Ellen R. Richie, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
A major focus of my research program is to discern the molecular pathways that regulate thymus development and homeostasis. T cell development requires indispensable growth, survival and differentiation signals supplied by thymic epithelial cells (TECs) in the stromal microenvironment. Loss of TECs during age-associated or cytoablative therapy-induced thymus involution reduces thymopoiesis and naive T cell output. The resulting restriction in T cell receptor repertoire diversity of peripheral T cells severely compromises immune responses to newly encountered antigens. We are using various transgenic and knock-out experimental models to identify molecular pathways that can be manipulated to prevent or reverse thymus involution in order to maintain protective T cell immune responsiveness. In another approach to provide a functional thymic microenvironment, we are studying the molecular pathways that commit primitive endodermal progenitors to a TEC fate and regulate differentiation of functional TEC subsets.
We are also investigating the genetic and epigenetic pathways that regulate thymocyte differentiation and thymic lymphoma development. Using an experimental model in which thymic lymphomas are induced by injecting the carcinogen N-methyl-N-nitrosourea (MNU), we have shown that mice expressing a hypomorphic allele of the Polycomb group gene eedhave a partial block in thymocyte differentiation as well as enhanced susceptibility to MNU-induced lymphomagenesis. These data suggest that eedfunctions as a tumor suppressor gene in inhibiting thymic lymphoma. We are currently investigating the mechanisms by which eedregulates T cell development and lymphomagenesis.
Education & Training
Degree-Granting Education
| 1970 | The University of Texas, Austin, Texas, US, Immunochemistry, Ph.D |
| 1967 | The University of Texas, Austin, Texas, US, Microbiology-major, Chemistry and English-minors, BA |
Postgraduate Training
| 1970-1972 | Research Fellowship, Baylor College of Medicine, Division of Experimental Biology, Houston, Texas |
Experience & Service
Academic Appointments
Associate Professor, Department of Science Park-Research Division, The University of Texas System Cancer Center, Smithville, TX, 1982 - 1991
Associate Professor, Department of Pediatrics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX, 1979 - 1982
Assistant Professor, Department of Pediatrics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX, 1974 - 1979
Assistant Professor, Department of Division of Experimental Biology, Baylor College of Medicine, Houston, TX, 1972 - 1974
Instructor, Department of Division of Experimental Biology, Baylor College of Medicine, Houston, TX, 1971 - 1972
Administrative Appointments/Responsibilities
Associate Director of Education, Department of Science Park-Research Division, The University of Texas, MD Anderson Cancer Center, Smithville, TX, 1999 - 2018
Director, Department of Flow Cytometry Core, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX, 1998 - Present
Assistant Dean, The University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Houston, TX, 1983 - 2021
Other Appointments/Responsibilities
Member, American Association of Immunologists Finance Subcommittee, Bethesda, MD, 2005 - 2008
Chair, American Association of Immunologists Subcommittee on the Status of Women, Bethesda, MD, 2001 - 2004
Member, American Association of Immunologists Subcommittee on the Status of Women, Bethesda, MD, 1998 - 2001
Institutional Committee Activities
Co-Chair, Community Task Force, GSBS, 2017 - 2017
Member, Community Committee, GSBS - G & E Program, 2017 - 2018
Member, Reshaping GSBS: Community Working Group, 2016 - 2017
Co-Director, Molecular Carcinogenesis Program, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 2013 - 2014
Director, Molecular Carcinogenesis Program, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 2012 - 2013
Faculty Mentor, CPRIT Scholar Training Grant Committee, 2010 - 2014
Member, MD Anderson Graduate Education Committee, 2008 - 2012
Ex-officio Member, GSBS Executive Committee, 2000 - 2021
Program Director, Molecular Carcinogenesis Program, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1999 - 2010
