Meet Farhad Danesh, M.D.
Farhad R. Danesh, M.D.
Department of Emergency Medicine, Division of Internal Medicine
About Dr. Danesh
The primary interest of our research group is to delineate the molecular mechanisms through which diabetic nephropathy progresses, and to identify and characterize novel molecular targets that could potentially prevent progression of diabetic kidney disease. We utilize animal models of diabetes to accomplish these ambitious goals. Along these lines, we aim to examine the novel regulatory factors that lead to the development and/or progression of diabetic nephropathy. We are currently testing two broad objectives. The first is to gain insight into the pathobiology of mitochondria in the kidneys. In particular, we want to understand the biological functions of mitochondrial dynamics and how disrupting the functions of mitochondria contribute to the pathogenesis of diabetic kidney disease. Our group discovered that mitochondrial dynamics is a major molecular mechanism implicated in glucose-mediated microvascular organ damage (Wang W et al. Cell Met. 2012,15:186-200).. This has created a paradigm shift in the field. The second is to understand the regulatory effects of microRNAs in microvascular complications of diabetes. Our laboratory has been on the forefront of identifying multiple miRNAs and their downstream effectors in the kidney. We have recently published novel observations on the potential effects of miRNAs in diabetic nephropathy (Long J. et al: J. Biol. Chem . 2010, 285:23457–23465; and Long J. et al: J. Biol. Chem. 2011, 286: 11837-11848). These collective efforts have significantly accelerated the process of assessing the role of miRNAs in the pathobiology of diabetic nephropathy. Collectively, our research paradigm uses a combined approach of molecular genetics, genomics and epigenomics to understand the underlying pathological and molecular basis of diabetic nephropathy.
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Present Title & Affiliation
Primary Appointment
Professor of Medicine with Tenure, Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX
Chief, Section of Nephrology, Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX
Adjunct Professor of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, Houston, TX
Professor of Medicine with tenure, Department of Internal Medicine, Division of Nephrology, Baylor College of Medicine, Houston, TX, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Professor of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX
Professor of Medicine with tenure, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor of Medicine with tenure, Department of Internal Medicine, Division of Nephrology, Baylor College of Medicine, Houston, TX
Research Interests
1. Rho GTPases
2. Mitochondria
3. microRNAs
4. Long non-coding RNAs
5. Cisplatin-induced nephrotoxicity
6. Diabetic nephropathy
Education & Training
Degree-Granting Education
| 1989 | University of Alcala Medical School, Madrid, ES, MD |
Postgraduate Training
| 1998-1999 | Nephrology Research Fellowship, Laboratory of Daniel Batlle, MD, Northwestern University Medical School, Chicago, Illinois |
| 1996-1998 | Nephrology Clinical Fellowship, Northwestern University Medical School, Chicago, Illinois |
| 1993-1996 | Internship/Residency, University of Chicago / Weiss Memorial Hospital Program, Chicago, Illinois |
| 1991-1992 | Cancer Research Fellowship, Laboratory of Yaacov Ben-David, MD, University of Toronto, Toronto |
Licenses & Certifications
| 2024 | Mississippi State Board of Medical Licensure |
| 2024 | Georgia Composite Medical Board |
| 2024 | Oklahoma State Board of Medical Licensure |
| 2024 | Alabama Board of Medical Examiners |
| 2024 | Tennessee Board of Medical Examiners |
| 2023 | Arizona Board of Medical Examiners |
| 2023 | Washington State Department of Health |
| 2023 | Louisiana State Board of Medical Examiners |
| 2021 | Florida Board of Medicine |
| 2013 | Drug Enforcement Administration |
| 1999 | American Board of Nephrology |
| 1996 | Texas Medical Board |
| 1996 | American Board of Internal Medicine |
| 1993 | Educational Commission for Foreign Medical Graduates |
| 1993 | Illinois Medical License |
Experience & Service
Faculty Academic Appointments
Professor of Pharmacology, Baylor College of Medicine, Houston, TX, 2012 - 2013
Associate Professor of Pharmacology, Baylor College of Medicine, Houston, TX, 2008 - 2012
Associate Professor with tenure, Baylor College of Medicine, Houston, TX, 2007 - 2012
Assistant Professor of Medicine, Northwestern University, Chicago, IL, 2001 - 2007
Instructor of Medicine, Northwestern University, Chicago, IL, 1999 - 2001
Administrative Appointments/Responsibilities
Chief, Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - Present
