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Huamin Wang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, (Term Tenure) Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Associate Professor, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1999 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Molecular Biology and Biochemistry
1987 Tongji Medical University, Wuhan, China, MD, Medicine, Certified by Educational Commission for Foreign Medical Graduates in May 1998

Board Certifications

7/2003 Diplomat of the American Board of Pathology in Combined Anatomical Pathology and Clinical Pathology

Selected Publications

Peer-Reviewed Original Research Articles

1. Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, Maitra A, Wang H, Tian W, Taguchi A, Hanash SM. Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. J Natl Cancer Inst 107(8), 8/2015. e-Pub 5/29/2015. PMID: 26025324.
2. Fogelman D, Sugar EA, Oliver G, Shah N, Klein A, Alewine C, Wang H, Javle M, Shroff R, Wolff RA, Abbruzzese JL, Laheru D, Diaz LA. Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma. Cancer Chemother Pharmacol. e-Pub 7/1/2015. PMID: 26126726.
3. Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, Wang H, Wang H, Qin H. Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α. Gut. e-Pub 5/20/2015. PMID: 25994219.
4. Wang H, Maitra A, Wang H. Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer. Clin Cancer Res. e-Pub 5/20/2015. PMID: 25995340.
5. Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB, Estrella J, Rashid A, Wang H. The number and ratio of positive lymph nodes affect pancreatic cancer patient survival after neoadjuvant therapy and pancreaticoduodenectomy. Histopathology. e-Pub 5/6/2015. PMID: 25945396.
6. Roland CL, Yang AD, Katz MH, Chatterjee D, Wang H, Lin H, Vauthey JN, Pisters PW, Varadhachary GR, Wolff RA, Crane CH, Lee JE, Fleming JB. Neoadjuvant Therapy is Associated with a Reduced Lymph Node Ratio in Patients with Potentially Resectable Pancreatic Cancer. Ann Surg Oncol 22(4):1168-75, 4/2015. e-Pub 10/29/2014. PMID: 25352267.
7. Arumugam T, Deng D, Bover L, Wang H, Logsdon CD, Ramachandran V. New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice. Mol Cancer Ther 14(4):941-51, 4/2015. e-Pub 2/2/2015. PMID: 25646014.
8. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res 75(6):1091-101, 3/15/2015. e-Pub 3/3/2015. PMID: 25736685.
9. Kang Y, Zhang R, Suzuki R, Li SQ, Roife D, Truty MJ, Chatterjee D, Thomas RM, Cardwell J, Wang Y, Wang H, Katz MH, Fleming JB. Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype. Lab Invest 95(2):207-22, 2/2015. e-Pub 12/8/2014. PMID: 25485535.
10. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velasquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. Clin Cancer Res, 1/2015.
11. Luo Z, Li Y, Wang H, Fleming J, Li M, Kang Y, Zhang R, Li D. Hepatocyte Nuclear Factor 1A (HNF1A) as a Possible Tumor Suppressor in Pancreatic Cancer. PLoS One 10(3):e0121082, 2015. e-Pub 3/20/2015. PMCID: PMC4368635.
12. Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun 6:7351, 2015. e-Pub 6/17/2015. PMID: 26081979.
13. Li X, Truty MA, Kang Y, Chopin-Laly X, Zhang R, Roife D, Chatterjee D, Lin E, Thomas RM, Wang H, Katz MH, Fleming JB. Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery. Clin Cancer Res 20(24):6529-40, 12/15/2014. e-Pub 10/21/2014. PMCID: PMC4268437.
14. Gonzalez-Villasana V, Rodriguez-Aguayo C, Arumugam T, Cruz-Monserrate Z, Fuentes-Mattei E, Deng D, Hwang RF, Wang H, Ivan C, Garza RJ, Cohen E, Gao H, Armaiz-Pena GN, Del C Monroig-Bosque P, Philip B, Rashed MH, Aslan B, Erdogan MA, Gutierrez-Puente Y, Ozpolat B, Reuben JM, Sood AK, Logsdon C, Lopez-Berestein G. Bisphosphonates Inhibit Stellate Cell Activity and Enhance Antitumor Effects of Nanoparticle Albumin-Bound Paclitaxel in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 13(11):2583-94, 11/2014. e-Pub 9/5/2014. PMCID: PMC4221441.
15. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32, 10/30/2014. e-Pub 8/10/2014. PMCID: PMC4376130.
16. Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR. Expression of Estrogen-Induced Genes and Estrogen Receptor β in Pancreatic Neuroendocrine Tumors: Implications for Targeted Therapy. Pancreas 43(7):996-1002, 10/2014. e-Pub 7/2014. PMID: 25058880.
17. Wang H, Estrella JS, Chatterjee D, Katz MH, Rashid A, Wang H, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB. Hepatobiliary/Pancreas Pathology: SY11-3 PANCREATIC DUCTAL ADENOCARCINOMA: NEOADJUVANT THERAPIES AND PATHOLOGY. Pathology 46 Suppl 2:S25, 10/2014. PMID: 25188109.
18. Roland CL, Arumugam T, Deng D, Liu SH, Philip B, Gomez S, Burns WR, Ramachandran V, Wang H, Cruz-Monserrate Z, Logsdon CD. Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Res 74(18):5301-10, 9/15/2014. e-Pub 6/13/2014. PMCID: PMC4167222.
19. Estrella JS, Broaddus RR, Mathews A, Milton DR, Yao JC, Wang H, Rashid A. Progesterone Receptor and PTEN Expression Predict Survival in Patients with Low and Intermediate Grade Pancreatic Neuroendocrine Tumors. Arch Pathol Lab Med 138(8):1027-36, 8/2014. PMID: 25076292.
20. Foo WC, Wang H, Prieto VG, Fleming JB, Abraham SC. Squamoid cystosis of pancreatic ducts: a variant of a newly-described cystic lesion, with evidence for an obstructive etiology. Rare Tumors 6(3):5286, 7/2014. e-Pub 9/2014. PMCID: PMC4178271.
21. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 158(1):185-97, 7/2014. e-Pub 6/2014. PMCID: PMC4109295.
22. Guo R, Overman M, Chatterjee D, Rashid A, Shroff S, Wang H, Katz MH, Fleming JB, Varadhachary GR, Abbruzzese JL, Wang H. Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma. Hum Pathol 45(5):1015-23, 5/2014. e-Pub 1/17/2014. PMID: 24746206.