Co-Chairman, Immunology Department Chair Search Committee, 1999 - 2000
Member, Curriculum Committee, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1997 - 2000
Faculty Senator, Faculty Senator, 1994 - 1995
Member, Shared Resources Committee, 1992 - 2000
Director, Cooperative Science Education Program with Smithville High School, 1990 - 2009
Chair, Graduate Studies Committee, 1989 - 2000
Member, Steering Committee for Immunology Program, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1989 - 1991
Member, Institutional Research Grant Committee, The University of Texas, MD Anderson Cancer Center, 1989 - 1991
Member, Admissions Committee, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1987 - 1990
Chairperson, Postdoctoral Training Committee, The University of Texas System Cancer Center, Science Park, 1984 - 2009
Member, Faculty Classification Committee, 1981 - 1982
Member, Student Affairs Committee, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1980 - 1982
Member, Basic Science Board, 1980 - 1982
Coordinator, Graduate Program for Immunology, 1979 - 1982
Member, Immunology Program Steering Committee, 1979 - 1980
Member, Internal Advisory Board for Program Development, 1978 - 1980
Chairperson, Institutional Research Grant, Committee, 1977 - 1978
Member, Academic Standards Committee, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences, Houston, Texas, 1976 - 1979
Honors & Awards
| 2024 | Distinguished Fellow of AAI, American Association of Immunologists |
| 2001 | Reappointed to the GSBS Faculty with Commendation |
| 2000 | M. D. Anderson Educator of the Month |
| 1998 | M.D. Anderson Cancer Center Faculty Achievement Award in Education |
| 1995 | Julie and Ben Rogers Award for Excellence |
| 1991 | Outstanding Faculty Award |
| 1985 | Dean's Teaching Excellence List |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Larouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, Côté C, Humeau JF, É B, Lanoix J, Durette C, Gendron P, Laverdure JP, Richie ER, Lemieux S, Thibault P, Perreault C. Transposable elements regulate thymus development and function. Elife 12, 2024. e-Pub 2024. PMID: 38635416.
- Srinivasan J, Vasudev A, Shasha C, Selden HJ, Perez E, LaFleur B, Sinari SA, Krueger A, Richie ER, Ehrlich LIR. The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments. Aging Cell 22(8):e13870, 2023. e-Pub 2023. PMID: 37221658.
- Gencel-Augusto J, Su X, Qi Y, Whitley EM, Pant V, Xiong S, Shah V, Lin J, Perez E, Fiorotto ML, Mahmud I, Jain AK, Lorenzi PL, Navin NE, Richie ER, Lozano G. Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program. Cancer Discov 13(5):1230-1249, 2023. e-Pub 2023. PMID: 37067911.
- Lancaster JN, Keatinge-Clay DE, Srinivasan J, Li Y, Selden HJ, Nam S, Richie ER, Ehrlich LIR. Central tolerance is impaired in the middle-aged thymic environment. Aging Cell 21(6):e13624, 2022. e-Pub 2022. PMID: 35561351.
- Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Yi S, Xie H, Orkin SH, Manley NR, Ehrlich LIR, Jiang N, Richie ER. Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Sci Rep 8(1):14335, 2018. e-Pub 2018. PMID: 30254371.
- Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe 21(4):478-493.e7, 2017. e-Pub 2017. PMID: 28407484.
- Gomes AC, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, H-R R, Flavell RA Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 45(6):1219-1231, 2016. e-Pub 2016. PMID: 27913094.
- Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR. Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development 143(21):4027-4037, 2016. e-Pub 2016. PMID: 27633995.
- Lomada D, Jain M, Bolner M, Reeh KA, Kang R, Reddy MC, DiGiovanni J, Richie ER. Stat3 Signaling Promotes Survival and Maintenance of Medullary Thymic Epithelial Cells. PLoS Genet 12(1):e1005777, 2016. e-Pub 2016. PMID: 26789196.
- Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER. Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development 141(15):2950-8, 2014. e-Pub 2014. PMID: 25053428.
- Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol 192(2):630-40, 2014. e-Pub 2014. PMID: 24337745.
- Garfin PM, Min D, Bryson JL, Serwold T, Edris B, Blackburn CC, Richie ER, Weinberg KI, Manley NR, Sage J, Viatour P. Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med 210(6):1087-97, 2013. e-Pub 2013. PMID: 23669396.