Director, Inpatient Dialysis, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2017
Extramural Institutional Committee Activities
Member, Infectious Diseases, Infection Control and Employee Health Chair Search Committee, The University of Texas MD Anderson Cancer Center, 2021 - 2022
Member, Promotion and Tenure Committee, The University of Texas MD Anderson Cancer Center, 2021 - 2024
Member, Research Committee, The University of Texas MD Anderson Cancer Center, 2016 - 2018
Chair, Dialysis Steering Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2019
Chair, Distinguished Paper Award Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2018
Member, Internal Medicine Research Committee, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2013 - Present
Standing Member, Pathobiology of Kidney Disease Study Section, Bethesda, MD, National Institutes of Health, 2010 - 2015
Member, NIDDK RFA-DK-08-015. Chronic Kidney Disease Biomarker Discovery, National Institutes of Health, 2009 - Present
Member, American Foundation for Medical Research, American Foundation for Medical Research, 2008 - 2010
Member, NIDDK PBKD Special Emphasis Panel, National Institutes of Health, 2007 - Present
Member, Research Grant Committee, National Kidney Foundation, 2007 - 2014
Member, Committee on Scientific Integrity, Baylor College of Medicine, 2007 - 2012
Standing Member, Merit Review Subcommittee for Nephrology, Department of Veterans Affairs, 2007 - 2012
Member, Member, NIH/NIDDK Renal & Urological Sciences-B Study Section, ZRG1-RUS-B, National Institutes of Health, 2006
Member, Scientific Advisory Committee (SAC), Northwestern University, 2005 - 2007
Member, NIDDK Study Section, RFA-ZDK M1 Animal Models of Diabetic Complications, National Institutes of Health, 2005
Member, NIDDK Study Section, RFA-ZDK GRB-4 Angiogenesis & Diabetic Complications, National Institutes of Health, 2005
Member, Faculty Committee, Northwestern University, 2004 - 2007
Member, Northwestern Medical Faculty Foundation, Northwestern University, 1999 - 2005
Organizing Member, Program Committee, Annual Scientific Meeting of the American Society of Nephrology, American Society of Nephrology
Chair, NIDDK ZDK1 GRB-S Study Section, National Institutes of Health
Co-Chair, NIDDK ZRG1 KUDS-H Special Emphasis Study Section, National Institutes of Health
Editorial Activities
Associate Editor, Journal of American Society of Nephrology, 2026 - Present
Editorial Board, Journal of Biological Chemistry, 2024 - 2029
Editorial Board, Frontiers in Pharmacology, 2022 - Present
Editorial Board, Diabetes, 2020 - 2024
Editorial Board, Journal of American Society of Nephrology, 2015 - 2019
Editorial Board, Kidney International, 2013 - Present
Editorial Board, Physiological Genomics, 2012 - 2022
Honors & Awards
| 2022 | Distinguished Achievement Award, American University of Beirut |
| 2018 | Investigator Award, Chinese Society of Nephrology |
| 2017 | Distinguished Research Award, Korean Society of Nephrology |
| 2016 | Distinguished Investigator, Japanese Society of Nephrology |
| 2001 - 2002 | Merck Medical School Award, Merck & Company |
| 2000 | Northwestern Hospital Intramural Award, Northwestern Hospital |
| 1998 | Bristol-Myers Squibb Research Award, Bristol-Myers Squibb |
| 1996 | Outstanding Teaching Award, Weiss Memorial Hospital |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Electron Transport Chain Remodeling in Diabetic Kidney Disease. Invited. Albany Medical College Department of Regenerative & Cancer Cell Biology Seminar. Albany, NY, US.
- 2024. The Role of Electron Transport Chain Remodeling in Diabetic Kidney Disease. Invited. Augusta University Cellular Biology and Anatomy Seminar Series. Augusta, GA, US.
National Presentations
- 2025. Post-Transcriptional and Post-Translational Processing in Glomerular Diseases. Invited. American Society of Nephrology, Annual Meeting. Houston, TX, US.
- 2024. Mitochondrial Complex I Assembly Factor NDUFAF1 Regulates Tubulointerstitial Fibrosis in Diabetic Kidney Disease via a Tricarboxylic Acid Cycle Metabolite. Invited. American Society of Nephrology, Annual Meeting. San Diego, CA, US.
- 2023. The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease. Invited. American Society of Nephrology, Annual Meeting. Philadelphia, PA, US.
- 2023. NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease. Invited. American Society of Nephrology, Annual Meeting, US.
- 2019. Deletion of Proximal Tubular Cell VEGF Production Promotes Renal Fibrosis: Implications for VEGF-Based Cancer Therapy. Poster. American Society of Nephrology, Annual Meeting. Washington, DC, US.
- 2019. Deletion or Inhibition of ARF6 Improves Albuminuria in Type 2 Diabetic Mice. Poster. American Society of Nephrology, Annual Meeting. Washington, DC, US.