23. Tzeng CW, Balachandran A, Ahmad M, Lee JE, Krishnan S, Wang H, Crane CH, Wolff RA, Varadhachary GR, Pisters PW, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Serum CA 19-9 Represents a Marker of Response to Neoadjuvant Therapy in Patients with Borderline Resectable Pancreatic Cancer. HPB (Oxford) 16(5):430-8, 5/2014. e-Pub 8/2013. PMCID: PMC4008161.
24. Koay EJ, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Bhosale PR, Tamm EP, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Varadhachary GR, Ferrari M, Fleming JB. Transport properties of pancreatic cancer describe gemcitabine delivery and response. J Clin Invest 124(4):1525-36, 4/2014. e-Pub 3/2014. PMCID: PMC3973100.
25. Gong J, Xie J, Bedolla R, Rivas P, Chakravarthy D, Freeman JW, Reddick R, Kopetz S, Peterson A, Wang H, Fischer SM, Kumar AP. Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer. Clin Cancer Res 20(5):1259-73, 3/1/2014. e-Pub 2/11/2014. PMCID: PMC3969421.
26. Christians KK, Tsai S, Mahmoud A, Ritch P, Thomas JP, Wiebe L, Kelly T, Erickson B, Wang H, Evans DB, George B. Neoadjuvant FOLFIRINOX for borderline resectable pancreas cancer: a new treatment paradigm? Oncologist 19(3):266-74, 3/2014. e-Pub 2/2014. PMCID: PMC3958454.
27. Shroff S, Rashid A, Wang H, Katz MH, Abbruzzese JL, Fleming JB, Wang H. SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms. Hum Pathol 45(3):456-63, 3/2014. e-Pub 10/19/2013. PMCID: PMC3945019.
28. Tran Cao HS, Balachandran A, Wang H, Nogueras-González GM, Bailey CE, Lee JE, Pisters PW, Evans DB, Varadhachary G, Crane CH, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Radiographic Tumor-Vein Interface as a Predictor of Intraoperative, Pathologic, and Oncologic Outcomes in Resectable and Borderline Resectable Pancreatic Cancer. J Gastrointest Surg 18(2):269-78; discussion 278, 2/2014. e-Pub 10/2013. PMCID: PMC4016045.
29. Estrella JS, Li L, Rashid A, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Solid Pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. Am J Surg Pathol 38(2):147-57, 2/2014. PMID: 24418850.
30. *Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan TH, Wang H. The CUL7/F-box and WD Repeat Domain Containing 8 (CUL7/Fbxw8) Ubiquitin Ligase Promotes Degradation of Hematopoietic Progenitor Kinase 1. J Biol Chem 289(7):4009-17, 2/2014. e-Pub 12/2013. PMCID: PMC3924268.
31. Tzeng CW, Tran Cao HS, Lee JE, Pisters PW, Varadhachary GR, Wolff RA, Abbruzzese JL, Crane CH, Evans DB, Wang H, Abbott DE, Vauthey JN, Aloia TA, Fleming JB, Katz MH. Treatment Sequencing for Resectable Pancreatic Cancer: Influence of Early Metastases and Surgical Complications on Multimodality Therapy Completion and Survival. J Gastrointest Surg 18(1):16-24; discussion 24-5, 1/2014. e-Pub 11/2013. PMID: 24241967.
32. Chang Z, Ju H, Ling J, Zhuang Z, Li Z, Wang H, Fleming JB, Freeman JW, Yu D, Huang P, Chiao PJ. Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis. PLoS One 9(7):e101452, 2014. e-Pub 7/16/2014. PMCID: PMC4100754.
33. Ligr M, Wu X, Daniels G, Zhang D, Wang H, Hajdu C, Wang J, Pan R, Pei Z, Zhang L, Melis M, Pincus MR, Saunders JK, Lee P, Xu R. Imbalanced expression of Tif1γ inhibits pancreatic ductal epithelial cell growth. Am J Cancer Res 4(3):196-210, 2014. e-Pub 5/2014. PMCID: PMC4065401.
34. Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, Truty MJ, Chatterjee D, Wang H, Thomas RM, Katz MH, Chiao PJ, Fleming JB. SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium. PLoS One 9(9):e107948, 2014. e-Pub 9/29/2014. PMCID: PMC4180072.
35. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, Colon Cancer Family Registry (CCFR), Stenzel SL, Schumacher FR, Peters U, Gruber SB, Colorectal Transdisciplinary Study (CORECT), Tsugane S, Stram DO, Le Marchand L. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 5:4613, 2014. e-Pub 8/8/2014. PMCID: PMC4180879.
36. Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, Ji B, Huang H, Wang H, Fleming JB, Logsdon CD, Cruz-Monserrate Z. A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology 145(6):1449-58, 12/2013. e-Pub 8/2013. PMCID: PMC3873752.
37. *Zenali M, Overman MJ, Rashid A, Broaddus RB, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Clinicopathologic Features and Prognosis of Duodenal Adenocarcinoma and Comparison with Ampullary and Pancreatic Ductal Adenocarcinoma. Hum Pathol 44(12):2792-8, 12/2013. e-Pub 10/2013. PMID: 24139211.
38. *Chatterjee D, Katz MH, Rashid A, Estrella JS, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB, Wang H. Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology 63(6):841-51, 12/2013. e-Pub 9/2013. PMCID: PMC3836824.
39. *Shroff S, Overman MJ, Rashid A, Shroff RT, Wang H, Chatterjee D, Katz MH, Lee JE, Wolff RA, Abbruzzese JL, Fleming JB, Wang H. The Expression of PTEN is Associated With Improved Prognosis in Patients With Ampullary Adenocarcinoma After Pancreaticoduodenectomy. Arch Pathol Lab Med 137(11):1619-26, 11/2013. PMID: 24168499.
40. Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis. Cell Rep S2211-1247(13):00549-4, 10/2013. PMID: 24209743.
41. Jiang ZQ, Varadhachary G, Wang X, Kopetz S, Lee JE, Wang H, Shroff R, Katz M, Wolff RA, Fleming J, Overman MJ. A retrospective study of ampullary adenocarcinomas: overall survival and responsiveness to fluoropyrimidine-based chemotherapy. Ann Oncol 24(9):2349-53, 9/2013. e-Pub 5/2013. PMCID: PMC3841462.
42. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med 5(9):1322-34, 2013. PMCID: PMC3799489.
43. Huang H, Liu Y, Daniluk J, Gaiser S, Chu J, Wang H, Li ZS, Logsdon CD, Ji B. Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology 144(1):202-10, 2013. PMCID: PMC3769090.
