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Gabriel N. Hortobagyi, MD, FACP

Present Title & Affiliation

Primary Appointment

Professor of Medicine, Department of Breast Medical Oncology, Division of Cancer Medicine, UTMDACC, Houston, TX
Nellie B. Connally Chair in Breast Cancer, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Program Director, Department of Breast Medical Oncology, Susan G. Komen Interdisciplinary Breast Fellowship Program, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1970 Universidad Nacional de Colombia, Bogotá, Colombia, MD, Medicine
1963 Colegio Helvetia, Bogotá, Colombia, BS

Postgraduate Training

7/1975-6/1976 Clinical Fellowship, Medical Oncology, UT MD Anderson Hospital & Tumor Institute, Houston, TX
7/1971-6/1974 Clinical Residency, Internal Medicine, St. Luke's Hospital, Case-Western Reserve University, Cleveland, OH

Board Certifications

1/1977 American Board of Internal Medicine, Subspecialty
1/1975 American Board of Internal Medicine


Administrative Appointments/Responsibilities

Member, The University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Tenure Track Faculty Member Search Committee, Houston, TX, 8/2013-8/2015
Member of the Internal Advisory Board, The University of Texas MD Anderson Cancer Center Center for Radiation Oncology Research (CROR), Houston, TX, 5/2013-present
Member of the Internal Advisory Board, The University of Texas MD Anderson Cancer Center Multidisciplinary Research Program, Houston, TX, 1/2013-present
Member Intermal Advisory Board, The University of Texas MD Anderson Cancer Center Cancer Prevention and Research Institute of Texas (CPRIT) Multiple Investigator Grant Application entitled “Novel Posttranslational Modifications and Functions of Kinases in Breast Tumor Progression”, P.I., Houston, TX, 11/2011-present
Member, The University of Texas MD Anderson Cancer Center Standing Committee on Faculty Awards, Houston, TX, 8/2011-present
Member of the Internal Advisory Board, The University of Texas MD Anderson Cancer Center Program Project "Growth Factor Receptor Signaling in Breast Cancer and Metabolic Regulation", P.I.: M-C Hung, Houston, TX, 6/2010-present
Department Chair, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/1992-8/2012
Medical Director, Multidisciplinary Breast Cancer Research Program, UTMDACC, Houston, TX, 9/1991-9/2012

Honors and Awards

2013-2014 Best Doctors In America,
2013 America's Top Doctors, 12th Ed., 2013, Castle Connolly Medical, Ltd., New York, NY
2012 America’s Top Doctors, 11th Ed., 2012, Castle Connolly Medical, Ltd., New York, NY
2012 Breast Journal Club Award for Best Publication in Breast Oncology in 2012, Naples, Italy
2012 Honorary President, Breast-Gynecological Cancer Society
2012 Jill Rose Award, The Breast Cancer Research Foundation, New York, NY
2012 Texas Super Doctors, 2012, Texas Monthly, 40(12)S-24, 2012
2012 Top Doctors: Southeastern Texas, 1st Ed, Caste Connolly Medical, Ltd., New York, NY
2012 Top Medical Oncologists, Top Doctors, US News,
2012 Who is Who Magyarországon, (a member of the Hübners Who is Who), 10th Ed., 2012, Budapest, Hungary
2012 William L. McGuire Award and Memorial Lecture, CTCR-AACR San Antonio Breast Cancer Symposium
2011-present Houston's Top Doctors, H Texas Magazine
2011 Premio Dr. Jenaro Haddock (Dr. Jenaro Haddock Prize and Memorial Lecture), The Asociación de Hematología y Oncología Médica de Puerto Rico, San Juan, PR
2011 2011 Addarii Award and Lecture, (University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy)
2011 2011 Bob Pinedo Cancer Care Prize Award and Keynote Lecture, Society for Translational Oncology, Belfast, Northern Ireland, UK
2011 America’s Top Doctors for Cancer, 7th Ed., Castle Connolly Medical, Ltd., New York, NY
2011 Honorary Member, Tribute Committee of the Silver Rose Gala
2010-2011 Who’s Who in America, Marquis Who’s Who
2009-present John Mendelsohn Lifetime Scientific Achievement Award - Division of CancerMedicine., Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center
2009-present Laurea Honoris Causa (doctor Honoris Causa, Honorary Doctorate in Medicine and Surgery), La Universidad Autonoma de Nuevo Leon, Monterrey Mexico
2009-2012 Charles A. LeMaistre Outstanding Achievement Award in Cancer, The University of Texas M.D. Anderson Cancer Center
2007 Cruz Civica Jorge Bejarano (Bronze Level), Government of Colombia
2003 Glenn Robbins Award, New York Metropolitan Breast Group/New York Cancer Society
2003 Horizon Scientific Achievement Award, Bristol-Myers Squibb and The Susan G. Komen Breast Cancer Foundation, Washington, DC
1999 Vermeille Medal of the City of Paris, (Vermeille), Paris, France
1997 Brinker International Award for Clinical Research, Susan G. Komen Breast Cancer Foundation, San Antonio, TX
1995 Cino del Duca Award, ICACT, Paris France