- 2019. CAR-T Cells, Checkpoint Inhibitors and the Kidney. Invited. Nephrology for the Consultant with Annual Nephrology Young Investigators Forum. San Diego, CA, US.
- 2019. Kidney Effects of Newer Anticancer Agents. Invited. Nephrology for the Consultant with Annual Nephrology Young Investigators Forum. San Diego, CA, US.
- 2018. Mice with Drp1-S600 Knockin Mutation Exhibit Reduced Mitochondrial Fission and Attenuation of Diabetic Nephropathy. Invited. American Society of Nephrology, Annual Meeting. San Diego, CA, US.
- 2018. Mitochondial Reprogramming in Diabetic Nephropathy. Conference. Keystone Symposia. Santa Fe, NM, US.
- 2017. TMA and Onconephrology. Invited. Onco-Nephrology Symposium. New York, NY, US.
- 2015. Mitochondrial Regulation in the Glomerulus. Invited. American Society of Nephrology, Annual Meeting. San Diego, CA, US.
- 2015. Renal Consults from the Oncology Floor. Invited. American Society of Nephrology, Annual Meeting. San Diego, CA, US.
- 2012. Complications of Diabetes. Invited. Keystone Symposia, US.
- 2011. ROCK1 Promotes Diabetic Nephropathy by Triggering Mitochondrial Fission Through Serine Phosphorylation of Drp1. Invited. American Society of Nephrology, Annual Meeting. Philadelphia, PA, US.
- 2010. MicroRNA-29c Targets Sprouty1, Promotes Apoptosis and fibrosis, and its Inhibition Prevents Progression of Diabetic Nephropathy. Invited. American Society of Nephrology, Annual Meeting. Denver, CO, US.
- 2010. Targeted deletion of ROCK1 confers renoprotection in diabetic nephropathy. Invited. American Society of Nephrology, Annual Meeting. Denver, CO, US.
- 2010. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor (VEGF) in hyperglycemic conditions. Invited. American Society of Nephrology, Annual Meeting. Denver, CO, US.
- 2009. Micromanaging VEGF by microRNA-93 in Diabetes. Invited. American Society of Nephrology, Annual Meeting. San Diego, CA, US.
- 2008. Deletion of Scavenger Receptor A I/II Ameliorates Tubulointerstitial Fibrosis in UUO Mice with Diet-Induced Hypercholesterolemia. Invited. American Society of Nephrology, Annual Meeting. Philadelphia, PA, US.
- 2008. Synthetic Nanofibers Confer Renoprotection Via Delivery of Cytokines Released from Embryonic Stem Cells. Invited. American Society of Nephrology, Annual Meeting. Philadelphia, PA, US.
- 2008. Role of Rap1b GTPase in Modulation of High Glucose-Induced Renal Mitochondrial Injury. Invited. American Society of Nephrology, Annual Meeting. Philadelphia, PA, US.
International Presentations
- 2019. Role of Mitochondria in Diabetic Nephropathy. Invited. keystone symposia. Whistler, British Columbia, CA.
- 2018. Renal Cell Carcinoma. Conference. KDIGO Onconephrology. Milan, IT.
- 2018. Onconephrology. Invited. 2018 Xiangya Kidney disease Forum. Changsha, CN.
- 2017. Nephrotoxicity from cytotoxic agents. Conference. International Conference OncoNephrology. Naples, IT.
- 2016. Mitochondrial Dysfunction in Diabetic Nephropathy. Invited. University of Tokyo. Tokyo, JP.
- 2013. Diabetic Nephropathy-Signaling. Invited. World Diabetes Congress. Melbourne, AU.
- 2013. MicroRNAs in Diabetic Nephropathy. Invited. World Diabetes Congress. Melbourne, AU.
Formal Peers
- 2016. Mitochondrial Dysfunction in Diabetic Nephropathy. Visiting. Osaka, JP.
- 2016. Renal Grand Rounds. Invited. San Antonio, TX, US.
- 2016. Medicine Grand Rounds. Invited. San Antonio, TX, US.
- 2015. Diabetes, Heart and Kidneys. Visiting. Madrid, ES.
- 2013. World Diabetes Conference. Visiting, AU.
- 2013. Grand Rounds. Invited. Charlottesville, VA, US.
- 2013. The 4th International Symposium on Dynamics of Mitochondria. Visiting, JP.
- 2012. ERA-EDTA Annual Meeting. Visiting. Paris, FR.
- 2012. IBT Grand Rounds. Invited, US.
- 2012. Renal Grand Rounds. Invited, US.
- 2012. Pharmacology and Cell Biology. Invited, US.
- 2012. Nephrology Grand Round. Invited, US.