44. Bilen MA, Kim J, Wang H, Tu SM. Cixutumumab-Associated Pancolitis in a Patient With Prostate Cancer. Clin Genitourin Cancer 11(2):207-10, 2013. PMCID: PMC3579009.
45. Bhosale P, Balachandran A, Wang H, Wei W, Hwang RF, Fleming JB, Varadhachary G, Charnsangavej C, Tamm E. CT imaging features of acinar cell carcinoma and its hepatic metastases. Abdom Imaging 28(6):1383-90, 2013. PMID: 23232580.
46. Chang Z, Li Z, Wang X, Kang Y, Yuan Y, Niu J, Wang H, Chatterjee D, Fleming JB, Li M, Abbruzzese JL, Chiao PJ. Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells. Clin Cancer Res 144(1):202-10, 2013. PMCID: PMC3576034.
47. Overman MJ, Zhang J, Kopetz S, Davies M, Jiang Z-Q, Stemke-Hale K, Rümmele P, Pilarsky C, Grützmann R, Hamilton S, Hwang R, Abbruzzese JL, Varadhachary G, Broom B, Wang H. Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome. PLoS One 8(6), 2013. PMCID: PMC3679143.
48. Canto MI, Harinck F, Hruban RH, Offerhaus GJ, Poley JW, Kamel I, Nio Y, Schulick RS, Bassi C, Kluijt I, Levy MJ, Chak A, Fockens P, Goggins M, Bruno M, on behalf of the International Cancer of the Pancreas Screening (CAPS) Consortium. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut 62(3):339-47, 2013. PMCID: PMC3585492.
49. *Liu X, Lee JH, Charnsangavej C, Geng M, Wang H. Long Survival after Resection of Small Cell Carcinoma of the Pancreas with Synchronous Adenocarcinoma of the Ampulla of Vater. American Journal of Clinical Cancer Research Vol 1(Article ID 20130200152), 2013.
50. *Foo WC, Rashid A, Wang H, Katz MH, Lee JE, Pisters PW, Wolff RA, Abbruzzese JL, Fleming JB, Wang H. Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. Hum Pathol 44(6):1024-30, 2013. PMCID: PMC3832989.
51. Liu X, Xie H, Wang H, McMahon J, Patil DT, Yerian LM. Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation. J Med Cases 4(8):544-549, 2013.
52. Abd-Elgaliel WR, Cruz-Monserrate Z, Wang H, Logsdon CD, Tung CH. Pancreatic cancer-associated Cathepsin E as a drug activator. J Control Release 167(3):221-7, 2013. PMCID: PMC3638719.
53. Lewis GH, Wang H, Bellizzi AM, Klein AP, Askin FB, Schwartz LE, Schulick RD, Wolfgang CL, Cameron JL, O'Reilly EM, Yu KH, Hruban RH. Prognosis of Minimally Invasive Carcinoma Arising in Mucinous Cystic Neoplasms of the Pancreas. Am J Surg Pathol 37(4):601-605, 2013. PMCID: PMC3596434.
54. *Li L, Othman M, Rashid A, Wang H, Li Z, Katz MH, Lee JE, Pisters PWT, Abbruzzese JL, Fleming JB, Wang H. Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology 62(3):465-71, 2013. PMCID: PMC3553313.
55. *Zhao Q, Han X-Y, Balachandran A, Wang H. Toxic megacolon and fungal diverticulitis and liver abscess due to Mucor indicus infection in a patient with chronic myelogenous leukemia. American Journal of Clinical Cancer Research Vo1. 1, Article ID 20130200151, 2013.
56. Kim MP, Truty MJ, Choi W, Kang Y, Chopin-Lally X, Gallick GE, Wang H, McConkey DJ, Hwang R, Logsdon C, Abbruzzesse J, Fleming JB. Molecular Profiling of Direct Xenograft Tumors Established from Human Pancreatic Adenocarcinoma After Neoadjuvant Therapy. Ann Surg Oncol Suppl 3:S395-403, 7/2012. e-Pub 6/2011. PMID: 21701930.
57. Daniluk J, Liu Y, Deng D, Chu J, Huang H, Gaiser S, Cruz-Monserrate Z, Wang H, Ji B, Logsdon CD. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 122(4):1519-28, 2012. PMCID: PMC3314459.
58. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21(2):196-211, 2012. PMCID: PMC3760020.
59. Cruz-Monserrate Z, Abd-Elgaliel WR, Grote T, Deng D, Ji B, Arumugam T, Wang H, Tung CH, Logsdon CD. Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models. Gut 61(9):1315-22, 2012. PMCID: PMC3966534.
60. Katz MH, Wang H, Balachandran A, Bhosale P, Crane CH, Wang X, Pisters PW, Lee JE, Vauthey JN, Abdalla EK, Wolff R, Abbruzzese J, Varadhachary G, Chopin-Laly X, Charnsangavej C, Fleming JB. Effect of Neoadjuvant Chemoradiation and Surgical Technique on Recurrence of Localized Pancreatic Cancer. J Gastrointest Surg 16(1):68-78, 2012. PMID: 22065318.
61. *Chatterjee D, Katz MH, Rashid A, Varadhachary GR, Wolff RA, Wang H, Lee JE, Pisters PW, Vauthey JN, Crane C, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome. Cancer 118(12):3182-90, 2012. PMCID: PMC3269538.
62. *Wang J, Estrella JS, Peng L, Rashid A, Varadhachary GR, Wang H, Lee JE, Pisters PW, Vauthey JN, Katz MH, Gomez HF, Evans DB, Abbruzzese JL, Fleming JB, Wang H. Histologic Tumor Involvement of Superior Mesenteric Vein/Portal Vein Predicts Poor Prognosis in Patients with Stage II Pancreatic Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Cancer 118(15):3801-11, 2012. PMCID: PMC3310937.
63. Chang DZ, Ma Y, Ji B, Liu Y, Hwu P, Abbruzzese JL, Logsdon C, Wang H. Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. J Hematol Oncol 5:15, 2012. PMCID: PMC3350393.
64. Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21(1):105-20, 2012. PMCID: PMC3360958.
65. Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol 10(5):e1001326, 2012. PMCID: PMC3348157.
66. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PLoS One 7(8):e42699, 2012. PMCID: PMC3416861.
67. *Weng S, Wang H, Chen W, Katz MH, Chatterjee D, Lee JE, Pisters PW, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Overexpression of Protein Phosphatase 4 Correlates with Poor Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev 21(8):1336-43, 2012. PMCID: PMC3417753.
68. *Zhao Q, Rashid A, Gong Y, Katz MH, Lee JE, Wolf R, Balachandran A, Varadhachary GR, Pisters PW, Wang H, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosis. Ann Diagn Pathol 16(1):29-37, 2012. PMCID: PMC3832988.