Professional Memberships

Academia Nacional de Medicina de Buenos Aires, Argentina, Argentina
Corresponding Member, 1993-present
Academia Nacional de Medicina, Mexico, Mexico
Corresponding Member, 1994-present
American Society of Clinical Oncology, Alexandria, VA
President, 5/2006-5/2007
Hungarian Academy of Sciences, Hungary
External Member-Medical Services Section, 2004-present
Southwest Oncology Group
Breast Committee Chair, 2007-present
The American Society of the French Legion of Honor
Member, 2001-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Hertz DL, Barlow WE, Kidwell KM, Albain KS, Vandenberg TA, Dakhil SR, Tirumali NR, Livingston RB, Gralow J, Hayes DF, Hortobagyi GN, Mehta RS, Rae JM. Fulvestrant decreases anastrozole drug concentrations when taken concurrently by patients with metastatic breast cancer treated on SWOG study S0226. Br J Clin Pharmacol 81(6):1134-41, 6/2016. e-Pub 4/8/2016. PMID: 26859101.
2. Rosenstock AS, Lei X, Tripathy D, Hortobagyi GN, Giordano SH, Chavez-MacGregor M. Short-term mortality in older patients treated with adjuvant chemotherapy for early-stage breast cancer. Breast Cancer Res Treat 157(2):339-50, 6/2016. e-Pub 5/2016. PMID: 27146586.
3. Mitri Z, Nanda R, Blackwell K, Costelloe CM, Hood I, Wei C, Brewster AM, Ibrahim NK, Koenig KB, Hortobagyi GN, Van Poznak C, Rimawi MF, Moulder-Thompson S. TBCRC-010: Phase I/II Study of Dasatinib in Combination with Zoledronic Acid for the Treatment of Breast Cancer Bone Metastasis. Clin Cancer Res. e-Pub 5/2016. PMID: 27166393.
4. Mougalian SS, Hernandez M, Lei X, Lynch S, Kuerer HM, Symmans WF, Theriault RL, Fornage BD, Hsu L, Buchholz TA, Sahin AA, Hunt KK, Yang WT, Hortobagyi GN, Valero V. Ten-Year Outcomes of Patients With Breast Cancer With Cytologically Confirmed Axillary Lymph Node Metastases and Pathologic Complete Response After Primary Systemic Chemotherapy. JAMA Oncol 2(4):1-9, 4/1/2016. e-Pub 12/2015. PMCID: PMC4845895.
5. Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, Wang Y, Chou CK, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN, Hung MC. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation. Cancer Res 76(6):1451-62, 3/15/2016. e-Pub 1/12/2016. PMCID: PMC4794388.
6. Lim SO, Li CW, Xia W, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, Wu Y, Sahin A, Hanash SM, Hortobagyi GN, Hung MC. EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape. Cancer Res 76(5):1284-96, 3/1/2016. e-Pub 1/12/2016. PMCID: PMC4775355.
7. Mittendorf EA, Vila J, Tucker SL, Chavez-MacGregor M, Smith BD, Symmans WF, Sahin AA, Hortobagyi GN, Hunt KK. The Neo-Bioscore Update for Staging Breast Cancer Treated With Neoadjuvant Chemotherapy: Incorporation of Prognostic Biologic Factors Into Staging After Treatment. JAMA Oncol. e-Pub 3/17/2016. PMID: 26986538.
8. Rugo HS, Hortobagyi GN, Yao J, Pavel M, Ravaud A, Franz D, Ringeisen F, Gallo J, Rouyrre N, Anak O, Motzer R. Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy. Ann Oncol 27(3):519-25, 3/2016. e-Pub 1/11/2016. PMCID: PMC4769991.
9. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med 22(2):194-201, 2/2016. e-Pub 1/2016. PMCID: PMC4754671.
10. Hortobagyi GN, Chen D, Piccart M, Rugo HS, Burris HA, Pritchard KI, Campone M, Noguchi S, Perez AT, Deleu I, Shtivelband M, Masuda N, Dakhil S, Anderson I, Robinson DM, He W, Garg A, McDonald ER, Bitter H, Huang A, Taran T, Bachelot T, Lebrun F, Lebwohl D, Baselga J. Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2. J Clin Oncol 34(5):419-26, 2/2016. e-Pub 10/2015. PMID: 26503204.
11. Edwards BJ, Sun M, West DP, Guindani M, Lin YH, Lu H, Hu M, Barcenas C, Bird J, Feng C, Saraykar S, Tripathy D, Hortobagyi GN, Gagel R, Murphy WA. Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience. J Bone Miner Res. e-Pub 2/2016. PMID: 26896384.
12. Kogawa T, Fouad TM, Liu DD, Wu J, Shen Y, Masuda H, Fujii T, Chavez-MacGregor M, Alvarez RH, Hortobágyi GN, Valero V, Ueno NT. High HER2/Centromeric Probe for Chromosome 17 Fluorescence In Situ Hybridization Ratio Predicts Pathologic Complete Response and Survival Outcome in Patients Receiving Neoadjuvant Systemic Therapy With Trastuzumab for HER2-Overexpressing Locally Advanced Breast Cancer. Oncologist 21(1):21-7, 1/2016. e-Pub 12/2015. PMCID: PMC4709200.
13. Gagliato DM, Jardim DL, Marchesi MS, Hortobagyi GN. Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2+ breast cancer. Oncotarget. e-Pub 1/2016. PMID: 26824988.
14. Chae YK, Gagliato Dde M, Pai SG, Carneiro B, Mohindra N, Giles FJ, Ramakrishnan-Geethakumari P, Sohn J, Liu S, Chen H, Ueno N, Hortobagyi G, Gonzalez-Angulo AM. The association between EGFR and cMET expression and phosphorylation and its prognostic implication in patients with breast cancer. PLoS One 11(4):e0152585, 2016. e-Pub 4/2016. PMCID: PMC4824503.
15. Kai K, Kondo K, Wang X, Xie X, Pitner MK, Reyes ME, Torres-Adorno AM, Masuda H, Hortobagyi GN, Bartholomeusz C, Saya H, Tripathy D, Sen S, Ueno NT. Antitumor Activity of KW-2450 Against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther 14(12):2687-99, 12/2015. e-Pub 10/2015. PMCID: PMC4674309.
16. Le Du F, Gonzalez-Angulo AM, Park M, Liu DD, Hortobagyi GN, Ueno NT. Effect of 21-Gene RT-PCR Assay on Adjuvant Therapy and Outcomes in Patients With Stage I Breast Cancer. Clin Breast Cancer 15(6):458-66, 12/2015. e-Pub 6/2015. PMCID: PMC4644681.
17. Yamaguchi N, Fujii T, Aoi S, Kozuch PS, Hortobagyi GN, Blum RH. Comparison of cardiac events associated with Liposomal Doxorubicin, Epirubicin, and Doxorubicin in breast cancer; a Bayesian network meta-analysis. Eur J Cancer 51(16):2314-20, 11/2015. e-Pub 9/2015. PMID: 26343314.
18. Hortobagyi GN, El-Saghir NS, Cufer T, Cazap E, de Guzman R, Othieno-Abinya NA, Sanchez JA, Pyle D. The American Society of Clinical Oncology's Efforts to Support Global Cancer Medicine. J Clin Oncol. e-Pub 11/2015. PMID: 26578614.
19. Gonzalez-Angulo AM, Lei X, Alvarez RH, Green MC, Murray JL, Valero V, Koenig KB, Ibrahim NK, Litton JK, Nair L, Krishnamurthy S, Hortobagyi GN, Meric-Bernstam F. Phase II Randomized Study of Ixabepilone Versus Observation in Patients With Significant Residual Disease After Neoadjuvant Systemic Therapy for HER2-Negative Breast Cancer. Clin Breast Cancer 15(5):325-31, 10/2015. e-Pub 3/24/2015. PMCID: PMC4568133.
20. Chaudry M, Lei X, Gonzalez-Angulo AM, Mittendorf EA, Valero V, Tripathy D, Hortobagyi GN, Chavez-MacGregor M. Recurrence and survival among breast cancer patients achieving a pathological complete response to neoadjuvant chemotherapy. Breast Cancer Res Treat 153(2):417-23, 9/2015. e-Pub 8/2015. PMID: 26272743.
