Fernando Benavides, DVM, PhD, DACLAM
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
About Dr. Benavides
Dr. Benavides is a mouse geneticist (PhD) and laboratory animal veterinarian (DVM, ACLAM) with extensive experience in describing new mouse models derived from both spontaneous mutations and targeted genetic modifications. Dr. Benavides has a strong background in positional cloning of spontaneous mutations and has described several new mouse models. His expertise also includes devising complex breeding schemes, genotyping, and phenotyping mouse models. As the director of the Laboratory Animal Genetics Services at MD Anderson Cancer Center, Dr. Benavides carries out genetic monitoring of inbred strains (and authentication of mouse cell lines) and numerous speed congenic projects aimed to move genes of interest from undefined (mixed) genetic backgrounds to the inbred strain of choice (using genetic markers such as microsatellites and SNPs). Dr. Benavides offers rodent genetic consultation both institution-wide and internationally.
Present Title & Affiliation
Primary Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Smithville
Associate Faculty Member, Graduate School of Biomedical Sciences (GSBS), Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas
Associate Faculty Member, Graduate School of Biomedical Sciences (GSBS), Houston, TX
Research Interests
Dr. Benavides’ research objectives are to define new mouse models through forward genetics. As part of his positional cloning and phenotyping projects, he is studying spontaneous mouse mutations with skin phenotypes, aiming to identify genes important for skin and hair follicle biology. Dr. Benavides’ ultimate goal is to develop new animal models, particularly but not limited to mouse models of cancer. As the Director of the Laboratory Animal Genetics Services of the Research Animal Support Facility-Smithville, Dr. Benavides’ interests are to improve the techniques used to carry out speed congenics projects and background characterizations for genetically engineered mouse models at MD Anderson and outside the institution.
Education & Training
Degree-Granting Education
| 1998 | University of Buenos Aires, School of Veterinary Medicine, Buenos Aires, AR, Genetics, Ph.D |
| 1986 | University of Buenos Aires, School of Veterinary Medicine, Buenos Aires, AR, Veterinary Medicine, DVM |
Postgraduate Training
| 2012-2012 | Continuing Education, Pathobiology of the Mouse Tier 1B (122GNP102), University of California, Davis, California |
| 1998-2002 | Research Fellowship, Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas |
Board Certifications
| 2003 | American College of Laboratory Animal Medicine (ACLAM) |
Experience & Service
Academic Appointments
Associate Professor NTRA, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, 2008 - 2015
Adjunct Associate Professor, College of Veterinary Medicine Texas A&M University, College Station, TX, 2008 - 2015
Adjunct Assistant Professor, Department of Veterinary Pathobiology, College of Veterinary Medicine Texas A&M University, College Station, TX, 2005 - 2008
Assistant Professor NTRA, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, TX, 2003 - 2008
Instructor, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, TX, 2002 - 2003
Research Associate, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, TX, 1999 - 2002
Postdoctoral Fellow, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, TX, 1998 - 1999
Director Animal Care Facility, Department of Experimental Medicine Division, Academia Nacional de Medicina, Buenos Aires, 1989 - 1998
Administrative Appointments/Responsibilities
Director ad interim GEMF core, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - 2023
Director of Transgenic Core, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2017 - 2021
Director of Research Histology Pathology and Imaging Core, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2014 - 2017
Coordinator of Emergency Cryopreservation Program, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, 2011 - 2014
Director of Laboratory Animals Genetic Services, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2006 - Present
Veterinarian/Geneticist RASF-S, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2003 - 2021
Other Appointments/Responsibilities
Member, International Committee on Standardized Genetic Nomenclature for Mice, Bar Harbor JAX, 2022 - 2027
Consultant, Transnetyx, Cordova, TN, 2017 - 2022
Chair of the search committee for a Veterinary Pathologist position, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2015 - 2016
Member of the Nomination and Election Committee, International Mammalian Genome Society, Chapel Hill, NC, 2014 - 2019
Member, FELASA Working Group on Genetic Quality Assurance and Genetic Monitoring of Laboratory Murines, Madrid, 2014 - 2018
Member, National Advisory Committee for Laboratory Animal Research, Montevideo, 2013 - Present
Member, Scientific Council of Universidade Estadual de Campinas (CEMIB/UNICAMP), Campinas, 2010 - Present
Consultant, The University of Texas at Austin, Animal Resources, Austin, TX, 2007 - 2009
Consultant, Electric Power Research Institute (EPRI), Palo Alto, CA, 2000 - 2002
Institutional Committee Activities
Chief IACUC veterinarian Smithville, Institutional Animal Care and Use Committee (IACUC), 2013 - 2021
IACUC Leadership member, Institutional Animal Care and Use Committee (IACUC), 2013 - Present
Member, Animal Research Infrastructure Planning Committee, 2011 - 2021
Chair, Animal Resource Facility Advisory Committee (ARFAC), 2011 - 2021
Veterinarian Member, Institutional Animal Care and Use Committee (IACUC), 2006 - Present
Member, Rodent Colony Management Committee, 2004 - 2021
Honors & Awards
| 2012 | Multi-Year Appointment Award, MD Anderson Cancer Center |
| 2001 | Travel Award, U.S. Department of Energy (DOE) |
| 2000 | Travel Award, U.S. Department of Energy (DOE) |
| 1996 | Travel Award, International Cooperation Grant CONICET/INSERM |
| 1995 | Travel Award, Centre International des Etudiants et Stagiaires |
| 1995 | Travel Award, Asociacion Argentina del Cancer |
| 1992 | Travel Award, International Union Against Cancer |
| 1990 | Travel Award, Universidad Autonoma de Barcelona |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tzetzo, SL, Kramer, ED, Mohammadpour, H, Kim, M, Rosario, SR, Yu, H, Dolan, MR, Oturkar, CC, Morreale, B, Bogner, P, Stablewski, AB, Benavides, FJ, Brackett, CM, Ebos, JM, Das, GM, Opyrchal, M, Nemeth, MJ, Evans, SS, Abrams, SI. Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression. iScience 27(3), 2024. e-Pub 2024. PMID: 38420590.
- Kuang, X, Salinger, AP, Benavides, FJ, Muller, WJ, Dent, SR, Koutelou, E. USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity. PloS one 19(1 January), 2024. e-Pub 2024. PMID: 38236941.
- Beilinson, HA, Sevilleja, A, Spring, J, Benavides, FJ, Beilinson, V, Neokosmidis, N, Golovkina, T. A single dominant locus restricts retrovirus replication in YBR/Ei mice. Journal of Virology 97(8), 2023. e-Pub 2023. PMID: 37578238.
- Fontes F, Rocha S, Sánchez R, Pessina P, Sebastian M, Benavides F, Breijo M. Detection of high antibodies titers against rat leukemia virus in an outbreak of reproductive disorders and lymphomas in Wistar rats. Lab Anim 56(5):236772221085356, 2022. e-Pub 2022. PMID: 35360996.