- Li J, Zhao Z, Carter C, Ehrlich LI, Bedford MT, Richie ER. Coactivator-Associated Arginine Methyltransferase 1 Regulates Fetal Hematopoiesis and Thymocyte Development. J Immunol 190(2):597-604, 2013. e-Pub 2013. PMID: 23248263.
- Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR. Cell-Autonomous Defects in Thymic Epithelial Cells Disrupt Endothelial-Perivascular Cell Interactions in the Mouse Thymus. PLoS One 8(6):e65196, 2013. e-Pub 2013. PMID: 23750244.
- Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood 120(24):4675-83, 2012. e-Pub 2012. PMID: 22955921.
- Badeaux AI, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, Richie E, Li W, Bedford MT. Loss of the methyl-lysine effector molecule PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem 287(1):429-37, 2012. e-Pub 2012. PMID: 22072714.
- Manley NR, Richie ER, Blackburn CC, Condie BG, Sage J. Structure and function of the thymic microenvironment. Frontiers in Bioscience 16:2461-2477, 2011. e-Pub 2011. PMID: 21622189.
- Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC. EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A 107(30):13414-9, 2010. e-Pub 2010. PMID: 20616004.
- Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem 285(2):1147-52, 2010. e-Pub 2010. PMID: 19897492.
- Rojas P, Benavides F, Blando J, Perez C, Cardenas K, Richie E, Knudsen ES, Johnson DG, Senderowicz AM, Rodriguez-Puebla ML, Conti CJ. Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b). Mol Carcinog 48(6):508-16, 2009. e-Pub 2009. PMID: 18942117.
- Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, Richie ER. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: New tools for analysis of IL-7 expressing cells. Genesis 47(4):281-7, 2009. e-Pub 2009. PMID: 19263498.
- Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER. Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant empryos. Dev Biol 327(1):216-27, 2009. e-Pub 2009. PMID: 19135046.
- Lomada D, Liu B, Coghlan L, Hu Y, Richie ER. Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells. J Immunol 178(2):829-37, 2007. e-Pub 2007. PMID: 17202344.
- Benavides F, Gomez G, Venables-Griffith A, Lambertz I, Flores M, Angel JM, Fuchs-Young R, Richie ER, Conti CJ. Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice. Mol Carcinog 45(7):543-8, 2006. e-Pub 2006. PMID: 16479612.
- Zamisch M, Moore-Scott B, Su DM, Lucas PJ, Manley N, Richie ER. Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol 174(1):60-7, 2005. e-Pub 2005. PMID: 15611228.
- El Kassar N, Lucas PJ, Klug DB, Zamisch M, Merchant M, Bare CV, Choudhury B, Sharrow SO, Richie E, Mackall CL, Gress RE. A dose effect of IL-7 on thymocyte development. Blood 104(5):1419-27, 2004. e-Pub 2004. PMID: 15155461.
- Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, Richie E, Bedford MT. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem 279(24):25339-44, 2004. e-Pub 2004. PMID: 15096520.
- Benavides F, Zamisch M, Flores M, Campbell MR, Andrew SE, Angel JM, Licchesi J, Sternik G, Richie ER, Conti CJ. Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis. Genes Chromosomes Cancer 35(4):299-310, 2002. e-Pub 2002. PMID: 12378524.
- Klug DB, Carter C, Gimenez-Conti IB, Richie ER. Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol 169(6):2842-5, 2002. e-Pub 2002. PMID: 12218095.
- Angel JM, Richie ER. Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog 33(2):105-12, 2002. e-Pub 2002. PMID: 11813303.
- Richie ER, Schumacher A, Angel JM, Holloway M, Rinchik EM, Magnuson T. The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas. Oncogene 21(2):299-306, 2002. e-Pub 2002. PMID: 11803473.
- Benavides F, Venables A, Poetschke Klug H, Glasscock E, Rudensky A, Gomez M, Martin Palenzuela N, Guenet JL, Richie ER, Conti CJ. The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene. Immunogenetics 53(3):233-42, 2001. e-Pub 2001. PMID: 11398968.
- Poetschke HL, Klug DB, Perkins SN, Wang TT, Richie ER, Hursting SD. Effects of calorie restriction on thymocyte growth, death and maturation. Carcinogenesis 21(11):1959-64, 2000. e-Pub 2000. PMID: 11062154.