21. Shaitelman SF, Schlembach PJ, Arzu I, Ballo M, Bloom ES, Buchholz D, Chronowski GM, Dvorak T, Grade E, Hoffman KE, Kelly P, Ludwig M, Perkins GH, Reed V, Shah S, Stauder MC, Strom EA, Tereffe W, Woodward WA, Ensor J, Baumann D, Thompson AM, Amaya D, Davis T, Guerra W, Hamblin L, Hortobagyi G, Hunt KK, Buchholz TA, Smith BD. Acute and Short-term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation: A Randomized Clinical Trial. JAMA Oncol 1(7). e-Pub 8/2015. PMID: 26247543.
22. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc 90(8):996-1000, 8/2015. e-Pub 7/23/2015. PMID: 26211600.
23. Chavez-MacGregor M, Niu J, Zhang N, Elting LS, Smith BD, Banchs J, Hortobagyi GN, Giordano SH. Cardiac Monitoring During Adjuvant Trastuzumab-Based Chemotherapy Among Older Patients With Breast Cancer. J Clin Oncol 33(19):2176-83, 7/1/2015. e-Pub 5/11/2015. PMID: 25964256.
24. Arun B, Akar U, Gutierrez-Barrera AM, Hortobagyi GN, Ozpolat B. The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells. Int J Oncol 47(1):262-8, 7/2015. e-Pub 5/2015. PMID: 25975349.
25. Mitri ZI, Jackson M, Garby C, Song J, Giordano SH, Hortobágyi GN, Singletary CN, Hashmi SS, Arun BK, Litton JK. BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing. Oncologist 20(6):593-7, 6/2015. e-Pub 5/2015. PMID: 25948675.
26. Sevcikova K, Zhuang Z, Garcia-Manero G, Alvarez RH, Kantarjian HM, Mego M, Albarracin C, Tang G, Strom SS, Medeiros LJ, Hortobagyi GN, Reuben JM, Khoury JD. Comprehensive analysis of factors impacting risks and outcomes of therapy-related myeloid neoplasms following breast cancer treatment. Leukemia. e-Pub 5/2015. PMID: 25975189.
27. Smerage JB, Barlow WE, Hortobagyi GN, Hayes DF. Reply to f.-C. Bidard et Al. J Clin Oncol 33(14):1623, 5/2015. e-Pub 4/2015. PMID: 25870090.
28. Parinyanitikul N, Lei X, Chavez-MacGregor M, Liu S, Mittendorf EA, Litton JK, Woodward W, Zhang AH, Hortobagyi GN, Valero V, Meric-Bernstam F, Gonzalez-Angulo AM. Receptor Status Change From Primary to Residual Breast Cancer After Neoadjuvant Chemotherapy and Analysis of Survival Outcomes. Clin Breast Cancer 15(2):153-60, 4/2015. e-Pub 10/2/2014. PMID: 25454687.
29. Mego M, Zuo Z, Gao H, Cohen EN, Giordano A, Tin S, Anfossi S, Jackson S, Woodward W, Ueno NT, Valero V, Alvarez RH, Hortobagyi GN, Khoury JD, Cristofanilli M, Reuben JM. Circulating tumour cells are linked to plasma D-dimer levels in patients with metastatic breast cancer. Thromb Haemost 113(2):593-8, 3/3/2015. e-Pub 11/6/2014. PMID: 25373787.
30. Hortobagyi GN. Everolimus Plus Exemestane for the Treatment of Advanced Breast Cancer: A Review of Subanalyses from BOLERO-2. Neoplasia 17(3):279-288, 3/2015. PMCID: PMC4372651.
31. Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL, Gelber RD, Hortobagyi GN, Albain KS, POEMS/S0230 Investigators. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med 372(10):923-32, 3/2015. PMID: 25738668.
32. Gonzalez-Angulo AM, Parinyanitikul N, Lei X, Mittendorf EA, Zhang H, Valero V, Hunt KK, Hortobagyi GN, Chavez-MacGregor M. Effect of adjuvant trastuzumab among patients treated with anti-HER2-based neoadjuvant therapy. Br J Cancer 112(4):630-5, 2/17/2015. e-Pub 1/13/2015. PMCID: PMC4333494.
33. Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X, Gagea M, Chavez-MacGregor M, Ueno NT, Lei X, Zhou W, Nair L, Tripathy D, Brown PH, Hortobagyi GN, Chen K, Mendelsohn J, Mills GB, Gonzalez-Angulo AM. Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget 6(5):2604-14, 2/20/2015. e-Pub 12/2014. PMID: 25605252.
34. Mego M, Giordano A, De Giorgi U, Masuda H, Hsu L, Giuliano M, Fouad TM, Dawood S, Ueno NT, Valero V, Andreopoulou E, Alvarez RH, Woodward WA, Hortobagyi GN, Cristofanilli M, Reuben JM. Circulating tumor cells in newly diagnosed inflammatory breast cancer. Breast Cancer Res 17(1). e-Pub 1/9/2015. PMCID: PMC4318180.
35. Budd GT, Barlow WE, Moore HC, Hobday TJ, Stewart JA, Isaacs C, Salim M, Cho JK, Rinn KJ, Albain KS, Chew HK, Burton GV, Moore TD, Srkalovic G, McGregor BA, Flaherty LE, Livingston RB, Lew DL, Gralow JR, Hortobagyi GN. SWOG S0221: A Phase III Trial Comparing Chemotherapy Schedules in High-Risk Early-Stage Breast Cancer. J Clin Oncol 33(1):58-64, 1/1/2015. e-Pub 11/24/2014. PMCID: PMC4268253.
36. Kogawa T, Fouad TM, Wei C, Masuda H, Kai K, Fujii T, El-Zein R, Chavez-MacGregor M, Litton JK, Brewster A, Alvarez RH, Hortobagyi GN, Valero V, Theriault R, Ueno NT. Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer. J Cancer 6(4):310-8, 2015. e-Pub 1/2015. PMCID: PMC4349870.
37. Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC, Yao J, Kleer CG, Hortobagyi GN, Hung MC. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res 7(6):1009-20, 2015. e-Pub 6/2015. PMCID: PMC4532735.
38. Piccart M, Hortobagyi GN, Campone M, Pritchard KI, Lebrun F, Ito Y, Noguchi S, Perez A, Rugo HS, Deleu I, Burris HA, Provencher L, Neven P, Gnant M, Shtivelband M, Wu C, Fan J, Feng W, Taran T, Baselga J. Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2. Ann Oncol 25(12):2357-62, 12/2014. e-Pub 9/2014. PMID: 25231953.
39. Murthy RK, Theriault RL, Barnett CM, Hodge S, Ramirez MM, Milbourne A, Rimes SA, Hortobagyi GN, Valero V, Litton JK. Outcomes of children exposed in utero to chemotherapy for breast cancer. Breast Cancer Res 16(6). e-Pub 12/2014. PMID: 25547133.
40. Smerage JB, Barlow WE, Hortobagyi GN, Winer EP, Leyland-Jones B, Srkalovic G, Tejwani S, Schott AF, O'Rourke MA, Lew DL, Doyle GV, Gralow JR, Livingston RB, Hayes DF. Circulating Tumor Cells and Response to Chemotherapy in Metastatic Breast Cancer: SWOG S0500. Accompanied by an editorial: Bardia A, Haber DA: Solidifying Liquid Biopsies: Can Circulating Tumor Cell Monitoring Guide Treatment Selection in Breast Cancer? J Clin Oncol 32(31):3470-3472, 2014. doi: 10.1200/JCO.2014.57.1505. [Epub ahead of print on July 14, 2014] PMID:25024075. J Clin Oncol 32(31):3483-9, 11/2014. e-Pub 6/2014. PMCID: PMC4209100.
41. Partridge AH, Rumble RB, Carey LA, Come SE, Davidson NE, Di Leo A, Gralow J, Hortobagyi GN, Moy B, Yee D, Brundage SB, Danso MA, Wilcox M, Smith IE. Chemotherapy and Targeted Therapy for Women With Human Epidermal Growth Factor Receptor 2-Negative (or unknown) Advanced Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 32(29):3307-29, 10/2014. e-Pub 9/2014. PMID: 25185096.