- 2011. Nephrology Grand Round. Invited, US.
- 2011. MicroRNA Lecture Series. Invited, US.
- 2011. Medicine Grand Rounds. Invited, US.
- 2011. Nephrology Grand Round. Invited, US.
- 2010. Nephrology. Invited, US.
- 2010. Nephrology. Invited, US.
- 2010. Nephrology Grand Round. Invited, US.
- 2009. Diabetes. Invited, US.
- 2009. Pharmacology. Invited, US.
- 2008. Scientific Meeting. Invited, US.
- 2007. Nephrology Grand Rounds. Invited, US.
- 2007. Nephrology Grand Rounds. Invited, US.
- 2006. Nephrology. Invited, US.
- 2006. Pediatric Care. Invited, US.
- 2005. Nephrology. Invited, US.
- 2005. Medicine Grand Rounds. Invited, US.
- 2005. Nephrology Grand Rounds. Invited, US.
- 2005. Diabetes, Heart and Kidneys. Invited, US.
- 2004. Endocrinology Grand Rounds. Invited, US.
- 2004. Dept. of Medicine Research Grand Rounds. Invited, US.
- 2004. Renal Grand Rounds. Invited, US.
- 2002. Nephrology. Invited, US.
- 2001. Endocrinology Grands Rounds. Invited. Chicago, US.
- 2001. Nephrology. Invited, US.
Grant & Contract Support
| Date: | 2025 - 2030 |
| Title: | Regulation of Mitochondrial Respiration in Diabetic Kidney Disease |
| Funding Source: | NIH/NIDDK |
| Role: | PI |
| ID: | RO1DK142664-01 |
| Date: | 2019 - 2024 |
| Title: | Role of ARF6 in the Progression of Diabetic Kidney Disease |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| ID: | 1K08DK119466-01 |
| Date: | 2011 - 2025 |
| Title: | MicroRNAs in diabetic nephropathy |
| Funding Source: | NIH/NIDDK |
| Role: | PI |
| ID: | 1R01DK091310 |
| Date: | 2007 - 2025 |
| Title: | Rho Kinases in diabetic nephropathy |
| Funding Source: | NIH/NIDDK |
| Role: | PI |
| ID: | 5R01DK078900 |
| Date: | 2005 - 2010 |
| Title: | Statins-VEGF induced cytoskeletal remodeling |
| Funding Source: | NIH/NIDDK |
| Role: | PI |
| ID: | R01DK067604-05 |
| Date: | 2004 - 2007 |
| Title: | Mechanisms of action and effects in diabetic nephropathy |
| Funding Source: | American Diabetes Association |
| Role: | PI |
| ID: | 1-03-RA-15 |
| Date: | 2003 - 2008 |
| Title: | Pathobiology of HMG-CoA Reductase Inhibitors in Diabetes |
| Funding Source: | NIH/NIDDK |
| Role: | Co-PI |
| ID: | R01DK028492 |
| Date: | 1991 - 2009 |
| Title: | Glomerular capillary wall-normal and pathologic |
| Funding Source: | NIH/NIDDK |
| Role: | Co-I |
| ID: | R01DK028492 |
Selected Publications
Peer-Reviewed Articles
- Si M, Chen J, Yu R, Lin H, Li F, Jung S, Thomas SS, Danesh FR, Wang Y, Peng H, Hu Z. Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy. Kidney Int 108(4):626-641, 2025. e-Pub 2025. PMID: 40505862.
- Ramasamy C, Neelamegam K, Ramachandran S, Xia H, Kapusta DR, Danesh FR, Pandey KN. Podocyte cell-specific Npr1 is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences. Physiol Genomics 56(10):672-690, 2024. e-Pub 2024. PMID: 39101921.
- Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun 15(1):1965, 2024. e-Pub 2024. PMID: 38438382.
- Danesh FR, Mamlouk O. Immune Checkpoint Inhibitor-Associated Nephrotoxicity. Nephron 148(1):11-15, 2024. e-Pub 2023. PMID: 37257429.
- Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L, Saha PK, Kanwar YS, Chang BH, Danesh FR. The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease. J Biol Chem 299(9):105185, 2023. e-Pub 2023. PMID: 37611830.
- Danesh F, Mise K, Long J, Galvan D, Ye Z, Fan G, Serysheva I, Moore T, Wada J, Schumacker P, Chang B. NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease. Res Sq, 2023. e-Pub 2023. PMID: 37461606.
- Long J, Danesh FR. Promises and challenges of miRNA therapeutics. Am J Physiol Renal Physiol 323(6):F673-F674, 2022. e-Pub 2022. PMID: 36264885.