- Richie ER, Walker DA. Production and characterization of immature murine T-lymphoma cell lines. Methods Mol Biol 134:177-84, 2000. e-Pub 2000. PMID: 10730257.
- Rodriguez-Puebla ML, LaCava M, Miliani De Marval PL, Jorcano JL, Richie ER, Conti CJ. Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia. Am J Pathol 157(3):1039-50, 2000. e-Pub 2000. PMID: 10980142.
- Gomez G, Clarkin KZ, Kraig E, Infante AJ, Richie ER. TCR v(beta) repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas. Int Immunol 12(3):263-70, 2000. e-Pub 2000. PMID: 10700461.
- Klug DB, Crouch E, Carter C, Coghlan L, Conti CJ, Richie ER. Transgenic expression of cyclin D1 in thymic epithelial precursors promotes epithelial and T cell development. J Immunol 164(4):1881-8, 2000. e-Pub 2000. PMID: 10657637.
- Klug DB, Carter C, Crouch E, Roop D, Conti CJ, Richie ER. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A 95(20):11822-7, 1998. e-Pub 1998. PMID: 9751749.
- Poetschke HL, Klug DB, Walker D, Richie ER. Cross-linking the TCR complex induces apoptosis in CD4+8+ thymocytes in the presence of cyclosporin A. Dev Immunol 5(1):1-15, 1996. e-Pub 1996. PMID: 8828007.
- Robles AI, Larcher F, Whalin RB, Murillas R, Richie E, Gimenez-Conti IB, Jorcano JL, Conti CJ. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sci U S A 93(15):7634-8, 1996. e-Pub 1996. PMID: 8755527.
- Romach E, Moore J, Rummel S, Richie E. Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas. Carcinogenesis 15(10):2275-80, 1994. e-Pub 1994. PMID: 7955066.
- Angel JM, Morizot DC, Richie ER. Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas. Mol Carcinog 7(3):151-6, 1993. e-Pub 1993. PMID: 8098217.
- Angel JM, Moore JL, Pelphrey A, Richie ER. The mouse homolog of the rhombotin (Ttg-1) gene maps on chromosome 7 distal to the beta-globin (Hbb) locus. Mamm Genome 4(5):281-2, 1993. e-Pub 1993. PMID: 8099513.
- Richie ER, McEntire BB, Coghlan L, Poenie M. Murine T-lymphomas corresponding to the immature CD4-8+ thymocyte subset. Dev Immunol 1(4):255-63, 1991. e-Pub 1991. PMID: 1840416.
- Richie ER, Angel JM, Cloyd MW. Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice. J Virol 65(11):5751-6, 1991. e-Pub 1991. PMID: 1656068.
- Stettner SL, Rummel SA, Conti CJ, Richie ER. N-methyl-N-nitrosourea alters thymocyte subset distribution and targets immature CD4-8+ cells for lymphoma development. Cancer Res 51(2):737-40, 1991. e-Pub 1991. PMID: 1898715.
- Riegel JS, Richie ER, Allison JP. Nuclear events after activation of CD4+8+ thymocytes. J Immunol 144(9):3611-8, 1990. e-Pub 1990. PMID: 1970353.
- Angel JM, Morizot DC, Richie ER. Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. J Natl Cancer Inst 81(21):1652-5, 1989. e-Pub 1989. PMID: 2552132.
- Nelson JA, Richie ER, Kandil O, Vidale E, Pan BF. Differential sensitivities of normal and malignant murine lymphocytes to purine nucleosides. Nucleosides and Nucleotides 8(4):569-86, 1989. e-Pub 1989.
- Nairn RS, McIntyre BW, Richie ER, Allison JP. Characterization of env gene recombination in x-ray--induced thymomas of C57BL/6 mice. Mol Carcinog 2(3):126-30, 1989. e-Pub 1989. PMID: 2675902.
- Arden KC, Pathak S, Stettner S, Richie E. Differential silver-positive nucleolus organizer region activity in normal and malignant murine tissues. Cancer Genet Cytogenet 37(1):55-60, 1989. e-Pub 1989. PMID: 2465079.