42. Pusztai L, Moulder S, Altan M, Kwiatkowski D, Valero V, Ueno NT, Esteva FJ, Avritscher R, Qi Y, Strauss L, Hortobagyi GN, Hatzis C, Symmans WF. Gene signature-guided dasatinib therapy in metastatic breast cancer. Clin Cancer Res 20(20):5265-71, 10/2014. e-Pub 8/2014. PMID: 25172932.
43. Elsayegh N, Kuerer HM, Lin H, Gutierrez Barrera AM, Jackson M, Muse KI, Litton JK, Albarracin C, Afrough A, Hortobagyi GN, Arun BK. Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic Testing. Ann Surg Oncol 21(11):3466-72, 10/2014. e-Pub 5/2014. PMID: 24796968.
44. Giuliano M, Giordano A, Jackson S, De Giorgi U, Mego M, Cohen EN, Gao H, Anfossi S, Handy BC, Ueno NT, Alvarez RH, De Placido S, Valero V, Hortobagyi GN, Reuben JM, Cristofanilli M. Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination. Breast Cancer Res 16(5). e-Pub 9/2014. PMID: 25223629.
45. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res 74(17):4822-35, 9/2014. e-Pub 6/2014. PMCID: PMC4154991.
46. Yardley DA, Noguchi S, Pritchard KI, Burris HA, Baselga J, Gnant M, Hortobagyi GN, Campone M, Pistilli B, Piccart M, Melichar B, Petrakova K, Arena FP, Erdkamp F, Harb WA, Feng W, Cahana A, Taran T, Lebwohl D, Rugo HS. Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR(+) Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis. Adv Ther 31(9):1008-9, 9/2014. PMID: 25209875.
47. Hayashi N, Manyam GC, Gonzalez-Angulo AM, Niikura N, Yamauchi H, Nakamura S, Hortobágyi GN, Baggerly KA, Ueno NT. Reverse-phase protein array for prediction of patients at low risk of developing bone metastasis from breast cancer. Oncologist 19(9):909-14, 9/2014. e-Pub 8/2014. PMCID: PMC4153464.
48. Woodson AH, Muse KI, Lin H, Jackson M, Mattair DN, Schover L, Woodard T, McKenzie L, Theriault RL, Hortobágyi GN, Arun B, Peterson SK, Profato J, Litton JK. Breast cancer, BRCA mutations, and attitudes regarding pregnancy and preimplantation genetic diagnosis. Oncologist 19(8):797-804, 8/2014. e-Pub 6/2014. PMCID: PMC4122483.
49. Abouharb S, Ensor J, Loghin ME, Katz R, Moulder SL, Esteva FJ, Smith B, Valero V, Hortobagyi GN, Melhem-Bertrandt A. Leptomeningeal disease and breast cancer: the importance of tumor subtype. Breast Cancer Res Treat 146(3):477-86, 8/2014. e-Pub 7/2014. PMID: 25038877.
50. Murthy RK, Varma A, Mishra P, Hess KR, Young E, Murray JL, Koenig KH, Moulder SL, Melhem-Bertrandt A, Giordano SH, Booser D, Valero V, Hortobagyi GN, Esteva FJ. Effect of adjuvant/neoadjuvant trastuzumab on clinical outcomes in patients with HER2-positive metastatic breast cancer. Cancer 120(13):1932-8, 7/1/2014. e-Pub 3/26/2014. PMID: 24677057.
51. Barcenas CH, Niu J, Zhang N, Zhang Y, Buchholz TA, Elting LS, Hortobagyi GN, Smith BD, Giordano SH. Risk of Hospitalization According to Chemotherapy Regimen in Early-Stage Breast Cancer. J Clin Oncol 32(19):2010-7, 7/1/2014. e-Pub 5/27/2014. PMCID: PMC4164758.
52. Lee J, Bartholomeusz C, Mansour O, Humphries J, Hortobagyi GN, Ordentlich P, Ueno NT. A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression. Breast Cancer Res Treat 146(2):259-72, 7/2014. e-Pub 6/2014. PMCID: PMC4119423.
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116. Santarpia L, Iwamoto T, Di Leo A, Hayashi N, Bottai G, Stampfer M, André F, Turner NC, Symmans WF, Hortobágyi GN, Pusztai L, Bianchini G. DNA Repair Gene Patterns as Prognostic and Predictive Factors in Molecular Breast Cancer Subtypes. Oncologist 18(10):1063-73, 2013. e-Pub 9/2013. PMID: 24072219.
117. Hortobágyi G, Conte P. Interpreting cancer biology: refining our therapeutic algorithm in breast cancer. Oncologist 18(4):e8-e10, 2013. PMCID: PMC3639541.
118. Torikoshi Y, Gohda K, Davis ML, Symmans WF, Pusztai L, Kazansky A, Nakayama S, Yoshida T, Matsushima T, Hortobagyi GN, Ishihara H, Kim SJ, Noguchi S, Ueno NT. Novel functional assay for spindle-assembly checkpoint by cyclin-dependent kinase activity to predict taxane chemosensitivity in breast tumor patient. J Cancer 4(9):697-702, 2013. e-Pub 11/2013. PMCID: PMC3842438.
119. Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-Macgregor M. Use of ACE inhibitors and angiotensin receptor blockers and primary breast cancer outcomes. J Cancer 4(7):549-56, 2013. e-Pub 8/2013. PMCID: PMC3753529.
120. Meric-Bernstam F, Chen H, Akcakanat A, Do KA, Lluch A, Hennessy BT, Hortobagyi GN, Mills GB, Gonzalez-Angulo AM. Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer. Breast Cancer Res 14(5). e-Pub 10/2012. PMID: 23102376.
121. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of Body Mass Index on Survival Outcome among Women with Early Stage Triple-negative Breast Cancer. Clin Breast Cancer 12(5):364-72, 10/2012. PMID: 23040004.
122. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Incidence of Brain Metastases as a First Site of Recurrence Among Women with Triple Receptor-negative Breast Cancer. Cancer doi: 10.1002/cncr.27434(19):4652-9, 10/2012. e-Pub 2/2012. PMID: 22359359.
123. Cortés J, Calvo E, González-Martín A, Dawood S, Llombart-Cussac A, De Mattos-Arruda L, Gómez P, Silva O, Perez EA, Rugo HS, Lluch A, Hortobagyi GN. Progress against Solid Tumors in Danger: The Metastatic Breast Cancer Example. J Clin Oncol 30(28):3444-7, 10/2012. e-Pub 8/2012. PMID: 22927522.
124. Masuda H, Zhang D, Bartholomeusz C, Doihara H, Hortobagyi GN, Ueno NT. Role of epidermal growth factor receptor in breast cancer. Breast Cancer Res Treat 136(2). e-Pub 10/2012. PMID: 23073759.
125. Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKKβ/mTOR/VEGF Signaling Pathway as a Potential Therapeutic Strategy for Obesity-related Breast Cancer. Mol Cancer Ther 11(10):2212-21, 10/2012. e-Pub 7/2012. PMCID: PMC3712288.
126. Morrow PK, Murthy RK, Ensor JD, Gordon GS, Margolin KA, Elias AD, Urba WJ, Weng DE, Rugo HS, Hortobagyi GN. An Open-Label, Phase II Trial of RPI.4610 (Angiozyme) in the Treatment of Metastatic Breast Cancer. Cancer doi: 10.1002/cncr.26730(17):4098-104, 9/2012. e-Pub 1/2012. PMID: 22281842.
127. Wang Q, Li SH, Wang H, Xiao Y, Sahin O, Brady SW, Li P, Ge H, Jaffee EM, Muller WJ, Hortobagyi GN, Yu D. Concomitant Targeting of Tumor Cells and Induction of T Cell Response Synergizes to Effectively Inhibit Trastuzumab-resistant Breast Cancer. Cancer Res 72(17):4417-4428, 9/2012. e-Pub 7/2012. PMCID: PMC3556997.
