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Issam I Raad, MD, FACP, FIDSA, FSHEA

Present Title & Affiliation

Primary Appointment

Department Chair, Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Gerald P. Bodey, Sr. Distinguished Professor, Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Houston, TX 77030

Education & Training

Degree-Granting Education

1982 American University of Beirut, Beirut, Lebanon, MD, Medicine
1977 Anderson University, Anderson, IN, BA, Chemistry and Biology
1976 American University of Beirut - School of Arts & Sciences, Beirut, Lebanon, Undergraduate, General
1974 International College, Beirut, Lebanon, Undergraduate, Lebanese Baccalaureate

Board Certifications

12/2010 American Board of Internal Medicine - Infectious Diseases
12/2000 American Board of Internal Medicine - Infectious Diseases
1/1990 American Board of Internal Medicine – Infectious Diseases
1/1988 American Board of Internal Medicine - Internal Medicine

Selected Publications

Peer-Reviewed Original Research Articles

1. Chemaly RF, Torres HA, Hachem R, Kontoyiannis DP, Safdar A, Raad II. Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection. Haematologica 93(1):157-8, 1/2008. PMID: 18166808.
2. Hachem RY, Boktour MR, Hanna HA, Husni RN, Torres HA, Afif C, Kontoyiannis DP, Raad II. Amphotericin B lipid complex versus liposomal amphotericin B monotherapy for invasive aspergillosis in patients with hematologic malignancy. Cancer 112(6):1282-7, 3/15/2008. PMID: 18224662.
3. Raad II, Hanna HA, Boktour M, Jiang Y, Torres HA, Afif C, Kontoyiannis DP, Hachem RY. Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin. Leukemia 22(3):496-503, 3/2008. PMID: 18094720.
4. Raad II, Fang X, Keutgen XM, Jiang Y, Sherertz R, Hachem R. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr Opin Infect Dis 21(4):385-92, 8/2008. PMID: 18594291.
5. Hachem RY, Langston AA, Graybill JR, Perfect JR, Pedicone LD, Patino H, Raad II. Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment. J Antimicrob Chemother 62(6). e-Pub 10/3/2008. PMID: 18835806.
6. Ghanem G, Hachem RY, Chemaly RF, Dvorak T, Hulten K, Graviss L, Raad II. The role of molecular methods in the prevention of nosocomial methicillin-resistant Staphylococcus aureus clusters in cancer patients. Am J Infect Control 36(9). e-Pub 10/3/2008. PMID: 18834742.
7. Hachem RY, Kontoyiannis DP, Chemaly RF, Jiang Y, Reitzel R, Raad I. Utility of galactomannan enzyme immunoassay and (1,3) beta-D-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients. J Clin Microbiol 47(1). e-Pub 11/12/2008. PMCID: PMC2620882.
8. Raad II, Hachem RY, Hanna HA, Fang X, Jiang Y, Dvorak T, Sherertz RJ, Kontoyiannis DP. Role of ethylene diamine tetra-acetic acid (EDTA) in catheter lock solutions: EDTA enhances the antifungal activity of amphotericin B lipid complex against Candida embedded in biofilm. Int J Antimicrob Agents 32(6):515-8, 12/2008. e-Pub 9/9/2008. PMID: 18783924.
9. Hachem RY, Boktour MR, Hanna HA, Husni R, Hanna EY, Keutgen X, Shukrallah B, Raad II. Sinus surgery combined with antifungal therapy is effective in the treatment of invasive Aspergillus sinusitis in neutropenic patients with cancer. Infection 36(6):539-42, 12/2008. e-Pub 8/25/2008. PMID: 18726553.
10. Adachi JA, Perego C, Graviss L, Dvorak T, Hachem R, Chemaly RF, Raad II. The role of interventional molecular epidemiology in controlling clonal clusters of multidrug resistant Pseudomonas aeruginosa in critically ill cancer patients. Am J Infect Control 37(6). e-Pub 12/31/2008. PMID: 19118923.
