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Frederick F. Lang, M.D., FACS, FAANS, FAAAS

Department of Neurosurgery, Division of Surgery

About Dr. Lang

Frederick Lang, M.D., FACS, FAANS, FAAAS is Professor and Chairman of the Department of Neurosurgery at MD Anderson. He is also Adjunct Professor of Neurosurgery at Baylor College of Medicine, Houston. Dr. Lang was born in Brooklyn, NY. He received his medical degree from Yale University School of Medicine, New Haven, CT. He completed a residency in neurosurgery at New York University Medical Center, and a fellowship in neurosurgical oncology at MD Anderson. Dr. Lang is the recipient of numerous awards and honors, including America's Top Doctors for Cancer, Guide to America's Top Surgeons, the Preuss Research Award, the Mahaley Award, the Journal of Neuro-Oncology Award, the Michael S. Voynick Award in Neuro-Oncology, the Perlman Lectureship, and the Otto Lein da Wong Lecture from the Chinese University of Hong Kong. He is the Principal Investigator of the multi-disciplinary SPORE in Brain Cancer Program grant. He is a NIH-funded translational researcher who has published extensively on gene, viral and cellular therapies for brain tumors and is Principal Investigator on multiple clinical trials that investigate these new approaches. He has served on the Executive Committee of the AANS/CNS Section on Tumors and is the past Chair of this section. He is a member of the Board of Directors of the Society for Neuro-Oncology (SNO), and is a past President of SNO. He is board certified in Neurosurgery and is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Dr. Lang is an Associate Editor of Neurosurgery and on the Editorial Board of Neuro-Oncology and Translational Oncology. He served on the Developmental Therapeutic Study Section within the NIH until his tenure ended in 2011, he has continued as an ad hoc reviewer for NIH. He is frequently requested as a national and international lecturer. He has published more than 200 peer-reviewed articles and book chapters. Dr. Lang is a leader in the field of neurosurgery with particular focus on deep seated brain tumors located in eloquent brain regions.

Meet Frederick Lang, M.D.

In the News

Targeting cells that form blood vessels in glioblastoma could improve treatment

Craniotomy vs. craniectomy: What’s the difference?

When Gary Guthrie’s melanoma skin cancer spread to his brain, he and his wife, Leslie, turned to MD Anderson’s Brain Metastases Clinic for help..

New clinic expands brain metastasis treatment options

Smart bomb virus shows promise as brain tumor immunotherapy

Present Title & Affiliation

Primary Appointment

Co-Director, Department of Cancer Neuroscience Program, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Endowed Distinguished University Chair Raymond Sawaya, M.D. Distinguished University Chair, The University of Texas MD Anderson Cancer Center, Houston, TX

Co-Director, Department of Andrew McDougal Brain Metastasis Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX

Co-Director, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX

Chair, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Faculty Member, MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX

Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Dual/Joint/Adjunct Appointment

Raymond Sawaya, M.D. Distinguished University Chair, The University of Texas MD Anderson Cancer Center, Houston, TX

Chairman, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Faculty Member, MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX

Professor (tenure), Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Education & Training

Degree-Granting Education

1988	Yale University School of Medicine, New Haven, Connecticut, US, MD
1984	Yale College, Yale University, New Haven, Connecticut, US, Biology, BS

Postgraduate Training

1995-1996	Clinical Fellowship, Neurosurgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
1993-1995	Clinical Residency, Chief Resident, Department of Neurosurgery, New York University Medical Center, New York, New York
1989-1993	Clinical Residency, Department of Neurosurgery, New York University Medical Center, New York, New York
1988-1989	Clinical Internship, General Surgery, New York University Medical Center, New York, New York

Licenses & Certifications

2024	Mississippi State Board of Medical Licensure
2024	Arizona Board of Medical Examiners
2024	Tennessee Board of Medical Examiners
2024	Oklahoma State Board of Medical Licensure
2024	Washington State Department of Health
2024	Louisiana State Board of Medical Examiners
2024	Alabama Board of Medical Examiners
2024	Georgia Composite Medical Board
2021	Florida Board of Medicine
2000	The American Board of Neurological Surgery
1996	Texas Medical Board
1989	New York Medical License

Experience & Service

Faculty Academic Appointments

Professor, Department of Cancer Biology, Graduate School of Biomedical Sciences, Houston, TX, 2023 - 2028

Beau Biden Chair for Brain Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2021

Adjunct Associate Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 2005 - 2006

Associate Professor (tenure), Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2002 - 2006

Assistant Professor (tenure track), Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1996 - 2002

Administrative Appointments/Responsibilities

Co-Director, Department of Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present

Co-Director, Department of Andrew McDougal Brain Metastasis Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - Present

Co-Director, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - Present

Director of Clinical Research, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2000 - 2018

Other Professional Positions

Clinical Advisory Board, Cognos Therapeutics, Delaware, 2022 - Present

Scientific Advisory Board Member, PolyPid Ltd, Israel, 2021

Scientific Advisory Board Member, Nektar Therapeutics, San Francisco, CA, 2021

Scientific Advisory Board Member, Theracle, San Antonio, TX, 2019 - Present

Consultantships, InSightTec, Inc, Miami, FL, 2018 - Present

Committee Member, WFNS Neuro-Oncology Committee, Munich, 2017 - 2021

Member Clinical Advisory Board, Pharmaco-Kinesis, Inc, USA, 2009 - 2013

Member, Data Safety Monitoring Committee, Delta-24-RGD Trial in the Netherlands (PI: Dr. Dirven), Netherlands, 2008 - 2016

Consultant, Antisense Pharma, Regensburg, Germany, 2006 - 2008

Consultant, Steering Committee Member, NeoPharm Therapeutics, Inc, Houston, TX, 2004 - 2009

Alumni School Committee, Admissions Reviewer, Yale College, Yale University, New Haven, CT, 2000 - Present

Extramural Institutional Committee Activities

Member, Reach Executive Committee, The University of Texas MD Anderson Cancer Center, 2024 - 2025

Member, Institutional Patient Safety Committee, The University of Texas MD Anderson Cancer Center, 2023 - 2024

Chair, Community of Chairs, The University of Texas MD Anderson Cancer Center, 2023 - 2024

Leader, Community of Chairs Budget Subcommittee, The University of Texas MD Anderson Cancer Center, 2022

Member, Charles LeMaistre Award Committee, The University of Texas MD Anderson Cancer Center, 2022

Member, OR Advisory Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present

Member, MD Anderson Melanoma SPORE Internal Advisory Board, The University of Texas MD Anderson Cancer Center, 2021 - Present

Member, Image Guided Cancer Therapy (IGCT) T32 Training Program Advisory Steering Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present

Member, Division of Surgery Diversity, Equity, & Inclusion Executive Committee, The University of Texas MD Anderson Cancer Center, 2021 - 2023

Internal Advisor, Multidisciplinary Research Program (MRP) Grant Application, The University of Texas MD Anderson Cancer Center, 2021

Advisory Board Member, Center for Advanced Biomedical Imaging Internal Advisory Board, The University of Texas MD Anderson Cancer Center, 2021

Advisory Member, Physician Scientist Program Advisory Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present

Member, Division Head Search Committee, Department of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, 2021

Internal Reviewer, MD Anderson Melanoma Moon Shot, The University of Texas MD Anderson Cancer Center, 2021 - Present

Member, MD Anderson Cancer Center Head & Neck SPORE Internal Advisory Board, The University of Texas MD Anderson Cancer Center, 2020 - Present

Advisory Member, Computational Pathology Program Advisory Board, The University of Texas MD Anderson Cancer Center, 2020

Member, Community of Chairs Sub-Committee: Workgroup on Faculty Recruitment/Chair Package Positions & Physician Scientists, The University of Texas MD Anderson Cancer Center, 2019 - Present

Member, Operational Priority: Program Assessment, The University of Texas MD Anderson Cancer Center, 2019 - Present

Member, Search Committee, VP of Ambulatory Services, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2018

Advisory Member, Search Committee, Neuro-Oncology Chair, The University of Texas MD Anderson Cancer Center, 2018

Member, Division of Surgery Executive Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present

Member, Community of Chairs Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present

Member, Brain Metastasis Clinic Organizational Working Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present

Member, Annual Retreat Sub Committee for Diversity Inclusion, Division of Surgery, The University of Texas MD Anderson Cancer Center, 2018 - 2019

Chair, Division of Surgery Diversity, Equity, & Inclusion Committee, The University of Texas MD Anderson Cancer Center, 2018 - 2021

Member, Division of Surgery Research Committee, The University of Texas MD Anderson Cancer Center, 2016 - Present

Member, Vice Provost Advisory Council Biomarker Working Group: Enhancing the Development of Novel Biomarkers, The University of Texas MD Anderson Cancer Center, 2015

Member, Vice Provost Advisory Council-Clinical Research, The University of Texas MD Anderson Cancer Center, 2014

Member, Faculty Search Committee, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2014 - 2015

Member, Faculty Search Committee (Basic Scientist), Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 2011

Member, University of Texas MD Anderson Cancer Center Flow Cytometry and Cell Imaging Core Facility (FCCIC) Internal Advisory Board, The University of Texas MD Anderson Cancer Center, 2011

Member, Faculty Search Committee, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 2010

Member, University of Texas M.D. Anderson Cancer Center, Division of Surgery Research Council, The University of Texas MD Anderson Cancer Center, 2009

Permanent Member for the Department of Neurosurgery, Credentials Committee of the Medical Staff, The University of Texas MD Anderson Cancer Center, 2008 - 2009

Alternate Member for the Department of Neurosurgery, Credentials Committee of the Medical Staff, The University of Texas MD Anderson Cancer Center, 2006 - 2008

Member, Genomics Core Users Committee, The University of Texas MD Anderson Cancer Center, 2005 - 2017

Member, Study Section Review Committee for Clinical Translational and Population-Based Research Projects Under the Institutional Research Grants Program, The University of Texas MD Anderson Cancer Center, 2005 - 2017

Member, Welfare Committee, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2004 - 2005

Member, Division of Surgery Academic/Education Committee, The University of Texas MD Anderson Cancer Center, 2003 - 2010

Member, Faculty Search Committee, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 2003 - 2004

Chair, Translational Research/Tissue Bank Focus Group, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, 2002

Co-Chair, Clinical Research Sub-committee, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, 2002 - 2018

Member, Executive Committee, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, 2001 - 2018

Representative for Department of Neurosurgery, Faculty Senate, The University of Texas MD Anderson Cancer Center, 1999 - 2005

Representative for Department of Neurosurgery, Intensive Care Unit Committee, The University of Texas MD Anderson Cancer Center, 1999 - 2005

Member and Scientific Reviewing Agent, Clinical Research Committee, The University of Texas MD Anderson Cancer Center, 1999 - 2000

Representative for Department of Neurosurgery, Neuro Clinical Research Task Force, The University of Texas MD Anderson Cancer Center, 1999 - 2005

Physician Auditor, Protocol Research Quality Assurance, The University of Texas MD Anderson Cancer Center, 1998

Representative for Department of Neurosurgery, Tumor Registry Steering Committee, The University of Texas MD Anderson Cancer Center, 1997 - 2000

Editorial Activities

Editorial Board, Brain Tumor Research and Treatment, 2022 - Present

Editor/Service on Editorial Board(s), Oncology Letters, 2010 - Present

Editorial Board, World Neurosurgery, 2010 - 2014

Editorial Board, Translational Oncology, 2008 - Present

Editorial Board, Neuro-Oncology Journal, 2007 - 2011

Editor, Special Issue on CNS Malignancies, Journal of Clinical Oncology, 2006

Editorial Board, Self Assessment in Neurological Surgery (SANS) Lifelong Learning, 2005 - Present

Associate Editor, Neurosurgery, 1996 - Present

Honors & Awards

2024	Fellow of the Congress of Neurological Surgeons, Congress of Neurological Surgeons
2024	Castle Connolly Top Doctor 2024
2022	2022 Castle Connolly Top Doctor Recognition
2022	2022 SNS Winn Award Lecturer, Society of Neurological Surgeons
2021	President's Recognition of Faculty Excellence in Research Excellence, The University of Texas MD Anderson Cancer Center
2021 - 2024	Raymond Sawaya, M.D. Distinguished University Chair, The University of Texas MD Anderson Cancer Center
2021	Texas Top Doctors
2020	2020 Annual Andrew Connor Curtis Endowed Featured Speaker, Leonard M. Miller School of Medicine, University of Miami
2020	Honored by Journal of Clinical Oncology as a top-cited author for "Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma
2019	Otis W. and Pearl L. Walters Faculty Achievement Award in Clinical Research, The University of Texas MD Anderson Cancer Center
2018	Top Doctor, Texas by Texas Monthly
2017	Consumer Assessment of Healthcare Providers and Systems (CAHPS), Top 1% rank nationally
2017	Abhijit Guha Brain Tumor Award, AANS/CNS Joint Section on Tumors
2016	Otto Lien Da Wong Lecture in Neuro-Oncology, 13th Asian Pacific Multidisciplinary Meeting for Nervous System Diseases, Chinese University of Hong Kong, Shatin, Hong Kong, January 22-23
2016	Samuel Hassenbusch Lecturer, Texas Association of Neurological Surgeons Annual Meeting, February 18-19
2016	Robert M. Chamberlain Distinguished Mentor Award, Finalist
2015	Sandra Altman Lectureship, University of Pennsylvania School of Medicine, April 9
2015	Steve Sabol Lecture for Neurosurgical Oncology, Jefferson Medical Center Brain Tumor Symposium, Philadelphia, October 30
2015	Journal of Neuro-Oncology Award, American Association of Neurological Surgeons Annual Scientific Meeting
2014	Ronald L. Bittner Lecture, 82nd American Association of Neurological Surgeons Annual Scientific Meeting
2013	Certificate of appreciation for "Exceptional leadership and support as a mentor at The University of Texas MD Anderson Cancer Center, MD Anderson Alumni & Faculty Association
2013	Arthur & Sonia Labatt Brain Tumour Research Centre Academic Lecture, Toronto, Canada, February 7
2013	Certificate of appreciation in recognition of leadership and devoted service, American Association of Neurological Surgeons, Ex-Officio for Section on Tumors
2012	Waun Ki Hong Award for Excellence in Team Science, 7th Annual Division of Cancer Medicine Faculty Recognition and Awards Program, MD Anderson Cancer Center
2012	Mahaley Award, American Association of Neurological Surgeons
2011	Texas Super Doctors
2010	Michael S. Voynick Lecture Award, Yale Medical School
2009	Houston's Top Doctors, 2006
2009	International Who's Who of Professionals
2009 - 2012	Who's Who Among Executives and Professionals Throughout the World
2008 - 2012	Who's Who in America
2008	Guide to America's Top Surgeons
2007	Certificate of appreciation for outstanding service and significant contributions, Executive Committee of the AANS/CNS Section on Tumors
2007	Global Directory of Who's Who
2004 - 2006	Guide to America's Top Physicians
2004	21st Century Award for Achievement
2004	America's Top Doctors for Cancer
2003	Best Doctors in America
1998	Young Clinician Investigator Award, American Association of Neurological Surgeons
1993	Preuss Resident Research Award, Joint Section on Tumors of the American Association of Neurological Surgeons
1988	Merck Book Award for Outstanding Medical Graduate
1988	Graduated Cum Laude, Yale School of Medicine
1988	Alpha Omega Alpha Honorary Society
1988	Harold Lamport Research Prize for Outstanding Medical Thesis
1984	Graduated Summa Cum Laude with Honors in the Major (Biology), Yale College
1983	Phi Beta Kappa Honor Society

Professional Memberships

Society of Neurological Surgeons

2023 - Present

Society of University Neurosurgeons

2019 - Present

The Royal Society of Medicine

2017 - Present

European Organization for Research and Treatment of Cancer (EORTC) Protocol Review Committee (PRC)

2017 - Present

National Cancer Institute (NCI) Brain Malignancies Steering Committee

2014 - Present

Neurosurgery Research & Education Foundation (NREF)

2014 - Present

European Association of Neuro-Oncology (EANO)

2012 - Present

Accreditation Council for Graduate Medical Education Neurological Surgery Milestone Project Working Group

2011 - Present

American Academy of Neurological Surgery

2011 - Present

Society of Neurological Surgeons

2009 - Present

American Society of Clinical Oncology

2007 - Present

Radiation Therapy Oncology Group

2005

American Association of Neurological Surgeons and Congress of Neurological Surgeons Standing Committee, Self Assessment for Neurosurgery (SANS) Wired Committee

2004 - 2005

American College of Surgeons Oncology Group

2003 - 2004

Children's Oncology Group

2002 - Present

American Board of Neurological Surgery

2001 - 2005

Neuro-Oncology for the Residency Training Program, The University of Texas Medical Branch at Galveston

2001 - 2002

American College of Surgeons

2001 - Present

American Association of Neurological Surgeons/Congress of Neurological Surgeons, Joint Section on Tumors

1998 - Present

American Association of Cancer Research

1997 - Present

American Association for the Advancement of Science

1997 - Present

Texas Association of Neurological Surgeons

1997 - Present

Society for Neuro-Oncology

1997 - Present

North American Skull Base Society

1997 - 2000

North American Brain Tumor Consortium

1997 - Present

Houston Neurological Society

1997 - Present

Harris County Medical Society

1997 - Present

Congress of Neurological Surgeons

1997 - Present

American Association of Neurological Surgeons

1996 - Present

Selected Presentations & Talks

Local Presentations

2024. "Glioblastoma". Invited. SNIS Neurointerventional Oncology Summit. Houston, TX, US.
2022. "Glioblastoma". Conference. GBM Moonshots Program Scientific Advisory Board Meeting, MD Anderson Cancer Center. Virtual, US.
2022. "Neurological Health". Conference. Making Cancer History Seminar Series. Virtual, US.
2022. "Cancer Neurosciences Program". Conference. Research Town Hall. Virtual, US.
2021. "Window of Opportunity Trials". Conference. Fellows' Clinical Trials Design Course Series. Virtual, US.
2021. "Glioblastoma Moonshot SAB Presentation". Conference. GBM Moonshots Program Scientific Advisory Board Meeting. Virtual, US.
2021. "Introduction to Catalyst: A Tumor Analysis Pipeline". Conference. Institutional Grand Rounds, Department of Neurosurgery: Novel Clinical Trials and Protocols. Virtual, US.
2020. "Window of Opportunity Trials & Alternative Trial Designs". Conference. Fellows' Clinical Trials Design Course Series, The University of Texas MD Anderson Cancer Center, August 14. Houston, TX, US.
2020. “Endovascular Treatment of Gliomas: Bone Marrow Stem Cell Delivery of Delta-24-RGD”. Conference. MD Anderson Brain Tumor Program Seminar Series. Houston, TX, US.
2020. "Pineal Region Tumors". Conference. Department of Neurosurgery Clinical Neurosciences Seminar. Houston, TX, US.
2020. "Brain SPORE Project 1: Oncolytic Adenoviruses for Glioma Therapy". Conference. MD Anderson Cancer Center Thematic SPORE Symposium. Houston, TX, US.
2019. "Project 1: Oncolytic Adenoviruses for Glioma Therapy". Conference. Brain Cancer SPORE Leadership Retreat. Houston, TX, US.
2019. "Establishment of the Brain Metastasis Clinic". Conference. Brain Metastasis Scientific Retreat, State of the Science Symposium, MD Anderson Cancer Center. Houston, TX, US.
2019. "Biological Therapies for Gliomas: Viruses and Stem Cells". Conference. MD Anderson Cancer Center Global Academic Programs Special Session, Taming Glioblastoma: Is It Possible? In Memory of John Mendelsohn, MD. Houston, TX, US.
2019. "Clinical Aspects of the Management of Patients with Brain Metastases: Development of Brain Metastasis Center at MD Anderson". Conference. Global Academic Programs Advances in the Understanding and Management of Brain Metastasis Scientific Session, MD Anderson Cancer Center. Houston, TX, US.
2019. "Pineal Region Tumors". Conference. Clinical Neuroscience Lecture Series, MD Anderson Cancer Center. Houston, TX, US.
2018. "History of MDACC and Sawaya Legacy". Invited. AANS/CNS Tumor Section Satellite Symposium. Houston, TX, US.
2018. "Building a Trial out of Things You Do Every Day (Lumbar Drain, AEDs, etc.)". Invited. AANS/CNS Tumor Section Satellite Symposium. Houston, TX, US.
2018. "Low-Grade Gliomas". Invited. Contemporary Management and Guidelines for Incidentally Found Tumors Session, Congress of Neurological Surgeons Annual Meeting, October 6-10. Houston, TX, US.
2018. "The Life of a Neurosurgeon". Conference. The Brain Tumor Center Summer Student Seminar Series, MD Anderson Cancer Center. Houston, TX, US.
2018. "Mesenchymal Stem Cells as Biological Therapies for Brain Tumors". Conference. Cell Therapy Retreat, New Therapeutic Tools for Cell Therapies Session, MD Anderson Cancer Center. Houston, TX, US.
2018. "MSC-derived exosomes carrying microRNAs in the treatment of human gliomas". Invited. The Society of University Neurosurgeons Annual Meeting. Houston, TX, US.
2018. "Innovative Therapies for Glioma: The Delta-24-RGD Oncolytic Adenovirus". Invited. The Society of University Neurosurgeons Annual Meeting. Houston, TX, US.
2018. "Brain SPORE Highlights". Conference. Brain Tumor Center Research Retreat 2018 Program, MD Anderson Cancer Center. Houston, TX, US.
2018. "Endovascular Neurosurgical Oncology: A New Frontier in Brain Tumor Therapy". Conference. Brain Tumor Center Research Retreat 2018 Program. GBM: Viral Therapy Updates Session, MD Anderson Cancer Center. Houston, TX, US.
2017. "Enhanced Surgical Recovery Pathway in Brain Surgery". Conference. 5th Global Conference on Perioperative Care of the Cancer Patient: Bending the Acute Care Cost Curve and Improving Outcomes. Enhanced Recovery Programs-Patient Centric Care Session, MD Anderson Cancer Center and Global Partners. Houston, TX, US.
2017. "Brain Cancer SPORE: A Team Effort". Conference. Training in Brain Tumor Research Seminar, MD Anderson Cancer Center. Houston, TX, US.
2017. "SPORE in Brain Cancer". Conference. Brain Tumor Center Research Retreat, MD Anderson Cancer Center. Houston, TX, US.
2016. "Oncolytic Viro-Immunotherapy: Animal Model Innovations". Conference. Division of Cancer Medicine Grand Rounds, GBM Moonshot Program Arising Innovation from the GBM Moonshot, MD Anderson Cancer Center. Houston, TX, US.
2016. "Exosomes in the Biology and Therapy of Human Gliomas". Conference. Exosome Biology Think Tank, MD Anderson Cancer Center GBM Moonshot Program. Houston, TX, US.
2016. "Arising Innovation From the GBM Moon Shot: Exploiting Biological Therapies for Brain Tumors". Conference. Institutional Grand Rounds, Advances in Oncology, MD Anderson Cancer Center. Houston, TX, US.
2016. "Glioblastoma". Conference. GBM Moonshots Program Scientific Advisory Board Meeting, MD Anderson Cancer Center. Houston, TX, US.
2015. "Brain Tumor Research Update". Conference. Broach Foundation for Brain Tumor Research. Houston, TX, US.
2015. "Exosomes in the Therapy and Biology of Gliomas". Conference. Institutional Grand Rounds, Advances in Oncology Panel Discussion, The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2014. "Neurosurgery as a Career". Conference. Strake Jesuit High School, Neurobiology Association. Houston, TX, US.
2014. "The MDACC Brain Cancer SPORE: An Update". Conference. Training in Brain Tumor Research Seminars, MD Anderson Cancer Center. Houston, TX, US.
2013. "Delta-24-RGD Oncolytic Virotherapy: Clinical and Laboratory Advances". Conference. Institutional Grand Rounds, The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2013. "A Phase I Trial of Delta-24-RGD: Clinical and Biological Results". Conference. Institutional Grand Rounds, The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2012. "Clinical Infrastructure: Early Detection/Imaging/Biomarkers Strategy". Conference. Brain Tumor Program Strategic Retreat, The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2010. "Overview: Neurosurgery". Conference. Neurosurgery and Neuro-Oncology EAB Review. Houston, TX, US.
2010. "Institutionally Developed Paradigms of Translational Research: Delta-24". Conference. Neurosurgery and Neuro-Oncology EAB Review. Houston, TX, US.
2010. "Clinical Research Summary". Conference. Neurosurgery and Neuro-Oncology EAB Review. Houston, TX, US.
2010. "Primary Brain Tumors". Conference. Neurosurgery and Neuro-Oncology EAB Review. Houston, TX, US.
2010. "Tumor Microenvironment". Conference. Neurosurgery and Neuro-Oncology EAB Review. Houston, TX, US.
2009. "Surgical Management Stage IV Breast Cancer". Conference. Surgical Oncology Fellows Conference, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2009. "Potential of Mesenchymal Stem Cells in Clinical Trials of Gliomas". Conference. Brain Tumor Center Research Retreat, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2009. "Trials Using Biological Vectors: Lessons Learned". Conference. Brain Tumor Center Research Retreat, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2009. "Cerebral Tumors and Other Lesions". Invited. American Association of Neurological Surgeons Weekend Update: Interactive Review of Clinical Neurosurgery by Case Management. Scottsdale, AZ, US.
2009. "Targeting Gliomas with Biological Therapies: Mesenchymal Stem Cells to Deliver Delta-24-RGD to Gliomas". Conference. Center for Targeted Therapy Award Research Seminar, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2008. "A New Orthotopic Murine Model of Spinal Metastasis: Histological Correlates and Therapeutic Applications". Conference. Trainee Recognition Day Program, The University of Texas MD Anderson Cancer Center. * Won the Amgen Award. Houston, TX, US.
2008. "Insular Tumors and Awake Craniotomies". Conference. 2nd Annual Kempfer Nurses' Conference. Houston, TX, US.
2007. "Surgical Management of Brain Metastases from Breast Cancer". Conference. Surgical Oncology Fellows Educational Series, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2007. "Metastatic Brain Tumors". Conference. Neuro-Oncology Core Curriculum Lecture Series, The University of Texas M.D. Anderson Cancer Center. Houston, TX, US.
2007. "Insular Tumors and Awake Craniotomy". Conference. Nurse's Functional Brain Anatomy Seminar, The University of Texas M.D. Anderson Cancer Center at Baylor College of Medicine. Houston, TX, US.
2006. "Bone Marrow Stem Cells in Treatment of Gliomas". Conference. Baylor College of Medicine Texas Children's Cancer Center, Diagnosis and Therapeutic Discovery in Neuro-Oncology Conference. Houston, TX, US.
2004. "Generation of Central Nervous (CNS) Tissue Cells from Adult PB and Umbilical Cord Blood Hematopoietic Stem Cells Using a Xenogeneic Transplant Model". Conference. Stem Cell Research Retreat, The Houstonian Hotel. Houston, TX, US.
2002. "Gene and Viral Therapy for Human Gliomas". Invited. 2002 Texas Medical Center Gene Therapy Symposium. Houston, TX, US.
2002. "Neurosurgery/Neuro-Oncology Research Initiatives". Invited. Golfers Against Cancer Site Visit Committee. Houston, TX, US.
2002. "Gene and Viral Therapy: An Evolving Story". Invited. 5th Foundations of Clinical Cancer Research Symposium, The M.D. Anderson Model of Patient Care. Houston, TX, US.
2001. "Brain Tumor Therapy: Challenges & Solutions". Invited. Golfers Against Cancer Group. Houston, TX, US.
2001. "Phase I Clinical Trial of Adenovirus-mediated p53 Gene Therapy for Recurrent Gliomas: A Paradigm for Assessing Biological Agents". Invited. Neurosurgical Oncology Symposium: The Decade Ahead. Houston, TX, US.
1999. "Protocol NABTC-9703: Phase I Trial of Adenovirus-Mediated Wild-Type p53 Gene Therapy for Malignant Gliomas". Invited. 1999 Texas Medical Center Gene Therapy Symposium. Houston, TX, US.
1999. "Current Therapies for Pediatric Brain Tumors". Invited. Together in Hope Conference. Houston, TX, US.
1997. "The Effects of Combined p53 Gene Therapy and Adjuvant Irradiation in the Treatment of Human Gliomas". Conference. The University of Texas M. D. Anderson Cancer Center, Round Top, Department of Experimental Radiation Oncology Workshop on Gene Therapy. Houston, TX, US.
1997. "Current Controversies in the Treatment of Single and Multiple Brain Metastases". Invited. The 40th Annual Clinical Conference: Cancer and the Central Nervous System. Houston, TX, US.
1997. "Taking Control". Invited. Brain Tumor Patient Conference. Houston, TX, US.

Regional Presentations

2026. "Novel Biological Therapeutics for High Grade Gliomas". Invited. Texas Association of Neurological Surgeons Annual Conference 2026. Houston, Texas, US.
2024. "Biological Therapies for Brain Tumors". Visiting. Neurosurgery Grand Rounds. Austin, Texas, US.
2022. "Pineal Region Tumors". Conference. Department of Neurosurgery Clinical Neurosciences Lecture Series. Virtual, US.
2013. "Mesenchymal stem cells in the treatment and biology of gliomas". Invited. International Combined Chromosome 19 Proteomics Consortium and the 3rd Mini-Symposium on Brain Malignancies at the University of Texas Medical Branch (UTMB). Galveston, TX, US.
2007. "Adjuvant Radiotherapy After Surgical Resection of Single Brain Metastases: An Analysis of 358 Patients by Primary Tumor Site". Invited. 12th Annual Meeting of the Society for Neuro-Oncology, Plenary Session. Dallas, TX, US.
2002. "Gene and Viral Therapies for Gliomas: Novel Treatment Strategies". Invited. Texas Association of Neurological Surgeons Annual Meeting. Dallas, TX, US.