128. Delpech Y, Wu Y, Hess KR, Hsu L, Ayers M, Natowicz R, Coutant C, Rouzier R, Barranger E, Hortobagyi GN, Mauro D, Pusztai L. Ki67 expression in the primary tumor predicts for clinical benefit and time to progression on first-line endocrine therapy in estrogen receptor-positive metastatic breast cancer. Breast Cancer Res Treat 135(2):619-27, 9/2012. e-Pub 8/2012. PMID: 22890751.
129. Lynch SP, Lei X, Chavez-MacGregor M, Hsu L, Meric-Bernstam F, Buchholz TA, Zhang A, Hortobagyi GN, Valero V, Gonzalez-Angulo AM. Multifocality and Multicentricity in Breast Cancer and Survival Outcomes. Ann Oncol 23(12). e-Pub 7/2012. PMID: 22776706.
130. Burstein HJ, Piccart-Gebhart MJ, Perez EA, Hortobagyi GN, Wolmark N, Albain KS, Norton L, Winer EP, Hudis CA. Choosing the Best Trastuzumab-Based Adjuvant Chemotherapy Regimen: Should We Abandon Anthracyclines? J Clin Oncol 30(18):2179-82, 6/20/2012. e-Pub 5/21/2012. PMID: 22614986.
131. Giordano SH, Lin YL, Kuo YF, Hortobagyi GN, Goodwin JS. Decline in the User of Anthracyclines for Breast Cancer. J Clin Oncol 30(18):2232-9, 6/20/2012. e-Pub 5/21/2012. PMCID: PMC3397719.
132. Moulder S, Gladish G, Ensor J, Gonzalez-Angulo AM, Cristofanilli M, Murray JL, Booser D, Giordano SH, Brewster A, Moore J, Rivera E, Hortobagyi GN, Tran HT. A phase 1 study of weekly everolimus (RAD001) in combination with docetaxel in patients with metastatic breast cancer. Cancer 118(9):2378-84, 5/2012. e-Pub 10/2011. PMID: 22006179.
133. Giordano A, Giuliano M, De Laurentiis M, Arpino G, Jackson S, Handy BC, Ueno NT, Andreopoulou E, Alvarez RH, Valero V, De Placido S, Hortobagyi GN, Reuben JM, Cristofanilli M. Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy. Ann Oncol 23(5):1144-50, 5/2012. e-Pub 9/2011. PMID: 21965473.
134. Bayraktar S, Gonzalez-Angulo AM, Lei X, Buzdar AU, Valero V, Melhem-Bertrandt A, Kuerer HM, Hortobagyi GN, Sahin AA, Meric-Bernstam F. Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and nonanthracycline-based regimens for HER2-positive breast cancer. Cancer 118(9):2385-93, 5/2012. e-Pub 9/2011. PMCID: PMC3274632.
135. Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M. Ganglioside GD2 Identifies Breast Cancer Stem Cells and Promotes Tumorigenesis. J Clin Invest pii: 59735. doi: 10.1172/JCI59735. e-Pub 5/2012. PMCID: PMC3591166.
136. Yamauchi H, Woodward WA, Valero V, Alvarez RH, Lucci A, Buchholz TA, Iwamoto T, Krishnamurthy S, Yang W, Reuben JM, Hortobagyi GN, Ueno NT. Inflammatory Breast Cancer: What We Know and What We Need to Learn. Oncologist 17(7). e-Pub 5/2012. PMID: 22584436.
137. De Giorgi U, Mego M, Scarpi E, Giuliano M, Giordano A, Reuben JM, Valero V, Ueno NT, Hortobagyi GN, Cristofanilli M. Relationship Between Lymphocytopenia and Circulating Tumor Cells as Prognostic Factors for Overall Survival in Metastatic Breast Cancer. Clin Breast Cancer 12(4). e-Pub 5/2012. PMID: 22591634.
138. Raghav KP, Wang W, Liu S, Chavez-MacGregor M, Meng X, Hortobagyi GN, Mills GB, Meric-Bernstam F, Blumenschein GR, Gonzalez-Angulo AM. cMET and phospho-cMET protein levels in breast cancers and survival outcomes. Clin Cancer Res 18(8):2269-77, 4/2012. e-Pub 2/2012. PMID: 22374333.
139. Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M. Identifying factors that impact survival among women with inflammatory breast cancer. Ann Oncol 23(4):870-5, 4/2012. e-Pub 7/2011. PMID: 21765048.
140. Santarpia L, Qi Y, Stemke-Hale K, Wang B, Young EJ, Booser DJ, Holmes FA, O'Shaughnessy J, Hellerstedt B, Pippen J, Vidaurre T, Gomez H, Valero V, Hortobagyi GN, Symmans WF, Bottai G, Di Leo A, Gonzalez-Angulo AM, Pusztai L. Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers. Breast Cancer Res Treat 134(1)(333-343). e-Pub 4/2012. PMID: 22538770.
141. Hayashi N, Nakamura S, Tokuda Y, Shimoda Y, Yagata H, Yoshida A, Ota H, Hortobagyi GN, Cristofanilli M, Ueno NT. Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer. Int J Clin Oncol 17(2):96-104, 4/2012. e-Pub 6/2011. PMID: 21671160.
142. Niikura N, Liu J, Hayashi N, Palla SL, Tokuda Y, Hortobagyi GN, Ueno NT, Theriault RL. Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone-only metastases. Cancer 118(8):2039-47, 4/2012. e-Pub 12/2011. PMID: 22139648.
143. Dutta B, Pusztai L, Qi Y, André F, Lazar V, Bianchini G, Ueno N, Agarwal R, Wang B, Shiang CY, Hortobagyi GN, Mills GB, Symmans WF, Balázsi G. A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes. Br J Cancer 106(6):1107-16, 3/2012. e-Pub 2/2012. PMCID: PMC3304402.
144. Morrow PK, Serna R, Broglio K, Pusztai L, Nikoloff DM, Hillman GR, Fontecha M, Li R, Michaud L, Hortobagyi G, Gonzalez-Angulo AM. Effect of CYP2D6 polymorphisms on breast cancer recurrence. Cancer 118(5):1221-7, 3/2012. e-Pub 8/2011. PMID: 21823108.
145. Bayraktar S, Hernadez-Aya LF, Lei X, Meric-Bernstam F, Litton JK, Hsu L, Hortobagyi GN, Gonzalez-Angulo AM. Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer 118(5):1202-11, 3/2012. e-Pub 7/2011. PMCID: PMC3207034.
146. Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN, Hung MC. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res 72(5):1290-300, 3/2012. e-Pub 1/2012. PMCID: PMC3350107.
147. Iwamoto T, Booser D, Valero V, Murray JL, Koenig K, Esteva FJ, Ueno NT, Zhang J, Shi W, Qi Y, Matsuoka J, Yang EJ, Hortobagyi GN, Hatzis C, Symmans WF, Pusztai L. Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry. J Clin Oncol 30(7):729-34, 3/2012. e-Pub 1/2012. PMID: 22291085.
148. Raghav KP, Hernandez-Aya LF, Lei X, Chavez-Macgregor M, Meric-Bernstam F, Buchholz TA, Sahin A, Do KA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of low estrogen/progesterone receptor expression on survival outcomes in breast cancers previously classified as triple negative breast cancers. Cancer 118(6):1498-506, 3/2012. e-Pub 8/2011. PMCID: PMC3217101.
149. Vahdat LT, Thomas ES, Roché HH, Hortobagyi GN, Sparano JA, Yelle L, Fornier MN, Martín M, Bunnell CA, Mukhopadhyay P, Peck RA, Perez EA. Ixabepilone-associated peripheral neuropathy: data from across the phase II and III clinical trials. Support Care Cancer 20(11). e-Pub 3/2012. PMID: 22382588.
150. Kelly CM, Green MC, Broglio K, Thomas ES, Brewster AM, Valero V, Ibrahim NK, Gonzalez-Angulo AM, Booser DJ, Walters RS, Hunt KK, Hortobagyi GN, Buzdar AU. Phase III Trial Evaluating Weekly Paclitaxel versus Docetaxel in Combination with Capecitabine in Operable Breast Cancer. J Clin Oncol 30(9):930-5, 3/2012. e-Pub 2/2012. PMID: 22331946.
151. Bayraktar S, Elsayegh N, Gutierrez Barrera AM, Lin H, Kuerer H, Tasbas T, Muse KI, Ready K, Litton J, Meric-Bernstam F, Hortobagyi GN, Albarracin CT, Arun B. Predictive factors for BRCA1/BRCA2 mutations in women with ductal carcinoma in situ. Cancer 118(6):1515-22, 3/2012. e-Pub 8/2011. PMID: 22009639.
