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George A Calin, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director,The RNA Interference and non-codingRNA Center, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Dr. Calin's main research interests are: 1) the involvementof non-coding RNAs in human diseases in general and of microRNAs in humancancers in particular, 2) the study of familial predisposition to humancancers, 3) the identification of ncRNA biomarkers in body fluids, and 4) thedevelopment of new RNA-basedtherapeutic options for cancer patients.

Please visit the Calin Lab.

Education & Training

Degree-Granting Education

2000 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, PHD, Faculty of Medicine
1992 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, MD, Faculty of Medicine

Experience/Service

Academic Appointments

Associate Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2007-8/2013
Assistant Professor, Ohio State University, Columbus, OH, 8/2006-6/2007
Research Assistant Professor, Ohio State University, Columbus, OH, 2005-2006
Assistant Professor, Gastroenterology, Carol Davila University, Bucharest, Romania, 1996-2002

Honors and Awards

2014-present Highly Cited Researchers, Thomson Reuters
2013 2013 Celegene Awards for Clinical Research in Hematology, Celegene
2013 2013 Julie and Ben Rogers Award for Excellence in the Area of Research
2012 Potu N. Rao Award for Excellence in Basic Science, Division of Cancer Medicine Faculty Excellence Awards, The University of Texas MD Anderson Cancer Center
2011-2016 The Alan M. Gerwitz Leukemia & Lymphoma Society Scholar, Leukemia & Lymphoma Society Society
2007-present Fellow of The University of Texas MD Anderson Research Trust, The University of Texas MD Anderson Cancer Center
2007-present The University of Texas System Regents' Research Scholar Program Award Recipient, The University of Texas MD Anderson Cancer Center
2004-2006 Kimmel Foundation Scholar, Kimmel Foundation
1997-1998 The Yamagiwa-Yoshida memorial International Cancer Study Grant, The International Union Against Cancer (Geneva), University of Ferrara, Italy
1988 Award at the National Competition on Human Physiology, Romania
1987 Award at the National Competition on Human Anatomy, Romania
1985 Award at the National Competition on Human Anatomy, Romania

Selected Publications

Peer-Reviewed Original Research Articles

1. Ferrajoli A, Ivan C, Ciccone M, Shimizu M, Kita Y, Ohtsuka M, D'Abundo L, Qiang J, Lerner S, Nouraee N, Rabe KG, Rassenti LZ, Van Roosbroeck K, Manning JT, Yuan Y, Zhang X, Shanafelt TD, Wierda WG, Sabbioni S, Tarrand JJ, Estrov Z, Radovich M, Liang H, Negrini M, Kipps TJ, Kay NE, Keating M, Calin GA. Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. EBioMedicine 2(6):572-82, 6/2015. e-Pub 4/29/2015. PMCID: PMC4535165.
2. Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. Cancer Cell 26(5):707-21, 11/10/2014. e-Pub 10/23/2014. PMCID: PMC4254633.
3. Nishimura M, Jung EJ, Shah MY, Lu C, Spizzo R, Shimizu M, Han HD, Ivan C, Rossi S, Zhang X, Nicoloso MS, Wu SY, Almeida MI, Bottsford-Miller J, Pecot CV, Zand B, Matsuo K, Shahzad MM, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Calin GA. Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discov 3(11):1302-15, 11/2013. e-Pub 9/3/2013. PMCID: PMC3855315.
4. Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B-chronic lymphocytic leukemia. Blood 122(11):1891-9, 9/12/2013. e-Pub 7/2/2013. PMCID: PMC3779381.
5. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 23(9):1446-61, 9/2013. e-Pub 6/24/2013. PMCID: PMC3759721.
6. Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, Gafà R, Xiao L, Zhang X, Vannini I, Fanini F, Fabbri M, Lanza G, Reis RM, Zweidler-McKay PA, Calin GA. Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells. Gastroenterology 142(4):886-896.e9, 4/2012. e-Pub 1/10/2012. PMCID: PMC3321100.
7. Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA 305(1):59-67, 1/5/2011. PMCID: PMC3690301.
8. Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu S, Schwind S, Santhanam R, Hickey CJ, Becker H, Chandler JC, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Liebhaber SA, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 140(5):652-65, 3/5/2010. PMCID: PMC2924756.
9. Spizzo R, Nicoloso M, Croce CM, Calin GA. Snap Shot: MicroRNAs in Cancer. Cell 137(3):586-586.e1, 5/2009. PMID: 19410551.
10. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12(3):215-29, 9/2007. PMID: 17785203.
11. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353(17):1793-801, 10/27/2005. PMID: 16251535.
12. Calin GA, Trapasso F, Shimizu M, Dumitru CD, Yendamuri S, Godwin AK, Ferracin M, Bernardi G, Chatterjee D, Baldassarre G, Rattan S, Alder H, Mabuchi H, Shiraishi T, Hansen LL, Overgaard J, Herlea V, Mauro FR, Dighiero G, Movsas B, Rassenti L, Kipps T, Baffa R, Fusco A, Mori M, Russo G, Liu CG, Neuberg D, Bullrich F, Negrini M, Croce CM. Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med 352(16):1667-76, 4/21/2005. PMID: 15843669.
13. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99(24):15524-9, 11/26/2002. e-Pub 11/14/2002. PMCID: PMC137750.

Last updated: 9/15/2015