- Richie ER. N-methyl-N-nitrosourea-induced and spontaneous AKR/J thymic lymphomas express distinct differentiation antigen phenotypes. Leuk Res 12(3):233-42, 1988. e-Pub 1988. PMID: 3367653.
- Richie ER, McEntire B, Phillips J, Allison JP. Altered expression of lymphocyte differentiation antigens on phorbol ester-activated CD4+8+ T cells. J Immunol 140(12):4115-22, 1988. e-Pub 1988. PMID: 3259607.
- Richie ER, Angel JM, McEntire B. N-methyl-N-nitrosourea-induced T-lymphomas of AKR/J mice contain somatically acquired ecotropic-like murine leukemia proviruses. Virology 164(1):211-9, 1988. e-Pub 1988. PMID: 2834870.
- Richie ER, McEntire B, Crispe N, Kimura J, Lanier LL, Allison JP. Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation. Proc Natl Acad Sci U S A 85(4):1174-8, 1988. e-Pub 1988. PMID: 2963339.
- Richie ER, Hilliard JK, Gilmore R, Gillespie DJ. Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. J Reprod Immunol 12(2):137-48, 1987. e-Pub 1987. PMID: 2963123.
- Henkel RD, Richie E, Williams JC. Intracellular transport of high molecular weight intermediates of acid alpha-glucosidase in human fibroblasts. Biochem Biophys Res Commun 132(1):412-7, 1985. e-Pub 1985. PMID: 3904748.
- Ramirez I, van Eys J, Carr D, Coody D, Carter-George P, Washington J, Richie E, Taylor G. Immunologic evaluation in the nutritional assessment of children with cancer. Am J Clin Nutr 41(6):1314-21, 1985. e-Pub 1985. PMID: 3873869.
- Richie ER, Nairn RS, Becker FF. Proviral structure and differentiation antigen phenotype of spontaneous and chemically induced AKR lymphomas. Cancer Res 45(6):2802-6, 1985. e-Pub 1985. PMID: 2985253.
- Humphrey GB, Blackstock R, Falletta JM, Metzgar RS, Richie ER, Pullen DJ, Boyett JM, Shuster JJ, Roper MA, Russell EC, Mahoney DH, Ragab AH. An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study. Cancer 56(8):1995-2000, 1985. e-Pub 1985.
- Lanier LL, Richie ER, Howell AL, Allison JP. Expression of Ly-1 and Ly-2 on a spontaneous AKR B-cell lymphoma. Immunogenetics 17(6):655-9, 1983. e-Pub 1983. PMID: 6602763.
- Howell AL, Richie ER. Phenotypic drift and clonal variation in differentiation antigen expression on AKR T-cell lymphoma lines grown in vitro. Nat Immun Cell Growth Regul 3(3):143-54, 1983. e-Pub 1983. PMID: 6150437.
- Howell AL, Richie ER, Dennison DK, Chan JYH, Allison JP. Individual AKR lymphomas differ in expression of lymphocyte differentiation antigens and terminal deoxynucleotidyl transferase. Dis Markers 1:3-18, 1983. e-Pub 1983.
- Richie ER, Bass R, Meistrich ML, Dennison DK. Distribution of T lymphocyte subsets in human colostrum. J Immunol 129(3):1116-9, 1982. e-Pub 1982. PMID: 6980919.
- Steinmetz KD, Kohl S, Richie ER. Separation of cytotoxic leukocyte populations of human peripheral blood and colostrum of PVP-silica (Percoll) density gradients. J Immunol Methods 42(2):157-70, 1981. e-Pub 1981. PMID: 6263977.
- Nell LJ, Richie ER. Heterogeneity of cell surface receptors and mitogen reactivity of individual spontaneous AKR lymphomas. Exp Hematol 9(6):611-8, 1981. e-Pub 1981. PMID: 6973483.
- Meistrich ML, Nell LJ, Richie ES. Separation of AKR mouse thymus lymphoma from normal thymic cells by centrifugal elutriation. J Immunol Methods 41(3):289-301, 1981. e-Pub 1981. PMID: 7229386.
