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Jack A. Roth, M.D., F.A.C.S.

Department of Thoracic and Cardiovascular Surgery, Division of Surgery

About Dr. Jack A. Roth

Dr. Jack A. Roth earned his medical degree at Johns Hopkins University School of Medicine in 1971, and then completed postgraduate training in thoracic surgery and research at the UCLA School of Medicine. He was a senior investigator and head of the Thoracic Oncology Section in the National Cancer Institute’s Surgery Branch before joining the University of Texas M. D. Anderson Cancer Center(UTMDACC) in 1986 as professor and chair of the Department of Thoracic and Cardiovascular Surgery. He serves as founding director of the W. M. Keck Center for Innovative Cancer Therapies and holds academic appointments in UTMDACC’s Department of Molecular and Cellular Oncology and the Department of Cardiothoracic and Vascular Surgery at The University of Texas Medical School at Houston. While at the NCI, Dr. Roth completed the first randomized clinical trials of neoadjuvant chemotherapy for squamous carcinoma of the esophagus and open lung biopsy in immunocompromised patients with diffuse pulmonary infiltrates. At UTMDACC, Dr. Roth has initiated and acted as the principal investigator of the first gene therapy trials for lung cancer. Dr. Roth has spearheaded the development of institutional multidisciplinary protocols in thoracic oncology and was the principal investigator of the first randomized trial showing survival benefit with neoadjuvant chemotherapy in stage IIIA resectable lung cancer.

Primary Appointment

Professor, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Chief, Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Bud S. Johnson Distinguished Clinical Chair Emeritus, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Cardiothoracic and Vascular Surgery, The University of Texas Medical School at Houston, Houston, TX

Research Interests

Among his landmark achievements, Dr. Roth was principal investigator for the first tumor suppressor gene therapy clinical trials approved by the National Institutes of Health Recombinant DNA Advisory Committee and the U.S. Food and Drug Administration. Approval for those historic protocols was based on his demonstrating feasibility and efficacy through laboratory and preclinical studies. His team showed that restoration of function for a single normal tumor suppressor gene could mediate regression of human cancers in vivo, helped identify and characterize a number of novel tumor suppressor genes on chromosome 3, and found that systemic delivery of tumor suppressor genes using a nanoparticle vector could effectively treat disseminated human lung cancer in animal models. These observations led Dr. Roth and colleagues to initiate the first clinical trial using nanoparticles to deliver genes systemically. Cancer gene therapy developed in his laboratory became the first gene therapy to be approved for human use. In addition to being an international leader in developing gene therapy for lung and other cancers, he has trained a new generation of outstanding surgical oncologists and laboratory researchers who are applying his philosophy of excellence throughout the world.

Numerous major grants supporting the Roth-directed translational research include an NCI SPORE Grant in lung cancer, the first awarded to a UTMDACC investigator that is shared by faculty at UTMDACC and The University of Texas Southwestern Medical Center. The joint collaboration has been renewed four times. Roth was responsible for establishing the Keck Center for Innovative Cancer Therapies to serve as an institute without walls to coordinate targeted therapy studies among UTMDACC investigators. He has contributed to more than 480 articles in peer-reviewed journals and 110 book chapters, and been awarded nearly 50 U.S. and foreign patents with another 50 pending. He has received numerous awards including the Lucy Wortham James Basic Research Award, Society of Surgical Oncology; The Best Doctors in America Award for over 18 consecutive years; Award of Excellence, 32 nd Annual Congress, Japan Society for Cancer Therapy; the Charles Moetel Lecture, Mayo Clinic; the Gordon Hamilton-Farley lecture, British Association for Cancer Research and British Society for Surgical Oncology; Elaine & Gerald Schuster Distinguished Visiting Lecturer, Harvard Medical School; Inaugural Glick Lecturer, Johns Hopkins School of Medicine; the Claggett Award Lecture, Mayo Clinic; Fellow American Association for the Advancement of Science, and The Otis W. and Pearl L. Walters Faculty Achievement Award in Clinical Research.

Clinical Interests

gene therapy, lung cancer, esophageal cancer

Education & Training

Degree-Granting Education

1971	Johns Hopkins University School of Medicine, Baltimore, MD, USA, MD, Medicine
1967	Cornell University, Ithaca, NY, USA, BA, Economics

Postgraduate Training

1979-1980	Chief Resident, Division of General Surgery, UCLA School of Medicine, Los Angeles, CA
1978-1979	Chief Resident, Division of Thoracic Surgery, UCLA School of Medicine, Los Angeles, CA
1977-1978	Clinical Residency, Division of Thoracic Surgery, UCLA School of Medicine, Los Angeles, CA
1975-1977	Clinical Residency, General Surgery, UCLA School of Medicine, Los Angeles, CA
1973-1975	Research Fellowship, Division of Surgical Oncology, UCLA Center for the Health Sciences, Los Angeles, CA
1972-1973	Clinical Residency, Surgery, Johns Hopkins Hospital, Baltimore, MD
1971-1972	Clinical Internship, Surgery, Johns Hopkins Hospital, Baltimore, MD