- Miglioranza Scavuzzi B, van Drongelen V, Kaur B, Fox JC, Liu J, Mesquita-Ferrari RA, Kahlenberg JM, Farkash EA, Benavides F, Miller FW, Sawalha AH, Holoshitz J. The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope. Commun Biol 5(1):751, 2022. e-Pub 2022. PMID: 35902632.
- Ozirmak Lermi N, Gray SB, Bowen CM, Reyes-Uribe L, Dray BK, Deng N, Harris RA, Raveendran M, Benavides F, Hodo CL, Taggart MW, Colbert Maresso K, Sinha KM, Rogers J, Vilar E. Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer. PLoS Genet 18(4):e1010163, 2022. e-Pub 2022. PMID: 35446842.
- Perez CJ, Mecklenburg L, Fernandez A, Cantero M, de Souza TA, Lin K, Dent SYR, Montoliu L, Awgulewitsch A, Benavides F. Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Exp Dermatol 31(3):330-340, 2022. e-Pub 2022. PMID: 34657330.
- Garg R, Cooke M, Benavides F, Abba MC, Cicchini M, Feldser DM, Kazanietz MG. PKCε Is Required for KRAS-Driven Lung Tumorigenesis. Cancer Res 80(23):5166-5173, 2020. e-Pub 2020. PMID: 32994205.
- Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover TL, Chou J, Geha R, Benavides F, Hume RI, Xu H. LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. Proc Natl Acad Sci U S A 117(46):29155-29165, 2020. e-Pub 2020. PMID: 33139539.
- Rao G, Latha K, Ott M, Sabbagh A, Marisetty A, Ling X, Zamler D, Doucette TA, Yang Y, Kong LY, Wei J, Fuller GN, Benavides F, Sonabend AM, Long J, Li S, Curran M, Heimberger AB. Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells. Clin Cancer Res 26(17):4699-4712, 2020. e-Pub 2020. PMID: 32554515.
- Benavides F, Rülicke T, Prins JB, Bussell J, Scavizzi F, Cinelli P, Herault Y, Wedekind D. Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report. Lab Anim 54(2):135-148, 2020. e-Pub 2020. PMID: 31431136.
- Farkas C, Fuentes-Villalobos F, Rebolledo-Jaramillo B, Benavides F, Castro AF, Pincheira R. Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data. BMC Genomics 20(1):131, 2019. e-Pub 2019. PMID: 30755158.
- Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight 3(16), 2018. e-Pub 2018. PMID: 30135305.
- Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. Cox-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene 37(34):4735-4749, 2018. e-Pub 2018. PMID: 29765153.
- Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A 115(11):2806-2811, 2018. e-Pub 2018. PMID: 29490919.
- Dray BK, Raveendran M, Harris RA, Benavides F, Gray SB, Perez CJ, McArthur MJ, Williams LE, Baze WB, Doddapaneni H, Muzny DM, Abee CR, Rogers J. Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques. Genes Cancer 9(3-4):142-152, 2018. e-Pub 2018. PMID: 30108684.
- Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SY, Clapham DE, Benavides F, Geha RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol 140(6):1651-1659.e1, 2018. e-Pub 2017. PMID: 28192143.
- Napoli E, Song G, Liu S, Espejo A, Perez CJ, Benavides F, Giulivi C. Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills. Sci Rep 7(1):12796, 2017. e-Pub 2017. PMID: 29038583.
- Domínguez ER, Orona J, Lin K, Pérez CJ, Benavides F, Kusewitt DF, Johnson DG. The p53 R72P polymorphism does not affect the physiological response to ionizing radiation in a mouse model. Cell Cycle 16(12):1153-1163, 2017. e-Pub 2017. PMID: 28594296.
- Garg R, Blando JM, Perez CJ, Abba MC, Benavides F, Kazanietz MG. Protein kinase c epsilon cooperates with PTEN loss for prostate tumorigenesis through the CXCL13-CXCR5 pathway. Cell Rep 19(2):375-388, 2017. e-Pub 2017. PMID: 28402859.
- Behe P, Foote JR, Levine AP, Platt CD, Chou J, Benavides F, Geha RS, Segal AW. The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils. Front Pharmacol 8(MAY):262, 2017. e-Pub 2017. PMID: 28553230.
- Portis, M, Floyd, AD, Perez, C, Huskey, PS, Weiss, DA, Coghlan, LG, Benavides, FJ. Evaluating the effectiveness of moxidectin treatment in mite-infested mice and development of an in-house PCR assay for detecting Myobia musculi DNA. Scandinavian Journal of Laboratory Animal Science 42(6), 2016. e-Pub 2016.
- Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 gene. J Invest Dermatol 135(12):3133-43, 2015. e-Pub 2015. PMID: 26288350.
- Perez CJ, Dumas A, Vallières L, Guénet JL, Benavides F. Several Classical Mouse Inbred Strains, Including DBA/2, NOD/Lt, FVB/N, and SJL/J, Carry a Putative Loss-of-Function Allele of Gpr84. J Hered 104(4):565-71, 2013. e-Pub 2013. PMID: 23616478.
- Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of Nuclear Factor-kappa B in prostate cancer is mediated by Protein Kinase C epsilon. J Biol Chem 287(44):37570-82, 2012. e-Pub 2012. PMID: 22955280.
- Perez C, Parker-Thornburg J, Mikulec C, Kusewitt DF, Fischer SM, Digiovanni J, Conti CJ, Benavides F. SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies. Exp Dermatol 21(3):217-220, 2012. e-Pub 2012. PMID: 22379968.
- Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, Digiovanni J, Conti CJ. Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog 51(4):352-361, 2012. e-Pub 2011. PMID: 21538579.
- Ferguson BW, Gao X, Kil H, Lee J, Benavides F, Abba MC, Aldaz CM. Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One 7(5):e36618, 2012. e-Pub 2012. PMID: 22574198.
- Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, Kazanietz MG. Transgenic overexpression of PKCe in the mouse prostate induces preneoplastic lesions. Cell Cycle 10(2):268-277, 2011. e-Pub 2011. PMID: 21224724.
- Perez CJ, Jaubert J, Guénet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I, and other hyperammonemic syndromes. Am J Pathol 177(4):1958-1968, 2010. e-Pub 2010. PMID: 20724589.
- Fu J, Jin F, Zhang J, Fong K, Bassi DE, Lopez De Cicco R, Ramaraju D, Braunewell KH, Conti C, Benavides F, Klein-Szanto AJ. VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. PLoS One 5(4):e10196, 2010. e-Pub 2010. PMID: 20419170.
- Rojas P, Benavides F, Blando J, Perez C, Cardenas K, Richie E, Knudsen ES, Johnson DG, Senderowicz AM, Rodriguez-Puebla ML, Conti CJ. Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b). Mol Carcinog 48(6):508-16, 2009. e-Pub 2009. PMID: 18942117.
- Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, Walker CL. PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. American Journal of Pathology 174(5):1869-79, 2009. e-Pub 2009. PMID: 19395652.
