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George A Calin, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Dr. Calin's main research interests are: 1) the involvementof non-coding RNAs in human diseases in general and of microRNAs in humancancers in particular, 2) the study of familial predisposition to humancancers, 3) the identification of ncRNA biomarkers in body fluids, and 4) thedevelopment of new RNA-basedtherapeutic options for cancer patients.

Please visit the Calin Lab.

Education & Training

Degree-Granting Education

2000 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, PHD, Faculty of Medicine
1992 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, MD, Faculty of Medicine

Honors and Awards

2014-present Highly Cited Researchers, Thomson Reuters
2013 2013 Celegene Awards for Clinical Research in Hematology, Celegene
2013 2013 Julie and Ben Rogers Award for Excellence in the Area of Research
2012 Potu N. Rao Award for Excellence in Basic Science, Division of Cancer Medicine Faculty Excellence Awards, The University of Texas MD Anderson Cancer Center
2011-2016 The Alan M. Gerwitz Leukemia & Lymphoma Society Scholar, Leukemia & Lymphoma Society Society
2007-present Fellow of The University of Texas MD Anderson Research Trust, The University of Texas MD Anderson Cancer Center
2007-present The University of Texas System Regents' Research Scholar Program Award Recipient, The University of Texas MD Anderson Cancer Center
2004-2006 Kimmel Foundation Scholar, Kimmel Foundation
1998-1999 International Research Training Fellowship, The International Agency for Research on Cancer (Lyon), University of Ferrara, Italy
1997-1998 The Yamagiwa-Yoshida memorial International Cancer Study Grant, The International Union Against Cancer (Geneva), University of Ferrara, Italy
1988 Award at the National Competition on Human Physiology, Romania
1987 Award at the National Competition on Human Anatomy, Romania
1985 Award at the National Competition on Human Anatomy, Romania

Selected Publications

Peer-Reviewed Original Research Articles

1. Li X, Liu Y, Granberg KJ, Wang Q, Moore LM, Ji P, Gumin J, Sulman EP, Calin GA, Haapasalo H, Nykter M, Shmulevich I, Fuller GN, Lang FF, Zhang W. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene 34(13):1619-28, 3/26/2015. e-Pub 4/21/2014. PMCID: PMC4205227.
2. Zhang S, Lu Z, Unruh AK, Ivan C, Baggerly KA, Calin GA, Li Z, Bast RC, Le XF. Clinically Relevant microRNAs in Ovarian Cancer. Mol Cancer Res 13(3):393-401, 3/2015. e-Pub 10/10/2014. PMCID: PMC4369176.
3. Zuo Z, Maiti S, Hu S, Loghavi S, Calin GA, Garcia-Manero G, Kantarjian HM, Medeiros LJ, Cooper LJ, Bueso-Ramos CE. Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes. Mod Pathol 28(3):373-82, 3/2015. e-Pub 9/12/2014. PMID: 25216221.
4. Van Roosbroeck K, Verstovsek S, Calin GA. Long non-coding rnas in primary myelofibrosis: the dark matter in hematopoietic progenitor cells? Leuk Lymphoma 56(2):1-6, 2/2015. e-Pub 8/5/2014. PMID: 25093380.
5. Braicu C, Tomuleasa C, Monroig P, Cucuianu A, Berindan-Neagoe I, Calin GA. Exosomes as divine messengers: are they the Hermes of modern molecular oncology? Cell Death Differ 22(1):34-45, 1/2015. e-Pub 9/19/2014. PMCID: PMC4262777.
6. Monroig Pdel C, Chen L, Zhang S, Calin GA. Small molecule compounds targeting miRNAs for cancer therapy. Adv Drug Deliv Rev 81:104-16, 1/2015. e-Pub 9/17/2014. PMCID: PMC4461213.
7. Sato-Kuwabara Y, Melo SA, Soares FA, Calin GA. The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review). Int J Oncol 46(1):17-27, 1/2015. e-Pub 10/17/2014. PMCID: PMC4238728.
