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Frederick F. Lang, Jr, MD, FACS, FAANS

Present Title & Affiliation

Primary Appointment

Professor (tenure), Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Clinical Research, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Faculty Member, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, Houston, TX
Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Bio Statement

Frederick Lang, MD, FACS, FAANS is Professor and Director of Clinical Research in the Department of Neurosurgery at MD Anderson. He is also Adjunct Professor of Neurosurgery at Baylor College of Medicine, Houston. Dr. Lang was born in Brooklyn, NY. He received his medical degree from Yale University School of Medicine, New Haven, CT. He completed a residency in neurosurgery at New York University Medical Center, and a fellowship in neurosurgical oncology at MD Anderson. Dr. Lang is the recipient of numerous awards and honors, including America's Top Doctors for Cancer, Guide to America's Top Surgeons, the Preuss Research Award, the Mahaley Award, and the Michael S.Voynick Award in Neuro-Oncology.  He is a NIH-funded translational researcher who has published extensively on gene, viral and cellular therapies for brain tumors and is Principal Investigator on multiple clinical trials that investigate these new approaches.  He is currently the Chair of the AANS/CNS Section on Tumors. He is a member of the Board of Directors of the Society for Neuro-Oncology (SNO), and is a past President of SNO. He is board certified in Neurosurgery and is a Fellow of the American College of Surgeons and theAmerican Association of Neurological Surgeons. Dr. Lang is an Associate Editor of Neurosurgery and on the Editorial Board of Neuro-Oncology and Translational Oncology. He served on the Developmental Therapeutic Study Section within the NIH until his tenure ended in 2011, he has continued as an ad hoc reviewer for NIH. He is frequently requested as a national and international lecturer. He has published more than 150 peer-reviewed articles and book chapters. Dr. Lang isa leader in the field of neurosurgery with particular focus on deep seated brain tumors located in eloquent brain regions.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Department of Neurosurgery
Unit Number: 442
Houston, TX 77030
Room Number: FC7.2000
Phone: (713) 792-2400
Fax: (713) 794-4950

Education & Training

Degree-Granting Education

1988 Yale University School of Medicine, New Haven, CT, MD, Medicine
1984 Yale College, Yale University, New Haven, CT, BS, Biology

Postgraduate Training

8/1995-6/1996 Clinical Fellowship, Neurosurgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/1993-7/1995 Clinical Residency, Chief Resident, Department of Neurosurgery, New York University Medical Center, New York, NY
7/1989-6/1993 Clinical Residency, Department of Neurosurgery, New York University Medical Center, New York, NY
6/1988-6/1989 Clinical Internship, General Surgery, New York University Medical Center, New York, NY

Board Certifications

2010 The American Board of Neurological Surgery

Honors and Awards

2007-present Global Directory of Who's Who
2004-present America's Top Doctors for Cancer
2003-present Best Doctors in America