69. *Chatterjee D, Katz MH, Rashid A, Wang H, Iuga AC, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Crane CH, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Perineural and Intra-neural Invasion in Posttherapy Pancreaticoduodenectomy Specimens Predicts Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma. Am J Surg Pathol 36(3):409-17, 2012. PMCID: PMC3288807.
70. *Estrella JS, Rashid A, Fleming JB, Katz MH, Lee JE, Wolf RA, Varadhachary GR, Pisters PW, Abdalla EK, Vauthey JN, Wang H, Gomez HF, Evans DB, Abbruzzese JL, Wang H. Posttherapy Pathologic Stage and Survival in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Cancer 118(1):268-77, 2012. PMID: 21735446.
71. Katz MH, Fleming JB, Bhosale P, Varadhachary G, Lee JE, Wolff R, Wang H, Abbruzzese J, Pisters PW, Vauthey JN, Charnsangavej C, Tamm E, Crane CH, Balachandran A. Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators. Cancer 118(23):5749-56, 2012. PMID: 22605518.
72. Thomas RM, Truty MJ, Nogueras-Gonzalez GM, Fleming JB, Vauthey JN, Pisters PW, Lee JE, Rice DC, Hofstetter WL, Wolff RA, Varadhachary GR, Wang H, Katz MH. Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection. J Gastrointest Surg 16(9):1696-704, 2012. PMCID: PMC3884897.
73. Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21(3):374-87, 2012. PMCID: PMC3350095.
74. *Chatterjee D, Rashid A, Wang H, Katz MH, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy. Am J Surg Pathol 36(4):552-9, 2012. PMCID: PMC3310954.
75. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor suppressor activity mediated by regulation of COP1 stability. Cancer Res 71(3):884-94, 2011. PMCID: PMC3358120.
76. Dickson PV, Rich TA, Xing Y, Cote GJ, Wang H, Perrier ND, Evans DB, Lee JE, Grubbs EG. Achieving eugastrinemia in MEN1 patients: Both duodenal inspection and formal lymph node dissection are important. Surgery 150(6):1143-52, 2011. PMID: 22136834.
77. Kim MP, Fleming JB, Wang H, Abbruzzese JL, Choi W, Kopetz S, McConkey DJ, Evans DB, Gallick GE. ALDH Activity Selectively Defines an Enhanced Tumor-Initiating Cell Population Relative to CD133 Expression in Human Pancreatic Adenocarcinoma. PLoS One 6(6):e20636, 2011. e-Pub 6/2011. PMCID: PMC3113804.
78. Yang Q, Wang H, Cho HY, Jung SJ, Kim KR, Ro JY, Shen SS. Carcinoma of müllerian origin presenting as colorectal cancer: a clinicopathologic study of 13 Cases. Ann Diagn Pathol 15(1):12-8, 2011. PMID: 20970364.
79. Varadhachary GR, Spector Y, Abbruzzese JL, Rosenwald S, Wang H, Aharonov R, Carlson HR, Cohen D, Karanth S, Macinskas J, Lenzi R, Chajut A, Edmonston TB, Raber MN. Prospective Gene Signature Study Using microRNA to Identify the Tissue of Origin in Patients with Carcinoma of Unknown Primary (CUP). Clin Cancer Res 17(12):4063-70, 2011. PMID: 21531815.
80. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 2011. PMCID: PMC3049400.
81. Arumugam T, Brandt W, Ramachandran V, Moore TT, Wang H, May FE, Westley BR, Hwang RF, Logsdon CD. Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis. Pancreas 40(6):815-22, 2011. PMID: 21747314.
82. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res 16(12):3171-81, 2010. PMCID: PMC2930838.
83. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A 107(34):15193-8, 2010. PMCID: PMC2930541.
84. *Liang JJ, Zhu S, Bruggeman R, Zaino RJ, Evans DB, Fleming JB, Gomez HF, Zander DS, Wang H. High levels of expression of human stromal cell-derived factor-1 are associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 19(10):2598-604, 2010. PMID: 20732965.
85. *Peng L, Liang J, Wang H, Song X, Rashid A, Gomez HF, Corley LJ, Abbruzzese JL, Fleming JB, Evans DB, Wang H. High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin Cancer Res 16(14):3734-42, 2010. PMID: 20628027.
86. Overman MJ, Pozadzides J, Kopetz S, Wen S, Abbruzzese JL, Wolff RA, Wang H. Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer 102(1):144-50, 2010. PMCID: PMC2813754.
87. Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Res 70(17):6824-36, 2010. PMCID: PMC2988472.
88. *Fang X, Gupta N, Shen SS, Tamboli P, Charnsangavej C, Rashid A, Wang H. Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polyp. Arch Pathol Lab Med 134(7):1003-9, 2010. PMID: 20586628.
89. Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer. Gastroenterology 139(6):2135-45, 2010. PMCID: PMC3245983.
90. *Abadeer RA, Fleming JB, Deavers MT, Rashid A, Evans DB, Wang H. Metastatic adult granulosa cell tumor mimicking a benign pancreatic cyst. Ann Diagn Pathol 14(6):457-60, 2010. PMID: 21074697.
91. *Song X, Wang H, Logsdon CD, Rashid A, Fleming JB, Abbruzzese JL, Gomez HF, Evans DB, Wang H. Overexpression of receptor tyrosine kinase axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. Cancer 117(4):734-43, 2010. PMID: 20922806.
92. Overman MJ, Maru DM, Charnsangavej C, Loyer EM, Wang H, Pathak P, Eng C, Hoff PM, Vauthey JN, Wolff RA, Kopetz S. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury. J Clin Oncol 28(15):2549-55, 2010. PMID: 20406923.
93. Katz MH, Varadhachary GR, Fleming JB, Wolff RA, Lee JE, Pisters PW, Vauthey JN, Abdalla EK, Sun CC, Wang H, Crane CH, Lee JH, Tamm EP, Abbruzzese JL, Evans DB. Serum CA 19-9 as a Marker of Resectability and Survival in Patients with Potentially Resectable Pancreatic Cancer Treated with Neoadjuvant Chemoradiation. Ann Surg Oncol 17(7):1794-801, 2010. PMCID: PMC2889288.
94. Rubbia-Brandt L, Lauwers GY, Wang H, Majno PE, Tanabe K, Zhu AX, Brezault C, Soubrane O, Abdalla EK, Vauthey JN, Mentha G, Terris B. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology 56(4):430-9, 2010. PMID: 20459550.
95. Higgins RJ, Dickinson PJ, LeCouteur RA, Bollen AW, Wang H, Wang H, Corely LJ, Moore LM, Zang W, Fuller GN. Spontaneous canine gliomas: overexpression of EGFR, PDGFRalpha and IGFBP2 demonstrated by tissue microarray immunophenotyping. J Neurooncol 98(1):49-55, 2010. PMID: 19967449.