- Li L, Long J, Mise K, Galvan DL, Overbeek PA, Tan L, Kumar SV, Chan WK, Lorenzi PL, Chang BH, Danesh FR. PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites. Cell Rep 36(6):109510, 2021. e-Pub 2021. PMID: 34380028.
- Li L, Sun L, Danesh FR. The multifaceted contributions of long noncoding RNAs on mitochondrial dysfunction in diabetic nephropathy. Diabet Nephrop 1(1):5-8, 2021. e-Pub 2021. PMID: 34690415.
- Malyszko J, Bamias A, Danesh FR, Debska-Slizien A, Gallieni M, Gertz MA, Kielstein JT, Tesarova P, Wong G, Cheung M, Wheeler DC, Winkelmayer WC, Porta C, Participants C. KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation. Kidney Int 98(6):1407-1418, 2020. e-Pub 2020. PMID: 33276867.
- Long J, Galvan DL, Mise K, Kanwar YS, Li L, Poungavrin N, Overbeek PA, Chang BH, Danesh FR. Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1. J Biol Chem 295(47):15840-15852, 2020. e-Pub 2020. PMID: 32467232.
- Porta C, Bamias A, Danesh FR, Debska-Slizien A, Gallieni M, Gertz MA, Kielstein JT, Tesarova P, Wong G, Cheung M, Wheeler DC, Winkelmayer WC, Malyszko J, Participants C. KDIGO Controversies Conference on onco-nephrology: understanding kidney impairment and solid-organ malignancies, and managing kidney cancer. Kidney Int 98(5):1108-1119, 2020. e-Pub 2020. PMID: 33126977.
- Capasso A, Benigni A, Capitanio U, Danesh FR, Di Marzo V, Gesualdo L, Grandaliano G, Jaimes EA, Malyszko J, Perazella MA, Qian Q, Ronco P, Rosner MH, Trepiccione F, Viggiano D, Zoccali C, Capasso G, Onco-Nephrology Participants ICO. Summary of the International Conference on Onco-Nephrology: an emerging field in medicine. Kidney Int 96(3):555-567, 2019. e-Pub 2019. PMID: 31445584.
- Green NH, Galvan DL, Badal SS, Chang BH, LeBleu VS, Long J, Jonasch E, Danesh FR. MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma. Oncogene 38(34):6211-6225, 2019. e-Pub 2019. PMID: 31289360.
- Sun L, Pan X, Wada J, Haas CS, Wuthrich RP, Danesh FR, Chugh SS, Kanwar YS. Withdrawal: Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy. J Biol Chem 294(26):10382, 2019. e-Pub 2019. PMID: 31253690.
- Lin S, Sahai A, Chugh SS, Pan X, Wallner EI, Danesh FR, Lomasney JW, Kanwar YS. Withdrawal: High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. J Biol Chem 294(26):10381, 2019. e-Pub 2019. PMID: 31253689.
- Galvan DL, Long J, Green N, Chang BH, Lin JS, Schumacker P, Truong LD, Overbeek P, Danesh FR. Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice. J Clin Invest 130(7):2807-2823, 2019. e-Pub 2019. PMID: 31063459.
- Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest 129(3):1129-1151, 2019. e-Pub 2019. PMID: 30741721.
- Long J, Danesh FR. Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy. Diabetes 67(4):552-553, 2018. e-Pub 2018. PMID: 29559513.
- Galvan DL, Badal SS, Long J, Chang BH, Schumacker PT, Overbeek PA, Danesh FR. Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy. Kidney Int 92(5):1282-1287, 2017. e-Pub 2017. PMID: 28754553.
- Galvan DL, Green NH, Danesh FR. The hallmarks of mitochondrial dysfunction in chronic kidney disease. Kidney Int 92(5):1051-1057, 2017. e-Pub 2017. PMID: 28893420.
- Wang W, Badal S, Wang Y, Long J, Wang J, Danesh FR. Real-Time In Vivo Mitochondrial Redox Assessment Confirms Enhanced Mitochondrial ROS in Diabetic Nephropathy. Kidney International 92:1282-1287, 2017. e-Pub 2017.
- Galvan DL, Danesh FR. β2-adrenergic receptors in inflammation and vascular complications of diabetes. Kidney Int 92(1):14-16, 2017. e-Pub 2017. PMID: 28646990.
- Doshi M, Lahoti A, Danesh FR, Batuman V, Sanders PW, Onco-Nephrology Forum ASON. Paraprotein-Related Kidney Disease: Kidney Injury from Paraproteins-What Determines the Site of Injury?. Clin J Am Soc Nephrol 11(12):2288-2294, 2016. e-Pub 2016. PMID: 27526707.