- Chen X, Schneider-Broussard R, Hollowell D, McArthur M, Jeter CR, Benavides F, DiGiovanni J, Tang DG. Abnormal differentiation, hyperplasia and embryonic/perinatal lethality in BK5-T/t transgenic mice. Differentiation 77(3):324-34, 2009. e-Pub 2009. PMID: 19272531.
- Maschi F, Ayala M, Benavides F, Carbone C. Development of the BALB/c.Cg-Ctslnkt congenic mouse strain. Journal of Basic and Applied Genetics 19:15-19, 2009. e-Pub 2009.
- de Cicco RL, Bassi DE, Benavides F, Conti CJ, Klein-Szanto AJ. Inhibition of proprotein convertases: Approaches to block squamous carcinoma development and progression. Mol Carcinog 46(8):654-9, 2007. e-Pub 2007. PMID: 17440928.
- Rojas P, Cadenas MB, Lin PC, Benavides F, Conti CJ, Rodriguez-Puebla ML. Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis. Oncogene 26(12):1723-30, 2007. e-Pub 2007. PMID: 16983339.
- Montero Girard G, Vanzulli SI, Cerliani JP, Bottino MC, Bolado J, Vela J, Becu-Villalobos D, Benavides F, Gutkind S, Patel V, Molinolo A, Lanari C. Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res 9(2):R22, 2007. e-Pub 2007. PMID: 17341305.
- Benavides F, Gomez G, Venables-Griffith A, Lambertz I, Flores M, Angel JM, Fuchs-Young R, Richie ER, Conti CJ. Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice. Molecular Carcinogenesis 45(7):543-8, 2006. e-Pub 2006. PMID: 16479612.
- Fabris VT, Benavides F, Conti C, Merani S, Lanari C. Cytogenetic findings, Trp53 mutations, and hormone responsiveness in a medroxyprogesterone acetate induced murine breast cancer model. Cancer Genet Cytogenet 161(2):130-9, 2005. e-Pub 2005. PMID: 16102583.
- Kim E, Rundhaug JE, Benavides F, Yang P, Newman RA, Fischer SM. An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Oncogene 24(7):1174-87, 2005. e-Pub 2005. PMID: 15558016.
- Bourgade F, Montagutelli X, Bigbee C, Weiss A, Rigottier-Gois L, Conti CJ, Benavides F. Simple duplex fecal PCR assay that allows identification of false-negative results in Helicobacter sp.-infected mice. Comp Med 54(5):528-32, 2004. e-Pub 2004. PMID: 15575366.
- Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 10(12 Pt 1):4029-37, 2004. e-Pub 2004. PMID: 15217935.
- Lopes EC, Garcia M, Benavides F, Shen J, Conti CJ, Alvarez E, Hajos SE. Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype. Leuk Res 27(5):413-23, 2003. e-Pub 2003. PMID: 12620293.
- Benavides F, Conti CJ, LaCava M, Flores M, Glasscock E, Sternik G, Gimenez-Conti IB, Johnston DA, Dunsford HA, Goldstein LS, Rodriguez LV. Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar. Environmental and Molecular Mutagenesis 41(4):300-8, 2003. e-Pub 2003. PMID: 12717785.
- Benavides F, Zamisch M, Flores M, Campbell MR, Andrew SE, Angel JM, Licchesi J, Sternik G, Richie ER, Conti CJ. Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis. Genes Chromosomes Cancer 35(4):299-310, 2002. e-Pub 2002. PMID: 12378524.
- Stern MC, Benavides F, LaCava M, Conti CJ. Genetic analyses of mouse skin tumor progression susceptibility using SENCAR inbred derived strains. Mol Carcinog 35(1):13-20, 2002. e-Pub 2002. PMID: 12203363.
- Benavides F, Starost MF, Flores M, Gimenez-Conti IB, Guénet JL, Conti CJ. Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol 161(2):693-703, 2002. e-Pub 2002. PMID: 12163394.
- Vanzulli S, Efeyan A, Benavides F, Helguero LA, Peters G, Shen J, Conti CJ, Lanari C, Molinolo A. p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis 23(5):749-58, 2002. e-Pub 2002. PMID: 12016147.
- Starost MF, Benavides F, Conti CJ. A variant of pulmonary alveolar microlithiasis in nackt mice. Vet Pathol 39(3):390-2, 2002. e-Pub 2002. PMID: 12014504.
- Benavides F, Glasscock E, Coghlan LG, Stern MC, Weiss DA, Conti CJ. PCR-based microsatellite analysis for differentiation and genetic monitoring of nine inbred SENCAR mouse strains. Lab Anim 35(2):157-62, 2001. e-Pub 2001. PMID: 11315165.
- Benavides F, Venables A, Poetschke Klug H, Glasscock E, Rudensky A, Gomez M, Martin Palenzuela N, Guenet JL, Richie ER, Conti CJ. The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene. Immunogenetics 53(3):233-42, 2001. e-Pub 2001. PMID: 11398968.
- Benavides F, Stern MC, Glasscock E, DiGiovanni J, Coghlan LG, Conti CJ. Microsatellite DNA variants between the inbred SENCAR mouse strains. Mol Carcinog 28(4):191-5, 2000. e-Pub 2000. PMID: 10972988.
- Stern MC, Benavides F, Klingelberger EA, Conti CJ. Allelotype analysis of chemically induced squamous cell carcinomas in F(1) hybrids of two inbred mouse strains with different susceptibility to tumor progression. Carcinogenesis 21(7):1297-301, 2000. e-Pub 2000. PMID: 10874006.
- Benavides F, Salaverry M, Cazalla D, Pereira P, Pazos P, Fontanals A, Corley E. Six cases of paternity disputes resolved by DNA fingerprinting. Revista de Medicina Veterinaria 77(6):397-400, 2000. e-Pub 2000.
- Benavides F, Giordano M, Fiette L, Bueno Brunialti AL, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guenet J. Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics 49(5):413-9, 1999. e-Pub 1999. PMID: 10199917.
- Benavides FJ. Genetic contamination of an SJL/J mouse colony: Rapid detection by PCR-based microsatellite analysis. Contemp Top Lab Anim Sci 38(2):54-55, 1999. e-Pub 1999. PMID: 12086434.
- Gorla N, Benavides F, Salaverry M, Ludueña R, Grandoli N, Corley E, Larripa I. Application of DNA fingerprinting to determine paternity in cattle with large congenital abdominal wall defect progeny (Spanish). Archivos de Medicina Veterinaria 30(2):151-5, 1998. e-Pub 1998.
- Benavides F, Cazalla D, Pereira C, Fontanals A, Salaverri M, Goldman A, Buggiano V, Dran G, Corley E. Evidence of genetic heterogeneity in a BALB/c mouse colony as determined by DNA fingerprinting. Lab Anim 32(1):80-5, 1998. e-Pub 1998. PMID: 9481698.