96. Maru DM, Kopetz S, Boonsirikamchai P, Agarwal A, Chun YS, Wang H, Abdalla EK, Kaur H, Charnsangavej C, Vauthey JN, Loyer EM. Tumor thickness at the tumor-normal interface: a novel pathologic indicator of chemotherapy response in hepatic colorectal metastases. Am J Surg Pathol 34(9):1287-94, 2010. PMID: 20697255.
97. Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL, Gallick GE, Logsdon CD, McConkey DJ, Choi W. Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer. Cancer Res 69(14):5820-8, 7/2009. e-Pub 7/2009. PMID: 19584296.
98. Yu W, Liu J, Xiong X, Ai Y, Wang H. Expression of MMP9 and CD147 in invasive squamous cell carcinoma of the uterine cervix and their implication. Pathology - Research and Practice 205(10):709-15, 2009.
99. Kim MP, Fleming JB, Wang H, Abbruzzese JL, and Gallick GE. Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. Nature Protocols 4(11):1670-80, 2009.
100. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated upregulation of Pim-1 contributes to solid tumor formation. Am J Pathol 175(1):400-11, 2009.
101. Katz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol 16(4):836-47, 2009.
102. *Wang H, Song X, Logsdon C, Zhou G, Evans DB, Abbruzzese JL, Hamilton SR, Tan T-H, Wang H. Proteasome mediated degradation and the functions of hematopoietic progenitor kinase-1 in pancreatic cancer. Cancer Research 69(3):1063-70, 2009. PMID: 19141650.
103. Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, Daniluk J, Bi Y, Grote T, Longnecker DS and Logsdon CD. Ras activity levels control the development of pancreatic diseases. Gastroenterology 137(3):1072-82, 2009. PMID: 19501586.
104. Dong X, Jiao L, Li Y, Evans DB, Wang H, Hess KR, Abbruzzese JL, Li D. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. Journal of Clinical Oncology 27(10):1592-9, 2009.
105. *Li J, Wang H, Fuller GN, May S, Wang H. Activation of c-Jun N-terminal kinase correlates with the histologic grade and EGFR expression in diffuse gliomas. J Neurooncol 88(1):11-7, 2008. PMID: 18246408.
106. Ramachandran V, Arumugam T, Wang H, and Logsdon CD. Anterior gradient 2 (AGR2) is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival. Cancer Research 68(19):7811-8, 2008. PMID: 18829536.
107. Miller DV, Wang H, Wang H, Fealey ME, Tazelaar HD. Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. Pediatr Dev Pathol 11(4):291-4, 2008. PMID: 18078366.
108. *Sanchez AA, Wu T-T, Prieto VG, Rashid A, and Wang H. Comparison of primary and metastatic malignant melanoma of the esophagus: clinicopathologic review of 10 cases. Arch Path Lab Med 132(10):1623-29, 2008. PMID: 18834221.
109. Hwang RF, Wang H, Lara A, Gomez H, Chang T, Sieffert N, Moon Y, Ram S, Zimmerman S, Lee JH, Pisters PW, Tamm EP, Fleming JB, Abbruzzese JL, Evans DB. Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer. Ann Surg Oncol 15(5):1356-66, 2008. PMID: 18256882.
110. Blazer DG 3rd, Ramirez PT, Wang H, Fleming JB. Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas. J Pancreas 9(1):56-60, 2008. PMID: 18182745.
111. *Liang JJ, Wang H, Rashid A, Tan T-H, Hwang RF, Hamilton SR, Abbruzzese JL, Evans DB and Wang H. Expression of MAP4K4 is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 14(21):7043-9, 2008. PMID: 18981001.
112. Baker AF, Koh MY, Williams RR, James B, Wang H, Tate WR, Gallegos A, Von Hoff DD, Han H, Powis G. Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer. Pancreas 36(2):178-86, 2008. PMID: 18376310.
113. Wang H, Arun BK, Wang H, Fuller GN, Zhang W, Middleton LP, and Sahin A. IGFBP2 and IGFBP5 overexpression is associated to metastasis in T1 breast carcinomas. The Breast Journal 14(3):261-7, 2008. PMID: 18373644.
114. Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB, Bast RC Jr, Hortobagyi GN and Hung M-C. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian and pancreatic cancers. Mol Carcinog 47(9):701-6, 2008. PMID: 18176935.
115. Dallas NA, Gray MJ, Xia L, Fan F, van Buren G 2nd, Gaur P, Samuel S, Lim SJ, Arumugam T, Ramachandran V, Wang H, Ellis LM. Neuropilin-2-Mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clinical Cancer Research 14(24):8052-60, 2008.
116. Tong Z, Kunnumakkara A, Wang H, Matsuo Y, Diagaradjane P, Harikumar K, Ramachandran V, Sung B, Chakraborty A, Bresalier R, Logsdon C, Aggarwal B, Krishnan S, Guha S. Neutrophil Gelatinase-Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer. Cancer Research 68(15):6100-8, 2008.
117. Abraham SC, Wang H, Wang KK, Wu T-T. Paget's Cells in the Esophagus: Assessment of Their Histopathologic Features and Near-Universal Association with Underlying Esophageal Adenocarcinoma. Am J of Surg Pathol 32(7):1068-74, 2008.
118. Blazer DG 3rd, Kishi Y, Maru DM, Kopetz S, Overman M, Folgelman D, Eng C, Chang DZ, Wang H, Zorzi D, Ribero D, Ellis LM, Clover K, Wolff RA, Curley SA, Abdalla EK and Vauthey J-N. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. Journal of Clinical Oncology 26(33):5344-51, 2008.
119. Varadhachary GR, Wolff RA, Crane CH, Sun CC, Lee JE, Pisters PW, Vauthey JN, Abdalla E, Wang H, Staerkel GA, Lee JH, Ross WA, Tamm EP, Bhosale PR, Krishnan S, Das P, Ho L, Xiong H, Abbruzzese JL, Evans DB. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. Journal of Clinical Oncology 26(21):3487-95, 2008.
120. Evans DB, Varadhachary GR, Crane CH, Sun CC, Lee JE, Pisters PW, Vauthey JN, Wang H, Cleary KR, Staerkel GA, Charnsangavej C, Lano EA, Ho L, Lenzi R, Abbruzzese JL, and Wolff RA. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. Journal of Clinical Oncology 26(21):3496-502, 2008.