National Presentations

2025. Phase I trial of mesenchymal stem cells carrying Delta-24-RGD given intraarterially in recurrent glioma: Early report. Conference. 30th Annual Meeting of the Society for Neuro-Oncology. Honolulu, Hawaii, US.
2025. "Endovascular Surgical Neurooncology". Invited. Congress of Neurological Surgeons 2025 Annual Meeting. Los Angeles, California, US.
2025. "Biological Therapies for Brain Tumors". Invited. Cold Spring Harbor Brain Tumor Meeting. Cold Spring Harbor, NY, US.
2025. "Biological therapies for Brain tumors". Invited. Annual Melvyn M. Gelch, M.D. Lecture. Providence, Rhode Island, US.
2025. "The Perivascular Niche and Mesenchymal Stem Cells in Gliomas". Invited. 2025 Elizabeth Crosby and 12th Annual Resident Research Symposium. Ann Arbor, Michigan, US.
2025. "Microsurgery of Insular Glioma". Conference. The 2nd Congress of the Yaşargil Microneurosurgical Academy. Boston, Massachusetts, US.
2024. "Oncolytic adenoviral infection synergizes with immune checkpoint inhibition to mediate intracranial tumor control in disparate models of melanoma brain metastases.". Conference. Society for Neuro-Oncology. Houston, TX, US.
2024. "Oncolytic adenoviral infection of chordoma achieves treatment efficacy through immunogenic cell death and tumor microenvironment alteration.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "EXTH-55 | Anti-tumor activity of a new oncolytic adenovirus Delta-24-RGDOX-IL15 co-expressing OX40L and IL-15". Conference. Society for Neuro-Oncology. Houston, TX, US.
2024. "Differential DNA methylation patterns in the CSF of patients with diffuse gliomas.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Acetylation Suppression Meets Oncolytic Viruses for the Treatment of Pediatric Diffuse Midline Glioma.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Integrating spatially resolved multi-omics data to uncover dysfunctional metabolism driven networks that enhance infiltration of diffuse gliomas.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Winning the tug of war between virus and tumor immunodominance in gliomas treated with oncolytic adenoviruses using tolerogenic strategies.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Longitudinal single-cell RNA sequencing unveils phenotypic co-option and lineage traits of mesenchymal glioblastoma and glioma-associated fibroblasts.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Role of neurotransmitters in glioblastoma pathophysiology: Emerging insights.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "CSF ctDNA Analysis of Patients with Diffuse Gliomas Reveals Diagnostic Molecular Alterations". Conference. Society for Neuro-Oncology. Houston, TX, US.
2024. "Exploring CSF MicroRNA Signatures as Diagnostic Biomarkers in IDH-wildtype Diffuse Gliomas.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Enhancing therapeutic approaches in high-grade gliomas: synergistic effects of LSD1 and kinase inhibition.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Anti-tumor activity of a new oncolytic adenovirus Delta-24-RGDOX-IL15 co-expressing OX40L and IL-15.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Neurocognitive outcome following awake craniotomy for insular glioma resection: Impact of surgical approach and tumor classification.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Transcriptional heterogeneity and mechanistic pathways of recurrent Glioblastoma: Insights from a pre-clinical recurrent tumor model.". Poster. Society for Neuro-Oncology. Houston, TX, US.
2024. "Exploring CSF MicroRNA Signatures as Diagnostic Biomarkers in IDH-wildtype Diffuse Gliomas". Conference. Society for Neuro-Oncology. Houston, TX, US.
2024. "Delta-24-RGD Adenoviral Therapy: From Oncolysis to Immunotherapy and Delivery". Invited. Cold Springs Harbor Laboratory. Cold Springs Harbor, NY, US.
2024. "Utility of Postoperative CT scan Following Stereotactic Brain Biopsy". Poster. American Association of Neurological Surgeons 2024 Annual Meeting. Chicago, IL, US.
2023. "Endovascular Selective Intra-arterial Delivery of Oncolytic Viruses for Treatment of Glioma". Invited. Intraoperative Imaging Society. Park City, UT, US.
2023. "Ventricular Entry and Postoperative Leptomeningeal Disease After Resection of Supratentorial Glioblastoma". Conference. Congress of Neurological Surgeons. Washington, DC, US.
2023. "Survival Outcome Following Ventricle Entry During Resection of Supratentorial Glioblastoma". Conference. Congress of Neurological Surgeons. Washington, DC, US.
2022. "Development of Oncolytic Therapies for Gliomas". Invited. Society of Neuro-Oncology Annual Meeting, Therapeutic Development in Neuro-Oncology Symposium. Tampa, FL, US.
2022. "Surgical Perspective on the Management of Human Gliomas". Invited. Cold Spring Harbor Laboratory Brain Tumors Course. Cold Spring Harbor, NY, US.
2022. "Window of Opportunity Clinical Trials: Impact on Oncolytic Virus Therapy". Conference. 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO). Chicago, IL, US.
2022. "Evolution of Biological Therapies in the Pursuit of the Elusive Cure for Glioblastoma". Invited. Society of Neurological Surgeons Winn Award Lecturer. Detroit, MI, US.
2021. "Delta-24 Adenoviral Therapy for Glioblastoma: From Bench to Bedside". Invited. 12th Annual Conference of Indian Society of Neuro-Oncology. Virtual, US.
2021. "A Novel Adenoviral-Permissive, Immunocompetent Hamster Model to Evaluate Oncolytic Adenoviral Therapy for Glioblastoma". Invited. Oncology Models Forum Annual Meeting. Virtual, US.
2021. "Overview of the Brain SPORE". Invited. Brain Cancer SPORE Mid-Winter Workshop. Virtual, US.
2020. "Invasive Properties of GSCs with Known IDH1 Status into Human Cerebral Organoids". Conference. American Association for Clinical Research Virtual Annual Meeting II, US.
2020. "Oncolytic Adenoviruses for Glioma Therapy". Invited. Brain Tumor SPORE Mid-Winter Workshop. Chicago, IL, US.
2019. "Oncolytic Viral Therapy". Invited. The Society for Neuro-Oncology & Society for CNS Interstitial Delivery of Therapeutics Joint Conference on Therapeutic Delivery to the CNS Scientific Meeting. Phoenix, AZ, US.
2019. "Principles of Viral Therapies Against Gliomas: Oncolytic & Immunological Aspects". Invited. The Society for Neuro-Oncology Scientific Meeting and Education Day, Basic Science for the Practicing Neuro-Oncologist Session. Phoenix, AZ, US.
2019. "Trials of Oncolytic Viruses: The Impact of the Neurosurgeon". Invited. The Society for Neuro-Oncology Scientific Meeting and Education Day, Sunrise Session. Phoenix, AZ, US.
2019. "Introduction of Honored Guest Speaker: Dr. Raymond Sawaya". Invited. Congress of Neurological Surgeons Annual Meeting, General Scientific Session II. San Francisco, CA, US.
2019. "Latest Developments in Brain Cancer Research". Conference. Making Cancer History Seminar, MD Anderson Cancer Center. Palm Beach, FL, US.
2019. "MD Anderson Cancer Center SPORE Updates". Invited. Brain SPORE Mid-Winter Workshop. Los Angeles, CA, US.
2018. "Status of Oncolytic Viral Therapies in Brain Tumors: GBM". Invited. National Brain Tumor Society Research Roundtable Meeting. Washington, DC, US.
2018. "Biological Therapies for Brain Tumors". Invited. NCI Cancer Systems Biology Consortium and Physical Sciences Oncology Network Annual Meeting. Bethesda, MD, US.
2018. "Oncolytic Adenoviruses: Clinical Trials & the Delivery Problem". Invited. Section on Tumors II Symposium, The 86th American Association of Neurological Surgeons Annual Scientific Meeting. New Orleans, LA, US.
2018. "The 5 F's of Success: How to Get Where You Ought to Be". Invited. The Young Neurosurgeons Reception, The 86th American Association of Neurological Surgeons Annual Scientific Meeting. New Orleans, LA, US.
2018. "Brain SPORE at MD Anderson Cancer Center". Invited. Brain SPORE Mid-Winter Retreat. Jacksonville, FL, US.
2017. "Neurosurgery in the Age of Molecular Medicine". Invited. Congress of Neurological Surgeons Annual Scientific Meeting. Boston, MA, US.
2017. "Clinical Trials 101: What Neurosurgeons Should Know". Invited. Congress of Neurological Surgeons Annual Scientific Meeting. Boston, MA, US.
2017. "MSC-Derived Exosomes Carrying miR-124A: A Novel Treatment of Human Gliomas". Conference. 79th Annual Meeting of the American Academy of Neurological Surgery. Santa Barbara, CA, US.
2017. "Adjuvant Treatment of Gliomas". Conference. 79th Annual Meeting of the American Academy of Neurological Surgery. Santa Barbara, CA, US.
2017. "Phase 1B Open-Label Randomized Study of the Oncolytic Adenovirus DNX-2401 Administered With or Without Interferon Gamma for Recurrent Glioblastoma". Conference. American Society of Clinical Oncology Annual Meeting. Chicago, IL, US.
2017. "MD Anderson Cancer Center Brain Cancer SPORE Overview". Invited. 13th Annual Brain Cancer SPORE Mid-Winter Meeting. Raleigh, NC, US.
2016. "Surgical Interventions in the Era of Precision Medicine". Invited. 21st Annual Meeting & Education Day of the Society for Neuro-Oncology. Scottsdale, AZ, US.
2016. "Insular Tumors, Low Grade Glioma Current Management Strategies". Invited. Congress of Neurological Surgeons Annual Scientific Meeting, Luncheon Seminar. San Diego, CA, US.
2016. "Targeting the FGFR3-TACC3 Fusion in Glioblastoma: Toward Personalized Medicine". Conference. 78th American Academy of Neurological Surgery Annual Meeting. Jackson Hole, WY, US.
2016. "Exploiting biological therapies for brain tumors". Invited. Texas Association of Neurological Surgeons Annual Meeting. Fort Worth, TX, US.
2015. "Optimal Management for a Single Intracranial Metastasis: Radiosurgery or Surgery". Invited. Congress of Neurological Surgeons Annual Meeting, Luncheon Seminar. New Orleans, LA, US.
2015. "Insular Gliomas". Invited. Section on Tumors I Surgery Session, 83rd American Association of Neurological Surgeons Annual Scientific Meeting. Washington, DC, US.
2015. "SPORE in Brain Cancer Translational Research Efforts". Invited. NCI Brain Malignancies Steering Committee InterSPORE Conference. Chicago, IL, US.
2015. "Current Treatments of GBM". Invited. Spectrum of Adjuvant Therapy for Brain Tumors Symposium, 83rd American Association of Neurological Surgeons Annual Scientific Meeting. Washington, DC, US.
2015. "Phase I Clinical Trial of Oncolytic Delta-24-RGD with Biological Endpoints - Implications for Viro-Immunotherapy". Invited. 83rd American Association of Neurological Surgeons Annual Scientific Meeting. Washington, DC, US.
2015. "Surgical Resection of Insular Tumors". Invited. Low Grade Glioma I Symposium, 83rd American Association of Neurological Surgeons Annual Scientific Meeting. Washington, DC, US.
2015. "Importance of Surgically Based Clinical Trials". Invited. AANS/CNS Section on Tumors 11th Biennial Satellite Symposium. Washington, DC, US.
2015. "Pre-Test and Review of Tumor, Skull Base Studies". Invited. MOC Preparation & Neurosurgical Update: Interactive Case-Based Review Course. Las Vegas, NV, US.
2015. "Tumor and Other Cranial Lesions". Invited. MOC Preparation & Neurosurgical Update: Interactive Case-Based Review Course. Las Vegas, NV, US.
2014. "Phase I clinical trial of oncolytic virus Delta-24-RGD (DNX-2401) with biological endpoints: Implications for viro- immunotherapy". Invited. 19th Annual Scientific Meeting of the Society for Neuro-Oncology. Miami, FL, US.
2014. "Biological Therapies for Brain Tumors: Exploiting Genes, Viruses & Stem Cells". Invited. Ronald L. Bittner Lecture, 82nd American Association of Neurological Surgeons Annual Scientific Meeting. San Francisco, CA, US.
2014. "Microsurgical Techniques for Insular Gliomas". Invited. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, Low Grade Gliomas Dinner Symposium III. San Francisco, CA, US.
2012. "Surgical management of tumors in eloquent regions". Invited. Congress of Neurological Surgeons Annual Meeting, Practical Course. Chicago, IL, US.
2012. "Controversies in management of low grade gliomas". Invited. Congress of Neurological Surgeons Annual Meeting, Luncheon Seminar. Chicago, IL, US.
2012. "Viral and cellular therapy for human gliomas". Invited. Brain Tumor Biotech Summit. New York, NY, US.
2011. "Treatment algorithms for brain metastases: evidence based approaches". Invited. Congress of Neurological Surgeons, Practical Course. Washington, DC, US.
2011. "GA-MSCs increase hallmarks of glioma stem cell aggressiveness through the IL6/STAT3 pathway". Conference. 73rd Annual American Academy of Neurological Surgery. Scottsdale, AZ, US.
2011. "Surgery for Brain Metastasis". Invited. 2nd Annual International Symposium on Long-Term Control of Metastases to the Brain and Spine. Cleveland, OH, US.
2011. "Surgery vs. Radiosurgery". Invited. 2nd Annual International Symposium on Long-Term Control of Metastases to the Brain and Spine. Cleveland, OH, US.
2011. "Use of Human Bone Marrow-Derived MSCs as Vectors for Therapeutic Delivery in Malignant Glioma". Invited. American Association of Neurological Surgeons Annual Meeting. Denver, CO, US.
2010. "Whole Brain Radiotherapy: Do the Positives Outweigh the Negatives". Invited. Congress of Neurological Surgeons Annual Meeting, Dinner Seminar I: Controversies in the Management of Metastatic Brain Tumors. San Francisco, CA, US.
2010. "Clinical management of brain tumors: the surgical perspective". Invited. Mechanisms of Neural Differentiation and Brain Tumors Course, Cold Spring Harbor Laboratories. Cold Spring Harbor, NY, US.
2010. "Mesenchymal stem cells in the treatment and biology of gliomas". Invited. Plenary Session I, 7th Meeting of Asian Society for Neuro-Oncology. Seoul.
2010. "Surgery for tumors in eloquent brain". Invited. Meet the Expert Session VII, 7th Meeting of Asian Society for Neuro-Oncology. Seoul.
2010. "Current Standards of Adjuvant Cytotoxic Agents for Brain Tumors". Conference. American Association of Neurological Surgeons Annual Meeting, Breakfast Seminar: The Spectrum of Adjuvant Therapy for Brain Tumors. Philadelphia, PA, US.
2010. "Resection of Insular Gliomas". Conference. American Association of Neurological Surgeons Annual Meeting, Practical Clinic Course 019: Update on malignant brain tumors for the general neurosurgeon. Philadelphia, PA, US.
2010. "Management of Brain Metastasis: The MD Anderson Experience". Invited. Southern Neurosurgical Society Annual Meeting. Boca Raton, FL, US.
2009. "Platelet Derived Growth Factor-BB Mediates the Tropisms of Bone Marrow MSCs for Human Gliomas". Conference. American Academy of Neurological Surgery 71st Annual Meeting. Palm Beach, FL, US.
2009. "Mesenchymal Stem Cells Display Tumor Specific Tropism in a Spontaneous Brain Tumor Model". Conference. 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors. New Orleans, LA, US.
2009. "Tumor Initiation is Independent of Differentiation in Glioblastoma Stem Cells". Conference. 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors. New Orleans, LA, US.
2009. "Gene/Virotherapy Trials". Invited. 8th Annual International Symposium in Neuro-Oncology. Columbus, OH, US.
2009. "Insular Gliomas: From Anatomy to Gliomas". Conference. XIV World Congress of Neurological Surgery of the World Federation of Neurosurgical Societies. Boston, MA, US.
2009. "Human Bone Marrow-Derived MSCs for Systemic Delivery of Oncolytic Adenovirus Delta-24-RGD to Gliomas". Conference. 77th Annual Meeting of the American Association of Neurological Surgeons. San Diego, CA, US.
2009. "Clinical Results with Replicating Adenovirus, a DNA Virus". Conference. 77th Annual Meeting of the American Association of Neurological Surgeons, Section on Tumor II Session. San Diego, CA, US.
2009. "Update on Tumors for the General Neurosurgeon". Invited. American Association of Neurological Surgeons. San Diego, CA, US.
2009. "Management of Metastatic Disease". Conference. 77th Annual Meeting of the American Association of Neurological Surgeons. San Diego, CA, US.
2009. "Surgical Considerations". Invited. Brain Metastases in Breast Cancer Workshop, RTOG Cooperative Group and The Komen Foundation. Arlington, VA, US.
2008. "Neuro-Oncology and Radiosurgery". Invited. Congress of Neurological Surgeons Annual Meeting, The Community of Neurosurgery: Evidence as a Source of Knowledge Session. Orlando, FL, US.
2008. "Factors Influencing the Risk of Local Recurrence Following Resection of a Single Brain Metastasis". Conference. Congress of Neurological Surgeons Annual Meeting. Orlando, FL, US.
2008. "Surgical Resection of Tumors: Complications and Their Avoidance". Conference. Congress of Neurological Surgeons Annual Meeting, Error and Complications and Their Avoidance Seminar. Orlando, FL, US.
2008. "Cases and Coffee with the Experts: Tumors". Invited. Congress of Neurological Surgeons Annual Meeting. Orlando, FL, US.
2008. "Insula Tumors Resection". Invited. Congress of Neurological Surgeons Annual Meeting, Digital Masters Video Symposium. Orlando, FL, US.
2008. "Bone Marrow-Derived MSCs as Delivery Vehicles for Oncolytic Adenovirus Delta-24-RGD in the Treatment of Malignant Glioma". Conference. American Academy of Neurological Surgery Annual Meeting. Phoenix, AZ, US.
2008. "Gene/Oncolytic Therapy". Invited. First Joint Symposium on Neuro-Oncology and Neurosurgery. San Juan, PR, US.
2008. "Advances in Surgery". Invited. First Joint Symposium in Neuro-Oncology and Neurosurgery. San Juan, PR, US.
2008. "Tumor Derived MSCs in Human Gliomas: Isolation and Biological Properties". Conference. 42nd Annual Meeting of the American Society of Clinical Oncology (ASCO). Chicago, IL, US.
2008. "Glioblastoma Stem Cells Mediate Immune Suppression That Can Be Inhibited with Jak2/Stat3 Blockade". Conference. 42nd Annual Meeting of the American Society of Clinical Oncology (ASCO). Chicago, IL, US.
2008. "Conventional Surgery versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastases: A Prospective Study with Both Randomized and Nonrandomized Arms". Conference. American Association of Neurological Surgeons Annual Meeting, Plenary Session. Chicago, IL, US.
2008. "Cerebral Tumors and Other Lesions". Invited. American Association of Neurological Surgeons Weekend Update: Interactive Review of Clinical Neurosurgery by Case Management. Houston, TX, US.
2007. "Tumors: Interactive Case Discussions". Invited. Congress of Neurological Surgeons 57th Annual Meeting. San Diego, CA, US.
2007. "Error and Complications and Their Avoidance". Invited. Congress of Neurological Surgeons 57th Annual Meeting, Luncheon Seminar. San Diego, CA, US.
2007. "Brain Tumor Update". Invited. Congress of Neurological Surgeons 57th Annual Meeting, Practical Course. San Diego, CA, US.
2007. "A Subset of Fast Proliferating Neural Precursors Suppress Gliomas". Invited. 75th Annual American Association of Neurological Surgeons Meeting. Washington, DC, US.
2006. "Human Bone Marrow-Derived Mesenchymal Stem Cells as Delivery Vehicles for Glioma Therapy". Conference. American Academy of Neurological Surgery Annual Meeting. Greensboro, GA, US.
2006. "Human Bone Marrow-Derived Mesenchymal Stem Cells as Delivery Vehicles for Glioma Tumors". Invited. 2006 International Brain Tumor Research and Therapy Meeting (Asilomar). Napa Valley, CA, US.
2006. "Treatment of Traumatic Brain Injury in Rats with Combination Therapy of Marrow Stromal Cells and Atrovastatin". Invited. 2006 American Association of Neurological Surgeons Annual Meeting, Discussant for Scientific Session VI. San Francisco, CA, US.
2006. "Results of a Phase I Study: Convection-Enhanced Delivery of Cintredekin Besudotox (IL13-PE38QQR) Followed by Radiation Therapy Without and With Temozolomide in Newly Diagnosed Malignant Glioma Patients". Conference. American Association of Neurological Surgeons Meeting, CNS Section on Tumors I, Oral Abstract Presentation, April 22. San Francisco, CA, US.
2005. "Navigating the Possibilities, The Future of Brain Tumor Research". Invited. Brain Tumor Awareness Day presented by the Brain Tumor Foundation. New York, NY, US.
2005. "Management of Solitary Brain Metastasis: Should Focal Radiation Therapy or Surgery be the Primary Treatment". Invited. Oncology World Congress 2005. New York, NY, US.
2005. "Insular Tumor Resection". Invited. 55th Annual Meeting of the Congress of Neurological Surgeons Digital Masters Video Symposium. Boston, MA, US.
2005. "Update on Brain Metastases". Invited. 55th Annual Meeting of the Congress of Neurological Surgeons, Practical Update on Brain Tumors. Boston, MA, US.
2005. "Update on Stem Cell Applications". Invited. American College of Surgeons 91st Annual Clinical Congress. San Francisco, CA, US.
2004. "Inducible Anti-Excitotoxic Adenoviral Gene Therapy Improves Survival in a Nude Mouse Intracranial Human Glioma Model". Invited. American Association of Neurological Surgeons 72nd Annual Meeting. Orlando, FL, US.
2004. "Bone Marrow-Derived Stem Cells in the Treatment of Human Gliomas". Conference. American Association of Neurological Surgeons 72nd Annual Meeting, Plenary Session I, Peer Reviewed Oral Abstract Presentation. May 3. *Won Best Abstract. Orlando, FL, US.
2004. "Delta-24-RGD". Conference. NIH Recombinant Agent Committee (RAC) Review Meeting. Bethesda, MD, US.
2004. "Bone Marrow Stem Cells for Glioma Treatment". Invited. The Cleveland Clinic Foundation Neuro-Oncology 2004: Current Concepts CME Course. Orlando, FL, US.
2003. "Brain Metastases: A Neurosurgeon's Perspective". Invited. Society for Neuro-Oncology Eighth Annual Meeting, Meet the Expert Breakfast Session #3: Management of Metastasis to the CNS. Keystone, CO, US.
2003. "Early Phase Clinical Trial Designs: Role of Molecular Endpoints". Invited. Society for Neuro-Oncology Eighth Annual Meeting, Controversies in Neuro-Oncology #3: What Makes a Good Clinical Trial. Keystone, CO, US.
2003. "Catheter Placement". Conference. Investigator's Meeting, NeoPharm's PRECISE Trial (IL13PEI-301). Denver, CO, US.
2003. "Insular Tumor Resection". Invited. Congress of Neurological Surgeons 53rd Annual Meeting Video Kiosk (Technique Video), October 18. Denver, CO, US.
2003. "Website Updates". Conference. AANS/CNS Joint Section on Tumors Executive Council Meeting. San Diego, CA, US.
2003. "Malignant Brain Tumors: State-of-the-Art Treatment". Invited. American Association of Neurological Surgeons Annual Meeting, Breakfast Seminar. San Diego, CA, US.
2003. "Gene Therapy". Invited. North American Skull Base Society 14th Annual Meeting, Clinical Applications of Molecular Biology for Skull Base Tumors Seminar. Memphis, TN, US.
2002. "Management of Malignant Brain Tumors: A Neurosurgeon's Perspective". Invited. Advances in Neurology and Neurosurgery Program, Inova Fairfax Hospital Department of Surgery. Falls Church, VA, US.
2002. "Radiosurgery for Brainstem Metastasis: Experience at M. D. Anderson Cancer Center with 27 Patients". Conference. Congress of Neurological Surgeons 52nd Annual Meeting, Peer Reviewed Oral Abstract Presentation. Philadelphia, PA, US.
2002. "Viral Gene Therapy for Brain Tumors - Adenovirus". Invited. American Association of Neurological Surgeons and Congress of Neurological Surgeons Section on Tumors 5th Biennial Tumor Satellite Symposium. Chicago, IL, US.
2001. "Molecular Neurosurgery of Brain Tumors: Exploiting Tumor Suppressor Genes". Invited. Korean Brain Tumor Society 2001 Annual Meeting - Prospects of Brain Tumor Management in the 21st Century. Seoul.
2000. "Preliminary Results of a Phase I Clinical Trial of Adenovirus-Mediated p53 Gene Therapy for Recurrent Glioma: Biological Studies". Conference. Society for Neuro-Oncology Fifth Annual Meeting, Peer Reviewed Oral Abstract Presentation. Chicago, IL, US.
2000. "Preliminary Results of a Phase I Clinical Trial of Adenovirus-mediated p53 Gene Therapy for Recurrent Gliomas: Biological Studies". Conference. American Society of Clinical Oncology 36th Annual Meeting, Peer Reviewed Oral Abstract Presentation. New Orleans, LA, US.
2000. "Phase I Clinical Trial of Adenovirus-Mediated p53 Gene Therapy: Preliminary Results of Biological Studies". Conference. American Association of Neurological Surgeons and Congress of Neurological Surgeons Section on Tumors Fourth Biennial Satellite Symposium, Peer Reviewed Oral Abstract Presentation. San Francisco, CA, US.
1998. "Adenovirus-mediated p53 gene transfer combined with radiation or chemotherapy against human gliomas". Conference. American Association of Neurological Surgeons Section on Tumors and Congress of Neurological Surgeons - Third Biennial Brain Tumor Satellite Symposium, Peer Reviewed Oral Abstract Presentation. Philadelphia, PA, US.
1997. "Adenovirus-Mediated Delivery of the p53 Gene Sensitizes Human Gliomas to 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU)". Conference. Society for Neuro-Oncology 2nd Annual Meeting, Peer Reviewed Oral Abstract Presentation. Charlottesville, VA, US.
1997. "Adenovirus-Mediated Delivery of the p53 Gene Sensitizes Human Gliomas to 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU)". Conference. Congress of Neurological Surgeons Annual Meeting, Peer Reviewed Oral Abstract Presentation. New Orleans, LA, US.
1997. "Brain Tumor Research Update". Invited. The Jerry Cantwell Benefit and Fundraiser. New York, NY, US.

International Presentations

2026. "Biological Therapies for brain tumors". Invited. University College Cork Cancer Seminar Series- webinar. Cork, IE.
2025. Neurosurgery in brain metastasis/ Microvascular proliferation in Glioblastoma. Invited. IX Neuro-Oncology Conference 2025: Brain Metastatic Disease – Current Challenges. Santiago, CL.
2025. Biological Therapies for Malignant Brain Tumors. Conference. 2025 Annual Meeting of Taiwan Neurosurgical Society. Taichung, TW.
2025. "Phase I Trial of Mesenchymal Stem Cells Carrying Delta-24-RGD Given Intraarterially in Recurrent Glioma: Initial Report". Invited. American Academy of Neurological Surgeons Annual Meeting 2025. Athens, GR.
2025. "Phase I Trial of Mesenchymal Stem Cells Carrying Delta-24-RGD given Intraarterially in Recurrent Glioma: Initial Report". Conference. American Academy of Neurological Surgery Annual Meeting 2025. Athens, GR.
2025. "Conventional Surgical Resection Versus Stereotactic Radiosurgery for 1-3 cm Single Brain Metastases". Poster. SNO/ASCO CNS Metastases Conference 2025. Baltimore, US.
2025. "Phase I Trial of Mesenchymal Stem Cells Carrying Delta-24-RGD given Intraarterially in Recurrent Glioma: Initial Report". Conference. 24th International Conference on Brain Tumor Research and Therapy. Hokkaido, JP.
2025. "Phase I Trial of Mesenchymal Stem Cells Carrying Delta-24-RGD given Intraarterially in Recurrent Glioma: Initial Report". Invited. Society of University Neurosurgeons Meeting. San Juan, PR.
2025. "Biological therapies for the treatment of brain tumors". Invited. 45th Annual Meeting of the Japanese Congress of Neurological Surgeons. Tokyo, JP.
2024. "Delta-24-RGD Adenoviral Therapy: From Oncolysis to Immunotherapy and Delivery". Invited. The Society of University Neurosurgeons. Adelaide, AU.
2024. "Surgical Resection versus Stereotactic Radiosurgery for 1-3 cm Single Brain Metastases". Invited. The Society of University Neurosurgeons. Adelaide, AU.
2024. "Challenges of insular gliomas". Invited. State of Art in Neuro-Oncology. São Paulo, BR.
2024. "Oncolytic viruses for treatment of gliomas". Invited. State of Art in Neuro-Oncology. São Paulo, BR.
2024. "Modern concepts of surgery for brain metastasis". Invited. State of Art in Neuro-Oncology. São Paulo, BR.
2023. "Reoperation of Malignant Glioma: Indications". Invited. VIII Course of Neuro Oncology: Clinica Alemana de Santiago & MD Anderson Cancer Center. Santiago, CL.
2023. "Future Biological Therapies for Gliomas". Invited. VIII Course of Neuro Oncology: Clinica Alemana de Santiago & MD Anderson Cancer Center. Santiago, CL.
2023. "Advanced Neurosurgical Techniques: Balancing Technology and Anatomy". Invited. VIII Course of Neuro Oncology: Clinica Alemana de Santiago & MD Anderson Cancer Center. Santiago, CL.
2023. "Cellular and functional remodeling of human cerebral organoids by glioblastoma stem-like cells". Conference. Society for Neuro-Oncology. Vancouver, CA.
2023. "Systemic immune correlates associated with long-term survival after Therapeutic Adenovirus (DNX2401) plus Interferon gamma for Recurrent Glioblastoma Effect Trial (TARGET): a randomized phase 1 trial.". Invited. Society for Neuro-Oncology. Vancouver, CA.
2023. "Differential effects of neurotransmitters on the growth of glioblastoma subtypes". Conference. Society for Neuro-Oncology. Vancouver, CA.
2023. "Evolution of Biological Therapies for Glioblastoma". Invited. Jeju Tour, 41st Annual Spring Meeting of the Korean Neurosurgical Society 2023. Ceju.
2023. "Engineered Exosomes Carrying Polycistronic MicroRNA for the Treatment of Glioblastoma". Invited. 23rd ICBTRT (International Conference on Brain Tumor Research and Therapy) 2023. Kiawah Island, US.
2021. "Neurosurgical Management of Low Grade Gliomas: Insular Tumors". Invited. 26th Annual Meeting of the Japanese Congress for Brain Tumor Surgery. Virtual, JP.
2021. "Developing a Brain Metastasis Clinic". Invited. Clinica Alemana VI Neuro Oncology Online Course: A Multidisciplinary Approach. Virtual, CL.
2021. "Establishing Neurooncological Centres and Foster New Therapeutic Strategies". Invited. 72nd Annual Meeting German Society of Neurosurgery (DGNC). Virtual, DE.
2021. "Sulcus-guided Resection: Insular Tumors". Invited. Clinica Alemana VI Neuro Oncology Online Course: A Multidisciplinary Approach. Virtual, CL.
2021. "En Bloc Sulcus-Guided Resection of Gliomas". Invited. Gleneagles Global Hospital Neuro-Oncology Monthly Webinar Virtual Talk. Virtual, IN.
2020. "Does Extent of Resection Impact Survival in GBMs". Invited. Annual Conference on Evidence Based Management of Cancers in India. Mumbai, IN.
2020. "Immunotherapy in Gliomas: Oncolytic Viruses". Invited. Annual Conference on Evidence Based Management of Cancers in India. Mumbai, IN.
2019. "Intraoperative Techniques to Enhance Safety of Resection of Intrinsic Tumors: Insular Tumors and Low Grade Gliomas". Invited. World Federation of Neurosurgical Societies Special World Congress, Neuro-Oncology Pre Congress Meeting. Beijing, CN.
2019. "MSC Delivery of Oncolytic Adenovirus Delta-24-RGD Following Surgical Resection of Glioblastoma". Conference. 81st Annual Meeting of the American Academy of Neurological Surgery. Rome, IT.
2019. "Awake Surgery and IntraOperative Mapping”. Invited. Society for Neuro-Oncology Sub-Saharan Africa 2019 Meeting, Cape Town, Africa. Cape Town, ZA.
2019. "Brain Tumors and Endovascular Treatments with Stem Cells". Conference. The Society of University Neurosurgeons Annual Meeting. Dubrovnik, HR.
2019. "Evolution of Neuro-Oncology Practice at MD Anderson Cancer Center". Invited. Masterclass in Neurosurgical Oncology Course, Neuro-Oncology Symposium Session I. Mumbai, IN.
2019. "Neurosurgeon Scientist: A Vital Cog in Advancing Neuro-Oncology Research and Therapy". Invited. Masterclass in Neurosurgical Oncology Course. Mumbai, IN.
2018. "Preclinical in vitro and in vivo studies of endovascular intra-arterial injection of mesenchymal stem cells loaded with oncolytic virus Delta-24-RGD". Invited. 22nd International Conference on Brain Tumor Research and Therapy. Bergen, NO.
2018. "Biological therapies for gliomas: oncolytic viruses and bone marrow-derived mesenchymal stem cells". Invited. Armed Oncolytic Immunotherapies Summit. Frankfurt, DE.
2017. "Experimental Therapeutics: Biological Therapies". Invited. 2017 Current Trends in Malignant Gliomas: New Horizons in the Treatment of Brain Tumors. Xiamen, CN.
2017. "Surgical Treatment of Gliomas". Invited. 2017 Current Trends in Malignant Gliomas: New Horizons in the Treatment of Brain Tumors. Xiamen, CN.
2017. "Exploiting Biological Therapies for Treating Gliomas". Invited. 6th International Symposium on Translational Oncology & Clinical Research, Barretos Cancer Hospital. Barretos, BR.
2016. "Approach to Insular and Low-Grade Tumors". Invited. 59th Chilean Congress of Neurosurgery, Joint Meeting of the World Federation of Neurosurgical Society Course. La Serena, CL.
2016. "Surgical Resection of Insular Tumors: A Single Surgeon Perspective". Invited. 56th Annual Meeting of the Korean Neurosurgical Society. Seoul.
2016. "Surgery of Insular Tumors: Morbidity and Mortality". Invited. 31st CBN Kunio Suzuki Brazilllian Congress of Neurosurgery. Asa Sul, BR.
2016. "Surgical Resection of Insular Tumors: Techniques". Invited. 31st CBN Kunio Suzuki Brazillian Congress of Neurosurgery. Asa Sul, BR.
2016. "Novel Biological Treatments of Gliomas". Invited. 31st CBN Kunio Suzuki Brazillian Congress of Neurosurgery. Asa Sul, BR.
2016. "Exploiting exosomes from hBMSCs to deliver miRNAs". Invited. 21st International Conference on Brain Tumor Research & Therapy. Okinawa, JP.
2016. "Biological Therapies for Brain Tumors". Invited. Keynote Speaker, 13th Asian Pacific Multidisciplinary Meeting for Nervous System Diseases. Shatin, HK.
2016. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Invited. 13th Asian Pacific Multidisciplinary Meeting for Nervous System Diseases. Shatin, HK.
2015. "Exploiting Exosomes from hMSCs to Deliver Therapeutic miRNAs to Gliomas". Invited. The American Academy of Neurological Surgery 77th Annual Meeting, Joint Meeting with the German Society for Neurosurgery & German Academy of Neurological Surgery. Heidelberg, DE.
2015. "Surgery for Low Grade Gliomas". Invited. World Federation of Neurosurgical Societies Neuro-Oncology Course, Asian Society for Neuro-Oncology & Academy of Filipino Neurosurgeons Annual Meeting. Manila, PH.
2015. "Update on Oncolytic Viral Therapy: From Oncolysis to Viro-Immunotherapy". Invited. Advances in Brain Therapeutics Session, 15th Interim Meeting of the World Federation of Neurosurgical Societies. Rome, IT.
2015. "Oncolytic Viruses as Anti-glioma Agents". Invited. World Federation of Neurosurgical Societies Neuro-Oncology Course, Asia Society for Neuro-Oncology & Academy of Filipino Neurosurgeons Annual Meeting. Manila, PH.
2015. "Technical Aids to Enhance Glioma Resections". Invited. World Federation of Neurosurgical Societies Neuro-oncology Course, Asian Society for Neuro-Oncology & Academy of Filipino Neurosurgeons Annual Meeting. Manila, PH.
2015. "Delta-24-RGD for Glioblastoma: Evolution of Oncolytic Virotherapy to Viro-Immunotherapy". Invited. Young Investigator Workshop, MD Anderson Cancer Center Global Academic Program, The Institute of Cancer Research, The Radium Hospital. Oslow, NO.
2015. "Surgery of Insula Tumors". Invited. International Meeting Updates in Neuro-Oncology. Cortona, IT.
2015. "Current Clinical Trials Relating to Neurosurgical Intervention for Gliomas". Invited. Chinese Society of Neuro-Oncology, Joint Meeting with the Society for Neuro-Oncology. Guangzhou, CN.
2015. "Advances on Neurosurgery for Glioma Treatment". Invited. Chinese Society of Neuro-Oncology, Joint Meeting with the Society for Neuro-Oncology. Guangzhou, CN.
2014. "Exploiting viruses and stem cells for brain tumor treatment". Invited. 73rd Annual Japan Neurosurgical Society Meeting. Tokyo, JP.
2014. "Management of brain metastasis including a phase III trial comparing surgery to radiosurgery". Invited. Benavides Cancer Institute, University of Santo Tomas Joint Meeting with Philippine Breast Cancer Society. Manila, PH.
2014. "Surgical Treatment of Low Grade Gliomas". Invited. Neuro-Oncology Symposium: High & Low Grade Gliomas. Buenos Aires, AR.
2014. "New Paradigms in the Treatment of High Grade Gliomas". Invited. Neuro-Oncology Symposium: High & Low Grade Gliomas. Buenos Aires, AR.
2014. "Insular Gliomas". Invited. Neuro-Oncology Symposium: High & Low Grade Gliomas. Buenos Aires, AR.
2014. "Surgical Treatment of Brain Metastases". Invited. Neuro-Oncology Symposium: High & Low Grade Gliomas. Buenos Aires, AR.
2013. "Controversies in the surgical approach for brain metastasis". Invited. European Association of Neurosurgical Societies (EANS) Joint Annual Meeting AANS/CNS Section on Tumors Annual International Neuro-Oncology Updates. Tel Aviv, IL.
2013. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Invited. 15th Annual Arthur and Sonia Labatt Brain Tumour Research Centre Scientific Lectureship. Toronto, CA.
2012. "Exosomes from glioma-associated MSCs modulate the proliferation of glioma stem cells". Invited. 19th International Brain Tumor Research and Therapy Conference (Asilomar), Platform Presentation. Niagara Falls, CA.
2012. "Insular gliomas". Invited. White Matter Dissection Technique and DTI Fiber Tracking Course, 7th Central European Neurosurgical Society Meeting. Prague, CZ.
2011. "Surgical resection of insular gliomas: a personal perspective". Invited. 14th European Congress of Neurosurgery, European Association of Neurological Surgeons. Rome, IT.
2010. "MSCs: Delivery Vehicle or Therapeutic Target". Invited. Japan Neurosurgical Society Annual Meeting. Fukuoka, JP.
2010. Oncolytic adenovirus Delta-24-RGD: from bench to bedside and back. Invited. Guangdong International Neurosurgery Summit. Guangdong, CN.
2009. "Oncolytic Adenovirus Delta-24-RGD: From Bench to Bedside". Invited. 16th Annual Meeting of the Taiwan Neurosurgical Society. Taipei, TW.
2009. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Invited. 16th Annual Meeting of the Taiwan Neurosurgical Society. Taipei, TW.
2009. "Role of MSCs in the Biology of Gliomas". Invited. 4th Meeting on Trends in CNS Malignancies, EANO/EORTC. Budapest, HU.
2008. "Recent Advances in the Management of Infiltrating Low-Grade Gliomas: Molecular Characteristics, Prognostic Factors and Treatment Options". Invited. University of Istanbul, Prof. Feyyaz Berkay Neurosurgery Days, Limbic and Paralimbic Tumors Workshop. Istanbul, TR.
2008. "Current Management of Malignant Gliomas - An Overview of Promising Clinical Trials in MDACC". Invited. University of Istanbul, Prof. Feyyaz Berkay Neurosurgery Days, Limbic and Paralimbic Tumors Workshop. Istanbul, TR.
2008. "Surgery of the Intrinsic Insular Tumors". Invited. University of Istanbul, Prof. Feyyaz Berkay Neurosurgery Days, Limbic and Paralimbic Tumors Workshop. Istanbul, TR.
2008. "Surgical Resection of Insular Tumors" (Video Session). Invited. University of Istanbul, Prof. Feyyaz Berkay Neurosurgery Days, Limbic and Paralimbic Tumor Workshop. Istanbul, TR.
2008. "Tumor Derived MSCs in Human Gliomas: Isolation and Biological Properties". Invited. 17th International Conference on Brain Tumor Research and Therapy. Hakodate, JP.
2007. "Resection of Insular Tumors" (via satellite). Invited. International Neurosurgery Update, Uijeongbu St. Mary's Hospital. Uijeongbu.
2007. "Biological Therapies for Brain Tumors" (via satellite). Invited. Uijeongbu St. Mary's Hospital, International Neurosurgery Update. Uijeongbu.
2006. "Management of Low-Grade Lesions of the Brain - Evidence-Based Approach". Invited. 26th Annual Brazilian Congress of Neurosurgery. Florianopolis, BR.
2006. "Novel Biological Treatment for Malignant Gliomas". Invited. 26th Annual Brazilian Congress of Neurosurgery. Florianopolis, BR.
2006. "Resection of Insular Gliomas - Indication, Techniques and Results". Invited. 26th Annual Brazilian Congress of Neurosurgery. Florianopolis, BR.
2004. "Mesenchymal Stem Cells". Invited. Society of Neuro-Oncology Annual Meeting, Meet the Experts Session. Toronto, CA.
2004. "A Neurosurgeon's View of the Indications for Surgery vs. Radiosurgery". Invited. Society of Neuro-Oncology Annual Meeting, Update and Controversies in the Management of 1-3 Brain Metastases Session. Toronto, CA.
2004. "Molecular Neurosurgery for Malignant Gliomas". Invited. 2nd American-Japanese Neurosurgical Friendship Symposium. Tokyo, JP.
2004. "Bone-Marrow Derived Stem Cells in the Treatment of Brain Tumors". Invited. 63rd Annual Meeting of the Japanese Neurosurgical Society. Tokyo, JP.
2004. "Surgical Resection of Intrinsic Insular Tumors: Complication Avoidance". Invited. 13th World Congress of Neurological Surgery, Breakfast Seminar: How I Do It: Sylvian Fisure Glioma Surgery. Marrakech, MA.
2004. Longitudinal stereotactic injections of oncolytic immunoactivating rQNestin34.5v.2 (CAN 3110) with concomitant biopsies for “ omic ” analyses in recurrent glioblastoma (GBM). Conference. Annual Meeting of the American Society of Clinical Oncology, US.
2002. "Recent Therapeutic Advances I: Gene & Oncolytic Viral Therapy & Surgery vs Radiosurgery: A Rational Approach". Invited. IV International Neuro-Oncology Symposium. Sao Paulo, BR.
2001. "Brain Metastases". Invited. American Association of Neurological Surgeons 70th Annual Meeting, Practical Clinic: Update on Tumors for the General Neurosurgeon. Toronto, CA.
2001. "Phase I Clinical Trial of Adenovirus-Mediated p53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results". Conference. American Association of Neurological Surgeons 70th Annual Meeting, Peer Reviewed Oral Abstract Presentation. Toronto, CA.
1998. "Primary Brain Tumors". Invited. XVII UICC International Cancer Congress. Rio de Janeiro, BR.
1998. "Brain Metastasis: Emerging Management Strategies". Invited. XVII UICC International Cancer Congress. Rio de Janeiro, BR.