- Dyzenchauz F, Fontanals A, Benavides F. Experimental animals in Argentina: species and strains (Spanish). Animales de Experimentacion 3(3):23-6, 1998. e-Pub 1998.
- Benavides F, Guenet JL. Gene mapping in mice. Medicina (B Aires) 57(4):507-10, 1997. e-Pub 1997. PMID: 9674277.
- Barassi N, Benavides F, Ceccarelli A. Ethics in the use of experimental animals. Medicina (B Aires) 56(5 Pt 1):531-2, 1996. e-Pub 1996. PMID: 9239891.
- Benavides F. Mutant mice in experimental oncoimmunology. Medicina (B Aires) 55(1):84-7, 1995. e-Pub 1995. PMID: 7565043.
- Bonfil RD, Vinyals A, Bustuoabad OD, Llorens A, Benavides FJ, Gonzáles-Garrigues M, Fabra A. Stimulation of angiogenesis as an explanation of Matrigel-enhanced tumorigenicity. Int J Cancer 58(2):233-9, 1994. e-Pub 1994. PMID: 7517919.
- Benavides F, Pereira C. Evaluation of the genetic quality of mice used in biomedical research. Rev Argent Microbiol 25(2):100-9, 1993. e-Pub 1993. PMID: 8234731.
- Benavides F, Pereira C. Transgenic animals in biomedicine. Medicina (B Aires) 53(4):374-6, 1993. e-Pub 1993. PMID: 8201922.
Invited Articles
- Parker-Thornburg J, Benavides F, Shawlot W, McBeath E. TT2022 meeting report on the 17th Transgenic Technology meeting in Helsinki, Finland. Transgenic Res 31(6):677-681, 2022. e-Pub 2022. PMID: 36441390.
- Benavides F. The sub-world of sub-strains (Spanish). Animales de Laboratorio 76:26-33, 2018. e-Pub 2018.
- Benavides F. The mouse as the star of experimental cancer research (Spanish). National Academy of Medicine of Buenos Aires XI, 2015. e-Pub 2015.
- Benavides F, J-L G. Genetics of mouse pigmentation: the basics (Review in French). Science and Technology of Laboratory Animals (France) 36(4):27-37, 2010. e-Pub 2010.
- Benavides F, Guenet JL. The importance of genetic standardization in laboratory rodents (Review in Spanish). Animales de Laboratorio (Spain) 42:22-30, 2009. e-Pub 2009.
- Benavides F, J-L G. Genetic background and the expression of genes and transgenes: a serious problem (Review in French). Science and Technology of Laboratory Animals (France) 35:45-53, 2009. e-Pub 2009.
- Benavides F, Guenet JL. Systematics of the laboratory mouse (Review in Spanish). Animales de Laboratorio (Spain) 6:7-13, 2000. e-Pub 2000.
Manuals, Teaching Aids, Other Teaching Publications
- Benavides F, J-L G. Genetics of laboratory animals. CIEMAT, 2021.
Other Articles
- Teboul, L, Amos-Landgraf, JM, Benavides, FJ, Birling, MC, Brown, SD, Bryda, EC, Bunton-Stasyshyn, RK, Chin, HG, Crispo, M, Delerue, F, Dobbie, M, Franklin, CL, Fuchtbauer, EM, Gao, X, Golzio, C, Haffner, R, Hérault, Y, De Angelis, MH, Lloyd, KC, Magnuson, T, Montoliu, L, Murray, SA, Nam, KH, Nutter, LM, Pailhoux, E, Pardo Manuel de Villena, F, Peterson, KA, Reinholdt, L, Sedlacek, R, Seong, JK, Shiroishi, T, Smith, C, Takeo, T, Tinsley, L, Vilotte, JL, Warming, S, Wells, S, Whitelaw, CB, Yoshiki, A, Pavlovic, G Improving laboratory animal genetic reporting. NatCom 15(1), 2024. PMID: 38956430.
- Benavides F, Oberyszyn TM, VanBuskirk AM, Reeve VE, Kusewitt DF The hairless mouse in skin research. J Dermatol Sci 53(1):10-8, 2009. PMID: 18938063.
- Benavides F Dominant white spotting mutation on a DBA/2 mouse, a new allele at the Kit locus (on-line article in Spanish). Bioterios.com, 2007.
- Gonzalez-Guerrico AM, Meshki J, Xiao L, Benavides F, Conti CJ, Kazanietz MG Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. J Biochem Mol Biol 38(6):639-645, 2005. PMID: 16336777.
- Benavides F, Guenet JL Murine models for human diseases. Medicina (B Aires) 61(2):215-31, 2001. PMID: 11374148.
Abstracts
- Ozirmak N, Gray S, Raveendran M, Dray B, Harris R, Benavides F, Abee C, Rogers J, Vilar E. Comparative Molecular Genomic Analyses of a Rhesus Lynch Syndrome Model. 2019 Symposia on Cancer Research, 2019. e-Pub 2019.
- Benavides F, Jaubert J, Guenet J. The value of spontaneous mouse mutations as a source of new animal models. XIII FELASA, Brussels, Belgium, 2016. e-Pub 2016.
- Platt C, Chou J, Kumar L, Bainter W, Houlihan P, Clapham DE, Benavides F, Geha RS. A pathogenic hypomorphic mutation in Lrrc8a impairs volume regulated anion channel activity but spares T cell development and function. Clinical Immunology Society, Boston, MA, 2016. e-Pub 2016.
- Perez CJ, Kusewitt DF, Benavides F. n vivo quantification of skin inflammation in Zdhhc13 deficient mice. Innovations in Cancer Prevention and Research Conference, Austin, TX, 2015. e-Pub 2015.
- Bazaga D, Perez CJ, Angel JM, Benavides F. 16.Characterization and mapping of colimba, a new spontaneous mouse mutation with hair coat abnormalities. XXIX International Mouse Genome Conference, Yokohama, Japan, 2015. e-Pub 2015.
- Trotz I, Bussel J, Benavides F, Cinelli P, Herault Y, Rülicke T, Scavizzi F, Prins JB, Wedekind D. Differentiation of genetically modified mice on supposedly C57BL/6 background. 52nd Annual Meeting of the Society for Laboratory Animal Science GV-SOLAS, Frankfurt, Germany, 2014. e-Pub 2014.
- Murphy C, Kumar L, Perez CJ, Jaubert J, J-L G, Geha R, Benavides F. The spontaneous mouse mutation ébouriffé (ebo), associated with infertility and wavy hair, is a nonsense allele of the Lrrc8a (Swell) gene. XXVIII International Mouse Genome Conference, ME, 2014. e-Pub 2014.
- Zurita E, Cantero M, Vicente J, Fernández J, Benavides F, Benítez J, de la Villa P, Montoliu L. Retinal abnormalities found in common albino outbred mice. Transgenic Technology TT2014 Meeting, Edinburgh, Scotland, UK, 2014. e-Pub 2014.