121. Lim SJ, Feig BW, Wang H, Hunt KK, Rodriguez-Bigas MA, Skibber JS, Ellis V, Cleary K, and Chang GJ. Sentinel lymph node evaluation does not improve staging accuracy in colon cancer (60th Annual Best Clinical Paper Award, the Society of Surgical Oncology, 2007). Ann Surg Oncol 15(1):46-51, 2008.
122. Verma A, Guha S, Wang H, Fok JY, Koul D, Abbruzzese J, and Mehta K. Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res 14(7):1997-2005, 2008.
123. Weixel KM, Edinger RS, Kester L, Guerriero CJ, Wang H, Fang L, Kleyman TR, Welling PA, Weisz OA, Johnson JP. Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells. J Biol Chem 282(50):36534-42, 12/14/2007. e-Pub 10/16/2007. PMID: 17940289.
124. Hill WG, Butterworth MB, Wang H, Edinger RS, Lebowitz J, Peters KW, Frizzell RA, Johnson JP. The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells. J Biol Chem 282(52):37402-11, 12/28/2007. e-Pub 10/10/2007. PMID: 17932048.
125. Wang H, Wang Y, Chen J, Zhan Z, Li Y, Xu J. Oral yeast flora and its ITS sequence diversity among a large cohort of medical students in Hainan, China. Mycopathologia 164(2):65-72, 8/2007. e-Pub 6/6/2007. PMID: 17551847.
126. Ribero D, Wang H, Donadon M, Zorzi D, Thomas MB, Eng C, Chang DZ, Curley SA, Aballa EK, Ellis LM, Vauthey JN. Bevacizumab Increases the Pathological Response and Reduces the Hepatic Injury in Patients Treated with Oxaliplatin-based Chemotherapy for Colorectal Liver Metastases. Cancer 110(12):2761-7, 2007.
127. Wu T-T, Chirieac LR, Abraham SC, Krasinskas A, Wang H, Rashid A, Correa AM, Hofstetter WL, Ajani JA, Swisher SG. Excellent interobserver agreement on grading the extent of residual carcinoma following preoperative chemoradiation in esophageal and esophagogastric junction carcinoma: A reliable predictor for patient outcome. Am J of Surg Pathol 31(1):58-64, 2007. PMID: 17197919.
128. Wang KL, Wu TT, Choi IS, Wang H, Reseetkova E, Correa AM, Hofstetter WL, Swisher SG, Ajani JA, Rashid A, Albarracin CT. Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Cancer 109(4):658-67, 2007. PMID: 17211865.
129. Baruch AC, Wang H, Staerkel GA, Evans DB, Hwang RF, Krishnamurthy S. Immunocytochemical study of the expression of mesothelin in fine-needle aspiration biopsy specimens of pancreatic adenocarcinoma. Diagn Cytopathol 35(3):143-7, 2007. PMID: 17304533.
130. Raut CP, Tseng JF, Sun CC, Wang H, Wolff RA, Crane CH, Hwang R, Vauthey J-N, Abdalla EK, Lee JE, Pisters PWT, and Evans DB. Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg 246(1):52-60, 2007. PMID: 17592291.
131. Wang H and Silva E. Metastatic well-differentiated mucinous adenocarcinoma consistent with pseudomyxoma peritonei. CAP Check Samples 35(8):89-99, 2007. PMID: 7750935.
132. Tseng JF, Pisters PW, Lee JE, Wang H, Gomez HF, Sun CC, Evans DB. The learning curve in pancreatic surgery. Surgery 141(5):694-701, 2007. PMID: 17511115.
133. Yuan P, Wang L, Wei D, Zhang J, Jia Z, Li Q, Le X, Wang H, Yao J. and Xie K. Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin A correlates directly with a potent antiangiogenic effects on human pancreatic cancer. Cancer 110(12):2682-90, 2007. PMID: 17973266.
134. Varadhachary GR, Tamm EP, Abbruzzese JL, Xiong HQ, Crane CH, Wang H, Lee JE, Pisters PW, Evans DB, Wolff RA. Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol 13(8):1035-46, 8/2006. e-Pub 7/24/2006. PMID: 16865597.
135. Wang H, Traub LM, Weixel KM, Hawryluk MJ, Shah N, Edinger RS, Perry CJ, Kester L, Butterworth MB, Peters KW, Kleyman TR, Frizzell RA, Johnson JP. Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin. J Biol Chem 281(20):14129-35, 5/19/2006. e-Pub 3/30/2006. PMID: 16574660.
136. Wang KL, Wu TT, Resetkova E, Wang H, Correa AM, Hofstetter WL, Swisher SG, Ajani JA, Rashid A, Hamilton SR, Albarracin CT. Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome. Clin Cancer Res 12(15):4598-604, 2006. PMID: 16899607.
137. Verma A, Wang H, Manavathi B, Fok JY, Mann AP, Kumar R, Mehta K. Increased Expression of Tissue Transglutaminase in Pancreatic Ductal Adenocarcinoma and Its Implications in Drug Resistance and Metastasis. Cancer Res 66(21):10525-33, 2006. PMID: 17079475.
138. Wang H, Rosen DG, Wang H, Fuller GN, Zhang W, Liu J. Insulin-like growth factor binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types. Mod Pathol 19(9):1149-56, 2006. PMID: 16729015.
139. Wang H, Wang H, Zhang W, Fuller GN. Overexpression of IGFBP5, but not IGFBP3 correlates with the histologic grade of human diffuse glioma: A tissue microarray and immunohistochemical study. Technol Cancer Res Treat 5(3):195-9, 2006. PMID: 16700616.
140. Mann AP, Verma A, Sethi G, Manavathi B, Wang H, Fok JY, Kumar R, Aggarwal BB, Mehta K. Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor kB in cancer cells: Delineation of a novel pathway. Cancer Res 66(17):8788-95, 2006.
141. Mullen JT, Wang H, Yao JC, Lee JH, Perrier ND, Pisters PWT, Lee JE, and Evans DB. Carcinoid tumors of the duodenum. Surgery 138(6):871-8, 2005.
142. Lee E-J, Mircean C, Shmulevich I, Wang H, Liu J, Niemisto A, Kavanagh JJ, Lee J-H, and Zhang W. Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion. Mol Cancer 4(7), 2005.
143. Heimberger AB, McGary EC, Suki D, Ruiz M, Wang H, Fuller GN, Bar-Eli M. Loss of the AP-2alpha transcription factor is associated with the grade of human gliomas. Clin Cancer Res 11(1):267-72, 2005. PMID: 15671555.
144. Wang H, Wang H, Zhang W, Huang H, Liao W, and Fuller G N. Analysis of the activation status of Akt, NFkB and Stat3 in human diffuse gliomas. Laboratory Investigation 84(8):941-51, 2004.