Formal Peers

2025. "Biological Therapies for Brain Tumors". Cold Spring Harbor, NY, US.
2024. "Delta-24-RGD Adenoviral Therapy: From Oncolysis to Immunotherapy and Delivery". Invited. Cold Spring Harbor, NY, US.
2024. "Biological Therapies for Brain Tumors". Visiting. Austin, TX, US.
2023. "Biological Therapies for the Treatment of Glioblastoma". Visiting. Genova, IT.
2023. UCLA SPORE in Brain Cancer-External Advisory Board Meeting. Visiting. Los Angeles, CA, US.
2022. "Evolution of Biological Therapies for Glioblastoma". Invited. Dallas, TX, US.
2022. “Evolution of Biological Therapies for Glioblastoma". Visiting. New York, NY, US.
2022. “Evolution of Biological Therapies for Glioblastoma". Visiting. New York City, NY, US.
2022. “Evolution of Biological Therapies for Glioblastoma”. Visiting. Houston, TX, US.
2022. "Biological Therapies for Gliomas: Viral and Cell-Based Therapies". Visiting. Virtual, US.
2021. "Biological Therapies for Brain Tumors: Oncolytic Viruses & Bone Marrow Stem Cells’". Visiting. New York, NY, US.
2021. "Biological Therapies for Gliomas: Viruses and Stem Cells". Visiting. Virtual, US.
2021. "Biological Therapies in the Treatment of Gliomas". Visiting. Virtual, US.
2021. "Biological Therapies for Brain Tumors: Oncolytic Viruses & Bone Marrow Stem Cells". Visiting. Virtual, US.
2021. "Biological Therapies for Brain Tumors". Visiting. Virtual, US.
2020. "Biological Therapies for Brain Tumors: Viruses and Stem Cells". Visiting. Virtual, US.
2020. "Biological Therapies for Gliomas: Viruses & Stem Cells". Visiting. Washington, DC, US.
2019. “Biological Therapies for Malignant Gliomas”. Visiting. San Francisco, CA, US.
2019. "Biological Therapies for Gliomas: Oncolytic Viruses & Bone Marrow Stem Cells". Visiting. New York, NY, US.
2019. "Biological Therapies for Gliomas: Oncolytic Viruses & Bone Marrow Stem Cells". Visiting. New Haven, CT, US.
2018. "Biological Therapies in the Treatment of Human Gliomas". Visiting. Minneapolis, MN, US.
2017. "Biological Therapies in the Treatment of Gliomas". Visiting. Baltimore, MD, US.
2017. "Clinical Trial Using MSCs to Deliver Delta-24". Invited. San Francisco, CA, US.
2016. "Exploiting Biological Therapies for Brain Tumors". Visiting. Seoul.
2016. "Exploiting Biological Agents for Brain Tumor Therapy: Oncolytic Virus Delta-24-RGD". Invited. Freemont, CA, US.
2016. "MD Anderson Brain Cancer SPORE Overview". Invited. Boston, MA, US.
2016. "Project 1: Tropism Enhanced Oncolytic Adenovirus for Treatment of Brain Tumors". Invited. Boston, MA, US.
2016. "Exploiting Biologic Therapies for Brain Tumors". Invited. Clearwater, FL, US.
2016. "Insular Tumor Resection: Pearls and Pitfalls". Visiting. Stanford, CA, US.
2016. "Exploiting Viruses and Stem Cells to Treat Brain Tumors". Visiting. Stanford, CA, US.
2015. "Exploiting Viruses and Stem Cells in Brain Tumor Therapy". Invited. Tinton Falls, NJ, US.
2015. "Exploiting Viruses and Stem Cells for Glioma Therapy". Invited. Philadelphia, PA, US.
2015. "Exploiting Viruses and Stem Cells in Brain Tumor Therapy: From Bench to Bedside and Back". Visiting. Philadelphia, PA, US.
2015. "Management of Low-Grade Gliomas with Emphasis on Insular Gliomas". Visiting. Philadelphia, PA, US.
2014. "Delta-24-RGD: Reports from the Cold War Against Gliomas". Visiting. Columbus, OH, US.
2014. "Surgical Resection of Insular Gliomas". Visiting, WI, US.
2014. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Visiting, WI, US.
2013. "Oncolytic Virus Delta-24-RGD: Clinical Trial Results and Implications for Viroimmunotherapy". Visiting. Sun Valley, ID, US.
2013. "Surgical Resection of Insular Gliomas". Visiting. Sun Valley, ID, US.
2013. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Invited. Birmingham, AL, US.
2011. "Bone Marrow Derived MSCs in the Treatment of Human Ependymomas". Invited. Tucson, AZ, US.
2011. "Microsurgical Management of Metastatic Disease". Invited. Scottsdale, AZ, US.
2011. "Mesenchymal Stem Cells in the Biology and Therapy of Gliomas". Invited. Scottsdale, AZ, US.
2011. "Mesenchymal Stem Cells and Malignant Gliomas". Visiting. Los Angeles, CA, US.
2011. "Mesenchymal Stem Cells and Human Gliomas". Invited. Houston, TX, US.
2011. "Mesenchymal stem cells in the therapy and biology of gliomas". Visiting. Rochester, MN, US.
2010. "Oncolytic adenovirus Delta-24-RGD: from bench to bedside and back". Visiting. Seoul.
2010. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Visiting. New York, NY, US.
2010. "Mesenchymal Stem Cells in the Therapy and Biology of Gliomas". Visiting. New Haven, CT, US.
2009. "Management of Low Grade Gliomas: The Example of Insula Tumors". Invited. Rochester, NY, US.
2009. "Mesenchymal stem cells in glioma therapy and biology". Visiting. Rochester, NY, US.
2008. "Conventional Surgery versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastases: A Prospective Trial with Both Randomized and Nonrandomized Arms". Invited. Houston, TX, US.
2008. "Status of the Neuro Stem Cell". Visiting. Round Top, TX, US.
2007. "Insular Tumors". Invited. Houston, TX, US.
2007. "Insular Tumor Resection and Glioma Surgery". Visiting. Peoria, IL, US.
2007. "Viral and Cellular Therapy for Brain Tumors". Visiting. Peoria, IL, US.
2005. "Stem Cells and Brain Tumor Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Human Gliomas". Invited. Houston, TX, US.
2004. "Gene, Viral and Cellular Strategies for the Treatment of Human Gliomas". Visiting. New York, NY, US.
2004. "Molecular & Cellular Therapies for Brain Tumors". Invited. Houston, TX, US.
2003. "Gene, Viral and Cellular Approaches to Brain Tumor Therapy". Visiting. New York, NY, US.
2003. "Malignant Brain Tumors: Therapy in the Molecular Neurosurgical Era". Visiting. New York, NY, US.
2003. "Stem Cell-Based Glioma Therapy". Invited. Houston, TX, US.
2003. "Advances in Brain Tumor Management". Visiting. Augusta, GA, US.
2003. "Molecular Therapeutic Approaches to Brain Tumors". Visiting. Augusta, GA, US.
2001. "Brain Tumor Therapy: Exploiting Tumor Suppressor Genes". Visiting. Bethesda, MD, US.
2001. "Tumor Suppressor Targeted Therapy". Invited. Cleveland, OH, US.
2000. "p53 Gene Therapy - Preclinical and Clinical Studies". Invited. San Francisco, CA, US.
1998. "p53 Gene Therapy". Visiting. New York, NY, US.
1998. "Surgical Resectability of Brain Tumors: Recent Advances". Invited. Houston, TX, US.

Less

Grant & Contract Support

Date:	2025 - 2028
Title:	Immune competent, adenoviral-permissive hamster models of GBM to evaluate the mechanisms and efficacy of oncolytic adenoviral therapy
Funding Source:	Department of Defense
Role:	PI
ID:	FP00024769

Date:	2025 - 2030
Title:	Human Mesenchymal Stem Cells Loaded with a Tumor Selective Oncolytic Adenovirus Administered via Intra-Arterial Injection in Patients with Recurrent High Grade Gliomas
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	PA-20-183

Date:	2025 - 2029
Title:	Human Mesenchymal Stem Cells Loaded with a Tumor Selective Oncolytic Adenovirus Administered via Intra-Arterial Injection in Patients with Recurrent High Grade Gliomas
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-PI
ID:	RP250146

Date:	2023 - 2028
Title:	Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	1 R25 CA265800-01A1

Date:	2022 - 2027
Title:	Image Guided Cancer Therapy Training Program
Funding Source:	NIH/NCI
Role:	Preceptor
ID:	1 T32CA261856-01A1

Date:	2022 - 2027
Title:	A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1R01 CA257788-01A1

Date:	2022 - 2026
Title:	Analyzing Adhesion and Signaling Functions for PTPN12 in Invasive Glioma Cells
Funding Source:	NIH/NCI
Role:	Other Significant Contributor
ID:	NS122052

Date:	2021 - 2026
Title:	Systematic Dissection of Function and Mechanism of Long Non-Coding RNAs in Glioblastoma
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	R01NS117668-01A1

Date:	2021 - 2026
Title:	Glioma Therapy with Oncolytic Adenoviruses and Immunometabolic Adjuvants
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01CA256006

Date:	2020 - 2025
Title:	New Therapeutic Approaches for Stratified High-REST GBM Subtype
Funding Source:	NIH/NINDS
Role:	Co-I
ID:	R01 NS119162

Date:	2020 - 2025
Title:	Determining the Optimal Ion and Fractionation Scheme for the Treatment of GBM in a Comprehensive Human Organoid Model
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01 CA256848-01

Date:	2020 - 2023
Title:	Counteracting Space Radiation by Targeting Neurogenesis in a Human Brain Organoid Model
Funding Source:	National Aeronautics and Space Administration (Subcontract with Baylor College of Medicine)
Role:	Co-I
ID:	NNX16AO69A

Date:	2020 - 2025
Title:	A Novel Adenoviral-Permissive, Immunocompetent Hamster Model to Evaluate Oncolytic Adenoviral Therapy for Glioblastoma
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA247970

Date:	2019 - 2024
Title:	Combating Breast Cancer Brain Metastasis by Blocking the Two-Pronged Driver Kinase Function of CDK5
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01 CA231149-01A1

Date:	2017 - 2022
Title:	MSC-Derived Exosomes and microRNA in Glioma Therapy
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA214749-01A1

Date:	2014 - 2024
Title:	Glioblastoma Moonshot: Longitudinal CSF and Blood Monitoring of Genomic Alterations in Patients & Phase I Clinical Trial of Delta-24-RGD Using BM-hMSCs
Funding Source:	The University of Texas MD Anderson Cancer Center
Role:	Co-PI

Date:	2014 - 2015
Title:	Defeat GBM Collaboration Agreement - Project 2 Drug Development
Funding Source:	National Brain Tumor Society
Role:	Co-PI

Date:	2013 - 2019
Title:	SPORE in Brain Cancer Core A: Administrative Core
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	5P50 CA127001-10

Date:	2013 - 2024
Title:	SPORE in Brain Cancer
Funding Source:	NIH/NCI
Role:	Principal Investigator, SPORE Director, Project 1 Co-Leader, CEP, DRP, Administrative Core, Pathology and Biorepository Core Directors
ID:	2P50 CA127001-11A1

Date:	2013 - 2018
Title:	SPORE in Brain Cancer Development Research Program
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	P50 CA127001-06

Date:	2013 - 2019
Title:	SPORE in Brain Cancer, Project 1: Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain Tumors
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	5P50 CA127001-10

Date:	2013 - 2019
Title:	SPORE in Brain Cancer
Funding Source:	NIH/NCI
Role:	PI
ID:	5P50 CA127001-10

Date:	2013 - 2018
Title:	SPORE in Brain Cancer Career Development Program
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	P50 CA127001-06

Date:	2013 - 2024
Title:	Cancer Center Support Grant (CCSG) Brain Cancer Program
Funding Source:	NIH/NCI
Role:	Co-Program Leader
ID:	P30 CA016672

Date:	2012 - 2013
Title:	MSCs as Natural Bio-Factories for Nanosized Exosomes Carrying STAT3 siRNA, SPORE in Brain Cancer Developmental Research Program
Funding Source:	NIH/NCI
Role:	PI
ID:	5-P50-CA127001

Date:	2011 - 2014
Title:	Bone marrow-derived mesenchymal stem cells in the treatment of human ependymomas
Funding Source:	Collaborative Ependymoma Research Network (CERN) Foundation
Role:	PI

Date:	2008 - 2012
Title:	Glioma Cancer Stem Cells and Tumor-Derived Mesenchymal Stem Cells: Role and Cross-Talk in Human Gliomas
Funding Source:	The Ben and Catherine Ivy Foundation
Role:	Co-PI

Date:	2008 - 2013
Title:	Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain Tumors
Funding Source:	NIH/NCI
Role:	Co-Leader, Project 1
ID:	1P50 CA127001-02A1

Date:	2008 - 2013
Title:	Animal Core
Funding Source:	NIH/NCI
Role:	Co-Director, Core E
ID:	1P50 CA127001-02A1

Date:	2008 - 2009
Title:	Use of Mesenchymal Stem Cells as a Therapeutic Delivery Vehicle to Prevent Tumor Progression in a Mouse Model of Human Spinal Metastasis
Funding Source:	Institutional Research Grant (IRG) The University of Texas M.D. Anderson Cancer Center
Role:	Collaborator

Date:	2008 - 2009
Title:	Targeting Glioma Cancer Stem Cells Using Bone Marrow Derived Mesenchymal Stem Cells
Funding Source:	National Brain Tumor Foundation
Role:	PI

Date:	2008 - 2008
Title:	Project 3: Regulation of Mesenchymal Transition in GBM Tumor Stem Cells
Funding Source:	MRP
Role:	Core Leader

Date:	2007 - 2009
Title:	Targeting Medulloblastoma: Studying Mesenchymal Stem Cells in the RCAS/TVA-based Animal Model
Funding Source:	Center for Targeted Therapy Disease-Specific Grant Program
Role:	Co-I

Date:	2007 - 2009
Title:	Targeting Gliomas with Biological Therapies: Mesenchymal Stem Cells to Deliver Delta-24-RGD to Gliomas
Funding Source:	Center for Targeted Therapy Disease-Specific Grant Program
Role:	PI

Date:	2007 - 2009
Title:	Image Localization for Pathologic Correlation of Delta-24-RGD
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1R21 CA126115-01

Date:	2006 - 2012
Title:	Bone Marrow Stem Cells: Novel Treatment of Human Glioma
Funding Source:	NIH/NCI
Role:	PI
ID:	5R01 CA115729-05

Date:	2006 - 2012
Title:	Efficacy and Toxicity of TRAIL Against Gliomas
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	1R01 CA114422-01A1

Date:	2005 - 2007
Title:	Human Mesenchymal Stem Cells for Delivery of Delta-24 to Gliomas
Funding Source:	Run for the Rose Fund
Role:	PI

Date:	2003 - 2009
Title:	Regulation of p53-mediated Apoptosis in Gliomas
Funding Source:	NIH/NCI
Role:	PI
ID:	1R01 CA098716-05

Date:	2002 - 2004
Title:	Development of an Implantable Brain Tumor Serial Biopsy Device
Funding Source:	Whitaker Foundation
Role:	PI

Date:	2002 - 2004
Title:	Correlative Trial of Fenretinide against Glioblastomas
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1R21 CA97767-01

Date:	2002 - 2007
Title:	Conditional Replicating Adenovirus for Glioma
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1R01 CA090879-01

Date:	2002 - 2004
Title:	Solid Organ Tissue from Adult Circulating Stem Cells
Funding Source:	The University of Texas M. D. Anderson Cancer Center Multidisciplinary Research Program
Role:	Collaborator

Date:	2002 - 2003
Title:	Adenovirus-Mediated p53 Gene Therapy for Brain Tumors: A Phase I Clinical Trial Using Convection Enhanced Delivery
Funding Source:	W. M. Keck Center for Cancer Gene Therapy Development Award
Role:	PI

Date:	2002 - 2003
Title:	Preclinical Testing of Malignant Glioma Models for Signal Transduction Inhibitors and Cytotoxic Agents
Funding Source:	Accelerate Brain Cancer Cure
Role:	Co-PI

Date:	2002 - 2003
Title:	Gene and Viral Therapy for Brain Tumors
Funding Source:	Golfers Against Cancer
Role:	PI

Date:	2001 - 2002
Title:	A Phase II Study Utilizing the GliaSite RTS for the Treatment of a Resected Solitary Brain Metastasis
Funding Source:	GliaSite
Role:	PI
ID:	NS01-172/CS01-236-1

Date:	2001 - 2002
Title:	p53 Replacement Therapy: Improving Gene Delivery
Funding Source:	The Cleveland Clinic Foundation
Role:	PI

Date:	2001 - 2002
Title:	Phase I Study to Assess the Histologic Effect and Safety of Preoperative and Postoperative Infusions of IL13-PE38QQR Cytotoxin Patients with Recurrent Resectable Supratentorial Malignant Glioma
Funding Source:	NeoPharm
Role:	PI
ID:	NS01-127/CS01-222-1

Date:	2001 - 2001
Title:	Radiosensitization by AntiRAS scFv-Expressing Adenovirus
Funding Source:	Introgen Therapeutics, Inc
Role:	PI
ID:	1R41 CA83604-01

Date:	2000 - 2001
Title:	A Selective COX-2 Inhibitor, in Combination with Radiation for the Treatment of Human Gliomas
Funding Source:	Kleberg Fund for New & Innovative Research Allocation for Institutional Research Grant
Role:	PI

Date:	2000 - 2001
Title:	Enhancing the Efficacy of p53 Gene Therapy for Human Gliomas
Funding Source:	NIH/NCI (North American Brain Tumor Consortium)
Role:	PI
ID:	5U01 CA62399-7

Date:	1998 - 1999
Title:	Adenovirus-Mediated p53 Gene Transfer Combined with Ionizing Radiation and Antineoplastic Agents Against p53-Wild-Type Human Gliomas
Funding Source:	American Association of Neurological Surgeons
Role:	PI

