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Jack Phan, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2006 UCLA School of Medicine, Medical Scientist Training Program, Los Angeles, CA, MD, Medicine
2006 UCLA School of Medicine, Medical Scientist Training Program, Los Angeles, CA, PHD, Area of research: Genes involved in energy metabolism
1998 University of California, Los Angeles (UCLA), Los Angeles, CA, BS, Molecular Cell and Development Biology

Postgraduate Training

7/2007-6/2011 Clinical Fellowship, Residency, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Christopher Crane, M.D.
6/2006-7/2007 Clinical Fellowship, Internship, Surgical/Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Program Director: Mark Farnie, M.D.
6/2004-6/2006 Clinical Fellowship, Post-Doctor Fellow, University of California, Los Angeles (UCLA), Los Angeles, CA, Principal Investigator: Karen Reue, Ph.D.

Board Certifications

6/2013 American Board of Radiology

Honors and Awards

2010 ARS Travel Grant
2010 M.D. Anderson "Rad Onc 2010" Ed Montague Award
2010 M.D. Anderson Trainee Research Day Poster Finalist
2006 UCLA MSTP Scholarship Day Award for Outstanding Presentation
2005 UCLA Auxiliary's Covel Scholarship Award
2003 Kern Aspen Lipid Conference Young Investigators Award
2003 WSCI, WAFMR, WAP EE Osgoode Award Winner for Outstanding Abstract
2002 UCLA Auxiliary's 2002 Kaplan Scholarship Recipient
2002 WAFMR/WSCI/WSPR Award for Metabolism-Lipid/Diabetes Research
2001 American Heart Association Medical Student Research Fellowship
2001 American Medical Association Johnson F. Hammond Memorial Scholar for Medical Journalism
2001 NSRF/UTMB Award for Biochemistry/Molecular Biology Research
2001 WAFMR/WSCI/WSPR Award for Lipid Metabolism Research
2001 WSMRF Lardinois Award for Outstanding Abstract
2000 American Heart Association Young Investigators Award