- Long J, Badal SS, Ye Z, Wang Y, Ayanga BA, Galvan DL, Green NH, Chang BH, Overbeek PA, Danesh FR. Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest 126(11):4205-4218, 2016. e-Pub 2016. PMID: 27760051.
- Ayanga BA, Badal SS, Wang Y, Galvan DL, Chang BH, Schumacker PT, Danesh FR. Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy. J Am Soc Nephrol 27(9):2733-47, 2016. e-Pub 2016. PMID: 26825530.
- Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR. miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. Nat Commun 28(7):12076-82, 2016. e-Pub 2016. PMID: 27350436.
- Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation. J Am Soc Nephrol 27(2):509-19, 2016. e-Pub 2016. PMID: 26054539.
- Badal SS, Danesh FR. Diabetic Nephropathy: Emerging Biomarkers for Risk Assessment. Diabetes 64(9):3063-5, 2015. e-Pub 2015. PMID: 26294427.
- Luo J, Liang M, Mitch WE, Danesh FR, Yu M, Cheng J. FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice. Endocrinology 156(6):2200-10, 2015. e-Pub 2015. PMID: 25774552.
- Badal SS, Danesh FR. MicroRNAs and their applications in kidney diseases. Pediatr Nephrol 30(5):727-40, 2015. e-Pub 2015. PMID: 24928414.
- Long J, Badal SS, Wang Y, Chang BH, Rodriguez A, Danesh FR. MicroRNA-22 is a Master Regulator of Bone Morphogenetic Protein-7/6 Homeostasis in the Kidney. J Biol Chem 288(51):36202-14, 2013. e-Pub 2013. PMID: 24163368.
- Wang W, He B, Shi W, Liang X, Ma J, Shan Z, Hu Z, Danesh FR. Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int 81(10):1002-14, 2012. e-Pub 2012. PMID: 22377830.
- Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Chang BH, Schumacker PT, Danesh FR. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 15(2):186-200, 2012. e-Pub 2012. PMID: 22326220.
- Bakota EL, Wang Y, Danesh FR, Hartgerink JD. Injectable multidomain peptide nanofiber hydrogel as a delivery agent for stem cell secretome. Biomacromolecules 12(5):1651-7, 2011. e-Pub 2011. PMID: 21417437.
- Long J, Wang Y, Wang W, Chang BH, Danesh FR. MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem 286(13):11837-48, 2011. e-Pub 2011. PMID: 21310958.
- Wang Y, Bakota E, Chang BH, Entman M, Hartgerink JD, Danesh FR. Peptide nanofibers preconditioned with stem cell secretome are renoprotective. J Am Soc Nephrol 22(4):704-17, 2011. e-Pub 2011. PMID: 21415151.
- Long J, Wang Y, Wang W, Chang BH, Danesh FR. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 285(30):23457-65, 2010. e-Pub 2010. PMID: 20501654.
- Wang J, Wang Y, Long J, Chang BH, Wilson MH, Overbeek P, Danesh FR. Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo. Genesis 48(7):446-51, 2010. e-Pub 2010. PMID: 20641128.
- Sun L, Xie P, Wada J, Kashihara N, Liu FY, Zhao Y, Kumar D, Chugh SS, Danesh FR, Kanwar YS. Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction. J Am Soc Nephrol 19(12):2293-301, 2008. e-Pub 2008. PMID: 18753253.
- Kolavennu V, Zeng L, Peng H, Wang Y, Danesh FR. Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. Diabetes 57(3):714-23, 2008. e-Pub 2008. PMID: 18083785.
- Kanwar YS, Danesh FR, Chugh SS. Chimerism of the renal glomerulus revisited. J Am Soc Nephrol 18(8):2215-7, 2007. e-Pub 2007. PMID: 17625114.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol 291(5):F995-1004, 2006. e-Pub 2006. PMID: 16774905.
- Xu H, Liu P, Liang L, Danesh FR, Yang X, Ye Y, Zhan Z, Yu X, Peng H, Sun L. RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin. Arthritis Rheum 54(11):3441-51, 2006. e-Pub 2006. PMID: 17075836.
- Tramonti G, Xie P, Wallner EI, Danesh FR, Kanwar YS. Expression and functional characteristics of tubular transporters: P-glycoprotein, PEPT1, and PEPT2 in renal mass reduction and diabetes. Am J Physiol Renal Physiol 291(5):F972-80, 2006. e-Pub 2006. PMID: 17028260.
- Nayak B, Xie P, Akagi S, Yang Q, Sun L, Wada J, Thakur A, Danesh FR, Chugh SS, Kanwar YS. Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience. Proc Natl Acad Sci U S A 102(50):17952-7, 2005. e-Pub 2005. PMID: 16330753.
- Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J 19(13):1845-7, 2005. e-Pub 2005. PMID: 16160062.
- Kanwar YS, Akagi S, Nayak B, Sun L, Wada J, Xie P, Thakur A, Chugh SS, Danesh FR. Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development. Kidney Int 68(4):1670-83, 2005. e-Pub 2005. PMID: 16164644.
- Chen S, Lee JS, Iglesias-de la Cruz MC, Wang A, Izquierdo-Lahuerta A, Gandhi NK, Danesh FR, Wolf G, Ziyadeh FN. Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy. Nephrol Dial Transplant 20(7):1320-8, 2005. e-Pub 2005. PMID: 15840669.
- Zeng L, Xu H, Chew TL, Chisholm R, Sadeghi MM, Kanwar YS, Danesh FR. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. J Am Soc Nephrol 15(7):1711-20, 2004. e-Pub 2004. PMID: 15213258.
- Zeng L, Kanwar YS, Amro N, Phillips C, Molitch M, Batlle D, Danesh FR. Epigenetic and genetic analysis of p16 in dermal fibroblasts from type 1 diabetic patients with nephropathy. Kidney Int 63(6):2094-102, 2003. e-Pub 2003. PMID: 12753296.
- Lin S, Sahai A, Chugh SS, Pan X, Wallner EI, Danesh FR, Lomasney JW, Kanwar YS. High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. J Biol Chem 277(44):41725-35, 2002. e-Pub 2002. PMID: 12196513.
- Sun L, Pan X, Wada J, Haas CS, Wuthrich RP, Danesh FR, Chugh SS, Kanwar YS. Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy. J Biol Chem 277(33):29953-62, 2002. e-Pub 2002. PMID: 12171997.
- Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci U S A 99(12):8301-5, 2002. e-Pub 2002. PMID: 12048257.
- Danesh FR, Lynch P, Kanwar YS. Lupus membranous glomerulonephritis mimicking hepatitis C-associated nephropathy. Am J Kidney Dis 39(3):E19, 2002. e-Pub 2002. PMID: 11877599.
- Danesh FR, Ye M, Salmi S, Lapointe M, Batlle D. Temporal profile of serum-induced S-phase entry and retinoblastoma protein phosphorylation in human skin fibroblasts. Kidney Int 56(4):1282-5, 1999. e-Pub 1999. PMID: 10504475.
- Keilani T, Danesh FR, Schlueter WA, Molteni A, Batlle D. A subdepressor low dose of ramipril lowers urinary protein excretion without increasing plasma potassium. Am J Kidney Dis 33(3):450-7, 1999. e-Pub 1999. PMID: 10070908.
- Danesh FR, Batlle D. H+-ATPase in hyperkalemic distal renal tubular acidosis. Am J Kidney Dis 32(6):1091-5; discussion 1095-7, 1998. e-Pub 1998. PMID: 9856531.
Review Articles
- Coellar JD, Long J, Danesh FR. Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy. Nephron:1-11. e-Pub 2021. PMID: 33853077.
- Galvan DL, Mise K, Danesh FR. Mitochondrial Regulation of Diabetic Kidney Disease. Front Med (Lausanne) 8:745279, 2021. e-Pub 2021. PMID: 34646847.
- Mise K, Galvan DL, Danesh FR. Shaping Up Mitochondria in Diabetic Nephropathy. Kidney360 1(9):982-992, 2020. e-Pub 2020. PMID: 34189465.
- Badal SS, Danesh FR. New insights into molecular mechanisms of diabetic kidney disease. Am J Kidney Dis 63(2 Suppl 2):S63-83, 2014. e-Pub 2014. PMID: 24461730.
- Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 233(1):4-11, 2008. e-Pub 2008. PMID: 18156300.
- Kanwar YS, Danesh FR, Chugh SS. Contribution of proteoglycans towards the integrated functions of renal glomerular capillaries: a historical perspective. Am J Pathol 171(1):9-13, 2007. e-Pub 2007. PMID: 17591948.
- Kanwar YS, Nayak B, Lin S, Akagi S, Xie P, Wada J, Chugh SS, Danesh FR. Hyperglycemia: its imminent effects on mammalian nephrogenesis. Pediatr Nephrol 20(7):858-66, 2005. e-Pub 2005. PMID: 15875217.
- Shah S, Paparello J, Danesh FR. Effects of statin therapy on the progression of chronic kidney disease. Adv Chronic Kidney Dis 12(2):187-95, 2005. e-Pub 2005. PMID: 15822054.
- Kanwar YS, Akagi S, Sun L, Nayak B, Xie P, Wada J, Chugh SS, Danesh FR. Cell biology of diabetic kidney disease. Nephron Exp Nephrol 101(3):e100-10, 2005. e-Pub 2005. PMID: 16088221.