Professional Memberships

American College of Surgeons
Fellow, 2001-present
Harris County Medical Society
Member, 1997-present
Houston Neurological Society
Member, 1997-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Doucette T, Rao G, Yang Y, Gumin J, Shinojima N, Bekele BN, Qiao W, Zhang W, Lang FF. Mesenchymal stem cells display tumor specific tropism in an RCAS/Ntv-a glioma model. Neoplasia 13(8):716-25, 2011. PMID: 21847363.
2. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther 9(1):67-78, 2010. PMCID: PMC2939737.
3. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Sawaya R, Lang FF, Heimberger AB. Glioma-associated cancer-initiating cells induce immunosuppression. Clin Cancer Res 16(2):461-473, 2010. PMCID: PMC2943842.
4. He H, Nilsson CL, Emmett MR, Marshall AG, Kroes RA, Moskal JR, Ji Y, Colman H, Priebe W, Lang FF, Conrad CA. Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation. J Proteome Res 9(5):2098-108, May 7, 2010. PMID: 20199106.
5. Kang S, Shinojima N, Hossain A, Gumin J, Yong R, Colman H, Marini F, Andreeff M, Lang FF. Isolation and perivascular localization of mesenchymal stem cells from mouse brain. Neurosurgery 67(3):711-20, 2010. PMID: 20651630.
6. Hata N, Shinojima N, Gumin J, Yong R, Marini F, Andreeff M, Lang FF. Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas. Neurosurgery 66(1):144-156; discussion 156-157, Jan, 2010. PMCID: PMC2811094.
7. Tatsui CE, Lang FF, Gumin J, Suki D, Shinojima N, Rhines LD. An orthotopic murine model of human spinal metastasis: histological and functional correlations. J Neurosurg Spine 10(6):501-512, June, 2009. PMID: 19558282.
8. Kim SS, McCutcheon IE, Suki D, Weinberg JS, Sawaya R, Lang FF, Ferson D, Heimberger AB, DeMonte F, Prabhu SS. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery 64(5):836-46, May, 2009. PMID: 19404147.
9. Yong R, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta-24-RGD to human gliomas. Cancer Res 69(23):8932-8940, Dec 1, 2009. PMCID: PMC2789204.
10. Amano T, Nakamizo A, Mishra SK, Gumin J, Shinojima N, Sawaya R, Lang FF. Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes. J Neurooncol 92(3):357-71, May, 2009. PMID: 19357962.
11. Williams BJ, Suki D, Fox BD, Maldaun MVC, Sawaya RE, Lang FF, Rao G. Stereotactic radiosurgery for metastatic brain tumors: a comprehensive review of complications. J Neurosurg 111(3):439-448, Sept, 2009. PMID: 19301968.
12. Toms SA, Weil RJ, Gupta A, Boulis NM, Prayson R, Lang FF. Clinical problem solving: island intruder. Neurosurgery 62(4):920-8; discussion 928-9, 4/2008. PMID: 18496198.
13. Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-93, Mar, 3/2008. PMID: 18253154.
14. Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol 10(3):275-291, Jun, 2008. PMCID: PMC2563050.
15. Gilbert MR, Lang FF. Management of patients with low-grade gliomas. Neurol Clin 25(4):1073-88, Nov, 2007. PMID: 17964026.

Invited Articles

1. Gilbert MR, Lang FF. Should patients with anaplastic oligodendroglial tumors receive adjuvant chemotherapy. Nat Clin Pract Neurol 3(1):14-5, 1/2007. PMID: 17205067.
2. Gilbert MR, Lang FF. Anaplastic oligodendroglial tumors: a tale of two trials. J Clin Oncol 24(18):2689-90, 6/2006.

Book Chapters

1. Lang FF, Sawaya R. Supratentorial cerebral metastases. In: Kaye AH, Black PM, (eds). In: Operative Neurosurgery. Churchill Livingstone: Edinburgh, Scotland. In Press.
2. Wu A, Lang FF. Insular Tumors. In: Mehta MP, Chang SM, Guha A, Newton HB, Vogelbaum MA (eds). In: Principles and Practice of Neuro-Oncology: A Multidisciplinary Approach. Ed(s) Mehta MP, Chang SM, Guha A, Newton HB, Vogelbaum MA (eds). Demos Medical Publishers: New York, NY, 505-17, 2011.
3. Chern JJ, Rao G, Lang FF. Medulloblastoma. In: Winn HR (ed). In: Youmans Neurological Surgery. 6th ed. 2, 6th. Ed(s) Win HR (ed). Elsevier Saunders: Philadelphia, PA, 1373-82, 2011.
4. Sawaya R, Bindal RK, Lang FF, Suki D. Metastatic Brain Tumors. In: Kaye AH, Laws ER, (eds). In: Brain Tumors: An Encyclopedic Approach. 3rd Edition. Elsevier Saunders: Philadelphia, PA, 864-92, 2011.
5. Lang FF, Chang EL, Suki D, Wildrick DM, Sawaya R. Metastatic Brain Tumors. In: Winn HR, (ed). In: Youmans Neurological Surgery, 6th Edition. 2, 6th. Ed(s) Winn HR. Elsevier Saunders: Philadelphia, PA, 1410-25, 2011.

Grant & Contract Support

Title: SPORE in Brain Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2013 - 8/31/2018

Last updated: 8/16/2013