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Honami Naora, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor (with tenure), Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

  • Cell differentiation and patterning
  • Cell transformation
  • Tumor progression and tumor microenvironment
  • Cancers of female reproductive organs

 

The research mission of my laboratory is to understand how aberrations of processes that normally control embryonic development contribute to tumorigenesis and tumor behavior. Cancer is increasingly thought to be an aberrant form of organogenesis or development "gone wrong". My laboratory primarily focuses on the role of homeobox genes in cancer. These genes encode transcription factors that normally control developmental patterning, but many are aberrantly expressed in tumors. We are particularly interested in cancers of the female reproductive organs, because these tissues exhibit dynamic developmental plasticity and represent ideal organ systems to study how tumorigenesis is intimately related to embryonic development. By investigating the molecular underpinnings of this relationship, our goal is to identify focal points for therapeutic intervention and more effective markers of early-stage disease.

 

Our key research questions include:

i) how do homeobox genes control evolution of different types of tumors from the same cell-of-origin?

ii) what sets of homeobox genes regulate tumor progression, and what are their mechanisms?

iii) how do homeobox genes cross-talk with other signaling pathways in tumors?

 

The studies in my laboratory are multi-disciplinary and integrate cancer biology with developmental biology. The projects include both molecular studies of gene regulation, and studies of tumor growth, histopathology, and interactions with the microenvironment using in vitro  and animal models.

 

 

Office Address

The University of Texas MD Anderson Cancer Center
7435 Fannin St.
Unit Number: 108
Houston, TX 77054
Room Number: 2SCR3.2028
Email: hnaora@mdanderson.org

Education & Training

Degree-Granting Education

1994 The Australian National University, Canberra, Australia, Ph.D., Field of study: Molecular Biology
1990 The Australian National University, Canberra, Australia, Bachelor Degree of Science with First-Class Honors, (B.S., Hons.), Field of study: Biochemistry

Postgraduate Training

1999-2000 Research Fellowship, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
1997-1998 Research Fellowship, Unité d'Oncologie Virale, Institut Pasteur, Paris, France
1994-1997 Research Fellowship, Research School of Biological Sciences, The Australian National University, Canberra, Australia

Experience/Service

Academic Appointments

Associate Professor (with tenure), Department of Systems Biology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2007-2013
Assistant Professor (tenure-track), Department of Systems Biology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2004-2007
Faculty member, Graduate School of Biomedical Sciences, University of Texas Health Sciences Center at Houston, Houston, TX, 2002-present
Assistant Professor (tenure-track), Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2002-2003
Research Associate (NTRA), Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 2000-2002

Consultantships

Advisory Board Member, HERA Foundation, Carbondale, Colorado, 2002-2009

Institutional Committee Activities

Departmental Representative (Mol & Cell Oncol), Faculty Senate, 2013-present
Committee Member, Executive Committee of the Faculty Senate, 2013-present
Committee Member, Institutional Biosafety Committee, 2013-present
Committee Member, Division of Cancer Medicine Research Awards Committee, 2011-2013
Departmental Representative (Systems Biology), Faculty Senate, 2010-2013
Chair, Graduate Program in Cancer Biology International Students Admissions Subcommittee, 2009-2011
Committee Member, Institutional Research Grants Review Committee (Basic Sciences), 2007-2010
Committee Member, Institutional Biosafety Committee, 2006-2011

Honors and Awards

2003 Eagle Award for Scientific Achievement, Cancer Fighters of Houston
2000-2002 Research Fellowship, Cancer Research and Prevention Foundation of America
1997-1998 Sidaction Fellowship, Fondation pour la Recherche Medicale, France
1990-1993 Australian Postgraduate Research Award, The Commonwealth Government of Australia
1989 Janet Elspeth Crawford Prize, The Australian National University