Selected Publications

Peer-Reviewed Articles

De, A, Forero, SA, Pirani, AM, Morales, JE, De La Fuente-Granada, M, Sebastian, S, Huse, J, Ballester, L, Weinberg, J, Lang, F, Akdemir, KC, McCarty, J. Single cell spatial profiling of the matrisome identifies region-specific adhesion and signaling networks in glioblastoma. Communications Biology 9(1), 2026. e-Pub 2026. PMID: 41366031.
Pirhoushiaran, M, Walker-Charles, K, Yao, TH, Putluri, S, Patel, N, Wang, DH, Wang, I, Arjuna, S, Dono, A, Bueno, A, Nguyen, S, Balar, AP, Huse, J, Kundu, S, Esquenazi, Y, Patel, C, Prabhu, SS, Lang, FF, Ballester, L. Exploring CSF microRNA signatures as diagnostic biomarkers in adult-type diffuse gliomas. Non-coding RNA Research 18:22-38, 2026. e-Pub 2026. PMID: 41624475.
Muir, M, Noll, KR, Patel, RP, Prinsloo, S, Michener, H, Kumar, VA, Ene, CI, Ferguson, SD, Weinberg, J, Lang, FF, Taylor, BA, Prabhu, SS. Toward data-driven surgical planning. Journal of neurosurgery 144(2):324-335, 2026. e-Pub 2026. PMID: 41135113.
Yu, K, Basu, S, Baquer, G, Ahn, R, Gantchev, J, Jindal, S, Regan, MS, Abou-Mrad, Z, Prabhu, MC, Williams, MJ, D’Souza, AD, Malinowski, S, Hopland, K, Elhanati, Y, Stopka, SA, Stortchevoi, A, Couturier, C, He, Z, Sun, JJ, Chen, Y, Espejo, A, Chow, KH, Yerrum, S, Kao, PL, Kerrigan, BP, Norberg, L, Nielsen, D, Douville, C, Sharma, P, Giantini-Larsen, AM, Hu, J, Ayoub, G, Elharouni, D, Polk, MJ, Landivar, AM, Masud, N, Ling, AL, Triggs, D, Piranlioglu, R, Ball, A, Soni, H, Solomon, IH, Vasquez, KL, Vogelzang, J, Puduvalli, VK, Huse, J, Kim, YB, Goswami, S, Lang Jr, FF, Sharma, P. Investigative needle core biopsies support multimodal deep-data generation in glioblastoma. Nature communications 16(1), 2025. e-Pub 2025. PMID: 40295505.
Morad, G, Damania, A, Melendez, B, Singh, BB, Veguilla, FJ, Soto, RA, Hoballah, YM, Sahasrabhojane, P, Wong, M, Ahmed, M, Rico, R, Lewis, KN, Wani, K, Shamsutdinova, D, Lazcano Segura, RN, Ingram, D, Goethe, E, Day, A, Flores, I, McDaniel, L, Chelvanambi, M, Johnson, S, Dimitriou, F, Gupta, P, Oberai, S, Zal, MA, Doss, P, Jamal, MA, Hayase, E, Wathoo, C, Norberg, L, Jenkins, SL, Nass, S, Gumin, J, Long, L, Yang, J, Bradley, GR, Bekal, MP, Dono, A, Pichardo-Rojas, PS, Andrewes, S, Ballester, L, Losh, JS, Liang, J, Huo, L, Nielsen, D, Parker Kerrigan, BC, Brastianos, PK, Fowlkes, NW, Chang, C, Jenq, RR, Gomez-Manzano, C, Huse, J, Davies, MA, Lazar, A, Bhat, KP, Tandon, N, Esquenazi, Y, Peterson, CB, Puduvalli, VK, Lang, FF, Johnston, CD, Bullman, S, Ajami, NJ, Ferguson, SD, Wargo, J. Microbial signals in primary and metastatic brain tumors. Nature medicine 31(11):3675-3688, 2025. e-Pub 2025. PMID: 41238915.
Muir, M, Noll, KR, Prinsloo, S, Michener, H, Traylor, JI, Kumar, VA, Ene, CI, Ferguson, SD, Liu, HL, Weinberg, J, Lang, F, Taylor, BA, Forkel, SJ, Prabhu, SS. Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection. Human Brain Mapping 46(15), 2025. e-Pub 2025. PMID: 41099461.
Ling AL, Gantchev J, Prabhu MC, Basu S, Ahn R, D'Souza A, Masud N, Ball A, Nikas O, Villa GR, Regan MS, Baquer G, Ayoub G, Whittaker CA, Abou-Mrad Z, Santos A, Couturier CP, Elharouni D, Vogelzang J, Yu KKH, Chen H, He Z, Jiang W, Lucas CH, Sax HE, Lang FF, Puduvalli VK, Tabar V, W Brennan C, Boire A, Holdhoff M, Bettegowda C, Cima M, Solomon IH, Yuan Y, Tak PP, Sharma P, White FM, Ligon KL, Agar NYR, Reardon DA, Oliveira G, Chiocca EA. Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses. Sci Transl Med 17(819):eadv2881, 2025. e-Pub 2025. PMID: 41061048.
Perez-Chadid, DA, Dange, RM, Eyre, HA, Fieggen, G, Vaughan, KA, Sheth, SA, Abdullah, JM, Shehu, BB, Donoho, D, Browd, SR, Ibanez, A, Gupta, S, Lang, FF, Nanda, A, Rosseau, G. The Neurosurgeon's Role in the Brain Economy. World Neurosurgery 202, 2025. e-Pub 2025. PMID: 40774587.
Ramirez-Ferrer E, Zuluaga-Garcia JP, Weinberg JS, Ene CI, Raza SM, Lang FF, Kan PT, Chen SR, Young CC. Chronic subdural hematoma treatment in oncological patients: middle meningeal artery embolization versus surgical drainage. Neurosurg Focus 59(4):E14, 2025. e-Pub 2025. PMID: 41032892.
Dasgupta P, Lin H, Kumar G, Soomro Z, Ayala MM, Parra ER, Weathers SP, Lang FF, Bhat KP, de Groot J, Majd NK. Molecular and clinical determinants of response to checkpoint inhibitor immunotherapy in glioblastoma. J Neurooncol 175(1):453-461, 2025. e-Pub 2025. PMID: 40560330.
Bander ED, Noll KR, Andrade de Almeida RA, Seaman SC, Banu M, Clark VE, Suki D, Wefel JS, Bradshaw M, Ferguson S, Weinberg JS, Lang FF, Prabhu SS. Relationships Between Surgical Approach, Tumor Classification Scheme, and Early Neurocognitive Outcome After Awake Craniotomy for Resection of Insular Glioma. Oper Neurosurg, 2025. e-Pub 2025. PMID: 40985652.
Young CC, Narsinh KH, Chen SR, Ansari SA, Hetts SW, Lang FF, Wintermark M, Kan PT. State of Practice: A Report from the Inaugural SNIS Neurointerventional Oncology Summit. AJNR Am J Neuroradiol 47(1):1-8, 2025. e-Pub 2025. PMID: 40592540.
Yeboa DN, Li J, Lin R, Prabhu SS, Beckham TH, Woodhouse K, Swanson TA, Weinberg JS, Wang X, Chi X, Ejezie CL, Suki D, Wang C, Ene C, McCutcheon IE, McGovern S, McAleer MF, Tom M, Ghia A, Perni S, Jiang W, De B, Chung C, Kim BYS, O'Brien BJ, Huse JT, Wefel JS, Court L, Tawbi H, Janku F, Guha-Thakurta N, Debnam JM, Johnson J, Taslicay CA, Alvarez-Breckenridge C, Raza SM, Heimberger AB, DeMonte F, North R, Briere TM, de Groot JF, Sawaya R, Grosshans D, Lang FF, Rao G, Ferguson SD. Therapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy: A Preliminary Analysis of a Randomized Clinical Trial. JAMA Oncol 11(8):890-899, 2025. e-Pub 2025. PMID: 40531511.
De A, Forero SA, Pirani A, Morales JE, De La Fuente-Granada M, Sebastian S, Huse JT, Ballester LY, Weinberg JS, Lang FF, Akdemir KC, McCarty JH. Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma. bioRxiv, 2025. e-Pub 2025. PMID: 40496929.
Zhao B, Cho CY, Ye L, Keal T, Mitchell T, Martin-Barrio I, Faraj CA, Unal M, Alsing J, Lawson NM, Kim ER, Chavez F, Rangel KM, Singh SK, McCarthy JH, Ashley DM, Yung WKA, Puduvalli V, Nir G, Weinberg JS, Wang L, Ligon KL, Genovese G, Loo PV, Futreal PA, Huse JT, Dixon JR, Lang FF, Akdemir KC. Oncogenic drivers shape the tumor microenvironment in human gliomas. bioRxiv, 2025. e-Pub 2025. PMID: 40475555.
Ma Y, Ayyadhury S, Singh S, Vashishath Y, Ozdemir C, McKee TD, Nguyen N, Basi A, Mak D, Gomez JA, Huse JT, Noor S, Winkowski D, Baird R, Weinberg JS, Lang FF, Burks JK, Bozdag S, Seeley EH, Ene CI. Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth. bioRxiv, 2025. e-Pub 2025. PMID: 40654923.
Ene, CI, Silva, E, Noll, KR, Bradshaw, ME, Connelly, K, Liu, HL, Tummala, R, Ferson, D, Lang Jr, FF, Kumar, VA. Language mapping during awake brain surgery in a deaf patient with a brain tumor. Journal of Neurosurgery: Case Lessons 9(18), 2025. e-Pub 2025. PMID: 40324327.
Poon CC, Herbrich SM, Chen Y, Hossain A, Fuller GN, Jindal S, Basu S, Ledbetter D, Macaluso M, Phillips LM, Gumin J, He Z, Parker Kerrigan BC, Singh SK, Singh P, Zaman MF, Ng Tang D, Goswami S, Lang FF, Sharma P. Mesenchymal stem cells and fibroblasts contribute to microvascular proliferation in glioblastoma and are correlated with immunosuppression and poor outcome. Cancer Immunol Res 13(6):804-820, 2025. e-Pub 2025. PMID: 40131028.
Faraj CA, McCutcheon IE, Gubbiotti MA, Perni S, Gule-Monroe MK, Akdemir K, Clark VE, Bander ED, Loghin ME, Prabhu SS, Lang FF, Weinberg JS. Extra-central nervous system metastasis from high-grade glioma: a single-institution experience. J Neurooncol 173(1):193-204, 2025. e-Pub 2025. PMID: 40055259.
Lawson NM, Ye L, Cho CY, Zhao B, Mitchell T, Martin-Barrio I, Beernaert B, Gupta A, Banu M, Lissanu Y, Shaffer S, Tawbi H, Li J, Gule-Monroe MK, Alvarez-Breckenridge CA, Huse JT, Murphy MB, Yin F, Lang FF, Parkes EE, Weinberg JS, Akdemir KC. Recurrent ERBB2 alterations are associated with esophageal adenocarcinoma brain metastases. medRxiv, 2025. e-Pub 2025. PMID: 40061311.
Lang Jr, FF, Weinberg, J, Ene, CI, Clark, VE, Zakaria, R, Al-Holou, W, Evans, L, Shepard, MJ, Everson, RG. Surgical management of infiltrative gliomas. Neurosurgical focus 59(2), 2025. e-Pub 2025. PMID: 40749244.
Stitzlein, LM, Nam, D, Hernandez, FA, Patel, KH, Poche, A, Ma, H, Impelman, K, Gumin, J, Wang, H, Wang, J, Gadd, S, Zaky, W, Becher, OJ, Dudley, RW, Lang, FF, Sareddy, GR, Chandra, J. Combined inhibition of lysine-specific demethylase 1 and kinase signaling as a preclinical treatment strategy in glioblastoma. Neuro-Oncology Advances 7(1), 2025. e-Pub 2025. PMID: 41497449.
Kumar VA, Perez A, Young AL, Jones J, O'Brien BJ, Lang FF, Huse JT, Fuller GN. Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma. Neuropathology 44(5):333-337, 2024. e-Pub 2024. PMID: 38414131.
Shanley M, Daher M, Dou J, Li S, Basar R, Rafei H, Dede M, Gumin J, Pantaleomicronn Garciotaa J, Nunez Cortes AK, He S, Jones CM, Acharya S, Fowlkes NW, Xiong D, Singh S, Shaim H, Hicks SC, Liu B, Jain A, Zaman MF, Miao Q, Li Y, Uprety N, Liu E, Muniz-Feliciano L, Deyter GM, Mohanty V, Zhang P, Evans SE, Shpall EJ, Lang FF, Chen K, Rezvani K. Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD. Cancer Cell 42(8):1450-1466.e11, 2024. e-Pub 2024. PMID: 39137729.
Gupta P, Dang M, Oberai S, Migliozzi S, Trivedi R, Kumar G, Peshoff M, Milam N, Ahmed A, Bojja K, Tran TM, Gumin J, Kamiya-Matsuoka C, Huse J, Cox K, Li J, Shehwana H, Sheth SA, Saxon R, Baohua S, Parker-Kerrigan B, Maheshwari A, Parra Cuentas ER, Navin NE, Heimberger AB, Lang FF, Iavarone A, Clise-Dwyer K, Wang L, Bhat KP. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. Neuro Oncol 26(12):2239-2255, 2024. e-Pub 2024. PMID: 39126294.
Bhoopathi P, Mannangatti P, Pradhan AK, Kumar A, Maji S, Lang FF, Klibanov AL, Madan E, Cavenee WK, Keoprasert T, Sun D, Bjerkvig R, Thorsen F, Gogna R, Das SK, Emdad L, Fisher PB. Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus. J Cell Physiol 239(8), 2024. e-Pub 2024. PMID: 38775127.
Chakraborty S, Wei D, Tran M, Lang FF, Newman RA, Yang P. PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death. Neoplasia 54:101008, 2024. e-Pub 2024. PMID: 38823209.
Parney IF, Warnick RE, Lang FF, Rutka JT, Kalkanis S, Glick R, Rosenblum ML, Germano IM. The AANS/CNS Section on Tumors: a summary of 40 years of advocacy to advance the care of patients with brain and spine tumors. J Neurosurg 141(1):1-7, 2024. e-Pub 2024. PMID: 38277647.
Peshoff MM, Gupta P, Oberai S, Trivedi R, Katayama H, Chakrapani P, Dang M, Migliozzi S, Gumin J, Kadri DB, Lin JK, Milam NK, Maynard ME, Vaillant BD, Parker-Kerrigan B, Lang FF, Huse JT, Iavarone A, Wang L, Clise-Dwyer K, Bhat KP. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. Neuro Oncol 26(5):826-839, 2024. e-Pub 2024. PMID: 38237157.
Ene CI, Abi Faraj C, Beckham TH, Weinberg JS, Andersen CR, Haider AS, Rao G, Ferguson SD, Alvarez-Brenkenridge CA, Kim BYS, Heimberger AB, McCutcheon IE, Prabhu SS, Wang CM, Ghia AJ, McGovern SL, Chung C, McAleer MF, Tom MC, Perni S, Swanson TA, Yeboa DN, Briere TM, Huse JT, Fuller GN, Lang FF, Li J, Suki D, Sawaya RE. Response of treatment-naive brain metastases to stereotactic radiosurgery. Nat Commun 15(1):3728, 2024. e-Pub 2024. PMID: 38697991.
Ledbetter D, Gumin J, Phillips L, Ene C, Shimizu Y, Lang FF. Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique. J Vis Exp 2024(205), 2024. e-Pub 2024. PMID: 38557500.
Shin DH, Jiang H, Gillard AG, Kim D, Fan X, Singh SK, Nguyen TT, Sohoni SS, Lopez-Rivas AR, Parthasarathy A, Ene CI, Gumin J, Lang FF, Alonso MM, Gomez-Manzano C, Fueyo J. Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice. Mol Ther 32(3):722-733, 2024. e-Pub 2024. PMID: 38311852.
McDonald MF, Hossain A, Momin EN, Hasan I, Singh S, Adachi S, Gumin J, Ledbetter D, Yang J, Long L, Daou M, Gopakumar S, Phillips LM, Parker Kerrigan B, Lang FF. Tumor-specific Polycistronic miRNA Delivered by Engineered Exosomes for the Treatment of Glioblastoma. Neuro Oncol 26(2):236-250, 2024. e-Pub 2024. PMID: 37847405.
Wang DH, Fujita Y, Dono A, Rodriguez Armendariz AG, Shah M, Putluri N, Pichardo-Rojas PS, Patel CB, Zhu JJ, Huse JT, Parker Kerrigan BC, Lang FF, Esquenazi Y, Ballester LY. The genomic alterations in glioblastoma influence the levels of CSF metabolites. Acta Neuropathol Commun 12(1):13, 2024. e-Pub 2024. PMID: 38243318.
Kan P, Srinivasan VM, Gumin J, Garcia R, Chen SR, Johnson JN, Collins DE, Chen MM, Ledbetter D, Huse J, Evan Luna ZA, Robledo A, Vasandani V, Rao A, Singh SK, Shpall EJ, Fueyo J, Gomez-Manzano C, Lang FF. Development of a Rabbit Human Glioblastoma Model for Testing of Endovascular Selective Intra-Arterial Infusion (ESIA) of Novel Stem Cell-Based Therapeutics. Neuro Oncol 26(1):127-136, 2024. e-Pub 2024. PMID: 37603323.
Arjuna S, Shah M, Dono A, Nunez-Rubiano L, Pichardo-Rojas PS, Zhu JJ, Riascos RF, Luthra R, Roy-Chowdhuri S, Duose D, Wang DH, Lang FF, Esquenazi Y, Ballester LY. Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer. J Neurooncol 166(1):39-49, 2024. e-Pub 2024. PMID: 38160230.
Leong VWS, Khan S, Sharma P, Wu S, Thomas RR, Li X, Singh SK, Lang FF, Yung AWK, Koul D. MGMT function determines the differential response of ATR inhibitors with DNA-damaging agents in glioma stem cells for GBM therapy. Neurooncol Adv 6(1):vdad165, 2024. e-Pub 2024. PMID: 38213834.
Yu KKH, Basu S, Baquer G, Ahn R, Gantchev J, Jindal S, Regan MS, Abou-Mrad Z, Prabhu MC, Williams MJ, D'Souza AD, Malinowski SW, Hopland K, Elhanati Y, Stopka SA, Stortchevoi A, He Z, Sun J, Chen Y, Espejo AB, Chow KH, Yerrum S, Kao PL, Kerrigan BP, Norberg L, Nielsen D, TeamLab GBM, Puduvalli VK, Huse J, Beroukhim R, Kim YSB, Goswami S, Boire A, Frisken S, Cima MJ, Holdhoff M, Lucas CG, Bettegowda C, Levine SS, Bale TA, Brennan C, Reardon DA, Lang FF, Antonio Chiocca E, Ligon KL, White FM, Sharma P, Tabar V, Agar NYR. Investigative needle core biopsies for multi-omics in Glioblastoma. medRxiv, 2023. e-Pub 2023. PMID: 38234840.
Haider AS, McCutcheon IE, Ene CI, Fuller GN, Schomer DF, Gule-Monroe M, DeMonte F, Ferguson SD, Lang FF, Prabhu SS, Raza SM, Suki D, Weinberg JS, Sawaya R. Subependymomas of the fourth ventricle: To operate or not to operate?. J Clin Neurosci 118:147-152, 2023. e-Pub 2023. PMID: 37944358.
De A, Lattier JM, Morales JE, Kelly JR, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse JT, Lang FF, McCarty JH. Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative Versus Invasive Cell States in Glioblastoma. J Neurosci 43(47):8043-8057, 2023. e-Pub 2023. PMID: 37722850.
Goswami S, Raychaudhuri D, Singh P, Natarajan SM, Chen Y, Poon C, Hennessey M, Tannir AJ, Zhang J, Anandhan S, Kerrigan BP, Macaluso MD, He Z, Jindal S, Lang FF, Basu S, Sharma P. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer 4(10):1455-1473, 2023. e-Pub 2023. PMID: 37653141.
Zheng C, Wei Y, Zhang Q, Sun M, Wang Y, Hou J, Zhang P, Lv X, Su D, Jiang Y, Gumin J, Sahni N, Hu B, Wang W, Chen X, McGrail DJ, Zhang C, Huang S, Xu H, Chen J, Lang FF, Hu J, Chen Y. Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Sci Adv 9(31):eadf3984, 2023. e-Pub 2023. PMID: 37540752.
Hasanov M, Milton DR, Davies AB, Sirmans E, Saberian C, Posada EL, Opusunju S, Gershenwald JE, Torres-Cabala CA, Burton EM, Colen RR, Huse JT, Glitza Oliva IC, Chung C, McAleer MF, McGovern SL, Yeboa DN, Kim BYS, Prabhu SS, McCutcheon IE, Weinberg JS, Lang FF, Tawbi HA, Li J, Haydu LE, Davies MA, Ferguson SD. Changes In Outcomes And Factors Associated With Survival In Melanoma Patients With Brain Metastases. Neuro Oncol 25(7):1310-1320, 2023. e-Pub 2023. PMID: 36510640.
Jiang, H, Shin, DH, Yi, Y, Fan, X, Gumin, J, He, J, Gillard, A, Lang Jr, FF, Gomez-Manzano, C, Fueyo-Margareto, J. Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity. Cancer Research Communications 3(6):1118-1131, 2023. e-Pub 2023. PMID: 37379361.
Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, Á L, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh G. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 29(6):1370-1378, 2023. e-Pub 2023. PMID: 37188783.
Jiang H, Shin DH, Yi Y, Fan X, Gumin J, He J, Gillard AG, Lang FF, Gomez-Manzano C, Fueyo J. Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity. Cancer Res Commun 3(6):1118-1131, 2023. e-Pub 2023. PMID: 37379361.
Stitzlein LM, Gangadharan A, Walsh LM, Nam D, Espejo AB, Singh MM, Patel KH, Lu Y, Su X, Ezhilarasan R, Gumin J, Singh S, Sulman E, Lang FF, Chandra J. Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles. Front Neurol 14:1112207, 2023. e-Pub 2023. PMID: 37082446.
Al-Holou WN, Suki D, Hodges TR, Everson RG, Freeman J, Ferguson SD, McCutcheon IE, Prabhu SS, Weinberg JS, Sawaya R, Lang FF. Circumferential sulcus-guided resection technique for improved outcomes of low-grade gliomas. J Neurosurg 137(4):1-11, 2022. e-Pub 2022. PMID: 34996044.
Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer 10(7), 2022. e-Pub 2022. PMID: 35902132.
Gállego Pérez-Larraya J, Garcia-Moure M, Labiano S, Patiño-García A, Dobbs J, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, Puigdelloses M, Laspidea V, Astigarraga I, Lopez-Ibor B, Cruz O, Oscoz Lizarbe M, Hervas-Stubbs S, Alkorta-Aranburu G, Tamayo I, Tavira B, Hernandez-Alcoceba R, Jones C, Dharmadhikari G, Ruiz-Moreno C, Stunnenberg H, Hulleman E, van der Lugt J, MÁ I, Diez-Valle R, Esparragosa Vázquez I, Villalba M, de Andrea C, Núñez-Córdoba JM, Ewald B, Robbins J, Fueyo J, Gomez-Manzano C, Lang FF, Tejada S, Alonso MM. Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med 386(26):2471-2481, 2022. e-Pub 2022. PMID: 35767439.
Chen SR, Chen MM, Ene C, Lang FF, Kan P. Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors. J Neurointerv Surg 14(6):533-538, 2022. e-Pub 2022. PMID: 34824133.
Xu J, Wu PJ, Lai TH, Sharma P, Canella A, Welker AM, Beattie C, Timmers CD, Lang FF, Jacob NK, Elder JB, Lonser R, Easley M, Pietrzak M, Sampath D, Puduvalli VK. Disruption of DNA Repair and Survival Pathways through Heat Shock Protein inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation therapy. Clin Cancer Res 28(9):1979-1990, 2022. e-Pub 2022. PMID: 35140124.
Chen SR, Lang FF, Kan P. Preclinical animal brain tumor models for interventional neuro-oncology. J Neurointerv Surg 14(5):417-418, 2022. e-Pub 2022. PMID: 35414632.
Tan Y, Wang ZK, Lang FF, Yu HM, Cao C, Ni CY, Wang MY, Song YL, Lang JP. Construction of cluster-based supramolecular wire and rectangle. Dalton Trans 51(16):6358-6365, 2022. e-Pub 2022. PMID: 35383821.
van Putten EHP, Kleijn A, van Beusechem VW, Noske D, Lamers CHJ, de Goede AL, Idema S, Hoefnagel D, Kloezeman JJ, Fueyo J, Lang FF, Teunissen CE, Vernhout RM, Bakker C, Gerritsen W, Curiel DT, Vulto A, Lamfers MLM, Dirven CMF. Convection enhanced delivery of the oncolytic adenovirus Delta24-RGD in recurrent GBM patients; a phase I clinical trial including correlative studies. Clin Cancer Res 28(8):1572-1585, 2022. e-Pub 2022. PMID: 35176144.
Li T, Mehraein-Ghomi F, Forbes ME, Namjoshi SV, Ballard EA, Song Q, Chou PC, Wang X, Parker Kerrigan BC, Lang FF, Lesser G, Debinski W, Yang X, Zhang W. HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion. Mol Ther 30(4):1610-1627, 2022. e-Pub 2022. PMID: 35151844.
Vogelbaum MA, Li G, Heimberger AB, Lang FF, Fueyo J, Gomez-Manzano C, Sanai N. A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. Am Soc Clin Oncol Educ Book 42:1-8, 2022. e-Pub 2022. PMID: 35580289.
Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF. Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. J Neurosurg 136(3):1-11, 2022. e-Pub 2022. PMID: 34450587.
Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, Baskin DS, Pichumani K, Ijare OB, Wood SL, Powell SZ, Haviland DL, Parker Kerrigan BC, Lang FF, Prabhu SS, Huntoon KM, Jiang W, Kim BYS, George J, Yun K. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun 13(1):767, 2022. e-Pub 2022. PMID: 35140215.
Sharma P, Xu J, Williams K, Easley M, Elder JB, Lonser R, Lang FF, Lapalombella R, Sampath D, Puduvalli VK. Inhibition of nicotinamide phosphoribosyltransferase, the rate-limiting enzyme of the nicotinamide adenine dinucleotide salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress. Neuro Oncol 24(2):229-244, 2022. e-Pub 2022. PMID: 34260721.
Shepard MJ, Haider AS, Prabhu SS, Sawaya R, DeMonte F, McCutcheon IE, Weinberg JS, Ferguson SD, Suki D, Fuller GN, Lang FF. Long term outcomes following surgery for pineal region tumors. J Neurooncol 156(3):491-498, 2022. e-Pub 2022. PMID: 35083579.
Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun 13(1):190, 2022. e-Pub 2022. PMID: 34987156.
Modrek AS, Eskilsson E, Ezhilarasan R, Wang Q, Goodman LD, Ding Y, Zhang ZY, Bhat KPL, Le TT, Barthel FP, Tang M, Yang J, Long L, Gumin J, Lang FF, Verhaak RGW, Aldape KD, Sulman EP. PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells. Front Oncol 12:941657, 2022. e-Pub 2022. PMID: 36059614.
Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI) 4(4), 2021. e-Pub 2021. PMID: 35937580.
Phillips LM, Li S, Gumin J, Daou M, Ledbetter D, Yang J, Singh S, Parker Kerrigan BC, Hossain A, Yuan Y, Gomez-Manzano C, Fueyo J, Lang FF. An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus. Neuro Oncol 23(11):1911-1921, 2021. e-Pub 2021. PMID: 34059921.
Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, Sulman EP, Lorenzi PL, Tan L, Shan M, Tolstyka ZP, Kachman M, Zhang L, Gao S, Deem AK, Genovese G, Scaglioni PP, Lyssiotis CA, Viale A, Draetta GF. Medium-chain acyl CoA dehydrogenase protects mitochondria from lipid peroxidation in glioblastoma. Cancer Discov 11(11):2904-2923, 2021. e-Pub 2021. PMID: 34039636.
Khan S, Mahalingam R, Sen S, Martinez-Ledesma E, Khan A, Gandy K, Lang FF, Sulman EP, Alfaro-Munoz KD, Majd NK, Balasubramaniyan V, de Groot JF. Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells. Cancers (Basel) 13(21), 2021. e-Pub 2021. PMID: 34771447.
Salzillo TC, Mawoneke V, Weygand J, Shetty A, Gumin J, Zacharias NM, Gammon ST, Piwnica-Worms D, Fuller GN, Logothetis CJ, Lang FF, Bhattacharya PK. Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells 10(10), 2021. e-Pub 2021. PMID: 34685601.
Srinivasan VM, Hadley CC, Patel AJ, Ehni BL, Weiner HL, Rao G, Lang FF, Sawaya RE, Yoshor D. The history of neurosurgery at Baylor College of Medicine. J Neurosurg 135(4):1-11, 2021. e-Pub 2021. PMID: 33607618.
Fueyo J, Gomez-Manzano C, Lang FF, Alonso MM. Hitchhiking to brain tumours: stem cell delivery of oncolytic viruses. Lancet Oncol 22(8):1049-1051, 2021. e-Pub 2021. PMID: 34214494.
Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Mielke S, Eyrich M, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K. Targeting the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest 131(14), 2021. e-Pub 2021. PMID: 34138753.
Quirarte JA, Kumar VA, Liu HL, Noll KR, Wefel JS, Lang FF. Language supplementary motor area syndrome correlated with dynamic changes in perioperative task-based functional MRI activations: case report. J Neurosurg 134(6):1-5, 2021. e-Pub 2020. PMID: 32502992.
Shin, DH, Nguyen, T, Ozpolat, B, Lang Jr, FF, Alonso, MM, Gomez-Manzano, C, Fueyo-Margareto, J. Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy. Journal for immunotherapy of cancer 9(4), 2021. e-Pub 2021. PMID: 33795384.
Antonio Chiocca, E, Lang Jr, FF, Markert, JM. Gene and viral therapy for glioblastoma multiforme. Neurosurgical focus 50(2):1, 2021. e-Pub 2021.
Ene CI, Fueyo J, Lang FF. Delta-24 adenoviral therapy for glioblastoma: evolution from the bench to bedside and future considerations. Neurosurg Focus 50(2):E6, 2021. e-Pub 2021. PMID: 33524949.
Srinivasan VM, Lang FF, Kan P. Intraarterial delivery of virotherapy for glioblastoma. Neurosurg Focus 50(2):E7, 2021. e-Pub 2021. PMID: 33524944.
Srinivasan VM, Gumin J, Camstra KM, Collins DE, Chen MM, Shpall EJ, Parker Kerrigan BC, Johnson JN, Chen SR, Fueyo J, Gomez-Manzano C, Lang FF, Kan P. Endovascular Selective Intra-Arterial Infusion of Mesenchymal Stem Cells Loaded With Delta-24 in a Canine Model. Neurosurgery 88(1):E102-E113, 2020. e-Pub 2020. PMID: 33231254.
Lattier JM, De A, Chen Z, Morales JE, Lang FF, Huse JT, McCarty JH. Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene 39(50):7253-7264, 2020. e-Pub 2020. PMID: 33040087.
Srinivasan VM, Gumin J, Camstra KM, Chen SR, Johnson JN, Shimizu Y, Parker Kerrigan BC, Shpall EJ, Lang FF, Kan P. Microcatheter delivery of neurotherapeutics: compatibility with mesenchymal stem cells. J Neurosurg 6:1-9, 2020. e-Pub 2020. PMID: 31491769.
Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight 5(17), 2020. e-Pub 2020. PMID: 32721947.
Weathers SP, Penas-Prado M, Pei BL, Ling X, Kassab C, Banerjee P, Bdiwi M, Shaim H, Alsuliman A, Shanley M, de Groot JF, O'Brien BJ, Harrison R, Majd N, Kamiya-Matsuoka C, Fuller GN, Huse JT, Chi L, Rao G, Weinberg JS, Lang FF, Sawaya R, Shpall EJ, Rezvani K, Heimberger AB. Glioblastoma-mediated immune dysfunction limits CMV-specific T cells and therapeutic responses; results from a Phase I/II trial. Clin Cancer Res 26(14):3565-3577, 2020. e-Pub 2020. PMID: 32299815.
Kumar VA, Heiba IM, Prabhu SS, Chen MM, Colen RR, Young AL, Johnson JM, Hou P, Noll K, Ferguson SD, Rao G, Lang FF, Schomer DF, Liu HL. The role of resting-state functional MRI for clinical preoperative language mapping. Cancer Imaging 20(1):47, 2020. e-Pub 2020. PMID: 32653026.
Narayan RS, Molenaar P, Teng J, Cornelissen FMG, Roelofs I, Menezes R, Dik R, Lagerweij T, Broersma Y, Petersen N, Marin Soto JA, Brands E, van Kuiken P, Lecca MC, Lenos KJ, Veld SGJG I', van Wieringen W, Lang FF, Sulman E, Verhaak R, Baumert BG, Stalpers LJA, Vermeulen L, Watts C, Bailey D, Slotman BJ, Versteeg R, Noske D, Sminia P, Tannous BA, Wurdinger T, Koster J, Westerman BA. A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities. Nat Commun 11(1):2935, 2020. e-Pub 2020. PMID: 32523045.
de Groot J, Penas-Prado M, Alfaro-Munoz K, Hunter K, Pei BL, O'Brien B, Weathers SP, Loghin M, Kamiya Matsouka C, Yung WKA, Mandel J, Wu J, Yuan Y, Zhou S, Fuller GN, Huse J, Rao G, Weinberg JS, Prabhu SS, McCutcheon IE, Lang FF, Ferguson SD, Sawaya R, Colen R, Yadav SS, Blando J, Vence L, Allison J, Sharma P, Heimberger AB. Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro Oncol 22(4):539-549, 2020. e-Pub 2020. PMID: 31755915.
de Groot J, Penas-Prado M, Alfaro-Munoz K, Hunter K, Pei BL, O'Brien B, Weathers SP, Loghin M, Kamiya Matsouka C, Yung WKA, Mandel J, Wu J, Yuan Y, Zhou S, Fuller GN, Huse J, Rao G, Weinberg JS, Prabhu SS, McCutcheon IE, Lang FF, Ferguson SD, Sawaya R, Colen R, Yadav SS, Blando J, Vence L, Allison J, Sharma P, Heimberger AB. Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro Oncol 22(4):539-549, 2020. e-Pub 2020.
Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA. Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment. Cancer Discov 10:371-381, 2020. e-Pub 2020.
Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA. Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer Discov 10(3):371-381, 2020. e-Pub 2020. PMID: 31919052.
Al-Holou WN, Hodges TR, Everson RG, Freeman J, Zhou S, Suki D, Rao G, Ferguson SD, Heimberger AB, McCutcheon IE, Prabhu SS, Lang FF, Weinberg JS, Wildrick DM, Sawaya R. Perilesional resection of glioblastoma is independently associated with improved outcomes. Neurosurgery 86(1):112-121, 2020. e-Pub 2020. PMID: 30799490.
Parker Kerrigan BC, Ledbetter D, Kronowitz M, Phillips L, Gumin J, Hossain A, Yang J, Mendt M, Singh S, Cogdell D, Ene C, Shpall E, Lang FF. RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine. Neurooncol Adv 2(1):vdaa132, 2020. e-Pub 2020. PMID: 33241214.
Jiang H, Shin DH, Nguyen TT, Fueyo J, Fan X, Henry V, Carrillo CC, Yi Y, Alonso MM, Collier TL, Yuan Y, Lang FF, Gomez-Manzano C. Localized treatment with oncolytic adenovirus Delta-24-RGDOX induces systemic immunity against disseminated subcutaneous and intracranial melanomas. Clin Cancer Res 25(22):6801-6814, 2019. e-Pub 2019. PMID: 31455679.
Marisetty AL, Lu L, Veo BL, Liu B, Coarfa C, Kamal MM, Kassem DH, Irshad K, Lu Y, Gumin J, Henry V, Paulucci-Holthauzen A, Rao G, Baladandayuthapani V, Lang FF, Fuller GN, Majumder S. REST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis. Neuro Oncol 21:775-785, 2019. e-Pub 2019. PMID: 30953587.
Rivera-Molina Y, Jiang H, Fueyo J, Nguyen T, Shin DH, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang FF, Gomez-Manzano C. GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory. Neurooncol Adv 1:vdz009, 2019. e-Pub 2019. PMID: 31608328.
Kudo Y, Haymaker C, Zhang J, Reuben A, Duose DY, Fujimoto J, Roy-Chowdhuri S, Solis Soto LM, Dejima H, Parra ER, Mino B, Abraham R, Ikeda N, Vaporcyan A, Gibbons D, Zhang J, Lang FF, Luthra R, Lee JJ, Moran C, Huse JT, Kadara H, Wistuba II. Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small cell lung cancer. Ann Oncol 30:1521-1530, 2019. e-Pub 2019. PMID: 31282941.
Bastos DCA, Maldaun MVC, Sawaya R, Suki D, Lang FF, Brown PD, Rao G, Weinberg JS, Prabhu SS. Biological subtypes and survival outcomes in breast cancer patients with brain metastases in the targeted therapy era. Neurooncol Pract 5:161-169, 2019. e-Pub 2019.
Bastos DCA, Maldaun MVC, Sawaya R, Suki D, Lang FF, Brown PD, Rao G, Weinberg JS, Prabhu SS. Biological subtypes and survival outcomes in breast cancer patients with brain metastases in the targeted therapy era. Neurooncol Pract 5(3):161-169, 2018. e-Pub 2018. PMID: 31386016.
Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang F, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Atrx inactivation drives disease-defining, phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun 9:1057, 2018. e-Pub 2018. PMID: 29535300.
Olar A, Goodman LD, Wani KM, Boehling NS, Sharma DS, Mody RR, Gumin J, Claus EB, Lang FF, Cloughesy TF, Lai A, Aldape KD, DeMonte F, Sulman EP. A gene expression signature predicts recurrence-free survival in meningioma. Oncotarget 9:16087-16098, 2018. e-Pub 2018. PMID: 29662628.
Gireud-Goss M, Reyes S, Wilson M, Farley M, Memarzadeh K, Srinivasan S, Sirisaengtaksin N, Yamashita S, Tsunoda S, Lang FF, Waxham MN, Bean AJ. Distinct mechanisms enable inward or outward budding from late endosomes/multivesicular bodies. Exp Cell Res 372:1-15, 2018. e-Pub 2018. PMID: 30144444.
Zinn PO, Singh SK, Kotrotsou A, Hassan I, Thomas G, Luedi MM, Elakkad A, Elshafeey N, Idris T, Mosley J, Gumin J, Fuller GN, deGroot JF, Baladandayuthapani V, Sulman EP, Kumar AJ, Sawaya R, Lang FF, Piwnica-Worms D, Colen RR. A co-clinical radiogenomic validation study: Conserved magnetic resonance radiomic appearance of Periostin expressing glioblastoma in patients and xenograft models. Clin Cancer Res 24:6288-6299, 2018. e-Pub 2018. PMID: 30054278.
Gogia B, Chavali LS, Lang FF, Hayman LA, Rai P, Prabhu SS, Schomer DF, Kumar VA. MRI venous architecture of insula. J Neurol Sci 390:156-161, 2018. e-Pub 2018. PMID: 29801878.
Tiwary S, Morales JE, Kwiatkowski SC, Lang FF, Rao G, McCarty JH. Metastatic brain tumors disrupt the blood-brain barrier and alter lipid metabolism by inhibiting expression of the endothelial cell fatty acid transporter Mfsd2a. Sci Rep 8:8267, 2018. e-Pub 2018. PMID: 29844613.
Qiao Y, Gumin J, MacLellan CJ, Gao F, Bouchard R, Lang FF, Stafford RJ, Melancon MP. Magnetic resonance and photoacoustic imaging of brain tumor mediated by mesenchymal stem cell labeled with multifunctional nanoparticle introduced via carotid artery injection. Nanotechnology 29:165101, 2018. e-Pub 2018. PMID: 29438105.
Luedi MM, Singh SK, Mosley JC, Hassan ISA, Hatami M, Gumin J, Andereggen L, Sulman EP, Lang FF, Stueber F, Fuller GN, Colen RR, Zinn PO. Dexamethasone-mediated oncogenicity in vitro and in an animal model of glioblastoma. J Neurosurg 129:1446-1455, 2018. e-Pub 2018. PMID: 29328002.
Mostovenko E, Vegvari A, Rezeli M, Lichti C, Fenyo D, Wang Q, Lang FF, Sulman E, Sahlin KB, Marko-Varga G, Nilsson CL. Large scale identification of variant proteins in glioma stem cells. ACS Chem Neurosci 9:73-79, 2018. e-Pub 2018. PMID: 29254333.
Lang FM, Hossain A, Gumin J, Momin EN, Shimizu Y, Ledbetter D, Shahar T, Yamashita S, Parker Kerrigan B, Fueyo J, Sawaya R, Lang FF. Mesenchymal stem cells as natural bio-factories for exosomes carrying miR-124a in the treatment of gliomas. Neuro Oncol 20:380-390, 2018. e-Pub 2018. PMID: 29016843.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape K, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CM, Tejada S, Diez Valle R, Alonso MA, Ewald B, Peterkin JJ, Tufaro F, Fueyo J. Phase 1 study of DNX-2401 (Delta-24-RGD) oncolytic adenovirus: replication and immunotherapeutic effects in recurrent malignant glioma. J Clin Oncol 36:1419-1427, 2018. e-Pub 2018. PMID: 29432077.
Ferguson S, Levine N, Suki D, Tsung A, Lang FF, Sawaya R, Weinberg JS, McCutcheon IE. The surgical treatment of tumors of the fourth ventricle: a single-institution experience. J Neurosurg 128:339-351, 2018. e-Pub 2018. PMID: 28409732.
Parker Kerrigan B, Hossain A, Yamashita S, Lang FF. Stem Cell Therapy of Gliomas. Prog Neurol Surg 32:124-151, 2018. e-Pub 2018. PMID: 29990980.
Jiang H, Rivera-Molina Y, Gomez-Manzano C, Clise-Dwyer K, Bover L, Vence LM, Yuan Y, Lang FF, Toniatti C, Hossain MB, Fueyo J. Oncolytic adenovirus and tumor-targeting immune modulatory therapy improve autologous cancer vaccination. Cancer Res 77:3894-3907, 2017. e-Pub 2017. PMID: 28566332.
Shahar T, Rozovski U, Hess KR, Hosain A, Gumin J, Gao F, Fuller GN, Goodman L, Sulman EP, Lang FF. Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival. Neuro Oncol 19:660-668, 2017. e-Pub 2017. PMID: 28453745.
Figueroa JM, Skog J, Akers J, Li H, Komotar R, Jensen R, Ringel F, Yang I, Kalkanis S, Thompson R, LoGuidice L, Berghoff E, Parsa A, Liau L, Curry W, Cahill D, Bettegowda C, Lang FF, Chiocca EA, Henson J, Kim R, Breakefield X, Chen C, Messer K, Hochberg F, Carter BS. Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. Neuro Oncol 19:1494-1502, 2017. e-Pub 2017. PMID: 28453784.
Guerrero PA, Tchaicha JH, Chen Z, Morales JE, McCarty N, Wang Q, Sulman EP, Fuller G, Lang FF, Rao G, McCarty JH. Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression. Oncogene 36:6568-6580, 2017. e-Pub 2017. PMID: 28783169.
Thomas JG, Parker Kerrigan BC, Hossain A, Gumin J, Shinojima N, Nwajei F, Ezhilarasan R, Love P, Sulman EP, Lang FF. Ionizing radiation augments glioma tropism of mesenchymal stem cells. J Neurosurg 31:1-9, 2017. e-Pub 2017. PMID: 28362237.
Parker Kerrigan BC, Shimizu Y, Andreeff M, Lang FF. Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas. Cytotherapy 19:445-457, 2017. e-Pub 2017. PMID: 28233640.
Canella A, Welker AM, Yoo JY, Xu J, Abas FS, Kesanakurti D, Nagarajan P, Beattie CE, Sulman EP, Liu J, Gumin J, Lang FF, Gurcan MN, Kaur B, Sampath D, Puduvalli VK. Efficacy of onalespib, a long-acting second-generation HSP90 inhibitor, as a single agent and in combination with temozolomide against malignant gliomas. Clin Cancer Res 23:6215-6226, 2017. e-Pub 2017. PMID: 28679777.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G. Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1040-1048, 2017. e-Pub 2017. PMID: 28687375.
Figueroa JM, Philips L, Shahar T, Hossain A, Gumin J, Kim H, Bean AJ, Calin GA, Fueyo J, Walters ET, Kalluri R, Verhaak R, Lang FF. Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587. Cancer Res 77:5808-5819, 2017. e-Pub 2017. PMID: 28855213.
Luedi MM, Singh SK, Mosley JC, Hatami M, Gumin J, Sulman EP, Lang FF, Stueber F, Zinn PO, Colen RR. A dexamethasone-regulated gene signature is prognostic for poor survival in glioblastoma patients. J Neurosurg Anesthesiol 29:46-58, 2017. e-Pub 2017. PMID: 27653222.
Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Puerta Martinez F, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Mol Cell Biol 37:pii: e00142-17, 2017. e-Pub 2017. PMID: 28760776.
Jiang C, Zhu Y, Zhou Z, Gumin J, Bengtsson L, Wu W, Songyang Z, Lang FF, Lin X. TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression. Oncogene 36:2813-2823, 2017. e-Pub 2017. PMID: 27991920.
Hu J, Salzillo TC, Sailasuta N, Lang FF, Bhattacharya P. Interrogating IDH mutation in brain tumor: magnetic resonance and hyperpolarization. Top Magn Reson Imaging 26:27-32, 2017. e-Pub 2017. PMID: 28079713.
Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo-Margareto J, Lang FF, Fleming JB. Preclinical evaluation of sequential combination of oncolytic adenovirus Delta-24-RGD and phosphatidylserine-targeting antibody in pancreatic ductal adenocarcinoma. Mol Cancer Ther 16:662-670, 2017. e-Pub 2017. PMID: 28138026.
Au K, Ram Z, Zadeh G, Aldape K, Balogun J, Barani I, DiMeco F, Goel A, Khu K, Lang FF, Lund-Johansen M, Maldaun M, Tabatabai G, Tonn JC, Westphal M. Proceedings of the WFNS Neuro-Oncology Committee Workshop Rome 2015. Surg Neurol Int 7:S963-S975, 2016. e-Pub 2016. PMID: 28217379.
Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv 2:e1501290, 2016. e-Pub 2016. PMID: 27757426.
Cheerathodi M, Avci NG, Guerrero PA, Tang LK, Popp J, Morales JE, Chen Z, Carnero A, Lang FF, Ballif BA, Rivera GM, McCarty JH. The cytoskeletal adapter protein spinophilin regulates invadopodia dynamics and tumor cell invasion in glioblastoma. Mol Cancer Res 14:1277-1287, 2016. e-Pub 2016. PMID: 27655131.
Mahajan A, Ahmed S, Li J, McAleer MF, Weinberg J, Brown PD, Prabhu S, Lang FF, McGovern SL, McCutcheon IE, Heimberger A, Sulman EP, Ghia AJ, Ferguson S, Hess K, Rao G. Postoperative stereotactic radiosurgery versus observation for completely resected brain metastases: results of a prospective randomized study. Int J Radiat Oncol Biol Phys 96:S2, 2016. e-Pub 2016. PMID: 27675774.
Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, Weygand J, Dutta P, Pudakalakatti S, Millward NZ, Gammon ST, Lang FF, Heimberger AB, Bhattacharya PK. Interrogating metabolism in brain cancer. Magn Reson Imaging Clin N Am 24:687-703, 2016. e-Pub 2016.
Xipell E, Gonzalez-Huarriz M, de Irujo JJ, García-Garzón A, Lang FF, Jiang H, Fueyo J, Gomez-Manzano C, Alonso MM. Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma. Oncotarget 7:30626-41, 2016. e-Pub 2016. PMID: 27121320.
Zinn PO, Singh SK, Kotrotsou A, Zandi F, Thomas G, Hatami M, Luedi MM, Elakkad A, Hassan I, Gumin J, Sulman EP, Lang FF, Colen RR. Clinically applicable and biologically validated MRI radiomic test method predicts glioblastoma genomic landscape and survival. Neurosurgery *(Won the National Brain Tumor Society Mahaley Clinical Research Award when presented at the CNS 2016 meeting) 63 Suppl 1:156-157, 2016. e-Pub 2016. PMID: 27399418.
Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med 14:46, 2016. e-Pub 2016. PMID: 26861698.
Xipell E, Aragón T, Martínez-Velez N, Vera B, Idoate MA, Martínez-Irujo JJ, Garzón AG, Gonzalez-Huarriz M, Acanda AM, Jones C, Lang FF, Fueyo J, Gomez-Manzano C, Alonso MM. Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol 18:1109-19, 2016. e-Pub 2016. PMID: 26951384.
Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano C. Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Oncotarget 7:16146-57, 2016. e-Pub 2016. PMID: 26910374.
Hossain A, Gumin J, Gao F, Figueroa J, Shinojima N, Takezaki T, Priebe W, Villarreal D, Kang SG, Joyce C, Sulman E, Wang Q, Marini FC, Andreeff M, Colman H, Lang FF. Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway. Stem Cells 33(8):2400-15, 2015. e-Pub 2015. PMID: 25966666.
Jiang H, Gomez-Manzano C, Rivera-Molina Y, Lang FF, Conrad CA, Fueyo J. Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints. Curr Opin Virol 13:33-39, 2015. e-Pub 2015. PMID: 25863716.
Wildburger NC, Wood PL, Gumin J, Lichti CF, Emmett MR, Lang FF, Nilsson CL. ESI-MS/MS and MALDI-IMS localization reveal alterations in phosphatidic acid, diacylglycerol, and DHA in glioma stem cell xenografts. J Proteome Res 14(6):2511-9, 2015. e-Pub 2015. PMID: 25880480.
Li X, Liu Y, Granberg KJ, Wang Q, Moore LM, Ji P, Gumin J, Sulman EP, Calin GA, Haapasalo H, Nykter M, Shmulevich I, Fuller GN, Lang FF, Zhang W. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene 34(13):1619-28, 2015. e-Pub 2015. PMID: 24747968.
Nilsson CL, Mostovenko E, Lichti CF, Ruggles K, Fenyo D, Rosenbloom KR, Hancock WS, Paik YK, Omenn GS, LaBaer J, Kroes RA, Uhlén M, Hober S, Vegvari A, Andrén PE, Sulman EP, Lang FF, Fuentes M, Carlsohn E, Emmett MR, Moskal JR, Berven FS, Fehniger TE, Marko-Varga G. Use of ENCODE resources to characterize novel proteoforms and missing proteins in the human proteome. J Proteome Res 14(2):603-8, 2015. e-Pub 2015. PMID: 25369122.
Lichti CF, Mostovenko E, Wadsworth PA, Lynch GC, Pettitt BM, Sulman EP, Wang Q, Lang FF, Rezeli M, Marko-Varga G, Vegvari A, Nilsson CL. Systematic identification of single amino acid variants in glioma stem cell-derived chromosome 19 proteins. J Proteome Res 14(2):778-86, 2015. e-Pub 2015. PMID: 25399873.
Liu Q, Liu Y, Li W, Wang X, Sawaya R, Lang FF, Yung WK, Chen K, Fuller GN, Zhang W. Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma. Acta Neuropathol 130:587-97, 2015. e-Pub 2015. PMID: 26323991.
Wildburger NC, Zhou S, Zacharias LG, Kroes RA, Moskal JR, Schmidt M, Mirzaei P, Gumin J, Lang FF, Mechref Y, Nilsson CL. Integrated transcriptomic and glycomic profiling of glioma stem cell xenografts. J Proteome Res 14:3932-39, 2015. e-Pub 2015. PMID: 26185906.
Balasubramaniyan V, Vaillant B, Wang S, Gumin J, Butalid ME, Sai K, Mukheef F, Kim SH, Boddeke HW, Lang F, Aldape K, Sulman EP, Bhat KP, Colman H. Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting. Oncotarget 6:31007-17, 2015. e-Pub 2015. PMID: 26307681.
Sathyan P, Zinn P, Marisetty A, Liu B, Kamal M, Singh S, Bady P, Lu L, Wani K, Veo B, Gumin J, Kassem D, Robinson F, Weng C, Baladandayuthapani V, Suki D, Colman H, Bhat K, Sulman E, Aldape K, Colen R, Verhaak R, Lu Z, Fuller G, Huang S, Lang F, Sawaya R, Hegi M, Majumder S. Mir-21-Sox2 axis delineates glioblastoma subtypes with prognostic impact. J Neurosci 35:15097-112, 2015. e-Pub 2015. PMID: 26558781.
Gong AH, Wei P, Zhang S, Yao J, Yuan Y, Zhou A, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 drives a feed-forward STAT3 activation signaling loop that promotes the self-renewal and tumorigenicity of glioblastoma stem-like cells. Cancer Res 75:2337-48, 2015. e-Pub 2015. PMID: 25832656.
Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol 17:1463-73, 2015. e-Pub 2015. PMID: 25795306.
Grossberg A, Zhao Z, Walker G, Tsai J, Wang X, Lang F, Phan J, Ghia A, McGovern S, Mahajan A, Brown P, McAleer MF, Li J. Dose painting with gamma knife: two techniques for delivering different doses to areas of recurrent or residual tumor after resection of brain metastases. Pract Radiat Oncol 5:390-7, 2015. e-Pub 2015. PMID: 26412338.
Fahim DK, Tatsui CE, Suki D, Gumin J, Lang FF, Rhines LD. Orthotopic murine model of a primary malignant bone tumor in the spine: functional, bioluminescence and histological correlations. J Neurosurg Spine 21(3):378-85, 2014. e-Pub 2014. PMID: 24971476.
Lang FF, Barker FG. A history of the AANS/CNS Section on Tumors Biennial Satellite Symposium. J Neurooncol 119(3):593-600, 2014. e-Pub 2014. PMID: 25081975.
Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst 106(8):pii: dju162, 2014. e-Pub 2014. PMID: 24974128.
Jiang H, Clise-Dwyer K, Ruisaard KE, Fan X, Tian W, Gumin J, Lamfers ML, Kleijn A, Lang FF, Yung WK, Vence LM, Gomez-Manzano C, Fueyo J. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS One 9(5):e97407, 2014. e-Pub 2014.
Marko NF, Weil RJ, Schroeder J, Lang FF, Suki D, Sawaya R. Extent of resection of glioblastoma revisited: personalized survival modeling facilitates more accurate survival prediction and supports a "maximum safe resection" approach to surgery. J Clin Oncol 32(8):774-82, 2014. e-Pub 2014. PMID: 24516010.
Beiko J, Suki D, Hess KR, Fox B, Cheung V, Cabral M, Shonka N, Gilbert M, Sawaya R, Prabhu SS, Weinberg JS, Lang FF, Aldape K, Sulman EP, Rao G, McCutcheon IE, Cahill DP. IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro-Oncol 16(1):81-91, 2014. e-Pub 2014.
Beiko J, Suki D, Hess KR, Fox BD, Cheung V, Cabral M, Shonka N, Gilbert MR, Sawaya R, Prabhu SS, Weinberg J, Lang FF, Aldape KD, Sulman EP, Rao G, McCutcheon IE, Cahill DP. IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol 16(1):81-91, 2014. e-Pub 2014. PMID: 24305719.
Maldaun MVC, Khawja SN, Suki D, Levine NB, Rao G, Lang FF, Weinberg JS, Tummala S, Cowles CE, Ferson D, Nguyen AT, Sawaya R, Prabhu SS. Awake craniotomy for gliomas in a high-field (1.5T) intraoperative magnetic resonance operating room: analysis of 42 cases. J Neurosurgery 121(4):810-7, 2014. e-Pub 2014. PMID: 25105702.
Trinh VT, Fahim DK, Maldaun MVC, Shah K, McCutcheon IE, Rao G, Lang FF, Weinberg J, Sawaya R, Suki D, Prabhu SS. Impact of preoperative functional magnetic resonance imaging during awake craniotomy procedures for intraoperative guidance and complication avoidance. Stereotact Funct Neurosurg 92:315-322, 2014. e-Pub 2014.
Lichti CF, Liu H, Shavkunov AS, Mostovenko E, Sulman EP, Ezhilarasan R, Wang Q, Kroes RA, Moskal JC, Fenyö D, Oksuz BA, Conrad CA, Lang FF, Berven FS, Végvári A, Rezeli M, Marko-Varga G, Hober S, Nilsson CL. Integrated chromosome 19 transcriptomic and proteomic data sets derived from glioma cancer stem-cell lines. J Proteome Res 13(1):191-9, 2014. e-Pub 2014. PMID: 24266786.
Prashant Prasad G, Lang FF, Bruner JM, Ater JL, McCutcheon IE. Transsphenoidal removal of intrasellar pilocytic astrocytoma. J Clin Neurosci 21(6):1047-8, 2014. e-Pub 2014. PMID: 24308951.
Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D. A high Notch pathway activation predicts response to y secretase inhibitors in proneural subtype of glioma tumor initiating cells. Stem Cells 32:301-12, 2014. e-Pub 2014. PMID: 24038660.
Jiang H, Clise-Dwyer K, Ruisaard KE, Fan X, Tian W, Gumin J, Lamfers ML, Kleijn A, Lang FF, Yung WK, Vence LM, Gomez-Manzano C, Fueyo J. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS One 9(5):e97407, 2014. e-Pub 2014. PMID: 24827739.
Ghia AJ, Mahajan A, Allen PK, Armstrong TS, Lang FF, Gilbert MR, Brown PD. Supratentorial gross-totally resected non-anaplastic ependymoma: population-based patterns of care and outcomes analysis. J Neurooncol 115(3):513-20, 2013. e-Pub 2013. PMID: 24085643.
Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. Mesenchymal differentiation mediated by NF-kB promotes radiation resistance in glioblastoma. Cancer Cell 24(3):331-46, 2013. e-Pub 2013. PMID: 23993863.
Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, Yang Y, McEnery K, Jethwa K, Gjyshi O, Qiao W, Levine NB, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res 73(13):3913-26, 2013. e-Pub 2013. PMID: 23636127.
Kim YG, Jeon S, Sin GY, Shim JK, Kim BK, Shin HJ, Lee JH, Huh YM, Lee SJ, Kim EH, Park EK, Kim SH, Chang JH, Kim DS, Kim SH, Hong YK, Kang SG, Lang FF. Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens. Childs Nerv Syst 29(4):549-63, 2013. e-Pub 2013. PMID: 23274635.
Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. Alphavbeta 8 integrin interacts with rhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell 24(4):474-82, 2013. e-Pub 2013. PMID: 23283986.
Shinojima N, Hossain A, Takezaki T, Fueyo-Margareto J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu JI, Lang FF. TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res 73(7):2333-44, 2013. e-Pub 2013. PMID: 23365134.
Parker BC, Annala MJ, Cogdell DE, Granberg KJ, Sun Y, Ji P, Li X, Gumin J, Zheng H, Hu L, Yli-Harja O, Haapasalo H, Visakorpi T, Liu X, Liu CG, Sawaya R, Fuller GN, Chen K, Lang FF, Nykter M, Zhang W. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest 123(2):855-65, 2013. e-Pub 2013. PMID: 23298836.
Shin GY, Shim JK, Lee JH, Shin HJ, Lee SJ, Huh YM, Kim EH, Park EK, Kim SH, Chang JH, Kim DS, Hong YK, Kim SH, Kang SG, Lang FF. Changes in the biological characteristics of glioma cancer stem cells after serial in vivo subtransplantation. Childs Nerv Syst 29(1):55-64, 2013. e-Pub 2013. PMID: 23143001.
Kong BH, Park NR, Shim JK, Kim BK, Shin HJ, Lee JH, Huh YM, Lee SJ, Kim SH, Kim EH, Park EK, Chang JH, Kim DS, Kim SH, Hong YK, Kang SG, Lang FF. Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens. Childs Nerv Syst 29(2):217-29, 2013. e-Pub 2013. PMID: 23143002.
Nilsson CL, Berven F, Selheim F, Liu H, Moskal JR, Kroes RA, Sulman EP, Conrad CA, Lang FF, Andrén PE, Nilsson A, Carlsohn E, Lilja H, Malm J, Fenyö D, Subramaniyam D, Wang X, Gonzales-Gonzales M, Dasilva N, Diez P, Fuentes M, Végvári A, Sjödin K, Welinder C, Laurell T, Fehniger TE, Lindberg H, Rezeli M, Edula G, Hober S, Marko-Varga G. Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium. J Proteome Res 12(1):135-50, 2013. e-Pub 2013. PMID: 23249167.
Wu AS, Trinh VT, Suki D, Graham S, Forman A, Weinberg JS, McCutcheon IE, Prabhu SS, Heimberger AB, Sawaya R, Wang X, Qiao W, Hess K, Lang FF. A prospective randomized trial of peri-operative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg 118(4):873-83, 2013. e-Pub 2013. PMID: 23394340.
Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Yung WKA, Priebe W, Colman H. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol 107(3):487-501, 2012. e-Pub 2012. PMID: 22249692.
Kamal MM, Sathyan P, Singh SK, Zinn PO, Marisetty AL, Liang S, Gumin J, El-Mesallamy HO, Suki D, Colman H, Fuller GN, Lang FF, Majumder S. REST regulates oncogenic properties of glioblastoma stem cells. Stem Cells 30:405-14, 2012. e-Pub 2012. PMID: 22228704.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon I, Prabhu S, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape K, Sawaya R. Multiple craniotomies in the management of multifocal and multicentric glioblastoma. J Neurosurg 114(3):576-84, 2011. e-Pub 2011. PMID: 20690813.
Chern JJ, Tsung AJ, Humphries W, Sawaya R, Lang FF. Clinical outcome of leukemia patients with intracranial hemorrhage. J Neurosurg 115(2):268-72, 2011. e-Pub 2011. PMID: 21568656.
Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, LGnd F, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Hook M, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest 121(1):161-73, 2011. e-Pub 2011. PMID: 21183793.
Kim SM, Kang SG, Park NR, Mok HS, Huh YM, Lee SJ, Jeun SS, Hong YK, Park CK, Lang FF. Presence of glioma stroma mesenchymal stem cells in a murine orthotopic glioma model. Childs Nerv Syst 27(6):911-22, 2011. e-Pub 2011. PMID: 21298274.
Liu Y, Lang FF, Xie X, Prbhu SS, Xu J, Sampath D, Aldape K, Fuller G, Puduvalli VK. Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts. Cell Death Dis 2(1):e121, 2011. e-Pub 2011. PMID: 21368892.
Xu J, Sampath D, Lang FF, Prabhu S, Rao G, Fuller GN, Liu Y, Puduvalli VK. Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures. J Neurooncol 105(2):241-51, 2011. e-Pub 2011. PMID: 21598070.
Alonso MM, Diez-Valle R, Manterola L, Rubio A, Liu D, Cortes-Santiago N, Urquiza L, Jauregi P, deMunain AL, Sampron N, Aramburu A, Tejada-Solis S, Vicente C, Odero MD, Bandres E, Garcia-Foncillas J, Idoate MA, Lang FF, Fueyo J, Gomez-Manzano C. Genetic and epigenetic modifications of sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One 6(11):e26740, 2011. e-Pub 2011. PMID: 22069467.
Doucette T, Rao G, Yang Y, Gumin J, Shinojima N, Bekele BN, Qiao W, Zhang W, Lang FF. Mesenchymal stem cells display tumor specific tropism in an RCAS/Ntv-a glioma model. Neoplasia 13(8):716-25, 2011. e-Pub 2011. PMID: 21847363.
Wu AS, Witgert ME, Lang FF, Xiao L, Bekele BN, Meyers CA, Ferson D, Wefel JS. Neurocognitive function before and after surgery for insular gliomas. J Neurosurg 115(6):1115-25, 2011. e-Pub 2011. PMID: 21905800.
Bhat KP, Salazar KL, Balasubramaniyan V, Wani K, Heathcock L, Hollingsworth F, James JD, Gumin J, Diefes KL, Kim SH, Turski A, Azodi Y, Yang Y, Doucette T, Colman H, Sulman EP, Lang FF, Rao G, Copray S, Vaillant BD, Aldape KD. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev 25(24):2594-609, 2011. e-Pub 2011. PMID: 22190458.
Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin. Cancer Res 71(20):6371-81, 2011. e-Pub 2011. PMID: 21859829.
Hassaneen W, Suki D, Salaskar A, Wildrick DM, Lang FF, Fuller G, Sawaya R. Surgical management of lateral-ventricle metastases: report of 29 cases in a single-institution experience. J Neurosurg 112(5):1046-55, 2010. e-Pub 2010. PMID: 19663549.
He H, Nilsson CL, Emmett MR, Ji Y Marshall AG, Kroes RA, Moskal JR, Colman H, Lang FF, Conrad CA. Polar lipid remodeling and increased sulfatide expression are associated with the gliomas therapeutic candidates, wild type p53 elevation and the topoisomerase-1 inhibitor, Irinotecan. Glycoconj J 27(1):27-38, 2010. e-Pub 2010. PMID: 19557511.
Patel AJ, Suki D, Hatiboglu MA, Abouassi H, Shi W, Wildrick DM, Lang FF, Sawaya R. Factors influencing the risk of local recurrence after resection of a single brain metastasis. J Neurosurg 113(2):181-9, 2010. e-Pub 2010. PMID: 20035574.
Nilsson CL, Dillon R, Devakumar A, Shi SD, Greig M, Rogers JC, Krastins B, Rosenblatt M, Kilmer G, Major M, Kaboord BJ, Sarracino D, Rezai T, Prakash A, Lopez M, Ji Y, Priebe W, Lang FF, Colman H, Conrad CA. Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells. J Proteome Res 9(1):430-443, 2010. e-Pub 2010. PMID: 19899826.
Wu A, Aldape KD, Lang FF. High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors. J Neurooncol 99(1):57-64, 2010. e-Pub 2010. PMID: 20035368.
Hata N, Shinojima N, Gumin J, Yong R, Marini F, Andreeff M, Lang FF. Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas. Neurosurgery 66(1):144-156; discussion 156-157, 2010. e-Pub 2010. PMID: 20023545.
McPherson CM, Suki D, Feiz-Erfan I, Mahajan A, Chang E, Sawaya R, Lang FF. Adjuvant whole brain radiation therapy after surgical resection of single brain metastases. Neuro-Oncology 12(7):711-9, 2010. e-Pub 2010. PMID: 20156806.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther 9(1):67-78, 2010. e-Pub 2010. PMID: 20053772.
Nayar VV, Benveniste RJ, Lang FF. A novel technique for planning surgical approaches to the pineal region by using external cranial landmarks. J Neurosurg 113(5):1000-3, 2010. e-Pub 2010. PMID: 20397897.
He H, Nilsson CL, Emmett MR, Marshall AG, Kroes RA, Moskal JR, Ji Y, Colman H, Priebe W, Lang FF, Conrad CA. Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation. J Proteome Res 9(5):2098-108, 2010. e-Pub 2010. PMID: 20199106.
Kang S, Shinojima N, Hossain A, Gumin J, Yong R, Colman H, Marini F, Andreeff M, Lang FF. Isolation and perivascular localization of mesenchymal stem cells from mouse brain. Neurosurgery 67(3):711-20, 2010. e-Pub 2010. PMID: 20651630.
Hassaneen W, Suki D, Salaskar AL, Levine NB, DeMonte F, Lang FF, McCutcheon IE, Dorai Z, Feiz-Erfan I, Wildrick DM, Sawaya R. Immediate morbidity and mortality associated with transcallosal resection of tumors of the third ventricle. J Clin Neurosci 17(7):830-6, 2010. e-Pub 2010. PMID: 20478709.
Kumar AJ, Leeds NE, Kumar VA, Fuller GN, Lang FF, Milas Z, Weinberg JS, Ater JL, Sawaya R. Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. J Comput Assist Tomogr 34(4):601-11, 2010. e-Pub 2010. PMID: 20657231.
Wang W, Shao R, Wu Q, Ke S, McMurray J, Lang FF, Charnsangavej C, Gelovani JG, Li C. Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide. Mol Imaging Biol 11(6):424-433, 2009. e-Pub 2009. PMID: 19424760.
Martin V, Xu J, Pabbisetty SK, Alonso MM, Liu D, Lee OH, Gumin J, Bhat KP, Colman H, Lang FF, Fueyo J, Gomez-Manzano C. Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters. Oncogene 28(24):2358-2363, 2009. e-Pub 2009. PMID: 19421150.
Amano T, Nakamizo A, Mishra SK, Gumin J, Shinojima N, Sawaya R, Lang FF. Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes. J Neurooncol 92(3):357-71, 2009. e-Pub 2009. PMID: 19357962.
Kim SS, McCutcheon IE, Suki D, Weinberg JS, Sawaya R, Lang FF, Ferson D, Heimberger AB, DeMonte F, Prabhu SS. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery 64(5):836-46, 2009. e-Pub 2009. PMID: 19404147.
Yong R, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta-24-RGD to human gliomas. Cancer Res 69(23):8932-8940, 2009. e-Pub 2009. PMID: 19920199.
Tatsui CE, Lang FF, Gumin J, Suki D, Shinojima N, Rhines LD. An orthotopic murine model of human spinal metastasis: histological and functional correlations. J Neurosurg Spine 10(6):501-512, 2009. e-Pub 2009. PMID: 19558282.
Williams BJ, Suki D, Fox BD, Maldaun MVC, Sawaya RE, Lang FF, Rao G. Stereotactic radiosurgery for metastatic brain tumors: a comprehensive review of complications. J Neurosurg 111(3):439-448, 2009. e-Pub 2009. PMID: 19301968.
Jiang H, Gomez-Manzano C, Lang FF, Alemany R, Fueyo J. Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas. Curr Gene Ther 9(5):422-427, 2009. e-Pub 2009. PMID: 19860656.
Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth D, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole brain irradiation: a randomized controlled trial. (Reflection and reaction: focused attention on brain metastases. Knisely JPS). Lancet Oncol 10(11):1037-44, 2009. e-Pub 2009. PMID: 19801201.
McCord AM, Jamal M, Shankavarum UT, Lang FF, Camphausen K, Tofilon PJ. Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro. Mol Cancer Res 7(4):489-97, 2009. e-Pub 2009. PMID: 19372578.
Subbiah V, Huff V, Wolff JE, Ketonen L, Lang FF, Stewart J, Langford LA, Herzog CE. Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS 9 mutation: a 46 XY phenotypic female with Frasier Syndrome. Pediatr Blood Cancer 53(7):1349-1351, 2009. e-Pub 2009. PMID: 19653292.
Toms SA, Weil RJ, Gupta A, Boulis NM, Prayson R, Lang FF. Clinical problem solving: island intruder. Neurosurgery 62(4):920-8; discussion 928-9, 2008. e-Pub 2008. PMID: 18496198.
Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-93, 2008. e-Pub 2008. PMID: 18253154.
Xie TX, Aldape DK, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol 33(1):5-15, 2008. e-Pub 2008. PMID: 18575745.
Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol 10(3):275-291, 2008. e-Pub 2008. PMID: 18443131.
Dagnew E, Langford L, Lang FF, DeMonte F. Papillary tumors of the pineal region: case report. Neurosurgery 60(5):E953-5, 2007. e-Pub 2007. PMID: 17460510.
Chang SM, Vogelbaum M, Lang FF, Haines S, Kunwar S, Chiocca A, Olivi A, Quinones-Hinojosa A, Parsa A, Warnick R. GNOSIS: guidelines for neuro-oncology: standards for investigational studies - reporting of surgically based therapeutic clinical trials. J Neurooncol 82(2):211-20, 2007. e-Pub 2007.
Chang S, Vogelbaum M, Lang FF, Haines S, Kunwar S, Chiocca EA, Olivi A, Quinones-Hinojosa A, Parsa A, Warnick R. GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials. J Neurooncol 82(2):211-20, 2007. e-Pub 2007. PMID: 17146595.
Kunwar S, Prados MD, Chang SM, Berger MS, Lang FF, Piepmeier JM, Sampson JH, Ram Z, Gutin PH, Gibbons RD, Aldape KD, Croteau DJ, Sherman JW, Puri RK. Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the cintredekin besudotox intraparenchymal study group. J Clin Oncol 25(7):837-44, 2007. e-Pub 2007. PMID: 17327604.
Puchades M, Nilsson CL, Emmett MR, Aldape KD, Ji Y, Lang FF, Liu TJ, Conrad CA. Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytotoxic chemotherapy demonstrates an association between galectin-1 and p53 expression. J Proteome Res 6(2):869-75, 2007. e-Pub 2007. PMID: 17269744.
Alonso MM, Cascallo M, Gomez-Manzano C, Jiang H, Bekele BN, Perez-Gimenez A, Lang FF, Piao Y, Alemany R, Fueyo J. ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo. Cancer Res 67(17):8255-63, 2007. e-Pub 2007. PMID: 17804740.
Vogelbaum MA, Sampson JH, Kunwar S, Chang SM, Shaffrey M, Asher AL, Lang FF, Croteau D, Parker K, Grahn AY, Sherman JW, Husain SR, Puri RK. Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase I study of final safety results. Neurosurgery 61(5):1031-8, 2007. e-Pub 2007. PMID: 18091279.
Gilbert MR, Lang FF. Management of patients with low-grade gliomas. Neurol Clin 25(4):1073-88, 2007. e-Pub 2007. PMID: 17964026.
Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99(18):1410-4, 2007. e-Pub 2007. PMID: 17848677.
Chang EL, Wefel JS, Maor MH, Hassenbusch SJ, Mahajan A, Lang FF, Woo SY, Mathews LA, Allen PK, Shiu AS, Meyers CA. A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery 60(2):277-83, 2007. e-Pub 2007. PMID: 17290178.
Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM, Piao Y, Liu TJ, Lang FF, Bekele BN, Gomez-Manzano C. Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res 4(12):915-26, 2006. e-Pub 2006. PMID: 17189382.
Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF, Bekele BN, Zhou X, Alonso MA, Aldape KD, Fuller GN, Gomez-Manzano C. Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 8(5):419-28, 2006. e-Pub 2006. PMID: 16790091.
Leeds NE, Lang FF, Ribalta T, Sawaya R, Fuller GN. Origin of chordoid glioma of the third ventricle. Arch Pathol Lab Med 130(4):460-4, 2006. e-Pub 2006. PMID: 16594739.
Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 26(5):1666-78, 2006. e-Pub 2006. PMID: 16478988.
Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66(7):3593-602, 2006. e-Pub 2006. PMID: 16585184.
Ito H, Aoki H, Kuhnel F, Kondo Y, Kubicka S, Wirth T, Iwado E, Iwamaru A, Fujiwara K, Hess KR, Lang FF, Sawaya R, Kondo S. Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus. J Natl Cancer Inst 98(9):625-36, 2006. e-Pub 2006. PMID: 16670388.
Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res 12(2):556-62, 2006. e-Pub 2006. PMID: 16428500.
Conrad C, Miller CR, Ji Y, Gomez-Manzano C, Bharara S, McMurray JS, Lang FF, Wong F, Sawaya R, Yung WK, Fueyo J. Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization. Cancer Gene Ther 12:284-94, 2005. e-Pub 2005. PMID: 15650766.
Vecil GG, Suki D, Maldaun MV, Lang FF, Sawaya R. Resection of brain metastases previously treated with stereotactic radiosurgery. J Neurosurg 102(2):209-15, 2005. e-Pub 2005. PMID: 15739546.
Lang FF, Wildrick DM, DeMonte F, Sawaya R. Neurosurgical oncology at the University of Texas M. D. Anderson Cancer Center: its genesis and evolution. Neurosurgery 56(4):841-50, 2005. e-Pub 2005. PMID: 15792524.
Heimberger AB, Wang E, McGary EC, Hess KR, Henry VK, Shono T, Cohen Z, Gumin J, Sawaya R, Conrad CA, Lang FF. Mechanisms of action of rapamycin in gliomas. Neuro-oncol 7(1):1-11, 2005. e-Pub 2005. PMID: 15701277.
Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65(8):3307-18, 2005. e-Pub 2005. PMID: 15833864.
Vecil GG, Suki D, Maldaun MV, Lang FF, Sawaya R. Resection of brain metastases previously treated with stereotactic radiosurgery. J Neurosurg 102(2):209-15, 2005. e-Pub 2005.
Zhou YH, Wu X, Tan F, Shi YX, Glass T, Liu TJ, Wathen K, Hess KR, Gumin J, Lang F, Yung WK. PAX6 suppresses growth of human glioblastoma cells. J Neurooncol 71(3):223-9, 2005. e-Pub 2005. PMID: 15735909.
Fuller GN, Su X, Price RE, Cohen ZR, Lang FF, Sawaya R, Majumder S. Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol Cancer Ther 4(3):343-9, 2005. e-Pub 2005. PMID: 15767543.
Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Bekele BN, Yung WK, Fueyo J. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 23:1821-8, 2004. e-Pub 2004. PMID: 15014451.
Hanbali F, Tabrizi P, Lang FF, DeMonte F. Tumors of the skull base in children and adolescents. J Neurosurg (Pediatrics) 100:169-78, 2004. e-Pub 2004. PMID: 14758945.
Cohen ZR, Suki D, Weinberg JS, Marmor E, Lang FF, Gershenson DM, Sawaya R. Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome. J Neurooncol 66:313-25, 2004. e-Pub 2004. PMID: 15015663.
Cerrato JA, Khan T, Koul D, Lang FF, Conrad CA, Yung WK, Liu TJ. Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas. Int J Oncol 24:409-17, 2004. e-Pub 2004. PMID: 14719118.
Selek U, Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys 59(4):1097-106, 2004. e-Pub 2004. PMID: 15234044.
Watanabe Y, Kameoka S, Gopalakrishnan V, Aldape KD, Pan ZZ, Lang FF, Majumder S. Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev 18(8):889-900, 2004. e-Pub 2004. PMID: 15078815.
Maldaun MV, Suki D, Lang FF, Prabhu S, Shi W, Fuller GN, Wildrick DM, Sawaya R. Cystic glioblastoma multiforme: survival outcomes in 22 cases. J Neurosurg 100:61-7, 2004. e-Pub 2004. PMID: 14743913.
Song SW, Fuller GN, Khan A, Kong S, Shen W, Taylor E, Ramdas L, Lang FF, Zhang W. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. Proc Natl Acad Sci U S A 100:13970-5, 2003. e-Pub 2003. PMID: 14617774.
Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen PK, Sawaya R, Maor MH. The role of tumor size in the radiosurgical management of patients with ambiguous brain metastases. Neurosurgery 53:272-80, 2003. e-Pub 2003. PMID: 12925241.
Lang FF, Bruner JM, Fuller GN, Aldape K, Prados MD, Chang S, Berger MS, McDermott MW, Kunwar SM, Junck LR, Chandler W, Zwiebel JA, Kaplan RS, Yung WK. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J Clin Oncol 21:2508-18, 2003. e-Pub 2003. PMID: 12839017.
Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, Lemoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst 95:652-60, 2003. e-Pub 2003. PMID: 12734316.
Lang FF, Gilbert MR, Puduvalli VK, Weinberg J, Levin VA, Yung WK, Sawaya R, Fuller GN, Conrad CA. Toward better early-phase brain tumor clinical trials: a reappraisal of current methods and proposals for future strategies. Neuro Oncol 4(4):268-77, 2002. e-Pub 2002. PMID: 12356357.
Parker BC, Shiu AS, Maor MH, Lang FF, Liu HH, White RA, Antolak JA. PTV margin determination in conformal SRT of intracranial lesions. J Appl Clin Med Phys 3(3):176-89, 2002. e-Pub 2002. PMID: 12132939.
Russell JS, Raju U, Gumin GJ, Lang FF, Wilson DR, Huet T, Tofilon PJ. Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. Cancer Res 62(8):2318-26, 2002. e-Pub 2002. PMID: 11956090.
Shono T, Tofilon PJ, Schaefer TS, Parikh D, Liu TJ, Lang FF. Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 62(4):1069-76, 2002. e-Pub 2002. PMID: 11861384.
Billingsley RL, Lang FF, Slopis JM, Schrimsher GW, Ater JL, Moore BD. Visual-spatial neglect in a child following sub-cortical tumor resection. Dev Med Child Neurol 44(3):191-9, 2002. e-Pub 2002. PMID: 12008674.
Michael CB, Gokaslan ZL, DeMonte F, McCutcheon IE, Sawaya R, Lang FF. Surgical resection of calvarial metastases overlying dural sinuses. Neurosurgery 48(4):745-55, 2001. e-Pub 2001. PMID: 11322434.
Wang S, Khan A, Lang FF, Schaefer TS. Conditional gene expression in human intracranial xenograft tumors. Biotechniques 31(1):196-202, 2001. e-Pub 2001. PMID: 11464512.
Lang FF, Olansen NE, DeMonte F, Gokaslan ZL, Holland EC, Kalhorn C, Sawaya R. Surgical resection of intrinsic insular tumors: complication avoidance. J Neurosurg 95(4):638-50, 2001. e-Pub 2001. PMID: 11596959.
Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):190-8, 2001. e-Pub 2001. PMID: 11780887.
Jackson RJ, Fuller GN, Abi-Said D, Lang FF, Gokaslan ZL, Shi WM, Wildrick DM, Sawaya R. Limitations of stereotactic biopsy in the initial management of gliomas. Neuro Oncol 3(3):193-200, 2001. e-Pub 2001. PMID: 11465400.
Fourney DR, Abi-Said D, Rhines LD, Walsh GL, Lang FF, McCutcheon IE, Gokaslan ZL. Simultaneous anterior-posterior approach to the thoracic and lumbar spine for the radical resection of tumors followed by reconstruction and stabilization. J Neurosurg (Spine 2) 94(Suppl 2):232-44, 2001. e-Pub 2001. PMID: 11302626.
Fourney DR, Abi-Said D, Lang FF, McCutcheon IE, Gokaslan ZL. Use of pedicle screw fixation in the management of malignant spinal disease: experience in 100 consecutive procedures. J Neurosurg Spine 94(Suppl 1):25-37, 2001. e-Pub 2001. PMID: 11147865.
Shono T, Tofilon PJ, Bruner JM, Owolabi O, Lang FF. Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. Cancer Res 61(11):4375-81, 2001. e-Pub 2001. PMID: 11389063.
Srivenugopal KS, Shou J, Mullapudi SR, Lang FF, Jr, Rao JS, Ali-Osman F. Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clin Cancer Res 7(5):1398-409, 2001. e-Pub 2001. PMID: 11350911.
Lal S, Lacroix M, Tofilon P, Fuller GN, Sawaya R, Lang FF. An implantable guide-screw system for brain tumor studies in small animals. J Neurosurg 92(2):326-33, 2000. e-Pub 2000. PMID: 10659021.
Petersen C, Petersen S, Milas L, Lang FF, Tofilon PJ. Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. Clin Cancer Res 6(6):2513-20, 2000. e-Pub 2000. PMID: 10873107.
Maor MH, Dubey P, Tucker SL, Shiu AS, Mathur BN, Sawaya R, Lang FF, Hassenbusch SJ. Stereotactic radiosurgery for brain metastases: results and prognostic factors. Int J Cancer (Radiat Oncol Invest) 90(3):157-62, 2000. e-Pub 2000. PMID: 10900428.
Miller DJ, Lang FF, Walsh GL, Abi-Said D, Wildrick DM, Gokaslan ZL. Coaxial double-lumen methylmethacrylate reconstruction in the anterior cervical and upper thoracic spine after tumor resection. J Neurosurg (Spine) 92(Suppl 2):181-90, 2000. e-Pub 2000. PMID: 10763689.
Russell JS, Lang FF, Huet T, Janicot M, Chada S, Wilson DR, Tofilon PJ. Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment. Cancer Res 59(20):5239-44, 1999. e-Pub 1999. PMID: 10537303.
York JE, Walsh GL, Lang FF, Putnam JB, McCutcheon IE, Swisher SG, Komaki R, Gokaslan ZL. Combined chest wall resection with vertebrectomy and spinal reconstruction for the treatment of pancoast tumors. J Neurosurg (Spine 1) 91(Suppl 1):74-80, 1999. e-Pub 1999. PMID: 10419372.
Ginsberg LE, Lang FF. Neuroradiologic screening for brain metastases--can quadruple dose gadolinium be far behind?. AJNR Am J Neuroradiol 19(5):829-30, 1998. e-Pub 1998. PMID: 9613495.
Lang FF, Wildrick DM, Sawaya R. Management of Cerebral Metastases: The Role of Surgery. Cancer Control 5(2):124-129, 1998. e-Pub 1998. PMID: 10761023.
Lang FF, Yung WK, Raju U, Libunao F, Terry NH, Tofilon PJ. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. J Neurosurg 89(1):125-32, 1998. e-Pub 1998. PMID: 9647183.
Gokaslan ZL, York JE, Walsh GL, McCutcheon IE, Lang FF, Putnam JB, Jr, Wildrick DM, Swisher SG, Abi-Said D, Sawaya R. Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 89(4):599-609, 1998. e-Pub 1998. PMID: 9761054.
Lang FF, Miller DC, Koslow M, Newcomb EW. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 81(3):427-36, 1994. e-Pub 1994. PMID: 8057151.
Lang FF, Deletis V, Cohen HW, Velasquez L, Abbott R. Inclusion of the S2 dorsal rootlets in functional posterior rhizotomy for spasticity in children with cerebral palsy. Neurosurgery 34(5):847-53, 1994. e-Pub 1994. PMID: 8052381.
Lang FF, Miller DC, Pisharody S, Koslow M, Newcomb EW. High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 9(3):949-54, 1994. e-Pub 1994. PMID: 8108140.
Miller DC, Lang FF, Epstein FJ. Central nervous system gangliogliomas. Part 1: Pathology. J Neurosurg 79(6):859-66, 1993. e-Pub 1993. PMID: 8246054.
Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC. Central nervous system gangliogliomas. Part 2: Clinical outcome. J Neurosurg 79(6):867-73, 1993. e-Pub 1993. PMID: 8246055.
Newcomb EW, Madonia WJ, Pisharody S, Lang FF, Koslow M, Miller DC. A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme. Brain Pathol 3(3):229-35, 1993. e-Pub 1993. PMID: 8293182.
Recio-Pinto E, Lang FF, Ishii DN. Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells. Proc Natl Acad Sci U S A 81(8):2562-6, 1984. e-Pub 1984. PMID: 6326132.