11. Reitzel RA, Dvorak TL, Hachem RY, Fang X, Jiang Y, Raad I. Efficacy of novel antimicrobial gloves impregnated with antiseptic dyes in preventing the adherence of multidrug-resistant nosocomial pathogens. Am J Infect Control 37(4). e-Pub 1/19/2009. PMID: 19155100.
12. Ramos ER, Hachem R, Youssef S, Fang X, Jiang Y, Raad I. The crucial role of catheters in micrococcal bloodstream infections in cancer patients. Infect Control Hosp Epidemiol 30(1):83-5, 1/2009. PMID: 19046050.
13. Kassar R, Hachem R, Jiang Y, Chaftari AM, Raad I. Management of Bacillus bacteremia: the need for catheter removal. Medicine (Baltimore) 88(5):279-83, 9/2009. PMID: 19745686.
14. Sipsas NV, Lewis RE, Tarrand J, Hachem R, Rolston KV, Raad II, Kontoyiannis DP. Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001-2007): stable incidence but changing epidemiology of a still frequently lethal infection. Cancer 115(20):4745-52, 10/15/2009. e-Pub 7/24/2009. PMID: 19634156.
15. Kassis C, Rangaraj G, Jiang Y, Hachem RY, Raad I. Differentiating Coagulase-Negative Staphylococcal Bacteremia from Contamination Using Time to Positivity and Quantitative Blood Cultures Methods. J Clin Microbiol 47(10):3255-60, 10/2009. e-Pub 8/19/2009. PMCID: PMC2756952.
16. Raad I, Kassar R, Ghannam D, Chaftari AM, Hachem R, Jiang Y. Management of the catheter in documented catheter-related coagulase-negative staphylococcal bacteremia: remove or retain? Clin Infect Dis 49(8):1187-94, 10/15/2009. PMID: 19780661.
17. Vigil KJ, Adachi JA, Aboufaycal H, Hachem RY, Reitzel RA, Jiang Y, Tarrand JJ, Chemaly RF, Bodey GP, Rolston KV, Raad I. Multidrug-resistant Escherichia coli bacteremia in cancer patients. Am J Infect Control 37(9):741-5, 11/2009. e-Pub 5/31/2009. PMID: 19487050.
18. Chemaly RF, Rathod DB, Raad II. A tertiary care cancer center experience of the 2007 outbreak of Serratia marcescens bloodstream infection due to prefilled syringes. Infect Control Hosp Epidemiol 30(12):1237-8, 12/2009. PMID: 19888846.
19. Hachem R, Reitzel R, Borne A, Jiang Y, Tinkey P, Uthamanthil R, Chandra J, Ghannoum M, Raad I. Novel antiseptic urinary catheters for prevention of urinary tract infections: correlation of in vivo and in vitro test results. Antimicrob Agents Chemother 53(12):5145-9, 12/2009. e-Pub 10/5/2009. PMCID: PMC2786341.
20. Wen J, Zhao K, Gu T, Raad II. A green biocide enhancer for the treatment of sulfate-reducing bacteria (SRB) biofilms on carbon steel surfaces using glutaraldehyde. International Biodeterioration & Biodegradation. 63:1102-1106, 2009.
21. Engelhard D, Akova M, Boeckh MJ, Freifeld A, Sepkowitz K, Viscoli C, Wade J, Raad I. Bacterial infection prevention after hematopoietic cell transplantation. Bone Marrow Transplant 44(8):467-480, 2009.
22. Wen J, Zhao K, Gu T, Raad I. Chelators enhanced biocide inhibition of planktonic sulfate-reducing bacterial growth. World J Microbiol Biotechnol online publication, 2009.
23. Ghide S, Jiang Y, Hachem R, Chaftari AM, Raad I. Catheter-Related Corynebacterium Bacteremia: Should the Catheter Be Removed and Vancomycin Administered? Eur J Clin Microbiol Infect Dis 29(2):153-6, 2/2010. e-Pub 12/17/2009. PMID: 20016995.
24. Rangaraj G, Granwehr BP, Jiang Y, Hachem R, Raad I. Perils of quinolone exposure in cancer patients: breakthrough bacteremia with multidrug-resistant organisms. Cancer 116(4):967-973, 2/15/2010. e-Pub 1/2010. PMID: 20052728.
25. Chemaly RF, Hachem RY, Husni RN, Bahna B, Abou Rjaili G, Waked A, Graviss L, Bekele BN, Shah JN, Raad II. Erratum to: Characteristics and Outcomes of Methicillin-Resistant Staphylococcus aureus Surgical-Site Infections in Patients with Cancer: a Case-Control Study. Ann Surg Oncol. e-Pub 3/12/2010. PMID: 20224857.
