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Huamin Wang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Pathology/Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Professor, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1999 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Molecular Biology and Biochemistry
1987 Tongji Medical University, Wuhan, China, MD, Medicine, Certified by Educational Commission for Foreign Medical Graduates in May 1998

Board Certifications

7/2003 Diplomat of the American Board of Pathology in Combined Anatomical Pathology and Clinical Pathology


Academic Appointments

Associate Professor, (Term Tenure) Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2009-8/2015

Selected Publications

Peer-Reviewed Original Research Articles

1. Fogelman D, Sugar EA, Oliver G, Shah N, Klein A, Alewine C, Wang H, Javle M, Shroff R, Wolff RA, Abbruzzese JL, Laheru D, Diaz LA. Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma. Cancer Chemother Pharmacol 76(3):489-98, 9/2015. e-Pub 7/1/2015. PMID: 26126726.
2. Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, Maitra A, Wang H, Tian W, Taguchi A, Hanash SM. Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. J Natl Cancer Inst 107(8), 8/2015. e-Pub 5/29/2015. PMID: 26025324.
3. Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, Wang H, Wang H, Qin H. Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α. Gut. e-Pub 5/20/2015. PMID: 25994219.
4. Wang H, Maitra A, Wang H. Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer. Clin Cancer Res. e-Pub 5/20/2015. PMID: 25995340.
5. Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB, Estrella J, Rashid A, Wang H. The number and ratio of positive lymph nodes affect pancreatic cancer patient survival after neoadjuvant therapy and pancreaticoduodenectomy. Histopathology. e-Pub 5/6/2015. PMID: 25945396.
6. Roland CL, Yang AD, Katz MH, Chatterjee D, Wang H, Lin H, Vauthey JN, Pisters PW, Varadhachary GR, Wolff RA, Crane CH, Lee JE, Fleming JB. Neoadjuvant Therapy is Associated with a Reduced Lymph Node Ratio in Patients with Potentially Resectable Pancreatic Cancer. Ann Surg Oncol 22(4):1168-75, 4/2015. e-Pub 10/29/2014. PMID: 25352267.
7. Arumugam T, Deng D, Bover L, Wang H, Logsdon CD, Ramachandran V. New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice. Mol Cancer Ther 14(4):941-51, 4/2015. e-Pub 2/2/2015. PMID: 25646014.
8. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res 75(6):1091-101, 3/15/2015. e-Pub 3/3/2015. PMID: 25736685.
9. Kang Y, Zhang R, Suzuki R, Li SQ, Roife D, Truty MJ, Chatterjee D, Thomas RM, Cardwell J, Wang Y, Wang H, Katz MH, Fleming JB. Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype. Lab Invest 95(2):207-22, 2/2015. e-Pub 12/8/2014. PMID: 25485535.
10. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velasquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. Clin Cancer Res, 1/2015.
11. Luo Z, Li Y, Wang H, Fleming J, Li M, Kang Y, Zhang R, Li D. Hepatocyte Nuclear Factor 1A (HNF1A) as a Possible Tumor Suppressor in Pancreatic Cancer. PLoS One 10(3):e0121082, 2015. e-Pub 3/20/2015. PMCID: PMC4368635.
12. Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun 6:7351, 2015. e-Pub 6/17/2015. PMID: 26081979.
13. Li X, Truty MA, Kang Y, Chopin-Laly X, Zhang R, Roife D, Chatterjee D, Lin E, Thomas RM, Wang H, Katz MH, Fleming JB. Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery. Clin Cancer Res 20(24):6529-40, 12/15/2014. e-Pub 10/21/2014. PMCID: PMC4268437.