8. Kunej T, Obsteter J, Pogacar Z, Horvat S, Calin GA. The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring. Crit Rev Clin Lab Sci 51(6):344-57, 12/2014. e-Pub 8/15/2014. PMID: 25123609.
9. Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. Cancer Cell 26(5):707-21, 11/10/2014. e-Pub 10/23/2014. PMCID: PMC4254633.
10. Bottai G, Pasculli B, Calin GA, Santarpia L. Targeting the microRNA-regulating DNA damage/repair pathways in cancer. Expert Opin Biol Ther 14(11):1-17, 11/2014. e-Pub 9/5/2014. PMID: 25190496.
11. Gee HE, Ivan C, Calin GA, Ivan M. HypoxamiRs and Cancer: From Biology to Targeted Therapy. Antioxid Redox Signal 21(8):1220-38, 9/10/2014. e-Pub 11/22/2013. PMCID: PMC4142802.
12. Ress AL, Stiegelbauer V, Schwarzenbacher D, Deutsch A, Perakis S, Ling H, Ivan C, Calin GA, Rinner B, Gerger A, Pichler M. Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer. Oncotarget 5(18):8492-502, 9/30/2014. PMCID: PMC4226699.
13. Berindan-Neagoe I, Monroig Pdel C, Pasculli B, Calin GA. MicroRNAome genome: a treasure for cancer diagnosis and therapy. CA Cancer J Clin 64(5):311-36, Sep-Oct, 9/2014. e-Pub 8/7/2014. PMCID: PMC4461198.
14. Giza DE, Vasilescu C, Calin GA. MicroRNAs and ceRNAs: therapeutic implications of RNA networks. Expert Opin Biol Ther 14(9):1285-93, 9/2014. e-Pub 6/18/2014. PMID: 24941322.
15. Negrini M, Cutrona G, Bassi C, Fabris S, Zagatti B, Colombo M, Ferracin M, D'Abundo L, Saccenti E, Matis S, Lionetti M, Agnelli L, Gentile M, Recchia AG, Bossio S, Reverberi D, Rigolin G, Calin GA, Sabbioni S, Russo G, Tassone P, Morabito F, Ferrarini M, Neri A. microRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters. Clin Cancer Res 20(15):4141-53, 8/1/2014. e-Pub 6/10/2014. PMID: 24916701.
16. Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst 106(8), 8/2014. e-Pub 6/28/2014. PMCID: PMC4271080.
17. Cortez MA, Valdecanas D, Zhang X, Zhan Y, Bhardwaj V, Calin GA, Komaki R, Giri DK, Quini CC, Wolfe T, Peltier HJ, Bader AG, Heymach JV, Meyn RE, Welsh JW. Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer. Mol Ther 22(8):1494-503, 8/2014. e-Pub 5/5/2014. PMID: 24791940.
18. Cui B, Chen L, Zhang S, Mraz M, Fecteau JF, Yu J, Ghia EM, Zhang L, Bao L, Rassenti LZ, Messer K, Calin GA, Croce CM, Kipps TJ. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood 124(4):546-54, 7/24/2014. e-Pub 6/9/2014. PMCID: PMC4110661.
19. Liz J, Portela A, Soler M, Gómez A, Ling H, Michlewski G, Calin GA, Guil S, Esteller M. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region. Mol Cell 55(1):138-47, 7/3/2014. e-Pub 6/5/2014. PMID: 24910097.
20. Kita Y, Vincent K, Natsugoe S, Berindan-Neagoe I, Calin GA. Epigenetically regulated microRNAs and their prospect in cancer diagnosis. Expert Rev Mol Diagn 14(6):673-83, 7/2014. e-Pub 6/10/2014. PMID: 24914586.
21. Pichler M, Calin GA. Long noncoding RNA in neuroblastoma: new light on the (old) N-Myc story. J Natl Cancer Inst 106(7), 7/2014. e-Pub 6/6/2014. PMID: 24906400.
22. Shah MY, Calin GA. MicroRNAs as therapeutic targets in human cancers. Wiley Interdiscip Rev RNA 5(4):537-48, Jul-Aug, 7/2014. e-Pub 3/28/2014. PMID: 24687772.