Selected Publications

Peer-Reviewed Original Research Articles

1. Sio TT, Lin HK, Shi Q, Gunn GB, Cleeland CS, Lee JJ, Hernandez M, Blanchard P, Thaker NG, Phan J, Rosenthal DI, Garden AS, Morrison WH, Fuller CD, Mendoza TR, Mohan R, Wang XS, Frank SJ. Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes. Int J Radiat Oncol Biol Phys 95(4):1107-14, 7/2016. e-Pub 2/2016. PMID: 27354125.
2. Reddy GD, Wagner K, Phan J, DeMonte F, Raza SM. Management of Skull Base Tumor-Associated Facial Pain. Neurosurg Clin N Am 27(3):337-44, 7/2016. PMID: 27325000.
3. Takiar V, Garden AS, Ma D, Morrison WH, Edson M, Zafereo ME, Gunn GB, Fuller CD, Beadle B, Frank SJ, William WN, Kies M, El-Naggar AK, Weber R, Rosenthal DI, Phan J. Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys 95(4):1117-31, 7/2016. e-Pub 3/2016. PMID: 27354127.
4. Grossberg AJ, Chamchod S, Fuller CD, Mohamed AS, Heukelom J, Eichelberger H, Kantor ME, Hutcheson KA, Gunn GB, Garden AS, Frank S, Phan J, Beadle B, Skinner HD, Morrison WH, Rosenthal DI. Association of Body Composition With Survival and Locoregional Control of Radiotherapy-Treated Head and Neck Squamous Cell Carcinoma. JAMA Oncol 2(6):782-9, 6/2016. e-Pub 2/2016. PMID: 26891703.
5. Garden AS, Fuller CD, Rosenthal DI, William WN, Gunn GB, Beadle BM, Johnson FM, Morrison WH, Phan J, Frank SJ, Kies MS, Sturgis EM. Radiation therapy (with or without neck surgery) for phenotypic human papillomavirus-associated oropharyngeal cancer. Cancer 122(11):1702-7, 6/2016. e-Pub 3/2016. PMCID: PMC4873387.
6. Holliday EB, Esmaeli B, Pinckard J, Garden AS, Rosenthal DI, Morrison WH, Kies MS, Gunn GB, Fuller CD, Phan J, Beadle BM, Zhu XR, Zhang X, Frank SJ. A Multidisciplinary Orbit-Sparing Treatment Approach That Includes Proton Therapy for Epithelial Tumors of the Orbit and Ocular Adnexa. Int J Radiat Oncol Biol Phys 95(1):344-52, 5/2016. e-Pub 8/2015. PMID: 26454680.
7. Gunn GB, Blanchard P, Garden AS, Zhu XR, Fuller CD, Mohamed AS, Morrison WH, Phan J, Beadle BM, Skinner HD, Sturgis EM, Kies MS, Hutcheson KA, Rosenthal DI, Mohan R, Gillin MT, Frank SJ. Clinical Outcomes and Patterns of Disease Recurrence After Intensity Modulated Proton Therapy for Oropharyngeal Squamous Carcinoma. Int J Radiat Oncol Biol Phys 95(1):360-7, 5/2016. e-Pub 2/2016. PMID: 27084653.
8. Nien HH, Sturgis EM, Kies MS, El-Naggar AK, Morrison WH, Beadle BM, Johnson FM, Gunn GB, Fuller CD, Phan J, Gold KA, Frank SJ, Skinner H, Rosenthal DI, Garden AS. Comparison of systemic therapies used concurrently with radiation for the treatment of human papillomavirus-associated oropharyngeal cancer. Head Neck 38 Suppl 1:E1554-61, 4/2016. e-Pub 11/2015. PMID: 26595157.
9. Bishop AJ, Garden AS, Gunn GB, Rosenthal DI, Beadle BM, Fuller CD, Levy LB, Gillenwater AM, Kies MS, Esmaeli B, Frank SJ, Phan J, Morrison WH. Merkel cell carcinoma of the head and neck: Favorable outcomes with radiotherapy. Head Neck 38 Suppl 1:E452-8, 4/2016. e-Pub 7/2015. PMID: 25645649.
10. Jiang W, Chamberlain PD, Garden AS, Kim BY, Ma D, Lo EJ, Bell D, Gunn GB, Fuller CD, Rosenthal DI, Beadle BM, Frank SJ, Morrison WH, El-Naggar AK, Glisson BS, Sturgis EM, Phan J. Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas. Head Neck 38 Suppl 1:E1459-66, 4/2016. e-Pub 11/2015. PMID: 26560893.
11. Phan J, Sio TT, Nguyen TP, Takiar V, Gunn GB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Beadle B, Ma D, Zafereo ME, Hutcheson KA, Kupferman ME, William WN, Frank SJ. Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys. e-Pub 4/2016. PMID: 27325480.