Invited Articles

Suki D, Lang FF, Maldaun MVC, Abouassi H, Chang EL, de Aguiar PHP, Sawaya R. Complications of stereotactic radiosurgery in patients with brain metastases: considerations for deep and functional brain tumor locations. Neurosurg Q 17(2):81-91, 2007. e-Pub 2007.
Gilbert MR, Lang FF. Should patients with anaplastic oligodendroglial tumors receive adjuvant chemotherapy. Nat Clin Pract Neurol 3(1):14-5, 2007. e-Pub 2007. PMID: 17205067.
Gilbert MR, Lang FF. Anaplastic oligodendroglial tumors: a tale of two trials. J Clin Oncol 24(18):2689-90, 2006. e-Pub 2006.
Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. Oncolytic adenoviruses as antiglioma agents. Expert Rev Anticancer Ther 6(5):697-708, 2006. e-Pub 2006. PMID: 16759161.
Lawrence TS, Buckner JC, Lang FF. CNS malignancies: at last, real progress. J Clin Oncol 24(8):1225-7, 2006. e-Pub 2006.
Lang FF, Yung WKA. In reply. J Clin Oncol 22(7):1345, 2004. e-Pub 2004.
Lang FF, Sawaya R. Surgical treatment of metastatic brain tumors. Semin Surg Oncol 14(1):53-63, 1998. e-Pub 1998.
Lang FF, Wildrick DM, Sawaya R. Management of cerebral metastases: the role of surgery. Cancer Control: J Moffitt Cancer Center 5(2):124-9, 1998. e-Pub 1998.
Lang FF, Sawaya R. Current controversies in the surgical management of cerebral metastasis. Perspect Neurol Surg 7:55-70, 1997. e-Pub 1997.
Lang FF, Sawaya R. Strategies in surgical management of metastatic brain tumors. M.D. Anderson Oncology Cancer Reports and Reviews 12:1-10, 1997. e-Pub 1997.
Lang FF, Sawaya R. Surgical management of cerebral metastases. Neurosurg Clin N Am 7:459-84, 1996. e-Pub 1996.

Review Articles

Garcia-Moure M, Laspidea V, Gupta S, Gillard AG, Khatua S, Parthasarathy A, He J, Lang FF, Fueyo J, Alonso MM, Gomez-Manzano C. The emerging field of viroimmunotherapy for pediatric brain tumors. Neuro Oncol 26(11):1981-1993, 2024. e-Pub 2024. PMID: 39148489.
Young CC, Kan P, Chen SR, Lang FF. Endovascular surgical neuro-oncology: advancing a new subspecialty. J Neurooncol 170(1):31-40, 2024. e-Pub 2024. PMID: 39222190.
Hasanov E, Yeboa DN, Tucker MD, Swanson TA, Beckham TH, Rini B, Ene CI, Hasanov M, Derks S, Smits M, Dudani S, Heng DYC, Brastianos PK, Bex A, Hanalioglu S, Weinberg JS, Hirsch L, Carlo MI, Aizer A, Brown PD, Bilen MA, Chang EL, Jaboin J, Brugarolas J, Choueiri TK, Atkins MB, McGregor BA, Halasz LM, Patel TR, Soltys SG, McDermott DF, Elder JB, Baskaya MK, Yu JB, Timmerman R, Kim MM, Mut M, Markert J, Beal K, Tannir NM, Samandouras G, Lang FF, Giles R, Jonasch E. An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma. CA Cancer J Clin 72(5):454-489, 2022. e-Pub 2022. PMID: 35708940.
Srinivasan VM, Ene C, Kerrigan BP, Lang FF. Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors. Neurosurg Clin N Am 32(1):93-104, 2021. e-Pub 2021. PMID: 33223031.
Jiang W, Wang Y, Wargo JA, Lang FF, Kim BYS. Considerations for designing preclinical cancer immune nanomedicine studies. Nat Nanotechnol 16(1):6-15, 2021. e-Pub 2021. PMID: 33349682.
Srinivasan VM, Lang FF, Chen SR, Chen MM, Gumin J, Johnson J, Burkhardt JK, Kan P. Advances in endovascular neuro-oncology: endovascular selective intra-arterial (ESIA) infusion of targeted biologic therapy for brain tumors. J Neurointerv Surg 12(197-203):197-203, 2020. e-Pub 2020. PMID: 31676690.
Privorotskiy A, Bhavsar SP, Lang FF, Hu J, Cata JP. Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review. Neurooncol Adv 2(1):vdaa123, 2020. e-Pub 2020. PMID: 33205044.
Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, Weygand J, Dutta P, Pudakalakatti S, Millward NZ, Gammon ST, Lang FF, Heimberger AB, Bhattacharya PK. Interrogating Metabolism in Brain Cancer. Magn Reson Imaging Clin N Am 24(4):687-703, 2016. e-Pub 2016. PMID: 27742110.
Maldaun MV, Aguiar PH, Lang F, Suki D, Wildrick D, Sawaya R. Radiosurgery in the treatment of brain metastases: critical review regarding complications. Neurosurg Rev 31(1):1-8; discussion 8-9, 2008. e-Pub 2008. PMID: 17957397.
Lang FF, Gilbert MR. Diffusely infiltrative low-grade gliomas in adults. J Clin Oncol 24(8):1236-45, 2006. e-Pub 2006. PMID: 16525178.
Hentschel SJ, Lang FF. Surgical resection of intrinsic insular tumors: operative nuances. Neurosurgery 57:176-83, 2005. e-Pub 2005. PMID: 15987586.
Hentschel SJ, Yen KG, Lang FF. Chiari I malformation and acute acquired comitant esotropia: case report and review of the literature. J Neurosurg 102(Suppl 4):407-12, 2005. e-Pub 2005. PMID: 15926393.
Shaffrey ME, Mut M, Asher AL, Burri SH, Chahlavi A, Chang SM, Farace E, Fiveash JB, Lang FF, Lopes MB, Markert JM, Schiff D, Siomin V, Tatter SB, Vogelbaum MA. Brain metastases. Curr Probl Surg 41(8):665-741, 2004. e-Pub 2004. PMID: 15354117.
Lang FF, Asher A. Prospective clinical trials of brain tumor therapy: the critical role of neurosurgeons. J Neurooncol 69(1-3):151-67, 2004. e-Pub 2004. PMID: 15527087.
Vecil GG, Lang FF. Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses. J Neurooncol 65:237-46, 2003. e-Pub 2003. PMID: 14682374.
Vecil GG, Lang FF. Surgical resection of metastatic intraventricular tumors. Neurosurg Clin N Am 14:593-606, 2003. e-Pub 2003. PMID: 15024803.
Hentschel SJ, Lang FF. Current surgical management of glioblastoma. Cancer J 9(2):113-25, 2003. e-Pub 2003. PMID: 12784877.
Raza SM, Lang FF, Aggarwal BB, Fuller GN, Wildrick DM, Sawaya R. Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis. Neurosurgery 51(1):2-12, 2002. e-Pub 2002. PMID: 12182418.
Weinberg JS, Lang FF, Sawaya R. Surgical management of brain metastases. Curr Oncol Rep 3(6):476-83, 2001. e-Pub 2001. PMID: 11595115.
Lang FF, Macdonald OK, Fuller GN, DeMonte F. Primary extradural meningiomas: a report on nine cases and review of the literature from the era of computerized tomography scanning. J Neurosurg 93(6):940-50, 2000. e-Pub 2000. PMID: 11117866.
Lang FF, Yung WK, Sawaya R, Tofilon PJ. Adenovirus-mediated p53 gene therapy for human gliomas. Neurosurgery 45(5):1093-104, 1999. e-Pub 1999. PMID: 10549925.
Lang FF, Sawaya R. Surgical treatment of metastatic brain tumors. Semin Surg Oncol 14(1):53-63, 1998. e-Pub 1998. PMID: 9407631.
Lang FF, Sawaya R. Surgical management of cerebral metastases. Neurosurg Clin N Am 7(3):459-84, 1996. e-Pub 1996. PMID: 8823775.

Professional Educational Materials

Lang FF. Society for Neuro-Oncology Annual Report, 2010.
Lang FF, Guha A, Puduvalli V. Society for Neuro-Oncology 15th Anniversary Brochure, 2010.
Lang FF. International Research Fellowship Begins Another Round of Funding, Tumor News, AANS/CNS Section on Tumors Newsletter, Fall, 2008.
Lang FF. "Tumor Section/BrainLAB International Research Fellowship Awarded", Tumor News, AANS/CNS Section on Tumors Newsletter, Spring, 2008.
Lang FF. "Section on Tumors/BrainLAB International Research Fellowship Enters Second Funding Cycle". AANS/CNS Section on Tumors Newsletter, Fall, 2007.
Lang FF. "First Section on Tumors/BrainLAB International Research Fellowship Awarded". AANS/CNS Section on Tumors Newsletter, Spring, 2007.
Gilbert MR, Lang FF, Woo S, Armstrong TS. "Case Studies in Newly Diagnosed GBM". M.D. Anderson Cancer Center/Schering-Plough Corporation for Temodar Educational Patient Brochure, 2006.
Lang FF. "Section on Tumors Establishes New International Research Fellowship". AANS/CNS Section on Tumors Newsletter, Fall, 2006.
Lang FF. "Sixth Biennial Tumor Satellite Symposium". AANS/CNS Section on Tumors Newsletter, Spring, 2005.

Editorials

Lang FF. (Comments) RE: Mohammadi AM, Sullivan TB, Barnett GH, Recinos V, Angelov L, Kamian K, Vogelbaum MA. Use of high-field intraoperative magnetic resonance imaging to enhance the extent of resection of enhancing and nonenhancing gliomas. Neurosurgery 74:339-50, 2014.
Lang FF. (Comments: 325-6) RE: Kourbeti IS, Jacobs AV, Koslow M, Karabetsos D, Holzman RS. Risk factors associated with postcraniotomy meningitis. Neurosurgery 60(2):317-25; discussion 325-6, 2007.
Gilbert MR, Lang FF. Anaplastic oligodendroglial tumors: a tale of two trials. J Clin Oncol 24(18):2689-90, 2006. PMID: 16782906.
Lang FF, Sawaya R. (Comments) RE: Brain metastasis in patients with sarcoma: an analysis of histological subtypes, clinical characteristics, and outcomes. Surg Neurol 54(2):164, 2000.
Lang FF, Sawaya R. (Comments) RE: Mycosis fungoides metastasizing to the brain parenchyma: case report. Neurosurgery 42(4):933-7, 1998.
Ginsberg LE, Lang FF. Neuroradiologic screening for brain metastases - Can quadruple dose gadolinium be far behind. Am J Neuroradiol 19:829-30, 1998.
Lang FF, Sawaya R. Effect of implant dose/volume and surgical resection on survival in a rat glioma brachytherapy model: implications for brain tumor therapy. Neurosurgery 41:1374-84, 1997.

