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Elizabeth Gardner Grubbs, M.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Hermann Pressler Drive
Unit Number: 1484
Houston, TX 77030-4008
Room Number: FCT17.5058

Education & Training

Degree-Granting Education

1999 Duke University School of Medicine, Durham, NC, MD, Medicine
1995 Duke University, Durham, NC, BS, Arts in Women's Studies
1995 Duke University Medical Center, Durham, NC, BS, magna cum laude, Science in Biology

Postgraduate Training

2006-2008 Clinical Fellowship, Surgical Oncology Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX
6/1999-6/2006 Clinical Residency, Duke University Medical Center, Durham, NC

Selected Publications

Peer-Reviewed Original Research Articles
1. Pettiford J, Erasmus J,Grubbs EG, Perrier ND. Dysphagia lucoria: Consideration for the endocrine surgeon. Surgery 147(6):890-2, 6/2010. e-Pub 12/2009. PMID: 20004435.
2. Waguespack SG, Rich T,Grubbs EG, Ying AK, Perrier ND, Ayala-Ramirez M, Jimenez C. A Current Review of the Etiology, Diagnosis, and Treatment of Pediatric Pheochromocytoma and Paraganglioma. J Clin Endocrinol Metab 95(5):2023-2037, 5/2010. e-Pub 3/2010. PMID: 20215394.
3. Morris GS,Grubbs EG, Hearon CM, Gantela S, Lee JE, Evans DB, Holmes HM, Busaidy NL, Jimenez C, Perrier ND. Parathyroidectomy improves functional capacity in "asymptomatic" older patients with primary hyperparathyroidism: a randomized control trial. Ann Surg 251(5):832-7, 5/2010. PMID: 20395857.
4. Grubbs EG, Callender GG, Xing Y, Perrier ND, Evans DB, Phan AT, Lee JE. Recurrence of Adrenal Cortical Carcinoma Following Resection: Surgery Alone Can Achieve Results Equal to Surgery Plus Mitotane. Ann Surg Oncol 17(1):263-70, 1/2010. e-Pub 10/2009. PMID: 19851811.
5. Grubbs EG, Lee JE. Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a revised TNM classification. Cancer 115(24):5847, 12/2009. e-Pub 10/2009. PMID: 19827149.
6. Perrier ND, Balachandran D, Wefel JS, Jimenez C, Busaidy N, Morris GS, Dong W, Jackson E, Weaver S, Gantela S, Evans DB, Grubbs EG, Lee JE. Prospective, randomized, controlled trial of parathyroidectomy versus observation in patients with "asymptomatic" primary hyperparathyroidism. Surgery 146(6):1116-22, 12/2009. e-Pub 10/2009. PMID: 19879613.
7. Marshall CL, Lee JE, Xing Y, Perrier ND, Edeiken BS, Evans DB, Grubbs EG . Routine pre-operative ultrasonography for papillary thyroid cancer: Effects on cervical recurrence. Surgery 146(6):1063-72, 12/2009. PMID: 19958933.
8. Callender GG, Kennamer DL, Grubbs EG, Lee JE, Evans DB, Perrier ND. Posterior Retroperitoneoscopic Adrenalectomy. Adv Surg 43(1):147-157, 9/2009. PMID: 19845175.
9. Callender GG, Grubbs EG, Vu T, Hofstetter WL, Fleming JB, Woodburn KL, Lee JE, Evans DB, Perrier ND. The fallen one: the inferior parathyroid gland that descends into the mediastinum. J Am Coll Surg 208(5):887-93; discussion 893-5, 5/2009. PMID: 19476855.
10. Grubbs EG, Mittendorf EA, Perrier ND, Lee JE. Gamma probe identification of normal parathyroid glands during central neck surgery can facilitate parathyroid preservation. Am J Surg 196(6):931-5; discussion 935-6, 12/2008. PMID: 19095112.
11. Grubbs EG, Rafeeq S, Jimenez C, Feng L, Lee JE, Evans DB, Perrier ND. Preoperative Vitamin D Replacement Therapy in Primary Hyperparathyroidism: Safe and Beneficial? Surgery 144(6):852-8, 12/2008. PMID: 19040987.
12. Perrier ND, Kennamer DL, Bao R, Jimenez C, Grubbs EG, Lee JE, Evans DB. Posterior retroperitoneoscopic adrenalectomy: preferred technique for removal of benign tumors and isolated metastases. Ann Surg 248(4):666-74, 10/2008. PMID: 18936580.
13. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer. Curr Probl Surg 45(3):156-250, 3/2008. PMID: 18346477.
14. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer.In brief. Curr Probl Surg 45(3):149-51, 3/2008. PMID: 18346476.
15. Grubbs EG, Evans DB. Role of lymph node dissection in primary surgery for thyroid cancer. J Natl Compr Canc Netw 5(6):623-30, 7/2007. PMID: 17623613.
16. Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK. Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. Ann Surg Oncol 13(12):1645-54, 12/2006. PMID: 16957968.
17. Ueno T, Ko SH, Grubbs EG, Yoshimoto Y, Augustine C, Abdel-Wahab Z, Cheng TY, Abdel-Wahab OI, Pruitt SK, Friedman HS, Tyler DS. Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine. Mol Cancer Ther 5(3):732-8, 3/2006. PMID: 16546988.
18. Aloia TA. Grubbs EG. Onaitis M. Mosca PJ. Cheng TY. Seigler H. Tyler DS. Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response. Archives of Surgery 140(11):1115-20, 11/2005.
19. Ueno T, Ko SH, Grubbs EG, Pruitt SK, Friedman HS, Tyler DS. Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma. Am J Surg 188(5):532-7, 11/2004. PMID: 15546565.
20. Grubbs EG, Abdel-Wahab O, Cheng TY, Abdel-Wahab Z, Peterson B, Pruitt SK, Colvin OM, Friedman HS, Tyler DS. In-transit Melanoma: The Role of Alkylating Agent Resistance in Regional Therapy. J Am Coll Surg 199(3):419-27, 9/2004. PMID: 15325612.
21. Abdel-Wahab OI, Grubbs EG, Vigliani BL, Cheng Ty, Ueno T, Ko S, Rabbani Z, Curtis S, Pruitt SK, Dewhirst MW, Tyler DS. The role of hyperthermia in regional alkylating agent chemotherapy. Clinical Cancer Research 10(17):5919-29, 9/2004.
22. Grubbs EG, Ueno T, Abdel-Wahab O, Cheng TY, Pruitt SK, Colvin MO, Friedman HS, Tyler DS. Modulation of resistance to regional chemotherapy in the extremity melanoma model. Surgery 136(2):210-8, 8/2004.
23. Cheng TY, Grubbs EG, Abdul-Wahab O, Leu SY, Hung CF, Petros W, Slois T, Fedrau R, Pruitt S, Colvin M, Freidman H, Tyler DS. Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion. American Journal of Surgery 186(5):460-7, 11/2003.
24. Reynolds JD, Grubbs EG, Dexter F, Punnahitananda S, Dense TA, Penning DH. Acute cord occlusion increases blood ionized magnesium concentration in preterm fetal sheep during maternal magnesium sulfate exposure. Can J Physiol Pharmacol 78(4):301-6, 4/2000. PMID: 10772057.
25. Reynolds JD, Grubbs EG, Dexter F, Atkins BL, Dense TA, Penning DH. Hypoxia increases blood ionized magnesium concentration in preterm fetal sheep during maternal magnesium sulfate exposure. Canadian Journal of Physiology and Pharmacology 78:301-6, 2000.