- Richie ER, Gillespie DJ. Non-T, non-B acute lymphocytic leukemia cells enhance the mitogen induced proliferation of normal lymphocytes. Leuk Res 4(6):629-38, 1980. e-Pub 1980. PMID: 6970863.
- Ramirez I, Richie E, Wang YM, van Eys J. Effect of ascorbic acid in vitro on lymphocyte reactivity to mitogens. J Nutr 110(11):2207-15, 1980. e-Pub 1980. PMID: 7431121.
- Richie ER, Steinmetz KD, Meistrich ML, Ramirez I, Hilliard JK. T lymphocytes in colostrum and peripheral blood differ in their capacity to form thermostable E-rosettes. J Immunol 125(5):2344-6, 1980. e-Pub 1980. PMID: 6968780.
- Mackler BF, Richie E, Swate T. T-cell subpopulation shifts in human cord blood high- and low-affinity E . RFC. Clin Immunol Immunopathol 15(2):238-44, 1980. e-Pub 1980. PMID: 6965470.
- Richie ER, Culbert SJ, Sullivan MP, van Eys J. Complement receptor-positive, sheep erythrocyte receptor-negative lymphoblasts in childhood acute lymphocytic leukemia. Cancer Res 38(11 Pt 1):3616-20, 1978. e-Pub 1978. PMID: 151582.
- Richie ER, Copeland EM III. Relationship between nutrition and immunity: An overview. Cancer Bull 30:74-8, 1978. e-Pub 1978.
- Richie E, Patchen M. Correlation between temperature-stable E-rosette formation and lymphocyte commitment to activation. Clin Immunol Immunopathol 11(1):88-97, 1978. e-Pub 1978. PMID: 699391.
- Richie ER. Immunological characterization of leukemic cells. Cancer Bull 30:160-5, 1978. e-Pub 1978.
- Ota DM, EMrd C, Jr CJ, Richie ER, Jacobson K, Dudrick SJ. The effects of a 10% soybean oil emulsion on lymphocyte transformation. JPEN J Parenter Enteral Nutr 2(2):112-5, 1978. e-Pub 1978. PMID: 575908.
- Mukhopadhyay N, Richie E, Mackler BF, Montgomery JR, Wilson R, Fernbach DJ, South MA. A longitudinal study of T and B lymphocytes from a three-year-old patient with severe combined immunodeficiency (SCID) in 'gnotobiotic protection'. Exp Hematol 6(2):129-34, 1978. e-Pub 1978. PMID: 304811.
- Lotzova E, Richie ER. Promotion of incidence of adenovirus type 12 transplantable tumors by carrageenan, a specific antimacrophage agent. J Natl Cancer Inst 58(4):1171-2, 1977. e-Pub 1977. PMID: 191626.
- Ruppert BL, Richie ER. Phytohemagglutinin response of murine spleen cells during pregnancy and inhibition of normal phytohemagglutinin response by pregnancy or post-partum serum. Exp Hematol 5(1):59-68, 1977. e-Pub 1977. PMID: 832683.
- Mackler BF, O'Neill P, Mukhopadhyay N, Richie E, Montgomery J. Cytotoxic and soluble mediator responses by complement (C3) receptor-bearing lymphocytes from patients with B-cell immunodeficiency diseases. Clin Immunol Immunopathol 6(3):279-88, 1976. e-Pub 1976. PMID: 1086174.
- Mukhopadhyay N, Richie E, Montgomery J, Wilson R, Fernbach DJ, South MA. Peripheral blood T and B cell characteristics in a patient with severe combined immune deficiency (SCID) maintained in a gnotobiotic environment. Exp Hematol 4(1):1-9, 1976. e-Pub 1976. PMID: 56280.
- Richie ER, Monie HJ, Trentin JJ, Taub RN. Inhibition of the graft-versus-host reaction. III. Altered in vivo distribution of spleen cells pretreated with Fab fragments of antithymocyte globulin. Transplantation 19(2):115-20, 1975. e-Pub 1975. PMID: 235162.