152. Raghav KP, Wang W, Liu S, Chavez-MacGregor M, Meng X, Hortobagyi GN, Mills GB, Meric-Bernstam F, Blumenschein GR Jr. Gonzalez-Angulo AM. cMET and Phospho cMET Protein Levels in Breast Cancers and Survival Outcomes. Clin Cancer Res 18(8). e-Pub 2/2012. PMID: 22374333.
153. Schott AF, Barlow WE, Albain KS, Chew HK, Wade JL 3rd, Lanier KS, Lew DL, Hayes DF, Gralow JR, Livingston RB, Hortobagyi GN. Phase II Trial of Simple Oral Therapy with Capecitabine and Cyclophosphamide in Patients with Metastatic Breast Cancer: SWOG S0430. Oncologist 17(2):179-187, 2/2012. PMID: 22267853.
154. Gonzalez-Angulo AM, Iwamoto T, Liu S, Chen H, Do KA, Hortobagyi GN, Mills GB, Meric-Bernstam F, Symmans F, Pusztai L. Gene Expression, Molecular Class Changes and Pathway Analysis After Neoadjuvant Systemic Therapy for Breast Cancer. Clin Cancer Res 18(4). e-Pub 1/2012. PMID: 22235097.
155. Barcenas CH, Zhang N, Zhao H, Duan Z, Buchholz TA, Hortobagyi GN, Giordano SH. Anthracycline Regimen Adherence in Older Patients with Early Breast Cancer. Oncologist 17(3):303-311, 2012. e-Pub 2/27/2012. PMCID: PMC3316913.
156. Mehta RS, Barlow WE, Albain KS, Vandenberg TA, Dakhil SR, Tirumali NR, Lew DL, Hayes DF, Gralow JR, Livingston RB, Hortobagyi GN. Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer. N Engl J Med 367(5). e-Pub 2012. PMID: 22853014.
157. Bartholomeusz C, Gonzalez-Angulo AM, Liu P, Hayashi N, Lluch A, Ferrer-Lozano J, Hortobágyi GN. High ERK Protein Expression Levels Correlate with Shorter Survival in Triple-Negative Breast Cancer Patients. Oncologist 17(6):766-74, 2012. e-Pub 5/14/2012. PMCID: PMC3380875.
158. Mego M, Gao H, Lee BN, Cohen EN, Tin S, Giordano A, Wu Q, Liu P, Nieto Y, Champlin RE, Hortobagyi GN, Cristofanilli M, Ueno NT, Reuben JM. Prognostic Value of EMT-Circulating Tumor Cells in Metastatic Breast Cancer Patients Undergoing High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation. J Cancer 3:369-80, 2012. e-Pub 9/2012. PMID: 23074378.
159. Hortobagyi GN. Toward individualized breast cancer therapy: translating biological concepts to the bedside. Oncologist 17(4):577-84, 2012. e-Pub 4/2012. PMID: 22474069.
160. Hoff AO, Toth BB, Altundag K, Johnson MM, Warneke CL, Hu M, Nooka A, Sayegh G, Guarneri V, Desrouleaux K, Cui J, Adamus A, Gagel RF, Hortobagyi GN. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 23(6):826-36, 6/2008. PMID: 18558816.
161. Giordano SH, Kuo YF, Duan Z, Hortobagyi GN, Freeman J, Goodwin JS. Limits of observational data in determining outcomes from cancer therapy. Cancer 112(11):2456-66, 6/2008. PMID: 18428196.
162. Badgwell BD, Giordano SH, Duan ZZ, Fang S, Bedrosian I, Kuerer HM, Singletary SE, Hunt KK, Hortobagyi GN, Babiera G. Mammography before diagnosis among women age 80 years and older with breast cancer. J Clin Oncol 26(15):2482-8, 5/2008. PMID: 18427152.
163. Dawood S, Broglio K, Gong Y, Yang WT, Cristofanilli M, Kau SW, Meric-Bernstam F, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Gonzalez-Angulo AM. Prognostic significance of HER-2 status in women with inflammatory breast cancer. Cancer 112(9):1905-11, 5/2008. PMID: 18300243.
164. Srokowski TP, Fang S, Duan Z, Buchholz TA, Hortobagyi GN, Goodwin JS, Giordano SH. Completion of adjuvant radiation therapy among women with breast cancer. (Abstracted in Breast Diseases: A Year Book Quarterly 20(3):307-308, 2009. Cancer 113(1):22-29, 4/2008. PMID: 18442124.
165. Bristol IJ, Woodward WA, Strom EA, Cristofanilli M, Domain D, Singletary SE, Perkins GH, Oh JL, Yu TK, Terrefe W, Sahin AA, Hunt KK, Hortobagyi GN, Buchholz TA. Locoregional Treatment Outcomes After Multimodality Management Of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys, 4/2008. PMID: 18439768.
166. Tordai A, Wang J, Andre F, Liedtke C, Yan K, Sotiriou C, Hortobagyi GN, Symmans WF, Pusztai L. Evaluation of biological pathways involved in chemotherapy response in breast cancer. Breast Cancer Res 10(2):R37, 2008. PMID: 18445275.
167. Mazouni C, Hall A, Broglio K, Fritsche H, Andre F, Esteva FJ, Hortobagyi GN, Buzdar AU, Pusztai L, Cristofanilli M. Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy. Cancer 109:496-501, 2/2007. e-Pub 2/2007. PMID: 17149760.
168. Buzdar AU, Valero V, Ibrahim NK, Francis D, Broglio KR, Theriault RL, Pusztai L, Green MC, Singletary SE, Hunt KK, Sahin AA, Esteva F, Symmans WF, Ewer MS, Buchholz TA, Hortobagyi GN. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 13:228-33, 1/2007. PMID: 17200359.
169. Perez EA, Lerzo G, Pivot X, Thomas E, Vahdat L, Bosserman L, Viens P, Mukhopadhyay P, Mullaney B, Peck R, Hortobagyi GN. Efficacy and Safety of Ixabepilone (BMS-247550), a Novel Epothilone Analog, in a Phase II Study of Patients with Advanced Breast Cancer Resistant to and Anthracycline, a Taxane, and Capecitabine. J Clin Oncol 25(23):3407-3414, 2007. e-Pub 7/2007.
170. Gonzalez-Angulo AM, Sahin A, Krishnamurthy S, Yang Y, Kau SW, Hortobagyi GN, Cristofanilli M. Biologic markers in axillary node-negative breast cancer: differential expression in invasive ductal carcinoma versus invasive lobular carcinoma. Clin Breast Cancer 7:396-400, 12/2006. PMID: 17239264.
171. Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL, Hunt KK, Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 23(16):3676-85, 6/2005. PMID: 15738535.
172. Cristofanilli M, Gonzalez-Angulo A, Sneige N, Kau SW, Broglio K, Theriault RL, Valero V, Buzdar AU, Kuerer H, Buccholz TA, Hortobagyi GN. Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes. J Clin Oncol 23(1):41-8, 2005. PMID: 15625359.
173. Hortobagyi GN, Ueno NT, Xia W, Zhang S, Wolf JK, Putnam JB, Weiden PL, Willey JS, Carey M, Branham DL, Payne JY, Tucker SD, Bartholomeusz C, Kilbourn RG, De Jager RL, Sneige N, Katz RL, Anklesaria P, Ibrahim NK, Murray JL, Theriault RL, Valero V, Gershenson DM, Bevers MW, Huang L, Lopez-Berestein G, Hung MC. Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial. J Clin Oncol 19(14):3422-33, 7/2001. PMID: 11454891.
174. Hortobagyi GN, Buzdar AU, Theriault RL, Valero V, Frye D, Booser DJ, Holmes FA, Giralt S, Khouri I, Andersson B, Gajewski JL, Rondon G, Smith TL, Singletary SE, Ames FC, Sneige N, Strom EA, McNeese MD, Deisseroth AB, Champlin RE. Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma. J Natl Cancer Inst 92(3):225-33, 2/2000. PMID: 10655439.