Abstracts

Bronk JK, Bronk LF, Singh S, Guan F, Wang X, Zhu R, Schueler E, Jiang D, Mohan R, Koong AC, Lang FF, Grosshans DR. Radio-protective effects of ultra-high dose rate proton radiation (FLASH-RT) in a human induced pluripotent stem cell-derived cerebral organoid model. 104th American Radium Society Annual Meeting, Phoenix, AZ, May 19-22, 2022. e-Pub 2022.
Lang FF. Efficacy of EGFR/PI3K signaling inhibition is enhanced with LSD1 inhibition in glioblastoma stem cell (GSC) models. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Jiang H, Lang FF. Combining oncolytic adenovirus Delta-24-RGDOX with adoptive T cell therapy in localized treatment induces sustainable regression of disseminated solid tumors through antigen spreading. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Nguyen T, Lang FF. RNA-seq analyses reveal remodeling of tumor microenvironment and reversal of glioma resistance to oncolytic viruses by targeting immunometabolism. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Shin DH, Lang FF. Redirection of anti-virus immunity towards anti-tumor immunity using nanoparticle-induced immune tolerance for oncolytic adenovirus therapy. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Abdelfattah N, Lang FF. A multi-dimensional analysis of human gliomas at the single cell level identifies immune suppressive macrophage molecular signatures and a novel immunotherapy target for GBM. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Gupta S, Laspidea V, Fueyo J, Zaky W, Becher O, Nguyen T, Shin DH, Jiang H, Sohoni S, Fan X, Yi Y, Gumin J, Lang FF, Gomez-Manzano C, Alonso MM. Armed Oncolytic Adenovirus as Experimental Therapy for Pediatric Malignant Gliomas. 2022 American Society of Pediatric Hematology Oncology, Pittsburgh, PA, May 4-7, 2022. e-Pub 2022.
Van Wieren AC, Sohoni S, Nguyen T, Ossimetha A, Rivera-Molina Y, Jiang H, Shin DH, Kim D, Fan X, Yi Y, Melendez-Vazquez NM, Godoy-Vitorino F, Gumin J, Lang FF, Alonso MM, Fueyo J, Gomez-Manzano C. Viroimmunotherapy for solid tumors results in local and abscopal anti-cancer effects and the remodeling of tumor microenvironment. American Association for Cancer Research Annual Meeting, New Orleans, LA, April 8-13, 2022. e-Pub 2022.
Stitzlein L, Espejo AB, Gangadharan A, Sulman EP, Lang FF, Chandra J, Gumin J, Grasse L, Singh MM, Ezhilarasan R, Schneider R, Lu Y. Evaluation of in vitro and in vivo efficacy of pharmacological lysine-specific demethylase 1 (LSD1) inhibitors in glioblastoma stem cell (GSC) models. Experimental Biology 2022, Philadelphia, PA, April 2-5, 2022. e-Pub 2022.
Gupta S, Laspidea V, Fueyo J, Becher O, Nguyen T, Shin DH, Jiang H, Sohoni S, Fan X, Yi Y, Gumin J, Lang FF, Gomez-Manzano C, Alonso MM. Viroimmunotherapy for diffuse intrinsic pontine gliomas. American Society of Pediatric Hematology/Oncology Conference, Virtual Meeting, April 21-24, 2021. e-Pub 2021.
Hasanov M, Milton DR, Davies A, Sirmans E, Saberian C, Posada E, Gershenwald JE, Torres-Cabala CA, Huse JT, Tawbi HA, Glitza IC, Li J, Chung C, Yeboa DN, Opusunju S, Kim BYS, Lang FF, Haydu LE, Davies MA, Ferguson SD. Predictors of Overall Survival (OS) in Patients (Pts) with Melanoma Brain Metastasis (MBM) in the Past and Modern Era. The 18th International Congress of the Society for Melanoma Research, Virtual, October 28-31, 2021. e-Pub 2021.
Hasanov M, Milton DR, Davies A, Sirmans E, Saberian C, Posada E, Gershenwald JE, Torres-Cabala CA, Huse JT, Tawbi HA, Glitza IC, Li J, Chung C, Yeboa DN, Opusunju S, Kim BYS, Lang FF, Haydu LE, Davies MA, Ferguson SD. Predictors of overall survival (OS) in patients (Pts) with melanoma brain metastasis (MBM) in the modern era. American Society of Clinical Oncology, Virtual Meeting, June 4-8, 2021. e-Pub 2021.
Salzillo T, Gumin J, Lee J, Millward NZ, Gammon ST, Lang FF, Bhattacharya P. Predicting glioblastoma recurrence with hyperpolarized magnetic resonance. World Molecular Imaging Congress 2021 Meeting, Miami, FL, October 6-9, 2021. e-Pub 2021.
Haider AS, Ene C, Fuller GN, Schomer DF, Gule-Monroe MK, DeMonte F, Ferguson SD, Lang FF, McCutcheon I, Prabhu S, Raza SM, Suki D, Weinberg JS, Sawaya R. 4th Ventricle Subependymoma: To operate or not to operate?. Congress of Neurological Surgeons Annual Meeting, Austin, TX, October 16-20, 2021. e-Pub 2021.
Singh S, Munyeshyaka M, Gumin J, Yang J, Ledbetter D, Hossain A, Kerrigan BP, Lang FF. Behavior of glioblastoma stem-like cells with known IDH1 Status in cerebral organoids. Society for Neuro-Oncology Virtual Annual Meeting, November 19 - 21, 2020. e-Pub 2020.
Bronk L, Singh S, Thomas R, Parkitny L, Maletic-Savatic M, Mohan R, Lang FF, Grosshans D. Implementation of human induced pluripotent stem cell derived cerebral organoids to model normal tissue radio response. Society for Neuro-Oncology Virtual Annual Meeting, November 19 - 21, 2020. e-Pub 2020.
Lang FF, McDonald MF, Hossain A. Enhanced exosomes and microRNA cocktails in the treatment of glioblastoma. American Academy of Neurological Surgery, Virtual Meeting, September 26, 2020. e-Pub 2020.
Gopakumar S, Gumin J, Daou M, Ledbetter D, McDonald M, Hossain A, Hingtgen S, Ewend M, Lang F. Stem cell delivery of oncolytic adenovirus DNX-2401 following surgical resection for the treatment of glioblastoma. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
McDonald M, Hasan I, Adachi S, Gumin J, Ledbetter D, Daou M, Gopakumar S, Momin E, Long L, Phillips L, Parker Kerrigan B, Hossain A, Lang F. Engineered exosomes for therapeutic gene delivery in brain tumors. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Rivera-Molina Y, Fueyo J, Jiang H, Nguyen T, Shin DO, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang F, Gomez-Manzano C. Activating the immunity within the tumor using viroimmunotherapy: Delta-24-RGD oncolytic adenovirus armed with the immunopositive regulator GITRL. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Jiang H, Shin DH, Nguyen T, Alonso MM, Lang F, Gomez-Manzano C, Fueyo J. Treatment with Delta-24-RGDOX of subcutaneous tumors results in abscopal effect eradicating intracranial melanomas. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Aiken R, Aiken R, Chen C, Chen C, Cloughesy T, Cloughesy T, Colman H, Colman H, Daras M, Daras M, Groves M, Groves M, Khagi S, Khagi S, Kumthekar P, Kumthekar P, Lang F, Lang F, Nassiri F, Nassiri F, Ong S, Ong S, Ramakrishna R, Ramakrishna R, Sonabend A, Sonabend A, Vogelbaum M, Vogelbaum M, Zadeh G, Zadeh G, Agensky L, Agensky L, Bidwell C, Bidwell C, Watkins B, Watkins B, Tufaro F, Tufaro F, Peterkin J, Peterkin J. Interim results pf a [hase II multi-center study of oncolytic adenovirus DNX-2401 with Pembrolizumab for recurrent glioblastoma. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Salzillo T, Gumin J, Lee J, Hassan I, Millward NZ, Colen R, Lang F, Bhattacharya P. Imaging the metabolic evolution of patient-derived glioblastoma xenografts in vivo with hyperpolarized magnetic resonance during tumor development and following radiation therapy. 12th Annual World Molecular Imaging Congress (WMIC), Montreal, Quebec, September 4-7, 2019. e-Pub 2019.
Nguyen T, Shin DH, Jiang H, Lang F, Gomez-Manzano C, Fueyo J. Combined IDO inhibitor and OX40L-armed-oncolytic-adenovirus therapy improves survival in murine glioblastoma. American Association for Cancer Research Tumor Immunology & Immunotherapy Annual Meeting, Boston, MA, November 17-20, 2019. e-Pub 2019.
Kassab C, Zamler D, Gupta P, Srinivasan V, Rao G, Prabhu S, Huse J, Fuller G, Bruner J, Langford L, McCutcheon I, Ferguson S, Weinberg J, Wistuba I, Lang F, Bhat K, Heimberger A. Comprehensive spatial characterization of immune cells in the CNS brain tumor microenvironment. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Hossain A, Hasan I, Adachi S, Ledbetter D, McDonald M, Gumin J, Daou M, Phillips L, Parker Kerrigan B, Lang F. Intercellular communication between normal and tumor cells in glioma microenvironment. Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, November 21-24, 2019. e-Pub 2019.
Hossain A, Hasan I, Adachi S, Gumin J, Kerrigan B, Lang F. Engineered exosomes for glioma therapy. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Jiang H, Nguyen T, Shi DH, Fan X, Gumin J, Bernatchez C, Lang F, Gomez-Manzano C, Fueyo J. In situ autovaccination mediated by oncolytic adenovirus Delta-24-RGDOX induces efficacious immunity against metastatic melanoma. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Phillips L, Li S, Gumin J, Ledbetter D, Hossain A, Kerrigan B, Gomez-Manzano C, Fueyo J, Lang F. A novel adenoviral-permissive, immunocompetent hamster model to evaluate oncolytic adenoviral therapy for glioblastoma. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Ott M, Zhou S, Wei J, de Groot J, Huse JT, McCutcheon I, Prabhu S, Ferguson S, Weinberg J, Sawaya R, Rao G, Lang F, Heimberger A. Glioma immune profiling reveals unique immune therapeutic opportunities. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Jiang H, Nguyen T, Shi DH, Fan X, Gumin J, Bernatchez C, Lang F, Gomez-Manzano C, Fueyo J. Delta-24-RGDOX induces efficacious immunity against metastatic melanoma. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Hasan I, Momin E, Gumin J, Adachi S, Kerrigan B, Hossain A, Lang F. MSC-derived exosomes and microRNA in glioma therapy. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Hassan I, Singh S, Mosley J, Elshafeey N, Kotrotsou A, Lang F, Zinn P, Colen R. Early detection of tumor cell proliferation is associated with a unique radiomic biomarker in preclinical glioblastoma xenograft and patients. Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Zadeh G, Lang F, Daras M, Cloughesy T, Colman H, Ong S, Ramakrishna R, Vogelbaum M, Groves M, Nassiri F, Frederick LS, Gammon K, Fulling S, Rowland KA, Mitchell E, Ewald B, Tufaro F, Peterkin J. Interim results of a phase II multicenter study of the conditionally replicative oncolytic adenovirus DNX-2401 with pembrolizumab (Keytruda) for recurrent glioblastoma; Captive Study (Keynote 192). Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Nguyen T, Rivera-Molina Y, Puerta Martinez F, Fan X, Henry V, Jiang H, Lang F, Fueyo J, Gomez-Manzano C. Inflammatory reprogramming of gliomas using Delta-24-RGDOX and immunometabolic adjuvants. 23rd Annual Meeting and Education Day of the Society for Neuro-Oncology, New Orleans, LA, November 15-18, 2018. e-Pub 2018.
Zinn PO, Singh SK, Kotrotsou A, Hassan I, Luedi MM, Thomas G, Elshafeey N, Mosley J, Elakkad A, Idris T, Gumin J, Fuller GN, de Groot J, Baladandayuthapani V, Sulman EP, Kumar AM, Sawaya R, Lang FF, Piwnica-Worms D, Colen RR. Toward the co-clinical glioblastoma treatment paradigm – radiomic machine learning identifies glioblastoma gene expression in patients and corresponding xenograft tumor models. Congress of Neurological Surgeons Annual Meeting, Houston, TX, October 6-10. *Won CNS Resident Award, 2018. e-Pub 2018.
Al-Holou WJ, Suki D, Sawaya R, Lang FF. Low grade gliomas: use of a circumferential en bloc resection technique results in improved outcomes. Congress of Neurological Surgeons Annual Meeting, Houston, TX, October 6-10, 2018. e-Pub 2018.
Zinn P, Luedi M, Singh S, Mosley J, Hassan I, Hatami M, Gumin J, Andereggen L, Sulman E, Lang F, Stueber F, Fuller G, Colen R. Dexamethasone induces mesenchymal trans-differentiation and promotes hallmarks of cancer in glioblastoma. Congress of Neurological Surgeons Annual Meeting, Boston, MA, October 7-11, 2017. e-Pub 2017.
Wang X, Rao G, Li J, McAleer M, McGovern S, Ghia A, Sulman E, Brown P, Ferguson S, Heimberger A, Lang F, McCutcheon I, Prabhu S, Sawaya R, Weinberg J, Ahmed S, Luo D, Mahajan A. Pattern of failure after resection followed by gamma knife radiosurgery to the surgical cavity. 13th International Stereotactic Radiosurgery Society Congress, Montreaux, Switzerland, May 28-June 1, 2017. e-Pub 2017.
Shimizu Y, Gumin J, Hossain A, Gao F, Shpall EJ, Kondo A, Lang FF. Characterization of patient-derived bone marrow mesenchymal stem cells as virus carriers for the treatment of glioblastoma. The Society for Neuro-Oncology Annual Scientific Meeting, San Francisco, CA, November 16-19, 2017. e-Pub 2017.
Colen R, Zandi F, Kotrotsou A, Hatami M, Singh S, Luedi M, Thomas G, Elakkad A, Sulman E, Lang F, Piwnica Worms D, Zinn P. Preclinical validation of radiogenomics in glioblastoma. 54th Annual Meeting of the American Society of Neuroradiology, Washington, DC, May 21-26. *Won Cornelius G. Dyke Memorial Award, 2016. e-Pub 2016.
Yamashita S, Shahar T, Hossain A, Parker Kerrigan B, Gumin J, Li S, Gao F, Yamasaki K, Shimizu Y, Lang FF. The exosomes derived from BM-hMSCs home to glioma and deliver synthetic microRNA mimics after systemic administration. 107th Annual Meeting of the American Association for Cancer Research, New Orleans, LA, April 16-20, 2016. e-Pub 2016.
Ferson D, Lang F, Calhoun J, Chi L. Super-selective scalp block and opiod sparing as an integral part of enhanced recovery after neurosurgery clinical pathway. 16th World Congress of Anaesthesiologists Meeting, Hong Kong, China, August 28-September 2, 2016. e-Pub 2016.
Lang FF, Conrad C, Gomez-Manzano C, Tufaro F, Sawaya R, Weinberg J, Prabhu S, Fuller G, Aldape K, Fueyo J. Phase I clinical trial of oncolytic virus Delta-24-RGD (DNX-2401) with biological endpoints: implications for viro-immunotherapy. 83rd American Association of Neurological Surgeons Annual Scientific Meeting, Washington, DC, May 2-6. *Won Journal of Neuro-Oncology Award, 2015. e-Pub 2015.
Medeiros RR, Tummala S, Levine N, Rao G, Lang FF, Weinberg J, Sawaya R, Suki D, Prabhu S, Grosso M. Feasibility of lower extremity mapping generated with nTMS and correlation with direct intraoperative electrical stimulation. 83rd American Association of Neurological Surgeons Annual Scientific Meeting, Washington, DC, May 2-6, 2015, 2015. e-Pub 2015.
Rotta R, Tummala S, Guillory S, Prabhu S, Rao G, Levine N, Suki D, Lang FF, Weinberg J, Sawaya R. Speech maps generated by nTMS and correlation with direct intraoperative electrical stimulation. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Jiang H, Lang FF, Fan X, Gumin J, Bover L, Clise-Dwyer K, Toniatti C, Ruisaard K, Conrad C, Vence L, Gomez-Manzano C, Fueyo J. Delta-24-RGDOX: targeting co-stimulatory immune checkpoint proteins with oncolytic adenoviruses. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Nilsson CL, Wildburger NC, Gumin J, Kroes RA, Moskal JR, Mechref Y, Lang FF. Improvement of human mesenchymal stem cell homing in delivery of therapeutic agents to glioma stem cell xenografts. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Singh S, Burrell K, Alamsahebpour A, Koch E, Agnihotri S, Gumin J, Sulman E, Lang FF, Wouters B, Aldape K, Zadeh G. Glioma stem cell specific microRNA-mRNA interaction network. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Singh S, Burrell K, Alamsahebpour A, Agnihotri S, Vartanian A, Jalali S, Gumin J, Sulman E, Lang FF, Zadeh G. DICER regulates glioma stem cell state. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Wang Q, Ezhilarasan R, Zheng S, Gumin J, Heffernan T, Draetta G, Lang FF, Verhaak R, Sulman E. Validation of glioma sphere-forming cells as models of glioblastoma and identification of novel drivers of tumorigenesis through comprehensive genomic characterization. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Wang Q, Ezhilarasan R, Zheng S, Gumin J, Heffernan T, Draetta G, Lang F, Verhaak R, Sulman E. Identifying the treatment-resistant mesenchymal signature by comparative analyses between glioma sphere-forming cells and their glioblastomas of origin. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, FL, November 13-16, 2014. e-Pub 2014.
Figueroa JM, Shahar T, Hossain A, Gumin J, Lang FF. Exosomal miRNA from glioma-associated mesenchymal stem cells promote glioma growth and progression. 11th Congress of European Association of Neuro-Oncology Meeting, Turin, Italy, October 9-12, 2014. e-Pub 2014.
Effendi ST, Suki D, Levine NB, Lang FF. Insular glioma resection: The MD Anderson experience. Congress of Neurological Surgery Annual Meeting, Boston, MA, October 18-22. *Won Stryker Neuro-Oncology Award, 2014. e-Pub 2014.
Lang FF, Conrad C, Gomez-Manzano C, Tufaro F, Yung WKA, Sawaya R, Weinberg J, Prabhu S, Fuller G, Aldape K, Fueyo F. First-in-human phase I clinical trial of oncolytic Delta-24-RGD (DNX-2401) with biological endpoints: implications for viro-immunotherapy. 20th International Conference on Brain Tumor Research and Therapy, Lake Tahoe, NV, July 20-23, 2014. e-Pub 2014.
Figueroa J, Shahar T, Hossain A, Gumin J, Lang F. MSC Exosomes Enhance Glioma Stem Cell Viability and Stemness via Delivery of microRNA. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, Scientific Session I, San Francisco, CA, April 5-9. *Won Stryker Neuro-Oncology Award, 2014. e-Pub 2014.
Lichti C, Mostovenko E, Liu H, Shavkunov A, Sulman E, Wang Q, Kroes R, Conrad C, Lang FF, Emmett M, Nilsson C. Label-free quantitative proteomic characterization of glioma stem cell lines defines significantly regulated biological functions and canonical pathways. US HUPO 10th Annual Conference of Frontiers in Proteomics: Advancing Biology through Technology and Computation, Seattle, WA, April 6-9, 2014. e-Pub 2014.
de Groot J, Theeler B, Aldape K, Lang FF, Rao G, Gilbert M, Sulman E, Luthra R, Eterovic K, Chen K, Routbort M, Verhaak R, Mills G, Mendelsohn J, Meric-Bernstam F, Yung A. The PROACTIVE-glioma program at MD Anderson: gateway to personalized medicine trials for glioma. 4th Quadrennial Meeting of the World Federation of Neuro-Oncology (WFNO) in conjunction with 2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO), San Francisco, CA, November 21-24, 2013. e-Pub 2013.
Thomas JG, Hossain A, Shinojima N, Gumin J, Nwajei F, Ezhilarasan R, Love P, Sulman E, Lang FF. Ionizing radiation augments glioma tropism of mesenchymal stem cells. American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, April 27-May 1. *Won Integra Foundation Award, 2013. e-Pub 2013.
Fueyo J, Sawaya R, Lang FF. Significance of cancer autoantibodies in patients with malignant gliomas treated with Delta-24-RGD. American Academy of Neurology 65th Annual Meeting, Platform Presentation, San Diego, CA, March 16-23, 2013. e-Pub 2013.
Effendi ST, Suki D, Levine NB, Lang FF. Insular Glioma Resection: The MD Anderson Experience. Congress of Neurological Surgeons Annual Meeting, San Francisco, CA, October 19-23, 2013. e-Pub 2013.
Jiang H, Klein SR, Piya S, Vence L, Yung WK, Sawaya R, Heimberger A, Conrad C, Lang FF, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus Delta-24-RGD infection activates T-cell immune response against glioma cells. 4th Quadrennial Meeting of the World Federation of Neuro-Oncology (WFNO) held in conjunction with the Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO), San Francisco, CA, November 21-24, 2013. e-Pub 2013.
Figueroa J, Shahar T, Hossain A, Lang FF. The glioma-enhancing role of mesenchymal stem cell exosomes within the tumor microenvironment. European Association of Neurosurgical Societies, AANS/CNS Section on Tumors Annual International Neuro-Oncology Updates Meeting, Tel Aviv, Israel, November 11-14, 2013. e-Pub 2013.
Wang F, Wei J, Xu S, Ling X, Kong LY, Weinberg JS, DeMonte F, Levine NB, Lang FF, Prabhu S, Heimberger A. Glioblastoma exosomes induce immune suppressive M2 macrophages by direct nuclear transfer of STAT3. The American Academy of Neurological Surgery 75th Annual Meeting, Newport Beach, CA, September 25-28, 2013. e-Pub 2013.
Kim B, Jiang W, Beiko J, Prabhu S, DeMonte F, Lang FF, Gilbert M, Aldape K, Sawaya R, Cahill D, McCutcheon I. IDH1 status as a diagnostic and prognostic marker for malignant astrocytomas with limited histological specimen: the role of surgical resection, pathological analysis and molecular testing. 4th Quadrennial Meeting of the World Federation of Neuro-Oncology (WFNO) in conjunction with 2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO), San Francisco, CA, November 21-24, 2013. e-Pub 2013.
Cahill DP, Beiko J, Suki D, Prabhu S, Weinberg J, Lang FF, Sawaya R, Rao G, McCutcheon I, Barker FG, Aldape KD. Multivariate prediction of IDH1 mutation status in malignant astrocytomas. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Wang F, Wei J, Gjyshi O, Kong LY, Xu S, Lang FF, Calin G, Heimberger AB. The microRNA regulatory axis of STAT3: implications for glioma stem cell biology. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Hossain MB, Cortes-Santiago N, Gururaj A, Thomas J, Gabrusiewicz K, Gumin J, Xipell E, Lang FF, Fueyo J, Yung WKA, Gomez-Manzano C. Unexpected nuclear sublocalization of the tyrosine kinase receptor TIE2 induces radioresistance of malignant gliomas. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Singh SK, Vartanian A, Gumin J, Sulman EP, Lang FF, Zadeh G. Role of microRNA mediated mechanisms for maintenance of metabolic status in glioma derived stem cells. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Nilsson CL, Sulman E, Liu H, Wild C, Lichti CF, Emmett MR, Lang FF, Conrad C. Protein expression in glioma-derived stem-like cells correlated to gene expression data and patient outcomes. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Cahill DP, Beiko J, Cheung V, Suki D, Sawaya R, Prabhu S, Lang FF, Aldape K, Rao G, McCutcheon I. IDH1 status determines the survival benefit of surgical resection for malignant astrocytomas. 80th American Association of Neurological Surgeons Annual Scientific Meeting, Miami, Florida, April 14-18. *Won Ronald L. Bittner Award on Brain Tumor Research, 2012. e-Pub 2012.
Lang FF, Wu A, Trinh V, Suki D, Hess K, Weinberg J, McCutcheon I, Prabhu S, Heimberger A, Sawaya R. A prospective randomized trial of seizure prophylaxis in patients undergoing surgery for supratentorial intraparenchymal tumors. 80th American Association of Neurological Surgeons Annual Scientific Meeting, Miami, FL, April 14-18. *Won the National Brain Tumor Society Mahaley Award, 2012. e-Pub 2012.
Wei J, Kong LY, Wang F, Xu S, Doucette TA, Ferguson SD, Yang Y, McEnery K, Jethwa K, Gjyshi O, Qiao W, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. MIR-124 as a novel immunotherapeutic molecule to reverse glioma-mediated immune suppression and enhance anti-tumor clearance. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Fu J, Koul D, Yao J, Wang S, Yuan Y, Sulman EP, Colman H, Lang FF, Yung WKA. A novel HSP90 inhibitor, NVP-HSP990, targets cell cycle regulators to produce an anti-glioma effect in olig2-expressing glioma stem cells. 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology Meeting, Washington, DC, November 15-18, 2012. e-Pub 2012.
Lang FF, Figueroa J, Hossain A. Exosomes from glioma-associated mesenchymal stem cells modulate the proliferation of glioma stem cells. The American Academy of Neurological Surgery 74th Annual Meeting, Chatham, MA, October 17-20, 2012. e-Pub 2012.
Cahill DP, Barker FG, Suki D, Prabhu S, Weinberg J, Lang FF, Rao G, McCutcheon IE, Sawaya R. Prolonged survival in patients undergoing aggressive surgery for IDH1-mutant malignant astrocytoma. The American Academy of Neurological Surgery 74th Annual Meeting, Chatham, MA, October 17-20, 2012. e-Pub 2012.
Wei J, Kong LY, Wang F, Xu S, Doucette T, Lang FF, Rao G, Fuller G, Calin GA, Heimberger AB. MicroRNA as a novel immunotherapeutic strategy to reverse glioma-mediated immune suppression and enhance anti-tumor clearance. The American Academy of Neurological Surgery 74th Annual Meeting, Chatham, MA, October 17-10, 2012. e-Pub 2012.
Zinn PO, Sathyan P, Veo B, Lang FF, Sawaya R, Colen RR, Majumder S. Radiogenomic mapping of MRI-FLAIR-phenotypes identifies a novel gene-microRNA regulatory axis to target glioblastoma invasion. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, October 6-10. *Won the Journal of Neuro-Oncology Award, 2012. e-Pub 2012.
Cahill DP, Beiko J, Suki D, Prabhu SS, Weinberg J, Lang FF, Gilbert MR, Rao G, McCutcheon IE, Aldape KD, Sawaya R. IDH1 status and survival benefit from surgical resection of enhancing and non-enhancing tumor in malignant astrocytomas. American Society of Clinical Oncology Annual Meeting, Chicago, IL, June 1-5, 2012. e-Pub 2012.
Kang SG, Shin HD, Mok HS, Park NR, Sim JK, Shin HJ, Park YK, Jeun SS, Hong YK, Lang FF. Presence of Korean glioma stroma mesenchymal stem cells from glioma specimens. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Zinn PO, Sathyan P, Veo B, Lang FF, Sawaya R, Colen RR, Majumder S. (188) Radiogenomic mapping of MRI-FLAIR-phenotypes identifies a novel gene-microRNA regulatory axis to target glioblastoma invasion. Congress of Neurological Surgeons Annual Meeting, Washington, DC, October 1-6, 2011. e-Pub 2011. PMID: 22811177.
Hossain A, Shinojima N, Gumin J, Gao F, Lang FF. Tumor associated mesenchymal stromal cells increase proliferation and maintain stemness of glioma stem cells through the IL6/STAT3 pathway. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Fu J, Koul D, Wang S, Yao J, Gumin J, Sulman E, Lang FF, Aldape K, Colman H, Yung WKA. Glioblastoma stem cell subtypes display different patterns in neural differentiation, growth, and invasiveness. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Gehring K, Sawyer AM, Etzel CJ, Lang FF, Wefel JS. Prediction of language outcomes after resection of high grade glioma. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Prabhu SS, Abuelem T, Suki D, McCutcheon I, Weinberg J, Lang FF, DeMonte F, Sawaya R. Surgery for gliomas adjacent to motor cortex and factors influencing surgical management in 365 cases. American Association of Neurological Surgeons Annual Meeting, Denver, CO, April 9-13, 2011. e-Pub 2011.
Koul D, Fu J, Yao J, Wang S, Gumin J, Sulman E, Lang FF, Aldape K, Colman H, Yung WKA. TGF-Beta signaling pathway mediates resistance to PI3K inhibition in glioma stem cells. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Gehring K, Sawyer AM, Etzel CJ, Lang FF, Wefel JS. Prediction of memory outcomes after resection of high grade glioma. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Piya S, White E, Klein S, Jiang H, Lang FF, Yung WKA, Gomez-Manzano C, Fueyo J. Delta-24-RGD modulates autophagy in glioma cells by activation of the Beclin1/PI3KC3 complexes. Society for NeuroOncology Scientific Meeting, Orange County, CA, November 17-20, 2011. e-Pub 2011.
Fu J, Shen RJ, Colman H, Lang FF, Yung WKA, Koul D. Molecular and lineage characterization of glioma stem cells. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
Wu ASG, Wei J, L-Y K, Wang Y, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioma cancer stem cells induce immune suppressive macrophages. American Association for Cancer Research 101st Annual Meeting, Washington, DC, April 17-21, 2010. e-Pub 2010.
Goodman LD, Gao F, Gumin J, Villareal D, Ezhilarasan R, Love P, Colman H, Lang FF, Aldape KD, Sulman EP. Refinement of the glioma cancer stem cell marker profile. American Association for Cancer Research 101st Annual Meeting, Washington, DC, April 17-21, 2010. e-Pub 2010.
Puduvalli VK, Liu Y, Colman H, Lang FF, Xu J. Targeting glioma stem cells through death receptor activation by AdsTRAIL. American Association for Cancer Research 101st Annual Meeting, Washington, DC, April 17-21, 2010. e-Pub 2010.
Hatiboglu MA, Suki D, Hassaneen W, McCutcheon IE, Lang FF, Prabhu SS, Weinberg JS, Rhines LD, Rao G, Chang EL, DeMonte F, Sawaya RE. Evolution of Neurosurgical Treatment for Brain Metastases Over the Last 15 Years: Experience at a Large Referral Cancer Center. Congress of Neurological Surgeons Annual Meeting, San Francisco, CA, October 16-21. *Won National Brain Tumor Society Mahaley Clinical Research Award, 2010. e-Pub 2010.
Shinojima N, Hossain A, Gumin J, Gao F, Lang FF. TGF-β Mediates the Tropism of Human Mesenchymal Stem Cells (hMSCs) for Malignant Gliomas. Congress of Neurological Surgeons Annual Meeting, San Francisco, CA, October 16-21, 2010. e-Pub 2010.
Andreeff M, Battula L, Wang RY, Chen Y, Ling X, Kidd S, Dembinski JL, Jacamo R, Spaeth E, Konoplev S, Burks J, Hazen A, Schober W, Lu H, Mak D, McQueen T, Shi YX, Tsao TY, Zhou L, Ruvolo V, Ruvolo P, Benito JM, McQueen T, Borthakur G, Duvvuri S, Klopp A, Mani SA, Lang FF, Zeng Z, Carter B, Konblau S, Champlin R, Marini F, Strunk D, Konopleva M. Multipotent mesenchymal stromal cells (MSC) in the tumor/leukemia microenvironment: biology and targeting. University of Heidelberg International Symposium: Stem Cell Research: Opportunities and Risks, Heidelberg, Germany, November 18-20, 2010. e-Pub 2010.
Bhat K, Salazar K, Balasubramaniyan V, Vaillant B, Hollingsworth F, Gumin J, Diefes K, Patel D, Lang FF, Colman H, Aldape K. A regulatory role for Taz in proneural to mesenchymal differentiation in glioblastoma. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
Fu J, Koul D, Shen RJ, Colman H, Lang FF, Jensen MR, Yung WKA. HSP990: An inhibitor of HSP90 chaperon protein targets OLIG2-expressing glioma stem cells. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
He H, Emmett MR, Marshall AG, Ji Y, Conrad CA, Priebe W, Colman H, Lang FF, Madden TL. Induced phenotypic differentiation of glioblastoma stem cells revisited - detection of glycomic response based on metabolic labeling. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
Goodman L, Gao F, Gumin J, Ezhilarasan R, Love P, George A, Colman H, Lang FF, Aldape K, Sulman EP. Identification of CD58 as a novel marker of glioma stem cells which further refines the stem cell marker signature. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
Vaillant BD, Bhat K, Balasubramaniyam V, Wang S, Gumin J, Sulman E, Lang FF, Aldape K, Colman H. Glioblastoma stem cells demonstrate distinct gene expression and transcription factor profiles that mirror specific GBM tumor subtypes. 15th Annual Meeting of the Society for Neuro-Oncology, Montreal, Quebec, Canada, November 18-21, 2010. e-Pub 2010.
Andreeff M, Battula L, Wang RY, Chen Y, Ling X, Kidd S, Dembinski JL, Jacamo R, Spaeth E, Konoplev S, Burks J, Hazen A, Schober W, Lu H, Mak D, McQueen T, Shi YX, Tsao TY, Zhou L, Ruvolo V, Ruvolo P, Benito JM, Borthakur G, Duvvuri S, Klopp A, Mani SA, Lang FF, Zeng Z, Carter B, Kornblau S, Konopleva M, Marini F. Multipotent mesenchymal stromal cells (MSC) - evolving role in cancer and leukemia therapy. Hematologic Malignancies 2010 Sixth International Conference, October 13-16, Houston, TX, Clin Lymphoma Myeloma Leukemia, 2010. e-Pub 2010.
Andreeff M, Ling X, Y-X S, Spaeth E, Watson K, Battula L, Lang FF, Hortobagyi G, Marini F. Stroma and stroma-tumor interactions as therapeutic targets in breast cancer. 2009 NCI Translational Science Meeting, Vienna, VA, November 5-7, 2009. e-Pub 2009.
Doucette TA, Yang Y, Gumin J, Shinojima N, Kang SG, Zhang W, Rao G, Lang FF. Mesenchymal stem cells display tumor specific tropism in a spontaneous brain tumor model. 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors, New Orleans, LA, October 22-24, 2009. e-Pub 2009.
Wei J, Barr J, Kong LY, Yang DS, Sun W, Sharma A, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Cancer stem-like cells from glioblastoma patients mediate immunosuppression that is reversed with STAT-3 blockade. 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors, New Orleans, LA, October 22-24, 2009. e-Pub 2009.
Balasubramaniyan V, Vaillant B, Wang S, Bhat K, Gumin J, Sai K, Yao J, Lang FF, Aldape KD, Colman H. Tumor initiation is independent of differentiation in glioblastoma stem cells. 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors, New Orleans, LA, October 22-24, 2009. e-Pub 2009.
Puduvalli VK, Liu Y, Lang F, Albarraccin C, Fuller G. Ad-sTRAIL, an adenoviral construct expressing coluble TRAIL, improves survival in a bioluminescence imageable intracranial xenograft model of malignant glioma. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Yong RL, Gumin J, Hata N, Marin FC, Andreeff M, Fueyo J, Lang FF. Human bone marrow-derived mesenchymal stem cells harboring oncolytic adenovirus Delta-24-RGD inhibit glioma growth and improve mouse survival after systemic delivery. *Won 1st Place in the Masters Category. The University of Texas M.D. Anderson Trainee Recognition Day, Houston, TX, March 21, 2008. e-Pub 2008.
Colman H, Sai K, Wang S, Popoff S, Aldape KD, Lang FF, Conrad CA, Madden T, Yung A, Priebe W. Effect of a small molecule inhibitor of the JAK2/STAT3 pathway on self-renewal of glioblastoma stem cells. 44th Annual Meeting of the American Society of Clinical Oncology, Chicago, IL, May 30-June 3, 2008. e-Pub 2008.
Sai K, Shuzhen W, Balasubramaniyan V, Aldape K, Lang FF, Conrad C, Madden T, Yung WKA, Priebe W, Colman H. A Novel small-molecule inhibitor of the JAK2/STAT3 pathway blocks self-renewal and induces apoptosis in brain tumor stem cells. 13th Annual Meeting of the Society for Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Wei J, Abou-Ghazal M, Kong LY, Gumin J, Colman H, Priebe W, Lang FF, Heimberger A. Glioma cancer stem cells contribute to immune suppression. 13th Annual Meeting of the Society for Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Balasubramaniyan V, Bhat K, Wang S, Sai K, Sulman E, Iavarone A, Lang FF, Aldape K, Colman H. A role for BHLHB2 in self-renewal and differentiation of glioblastoma stem cells. 13th Annual Meeting of the Society for Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Yong RL, Gumin J, Hata N, Fueyo J, Marini F, Andreeff M, Lang FF. Human bone-marrow derived mesenchymal stem cells harboring Delta-24-RGD inhibit glioma growth and improve mouse survival after systemic delivery. 13th Annual Meeting of the Society for Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Kang SG, Gumin J, Shinojima N, Yong R, Colman H, Lang FF. Isolation of mesenchymal stem cells from the normal brain: Implications for the glioma microenvironment. 13th Annual Meeting of the Society for Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Puduvalli VK, Lang FF, Liu Y. Inhibition of XIAP facilitates TRAIL-induced apoptosis and improves survival in a bioluminescent glioma xenograft model. 13th Annual Meeting of the Society of Neuro-Oncology, Las Vegas, NV, November 20-23, 2008. e-Pub 2008.
Tatsui CE, Gumin J, Rhines LD, Lang FF. A new orthotopic murine model of spinal metastasis: histological correlates and therapeutic applications. The University of Texas M.D. Anderson Trainee Recognition Day, Houston, TX, March 21, 2008. e-Pub 2008.
Patel AJ, Suki D, Hatiboglu MA, Abouassi H, Lang FF, Sawaya R. Factors influencing the risk of local recurrence following resection of a single brain metastasis. Congress of Neurological Surgeons Annual Meeting, September 20-25, 2008. e-Pub 2008.
Lang FF, Amano T, Hata N, Gumin J, Heimberger A, Andreeff M, Marini F, Aldape K, Colman H. Tumor-derived mesenchymal stem cells in human gliomas: isolation and biological effects. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Conrad CA, Sheng X, Ji Y, Colman H, Emmett M, Lang F, Aldape K, Priebe W, Madden T, Nilsson C. Galectin-1 expression in glioblastoma cell lines is associated with p53 gene expression: implications with cell survival, invasive phenotype, presence in CD133 glioma cancer-stem cells (CSC) and poor patient survival. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Sulman EP, Goodman LD, Le TT, Pelloski CE, Bhat K, Gumin J, Lang FF, Colman H, Aldape KD. A novel marker of glioma stem cells that is prognostic for treatment response and patient outcome. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Bhat KP, Pelloski CE, Colman H, Kim SH, Gumin J, Lang FF, Aldape K. YKL-40 mediates mesenchymal transition in glioblastoma via induction of B-catenin signaling. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Pelloski CE, Bhat KP, Zhang L, Diefes KL, Katchy A, Guman J, Nakada M, Sulman EP, Berens ME, Lang FF, Aldape KD. YKL-40 induces lumican expression and promotes invasion in human glioblastoma. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Jiang H, Xu J, Lang F, Colman H, Gomez-Manzano C, Bogler O, Latha K, Yung WKA, Fueyo J. Delta-24-RGD induces autophagy in brain tumor stem cells and prolongs survival in glioma-bearing mice. American Association for Cancer Research Annual Meeting, San Diego, CA, April 12-16, 2008. e-Pub 2008.
Hatiboglu MA, Lang FF, Aldape K, Sawaya R, Weinberg J, Colman H. Bone marrow-derived mesenchymal stem cells are recruited to and alter the growth of human gliomas. 5th Annual Meeting of the Asian Society for Neuro-Oncology, Istanbul, Turkey, November 2-4, 2007. e-Pub 2007.
Kroes R, Conrad C, Lang FF, Colman H, Priebe W, Emmett M, Nilsson C, Moskal J. Glycogene profiling of glioma stem cells. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Popoff S, Aldape K, Wang S, Conrad C, Lang FF, Sai K, Yung A, Priebe W, Colman H. Regulation of glioblastoma stem cell self-renewal by STAT3. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Witgert M, Lang FF, Suki D, Chang E, Meyers C, Wefel J. Baseline cognitive impairment in patients with single brain metastasis. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Amini E, Masoudi A, Fuller G, Ketonen L, Lang FF, Wolff J. Shrinkage of germinoma by dexamethasone only: case report. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Kunwar S, Westphal M, Medhorn M, Ram Z, Sampson J, Byrne R, Lang FF, Tatter S, Piepmeier J, Barnett G, Guha A, Mooij J, Vogelbaum M, Chang S, Croteau D, Sherman J, Puri R. Results from Precise: a randomized phase III study in patients with first recurrent glioblastoma multiforme (GBM) comparing cintredekin besudotox (CB) administered via convention-enhanced delivery (CED) with Gliadel wafers (GW). 12th Annual Meeting of the Society of Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Alonso M, Gomez-Manzano C, Xu J, Piao Y, Jiang H, Yung WKA, Lang FF, Fueyo J. Oncolytic adenoviruses downmodulate MGMT increasing sensibility of brain tumor stem cells to temozolomide: a mechanistic study. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Jiang H, Gomez-Manzano C, Yokoyama T, Alonso M, Kondo S, Xu J, Bekele BN, Colman H, Lang FF, Fueyo J. Oncolytic adenovirus Delta-24-RGD induces efficacious antiglioma activity in brain tumor stem cell models. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Lang FF, Amano T, Hata N, Gumin J, Aldape K, Colman H. Bone marrow-derived mesenchymal stem cells are recruited to and alter the growth of human gliomas. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Hata N, Yong RL, Gumin J, Marini F, Sawwaya R, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells as delivery vehicles for glioma therapy: in vivo functional analyses using bioluminescence imaging. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Hata N, Yong RL, Gumin J, Marini F, Wang RY, Andreeff M, Lang FF. PDGF-beta mediates the tropism of human bone marrow-derived mesenchymal stem cells for malignant gliomas. 12th Annual Meeting for the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Yong RL, Fueyo J, Marini F, Hata N, Gumin J, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells as delivery vehicles for oncolytic adenovirus Delta-24-RGD in the treatment of malignant glioma. 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX, November 15-17, 2007. e-Pub 2007.
Yong RL, Marini FC, Fueyo J, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells as delivery vehicles for oncolytic adenovirus Delta-24-RGD in the treatment of malignant glioma. * Won 2nd Place in the Clinical/Translational Poster Presentation. University of Texas Health Science Center Research Day, Houston, TX, October 19, 2007. e-Pub 2007.
Lang FF, Aldape K, Sawaya R, Colman H. Bone marrow-derived mesenchymal stem cells are recruited to and alter the growth of human gliomas. American Academy of Neurological Surgery Meeting, Henderson, NV, October 31-November 3, 2007. e-Pub 2007.
Lovo EE, Suki D, Lang FF, McCutcheon IE, Hassenbusch S, Sawaya R, Prabhu SS. Surgical outcomes of multiple brain metastases: analysis of 202 patients. Congress of Neurological Surgeons 207 Annual Meeting, San Diego, CA, September 15-20, 2007. e-Pub 2007.
Hata N, Lang FF. Usefulness of FISH and bioluminescent imaging for evaluation of the fate of human mesenchymal stem cells in gliomas. Congress of Neurological Surgeons 2007 Annual Meeting, San Diego, CA, September 15-20, 2007. e-Pub 2007.
Williams BJ, Fox B, Suki D, Maldaun M, Rao G, Sawaya R, Lang FF. Complications of stereotactic radiosurgery for one or two brain metastases. Congress of Neurological Surgeons 2007 Annual Meeting, San Diego, CA, September 15-20, 2007. e-Pub 2007.
Priebe W, Madden T, Conrad C, Ji Y, Hsu S, Fokt I, Lang FF. 2-Deoxy-D-glucose: old molecule, new brain tumor agent inducing autophagy. American Association for Cancer Research Annual Meeting 2007, Los Angeles, CA, April 14-18, 2007. e-Pub 2007.
Puduvalli VK, Xu J, Sampath D, Prabhu S, Lang FF, Liu Y. p21/Waf1 is upregulated in ex-vivo human glioma slice cultures and delays vorinostat-induced cell cycle arrest and apoptosis in vitro. American Association for Cancer Research Annual Meeting 2007, Los Angeles, CA, April 14-18, 2007. e-Pub 2007.
Yong RL, Marini FC, Andreef M, Fueyo J, Lang FF. Bone marrow-derived human mesenchymal stem cells as delivery vehicles for oncolytic adenovirus Delta-24-RGD in the treatment of malignant glioma. University of Texas M.D. Anderson Cancer Center Trainee Recognition Day, *Awarded the Alumni & Faculty Association Award in Clinical/Translational Research for Best Poster. May 25, 2007. e-Pub 2007.
Andreeff M, Dembinski J, Studeny M, Ling X, McQueen T, Lang FF, Klopp A, Marini FC. Mesenchymal stem cells selectively engraft into tumor stroma and produce potent antitumor proteins in situ. 43rd American Society of Clinical Oncology Annual Meeting, Chicago, IL, June 1-5, 2007. e-Pub 2007.
Kim SS, McCutcheon IE, Sawaya R, Weinberg JS, Lang FF, Heimberger AB, DeMonte F, Hassenbusch SJ, Rhines L, Ferson DZ, Wefel J, Suki D, Prabhu SS. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcome in 300 consecutive patients. 75th Annual Meeting of the American Association of Neurological Surgeons, Washington, DC, April 14-19. *Recipient of the Mahaley Award, 2007. e-Pub 2007.
Feiz-Erfan I, Suki D, Shi W, Heimberger A, DeMonte F, Sawaya R, Lang FF. Extent of resection does increase survival in a select group of patients with newly diagnosed untreated anaplastic astrocytoma (WHO III). 56th Annual Meeting of the Congress of Neurological Surgeons, Chicago, IL, October 7-12, 2006. e-Pub 2006.
Majumder S, Gopalakrishnan V, Su X, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart C. Transcriptional remodeling in neural stem/progenitor cells: roles in neuroregeneration and neural tumors. 7th Annual Congress of the European Association for Neuro-Oncology, Vienna, Austria, September 14-17, 2006. e-Pub 2006.
Conrad CA, Meyer C, Madden T, Priebe W, Lang FF. Survival study of RTA 744 (currently a single agent phase I study) alone and in combination with temozolomide in orthotopic model of glioma. 42nd Annual American Society of Clinical Oncology (ASCO) Meeting, Atlanta, GA, June 2-6, 2006. e-Pub 2006.
Lang FF, Nakamizo A, Amano T, Hata N, Marini F, Andreeff M. Human bone marrow-derived mesenchymal stem cells as delivery vehicles for glioma therapy. 2006 International Brain Tumor Research and Therapy Meeting (Asilomar), Napa Valley, CA, April 26-30, 2006. e-Pub 2006.
Conrad CA, Madden T, Ji Y, Hsu S, Lang FF, Priebe W. Inhibition of glycolysis represents a legitimate target for the therapy of malignant gliomas. 2006 International brain tumor research and therapy meeting (Asilomar), Napa Valley, CA, April 26-30, 2006. e-Pub 2006.
Vogelbaum MA, Sampson JH, Kunwar S, Chang S, Lang FF, Shaffrey ME, Asher AL, Croteau D, Parker K, Lauay C, Sherman JW, Puri RK. Results of a phase I study: convection-enhanced delivery of cintredekin besudotox (IL13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant glioma patients. 2006 American Association of Neurological Surgeons Annual Meeting, San Francisco, CA, April 22-27, 2006. e-Pub 2006.
Alonso M, Alemany R, Gomez-Manzano C, Cascallo M, Lang FF, Xu J, Henry V, Yung WKA, Fueyo J. New alliance against gliomas: treatment with oncolytic adenovirus ICOVIR-5 in combination with TZM or RAD001 significantly improves survival in glioma xenografts. AACR Annual Meeting, Washington, DC, April 2-5, 2006. e-Pub 2006.
Lang FF, Nakamizo A, Marini F, Andreeff M. Human bone marrow-derived mesenchymal stem cells as delivery vehicles for glioma therapy. American Academy of Neurological Surgery Meeting, Greensboro, CA, October 18-21, 2006. e-Pub 2006.
Lee OH, Fueyo J, Xu J, Fuller G, Aldape K, Colman H, Gumin J, Lang FF, Yung WKA, Gomez-Manzano C. Glial Tie2 is co-expressed with stem cell-like markers and mediates adhesion of neoplastic astrocytes to tumoral vascular structures. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Dai B, Kang SH, Lang FF, Pelloski CE, Aldape KD, Sawaya R, Huang S. FoxMIB is overexpressed in human glioblastomas and critically regulates the tumorigenicity and invasion of glioma cells. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Alonso MM, Gomez-Manzano C, Jiang H, Lee OH, Piao Y, Lang FF, Yung WKA, Fueyo J. Combination therapy of D24-RGD with temozolomide and RAD001 with oncolytic adenoviruses induces the regression of glioma xenografts and significantly prolongs survival. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Jiang H, Lee OH, Aoki H, Kondo S, Lang FF, Kondo Y, Yung WKA, Fueyo J. Delta-24-RGD induces autophagy in cancer stem cells. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Vogelbaum MA, Sampson JH, Kunwar S, Chang SM, Lang FF, Shaffrey M, Asher AL, Croteau D, Parker K, Dul JL, Sherman JW, Puri RK. Phase I study final safety results: convection-enhanced delivery of cintredekin besudotox (IL13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant glioma. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Wang S, Popoff S, Roemer M, Gumin J, Jiang H, Lang FF, Fueyo J, Gomez-Manzano C, Aldape K, Newsham I, Gobler O, Colman H. Glioblastoma-derived tumor stem cells maintain stable genetic and epigenetic alterations relative to the parent tumor and demonstrate differential response to temozolomide in vitro. 11th Annual Meeting of the Society for Neuro-Oncology, Orlando, FL, November 16-19, 2006. e-Pub 2006.
Kunwar S, Ram Z, Sampson JH, Prados M, Chang S, Lang FF, Piepmeier JM, Gutin PH, Croteau DJ, Puri RK. Intraparenchymal convection-enhanced delivery (CED) of cintredekin besudotox (CB or IL13-PE38QQR): results of multicenter phase I studies in recurrent malignant glioma (MG). 56th Annual Meeting of the Congress of Neurological Surgeons, Chicago, IL, October 7-12, 2006. e-Pub 2006.
Kunwar S, Prados MD, Chang SM, Lang FF, et al. Convection-enhanced delivery of IL13-PE38QQR: results of a multicenter phase I study in recurrent malignant glioma. The 2005 Annual Meeting of the American Association of Neurological Surgeons, New Orleans, LA, April 18, 2005. e-Pub 2005.
Kunwar S, Ram Z, Sampson JH, Prados M, Chang S, Lang FF, Piepmeier JM, Gutin PH, Croteau D, Puri RK. Peritumoral convection-enhanced delivery (CED) of IL13-PE38QQR (IL13PE): Results of multicenter phase 1 studies in recurrent high grade glioma (HGG). World Federation of Neuro-Oncology Second Quadrennial Meeting and the Sixth Meeting of the European Association for Neuro-Oncology, Edinburgh, United Kingdom, May 5-8, 2005. e-Pub 2005.
Suki D, Lang FF, Maldaun M, Change EL, Sawaya R. Complications of stereotactic radiosurgery in patients with brain metastases: considerations for deep and functional brain tumor locations. World Federation of Neuro-Oncology Second Quadrennial Meeting and the Sixth Meeting of the European Association for Neuro-Oncology, Edinburgh, United Kingdom, May 5-8, 2005. e-Pub 2005.
Dagnew E, Rhines LD, Mendel E, Lang FF, Gokaslan Z, McCutcheon I. Single-stage transpedicular vertebrectomy (TVP) with circumferential decompression and fixation for the management of spinal metastasis: a 10-year experience. 55th Annual Meeting of the Congress of Neurological Surgeons, Boston, MA, October 10, 2005. e-Pub 2005.
McPherson CM, Suki D, Mahajan A, Sawaya R, Lang FF. The role of adjuvant post-operative radiotherapy in the management of single brain metastases: an analysis of 404 patients. 55th Annual Meeting of the Congress of Neurological Surgeons, Boston, MA, October 11, 2005. e-Pub 2005.
Vogelbaum MA, Sampson JH, Kunwar S, Chang SM, Lang FF, et al. Convection-enhanced delivery of cintredekin besudotox (IL13-PE38QQR) followed by radiation therapy without and with temozolomide: a phase I study in newly diagnosed malignant glioma patients. 55th Annual Meeting of the Congress of Neurological Surgeons, Boston, MA, October 11, 2005. e-Pub 2005.
Fokt I, Conrad CA, Madden T, Yung WKA, Lang FF, Thapar N, Priebe W. The discovery and development of blood-brain barrier (BBB) penetrating anthracyclines for the treatment of brain tumors. AACR-NCI-EORTC Meeting on Molecular Targets and Cancer Therapeutics, Philadelphia, PA, November 14-18, 2005. e-Pub 2005.
Misha S, Amano T, Lang FF. Dynamic regulation of noxa promoter by phosphorylation of Thr18 and Ser20 of p53. 96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, April 19, 2005. e-Pub 2005.
Vecil GG, Fueyo J, Marini FC, Andreeff M, Lang FF. Human bone marrow-derived stem cells engineered to carry an oncolytic adenovirus (Delta-24) in the treatment of gliomas. AANS/CNS Section on Tumors Sixth Biennial Satellite Symposium, San Francisco, CA, October 21-22, 2004. e-Pub 2004.
Hanbali F, Suki D, Rhines LD, Lang FF, Gokaslan ZL. Free-hand thoracic pedicle screw instrumentation in patients with spine tumors without intraoperative guidance. American Association of Neurological Surgeons 72nd Annual Meeting, Orlando, FL, May 1-6, 2004. e-Pub 2004.
Vecil GG, Maldaun M, Suki D, Lang FF, Sawaya R. Surgical resection of brain metastases following failed stereotactic radiosurgery. American Association of Neurological Surgeons 72nd Annual Meeting, Orlando, FL, May 1-6, 2004. e-Pub 2004.
Hanbali F, Suki D, Nader R, Guinto FC, Rhines LD, Lang FF, Gokaslan ZL. Free-hand thoracic pedicle screw instrumentation without intraoperative imaging guidance. Congress of Neurological Surgeons 54th Annual Meeting, San Francisco, CA, October 16-21, 2004. e-Pub 2004.
Wang E, McGary EC, Hess K, Sawaya R, Conrad CA, Lang FF, Heimberger AB. Rapamycin is efficacious against gliomas and acts as an anti-VEGF and anti-invasion agent. American Association for Cancer Research 95th Annual Meeting, Orlando, FL, March 27-31, 2004. e-Pub 2004.
Jiang H, Alemany R, Gomez-Manzano C, Yung WK, Sawaya R, Lang FF, Fueyo J. Comparison of the antiglioma effect of EIA and EIB055kD-mutant oncolytic adenovirus. AANS/CNS Section on Tumors Sixth Biennial Satellite Symposium, San Francisco, CA, October 21-22, 2004. e-Pub 2004.
Hentschel SJ, Vecil GG, Lang FF. Comparison of the migration capabilities of mesenchymal and bone marrow-derived neural stem cells and 17.2 neural stem cells in brain tissue. AANS/CNS Section on Tumors Sixth Biennial Satellite Symposium, San Francisco, CA, October 21-22, 2004. e-Pub 2004.
Dagnew E, Chernov MF, Lang FF, Langford LA, Sawaya R, DeMonte F. Papillary, keratin-positive pineal region neoplasms: report of 3 cases. AANS/CNS Section on Tumors Sixth Biennial Satellite Symposium, San Francisco, CA, October 21-22, 2004. e-Pub 2004.
Andreeff M, Studeny M, Dembinski J, Konopleva M, Wang RY, Yang HY, Fueyo J, Champlin RE, Lang FF, Marini FC. Mesenchymal stem cells as delivery systems for cancer and leukemia gene therapy. American Society of Clinical Oncology 40th Annual Meeting, New Orleans, LA, June 5-8, 2004. e-Pub 2004.
Lang FF, Nakamizo A, Andreef M, Marini FC. Bone marrow-derived stem cells in the treatment of human gliomas. American Association for Cancer Research 95th Annual Meeting, Orlando, FL, March 27-31, 2004. e-Pub 2004.
Lang FF. Bone marrow-derived stem cells in the treatment of human gliomas. American Association of Neurological Surgeons 72nd Annual Meeting, Orlando, FL, May 1-6, 2004. e-Pub 2004.
Lang FF, Nakamizo A, Marini FC, Andreef M. Mesenchymal stem cells in the treatment of human gliomas. 3rd Annual Conference on Mesenchymal and Nonhematopoietic Stem Cells: Focus on Adult Stem Cells, New Orleans, LA, October 9-11 (*Won Best Abstract Award), 2003. e-Pub 2003.
Nakamizo A, Lang FF, Zhang XQ, Benedict WF, Zhang W. Adenovirus-mediated transfer of a constitutively phosphorylated p53 (Ad-p53-P) overcomes the resistance of wild-type p53 gliomas to Ad-p53-induced apoptosis. American Association for Cancer Research Annual Meeting, Toronto, Ontario, Canada, April 5-9 [Meeting was cancelled, will be rescheduled due to SARS outbreak], 2003. e-Pub 2003.
Zhou YH, Tan F, Shi YX, Glas T, Wathen K, Hess KR, Gumin J, Lang FF, Yung WKA. The role of PAX6 in glioblastoma formation: a putative novel suppression pathway. American Association for Cancer Research Annual Meeting, Toronto, Ontario, Canada, April 5-9 [Meeting was cancelled, will be rescheduled due to SARS outbreak], 2003. e-Pub 2003.
Wefel JS, Lang FF, Nader R, Meyers CA. Neurocognitive sequelae of insular region tumors. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Vecil GG, Suki D, McCutcheon IE, Sawaya R, Lang FF. Intraventricular brain metastases. Annual Meeting of the Congress of Neurological Surgeons, Denver, CO, October 18-23, 2003. e-Pub 2003.
Nakamizo A, Zhang XQ, Benedict WF, Zhang W, Lang FF. Adenovirus-mediated transfer of a constitutively phosphorylated p53 (Ad-p53-P) overcomes the resistance of wild-type p53 gliomas to Ad-p53-mediated apoptosis. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Mahankali S, Kumar AJ, Leeds NE, Zhou XJ, Jackson EF, Lang FF, Sawaya RE, Chang EL, Fuller GN. MR evaluation of post-stereotactic radiosurgery imaging patterns in metastatic brain tumors requiring resection. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Lang FF, Nakamizo A, Andreef M, Marini FC. Bone marrow-derived stem cells in the treatment of human gliomas. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Kunwar S, Prados M, Chang S, Lang FF, Aldape K, Yung A, Gutin P, Raizer J, Piepmeier J, Baehring J, Berger M, McDermott M, Sherman J, Grahn A, Croteau D, Puri R. Peritumoral convection-enhanced delivery of IL13-PE38QQR in patients with recurrent malignant glioma - phase I interim results. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Kunwar S, Prados MD, Lang FF, Fleming CK, Aldape K, Gutin PH, Piepmeier JM, Berger M, McDermott M, Puri RK. Intratumoral and peritumoral convection-enhanced delivery (CED) of IL13-PE38QQR, a recombinant tumor-targeted cytotoxin, in recurrent malignant glioma-phase I trial. American Association of Neurological Surgeons 71st Annual Meeting, San Diego, CA, April 29, 2003. e-Pub 2003.
Hanbali F, Maiorello TV, Suki D, Liu JM, Nauta HJ, Lang FF. Pilocytic astrocytoma of the brainstem in children. Annual Meeting of the Congress of Neurological Surgeons, Denver, CO, October 18-23, 2003. e-Pub 2003.
Gomez-Manzano C, Aldape KD, Fueyo J, Xu J, Stolarek R, Hu CH, Lang FF, Yung WKA. The blood vessel-destabilizer tool: angiopoietin-2 as anti-glioma treatment. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Fueyo J, Gomez-Manzano C, Yung WKA, Sawaya R, Lang FF. Dose-dependence antiglioma effect of Delta-24-RGD in the intracranial U-87 MG animal model. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Conrad CA, Ji Y, Gumin J, Lang FF, Sawaya R, Yung WKA, Gomez-Manzano C, Fueyo J. Direct comparison of the antiglioma effects Delta-24-hyCD and Ad-hyCD. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Cohen ZR, Abi-Said D, Shi W, DeMonte F, McCutcheon IE, Hassenbusch SJ, Gokaslan ZL, Sawaya R, Lang FF. Surgical resection of anaplastic astrocytoma: prognostic factors and outcome. American Association of Neurological Surgeons 71st Annual Meeting, San Diego, CA, April 30, 2003. e-Pub 2003.
Chao H, Lang FF, Yung WKA, Liu TJ. Protective role of protein phosphatase 1 in p53-mediated apoptosis. Society for Neuro-Oncology Eighth Annual Meeting, Keystone, CO, November 13-16, 2003. e-Pub 2003.
Chao HX, Lang FF, Shono T, Yung WKA, Liu TJ. Involvement of protein phosphatase 1 in p53-mediated apoptosis. American Association for Cancer Research Annual Meeting, Toronto, Ontario, Canada, April 5-9 [Meeting was cancelled, will be rescheduled due to SARS outbreak], 2003. e-Pub 2003.
Andreeff M, Studeny M, Dembinski J, Cabreira-Hansen M, Zompetta C, Champlin RE, Chada S, Lang FF, Marini FC. Gene-modified non-hematopoietic bone marrow stem cells as delivery systems of therapeutic genes in cancer and leukemia. American Society of Gene Therapy 6th Annual Meeting, Washington, DC, June 6, 2003. e-Pub 2003.
Andreeff M, Studeny M, Dembinski J, Cabriera-Hansen M, Zompetta C, Champlin R, Marini F, Lang FF. Gene-modified MSC integrate in tumor stroma after systemic injection and inhibit tumor growth by paracrine effects of IFNb. Cold Springs Harbor Special Symposium, Cold Springs Harbor, NY, March 20-23, 2003. e-Pub 2003.
Chao H, Lang FF, Yung WA, Liu TJ. Involvement of DNA-PKcs in Ad-p53 induced apoptosis in human glioma cell lines. American Association for Cancer Research 2002 Annual Meeting, Chicago, IL, April 6-11, 2002. e-Pub 2002.
Balasingam V, Weinberg JS, Suki D, Lang FF, Chang E, Hassenbusch S. Radiosurgery for brainstem metastasis: experience at MD Anderson Cancer Center with 27 patients. Congress of Neurological Surgeons 52nd Annual Meeting, Schaumburg, IL, September 21-26, 2002. e-Pub 2002.
Lang FF, Kunwar S, Strauss L, Gutin P, Piepmeier J, McDermott M, Fleming C, Sherman J, Raizer J, Aldape K, Yung WKA, Husain SR, Chang SM, Berger M, Prados M, Puri RK. A clinical study of convection-enhanced delivery of IL13-PE38QQR cytotoxin pre- and post-resection of recurrent GBM. Biennial Satellite Symposium, Chicago, IL, April 12, 2002. e-Pub 2002.
Lang FF, Shono T, Gilbert MR. Ad-p53 sensitizes wild-type p53 gliomas to the topoisomerase I inhibitor SN-38. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Cohen ZR, Abi-Said D, Shi W, DeMonte F, McCutcheon IE, Hassenbusch SJ, Gokaslan ZL, Sawaya R, Lang FF. Surgical resection of anaplastic astrocytoma: prognostic factors and outcome. American Association of Neurological Surgeons 2002 Annual Meeting, Chicago, IL, April 6-11, 2002. e-Pub 2002.
Prabhu SS, Weinberg J, Ferson D, Lang FF, McCutcheon IE, Rhines L, Hassenbusch SJ, Gokaslan ZL, DeMonte F, Sawaya R. Awake craniotomy for parenchymal brain tumors, patient selection, technique and outcome. Biennial Satellite Symposium, Chicago, IL, April 12, 2002. e-Pub 2002.
Conrad CA, Yang M, Hoffman RM, Lang FF, Levin VA. Whole-body fluorescence imaging of intracranial glioblastoma multiforme in mice. American Association for Cancer Research 93rd Annual Meeting, San Francisco, CA, April 6-10, 2002. e-Pub 2002.
Conrad CA, Nakamizo A, Gumi J, Ji Y, Gilbert MR, Yung WKA, Lang FF. Using glioma xenograft models for the evaluation on signal transduction inhibitors in combination with cytotoxic chemotherapy: survival, pathologic and molecular correlates. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Prados MD, Lang FF, Strauss LC, Fleming CK, Aldape K, Kunwar S, Yung WKA, Chang SM, Husain SR, Gutin PH, Raizer JJ, Piepmeier JM, Berger M, MCDermott M, Puri RK. Intratumoral and intracerebral microinfusion of IL13-PE38QQR cytotoxin: phase I/II study of pre-and post-resection infursions in recurrent resectable malignant glioma. American Society of Clinical Oncology 38th Annual Meeting, Orlando, FL, May 18-21, 2002. e-Pub 2002.
Maldaun MVC, Suki D, Shi W, Prabhu S, Lang FF, Sawaya R. Cystic GBM: survival analysis of 19 cases. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Cohen ZR, Suki D, Shi W, Weinberg JS, DeMonte F, McCutcheon IE, Hassenbusch SJ, Gokaslan ZL, Rhines LD, Sawaya R, Lang FF. Surgical resection of anaplastic astrocytoma: prognostic factors and outcome. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
DeMonte F, Lang FF. Tumors of the skullbase in children and adolescents. American Association of Neurological Surgeons 2002 Annual Meeting, Chicago, IL, April 6-11, 2002. e-Pub 2002.
Gilbert MR, Shono T, Lang FF. Role of p53 in the resistance of gliomas to topoisomerase I inhibition. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Prados MD, Lang FF, Herman JW, Strauss LC, Fleming CK, Aldape K, Kunwar S, Yung WKA, Chang SM, Husain SR, Gutin PH, Raizer J, Piepmeier JM, Berger M, McDermott M, Puri RK. Convection-enhanced delivery (CED) by positive pressure infusion for intra-tumoral and peri-tumoral administration of IL13-PE38QQR a recombinant tumor-targeted cytotoxin in recurrent malignant glioma. Fifth Congress of the European Association for Neuro-Oncology, Florence, Italy, September 7-10, 2002. e-Pub 2002.
Chang EL, Hassenbusch SJ, Lang FF, Shiu AS, Allen PK, Sawaya R, Maor MH. What is the optimum timing of radiosurgery for sub-centimeter brain metastases. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Cohen ZR, Suki D, Weinberg JS, Marmor E, Lang FF, Sawaya R. Brain metastases in patients with ovarian carcinoma. Prognostic factors and outcome. Society for Neuro-Oncology Seventh Annual Meeting, San Diego, CA, November 21-24, 2002. e-Pub 2002.
Shono T, Parikh D, Khan A, Khan T, Sawaya R, Schaefer TS, Lang FF. Phosphorylation of serines 15 and 20 is required for apoptotic activity of adenovirus-mediated p53 gene therapy in human gliomas. American Association of Neurological Surgeons 70th Annual Meeting, Toronto, Ontario, Canada, April 21-26, 2001. e-Pub 2001.
Abi-Said D, Gokaslan Z, Lang FF, Owolabi B, Meyers C, Sawaya R. Expectations from and satisfaction with care in patients with newly diagnosed metastatic brain tumors. First Quadrennial Meeting of the World Federation of Neuro-Oncology / Society for Neuro-Oncology Sixth Annual Meeting, Washington, DC, November 15-18, 2001. e-Pub 2001.
Weinberg JS, Milas ZL, Sawaya R, Lang FF, Owolabi B, Abi-Said D. Resection of non-cerebellar juvenile pilocytic astrocytomas. American Association of Neurological Surgeons 70th Annual Meeting, Toronto, Ontario, Canada, April 21-26, 2001. e-Pub 2001.
Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Michael C, Miller D, Sawaya R. A multivariate analysis of 416 patients with glioblastoma multiforme: extent of resection and survival. 12th World Congress of Neurosurgery, Sydney, Australia, September 16-20, 2001. e-Pub 2001.
Lang FF, Fuller GN, Prados M, Sawaya R, Yung WKA. Phase I clinical trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. American Association of Neurological Surgeons 70th Annual Meeting, Toronto, Ontario, Canada, April 21-26, 2001. e-Pub 2001.
Khan T, Shono T, Cerrato JA, Khan A, Tofilon PJ, Sawaya R, Spencer DM, Liu TJ, Lang FF. Mechanisms of adenovirus-p53 mediated radiosensitization of human glioma. American Association for Cancer Research 92nd Annual Meeting, New Orleans, LA, March 24-28, 2001. e-Pub 2001.
Khan A, Gomez-Manzano C, Alemany R, Lemoine M, Shono T, He J, Fueyo J, Fuller GN, Sawaya R, Lang FF. Anti-glioma effect of D24-RGD, a Rb-mutation dependent replicative adenovirus with increased infectivity. American Association of Neurological Surgeons 70th Annual Meeting, Toronto, Ontario, Canada, April 21-26, 2001. e-Pub 2001.
Khan A, Fueyo J, Gomez-Mazano C, Shono T, He J, Lemoine M, Fuller G, Sawaya R, Lang FF. In vivo efficacy of RGD-Delta24, a Rb-inactivation-dependent replicative adenovirus with increased infectivity against human glioma. American Association for Cancer Research 92nd Annual Meeting, New Orleans, LA, March 24-28, 2001. e-Pub 2001.
Fueyo J, Gomez-Manzano C, Lemoine MG, He J, Khan A, Conrad C, Yung WKA, Lang FF. Characterization of the anti-glioma effect of a second-generation conditionally replicating adenovirus unable to bind RB and p53. First Quadrennial Meeting of the World Federation of Neuro-Oncology / Society for Neuro-Oncology Sixth Annual Meeting, Washington, DC, November 15-18, 2001. e-Pub 2001.
Fueyo J, Lemoine MG, Gomez-Manzano C, Rao S, Lang FF, Conrad C, Groves M, Yung WKA. Chemotherapy enhancement of the antiglioma effect of the Delta-24 adenovirus. First Quadrennial Meeting of the World Federation of Neuro-Oncology / Society for Neuro-Oncology Sixth Annual Meeting, Washington, DC, November 15-18, 2001. e-Pub 2001.
Cerrato JA, Lang FF, Yung WKA, T-J L. Attenuating Ad-p53 induced apoptosis by BCL-2 in human glioma cell lines. First Quadrennial Meeting of the World Federation of Neuro-Oncology / Society for Neuro-Oncology Sixth Annual Meeting, Washington, DC, November 15-18, 2001. e-Pub 2001.
Shono T, Khan T, Khan A, Sawaya R, Schaefer TS, Lang FF. Apoptotic activity induced by adenovirus-mediated p53 gene transfer in human gliomas requires phosphorylation of serines 15 and 20. American Association for Cancer Research 92nd Annual Meeting, New Orleans, LA, March 24-28, 2001. e-Pub 2001.
Prados M, Lang FF, Strauss L, Aldape K, Kunwar S, Yung WKA, Husain SR, Chang SM, Gutin P, Raizer J, Piepmeier J, Berger M, Puri RK. Pre- and post-resection interstitial infusions of IL13-PE38QQR cytotoxin: phase I study in recurrent resectable malignant glioma. First Quadrennial Meeting of the World Federation of Neuro-Oncology / Society for Neuro-Oncology Sixth Annual Meeting, Washington, DC, November 15-18, 2001. e-Pub 2001.
Lang FF, Fuller G, Prados M, Yung WKA. Preliminary results of a phase I clinical trial of adenovirus-mediated p53 gene therapy for recurrent gliomas: biological studies. American Society of Clinical Oncology 36th Annual Meeting, New Orleans, LA, May 20-23, 2000. e-Pub 2000.
Milas ZL, Ater JL, Abi-Said D, Moser RP, Sawaya R, Lang FF. Suprasellar pilocytic astrocytomas: a retrospective analysis of 23 patients. 9th International Symposium on Pediatric Neuro-Oncology, San Francisco, CA, June 11-14, 2000. e-Pub 2000.
Khan T, Khan A, Spencer DM, Lang FF. Fas-mediated cell death in human glioma may be blocked by a labile inhibitor that is upstream of the effector caspases. The American Association of Neurological Surgeons Annual Meeting, San Francisco, CA, April 8-13, 2000. e-Pub 2000.
Khan T, Khan A, Spencer DM, Lang FF. Resistance to fas-mediated apoptosis in human gliomas. American Association for Cancer Research Special Conference in Cancer Research, Programmed Cell Death Regulation: Basic Mechanisms and Therapeutic Opportunities, Lake Tahoe, NV, February 27-March 2, 2000. e-Pub 2000.
Shono T, Ikezaki K, Fukui M, Sawaya R, Lang FF. Radiosensitization of glioma cells induced by adenovirus-mediated transfer of p53 gene. Japan Neurosurgical Society 59th Annual Meeting, Fukuoka, Japan, October 26, 2000. e-Pub 2000.
Lang FF, Fuller G, Prados M, Sawaya R, Yung WKA. Phase I clinical trial of adenovirus-mediated p53 gene therapy: preliminary results of biological studies. American Association of Neurological Surgeons and Congress of Neurological Surgeons Section on Tumors 4th Biennial Satellite Symposium, San Francisco, CA, April 13-14, 2000. e-Pub 2000.
Olansen N, DeMonte F, Sawaya R, McCutcheon I, Gokaslan Z, Holland E, Abi-Said D, Shi WM, Lang FF. Surgical resection of intrinsic insular tumors: complication avoidance. Congress of Neurological Surgeons 50th Annual Meeting, San Antonio, TX, September 23-29, 2000. e-Pub 2000.
Eisenstat DD, Kuttesch JF, Leeds N, Fuller G, Levin VA, Lang FF, Baumgartner J, Ater JL. Adjuvant 6-thioguanine, procarbazine, lomustine, and hydroxyurea (TPCH) chemotherapy for childhood high-grade gliomas. 9th International Symposium on Pediatric Neuro-Oncology, San Francisco, CA, June 11-14, 2000. e-Pub 2000.
Russell JS, Lang FF, Huet T, Wilson DR, Tofilon PJ. Radiosensitization by adenovirus-mediated expression of an anti-ras single-chain antibody fragment is accompanied by the inhibition of radiation-induced NF-KB activation. American Association for Cancer Research 91st Annual Meeting, San Francisco, CA, April 1-5, 2000. e-Pub 2000.
Fueyo J, Khan A, Gomez-Manzano C, Shono T, Lemoine M, Alemany R, Curiel DT, Y-X S, Liu TJ, Levin VA, Yung WKA, Lang FF. Treatment of intracranial gliomas with D24-RGD. Society for Neuro-Oncology Fifth Annual Meeting, Chicago, IL, November 9-12, 2000. e-Pub 2000.
Lang FF, Fuller GN, Prados M, Sawaya R, Yung WKA. Preliminary results of a phase I clinical trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological studies. Society for Neuro-Oncology 5th Annual Meeting, Chicago, IL, November 9-12, 2000. e-Pub 2000.
Lacroix M, Abi-Said D, Shi W, DeMonte F, Gokaslan Z, Lang FF, McCutcheon I, Hassenbusch S, Sawaya R. Extent of tumor resection and survival of patients with glioma. American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, April 24-29, 1999. e-Pub 1999.
Abi-Said D, Lacroix M, Shi W, Gokaslan ZL, Hess K, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Michael C, Miller D, Sawaya R. Imaging-based necrosis and the survival of patients with glioblastoma multiforme. 4th Annual Meeting of the Society for Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. e-Pub 1999.
Tofilon PJ, Russell JS, Ritchie JL, Janicot M, Chada S, Wilson DR, Lang FF. Radiosensitization of human brain tumor cell lines induced by the adenovirus-mediated expression of an anti-ras single chain antibody fragment. 4th Annual Meeting of the Society for Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. e-Pub 1999.
Michael C, McCutcheon I, Gokaslan Z, DeMonte F, Sawaya R, Lang FF. Resection of calvarial metastases overlying dural sinuses. Congress of Neurological Surgeons, Boston, MA, October 30-November 4, 1999. e-Pub 1999.
Tofilon PJ, Ritchie JL, Russell JS, Raju U, Lang FF. Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single chain antibody. American Association for Cancer Research 90th Annual Meeting, Philadelphia, PA, April 10-14, 1999. e-Pub 1999.
Lang FF, Cao X, Yung WKA, Tofilon PJ. The "bystander effect" in adenovirus-mediated p53 gene therapy for human gliomas: in vitro studies. American Association of Neurological Surgeons Annual Meeting, Philadelphia, PA, April 25-30, 1998. e-Pub 1998.
Lang FF, Yung WKA, Tofilon PJ. Adenovirus-mediated p53 gene transfer combined with radiation or chemotherapy against human gliomas. The Section on Tumors of the American Association of Neurological Surgeons and Congress of Neurological Surgeons 3rd Biennial Brain Tumor Satellite Symposium, Philadelphia, PA, April 30-May 1, 1998. e-Pub 1998.
Lang FF, Yung WKA, Tofilon PJ. Adenovirus-mediated delivery of the p53 gene sensitizes human gliomas to 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). Congress of Neurological Surgeons Annual Meeting, New Orleans, LA, September 27-October 2, 1997. e-Pub 1997.
Lang FF, Yung WKA, Tofilon PJ. Adenovirus-mediated delivery of the p53 gene sensitizes human gliomas to 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). 2nd Annual Meeting of the Society for Neuro-Oncology, Charlottesville, VA, October 31-November 2, 1997. e-Pub 1997.
Lang FF, Tofilon PJ, Yung WKA. The effects of combined p53 gene therapy and adjuvant irradiation in the treatment of human gliomas harboring mutant and wild-type p53 gene. American Association of Neurological Surgeons Annual Meeting, Denver, CO, April 12-17, 1997. e-Pub 1997.
Lang FF, Yung WKA, Tofilon PJ. Adenovirus mediated delivery of p53 enhances the radiosensitivity of wild-type p53 glioma cells. 12th International Conference on Brain Tumour Research and Therapy Annual Meeting, Oxford, UK, September 20-23, 1997. e-Pub 1997.
Gokaslan ZL, McCutcheon IE, Lang FF, Sawaya R. Cervical thoracic stabilization and fusion in cancer patients. American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Disorders of the Spine and Peripheral Nerves, Newport Beach, CA, February 19-22, 1997. e-Pub 1997.
Lang FF, DeMonte F. Calvarial and extracalvarial primary meningiomas. Congress of Neurological Surgeon Annual Meeting, Montreal, Quebec, Canada, September 28-October 3, 1996. e-Pub 1996.
Lang FF, DeMonte F. Intracalvarial meningiomas of the head and neck. Second International Skull Base Congress and Seventh Annual Meeting of the North American Skull Base Society, San Diego, CA, June 29-July 4, 1996. e-Pub 1996.
Gokaslan ZL, McCutcheon IE, Lang FF, Sawaya R. Cervical thoracic stabilization and fusion in cancer patients. Congress of Neurological Surgeons Annual Meeting, Montreal, Quebec, Canada, September 28-October 3, 1996. e-Pub 1996.
Simon C, Lang FF, Holzman RS. Successful treatment of acinetobacter calcoaceticus ventriculitis and development of subsequent chemical meningitis following intraventricular polymyxin B. Infectious Disease Society of America Annual Meeting, Orlando, FL, October 7-10, 1994. e-Pub 1994.
Newcomb EW, Lang FF, Miller DC, Frankel RH, Madonia W, Pisharody S, Koslow M. The role of p53 in the molecular biology of brain tumors. p53 in Growth Control and Neoplasia, Zurich, March 24-27. Charles Rudolphe Brupbacker Foundation 1993;39.1-39.3, 1993. e-Pub 1993.
Lang FF, Koslow M, Miller DC, Newcomb EW. Tumor progression in human glioma: a molecular analysis of 78 astrocytomas of different grades. American Association of Neurological Surgeons Annual Meeting, Boston, MA, April 24-29. J Neurosurg 1993;78:371A, 1993. e-Pub 1993.
Lang FF, Deletis V, Velasquez L, Abbott IR. Lesions of the S2 root in posterior rhizotomy for spasticity: an analysis of variations on a surgical method. Third Annual and First International Scientific and Educational Conference of the American Society of Neurophysiological Monitoring, Pittsburgh, PA, May 14-16, 1992. e-Pub 1992.
Lang FF, Morota N, Abbott IR, Deletis V. Intraoperative recording of cord dorsum potentials in children with spasticity from cerebral palsy: preliminary results. Third Annual and First International Scientific and Educational Conference of The American Society of Neurophysiological Monitoring, Pittsburgh, PA, May 14-16, 1992. e-Pub 1992.
Lang FF, Miller DC, Epstein F. Intramedullary spinal cord gangliogliomas: a clinical pathological study of 27 cases after radical surgical excision. American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, April 20-25. J Neurosurg 1991;74:346A, 1991. e-Pub 1991.
Lang FF, DeLanerolle NC. Neural substrate for vocalization as determined by stimulation of PAG call sites with 2DG and HRP methods. Society for Neuroscience Annual Meeting, Toronto, Canada, November 13-18, 1988. e-Pub 1988.
Lang FF, DeLanerolle NC. Neural substrate for vocalization: patterns of metabolic activity in the cat brain with stimulation of 3 call sites. Society for Neuroscience Annual Meeting, Washington, DC, November 9-14, 1986. e-Pub 1986.

