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Fernando Benavides, DVM, PhD, DACLAM

Present Title & Affiliation

Primary Appointment

Associate Professor NTRA, Department of Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Smithville, TX

Dual/Joint/Adjunct Appointment

Adjunct Associate Professor, College of Veterinary Medicine Texas A&M University, College Station, TX
Associate Faculty Member, Graduate School of Biomedical Sciences (GSBS), Houston, TX
Adjunct Graduate Faculty, Texas State University, San Marcos, TX

Research Interests

The overall goal of my research is to define new mouse models through forward genetics. As part of our positional cloning and phenotyping projects, we are studying spontaneous mouse mutations with skin phenotypes, aiming to identify genes important for skin and hair follicle biology. Our ultimate goal is to develop new animal models, particularly but not limited to mouse models of cancer. As the Director of the Animal Genetics Service of the Research Animal Support Facility-Smithville, I advise and coordinate speed congenics projects, genetic monitoring, background characterizations, and whole genome scans for MD Anderson faculty. I also provide free consultation on rodent genetics (including strain selection and standard nomenclature).

Office Address

The University of Texas MD Anderson Cancer Center
1808 Park Rd 1C, PO Box 389
Smithville, TX 78957
Room Number: Office trailer 014
Phone: (512) 237-9343
Email: fbenavid@mdanderson.org

Education & Training

Degree-Granting Education

1998 University of Buenos Aires, School of Veterinary Medicine, Buenos Aires, Argentina, PHD, Genetics
1986 University of Buenos Aires, School of Veterinary Medicine, Buenos Aires, Argentina, DVM, Veterinary Medicine

Board Certifications

7/2003 American College of Laboratory Animal Medicine (ACLAM)

Experience/Service

Administrative Appointments/Responsibilities

Director of Genetic Services, Department of Molecular Carcinogenesis, Research Animal Support Facility, The University of Texas MD Anderson Cancer Center, Smithville, TX, 4/2006-present
Veterinarian/Geneticist, Department of Molecular Carcinogenesis, Research Animal Support Facility, The University of Texas MD Anderson Cancer Center, Smithville, TX, 7/2003-present

Institutional Committee Activities

Member, Institutional Animal Care and Use Committee (IACUC), 9/2006-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Garg R, Blando J, Perez CJ, Wang H, Benavides F, Kazanietz MG. Activation of Nuclear Factor-kappa B in prostate cancer is mediated by Protein Kinase C epsilon. Journal of Biological Chemistry 287(44):37570-82, 10/2012. PMID: 22955280.
2. Perez C, Parker-Thornburg J, Mikulec C, Kusewitt DF, Fischer SM, Digiovanni J, Conti CJ, Benavides F. SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies. Exp Dermatol 21(3):217-220, 3/2012. PMID: 22379968.
3. Ferguson BW, Gao X, Kil H, Lee J, Benavides F, Abba MC, Aldaz CM. Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One 7(5):e36618, 2012. e-Pub 5/4/2012. PMCID: PMC3344920.
4. Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, Digiovanni J, Conti CJ. Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog 51(4). e-Pub 5/2/2011. PMCID: PMC3155742.
5. Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, Kazanietz MG. Transgenic overexpression of PKCe in the mouse prostate induces preneoplastic lesions. Cell Cycle 10(2):268-277, 1/2011. e-Pub 1/2011. PMCID: PMC3048798.
6. Perez CJ, Jaubert J, Guenet J-L, Barnhart KF, Ross-Inta CM, Quintanilla VC, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I, and other hyperammonemic syndromes. American Journal of Pathology 177(4):1958-1968, 2010. PMID: 20724589.
7. Rojas P, Benavides F, Blando J, Perez C, Cardenas K, Richie E, Knudsen ES, Johnson DG, Senderowicz AM, Rodriguez-Puebla ML, Conti CJ. Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b). Molecular Carcinogenesis 48(6):508-16, 6/2009. e-Pub 10/2008. PMID: 18942117.
8. Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, Walker CL. PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. American Journal of Pathology 174(5):1869-79, 5/2009. PMCID: PMC2671275.
9. Benavides F, Oberyszyn TM, Van Buskirk A, Kusewitt DF. The hairless mouse in skin research. Journal of Dermatological Science 53(1):10-8, 1/2009. PMCID: PMC2646590.
10. Rojas P, Cadenas MB, Lin PC, Benavides F, Conti CJ, Rodriguez-Puebla ML. Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis. Oncogene 26(12):1723-30, 2007. PMID: 16983339.
11. Benavides F, Gomez G, Venables-Griffith A, Lambertz I, Flores M, Angel JM, Fuchs-Young R, Richie ER, Conti CJ. Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice. Molecular Carcinogenesis 45(7):543-8, 7/2006. PMID: 16479612.
12. Kim E, Rundhaug JE, Benavides F, Yang P, Newman RA, Fischer SM. An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Oncogene 24(7):1174-87, 2/2005. PMID: 15558016.
13. Benavides F, Conti CJ, LaCava M, Flores M, Glasscock E, Sternik G, Gimenez-Conti IB, Johnston DA, Dunsford HA, Goldstein LS, Rodriguez LV. Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar. Environmental and Molecular Mutagenesis 41(4):300-8, 2003. PMID: 12717785.
14. Benavides F, Zamisch M, Flores M, Campbell MR, Andrew SE, Angel JM, Licchesi J, Sternik G, Richie ER, Conti CJ. Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis. Genes Chromosomes Cancer 35(4):299-310, 12/2002. PMID: 12378524.
15. Benavides F, Starost MF, Flores M, Gimenez-Conti IB, Guenet JL, Conti CJ. Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. American Journal of Pathology 161(2):693-703, 8/2002. PMCID: PMC1850757.

Last updated: 7/15/2013