26. Chemaly RF, Hachem RY, Husni RN, Bahna B, Rjaili GA, Waked A, Graviss L, Nebiyou Bekele B, Shah JN, Raad II. Characteristics and outcomes of methicillin-resistant Staphylococcus aureus surgical-site infections in patients with cancer: a case-control study. Ann Surg Oncol 17(6):1499-506, 6/2010. e-Pub 2/3/2010. PMID: 20127184.
27. Safdar A, Ma J, Saliba F, Dupont B, Wingard JR, Hachem RY, Mattiuzzi GN, Chandrasekar PH, Kontoyiannis DP, Rolston KV, Walsh TJ, Champlin RE, Raad II. Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis. Medicine (Baltimore) 89(4):236-44, 7/2010. PMID: 20616663.
28. Chemaly RF, Sharma PS, Youssef S, Gerber D, Hwu P, Hanmod SS, Jiang Y, Hachem RY, Raad II. The efficacy of catheters coated with minocycline and rifampin in the prevention of catheter-related bacteremia in cancer patients receiving high-dose interleukin-2. Int J Infect Dis 14(7):e548-52, 7/2010. e-Pub 12/14/2009. PMID: 20005762.
29. Hogan HL, Hachem RY, Neuhauser M, Raad I, Coyle E. Clinical Experience of Linezolid in Bone Marrow Transplant Patients. Journal of Pharmacy Practice 23(4):352-357, 8/2010.
30. Chaftari AM, Hachem R, Mulanovich V, Chemaly RF, Adachi J, Jacobson K, Jiang Y, Raad I. Efficacy and safety of daptomycin in the treatment of Gram-positive catheter-related bloodstream infections in cancer patients. Int J Antimicrob Agents 36(2)(2):182-186, 8/2010. e-Pub 5/8/2010. PMID: 20452752.
31. Al Wohoush I, Cairo J, Rangaraj G, Granwehr B, Hachem R, Raad I. Comparing quantitative culture of a blood sample obtained through the catheter with differential time to positivity in establishing a diagnosis of catheter-related bloodstream infection. Infect Control Hosp Epidemiol 10(10):1089-1091, 10/2010. PMID: 20807036.
32. Mihu CN, Kassis C, Ramos ER, Jiang Y, Hachem RY, Raad II. Does combination of lipid formulation of amphotericin B and echinocandins improve outcome of invasive aspergillosis in hematological malignancy patients? Cancer 116(22):5290-6, 11/15/2010. PMID: 20665889.
33. Chaftari AM, Kassis C, El Issa H, Al Wohoush I, Jiang Y, Rangaraj G, Caillouet B, Pravinkumar SE, Hachem RY, Raad II. Novel approach using antimicrobial catheters to improve the management of central line-associated bloodstream infections in cancer patients. Cancer. e-Pub 12/14/2010. PMID: 21157952.
34. Ramos ER, Reitzel R, Jiang Y, Hachem RY, Chaftari AM, Chemaly RF, Hackett B, Pravinkumar SE, Nates J, Tarrand JJ, Raad II. Clinical Effectiveness and Risk of Emerging Resistance Associated with Prolonged Use of Antibiotic-Impregnated Catheters: More than 0.5 Million Catheter Days and 7 Years of Clinical Experience. Crit Care Med 39(2):245-51, 2/2011. e-Pub 11/24/2010. PMID: 21057308.
35. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin Infect Dis 52(4):e56-93, 2/2011. PMID: 21258094.
36. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR. Executive Summary: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin Infect Dis 52(4):427-31, 2/2011. e-Pub 1/2011. PMID: 21205990.
37. Al Wohoush I, Rivera J, Cairo J, Hachem R, Raad I. Comparing Clinical and Microbiological Methods for the Diagnosis of True Bacteremia among Patients with Multiple Blood Cultures Positive for Coagulase-Negative Staphylococci. Clin Microbiol Infect 17(4):569-71, 4/2011. e-Pub 11/11/2010. PMID: 20854425.
38. Raad I, Bodey GP. Novel antimicrobial catheter lock solution: a new direction in which chelators replace heparin. Crit Care Med 39(4):875-6, 4/2011. PMID: 21613829.