23. Wu SY, Lopez-Berestein G, Calin GA, Sood AK. RNAi therapies: drugging the undruggable. Sci Transl Med 6(240):240ps7, 6/11/2014. PMCID: PMC4154139.
24. Ferreira AF, Moura LG, Tojal I, Ambrósio L, Pinto-Simões B, Hamerschlak N, Calin GA, Ivan C, Covas DT, Kashima S, Castro FA. ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance. Blood Cells Mol Dis 53(1-2):47-55, Jun-Aug, 6/2014. e-Pub 3/11/2014. PMID: 24629639.
25. Liu X, Robinson SN, Setoyama T, Tung SS, D'Abundo L, Shah MY, Yang H, Yvon E, Shah N, Yang H, Konopleva M, Garcia-Manero G, McNiece I, Rezvani K, Calin GA, Shpall EJ, Parmar S. FOXP3 is a direct target of miR15a/16 in umbilical cord blood regulatory T cells. Bone Marrow Transplant 49(6):793-9, 6/2014. e-Pub 4/7/2014. PMCID: PMC4080423.
26. Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T, Calin GA. Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol 65(6):1140-51, 6/2014. e-Pub 12/14/2013. PMID: 24373479.
27. Rayner K, Dimmeler S, Calin GA, Thum T, Raizman JE, Diamandis EP. Novel biomarkers for acute myocardial infarction: is microRNA the new kid on the block? Clin Chem 60(6):812-7, 6/2014. e-Pub 11/8/2013. PMID: 24212084.
28. Armenia J, Fabris L, Lovat F, Berton S, Segatto I, D'Andrea S, Ivan C, Cascione L, Calin GA, Croce CM, Colombatti A, Vecchione A, Belletti B, Baldassarre G. Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. Oncotarget 5(5):1185-97, 3/15/2014. PMCID: PMC4012735.
29. Pichler M, Ress AL, Winter E, Stiegelbauer V, Karbiener M, Schwarzenbacher D, Scheideler M, Ivan C, Jahn SW, Kiesslich T, Gerger A, Bauernhofer T, Calin GA, Hoefler G. MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients. Br J Cancer 110(6):1614-21, 3/18/2014. e-Pub 2/6/2014. PMCID: PMC3960623.
30. Schwarzenbach H, Nishida N, Calin GA, Pantel K. Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol 11(3):145-56, 3/2014. e-Pub 2/4/2014. PMID: 24492836.
31. Zhou Y, Wan G, Spizzo R, Ivan C, Mathur R, Hu X, Ye X, Lu J, Fan F, Xia L, Calin GA, Ellis LM, Lu X. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol 8(1):83-92, 2/2014. e-Pub 10/8/2013. PMCID: PMC4124530.
32. Maia BM, Rocha RM, Calin GA. Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: challenges and opportunities in oncology. Epigenetics 9(1):75-80, 1/2014. e-Pub 10/11/2013. PMCID: PMC3928188.
33. Silla T, Kepp K, Tai ES, Goh L, Davila S, Catela Ivkovic T, Calin GA, Voorhoeve PM. Allele frequencies of variants in ultra conserved elements identify selective pressure on transcription factor binding. PLoS One 9(11):e110692, 2014. e-Pub 11/4/2014. PMCID: PMC4219694.
34. Anfossi S, Giordano A, Gao H, Cohen EN, Tin S, Wu Q, Garza RJ, Debeb BG, Alvarez RH, Valero V, Hortobagyi GN, Calin GA, Ueno NT, Woodward WA, Reuben JM. High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of favorable clinical outcome in patients with metastatic HER2+ inflammatory breast cancer. PLoS One 9(1):e83113, 2014. e-Pub 1/8/2014. PMCID: PMC3885405.
35. Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun 5:5202, 2014. e-Pub 10/29/2014. PMCID: PMC4215647.
36. Bottoni A, Calin GA. MicroRNAs as Main Players in the Pathogenesis of Chronic Lymphocytic Leukemia. Microrna 2(3):158-64, 2014. PMID: 25069439.