- Santos M, Martínez-Palma L, Benavides F, Moure T, Casal V, Ures X, Rocha S, Breijo M. Development and characterization of a Sprague Dawley rat colony carrying a spontaneous mutation affecting myelination. XV Meeting of the Uruguayan Biosciences Society. Piriapolis, Uruguay, 2014. e-Pub 2014.
- Garg R, Benavides F, Abba M, Blando J, Kazanietz M. CXCL13 as a mediator of oncogenic PKCε in prostate cancer. 105th Annual Meeting of the American Association for Cancer Research, San Diego, CA, 2014. e-Pub 2014.
- Freeman K, Benavides F, Perez C, Schuetz J, Garcia D. Proteomic Comparison Between Mrp4 Knockout and Wild Type Mouse Brain, Liver, Kidney and Serum. World Biotechnology Congress 2013, Boston, MA, 2013. e-Pub 2013.
- Garg R, Lal P, Blando J, Benavides F, Feldman M, Smyth E, Kazanietz M. COX-2 as a mediator of oncogenic PKCε in prostate cancer. Annual Meeting of the American Association for Cancer Research, Washington, DC, 2013. e-Pub 2013.
- Benavides F. The impact of genetic background in mouse and rat models: concerns and solutions. Transgenic Research 22:211, 2013. e-Pub 2013.
- Benavides F, Perez CJ, J-L G. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL, carry a putative loss-of-function allele of Gpr84. XXV International Mouse Genome Conference. St Petersburg, FL, 2012. e-Pub 2012.
- Perez CJ, Benavides F. Some classical mouse inbred strains, including DBA/2, NOD/Lt, and FVB/N, carry a 2-bp deletion in the Gpr84 gene, resulting in a premature stop codon. 39th Annual Meeting of the Texas Genetics Society, San Antonio, TX, 2012. e-Pub 2012.
- Benavides F, Jaubert J, Perez CJ, J-L G, Barrera J, Cole B, Conti CJ. High-resolution map and candidate gene analysis for ébouriffé (ebo), a hair mutation on mouse chromosome 2 associated with infertility. XXIV International Mouse Genome Conference, Crete, Greece, 2010. e-Pub 2010.
- Benavides F, Jaubert J, Perez CJ, Quintanilla VC, Aubin I, Barnhart KF, Gimenez-Conti IB, J-L G, Kusewitt D, Conti CJ. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I, an inherited urea cycle disorder. XXIII International Mouse Genome Conference, La Jolla, CA, 2009. e-Pub 2009.
- Benavides F, Jaubert J, Perez CJ, Quintanilla VC, Aubin I, Barnhart KF, Gimenez-Conti IB, J-L G, Kusewitt D, Conti CJ. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I, an inherited urea cycle disorder. 60th AALAS National Meeting, Denver, CO, 2009. e-Pub 2009.
- Portis MJ, Buckley D, Benavides F, Coghlan LG. Cuterebra sp. infestation of a wild mouse (Peromyscus sp.). Texas Branch AALAS Annual Meeting, San Antonio, TX, 2009. e-Pub 2009.
- Benavides F, Jaubert J, Perez CJ, Quintanilla C, Aubin I, Barnhart K, Gimenez-Conti I, J-L G, Kusewitt D, Conti CJ. The barthez mouse mutation is a hypomorphic allele of the Ass1 gene. XXII Int Mouse Genome Conf, Prague, Czech Republic, 2008. e-Pub 2008.
- Perez CJ, Jaubert J, Aubin I, DiGiovanni J, J-L G, Conti C, Benavides F. A nonsense mutation in the mouse Zdhhc13 gene is responsible for the luca phenotype. XXII Int Mouse Genome Conf, Prague, Czech Republic, 2008. e-Pub 2008.
- Perez CJ, Blando J, Contreras O, DiGiovanni J, Conti CJ, Benavides F. A nonsense mutation in the mouse Zdhhc13 gene is responsible for the luca phenotype. 35th Annual Meeting of the Texas Genetics Society, 2008. e-Pub 2008.
- Perez CJ, Brandon J, Quintanilla VC, Abbey N, Barnhart KF, Gimenez-Conti IB, Conti CJ, Benavides F. The barthezmouse mutation is a hypomorphic allele of the Ass1 gene. 35th Annual Meeting of the Texas Genetics Society, 2008. e-Pub 2008.
- Benavides F, Brandon JL, Quintanilla VC, Perez CJ, Barnahart KF, Aubin I, Jaubert J, J-L G, Gimenez-Conti IB, Conti CJ. Characterization and mappping of barthez, a new mouse mutation with a complex phenotype that includes alopecia. XXI Int Mouse Genome Conf, Kyoto, Japan, 2007. e-Pub 2007.
- Rojas J, Benavides F, Rodriguez-Puebla ML, Blando J, Perez C, Kknudsen ES, Johnson DG, Senderowicz AM, Conti CJ. Enhanced skin carcinogenesis in transgenic mice expressing the human cyclin D1b (CCND1b) variant. 98th Annual Meeting of the AACR, Los Angeles, CA, 2007. e-Pub 2007.
- Blando J, Portis M, Benavides F, Kim J, Mills G, Conti C. PTEN deficiency is fully penetrant for invasive prostatic carcinoma in C57BL/6 mice. Keystone Symposia: PI-3 Kinase Signaling Pathways in Disease, 2007. e-Pub 2007.
- Perez CJ, Mecklenburg L, Mirabzadeh, Aubin I, Iritani BM, Habib T, Park H, Bblando J, Contreras O, J-L G, DiGiovanni J, Conti CJ, Benavides F. Characterization and high resolution mapping of luca, a new mouse hair loss mutation. XX Int Mouse Genome Conf, Charleston SC, 2006. e-Pub 2006.
- Benavides F, Perez CJ, Blando J, Contreras O, DiGiovanni J, Conti CJ. Paradoxical protective role in cathepsin L in mouse skin carcinogenesis. VII Int Skin Carcinogenesis Conf, Austin, TX, 2006. e-Pub 2006.
- Rojas P, Rodriguez-Puebla M, Knudsen E, Benavides F, Johnson D, Senderowicz A, Conti CJ. Development and characterization of a novel transgenic mouse model for a polymorphism of cyclin D1. Third Annual Symposium of the Comparative Mouse Genomics Centers Consortium, Austin, TX, 2004. e-Pub 2004.
- Benavides F, Bigbee C, Weiss A, Lee M, Bourgade F, Montagutelli X, Conti CJ. Duplex fecal PCR assay for the identification of false negative results in mice infected with helicobacter sp. Texas Branch American Assoc of Laboratory Animal Science Annual Meeting, 2004. e-Pub 2004.
- Helguero LA, Lamb CA, Benavides F, Conti CJ, Vanzulli S, Molinolo A, Lanari C. Progresterone receptors as key players in hormone responsive and unresponsive exxperimental mammary carcinomas. Gordon Res Conf on Mammary Gland Biology, Bristol, RI, 2003. e-Pub 2003.