- Richie ER, Gallagher MT, Trentin JJ. Inhibition of the graft-versus-host reaction. II. Prevention of acute graft-versus-host mortality by Fab fragments of antilymphocyte globulin. Transplantation 15(5):486-91, 1973. e-Pub 1973. PMID: 4145551.
- Gallagher MT, Richie ER, Trentin JJ. Inhibition of allograft reactivity in vitro and in vivo, by Fab fragments obtained from ALG. Transplant Proc 5(1):869-72, 1973. e-Pub 1973. PMID: 4144466.
- Richie ER, Gallagher MT, Trentin JJ. Prevention of graft-versus-host disease by Fab fragments derived from ALG. Transplant Proc 5(1):873-6, 1973. e-Pub 1973. PMID: 4144467.
- Gallagher MT, Richie ER, Heim LR, Judd KP, Trentin JJ. Inhibition of the graft-versus-host reaction. I. Reduction of the graft-versus-host potential of mouse spleen cells (with a sparing of stem cells) by treatment with antilymphocyte globulin-derived Fab fragments. Transplantation 14(5):597-602, 1972. e-Pub 1972. PMID: 4404282.
- Richie ER, Gallagher MT, Heim LR, South MA, Trentin JJ. Inhibition of the mixed lymphocyte reaction with fab fragments from anti-human ALG. Proc Soc Exp Biol Med 140(3):916-9, 1972. e-Pub 1972. PMID: 5039391.
- Richie ER, Grote D, Mandy WJ. A new serum factor in normal rabbits. 8. Isolation and characterization of a buried antigenic IgG determinant. J Immunol 108(6):1482-90, 1972. e-Pub 1972. PMID: 4113174.
- Richie ER, Woolsey ME, Mandy WJ. A new serum factor in normal rabbits. VI. Reaction with buried determinants of IgG exposed sequentially with CNBr, pepsin and papain. J Immunol 104(4):984-91, 1970. e-Pub 1970. PMID: 4910057.
- Kang SW, Helm BR, Lau KS, Liu Q, Richie ER, Hale LP, Manley NR. Insulin-like growth factor 2 (IGF2) as a Foxn1-independent driving force of exponential expansion in neonatal thymus. Science Immunology.
Invited Articles
- Srinivasan J, Lancaster JN, Singarapu N, Hale LP, Ehrlich LIR, Richie ER. Age-related changes in thymic central tolerance. Front Immunol 12:676236, 2021. e-Pub 2021. PMID: 33968086.
Manuals, Teaching Aids, Other Teaching Publications
- . Students Acquire Academic Language and Learn Science Utilizing Technology, Journeys in Life Science, Adventures in Discovery Park, 1998.
Other Articles
- Richie ER, Angel JM, Rinchik EM Tlag1, a novel murine tumor susceptibility gene that regulates MNU-induced thymic lymphoma development. Prog Clin Biol Res 395:23-32, 1996. PMID: 8895981.
- Shitara T, Sullivan MP, Brewer ED, Kohl S, Richie E, Butler JJ Hodgkin's disease complicated by nephrotic syndrome. New clinical observations on the response of both diseases to radiotherapy to the neck. Am J Pediatr Hematol Oncol 3(2):177-81, 1981. PMID: 7304860.
- Richie ER, Sullivan MP, van Eys J A unique surface marker profile in T-cell acute lymphocytic leukemia. Blood 55(4):702-5, 1980. PMID: 6444535.
Book Chapters
- Nowell CS, O'Neill K, Rouse P, Henderson T, Richie ER, Manley NR, Blackburn CC. Thymus and Parathyroid Organogenesis. In: Principles of Tissue Engineering, 2020.
- O'Neill K, Nowell CS, Richie E, Manley NR, Blackburn CC. Thymus and Parathyroid Organogenesis. In: Principles of Tissue Engineering, 2016.
- Bain V, Richie ER. Identifying the spatial relationships of thymic stromal and thymocyte subsets by immunofluorescence analysis. In: Methods Mol Biol, 75-85, 2016.