14. Gonzalez-Villasana V, Rodriguez-Aguayo C, Arumugam T, Cruz-Monserrate Z, Fuentes-Mattei E, Deng D, Hwang RF, Wang H, Ivan C, Garza RJ, Cohen E, Gao H, Armaiz-Pena GN, Del C Monroig-Bosque P, Philip B, Rashed MH, Aslan B, Erdogan MA, Gutierrez-Puente Y, Ozpolat B, Reuben JM, Sood AK, Logsdon C, Lopez-Berestein G. Bisphosphonates Inhibit Stellate Cell Activity and Enhance Antitumor Effects of Nanoparticle Albumin-Bound Paclitaxel in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 13(11):2583-94, 11/2014. e-Pub 9/5/2014. PMCID: PMC4221441.
15. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32, 10/30/2014. e-Pub 8/10/2014. PMCID: PMC4376130.
16. Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR. Expression of Estrogen-Induced Genes and Estrogen Receptor β in Pancreatic Neuroendocrine Tumors: Implications for Targeted Therapy. Pancreas 43(7):996-1002, 10/2014. e-Pub 7/2014. PMID: 25058880.
17. Wang H, Estrella JS, Chatterjee D, Katz MH, Rashid A, Wang H, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB. Hepatobiliary/Pancreas Pathology: SY11-3 PANCREATIC DUCTAL ADENOCARCINOMA: NEOADJUVANT THERAPIES AND PATHOLOGY. Pathology 46 Suppl 2:S25, 10/2014. PMID: 25188109.
18. Roland CL, Arumugam T, Deng D, Liu SH, Philip B, Gomez S, Burns WR, Ramachandran V, Wang H, Cruz-Monserrate Z, Logsdon CD. Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Res 74(18):5301-10, 9/15/2014. e-Pub 6/13/2014. PMCID: PMC4167222.
19. Estrella JS, Broaddus RR, Mathews A, Milton DR, Yao JC, Wang H, Rashid A. Progesterone Receptor and PTEN Expression Predict Survival in Patients with Low and Intermediate Grade Pancreatic Neuroendocrine Tumors. Arch Pathol Lab Med 138(8):1027-36, 8/2014. PMID: 25076292.
20. Foo WC, Wang H, Prieto VG, Fleming JB, Abraham SC. Squamoid cystosis of pancreatic ducts: a variant of a newly-described cystic lesion, with evidence for an obstructive etiology. Rare Tumors 6(3):5286, 7/2014. e-Pub 9/2014. PMCID: PMC4178271.
21. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 158(1):185-97, 7/2014. e-Pub 6/2014. PMCID: PMC4109295.
22. Guo R, Overman M, Chatterjee D, Rashid A, Shroff S, Wang H, Katz MH, Fleming JB, Varadhachary GR, Abbruzzese JL, Wang H. Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma. Hum Pathol 45(5):1015-23, 5/2014. e-Pub 1/17/2014. PMID: 24746206.
23. Tzeng CW, Balachandran A, Ahmad M, Lee JE, Krishnan S, Wang H, Crane CH, Wolff RA, Varadhachary GR, Pisters PW, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Serum CA 19-9 Represents a Marker of Response to Neoadjuvant Therapy in Patients with Borderline Resectable Pancreatic Cancer. HPB (Oxford) 16(5):430-8, 5/2014. e-Pub 8/2013. PMCID: PMC4008161.
24. Koay EJ, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Bhosale PR, Tamm EP, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Varadhachary GR, Ferrari M, Fleming JB. Transport properties of pancreatic cancer describe gemcitabine delivery and response. J Clin Invest 124(4):1525-36, 4/2014. e-Pub 3/2014. PMCID: PMC3973100.
25. Gong J, Xie J, Bedolla R, Rivas P, Chakravarthy D, Freeman JW, Reddick R, Kopetz S, Peterson A, Wang H, Fischer SM, Kumar AP. Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer. Clin Cancer Res 20(5):1259-73, 3/1/2014. e-Pub 2/11/2014. PMCID: PMC3969421.
26. Christians KK, Tsai S, Mahmoud A, Ritch P, Thomas JP, Wiebe L, Kelly T, Erickson B, Wang H, Evans DB, George B. Neoadjuvant FOLFIRINOX for borderline resectable pancreas cancer: a new treatment paradigm? Oncologist 19(3):266-74, 3/2014. e-Pub 2/2014. PMCID: PMC3958454.
27. Shroff S, Rashid A, Wang H, Katz MH, Abbruzzese JL, Fleming JB, Wang H. SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms. Hum Pathol 45(3):456-63, 3/2014. e-Pub 10/19/2013. PMCID: PMC3945019.
