC. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 21(12):3250-61, 10/2007. e-Pub 5/15/2007. PMID: 17504973.
41. Chang EI, Foster RD, Hansen SL, Jazayeri L, Patti MG. Autologous tissue reconstruction of ventral hernias in morbidly obese patients. Arch Surg 142(8):746-9; discussion 749-51, 8/2007. PMID: 17709728.
42. Singh SP, Chang EI, Gossain AK, Mehara BJ, Galiano RD, Jensen J, Longaker MT, Gurtner GC, Saadeh PB. Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts. J Am Coll Surg 204(3):426-34, 3/2007. e-Pub 1/30/2007. PMID: 17324777.
43. Cetrulo CL, Knox KR, Brown DJ, Ashinoff RL, Dobryansky M, Ceradini DJ, Capla JM, Chang EI, Bhatt KA, McCarthy JG, Gurtner GC. Stem cells and distraction osteogenesis: endothelial progenitor cells home to the ischemic generate in activation and consolidation. Plast Reconstr Surg 116(4):1053-64; discussion 1065-7, 9/15/2005. PMID: 16163094.
44. Tepper OM, Callaghan MJ, Chang EI, Galiano RD, Bhatt KA, Baharestani S, Gan J, Simon B, Hopper RA, Levine JP, Gurtner GC. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 18(11):1231-3, 8/2004. e-Pub 6/18/2004. PMID: 15208265.

Book Chapters

1. Chang EI, Mueller JA, Chang DW. In: Free Tissue Transfer Rehabilitation Medicine Quick Reference Cancer. Demos Medical: New York, 2014.
2. Chang EI, Sacks JM, Kupferman M. Plastic Surgery 3rd. In: Carcinoma of Upper Acrodigestive Tract. Ed(s) P Neligan. Elsevier, 2013.
3. Chang EI, Skoracki RJ. Silicone Breast Implants: Facts and Controversies. In: Advanced Therapy of Breast Disease, Third. People's Medical Publishing House - USA: Shelton, Connecticut, 2012.

Grant & Contract Support

Title: Examining role of HIF1a mediated neovascularization in aging
Funding Source: NIH Supplemental
Role: Postdoctoral Fellow
Principal Investigator: Gurtner GC
Duration: 2009 - 2011
Title: Developing a novel technique for sutureless microvascular anastomosis with thermoreversible gels and adhesives
Funding Source: Stanford University
Role: Postdoctoral Fellow
Principal Investigator: Gurtner GC
Duration: 2006 - 2008

Last updated: 12/16/2014