- Christensen LA, Kirby A, Benavides F, Fisicher SM, Conti CJ, Vasquez KM. Mutation frequencies in murine keratinocytes as a function of carcinogenic status. Center for Research on Environmental Disease Symposium: Experimental Models of Human Disease, Austin, TX, 2003. e-Pub 2003.
- Benavides F, Starost M, Flores M, Gimenez-Conti I, J-L G, Conti CJ. Impaiared hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice,m a cathepsin L deficient mutation. XVI Int Mouse Genome Conf, San Antonio, TX, 2002. e-Pub 2002.
- Benavides F, Starost M, Flores M, Gimenez-Conti K, J-L G, Conti CJ. Nackt: A mouse mutation with CD4 T-cell deficiency and impaired epidermal differentiation. American Association for Laboratory Animal Science Annual Meeting, San Antonio, TX, 2002. e-Pub 2002.
- Lopes EC, Garcia M, Benavides F, Shen J, Alvarez, Hajos S. Modulators of multidrug resistance PSC 833 and CsA show differential capacity to induce apoptosis in mouse leukemia cell lines, independently of its MDR phenotype. 38th Annual Meeting of the American Society of Clinical Oncology, Orlando FL, 2002. e-Pub 2002.
- Sternik G, Stern MC, Benavides F, Conti CJ. Analysis of sequential genetic alterations from microdissected archival acetone-fixed and paraffin embedded tumor tissue in mouse skin carcinogenesis. 93rd Annual Meeting of the AACR, San Francisco, CA, 2002. e-Pub 2002.
- Benavides F, Zamisch M, Flores M, Escandon J, Sternik G, Richie E, Conti CJ. Use of inter-simple sequence repeat PCR analysis in mouse carcinogenesis studies. XV Inter Mouse Genome Conf, Edinburgh, Scotland, 2001. e-Pub 2001.
- Vanqulli S, Efeyan A, Lanari C, Benavides F, Shen J, Conti CJ, Molinolo A. p21 requirement for antiprogestin induced regression but not for estrogen induced regression in murine mammary carcinomas expressing ER and PR. Gordon Research Conf on Hormonal Carcinogenesis, Meriden, NH, 2001. e-Pub 2001.
- Benavides F, Zamisch M, Sternik G, Richie E, Conti CJ. Genomic instability in mouse tumors by inter-simple sequence repeat PCR analysis. 92nd Annual Meeting of the AACR, New Orleans, LA, 2001. e-Pub 2001.
Book Chapters
- Benavides F. Genetically defined strains of laboratory rodents and genetic quality controls. In: Science and Technology of Laboratory Animals. SECAL - Laboratory Animals Ltd, 2022.
- Coghlan L, Benavides F. Animal Models of Human Cancer. In: Handbook of Laboratory Animal Science. 4th Edition. CRC Press: United States, 2021.
- Benavides F, J-L G. Rodent Genetics. In: Experimental Design and Reproducibility in Preclinical Animal Studies. Springer Nature, 2021.
- Benavides F. The mouse as the star of experimental cancer research. In: 50th Anniversary of Instituto de Investigaciones Hematológicas Mariano R. Castex, 1956-2006. National Academy of Medicine of Buenos Aires Press, 2015.
- Benavides F, Guenet JL. Mouse Genomics. In: The Laboratory Mouse. Second Edition. Elsevier-Academic Press, 2012.
- Guénet JL, Benavides FJ. Mouse Strains and Genetic Nomenclature. In: Curr Protoc Mouse Biol. First Edition. Wiley-Blackwell, 213-38, 2011.
- Guénet, JL, Benavides, FJ. Genetic Monitoring of Laboratory Rodents, 461-469, 2009.
- Benavides F, Guenet JL. Genetically defined strains of laboratory rodents. In: Science and Technology of Laboratory Animals. Second Edition. SECAL, 2009.
- Guenet JL, Benavides F. Quality control in laboratory rodents. In: Molecular Diagnostics. Second Edition. Elsevier, 2009.
- Guenet JL, Benavides F. Quality control in laboratory rodents. In: Molecular Diagnostics. First Edition. Elsevier, 2005.
Books (edited and written)
- Benavides F, Kornerup A. Rodent Quality Control: Genes and Bugs. Springer Nature, 2024.
- Guenet JL, Benavides F, Montagutelli X, Pantier JJ. Genetics of the Mouse. Springer Verlag, 2015.
- Conti, C, Benavides F, Gimenez-Conti I, (Eds) FA. Atlas of Laboratory Mouse Histology (CD ROM), 2005.
- Benavides F, Guenet JL. Manual of Laboratory Rodents Genetics (Spanish). SECAL and Universidad de Alcala, 2003.
Letters to the Editor
- Benavides F, Perez C, Blando J, Guenet JL, Conti CJ. The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene. J Immunol 176: 702-3, 2006.
Selected Presentations & Talks
Local Presentations
- 2005. The Importance of Genetic Integrity and Background in Mouse Models of Cancer. Conference. The Importance of Genetic Integrity and Background in Mouse Models of Cancer. Houston, TX, US.
Regional Presentations
- 2011. Motivational and scientific presentation for Health Science students from La Joya High School (field experience). Conference. Motivational and scientific presentation for Health Science students from La Joya High School (field experience). Smithville, TX, US.
- 2005. Junior Career Day. Conference. Junior Career Day. Austin, TX, US.
- 2004. Professional Career Day. Conference. Professional Career Day. Austin, TX, US.
- 2003. Professional Career Day. Conference. Professional Career Day. Austin, TX, US.
- 2002. Professional perspectives. Conference. Professional perspectives. Austin, TX, US.
National Presentations
- 2023. Substrains of mice. Conference. Transgenic Technology TT2023 Meeting. Houston, TX, US.
- 2014. The Importance of Genetic Background in Mouse and Rat Models. Conference. Virtual Laboratory Animal Science (LAS) BioConference Live. On-line World wide, US.
- 2010. Mouse Models of Cancer and The Importance of Genetic Background in Mouse and Rat Models. Conference. 61th AALAS National Meeting. Atlanta, GA, US.
- 2009. Mouse Models of Cancer. Conference. 60th AALAS National Meeting. Denver, CO, US.
- 2008. The Importance of Genetic Background in Mouse and Rat Models. Conference. Advances in Transgenic Animal Research. Houston, TX, US.
- 2004. Duplex Fecal PCR Assay for the Identification of False Negative Results in Mice Infected with Helicobacter sp. Conference. TBAALAS Annual Meeting. San Antonio, TX, US.
- 2002. Genetic monitoring of inbred mice and rats. Conference. 53rd AALAS National Meeting (Meeting of the Americas). San Antonio, TX, US.
International Presentations
- 2022. Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Conference. 35th International Mouse Genome Conference. Vancouver, CA.
- 2022. “The Importance of Genetic Background in Mouse and Rat Models and The role of the veterinarian in the IACUC. Conference. 15th FELASA Meeting. Marseille, FR.