28. Tran Cao HS, Balachandran A, Wang H, Nogueras-González GM, Bailey CE, Lee JE, Pisters PW, Evans DB, Varadhachary G, Crane CH, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Radiographic Tumor-Vein Interface as a Predictor of Intraoperative, Pathologic, and Oncologic Outcomes in Resectable and Borderline Resectable Pancreatic Cancer. J Gastrointest Surg 18(2):269-78; discussion 278, 2/2014. e-Pub 10/2013. PMCID: PMC4016045.
29. Estrella JS, Li L, Rashid A, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Solid Pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. Am J Surg Pathol 38(2):147-57, 2/2014. PMID: 24418850.
30. *Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan TH, Wang H. The CUL7/F-box and WD Repeat Domain Containing 8 (CUL7/Fbxw8) Ubiquitin Ligase Promotes Degradation of Hematopoietic Progenitor Kinase 1. J Biol Chem 289(7):4009-17, 2/2014. e-Pub 12/2013. PMCID: PMC3924268.
31. Tzeng CW, Tran Cao HS, Lee JE, Pisters PW, Varadhachary GR, Wolff RA, Abbruzzese JL, Crane CH, Evans DB, Wang H, Abbott DE, Vauthey JN, Aloia TA, Fleming JB, Katz MH. Treatment Sequencing for Resectable Pancreatic Cancer: Influence of Early Metastases and Surgical Complications on Multimodality Therapy Completion and Survival. J Gastrointest Surg 18(1):16-24; discussion 24-5, 1/2014. e-Pub 11/2013. PMID: 24241967.
32. Chang Z, Ju H, Ling J, Zhuang Z, Li Z, Wang H, Fleming JB, Freeman JW, Yu D, Huang P, Chiao PJ. Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis. PLoS One 9(7):e101452, 2014. e-Pub 7/16/2014. PMCID: PMC4100754.
33. Ligr M, Wu X, Daniels G, Zhang D, Wang H, Hajdu C, Wang J, Pan R, Pei Z, Zhang L, Melis M, Pincus MR, Saunders JK, Lee P, Xu R. Imbalanced expression of Tif1γ inhibits pancreatic ductal epithelial cell growth. Am J Cancer Res 4(3):196-210, 2014. e-Pub 5/2014. PMCID: PMC4065401.
34. Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, Truty MJ, Chatterjee D, Wang H, Thomas RM, Katz MH, Chiao PJ, Fleming JB. SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium. PLoS One 9(9):e107948, 2014. e-Pub 9/29/2014. PMCID: PMC4180072.
35. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, Colon Cancer Family Registry (CCFR), Stenzel SL, Schumacher FR, Peters U, Gruber SB, Colorectal Transdisciplinary Study (CORECT), Tsugane S, Stram DO, Le Marchand L. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 5:4613, 2014. e-Pub 8/8/2014. PMCID: PMC4180879.
36. Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, Ji B, Huang H, Wang H, Fleming JB, Logsdon CD, Cruz-Monserrate Z. A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology 145(6):1449-58, 12/2013. e-Pub 8/2013. PMCID: PMC3873752.
37. *Zenali M, Overman MJ, Rashid A, Broaddus RB, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Clinicopathologic Features and Prognosis of Duodenal Adenocarcinoma and Comparison with Ampullary and Pancreatic Ductal Adenocarcinoma. Hum Pathol 44(12):2792-8, 12/2013. e-Pub 10/2013. PMID: 24139211.
38. *Chatterjee D, Katz MH, Rashid A, Estrella JS, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB, Wang H. Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology 63(6):841-51, 12/2013. e-Pub 9/2013. PMCID: PMC3836824.
39. *Shroff S, Overman MJ, Rashid A, Shroff RT, Wang H, Chatterjee D, Katz MH, Lee JE, Wolff RA, Abbruzzese JL, Fleming JB, Wang H. The Expression of PTEN is Associated With Improved Prognosis in Patients With Ampullary Adenocarcinoma After Pancreaticoduodenectomy. Arch Pathol Lab Med 137(11):1619-26, 11/2013. PMID: 24168499.
40. Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis. Cell Rep S2211-1247(13):00549-4, 10/2013. PMID: 24209743.
41. Jiang ZQ, Varadhachary G, Wang X, Kopetz S, Lee JE, Wang H, Shroff R, Katz M, Wolff RA, Fleming J, Overman MJ. A retrospective study of ampullary adenocarcinomas: overall survival and responsiveness to fluoropyrimidine-based chemotherapy. Ann Oncol 24(9):2349-53, 9/2013. e-Pub 5/2013. PMCID: PMC3841462.
42. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med 5(9):1322-34, 2013. PMCID: PMC3799489.
43. Huang H, Liu Y, Daniluk J, Gaiser S, Chu J, Wang H, Li ZS, Logsdon CD, Ji B. Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology 144(1):202-10, 2013. PMCID: PMC3769090.
44. Bilen MA, Kim J, Wang H, Tu SM. Cixutumumab-Associated Pancolitis in a Patient With Prostate Cancer. Clin Genitourin Cancer 11(2):207-10, 2013. PMCID: PMC3579009.
45. Bhosale P, Balachandran A, Wang H, Wei W, Hwang RF, Fleming JB, Varadhachary G, Charnsangavej C, Tamm E. CT imaging features of acinar cell carcinoma and its hepatic metastases. Abdom Imaging 28(6):1383-90, 2013. PMID: 23232580.
46. Chang Z, Li Z, Wang X, Kang Y, Yuan Y, Niu J, Wang H, Chatterjee D, Fleming JB, Li M, Abbruzzese JL, Chiao PJ. Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells. Clin Cancer Res 144(1):202-10, 2013. PMCID: PMC3576034.
47. Overman MJ, Zhang J, Kopetz S, Davies M, Jiang Z-Q, Stemke-Hale K, Rümmele P, Pilarsky C, Grützmann R, Hamilton S, Hwang R, Abbruzzese JL, Varadhachary G, Broom B, Wang H. Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome. PLoS One 8(6), 2013. PMCID: PMC3679143.
48. Canto MI, Harinck F, Hruban RH, Offerhaus GJ, Poley JW, Kamel I, Nio Y, Schulick RS, Bassi C, Kluijt I, Levy MJ, Chak A, Fockens P, Goggins M, Bruno M, on behalf of the International Cancer of the Pancreas Screening (CAPS) Consortium. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut 62(3):339-47, 2013. PMCID: PMC3585492.
49. *Liu X, Lee JH, Charnsangavej C, Geng M, Wang H. Long Survival after Resection of Small Cell Carcinoma of the Pancreas with Synchronous Adenocarcinoma of the Ampulla of Vater. American Journal of Clinical Cancer Research Vol 1(Article ID 20130200152), 2013.
50. *Foo WC, Rashid A, Wang H, Katz MH, Lee JE, Pisters PW, Wolff RA, Abbruzzese JL, Fleming JB, Wang H. Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. Hum Pathol 44(6):1024-30, 2013. PMCID: PMC3832989.
51. Liu X, Xie H, Wang H, McMahon J, Patil DT, Yerian LM. Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation. J Med Cases 4(8):544-549, 2013.
52. Abd-Elgaliel WR, Cruz-Monserrate Z, Wang H, Logsdon CD, Tung CH. Pancreatic cancer-associated Cathepsin E as a drug activator. J Control Release 167(3):221-7, 2013. PMCID: PMC3638719.
53. Lewis GH, Wang H, Bellizzi AM, Klein AP, Askin FB, Schwartz LE, Schulick RD, Wolfgang CL, Cameron JL, O'Reilly EM, Yu KH, Hruban RH. Prognosis of Minimally Invasive Carcinoma Arising in Mucinous Cystic Neoplasms of the Pancreas. Am J Surg Pathol 37(4):601-605, 2013. PMCID: PMC3596434.
54. *Li L, Othman M, Rashid A, Wang H, Li Z, Katz MH, Lee JE, Pisters PWT, Abbruzzese JL, Fleming JB, Wang H. Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology 62(3):465-71, 2013. PMCID: PMC3553313.
55. *Zhao Q, Han X-Y, Balachandran A, Wang H. Toxic megacolon and fungal diverticulitis and liver abscess due to Mucor indicus infection in a patient with chronic myelogenous leukemia. American Journal of Clinical Cancer Research Vo1. 1, Article ID 20130200151, 2013.