Books (edited and written)

1. Stephens FO, Aigner KR, Aigner K, Allen-Mersh T, Hortobagyi G, Khayat D, Picksley SM, Sugarbaker P, Taguchi T, Thompson JF. Ed(s) Stephens FO, Aigner KR, Aigner K, Allen-Mersh T, Hortobagyi G, Khayat D, Picksley SM, Sugarbaker P, Taguchi T, Thompson JF. Basic of Oncology, 2nd Edition, 2nd. Springer Cham, Heidelberg: Germany, 2016. ISBN: ISBN: 978-3-319-23367-3; ISBN: 978-3-319-23368-0 (eBook).
2. Stephens FO, Aigner KR, Allen-Mersh T, Hortobagyi G, Khayat D, Picksley SM, Sugarbaker P, Taguchi T, Thompson JF. Ed(s) Stephens FO, Aigner KR, Allen-Mersh T, Hortobagyi G, Khayat D, Picksley SM, Sugarbaker P, Taguchi T, Thompson JF. Basic of Oncology, 1st Edition, 1st. Springer Press (Springer-Verlag): Berlin, 2009. ISBN: 10: 3-642-04072-1; 13: 978-3-642-04072-6; e-ISBN: 978-3-540-92925-3.
3. Singletary SE, Robb GL, Hortobagyi GN. Ed(s) Singletary SE, Robb GL, Hortobagyi GN (Chinese edition, Drs. Ning and Fang [Eds.]). Advanced Therapy of Breast Disease, 2nd Edition, 2nd. People’s Medical Publishing House: Beijing, 2007. ISBN: 978-7-117-08442-0/R-8443.