Book Chapters

Lang FF, Evans L, Wildrick DM. Surgical Management of Cerebral Metastases. In: Schmidek & Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results, 7th Ed, Vol 1. Saunders Elsevier, 114, 2022.
Lang FF, Liau LM, Price SJ, Wu J. Left insular high-grade glioma. In: Intrinsic and Skull Base Tumors. 1st. Elsevier, 2020.
Zinn P, Evans L, Lang FF. Transsylvian Approach to Intrinsic Brain Tumors: Insular Tumors. In: Comprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors. Elsevier, 357-377, 2019.
Parker Kerrigan BC, Hossain A, Yamashita S, Lang FF. Stem Cell Therapy of Gliomas. In: Intracranial Gliomas: Part III, Innovative Treatment Modalities. Karger, 124-151, 2018.
Parker-Kerrigan B, Shahar T, Yamashita S, Lang FF. The role of mesenchymal stromal cells in human brain tumors. In: The Biology and Therapeutic Application of Mesenchymal Cells. John Wiley and Sons, Inc, Section VII: Mesenchymal Stromal Cells as Delivery Vehicles for , 2017.
Parker-Kerrigan B, Lang FF. Mesenchymal stem cell recruitment by central nervous system tumors. In: Mesenchymal Stem Cells as Stromal Modulators. 1st. Elsevier, 227-251, 2016.
Siu TL, Lang FF. Surgical Management of Cerebral Metastases. In: Quinones-Hinojosa A (ed). In: Schmidek & Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results. 6th Ed, Vol 1. Saunders Elsevier, 178-91, 2012.
Chern JJ, Rao G, Lang FF. Medulloblastoma. In: Winn HR (ed). In: Youmans Neurological Surgery. 6th ed. 6th. Elsevier Saunders, 1373-82, 2011.
Lang FF, Chang EL, Suki D, Wildrick DM, Sawaya R. Metastatic Brain Tumors. In: Winn HR, (ed). In: Youmans Neurological Surgery, 6th Edition. 6th. Elsevier Saunders, 1410-25, 2011.
Sawaya R, Bindal RK, Lang FF, Suki D. Metastatic Brain Tumors. In: Kaye AH, Laws ER, (eds). In: Brain Tumors: An Encyclopedic Approach. 3rd Edition. Elsevier Saunders, 864-92, 2011.
Wu A, Lang FF. Insular Tumors. In: Mehta MP, Chang SM, Guha A, Newton HB, Vogelbaum MA (eds). In: Principles and Practice of Neuro-Oncology: A Multidisciplinary Approach. Demos Medical Publishers, 505-17, 2011.
Lang FF, Sawaya R. Metastatic Brain Tumors. In: Bernstein M, Berger MS, (eds). In: Neuro-Oncology: The Essentials, 2nd Edition. Theime Medical Publishers, 367-378, 2007.
Yao K, Lang FF. Surgical Approaches to Tumors of the Third Ventricle. In: Badie B, (ed). In: Neurosurgical Operative Atlas 2nd Edition - Neuro-Oncology. Thieme, 42-53, 2007.
Lang FF. Low-Grade Gliomas: Evidence-Based Treatment Options. In: DeMonte F, Gilbert MR, Mahajan A, McCutcheon IE, (eds). In: Tumors of the Brain and Spine. In: Buzdar AU, Freedman RS, (eds). Series: M.D. Anderson Cancer Care. Springer, 93-119, 2007.
Vecil GG, Fueyo J, Lang FF. Tumor-Specific Replicating Adenoviruses: Delta-24 for Human Gliomas. In: Hunt KK, Vorburger SA, Swisher SG, (eds). In: Cancer Drug Discovery and Development: Gene Therapy for Cancer. Humana Press, 331-48, 2007.
Jiang H, McCormick F, Gomez-Manzano C, Curiel DT, Lang FF, Yung WKA, Fueyo J. Replicating Viruses for Brain Tumor Treatment. In: Lowenstein PR, Castro MG, (eds). In: Gene Therapy for Neurological Disorders. Taylor and Francis Group, 293-325, 2006.
Hentschel SJ, Lang FF. Surgical Management of Cerebral Metastases. In: Schmidek & Sweet, (eds). In: Operative Neurosurgical Techniques. Elsevier Publishing, 639-51, 2005.
Kunschner L, Lang FF. Medulloblastoma. In: Winn HR, (ed). In: Youmans Neurological Surgery, 5th Edition. W.B. Saunders Company, 1031-42, 2004.
Hentschel S, Lang FF. Current Surgical Management of Glioblastoma. In: Markert J, DeVita VT, Rosenberg SA, Hellman S, (eds). In: Glioblastoma Multiforme. Jones and Bartlett Publishers, 108-30, 2004.
Lang FF. Surgical management and techniques. In: Sawaya R, (ed). In: Intracranial Metastases: Current Management Strategies. Blackwell/Futura, 106-25, 2004.
Lang FF, Abi-Said D, Chang EL, Wildrick DM, Sawaya R. Metastatic brain tumors. In: Winn HR, (ed). In: Youmans Neurological Surgery, 5th Edition. W.B. Saunders Company, 1077-97, 2004.
Choi W, Lang FF, Zhang W. Functional inactivation of p53 in gliomas. In: Zhang W, Fuller GN, (eds). In: Genomic and Molecular Neuro-Oncology. Jones and Bartlett Publishers, 31-46, 2004.
Lang FF. Primary soft tissue sarcomas of the central nervous system. In: Pollock RE, (ed). In: Central Nervous System Sarcomas. B.C. Decker Inc, 189-203, 2002.
Sawaya R, Bindal RK, Lang FF, Abi-Said D. Metastatic brain tumors. In: Kaye AH, Laws ER, (eds). In: Brain Tumors: An Encyclopedic Approach, 2nd Edition. Churchill Livingstone, 999-1026, 2001.
Lang FF, Wildrick DM, Sawaya R. Metastatic brain tumors. In: Bernstein M, Berger MS, (eds). In: Essential Neuro-Oncology. Thieme, 329-37, 1999.
Lang FF, Sawaya R. Craniotomy for single and multiple cerebral metastases. In: Maciunas RJ, (ed). In: Advanced Techniques in Central Nervous System Metastases. American Association of Neurological Surgeons, 35-56, 1998.
Lang FF, Kelly PJ. Computer assisted stereotactic laser resection. In: Berger MS, Wilson CB, (eds). In: The Gliomas. W.B. Saunders Company, 391-407, 1998.
Lang FF, Miller DC. Astroglial variants. In: Black PM, Loeffler JS, (eds). In: Cancer of the Nervous System. Blackwell Scientific, 516-48, 1997.
Newcomb EW, Lang FF, Koslow M. Molecular biology of brain tumors. In: Tindall GT, Cooper PR, Barrow DL, (eds). In: The Practice of Neurosurgery. Williams and Wilkins, 477-93, 1995.

Letters to the Editor

Lang FF, Sawaya R, Suki D, McCutcheon IE, Hess KR. Glioblastoma resection. Concerning Sinai et. al.: Response of the MD Anderson Cancer Center Neurosurgical Group. J Neurosurg 116: 1166-8, 2012.

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CV information above last modified March 26, 2026

Frederick Lang, M.D., is a leader in the field of neurosurgery, with a particular focus on deep seated brain tumors located in eloquent brain regions.

Frederick Lang, M.D., with his 2016 lab team.

The Broach Foundation for Brain Cancer Research has pledged $5 million to Dr. Lang's brain tumor research at MD Anderson.

Frederick F. Lang, M.D., FACS, FAANS, FAAAS

About Dr. Lang

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