56. Kim MP, Truty MJ, Choi W, Kang Y, Chopin-Lally X, Gallick GE, Wang H, McConkey DJ, Hwang R, Logsdon C, Abbruzzesse J, Fleming JB. Molecular Profiling of Direct Xenograft Tumors Established from Human Pancreatic Adenocarcinoma After Neoadjuvant Therapy. Ann Surg Oncol Suppl 3:S395-403, 7/2012. e-Pub 6/2011. PMID: 21701930.
57. Daniluk J, Liu Y, Deng D, Chu J, Huang H, Gaiser S, Cruz-Monserrate Z, Wang H, Ji B, Logsdon CD. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 122(4):1519-28, 2012. PMCID: PMC3314459.
58. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21(2):196-211, 2012. PMCID: PMC3760020.
59. Cruz-Monserrate Z, Abd-Elgaliel WR, Grote T, Deng D, Ji B, Arumugam T, Wang H, Tung CH, Logsdon CD. Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models. Gut 61(9):1315-22, 2012. PMCID: PMC3966534.
60. Katz MH, Wang H, Balachandran A, Bhosale P, Crane CH, Wang X, Pisters PW, Lee JE, Vauthey JN, Abdalla EK, Wolff R, Abbruzzese J, Varadhachary G, Chopin-Laly X, Charnsangavej C, Fleming JB. Effect of Neoadjuvant Chemoradiation and Surgical Technique on Recurrence of Localized Pancreatic Cancer. J Gastrointest Surg 16(1):68-78, 2012. PMID: 22065318.
61. *Chatterjee D, Katz MH, Rashid A, Varadhachary GR, Wolff RA, Wang H, Lee JE, Pisters PW, Vauthey JN, Crane C, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome. Cancer 118(12):3182-90, 2012. PMCID: PMC3269538.
62. *Wang J, Estrella JS, Peng L, Rashid A, Varadhachary GR, Wang H, Lee JE, Pisters PW, Vauthey JN, Katz MH, Gomez HF, Evans DB, Abbruzzese JL, Fleming JB, Wang H. Histologic Tumor Involvement of Superior Mesenteric Vein/Portal Vein Predicts Poor Prognosis in Patients with Stage II Pancreatic Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Cancer 118(15):3801-11, 2012. PMCID: PMC3310937.
63. Chang DZ, Ma Y, Ji B, Liu Y, Hwu P, Abbruzzese JL, Logsdon C, Wang H. Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. J Hematol Oncol 5:15, 2012. PMCID: PMC3350393.
64. Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21(1):105-20, 2012. PMCID: PMC3360958.
65. Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol 10(5):e1001326, 2012. PMCID: PMC3348157.
66. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PLoS One 7(8):e42699, 2012. PMCID: PMC3416861.
67. *Weng S, Wang H, Chen W, Katz MH, Chatterjee D, Lee JE, Pisters PW, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Overexpression of Protein Phosphatase 4 Correlates with Poor Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev 21(8):1336-43, 2012. PMCID: PMC3417753.
68. *Zhao Q, Rashid A, Gong Y, Katz MH, Lee JE, Wolf R, Balachandran A, Varadhachary GR, Pisters PW, Wang H, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosis. Ann Diagn Pathol 16(1):29-37, 2012. PMCID: PMC3832988.
69. *Chatterjee D, Katz MH, Rashid A, Wang H, Iuga AC, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Crane CH, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Perineural and Intra-neural Invasion in Posttherapy Pancreaticoduodenectomy Specimens Predicts Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma. Am J Surg Pathol 36(3):409-17, 2012. PMCID: PMC3288807.
70. *Estrella JS, Rashid A, Fleming JB, Katz MH, Lee JE, Wolf RA, Varadhachary GR, Pisters PW, Abdalla EK, Vauthey JN, Wang H, Gomez HF, Evans DB, Abbruzzese JL, Wang H. Posttherapy Pathologic Stage and Survival in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Cancer 118(1):268-77, 2012. PMID: 21735446.
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167. Tao Y, Wang H, Liu J, Tan Y, and Li W. Utilization of geothermal water and its effect on human health. Journal of Hygiene Research 21(1):21-3, 1992.
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Invited Articles