- 2018. Deficient LRRC8A-dependent Volume-Regulated Anion Channel (VRAC) activity is associated with male infertility in mice. Conference. 32nd International Mouse Genome Conference. San Juan, PR.
- 2018. The Importance of Genetic Background in Mouse Models of Cancer. Conference. International Skin Carcinogenesis Conference. Austin, US.
- 2018. The Importance of Genetic Background in Mouse Models of Cancer. Conference. University of Sao Paulo. Sao Paulo, BR.
- 2017. Genetics of Laboratory Rodents. Conference. International Congress on Experimental Animal Science and Technology. Guatemala City, GT.
- 2017. Inbred mice, identical but different: the devil is in the details. Conference. Mexican Association of Laboratory Animals (AMCAL). Queretaro, MX.
- 2017. Genetic Background and New Genetic Tools. Conference. XIV Meeting of the Spanish Society of Laboratory Animal Science (SECAL). Palma de Gran Canaria, ES.
- 2016. The Laboratory Mouse in Biomedical Research: Past, Present, and Future. Conference. XIV National Congress SBCAL. Porto Alegre, BR.
- 2015. The Laboratory Mouse in Biomedical Research: Past, Present, and Future. Conference. II Workshop in Laboratory Animals. Buenos Aires, AR.
- 2015. The Importance of Genetic Background in Mouse and Rat Models. Conference. Experimental Biology and Medicine Institute. Buenos Aires, AR.
- 2015. The Importance of Genetic Background in Mouse Models of Cancer. Conference. Experimental Oncology Workshop by Argentine Society of Clinical Research. Buenos Aires, AR.
- 2014. Introduction to Mouse Genetics and The Importance of Genetic Background in Mouse and Rat Models. Conference. XIII National Congress SBCAL. Porto Alegre, BR.
- 2013. Use of genetically modified rodents. Conference. Workshop on Animals bred, but not used in experiments. Amsterdam, NL.
- 2013. The Laboratory Mouse in Biomedical Research: Past, Present, and Future. Conference. IX National Congress of the Mexican Association of Laboratory Animals. Merida, MX.
- 2013. The Impact of Genetic Background in Mouse and Rat Models: Concerns and Solutions. Conference. 11th Transgenic Technology TT2013 Meeting. Guangzhou, CN.
- 2012. The Importance of Genetic Background in Mouse and Rat Models. Conference. Centro de Investigacion y Desarrollo en Ciencias de la Salud. Monterrey, MX.
- 2012. The Laboratory Mouse in Biomedical Research: Past, Present, and Future. Conference. International Symposium on Models in Biomedical Research. Concepcion, CL.
- 2012. Mouse Models of Cancer and Mouse Spontaneous Mutations as New Animal Models. Conference. International Scientific Meeting for the Optimization of Murine Models in Research. Valdivia, CL.
- 2012. The Importance of Genetic Background in Mouse and Rat Models. Conference. AACyTAL workshop. Buenos Aires, AR.
- 2011. The Importance of Genetic Background in Mouse and Rat Models. Conference. II National AACyTAL meeting/IV regional scientific meeting. Mar del Plata, AR.
- 2011. The Importance of Genetic Background in Mouse and Rat Models. Conference. 8th World Congress on Alternatives and Animal Use in the Life Sciences. Montreal, CA.
- 2011. The Challenge of Working with Genetically Modified Rodents. Conference. The International Brain Research Organization World Congress. Florence, IT.
- 2011. Mouse Spontaneous Mutations as New Animal Models. Conference. VIII National Congress of the Mexican Association of Laboratory Animals. Veracruz, MX.
- 2010. The Importance of Genetic Background in Mouse and Rat Models. Conference. Symposium on Animal Models and Cryopreservation at CEMIB. Campinas, BR.
- 2010. Importance of Genetic Background in Mouse and Rat Models. Conference. 11th FELASA and 40th Scand-LAS joint meeting. Helsinki, FI.
- 2009. Mouse Models of Cancer and Genetic Monitoring. Conference. VII National Congress of the Mexican Association of Laboratory Animals. Zacatecas, MX.
- 2009. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I, an inherited urea cycle disorder. Conference. XXIII International Mouse Genome Conference. La Jolla, US.
- 2008. The barthez mouse mutation is a hypomorphic allele of the Ass1 gene. Conference. XXII International Mouse Genome Conference. Prague, CZ.
- 2007. Rodent Genetics. Conference. VI National Congress of the Mexican Association of Laboratory Animals. Manzanillo, MX.
- 2005. Mouse Models of Cancer. Conference. 2nd International Congress on the Future of Animal Research. Rio de Janeiro, BR.
- 2003. Genetic monitoring of inbred mice and rats. Conference. VII Meeting of the Spanish Society of Laboratory Animal Science (SECAL). San Sebastian, ES.
- 2003. Mouse Models of Cancer. Conference. III South American Conference of Veterinary Medicine. Rio de Janeiro, BR.
- 2003. Mouse Genome Sequence. Conference. III South American Conference of Veterinary Medicine. Rio de Janeiro, BR.
- 2003. Genetic Monitoring of Inbred Mice and Rats. Conference. III South American Conference of Veterinary Medicine. Rio de Janeiro, BR.
- 2000. Gene Mapping in the Mouse. Conference. XXI Brazilian Congress of Veterinary Clinics of Small Animals, South American Conference of Veterinary Medicine. Rio de Janeiro, BR.
Formal Peers
- 2023. Laboratory Mice: past, present and future. Invited. Laboratory Mice: past, present and future. VIRTUAL, CO.
- 2023. Other rodents in biomedical research. Invited. Other rodents in biomedical research. Mexico City, MX.
- 2023. Substrains of inbred mice and rats. Invited. Substrains of inbred mice and rats. VIRTUAL, AR.
- 2023. Substrains of inbred mice and rats. Invited. Substrains of inbred mice and rats. VIRTUAL, SE.
- 2022. Spontaneous mutations as mouse models. Invited. Spontaneous mutations as mouse models. VIRTUAL, BR.
- 2022. Spontaneous mutations as mouse models. Invited. Spontaneous mutations as mouse models. VIRTUAL, CO.
- 2022. Genetically standardized strains of mice and rats (VIRTUAL). Invited. Genetically standardized strains of mice and rats (VIRTUAL). Mexico DF, MX.
- 2021. Introduction of Rodent Genetics (VIRTUAL). Invited. Introduction of Rodent Genetics (VIRTUAL). Montevideo, UY.
- 2021. Introduction of Rodent Genetics (VIRTUAL). Invited. Introduction of Rodent Genetics (VIRTUAL). Sao Paulo, BR.
- 2021. Genetic monitoring of inbred strains (VIRTUAL). Invited. Genetic monitoring of inbred strains (VIRTUAL), AR.
- 2021. Substrains of inbred mice and rats (VIRTUAL). Invited. Substrains of inbred mice and rats (VIRTUAL). VIRTUAL, CL.