145. Hao X, Sun B, Hu L, Lahdesmaki H, Dunmire V, Feng Y, Zhang SW, Wang H, Wu C, Wang H, Fuller GN, Symmans WF, Shmulevich I, Zhang W. Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis. Cancer 100(6):1110-22, 2004. PMID: 15022276.
146. Wang H, Shen SS, Wang H, Diwan AH, Zhang W, Fuller GN, Prieto VG. Expression of insulin-like growth factor-binding protein 2 in melanocytic lesions. J Cutan Pathol 30(10):599-605, 11/2003. PMID: 14744083.
147. Wang H, Wang X, Jiang Y. Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases. Mol Biol Cell 14(11):4342-51, 11/2003. e-Pub 7/25/2003. PMCID: PMC266755.
148. Wang H, Jiang Y. The Tap42-protein phosphatase type 2A catalytic subunit complex is required for cell cycle-dependent distribution of actin in yeast. Mol Cell Biol 23(9):3116-25, 5/2003. PMCID: PMC153200.
149. Wang H, Actor JK, Indrigo J, Olsen M, Dasgupta A. Asian and Siberian ginseng as a potential modulator of immune function: an in vitro cytokine study using mouse macrophages. (Paul E. Strandjord Young Investigator Award, 6/2006). Clin Chim Acta 327:123-8, 2003. PMID: 12482627.
150. Wang H, Wang H, Shen W, Huang H, Hu L, Ramdas L, Zhou Y, Liao WSL, Fuller GN, Zhang W. Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion enhancing genes. Cancer Research 63:4315-4321, 2003. PMID: 12907597.
151. Fuller CE, Wang H, Zhang W, Fuller GN, Perry A. High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH). J Neuropathol Exp Neurol 61(12):1078-84, 12/2002. PMID: 12484570.
152. Davis AT, Wang H, Zhang P, Ahmed K. Heat shock mediated modulation of protein kinase CK2 in the nuclear matrix. J Cell Biochem 85(3):583-91, 2002. PMID: 11967998.
153. Casella R, Nudell D, Cozzolino D, Wang H, Lipshultz LI. Primary testicular amyloidosis mimicking tumor in a cryptorchid testis. Urology 59(3):445, 2002. PMID: 11880098.
154. Wang H, Napoli KL, Strobel HW. Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. Mol Cell Biochem 213(1-2):127-35, 10/2000. PMID: 11129951.
155. Rowlands JC, Wang H, Hakkak R, Ronis MJ, Strobel HW, Badger TM. Chronic intragastric infusion of ethanol-containing diets induces CYP3A9 while decreasing CYP3A2 in male rats. J Pharmacol Exp Ther 295:747-52, 2000. PMID: 11046114.
156. Kelly PA, Wang H, Napoli KL, Kahan BD, Strobel HW. Metabolism of cyclosporine by cytochromes P450 3A9 and 3A4. Eur J Drug Metab Pharmacokinet 24(4):321-8, 1999. PMID: 10892895.
157. Wang H, Strobel HW. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Arch Biochem Biophys 344(2):365-72, 1997. PMID: 9264551.
158. Wang H, Kawashima H, Strobel HW. cDNA cloning of a novel CYP3A from rat brain. Biochem Biophys Res Commun 221(1):157-62, 4/1996. PMID: 8660328.
159. Tao Y, Wang H, Fu Y, Yin C, and Xu F. Epidemiological studies on the effect of drinking natural mineral water on human health in Wen Tang. Journal of Environment and Health 9(3):101-3, 1992.
160. Wang S, Zhang X, Li H, Song S, Luo J, Yang Y, and Wang H. Health effect and economic loss resulting from the environment pollution caused by small electroplating plants. Journal of Hygiene Research 21:38-42, 1992.
161. Chen X, Lin P, Lu Y, Cang G, Wu C, Guo R, Zhao Y, Wu X, and Wang H. Health effect and economic loss resulting from the environment pollution caused by small township smelteries of lead. Journal of Hygiene Research 21:28-33, 1992.
162. Chen X, Lu Y, Lin P, Cang G, Wu C, Gan Y, Sun R, Wu X, and Wang H. Health effect and economic loss resulting from the environment pollution caused by township printing and dyeing mills. Journal of Hygiene Research 21:24-27, 1992.
163. Xu F, Wang H, and Cao Z. Research on economic analysis and strategy to the effect of the environment pollution of township industries on human health. Journal of Hygiene Research 21:1-23, 1992.
164. Zhao D, Yang Z, Wang H, and Cao Z. Studies on the environment pollution caused by township asphalt felt plants: its health effect, economic analysis and preventive strategies. Journal of Hygiene Research 21:65-68, 1992.
165. Zhao D, Yang Z, Wang H, Cao Z. Studies on the environment pollution caused by township cement plants: its health effect, economic analysis and preventive strategies. Journal of Hygiene Research 21:68-71, 1992.
166. Fu Y, Wu X, Cao Z, Wang H, and Yin C. The effect of air pollution caused by the sulfur-smelting with local methods on the health of school children. China Public Health 8(11):487-8, 1992.
167. Tao Y, Wang H, Liu J, Tan Y, and Li W. Utilization of geothermal water and its effect on human health. Journal of Hygiene Research 21(1):21-3, 1992.
168. Qin Y, Guo R, Yin X, Song X, Wu Z, Shen S, Wang H, and Li S. Studies on the subchronic toxicity of dimethyl fumarate. Journal of Hygiene Research 20(2):23-25, 1991.
169. Yin C and Wang H. A method for the determination of SIgA in saliva. Journal of Hygiene Research 19(6):22-24, 1990.
170. Li S, Liu J, Tan Y, Fu J, Yin C, Wang H, Wang X, Shen S, Li J, Song X, and Xu F. Investigation on the status of air pollution around poultry farms. China Public Health 6(1):7-8, 1990.
171. Li S, Liu J, Tan Y, Fu J, Yin C, Wang H, and Xu F. Studies on health protection zone around large-scale poultry farms. China Public Health 6(9):397-397, 1990.
172. Wang H, Yin C, Fu Y, and Xu F. Sulphur-smelting with local methods of rural industries impacts on the level of SIgA in school children saliva. Chinese Journal of Public Health 8(6):378-379, 1990.
173. Li G, Xu Z, Tan Y, Wang H. Smoking and lung cancer in seven cities of Liaoning Province. Journal of Environment and Health 6(5):1-4, 1989.
174. *Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Ji B, Logsdon C, Jin J, Abbruzzese JL, Tan T-H, Wang H. Fbxw8 Targets Hematopoietic Progenitor Kinase 1 for Proteasomal Degradation in Pancreatic Cancer. GUT. Submitted.