39. Raad II, Mohamed JA, Reitzel RA, Jiang Y, Dvorak TL, Ghannoum MA, Hachem RY, Chaftari AM. The Prevention of Biofilm Colonization by Multidrug-Resistant Pathogens that Cause Ventilator-Associated Pneumonia with Antimicrobial-Coated Endotracheal Tubes. Biomaterials 32(11):2689-94, 4/2011. e-Pub 2/3/2011. PMID: 21295343.
40. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control 39(4 Suppl 1):S1-34, 5/2011. PMID: 21511081.
41. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee (HICPAC). Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 52(9):e162-93, 5/2011. e-Pub 4/1/2011. PMCID: PMC3106269.
42. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee (HICPAC) (Appendix 1). Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis 52(9):1087-99, 5/2011. PMCID: PMC3106267.
43. Lee LD, Hachem RY, Berkheiser M, Hackett B, Jiang Y, Raad II. Hospital environment and invasive aspergillosis in patients with hematologic malignancy. Am J Infect Control 40(3):247-9, 4/2012. e-Pub 8/17/2011. PMID: 21856045.
44. Chemaly RF, Rathod DB, Sikka MK, Hayden MK, Hutchins M, Horn T, Tarrand J, Adachi J, Nguyen K, Trenholme G, Raad I. Serratia marcescens bacteremia because of contaminated prefilled heparin and saline syringes: a multi-state report. Am J Infect Control 39(6):521-4, 8/2011. e-Pub 4/13/2011. PMID: 21492963.
45. Al Akhrass F, Hachem R, Mohamed JA, Tarrand J, Kontoyiannis DP, Chandra J, Ghannoum M, Haydoura S, Chaftari AM, Raad I. Central venous catheter-associated Nocardia bacteremia in cancer patients. Emerg Infect Dis 17(9):1651-8, 9/2011. PMID: 21888790.
46. Campo M, Hachem R, Jiang Y, Dvorak T, Carrillo-Marquez M, Hulten K, Chemaly RF, Raad I. Panton valentine Leukocidin exotoxin has no effect on the outcome of cancer patients with methicillin-resistant staphylococcus aureus (MRSA) infections. Medicine (Baltimore) 90(5):312-8, 9/2011. PMID: 21862937.
47. Cairo J, Hachem R, Rangaraj G, Granwehr B, Raad I. Predictors of catheter-related gram-negative bacilli bacteraemia among cancer patients. Clin Microbiol Infect 17(11):1711-6, 11/2011. e-Pub 5/20/2011. PMID: 21595787.
48. Ramos ER, Jiang Y, Hachem R, Kassis C, Kontoyiannis DP, Raad I. Outcome analysis of invasive aspergillosis in hematologic malignancy and hematopoietic stem cell transplant patients: the role of novel antimold azoles. Oncologist 16(7):1049-60, 2011. e-Pub 6/9/2011. PMID: 21659609.
49. Raad I, Mohamed JA, Reitzel RA, Jiang Y, Raad S, Al Shuaibi M, Chaftari AM, Hachem RY. Improved antibiotic impregnated catheters with extended spectrum activity against resistant bacteria and fungi. Antimicrob Agents Chemother 56(2):935-41, 2/2012. e-Pub 11/28/2011. PMCID: PMC3264266.
50. Aboshady I, Raad I, Shah AS, Vela D, Dvorak T, Safi HJ, Buja LM, Khalil KG. A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection. J Vasc Surg. e-Pub 5/10/2012. PMID: 22579134.
51. Shomali W, Hachem R, Chaftari AM, Jiang Y, Bahu R, Jabbour J, Raad S, Al Shuaibi M, Al Wohoush I, Raad I. Can procalcitonin distinguish infectious fever from tumor-related fever in non-neutropenic cancer patients? Cancer 118(23):5823-9, 12/1/2012. e-Pub 5/17/2012. PMID: 22605389.
52. Torres HA, Nevah MI, Barnett BJ, Mahale P, Kontoyiannis DP, Hassan MM, Raad II. Hepatitis C virus genotype distribution varies by underlying disease status among patients in the same geographic region: A retrospective multicenter study. J Clin Virol 54(3):218-22, 7/2012. e-Pub 3/28/2012. PMID: 22459004.
53. Al Akhrass F, Al Wohoush I, Chaftari AM, Reitzel R, Jiang Y, Ghannoum M, Tarrand J, Hachem R, Raad I. Rhodococcus bacteremia in cancer patients is mostly catheter related and associated with biofilm formation. PLoS One 7(3):e32945, 2012. e-Pub 3/13/2012. PMCID: PMC3302794.

Last updated: 1/7/2013