1. Dhingra S, Wang H. Non-neoplastic Signet Ring Cell Change in Gastrointestinal and Biliary Tract: A Pitfall for Overdiagnosis. Ann Diagn Pathol 15(6):490-6, 12/2011. PMID: 22082777.
2. Katz MH, Mortenson MM, Wang H, Hwang R, Tamm EP, Staerkel G, Lee JH, Evans DB, Fleming JB. Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approach. J Am Coll Surg 207(1):106-120, 7/2008. e-Pub 4/24/2008. PMID: 18589369.
3. Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB. Current diagnosis and management of unusual pancreatic tumors. American Journal of Surgery 196(1):100-113, 2008.
4. Akkiprik M, Feng Y, Wang H, Chen K, Hu L, Sahin A, Krishnamurthy S, Ozer A, Hao X, Zhang W. Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer. Breast Cancer Res 10(4):212, 2008. PMCID: PMC2575530.
5. Varadhachary GR, Tamm EP, Abbruzzese JL, Crane CH, Wang H, Lee JE, Pisters PWT, Evans DB, and Wolff RA. Borderline resectable pancreatic Cancer: definitions, management, and the role of preoperative therapy. Annals of Surgical Oncology 13(8):1035-46, 2006.
6. Wang H, Medeiros LJ, Jones D. Subcutaneous panniculitis-like T-cell lymphoma. Clin Lymphoma 3(3):181-3, 12/2002. PMID: 12521397.
7. Wang H, Wang H, Zhang W, Fuller GN. Tissue microarrays: applications in neuropathology research, diagnosis, and education. Brain Pathol 12(1):95-107, 2002. PMID: 11770905.
8. Strobel HW, Geng J, Kawashima H, Wang H. Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue. Drug Metab Rev 29(4):1079-105, 1997. PMID: 9421686.
9. Strobel HW, Kawashima H, Geng J, Sequeira D, Bergh A, Hodgson AV, Wang H, Shen S. Expression of multiple forms of brain cytochrome P450. Toxicol Lett 82-83:639-43, 1995. PMID: 8597121.