1. Guidelines. Barcenas C, Bedrosian I, Bevers TB, Hortobagyi GN, Moulder S, Tereffe W, Yang WT, Zandstra F: Survivorship – Noninvasive Breast Cancer©. The University of Texas MD Anderson Cancer Center – Department of Clinical Effectiveness. July 29, 2014.
2. Guidelines.

Bevers TB, Barcenas C, Bedrosian I, Hortobagyi GN, Moulder S, Tereffe W, Yang WT, Zandstra F: Survivorship – Invasive Breast Cancer©. The University of Texas MD Anderson Cancer Center – Department of Clinical Effectiveness. July 29, 2014.

3. Guidelines. Bedrosian I, Bevers TB, Bowe C, Gagel RF, Green MC, Hortobagyi GN, Hu MI-N, Bertrandt AM, Sherman SI, Strom EA, Zandstra F: Breast Cancer Survivorship: Bone Health©. The University of Texas MD Anderson Cancer Center – Department of Clinical Effectiveness. July 29, 2014.

Grant & Contract Support

Title: Revising AJCC TNM Breast Cancer Staging: Analyzing National Datasets
Funding Source: The Breast Cancer Research Foundation (#15122133)
Role: Principal Investigator
Duration: 10/1/2015 - 9/30/2016
Funding Source: National Cancer Institute - Southwest Oncology Group – Oregon Health & Science University
Role: Breast Cancer Committee Chairman
Duration: 3/1/2015 - 2/28/2016
Title: Cancer Prevention Agent Development Program: Early Phase Clinical Research
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: P. Brown
Duration: 9/24/2013 - 9/23/2013
Title: Cancer Center Support (Core) Grant-Project 6-Breast Cancer Program
Funding Source: DHHS/NIH/NCI
Role: Principal Investigator
Duration: 7/1/2013 - 6/30/2018
Title: Breast Cancer Committee Chairman
Funding Source: NCI/Southwest Oncology Group/University of Michigan
Role: Principal Investigator
Duration: 1/1/2013 - 12/31/2013
Title: U10 Full Member Application Affiliated with SWOG
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: S. Lippman
Duration: 12/1/2010 - 12/1/2015
Title: Development of Novel Strategies of Early Detection and Prevention for HER2+, ER-negative Breast Cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Co-Investigator
Principal Investigator: D. Yu
Duration: 9/15/2009 - 9/14/2014
Title: Susan G. Komen for the Cure Promise Grant: Development of Novel Early Detection and Prevention Strategies for ER Negative Breast Cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Investigator
Principal Investigator: D. Yu
Duration: 5/15/2009 - 5/14/2014
Title: Rare and Aggressive Breast Cancer Research Program
Funding Source: State of Texas
Role: Principal Investigator
Duration: 9/1/2007 - 8/31/2013

Last updated: 4/8/2016