37. Crippa E, Lusa L, De Cecco L, Marchesi E, Calin GA, Radice P, Manoukian S, Peissel B, Daidone MG, Gariboldi M, Pierotti MA. miR-342 regulates BRCA1 expression through modulation of ID4 in breast cancer. PLoS One 9(1):e87039, 2014. e-Pub 1/27/2014. PMCID: PMC3903605.
38. Nassar FJ, El Sabban M, Zgheib NK, Tfayli A, Boulos F, Jabbour M, El Saghir NS, Talhouk R, Bazarbachi A, Calin GA, Nasr R. miRNA as potential biomarkers of breast cancer in the Lebanese population and in young women: a pilot study. PLoS One 9(9):e107566, 2014. e-Pub 9/18/2014. PMCID: PMC4169426.
39. Braicu C, Catana C, Calin GA, Berindan-Neagoe I. NCRNA Combined Therapy as Future Treatment Option for Cancer. Curr Pharm Des 20(42):6565-74, 2014. PMID: 25341933.
40. Ru Y, Kechris KJ, Tabakoff B, Hoffman P, Radcliffe RA, Bowler R, Mahaffey S, Rossi S, Calin GA, Bemis L, Theodorescu D. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res 42(17):e133, 2014. e-Pub 7/24/2014. PMCID: PMC4176155.
41. Santarpia L, Calin GA, Adam L, Ye L, Fusco A, Giunti S, Thaller C, Paladini L, Zhang X, Jimenez C, Trimarchi F, El-Naggar AK, Gagel RF. A miRNA signature associated with human metastatic medullary thyroid carcinoma. Endocr Relat Cancer 20(6):809-23, 12/2013. e-Pub 10/14/2013. PMID: 24127332.
42. Ferdin J, Nishida N, Wu X, Nicoloso MS, Shah MY, Devlin C, Ling H, Shimizu M, Kumar K, Cortez MA, Ferracin M, Bi Y, Yang D, Czerniak B, Zhang W, Schmittgen TD, Voorhoeve MP, Reginato MJ, Negrini M, Davuluri RV, Kunej T, Ivan M, Calin GA. HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts. Cell Death Differ 20(12):1675-87, 12/2013. e-Pub 9/13/2013. PMCID: PMC3824588.
43. Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 12(11):847-65, 11/2013. PMID: 24172333.
44. Nishimura M, Jung EJ, Shah MY, Lu C, Spizzo R, Shimizu M, Han HD, Ivan C, Rossi S, Zhang X, Nicoloso MS, Wu SY, Almeida MI, Bottsford-Miller J, Pecot CV, Zand B, Matsuo K, Shahzad MM, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Calin GA. Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discov 3(11):1302-15, 11/2013. e-Pub 9/3/2013. PMCID: PMC3855315.
45. Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J 32(21):2833-47, 10/30/2013. e-Pub 10/4/2013. PMCID: PMC3817469.
46. Manyam G, Ivan C, Calin GA, Coombes KR. targetHub: a programmable interface for miRNA-gene interactions. Bioinformatics 29(20):2657-8, 10/15/2013. e-Pub 9/6/2013. PMCID: PMC3789542.
47. Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, Zhang X, de Weerd V, Shimizu M, Ling H, Buiga R, Pop V, Irimie A, Fodde R, Bedrosian I, Martens JW, Foekens JA, Berindan-Neagoe I, Calin GA. CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget 4(10):1748-62, 10/2013. PMCID: PMC3858561.
48. Nishida N, Mimori K, Mori M, Calin GA. EGFR gets in the way of microRNA biogenesis. Cell Res 23(10):1157-8, 10/2013. e-Pub 7/9/2013. PMCID: PMC3790241.
49. Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B-chronic lymphocytic leukemia. Blood 122(11):1891-9, 9/12/2013. e-Pub 7/2/2013. PMCID: PMC3779381.
50. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 23(9):1446-61, 9/2013. e-Pub 6/24/2013. PMCID: PMC3759721.
51. Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, Pickering CR, Kupferman ME, Myers JN, Calin GA, Lai SY. Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Oncotarget 4(9):1388-98, 9/2013. PMCID: PMC3824521.
52. Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, Yang Y, McEnery K, Jethwa K, Gjyshi O, Qiao W, Levine NB, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res 73(13):3913-26, 7/1/2013. e-Pub 5/1/2013. PMCID: PMC3780786.
53. Jin L, Wessely O, Marcusson EG, Ivan C, Calin GA, Alahari SK. Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/Neu, EGF, and TNF-α in Breast Cancer. Cancer Res 73(9):2884-96, 5/1/2013. e-Pub 1/21/2013. PMCID: PMC3855090.
54. Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R. Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation. PLoS Genet 9(5):e1003424, 5/2013. e-Pub 5/2/2013. PMCID: PMC3642041.
55. Monroig PD, Calin GA. MicroRNA and Epigenetics: Diagnostic and Therapeutic Opportunities. Curr Pathobiol Rep 1(1):43-52, 3/2013. PMCID: PMC3600114.
56. Van Roosbroeck K, Pollet J, Calin GA. miRNAs and long noncoding RNAs as biomarkers in human diseases. Expert Rev Mol Diagn 13(2):183-204, 3/2013. PMID: 23477558.
57. Tsongalis GJ, Calin G, Cordelier P, Croce C, Monzon F, Szafranska-Schwarzbach AE. MicroRNA Analysis: Is It Ready for Prime Time? Clin Chem 59(2):343-7, 2/2013. e-Pub 8/30/2012. PMID: 22935643.
58. Shah MY, Calin GA. The Mix of Two Worlds: Non-Coding RNAs and Hormones. Nucleic Acid Ther 23(1):2-8, 2/2013. e-Pub 10/10/2012. PMCID: PMC3569955.
59. Vasilescu C, Olteanu M, Flondor P, Calin GA. Fractal-like kinetics of intracellular enzymatic reactions: a chemical framework of endotoxin tolerance and a possible non-specific contribution of macromolecular crowding to cross-tolerance. Theor Biol Med Model 10:55, 2013. e-Pub 9/14/2013. PMCID: PMC3849556.
60. Godnic I, Zorc M, Jevsinek Skok D, Calin GA, Horvat S, Dovc P, Kovac M, Kunej T. Genome-wide and species-wide in silico screening for intragenic MicroRNAs in human, mouse and chicken. PLoS One 8(6):e65165, 2013. e-Pub 6/6/2013. PMCID: PMC3675212.
61. Braicu C, Calin GA, Berindan-Neagoe I. MicroRNAs and Cancer Therapy - from Bystanders to Major Players. Curr Med Chem 20(29):3561-73, 2013. e-Pub 6/25/2013. PMID: 23834177.
62. Rozovski U, Calin GA, Setoyama T, D'Abundo L, Harris DM, Li P, Liu Z, Grgurevic S, Ferrajoli A, Faderl S, Burger JA, O'Brien S, Wierda WG, Keating MJ, Estrov Z. Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells. Mol Cancer 12:50, 2013. e-Pub 6/1/2013. PMCID: PMC3671957.
63. Li P, Grgurevic S, Liu Z, Harris D, Rozovski U, Calin GA, Keating MJ, Estrov Z. Signal transducer and activator of transcription-3 induces MicroRNA-155 expression in chronic lymphocytic leukemia. PLoS One 8(6):e64678, 2013. e-Pub 6/4/2013. PMCID: PMC3672147.
64. Hudson RS, Yi M, Volfovsky N, Prueitt RL, Esposito D, Volinia S, Liu CG, Schetter AJ, Van Roosbroeck K, Stephens RM, Calin GA, Croce CM, Ambs S. Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer 12:13, 2013. e-Pub 2/14/2013. PMCID: PMC3626580.
65. Chen L, Calin G, Zhang S. Novel Insights of Structure-based Modeling for RNA-targeted Drug Discovery. J Chem Inf Model. e-Pub 9/4/2012. PMCID: PMC3869234.
66. Redis RS, Calin S, Yang Y, You MJ, Calin GA. Cell-to-cell miRNA transfer: From body homeostasis to therapy. Pharmacol Ther. e-Pub 8/8/2012. PMCID: PMC3855335.