- 2021. Genetic quality controls in inbred mice and rats (VIRTUAL). Invited. Genetic quality controls in inbred mice and rats (VIRTUAL), BR.
- 2021. Mouse models of cancer (VIRTUAL). Invited. Mouse models of cancer (VIRTUAL). Bellaterra, ES.
- 2020. Genetic quality controls in inbred mice and rats (VIRTUAL). Invited. Genetic quality controls in inbred mice and rats (VIRTUAL). Santiago de Chile, CL.
- 2020. Introduction of Rodent Genetics and Positional Cloning of Mouse Mutations (VIRTUAL). Invited. Introduction of Rodent Genetics and Positional Cloning of Mouse Mutations (VIRTUAL). Montevideo, US.
- 2020. Introduction of Rodent Genetics and Standardized Strains of Laboratory Rats and Mice (VIRTUAL). Invited. Introduction of Rodent Genetics and Standardized Strains of Laboratory Rats and Mice (VIRTUAL). Latin America, US.
- 2020. Genetic quality controls in inbred mice and rats (VIRTUAL). Invited. Genetic quality controls in inbred mice and rats (VIRTUAL). Virtual, US.
- 2020. Genetic quality controls in inbred mice and rats (VIRTUAL). Invited. Genetic quality controls in inbred mice and rats (VIRTUAL). Virtual, BR.
- 2020. Introduction to rodent genetics and Mouse models of cancer (VIRTUAL). Invited. Introduction to rodent genetics and Mouse models of cancer (VIRTUAL). Virtual, AR.
- 2019. Laboratory Rodents: past, present, and future. Invited. Laboratory Rodents: past, present, and future. Montevideo, UY.
- 2019. Mouse models of cancer. Invited. Mouse models of cancer. Buenos Aires, AR.
- 2019. The Importance of Genetic Background in Mouse Models. Invited. The Importance of Genetic Background in Mouse Models. Madrid, ES.
- 2019. Of mutant mice and genes: forward genetics is not dead. Invited. Of mutant mice and ganes: forward genetics is not dead. Madrid, ES.
- 2019. I Workshop on Laboratory Animal Science: Genetic Quality Control of Inbred Strains of Rodents. Invited. I Workshop on Laboratory Animal Science: Genetic Quality Control of Inbred Strains of Rodents. Uberlandia, BR.
- 2019. I Workshop on Laboratory Animal Science: Introduction to Mouse Genetics; Genetic Quality Control of Inbred Strains of Rodents, Part 1. Invited. I Workshop on Laboratory Animal Science: Introduction to Mouse Genetics; Genetic Quality Control of Inbred Strains of Rodents, Part 1. Uberlandia, BR.
- 2019. The Importance of Genetic Background in Mouse Models. Invited. The Importance of Genetic Background in Mouse Models. Boston, MA, US.
- 2019. Functioning of an IACUC (VIRTUAL). Invited. Functioning of an IACUC (VIRTUAL). Montevideo, UY.
- 2019. Webinar Series on Rodent Genetics. Invited. Webinar Series on Rodent Genetics. Dublin, IE.
- 2018. Inbred mice, identical but different: the devil is in the details. Invited. Inbred mice, identical but different: the devil is in the details. Barcelona, ES.
- 2018. Of mice and games: forward genetics is not dead. Invited. Of mice and ganes: forward genetics is not dead. Buenos Aires, AR.
- 2018. Webinar Series on Rodent Genetics. Invited. Webinar Series on Rodent Genetics. Dublin, IE.
- 2017. Importance of Genetic Background in Mouse and Rat Models. Invited. Importance of Genetic Background in Mouse and Rat Models. College Station, US.
- 2017. Importance of Genetic Background in Mouse Models. Invited. Importance of Genetic Backgorund in Mouse Models. San Diego, CA, US.
- 2017. Inbred mice, identical but different: the devil is in the details. Invited. Inbred mice, identical but different: the devil is in the details. Austin, TX, US.
- 2016. Importance of Genetic Background in Mouse Models. Invited. Importance of Genetic Background in Mouse Models. Buenos Aires, AR.
- 2016. The Value of Working with Spontaneous Mouse Mutations. Invited. The Value of Working with Spontaneous Mouse Mutations. Paris, FR.
- 2015. Importance of Genetic Background in Mouse Models. Invited. Importance of Genetic Background in Mouse Models. Buenos Aires, AR.
- 2014. The Lrrc8a
mouse mutation. Invited. The Lrrc8a mouse mutation. Paris, FR. - 2013. The value of spontaneous mouse mutations. Invited. The value of spontaneous mouse mutations. Madrid, ES.
- 2013. The value of spontaneous mouse mutations. Invited. The value of spontaneous mouse mutations. Madrid, ES.
- 2012. The Importance of Genetic Background in Mouse and Rat Models. Invited. The Importance of Genetic Background in Mouse and Rat Models. Albuquerque, NM, US.
- 2010. From Phenotype to Genotype: Forward Genetics Using Spontaneous Mouse Mutations. Invited. From Phenotype to Genotype: Forward Genetics Using Spontaneous Mouse Mutations. College Station, TX, US.
- 2010. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I. Invited. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I. Paris, FR.
- 2010. The Importance of Genetic Background in Mouse and Rat Models. Invited. The Importance of Genetic Background in Mouse and Rat Models. Barcelona, ES.
- 2009. From Mutant Mouse Skin to Animal Models (forward genetics). Invited. From Mutant Mouse Skin to Animal Models (forward genetics). Davis, CA, US.
- 2004. The mouse nackt mutation as a model in cancer research. Invited. The mouse nackt mutation as a model in cancer research. College Station, TX, US.
- 2004. The mouse nackt mutation as a model in cancer research. Invited. The mouse nackt mutation as a model in cancer research. Bethesda, MD, US.
- 2001. The nackt mutation. Invited. The nackt mutation. Charlottesville, VA, US.
- 2001. The nackt mutation. Invited. The nackt mutation. Paris, FR.
- 2000. Genetic Monitoring of Laboratory Animals in South America. Invited. Genetic Monitoring of Laboratory Animals in South America. Dallas, TX, US.
- 1999. nackt: a new mutation of the mouse with associated CD4 deficiency. Invited. nackt: a new mutation of the mouse with associated CD4 deficiency. Bar Harbor, ME, US.
- 1997. Laboratory Animals: an introduction. Invited. Laboratory Animals: an introduction. Buenos Aires, AR.
- 1997. DNA polymorphisms: their use as molecular markers in Experimental Oncology. Invited. DNA polymorphisms: their use as molecular markers in Experimental Oncology. Buenos Aires, AR.
- 1996. Molecular Genetics of Cancer. Invited. Molecular Genetics of Cancer. Buenos Aires, AR.
- 1996. Mutant Mice in Experimental Immunology. Invited. Mutant Mice in Experimental Immunology. Buenos Aires, AR.
Patient Reviews
CV information above last modified March 31, 2025