Letters to the Editor

1. Overman M, Wang H, Varadhachary GR. Adjuvant chemotherapy for resected periampullary adenocarcinoma. Author Reply 1855-6. JAMA 308(18):1855; author reply 1855-6, 11/2012. PMID: 23149995.
2. Wang H, Zhao Q. Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with better prognosis. Author Reply. Ann Diagn Pathol 16(5):427, 10/2012. e-Pub 5/2012. PMID: 22561135.
3. Overman MJ, Wolff RA, Wang H. Reply to comment: Cetuximab in small bowel adenocarinoma (SBA): a new friend? British Journal of Cancer 103(8):1306, 10/2010. PMCID: PMCPMC2967067.

Grant & Contract Support

Title: Biomarkers for early detection of pancreatic cancer. Core fund to U01 (CA086402)
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Subrata Sen
Duration: 7/1/2015 - 6/30/2016
Title: The KillRas Flagship Project
Funding Source: The Pancreas Cancer Moon Shot Program, MDACC
Role: Co-Investigator
Principal Investigator: Maitra A., Fleming JB, & Wolff RA
Duration: 9/1/2014 - 8/31/2015
Title: Discovery of Risk Loci and Genomics of Pancreatic Cancer through Exome Sequencing
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Paul Scheet
Duration: 7/11/2014 - 5/31/2019
Title: Development of Tissue Microarrays for Pancreatic Cancer and Pancreatic Precursor Lesions
Funding Source: Khalifa Bin Zayed Al Nahyan Foundation Institute For Pancreatic Cancer Research, The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2013 - 6/30/2015
Title: Hematopoietic Progenitor Kinase 1: A Novel Negative Regulator of Ras Signaling in Pancreatic Cancer
Funding Source: G. S. Hogan Gastrointestinal Cancer Research Fund, The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2015
Title: A Novel Preoperative Platform in Pancreatic Cancer for Mechanistic Studies
Funding Source: Lustgarten Foundation for Pancreatic Cancer
Role: Co-Investigator
Principal Investigator: Gauri Varadhachary
Duration: 5/1/2011 - 4/30/2015
Title: Proteasome-medicated Degradation of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2011 - 3/31/2014
Title: Conditional ablation of stellate cells to determine their role in pancreatitis and pancreatic cancer
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Rosa Hwang
Duration: 12/1/2010 - 11/30/2012
Title: Stellate cell-specific targeting in pancreatic cancer
Funding Source: American Association for Cancer Research (AACR) - PanCAN, Innovative Grant
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 7/1/2010 - 6/30/2012
Title: Role of Dietary Zinc Transporter ZIP4 in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Min Li
Duration: 4/2010 - 1/2015
Title: Wnt signaling in pancreatic cancer associated-stroma
Funding Source: The Lustgarten Foundation
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 1/1/2010 - 12/31/2010
Title: Stromal Periostin in Pancreatitis and Pancreas Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 12/1/2009 - 11/30/2014
Title: Roles of MicroRNAs and Ultraconserved Genes in Pancreatic Cancers
Funding Source: American Association for Cancer Research (AACR)
Role: Co-Investigator
Principal Investigator: Calin, G
Duration: 7/1/2009 - 6/30/2011
Title: Functions of ubiquitin E3 ligase, Fbw8, in proteasome-mediated degradation of hematopoietic progenitor kinase 1 in pancreatic cancer
Funding Source: Institutional Research Grant (Basic Laboratory Research), The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2009 - 6/30/2010
Title: KLF4 Genetic and epigenetic changes in human pancreatic cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xie, Keping
Duration: 9/2008 - 7/2013
Title: Survivin and interferon as a cancer vaccine for pancreatic cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Chang, David Z.
Duration: 9/2008 - 8/2010
Title: Lockton Grant Matching Program for Pancreatic Cancer Research, M. D. Anderson Cancer Center
Funding Source: The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2008 - 12/31/2008
Title: Functional study of hematopoietic progenitor kinase-1 (HPK1) in pancreatic cancer
Funding Source: American Association for Cancer Research-PanCAN Career Development Award
Role: Principal Investigator
Duration: 7/1/2007 - 6/30/2010
Title: Clinicopathologic characteristics and molecular alterations of pancreatic ductal adenocarcinoma in patients of 45 years of age and younger
Funding Source: Fellow's Intramural Research Grant/The University of Texas M.D. Anderson Cancer Center
Role: Mentor for FY06-07 Fellow Research Project Award (Fellow: John Liang, MD, PhD)
Principal Investigator: John J. Liang
Duration: 7/1/2006 - 6/30/2007
Title: Genetics and Biology of Pancreatic Ductal Adenocarcinoma
Funding Source: NIH/NCI
Role: Core PI
Principal Investigator: Ronald DePinho
Duration: 4/15/2006 - 12/31/2015
Title: Pancreatic Cancer Tissue core. Specialized Program of Research Excellence (SPORE) in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: James L. Abbruzzese
Duration: 9/30/2003 - 8/31/2008
Title: Prognostic significance of insulin-like growth factor binding proteins in breast and ovarian cancers
Funding Source: Fellow's Intramural Research Grant/The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2003 - 6/30/2004

Last updated: 2/24/2016