67. Calin GA, Konopleva M. Small gene, big number, many effects. Blood 120(2):240-1, 7/12/2012. PMCID: PMCN/A.
68. Almeida MI, Reis RM, Calin GA. Decoy activity through microRNAs: the therapeutic implications. Expert Opin Biol Ther. e-Pub 6/1/2012. PMCID: PMC3799811.
69. Lin M, Gu J, Eng C, Ellis LM, Hildebrandt MA, Lin J, Huang M, Calin GA, Wang D, Dubois RN, Hawk ET, Wu X. Genetic Polymorphisms in MicroRNA-Related Genes as Predictors of Clinical Outcomes in Colorectal Adenocarcinoma Patients. Clin Cancer Res. e-Pub 6/27/2012. PMCID: PMC4141857.
70. Jung EJ, Santarpia L, Kim J, Esteva FJ, Moretti E, Buzdar AU, Di Leo A, Le XF, Bast RC, Park ST, Pusztai L, Calin GA. Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. Cancer 118(10):2603-14, 5/15/2012. e-Pub 10/5/2011. PMCID: PMC3864019.
71. Kunej T, Godnic I, Horvat S, Zorc M, Calin GA. Cross Talk Between MicroRNA and Coding Cancer Genes. Cancer J 18(3):223-31, 5/2012. PMCID: PMC3389046.
72. Redis RS, Berindan-Neagoe I, Pop VI, Calin GA. Non-coding RNAs as theranostics in human cancers. J Cell Biochem 113(5):1451-9, 5/2012. e-Pub 12/28/2011. PMCID: PMC3337365.
73. Bhayani MK, Calin GA, Lai SY. Functional relevance of miRNA sequences in human disease. Mutat Res 731(1-2):14-9, 3/1/2012. e-Pub 11/6/2011. PMCID: PMCN/A.
74. Zhang P, Bill K, Liu J, Young E, Peng T, Bolshakov S, Hoffman A, Song Y, Demicco EG, Terrada DL, Creighton CJ, Anderson ML, Lazar AJ, Calin GG, Pollock RE, Lev D. MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1α and Enhances β-Catenin Signaling. Cancer Res. e-Pub 3/23/2012. PMCID: PMC3319789.
75. Spizzo R, Almeida MI, Colombatti A, Calin GA. Long non-coding RNAs and cancer: a new frontier of translational research? Oncogene. e-Pub 1/23/2012. PMCID: PMC3433647.
76. Rivetti di Val Cervo P, Lena AM, Nicoloso M, Rossi S, Mancini M, Zhou H, Saintigny G, Dellambra E, Odorisio T, Mahé C, Calin GA, Candi E, Melino G. p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A 109(4):1133-8, 1/24/2012. e-Pub 1/6/2012. PMCID: PMC3268329.
77. Zorc M, Skok DJ, Godnic I, Calin GA, Horvat S, Jiang Z, Dovc P, Kunej T. Catalog of microRNA seed polymorphisms in vertebrates. PLoS One 7(1):e30737, 1/2012. PMCID: PMC3267754.
78. Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, Gafà R, Xiao L, Zhang X, Vannini I, Fanini F, Fabbri M, Lanza G, Reis RM, Zweidler-McKay PA, Calin GA. Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells. Gastroenterology. e-Pub 1/2012. PMCID: PMC3321100.
79. Cortez MA, Welsh JW, Calin GA. Circulating microRNAs as noninvasive biomarkers in breast cancer. Recent Results Cancer Res 195:151-61, 2012. PMCID: PMC3855311.
80. Le XF, Almeida MI, Mao W, Spizzo R, Rossi S, Nicoloso MS, Zhang S, Wu Y, Calin GA, Bast RC. Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer. PLoS One 7(7):e41170, 2012. e-Pub 7/19/2012. PMCID: PMC3400637.
81. Rossi S, Tsirigos A, Amoroso A, Mascellani N, Rigoutsos I, Calin GA, Volinia S. OMiR: Identification of associations between OMIM diseases and microRNAs. Genomics 97(2):71-6, 2/2011. e-Pub 10/2010. PMID: 20974243.
82. Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA 305(1):59-67, 1/2011. PMCID: PMC3690301.
83. Rossi S, Shimizu M, Barbarotto E, Nicoloso MS, Dimitri F, Sampath D, Fabbri M, Lerner S, Barron LL, Rassenti LZ, Jiang L, Xiao L, Hu J, Secchiero P, Zauli G, Volinia S, Negrini M, Wierda W, Kipps TJ, Plunkett W, Coombes KR, Abruzzo LV, Keating MJ, Calin GA. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood 116(6):945-52, 8/12/2010. e-Pub 4/14/2010. PMID: 20393129.
84. Nicoloso MS, Sun H, Spizzo R, Kim H, Wickramasinghe P, Shimizu M, Wojcik SE, Ferdin J, Kunej T, Xiao L, Manoukian S, Secreto G, Ravagnani F, Wang X, Radice P, Croce CM, Davuluri RV, Calin GA. Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res 70(7):2789-98, 4/2010. e-Pub 3/2010. PMCID: PMC2853025.
85. Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu S, Schwind S, Santhanam R, Hickey CJ, Becker H, Chandler JC, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Liebhaber SA, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 140(5):652-65, 3/2010. PMID: 20211135.
86. Spizzo R, Nicoloso M, Croce CM, Calin GA. Snap Shot: MicroRNAs in Cancer. Cell 137(3):586-586.e1, 5/2009. PMID: 19410551.
87. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs - the micro steering wheel of tumour metastases. Nat Rev Cancer 9(4), 4/2009. e-Pub 3/2009. PMID: 19262572.
88. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 105(13):5166-71, Jan-Feb, 4/2008. PMID: 18362358.
89. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299(4):425-36, Jan-Feb, 1/2008. PMID: 18230780.
90. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12(3):215-29, 9/2007. PMID: 17785203.
91. Calin GA, Croce CM. MicroRNa signatures in human cancers. Nat Rev Cancer 6(11):857-66, 11/2006. PMID: 17060945.
92. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103(7):2257-61, 2/2006. e-Pub 2/2006. PMID: 16461460.
93. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353(17):1793-801, 10/2005. PMID: 16251535.
94. Calin GA, Trapasso F, Shimizu M, Dumitru CD, Yendamuri S, Godwin AK, Ferracin M, Bernardi G, Chatterjee D, Baldassarre G, Rattan S, Alder H, Mabuchi H, Shiraishi T, Hansen LL, Overgaard J, Herlea V, Mauro FR, Dighiero G, Movsas B, Rassenti L, Kipps T, Baffa R, Fusco A, Mori M, Russo G, Liu CG, Neuberg D, Bullrich F, Negrini M, Croce CM. Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med 352(16):1667-76, 4/2005. PMID: 15843669.
95. Liu CG, Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Zupo S, Dono M, Alder H, Bullrich F, Negrini M, Croce CM. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A 101(26):9740-4, 6/2004. e-Pub 6/2004. PMID: 15210942.
96. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99(24):15524-9, 11/2002. PMID: 12434020.

Book Chapters

1. Ling H, Calin GA. MicroRNAs as drugs and drug targets. In: Translational Oncology: Cancer Gene Therapy by Viral and Non-viral Vectors. Ed(s) Malcolm K. Brenner and Mien-Chie Hung. John Wiley & Sons, Inc., 2014.
2. Ling H, Calin GA. The role of microRNAs and ultraconserved non-coding RNAs in cancer. In: Cancer Genomics: From Bench to Personalized Medicine. Ed(s) Graham Dellaire, Jason N Berman, Robert J. Arceci. Academic Press/Elsevier, 2014.
3. Rossi S, Calin GA. Bioinformatics, non-coding RNAs and its possible application in personalized medicine. In: Adv Exp Med Biol. 774. Springer, 21-37, 2013. ISBN: 23377966.
4. Fabbri M, Calore F, Paone A, Galli R, Calin GA. Epigenetic regulation of miRNAs in cancer. In: Adv Exp Med Biol. 754. Springer, New York, 137-48, 2013. ISBN: 22956499.