Selected Publications

Peer-Reviewed Original Research Articles

1. Ko SY, Ladanyi A, Lengyel E, Naora H. Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype. Am J Pathol. In Press.
2. Trinh BQ, Ko SY, Barengo N, Lin SY, Naora H. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs. Cancer Res 73:1000-10, 1/2013.
3. Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, Naora H. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest 122:3603-3617, 10/2012.
4. Trinh BQ, Barengo N, Naora H. Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β. Oncogene 30:2718-29, 6/2011.
5. Zheng J, Chang B, Yang G, Rosen DG, Mills GB, Naora H, Auersperg N, Malpica A, Liu J. Induction of high grade serous carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. Cell Cycle 9:140-45, 2010.
6. Ko SY, Lengyel E, Naora H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol Cell Endocrinol 317:112-9, 2010.
7. Ko SY, Guo H, Barengo N, Naora H. Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E. Clin Cancer Res 15:4336-4347, 2009. PMID: 19458052.
8. Hara F, Samuel S, Liu J, Rosen D, Langley RR, Naora H. A homeobox gene related to Drosophila Distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2. Am J Pathol 170:1595-1606, 2007.
9. Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: Role in epithelial-mesenchymal transition. Cancer Res 66:889-897, 2006. PMID: 16424022.
10. Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 11:531-537, 2005. PMID: 15821746.
11. Yoshida H, Liu J, Samuel S, Cheng W, Rosen D, Naora H. Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells. Mol Cell Endocrinol 245:77-85, 2005. PMID: 16298470.
12. Silver DL, Naora H, Liu J, Cheng W, Montell DJ. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res 64:3550-8, 5/2004. PMID: 15150111.
13. Yoshida H, Cheng W, Hung J, Montell D, Geisbrecht E, Rosen D, Liu J, Naora H. Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer. Proc Natl Acad Sci USA 101:8144-8149, 2004. PMID: 15146066.
14. Naora H, Yang Y, Montz FJ, Seidman JD, Kurman RJ, Roden RBS. A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells. Proc Natl Acad Sci USA 98:4060-4065, 2001.
15. Naora H, Montz FJ, Chai C-Y, Roden RBS. Aberrant expression of homeobox gene HOXA7 is associated with müllerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response. Proc Natl Acad Sci USA 98:15209-15214, 2001.
16. Usui, A, Ko SY, Barengo N, Naora H. P-cadherin promotes ovarian cancer dissemination by inhibiting anoikis and stimulating tumor-mesothelial cell interactions. Mol Cancer Res. Submitted.
17. Ko SY, Naora H. The homeoprotein HOXA9 promotes intraperitoneal dissemination of ovarian cancer by inducing P-cadherin expression. Submitted.

Invited Articles

1. Naora H, Montell DJ. Ovarian cancer metastasis: Integrating insights from disparate model organisms. Nat. Rev. Cancer 5:355-366, 2005. PMID: 15864277.
2. Naora H. Developmental patterning in the wrong context: The paradox of epithelial ovarian cancers. Cell Cycle 4:86-88, 2005. PMID: 16082202.
3. Samuel S, Naora H. Homeobox gene expression in cancer: Insights from developmental regulation and deregulation. Eur J Cancer 41:2428-2437, 2005. PMID: 16199152.
4. Naora H. The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms. Expert Rev Mol Med 9:1-12, 2007. PMID: 17477890.
5. Naora H. A peptide-based approach to inhibit the translational machinery in tumors. Chemistry Today 28:26-28, 2010.
6. Haria H, Naora H. Homeobox gene deregulation: Impact on the hallmarks of cancer. Cancer Hallmarks. In Press.
7. Naora H. Heterotypic cellular interactions in the ovarian tumor microenvironment: Biological significance and therapeutic implications. Front Oncol. Submitted.
8. Ko SY, Naora H. Targeting the ovarian tumor stroma. World J Clin Cases. Submitted.

Book Chapters

1. Trinh BQ, Naora H. Homeobox genes and their functional significance in ovarian tumorigenesis. In: Ovarian Cancer: Basic Science Perspective. Ed(s) Farghaly, SA. In-Tech Publishing, 2012.
2. Hennessy BT, Carey M, Naora H, Mills GB. Ovarian Cancer: Molecular, Cellular and Clinical Biology. In: Ovarian Cancer: State of the Art. Ed(s) Markham, M. and Bast, RC. Remedica Medical Education & Publishing, 2008.

Grant & Contract Support

Title: Homeobox gene-mediated regulation of sensitivity of leukemic cells to tyrosine kinase inhibitors, Leukemia SPORE Development Award
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 5/1/2013 - 4/30/2014

Last updated: 12/27/2013