12. Shoultz-Henley S, Garden AS, Mohamed AS, Sheu T, Kroll MH, Rosenthal DI, Gunn GB, Hayes AJ, French C, Eichelberger H, Kalpathy-Cramer J, Smith BD, Phan J, Ayoub Z, Lai SY, Pham B, Kies M, Gold KA, Sturgis E, Fuller CD. Prognostic value of pretherapy platelet elevation in oropharyngeal cancer patients treated with chemoradiation. Int J Cancer 138(5):1290-7, 3/2016. e-Pub 10/2015. PMCID: PMC4779600.
13. Messer JA, Mohamed AS, Hutcheson KA, Ding Y, Lewin JS, Wang J, Lai SY, Frank SJ, Garden AS, Sandulache V, Eichelberger H, French CC, Colen RR, Phan J, Kalpathy-Cramer J, Hazle JD, Rosenthal DI, Gunn GB, Fuller CD. Magnetic resonance imaging of swallowing-related structures in nasopharyngeal carcinoma patients receiving IMRT: Longitudinal dose-response characterization of quantitative signal kinetics. Radiother Oncol 118(2):315-22, 2/2016. e-Pub 1/2016. PMCID: PMC4794348.
14. Wang H, Wang C, Tung S, Dimmitt AW, Wong PF, Edson MA, Garden AS, Rosenthal DI, Fuller CD, Gunn GB, Takiar V, Wang XA, Luo D, Yang JN, Wong J, Phan J. Improved setup and positioning accuracy using a three-point customized cushion/mask/bite-block immobilization system for stereotactic reirradiation of head and neck cancer. J Appl Clin Med Phys 17(3):6038, 2016. e-Pub 5/2016. PMID: 27167275.
15. Grossberg A, Zhao Z, Walker G, Tsai J, Wang X, Lang F, Phan J, Ghia A, McGovern S, Mahajan A, Brown P, McAleer MF, Li J. Dose painting with Gamma Knife: Two techniques for delivering different doses to areas of recurrent or residual tumor after resection of brain metastases. Pract Radiat Oncol 5(6):390-7, Nov-Dec, 11/2015. e-Pub 8/2015. PMID: 26412338.
16. Gunn GB, Hansen CC, Garden AS, Fuller CD, Mohamed AS, Morrison WH, Frank SJ, Beadle BM, Phan J, Chronowski GM, Sturgis EM, Lewis CM, Lu C, Hutcheson KA, Mendoza TR, Cleeland CS, Rosenthal DI. Favorable patient reported outcomes following IMRT for early carcinomas of the tonsillar fossa: Results from a symptom assessment study. Radiother Oncol 117(1):132-8, 10/2015. e-Pub 9/2015. PMCID: PMC4762263.
17. Frank S, Garden A, Anderson M, Rosenthal D, Morrison W, Gunn B, Fuller C, Phan J, Zhang X, Poenisch F, Wu R, Li H, Gautam A, Sahoo N, Gillin M, Zhu X. SU-E-T-529: Is MFO-IMPT Robust Enough for the Treatment of Head and Neck Tumors? A 2-Year Outcome Analysis Following Proton Therapy On the First 50 Oropharynx Patients at the MD Anderson Cancer Center. Med Phys 42(6):3457, 6/2015. PMID: 26128194.
18. Tang C, Fuller CD, Garden AS, Awan MJ, Colen RR, Morrison WH, Frank SJ, Beadle BM, Phan J, Sturgis EM, Zafereo ME, Weber RS, Rosenthal DI, Gunn GB. Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response. Oral Oncol 51(2):195-201, 2/2015. e-Pub 11/2014. PMCID: PMC4502963.
19. Garden AS, Gunn GB, Hessel A, Beadle BM, Ahmed S, El-Naggar AK, Fuller CD, Byers LA, Phan J, Frank SJ, Morrison WH, Kies MS, Rosenthal DI, Sturgis EM. Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer. Cancer 120(19):3082-8, 10/2014. e-Pub 6/2014. PMCID: PMC4172550.
20. Sheu T, Fuller CD, Mendoza TR, Garden AS, Morrison WH, Beadle BM, Phan J, Frank SJ, Hanna EY, Lu C, Cleeland CS, Rosenthal DI, Gunn GB. Nomogram for Predicting Symptom Severity during Radiation Therapy for Head and Neck Cancer. Otolaryngol Head Neck Surg 151(4):619-26, 10/2014. e-Pub 8/2014. PMCID: PMC4184965.
