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Jack Phan, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2006 UCLA School of Medicine, Medical Scientist Training Program, Los Angeles, CA, MD, Medicine
2006 UCLA School of Medicine, Medical Scientist Training Program. Area of research: Genes involved in energy metabolism, Los Angeles, CA, PHD, Area of research: Genes involved in energy metabolism
1998 University of California, Los Angeles, CA, BS, Molecular Cell and Development Biology

Postgraduate Training

7/2007-6/2011 Clinical Fellowship, Residency, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Christopher Crane, M.D.
6/2006-7/2007 Clinical Fellowship, Internship, Surgical/Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Program Director: Mark Farnie, M.D.
6/2004-6/2006 Clinical Fellowship, Post-Doctor Fellow, University of California, Los Angeles, CA, Principal Investigator: Karen Reue, Ph.D.

Honors and Awards

2010 ARS Travel Grant
2010 M.D. Anderson "Rad Onc 2010" Ed Montague Award
2010 M.D. Anderson Trainee Research Day Poster Finalist
2006 UCLA MSTP Scholarship Day Award for Outstanding Presentation
2005 UCLA Auxiliary's Covel Scholarship Award
2003 Kern Aspen Lipid Conference Young Investigators Award
2003 WSCI, WAFMR, WAP EE Osgoode Award Winner for Outstanding Abstract
2002 UCLA Auxiliary's 2002 Kaplan Scholarship Recipient
2002 WAFMR/WSCI/WSPR Award for Metabolism-Lipid/Diabetes Research
2001 American Heart Association Medical Student Research Fellowship
2001 American Medical Association Johnson F. Hammond Memorial Scholar for Medical Journalism
2001 NSRF/UTMB Award for Biochemistry/Molecular Biology Research
2001 WAFMR/WSCI/WSPR Award for Lipid Metabolism Research
2001 WSMRF Lardinois Award for Outstanding Abstract
2000 American Heart Association Young Investigators Award

Selected Publications

Peer-Reviewed Original Research Articles
1. Phan J, Mazloom A, Abboud M, Salehpour M, Reed V, Zreik T, Shihadeh F, Fisher C, Wogan C, Dabaja B. Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy. Am J Clin Oncol 34(5):499-505, 10/2011. e-Pub 4/2011. PMID: 21537149.
2. Phan J, Mazloom A, Jeffrey Medeiros L, Zreik TG, Wogan C, Shihadeh F, Rodriguez MA, Fayad L, Fowler N, Reed V, Horace P, Dabaja BS. Benefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapy. J Clin Oncol 28(27):4170-4176, 9/2010. e-Pub 8/2010. PMID: 20713859.
3. Anderson JF, Swanson DA, Levy LB, Kuban DA, Lee AK, Kudchadker R, Phan J, Bruno T, Frank SJ. Urinary side effects and complications after permanent prostate brachytherapy: the MD Anderson Cancer Center experience. Urology 74(3):601-605, 9/2009. e-Pub 7/2009. PMID: 19589580.
4. Phan J, Swanson DA, Levy LB, Kudchadker RJ, Bruno TL, Frank SJ. Late rectal complications after prostate brachytherapy for localized prostate cancer: incidence and management. Cancer 115(9):1827-1839, 5/2009. PMID: 19248043.
5. Phan J, Hickey MA, Zhang P, Chesselet MF, Reue K. Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum Mol Genet 18(6):1006-1016, 3/2009. e-Pub 1/2009. PMCID: PMC2649017.
6. Xu J, Lee WN, Phan J, Saad MF, Reue K, Kurland IJ. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 55(12):3429-3438, 12/2006. PMID: 17130489.
7. Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ, McGehee RE, Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 55(10):2811-2818, 10/2006. PMID: 17003347.
8. Reue K, Phan J. Metabolic consequences of lipodystrophy in mouse models. Curr Opin Clin Nutr Metab Care 9(4):436-441, 7/2006. PMID: 16778573.
9. Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L. Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet 15(3):377-386, 2/2006. e-Pub 12/2005. PMID: 16357106.
10. Péterfy M, Phan J, Reue K. Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280(38):32883-9, 9/2005. e-Pub 7/2005. PMID: 16049017.
11. Phan J, Peterfy M, Reue K. Biphasic expression of lipin suggests dual roles in adipocyte development. Drug News Perspect 18(1):5-11, Jan-Feb, 1/2005. PMID: 15753971.
12. Phan J, Reue K. Lipin, a lipodystrophy and obesity gene. Cell Metab 1(1):73-83, 1/2005. PMID: 16054046.
13. Phan J, Moffitt R, Dale J, Petros J, Young A, Wang M. Improvement of SVM Algorithm for Microarray Analysis Using Intelligent Parameter Selection. Conf Proc IEEE Eng Med Biol Soc 5:4838-4841, 2005. PMID: 17281325.
14. Phan J, Péterfy M, Reue K. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J Biol Chem 279(28):29558-29564, 7/2004. e-Pub 4/2004. PMID: 15123608.
15. Vergnes L, Phan J, Strauss M, Tafuri S, Reue K. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 278(44):42774-42784, 10/2003. e-Pub 8/2003. PMID: 12923166.
16. Vergnes L, Phan J, Stolz A, Reue K. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res 44(3):503-511, 3/2003. e-Pub 12/2002. PMID: 12562828.
17. Phan J, Zdanov A, Evdokimov AG, Tropea JE, Peters HK, Kapust RB, Li M, Wlodawer A, Waugh DS. Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem 277(52):50564-50572, 12/2002. e-Pub 10/2002. PMID: 12377789.
18. Phan J, Pesaran T, Davis RC, Reue K. The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem 277(1):469-477, 1/2002. e-Pub 10/2001. PMID: 11682476.
19. Péterfy M, Phan J, Xu P, Reue K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27(1):121-124, 1/2001. PMID: 11138012.
20. Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L. Catalytic cysteine of thymidylate synthase is activated upon substrate binding. Biochemistry 39(23):6969-6978, 6/2000. PMID: 10841779.
21. Mouzeyan A, Choi J, Allayee H, Wang X, Sinsheimer J, Phan J, Castellani LW, Reue K, Lusis AJ, Davis RC. A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res 41(4):573-582, 4/2000. PMID: 10744778.
22. Phan J, Reue K, Péterfy M. MS-IRS PCR: a simple method for the isolation of microsatellites. Biotechniques 28(1):18-20, 1/2000. PMID: 10649761.

Book Chapters
1. Vergnes L, Phan J, Reue K. In: Unraveling Lipid Metabolism with Microarrays: New York, 66-125, 2004.

Last updated: 2/15/2013