- Danesh FR, Kanwar YS. Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. FASEB J 18(7):805-15, 2004. e-Pub 2004. PMID: 15117885.
- Kanwar YS, Wada J, Lin S, Danesh FR, Chugh SS, Yang Q, Banerjee T, Lomasney JW. Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am J Physiol Renal Physiol 286(2):F202-15, 2004. e-Pub 2004. PMID: 14707006.
- Danesh FR, Wada J, Wallner EI, Sahai A, Srivastava SK, Kanwar YS. Gene regulation of aldose-, aldehyde- and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitus. Curr Med Chem 10(15):1399-406, 2003. e-Pub 2003. PMID: 12871137.
- Danesh FR, Anel RL, Zeng L, Lomasney J, Sahai A, Kanwar YS. Immunomodulatory effects of HMG-CoA reductase inhibitors. Arch Immunol Ther Exp (Warsz) 51(3):139-48, 2003. e-Pub 2003. PMID: 12894868.
- Danesh FR, Klinkmann J, Yokoo H, Ivanovich P. Fatal cervical spondyloarthropathy in a hemodialysis patient with systemic deposition of beta2-microglobulin amyloid. Am J Kidney Dis 33(3):563-6, 1999. e-Pub 1999. PMID: 10070922.
Other Articles
- Mise, K, Long, J, Galvan, D, Ye, Z, Fan, G, Sharma, R, Serysheva, I, Moore, T, Jeter, CR, Anna Zal, M, Araki, M, Wada, J, Schumacker, PT, Chang, B, Danesh, FR Correction to. Nature communications 15(1), 2024. PMID: 38589378.
Editorials
- Galvan DL, Danesh FR. Paradoxical Role of IL-17 in Progression of Diabetic Nephropathy. J Am Soc Nephrol 27(3):657-8, 2016. PMID: 26334029.
- Badal SS, Danesh FR. Strategies to reverse endothelial dysfunction in diabetic nephropathy. Kidney Int 82(11):1151-4, 2012. PMID: 23151985.
- Badal SS, Danesh FR. Managing microvascular complications of diabetes with microRNAs. J Am Soc Nephrol 23(2):185-7, 2012. PMID: 22241893.
Abstracts
- Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L, Saha PK, Kanwar YS, Chang BH, Danesh FR. The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease. J Biol Chem 299(9):105185, 2023. e-Pub 2023. PMID: 37611830.
- Long J, Wang Y, Wang W, Danesh FR. MicroRNA-29c targets sprouty1, promotes apoptosis and fibrosis, and its inhibition prevents progression of diabetic nephropathy. Anerican Society of Hephrology Annual Meeting, Oral Presentation, 2010. e-Pub 2010.
- Wang W, Wang Y, Long J, Danesh FR. Targeted deletion of ROCK1 confers renoprotection in diabetic nephropathy. American Society of Nephrology Annual Meeting, Oral Presentation, 2010. e-Pub 2010.
- Long J, Wang Y, Danesh FR. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factr (VEGF) in hyperglycemic conditions. American Society of Nephrology Annual Meeting, Oral Presentation, 2010. e-Pub 2010.
- Long J, Wang Y, Danesh FR. Micromanaging VEGF by microRNA-93 in diabetes. American Society of Nephrology Annual Meeting, Oral Presentation, 2009. e-Pub 2009.
- Wang W, Shi W, Liang S, Yu X, FR D. Deletion of Scavenger Receptor A |/|| Ameliorates Tubulointerstitial Fibrosis in UUO Mice with Diet- Induced Hypercholesterolemia. American Society of Nephrology Annual Meeting, 2008. e-Pub 2008.
- Sun L, Xie P, Liu FU, Chugh SS, Danedh FR. Role of Rap1b GTPase in Modulation of High Glucose-Induced Renal Mitochondrial Injury. American Society of Nephrology Annual Meeting, 2008. e-Pub 2008.
- Wang Y, Zhang G, Wang W, Bakato EL, Crane AM, Hartgerink D, Danesh FR. Synthetic nanofibers confer renoprotection via delivery of cytokines released from embryonic stem cells. American Society of Nephrology, Annual Meeting, 2008. e-Pub 2008.
Book Chapters
- Badal S, Danesh FR. Systems Biology of Free Radicals and Antioxidant. In: Reactive oxygen species and diabetic nephropathy. Spriger-Verlag Berlin Heidelberg, 2014.
- Paparello J, Danesh FR. Pier Module 11. In: Acute Glomerulonephritis. American College of Physicians, 2004.
Patient Reviews
CV information above last modified July 22, 2026