- Manley NR, Richie ER, Blackburn CC, Condie BG, Sage J. Structure and function of the thymic microenvironment. In: Front Biosci (Landmark Ed), 2461-77, 2011.
- Nowell CS, Richie E, Manley NR, Blackburn CC. Thymus and parathyroid organogenesis. In: Principles of Tissue Engineering. 3. Elsevier/Academic Press, 647-62, 2008.
- Richie ER, Walker DA. Production and characterization of immature murine T-lymphoma cell lines. In: T Cell Protocols: Development and Activation. Methods in Molecular Biology, Volume 134. Humana Press, 177-84, 2000.
- Richie ER, Angel JM, Rinchik EM. Tlag1, a novel murine tumor susceptibility gene that regulates MNU-induced thymic lymphoma development. In: Genetics and Susceptibility: Impact on Risk Assessment. Wiley Liss, 23-32, 1996.
- Richie E. Lymphocyte subsets in colostrum. In: Human Milk in Infant Nutrition and Health. Charles C. Thomas Publishing Co, 174-89, 1987.
- Lanier LL, Walker EB, Richie ER, Warner NL. Murine hematopoietic cell tumors: Model for analyses of cellular differentiation. In: B and T Cell Tumors, UCLA Symposium on Molecular and Cellular Biology, Volume 24. Fox Acad Press, 1982.
- Richie ER, Frankel LS. Impact of the new nosology in acute lymphocytic leukemia. In: Status of Curability of Childhood Cancers. Raven Press, 117-87, 1980.
- Richie ER, Copeland EM. Nutrition and immunity. In: Nutrition and Cancer, 55-69, 1979.
- South MA, Montgomery JR, Richie ER, Mukhopadhyay N, Criswell BS, Mackler BF, De Frazio SR, Bealmear P, Heim LR, Trentin JJ, Dreesman GR, O'Neill P. A special report: Four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth IV. Immunologic studies. In: Pediatric Research. Williams and Wilkins Company, 71-8, 1977.
- Richie ER. Biomedical Research: For the patient or on the patient?. In: The Truly Cured Child. University Park Press, 27-36, 1977.
Letters to the Editor
- Newkirk MM, Richie E, Lunney JK. Advancing women scientists: the immunology experience. Nat Immunol 6: 855, 2005.
Selected Presentations & Talks
International Presentations
- 2023. Speaker. Conference. ThymOz 2023 International Conference. Heron Island, AU.
- 2018. Speaker. Conference. 8th Thymoz International Conference. Heron Island, AU.
- 2017. Speaker. Conference. 7th International Workshop of Kyoto T Cell Conference. Kyoto, JP.
- 2016. Speaker. Conference. ThymUS International Conference. Maui, US.
- 2015. Speaker. Conference. First International Venice Thymus Meeting. Venice, IT.
- 2014. Speaker. Conference. ThymOZ International meeting. Heron Island, AU.
- 2013. Speaker. Conference. Kyoto T Cell Conference. Kyoto, JP.
- 2013. Speaker. Conference. Kyoto T Cell Conference. Kyoto, JP.
- 2012. Speaker. Conference. ThymusUS International meeting. San Juan, PR.
- 2010. Speaker. Conference. ThymOZ International meeting. Heron Island, AU.
- 2009. Speaker. Conference. Kyoto T Cell Conference. Kyoto, JP.
- 2008. Speaker. Conference. ThymUS International meeting. San Juan, PR.
- 2006. Speaker. Conference. ThymOZ International meeting. Heron Island, AU.
- 2005. Speaker. Conference. Kyoto T Cell Conference. Kyoto, JP.
- 2004. Speaker. Conference. European International Thymus Ring. Rolduc, NL.
- 2003. Speaker. Conference. ThymOZ International meeting. Heron Island, AU.
- 2001. Speaker. Conference. ThymUS International meeting. San Juan, PR.
Formal Peers
- 2014. Distinguished Lecturer In Immunology. Invited. Distinguished Lecturer In Immunology, US.
- 2003. Distinguished Lecturer In Immunology. Invited. Distinguished Lecturer In Immunology, US.
Patient Reviews
CV information above last modified April 02, 2025