Invited Articles

1. Dhingra S, Wang H. Non-neoplastic Signet Ring Cell Change in Gastrointestinal and Biliary Tract: A Pitfall for Overdiagnosis. Ann Diagn Pathol 15(6):490-6, 12/2011. PMID: 22082777.
2. Katz MH, Mortenson MM, Wang H, Hwang R, Tamm EP, Staerkel G, Lee JH, Evans DB, Fleming JB. Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approach. J Am Coll Surg 207(1):106-120, 7/2008. e-Pub 4/24/2008. PMID: 18589369.
3. Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB. Current diagnosis and management of unusual pancreatic tumors. American Journal of Surgery 196(1):100-113, 2008.
4. Akkiprik M, Feng Y, Wang H, Chen K, Hu L, Sahin A, Krishnamurthy S, Ozer A, Hao X, Zhang W. Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer. Breast Cancer Res 10(4):212, 2008. PMCID: PMC2575530.
5. Varadhachary GR, Tamm EP, Abbruzzese JL, Crane CH, Wang H, Lee JE, Pisters PWT, Evans DB, and Wolff RA. Borderline resectable pancreatic Cancer: definitions, management, and the role of preoperative therapy. Annals of Surgical Oncology 13(8):1035-46, 2006.
6. Wang H, Medeiros LJ, Jones D. Subcutaneous panniculitis-like T-cell lymphoma. Clin Lymphoma 3(3):181-3, 12/2002. PMID: 12521397.
7. Wang H, Wang H, Zhang W, Fuller GN. Tissue microarrays: applications in neuropathology research, diagnosis, and education. Brain Pathol 12(1):95-107, 2002. PMID: 11770905.
8. Strobel HW, Geng J, Kawashima H, Wang H. Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue. Drug Metab Rev 29(4):1079-105, 1997. PMID: 9421686.
9. Strobel HW, Kawashima H, Geng J, Sequeira D, Bergh A, Hodgson AV, Wang H, Shen S. Expression of multiple forms of brain cytochrome P450. Toxicol Lett 82-83:639-43, 1995. PMID: 8597121.

Letters to the Editor

1. Overman M, Wang H, Varadhachary GR. Adjuvant chemotherapy for resected periampullary adenocarcinoma. Author Reply 1855-6. JAMA 308(18):1855; author reply 1855-6, 11/2012. PMID: 23149995.
2. Wang H, Zhao Q. Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with better prognosis. Author Reply. Ann Diagn Pathol 16(5):427, 10/2012. e-Pub 5/2012. PMID: 22561135.
3. Overman MJ, Wolff RA, Wang H. Reply to comment: Cetuximab in small bowel adenocarinoma (SBA): a new friend? British Journal of Cancer 103(8):1306, 10/2010. PMCID: PMCPMC2967067.

Grant & Contract Support

Title: The KillRas Flagship Project
Funding Source: The Pancreas Cancer Moon Shot Program, MDACC
Role: Co-Investigator
Principal Investigator: Maitra A., Fleming JB, & Wolff RA
Duration: 9/1/2014 - 8/31/2015
 
Title: Biomarkers for early detection of pancreatic cancer. Core fund to U01 (CA111302)
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Subrata Sen
Duration: 8/2014 - 7/2015
 
Title: Discovery of Risk Loci and Genomics of Pancreatic Cancer through Exome Sequencing
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Paul Scheet
Duration: 7/11/2014 - 5/31/2019
 
Title: Development of Tissue Microarrays for Pancreatic Cancer and Pancreatic Precursor Lesions
Funding Source: Khalifa Bin Zayed Al Nahyan Foundation Institute For Pancreatic Cancer Research, The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2013 - 6/30/2015
 
Title: Hematopoietic Progenitor Kinase 1: A Novel Negative Regulator of Ras Signaling in Pancreatic Cancer
Funding Source: G. S. Hogan Gastrointestinal Cancer Research Fund, The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2015
 
Title: A Novel Preoperative Platform in Pancreatic Cancer for Mechanistic Studies
Funding Source: Lustgarten Foundation for Pancreatic Cancer
Role: Co-Investigator
Principal Investigator: Gauri Varadhachary
Duration: 5/1/2011 - 4/30/2015
 
Title: Proteasome-medicated Degradation of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2011 - 3/31/2014
 
Title: Conditional ablation of stellate cells to determine their role in pancreatitis and pancreatic cancer
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Rosa Hwang
Duration: 12/1/2010 - 11/30/2012
 
Title: Stellate cell-specific targeting in pancreatic cancer
Funding Source: American Association for Cancer Research (AACR) - PanCAN, Innovative Grant
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 7/1/2010 - 6/30/2012
 
Title: Role of Dietary Zinc Transporter ZIP4 in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Min Li
Duration: 4/2010 - 1/2015
 
Title: Wnt signaling in pancreatic cancer associated-stroma
Funding Source: The Lustgarten Foundation
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 1/1/2010 - 12/31/2010
 
Title: Stromal Periostin in Pancreatitis and Pancreas Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Rosa Hwang
Duration: 12/1/2009 - 11/30/2014
 
Title: Roles of MicroRNAs and Ultraconserved Genes in Pancreatic Cancers
Funding Source: American Association for Cancer Research (AACR)
Role: Co-Investigator
Principal Investigator: Calin, G
Duration: 7/1/2009 - 6/30/2011
 
Title: Functions of ubiquitin E3 ligase, Fbw8, in proteasome-mediated degradation of hematopoietic progenitor kinase 1 in pancreatic cancer
Funding Source: Institutional Research Grant (Basic Laboratory Research), The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2009 - 6/30/2010
 
Title: KLF4 Genetic and epigenetic changes in human pancreatic cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xie, Keping
Duration: 9/2008 - 7/2013
 
Title: Survivin and interferon as a cancer vaccine for pancreatic cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Chang, David Z.
Duration: 9/2008 - 8/2010
 
Title: Lockton Grant Matching Program for Pancreatic Cancer Research, M. D. Anderson Cancer Center
Funding Source: The University of Texas M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2008 - 12/31/2008
 
Title: Functional study of hematopoietic progenitor kinase-1 (HPK1) in pancreatic cancer
Funding Source: American Association for Cancer Research-PanCAN Career Development Award
Role: Principal Investigator
Duration: 7/1/2007 - 6/30/2010
 
Title: Clinicopathologic characteristics and molecular alterations of pancreatic ductal adenocarcinoma in patients of 45 years of age and younger
Funding Source: Fellow's Intramural Research Grant/The University of Texas M.D. Anderson Cancer Center
Role: Mentor for FY06-07 Fellow Research Project Award (Fellow: John Liang, MD, PhD)
Principal Investigator: John J. Liang
Duration: 7/1/2006 - 6/30/2007
 
Title: Genetics and Biology of Pancreatic Ductal Adenocarcinoma
Funding Source: NIH/NCI
Role: Core PI
Principal Investigator: Ronald DePinho
Duration: 4/15/2006 - 12/31/2015
 
Title: Pancreatic Cancer Tissue core. Specialized Program of Research Excellence (SPORE) in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: James L. Abbruzzese
Duration: 9/30/2003 - 8/31/2008
 
Title: Prognostic significance of insulin-like growth factor binding proteins in breast and ovarian cancers
Funding Source: Fellow's Intramural Research Grant/The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 7/1/2003 - 6/30/2004

Last updated: 7/13/2015