Abstracts
1. Grubbs EG, Xing Y, Callender GG, Perrier ND, Evans DB, Phan AT, Lee JE. Comparison of adrenal cortical carcinoma (ACC) staging systems by combined large database analysis. 2009 IAES Conference, Adelaide, Australia, 9/2009.
2. Grubbs EG, Callender GG, Perrier ND, Phan AT, Lee JE. Mitotane for treatment of advanced adrenal cortical carcinoma(ACC): relationship of drug level and length of treatment to disease progression. 2009 IAES Conference, Adelaide, Australia, 9/2009.
3. Grubbs EG, Marshall CL, Evans DB, Lee JE, Perrier ND, Edeiken BS. Routine Preoperative Ultrasound for Papillary Thyroid Cancer: Long-Term Results in 236 PATIENTS. AAES 30th Annual Meeting, Madison, Wisonsin, 5/2009.
4. Grubbs EG, Mittendorf EA, Phan AT, Perrier ND, Evans DB, Callender GG, Xing Y, Lee JE. Recurrence of Adrenocortical Carcinoma Following Resection: Surgery Alone can Achieve Results Equal to Surgery Plus Mitotane. Society of Surgical Oncology, 62nd Annual Cancer Symposium, 3/2009.
5. Grubbs EG, Mittendorf EA, Evans DB, Perrier ND, Lee JE. Gamma Probe Identification of Normal Parathyroid glands During Central Neck Surgery Can Facilitate Parathyroid Preservation. Am J Surg 196(6):931-5; discussion 935-6, 12/2008. PMID: 19095112.
6. Grubbs EG, Mittendorf EA, Evans DB, Perrier ND, Lee JE. Intraoperative Gamma Probe Identification of Normal Parathyroid Glands During Central Neck Surgery. Montreal, CA 196(6):931-936, 12/2008.
7. Grubbs EG, Lee JE, Rafeeq S, Gagel RF, Jimenez C, Feng L, Perrier ND. Preoperative Vitamin D (VitD) Replacement Therapy in Primary Hyperparathyroidism (PHPT): Safe but Beneficial?. Surgery 144(6):852-858; discussion 852-859, 12/2008.
8. Grubbs EG, Gantela S, Morris GS, Perrier, ND. Parathyroidectomy Improves Functional Capacity in Geriatric Patients (pts) with Seemingly "Asymptomatic" Primary Hyperparathyroidism. Society of Surgical Oncology Annual Meeting, Chicago, IL, 2008.
9. Grubbs EG, Lee JE, Evans DB, Nunez RF, Perrier ND. SPECT/CT is useful in planning incision site for minimally invasive parathyroidectomies (MIP) in treatment of primary hyperparathyroidism (PHPT). British Association of Endocrine and Thyroid Surgeons, 2008.
10. Grubbs EG, Bentley R, Pruitt SK. Sentinel Lymph Node Biopsy in Breast Cancer: How Many Nodes Need to be Removed?. Society of Surgical Oncology Annual Meeting, Washington, DC, 2007.
11. Grubbs EG, Abdel-Wahab Z, Pruitt SK, Tyler DS. Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. Ann Surg Oncol 13(12):1645-54, 12/2006. PMID: 16957968.

Book Chapters
1. Lee JE, Grubbs EG. Adrenocortical Carcinoma. In: McGraw-Hill Manual Endocrine Surgery, 1. Ed(s) Morita SY, Dackiw APB, Zeiger MA. The McGraw-Hill Companies: United States, 392, 2010.
2. Grubbs EG, Nunez R, Iyer RB, Perrier ND. Adrenal Imaging. In: Endocrine Surgery: Principles and Practice. Ed(s) Hubbard JGH, Inabnet WB, Lo C-Y. Springer: London, 343-357, 2009.

Letters to the Editor
1. Lee JE, Grubbs EG. Observations on the ENSAT Staging System. Cancer, 2011.

Last updated: 12/20/2012