21. Walker GV, Awan M, Tao R, Koay EJ, Boehling NS, Grant JD, Sittig DF, Gunn GB, Garden AS, Phan J, Morrison WH, Rosenthal DI, Mohamed AS, Fuller CD. Prospective randomized double-blind study of atlas-based organ-at-risk autosegmentation-assisted radiation planning in head and neck cancer. Radiother Oncol 112(3):321-5, 9/2014. e-Pub 9/2014. PMCID: PMC4252740.
22. Kocak-Uzel E, Gunn GB, Colen RR, Kantor ME, Mohamed AS, Schoultz-Henley S, Mavroidis P, Frank SJ, Garden AS, Beadle BM, Morrison WH, Phan J, Rosenthal DI, Fuller CD. Beam path toxicity in candidate organs-at-risk: Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy. Radiother Oncol 111(2):281-8, 5/2014. e-Pub 4/2014. PMCID: PMC4063998.
23. Gunn GB, Debnam JM, Fuller CD, Morrison WH, Frank SJ, Beadle BM, Sturgis EM, Glisson BS, Phan J, Rosenthal DI, Garden AS. The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Cancer 119(17):3162-9, 9/2013. e-Pub 6/2013. PMCID: PMC3775996.
24. Awan M, Kalpathy-Cramer J, Gunn GB, Beadle BM, Garden AS, Phan J, Holliday E, Jones WE, Maani E, Patel A, Choi J, Clyburn V, Tantiwongkosi B, Rosenthal DI, Fuller CD. Prospective assessment of an atlas-based intervention combined with real-time software feedback in contouring lymph node levels and organs-at-risk in the head and neck: Quantitative assessment of conformance to expert delineation. Pract Radiat Oncol 3(3):186-93, Jul-Sep, 7/2013. e-Pub 12/2012. PMCID: PMC3706296.
25. Awan M, Kalpathy-Cramer J, Gunn GB, Beadle BM, Garden AS, Phan J, Holliday E, Jones WE, Maani E, Patel A, Choi J, Clyburn V, Tantiwongkosi B, Rosenthal DI, Fuller CD. Prospective Assessment of an Atlas-Based Intervention Combined With Real-Time Software Feedback in Contouring Lymph Node Levels and Organs-at-Risk in the Head and Neck: Quantitative Assessment of Conformance to Expert Delineation. Pract Radiat Oncol 3(3):186193, 7/2013. PMCID: PMC3706296.
26. Sharp HJ, Swanson DA, Pugh TJ, Zhang M, Phan J, Kudchadker R, Bruno TL, Kuban DA, Lee AK, Choi S, Nguyen QN, Hoffman KE, McGuire SE, Frank SJ. Screening colonoscopy before prostate cancer treatment can detect colorectal cancers in asymptomatic patients and reduce the rate of complications after brachytherapy. Pract Radiat Oncol 2(3):e7-e13, Jul-Sep, 7/2012. e-Pub 1/2012. PMID: 24674130.
27. Phan J, Mazloom A, Abboud M, Salehpour M, Reed V, Zreik T, Shihadeh F, Fisher C, Wogan C, Dabaja B. Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy. Am J Clin Oncol 34(5):499-505, 10/2011. e-Pub 4/2011. PMID: 21537149.
28. Phan J, Mazloom A, Medeiros LJ, Zreik TG, Wogan C, Shihadeh F, Rodriguez MA, Fayad L, Fowler N, Reed V, Horace P, Dabaja BS. Benefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapy. J Clin Oncol 28(27):4170-4176, 9/2010. e-Pub 8/2010. PMID: 20713859.
29. Anderson JF, Swanson DA, Levy LB, Kuban DA, Lee AK, Kudchadker R, Phan J, Bruno T, Frank SJ. Urinary side effects and complications after permanent prostate brachytherapy: the MD Anderson Cancer Center experience. Urology 74(3):601-605, 9/2009. e-Pub 7/2009. PMID: 19589580.
30. Phan J, Swanson DA, Levy LB, Kudchadker RJ, Bruno TL, Frank SJ. Late rectal complications after prostate brachytherapy for localized prostate cancer: incidence and management. Cancer 115(9):1827-1839, 5/2009. PMID: 19248043.
31. Phan J, Hickey MA, Zhang P, Chesselet MF, Reue K. Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum Mol Genet 18(6):1006-1016, 3/2009. e-Pub 1/2009. PMCID: PMC2649017.
32. Xu J, Lee WN, Phan J, Saad MF, Reue K, Kurland IJ. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 55(12):3429-3438, 12/2006. PMID: 17130489.
33. Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ, McGehee RE, Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 55(10):2811-2818, 10/2006. PMID: 17003347.
34. Reue K, Phan J. Metabolic consequences of lipodystrophy in mouse models. Curr Opin Clin Nutr Metab Care 9(4):436-441, 7/2006. PMID: 16778573.
35. Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L. Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet 15(3):377-386, 2/2006. e-Pub 12/2005. PMID: 16357106.
36. Péterfy M, Phan J, Reue K. Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280(38):32883-9, 9/2005. e-Pub 7/2005. PMID: 16049017.
37. Phan J, Peterfy M, Reue K. Biphasic expression of lipin suggests dual roles in adipocyte development. Drug News Perspect 18(1):5-11, Jan-Feb, 1/2005. PMID: 15753971.
38. Phan J, Reue K. Lipin, a lipodystrophy and obesity gene. Cell Metab 1(1):73-83, 1/2005. PMID: 16054046.
39. Phan J, Moffitt R, Dale J, Petros J, Young A, Wang M. Improvement of SVM Algorithm for Microarray Analysis Using Intelligent Parameter Selection. Conf Proc IEEE Eng Med Biol Soc 5:4838-4841, 2005. PMID: 17281325.
40. Phan J, Péterfy M, Reue K. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J Biol Chem 279(28):29558-29564, 7/2004. e-Pub 4/2004. PMID: 15123608.
41. Vergnes L, Phan J, Strauss M, Tafuri S, Reue K. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 278(44):42774-42784, 10/2003. e-Pub 8/2003. PMID: 12923166.
42. Vergnes L, Phan J, Stolz A, Reue K. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res 44(3):503-511, 3/2003. e-Pub 12/2002. PMID: 12562828.
43. Phan J, Zdanov A, Evdokimov AG, Tropea JE, Peters HK, Kapust RB, Li M, Wlodawer A, Waugh DS. Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem 277(52):50564-50572, 12/2002. e-Pub 10/2002. PMID: 12377789.
44. Phan J, Pesaran T, Davis RC, Reue K. The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem 277(1):469-477, 1/2002. e-Pub 10/2001. PMID: 11682476.
45. Péterfy M, Phan J, Xu P, Reue K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27(1):121-124, 1/2001. PMID: 11138012.
46. Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L. Catalytic cysteine of thymidylate synthase is activated upon substrate binding. Biochemistry 39(23):6969-6978, 6/2000. PMID: 10841779.
47. Mouzeyan A, Choi J, Allayee H, Wang X, Sinsheimer J, Phan J, Castellani LW, Reue K, Lusis AJ, Davis RC. A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res 41(4):573-582, 4/2000. PMID: 10744778.
48. Phan J, Reue K, Péterfy M. MS-IRS PCR: a simple method for the isolation of microsatellites. Biotechniques 28(1):18-20, 1/2000. PMID: 10649761.

Book Chapters

1. Phan J, Garden AS. Prinicples of Radiation Oncology. In: Sataloff's Comprehensive Text of Otolaryngology. JP Brothers Medical Publishers: Philadelphia. In Press.
2. Vergnes L, Phan J, Reue K. In: Unraveling Lipid Metabolism with Microarrays, 1st. Marcel Dekker: New York, 66-125, 2004.

Grant & Contract Support

Title: Mechanical Drugs: Harnessing Cancer Aggressiveness to Overcome Its Resistance
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mien-Chie Hung, PhD
Duration: 9/1/2015 - 8/31/2020
Title: Prospective Observational Study Using Advanced Modern Conformal Radiotherapy for Reirradiation of Head & Neck Cancer to Collect Preliminary Data for Development of Clinical Stereotactic Radiation Phase I/II trial
Funding Source: MD Anderson Cancer Center
Role: Principal Investigator
Duration: 4/1/2015 - 3/31/2016

Last updated: 7/14/2016