5. Fabbri M, Calin G. Noncoding RNAs: Identification of Cancer-Associated microRNAs. In: RNA Technologies (Springer series) From Nucleic Acids Sequences to Molecular Medicine. Springer, 2012.

Grant & Contract Support

Title: A combined ‘miRNA-miRNA’ therapy for primary glioblastomas (GBM)
Funding Source: UTMDACC Brain SPORE
Role: Principal Investigator
Duration: 9/1/2015 - 8/31/2016
Title: Exosome-mediated long non-codingRNA crosstalk during stem cell differentiation
Funding Source: National Science Foundation (NSF)
Role: Principal Investigator
Duration: 7/1/2015 - 6/30/2020
Title: The Role and Therapeutic Potential of Novel ncRNA
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Ozpolat
Duration: 7/1/2015 - 6/30/2020
Title: Molecular signatures of meat derived nutri-miRs and their impact in consumer's diet
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2015 - 6/30/2020
Title: Long non-coding RNA regulation of chromosomal instability: mechanisms and applications
Funding Source: The University of Texas MD Anderson Cancer Center - Knowledge GAP
Role: Principal Investigator
Duration: 9/1/2014 - 8/31/2015
Title: The role of epigenetically regulated long non-coding RNAs in colorectal carcinogenesis
Funding Source: The University of Texas MD Anderson Cancer Center - Center for Cancer Epigenetics
Role: Principal Investigator
Duration: 9/1/2014 - 8/31/2015
Title: Novel microRNA-based combinatorial RNA inhibition therapy
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 8/31/2014 - 8/30/2017
Title: Protein-coding and non-coding RNA biomarkers for early detection of CLL
Funding Source: NIH/NCI
Role: Multiple PI
Duration: 6/1/2014 - 5/31/2019
Title: Non-coding RNAS in radioresistance of human cancer
Funding Source: UTMDACC Center for Radiation Oncology Research
Role: Principal Investigator-MDACC
Duration: 3/1/2014 - 2/28/2015
Title: Role of MIRNAS in T-ALL
Funding Source: UTMDACC Center for Genetics and Genomics
Role: Collaborator
Principal Investigator: You
Duration: 9/1/2013 - 8/31/2014
Title: Novel extra cellular RNA-based combinatorial RNA inhibition therapy
Funding Source: NIH/NCI
Role: Multiple PI
Duration: 8/1/2013 - 7/31/2018
Title: Microvesicles in CLL: Predictors of Disease Progression and Therapeutic Outcome
Funding Source: Mayo Clinic (CLL Global Research Foundation)
Role: Co-Principal Investigator
Principal Investigator: Ghosh
Duration: 4/1/2013 - 3/31/2015
Title: Characterization and Targeted Therapy of T-All deficient for PTEN and INK4A/ARF
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: You
Duration: 9/1/2012 - 8/31/2016
Title: Odyssey Fellowship-Hui Ling
Funding Source: MDACC Odyssey Fellowship
Role: Mentor
Duration: 9/1/2012 - 8/31/2015
Title: Rosalie B. Hite Fellowship Award-Maitri Shah
Funding Source: Rosalie B. Hite Fellowship Committee
Role: Mentor
Duration: 9/1/2012 - 8/31/2014
Title: Non-coding RNAs as Predictive Biomarkers of Benefit from Epidermal Growth Factor Receptor-targeted Therapies in Head and Neck Squamous Cell Carcinomas
Funding Source: Conquer Cancer Foundation Career Development Award
Role: Mentor
Principal Investigator: William
Duration: 7/1/2012 - 6/30/2015
Title: Phase II study of ofatumumab as front-line treatment in elderly, unfit patients with CLL
Funding Source: NCCN
Role: Principal Investigator
Duration: 10/10/2011 - 10/31/2015
Title: Non-codingRNA network in leukemias: functional and clinical significance
Funding Source: Leukemia and Lymphoma Society
Role: Principal Investigator
Duration: 7/1/2011 - 6/30/2016

Last updated: 8/31/2015