Board Certifications

1983	American Board of Thoracic Surgery
1981	American Board of Surgery

Experience & Service

Academic Appointments

Clinical Assistant Professor, Department of Surgery, Division of School of Medicine, The Medical Center, Georgetown University, Washington, 1982 - 1986

Lecturer in Surgery, Department of Surgery, Division of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 1980 - 1986

Senior Investigator, Department of Surgery Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD, 1980 - 1986

Administrative Appointments/Responsibilities

Director, W. M. Keck Center for Innovative Cancer Therapies, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 1998 - Present

Committee Member, Coming Together to Conquer Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, 1997 - 1998

Department Chair, Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1986 - 2007

Head, Department of Thoracic Oncology Section, National Institutes of Health, National Cancer Institute, Bethesda, MD, 1982 - 1986

Other Appointments/Responsibilities

Member, Data Monitoring Committee (DMC) VA Cooperative Study, CSP #2005, “Veterans Affairs Lung Cancer Surgery or Stereotactic Radiotherapy (VALOR), Houston, TX, 2016 - Present

Co-Leader Lung Cancer Moon Shot, Office of Strategic Initiatives, The University of Texas MD Anderson, Houston, TX, 2012 - Present

Institutional Committee Activities

Co-Leader, Cancer Center Support Grant (CCSG): Lung Cancer Program, 1998 - 2019

Military or Other Governmental Service

Captain, United States Army Reserves, Medical Corps, 1971 - 1978

Honors & Awards

2019	SPORE Leadership Award, National Cancer Institute
2019	President’s Faculty Excellence Award in Research, UT MD Anderson Cancer Center
2015	Honorary Member, American Society for Radiation Oncology (ASTRO)
2015	Top Cancer Doctor, Newsweek / Castle Connolly
2015	Top Cancer Doctor, Newsweek (in conjunction with Castle Connolly)
2014	Best Doctors, U.S. News & World Report
2013	Southeastern Texas' Top Doctors, American Registry, LLC
2011	Award for High Scoring Paper at 2011 Annual Meeting, American Association for Cancer Research
2011	Best Doctors, U.S. News & World Report
2008	America's Top Surgeons
2008	The Otis W. and Pearl L. Walters Faculty Achievement Award in Clinical Research, The University of Texas M. D. Anderson Cancer Center
2008	Elkin Distinguished Investigators Cancer Lectureship, Emory University School of Medicine Winship Cancer Institute, Atlanta, GA
2007	Best Doctors, U.S. News & World Report
2007	Fellow, American Association for the Advancement of Science
2007	O. T. Clagett Visiting Professorship, Mayo Clinic. Rochester, MN
2006	SPAR Award, Top 1% of cited authors for journals in Biology and Biochemistry
2006	USPTO Records - "Top Patenters" in the life sciences, above the 99th percentile of the patent count distribution
2006	Recognized by peers as one of the top clinicians in the Houston area
2006	The Surgery Chief Resident Teaching Award, The University of Texas - Houston Medical School, Department of Surgery
2005	America's Top Doctors for Cancer, Castle Connolly Medical Ltd
2005	America's Top Doctors, Castle Connolly
2004	Inaugural Glick Lecturer, Johns Hopkins School of Medicine
2003	Best Doctors 10 Year Veteran
2002	The Surgery Chief Resident Teaching Award, The University of Texas - Houston Medical School, Department of Surgery
2001	Best Doctors, U.S. News & World Report
2000	Elaine & Gerald Schuster Distinguished Visiting Lecturer, Boston, MA, Dana-Farber Cancer Institute, Harvard Medical School
1998	Top 20 Texans, Texas Monthly Magazine
1997	Gordon Hamilton-Fairley Lecture Award, British Association for Cancer Research and British Society for Surgical Oncology
1997	Charles Moetel Lectureship, Mayo Clinic
1996	Inaugural Wittcoff Lecturer, Mayo Clinic
1996	Jack Sadler Memorial Lectureship, University of Colorado Health Sciences Center
1995	Charles L. Roper Visiting Professor, Washington University School of Medicine
1995	Victor and Sigried Gilbertson Visiting Lecturer, University of MN, School of Medicine
1995	Elected Corresponding Member , European Society of Thoracic Surgeons
1994	Ernest Bruell Lectureship, Cleveland Clinic Foundation
1994	The Award of Excellence for a Special Lecture, The 32nd Annual Congress of Japan Society for Cancer Therapy
1994	E.J. Tabah Visiting Professor in Surgical Oncology, Royal Victoria Hospital and McGill
1993	W.B. Cosbie Lecture , The Royal College of Physicians and Surgeons of Canada
1992	First Invited Scientific Plenary Lecturer, Radiation Therapy Oncology Group
1992	Lucy Wortham James Basic Research Award , Society of Surgical Oncology
1991	Distinguished Lecturer, University of Medicine and Dentistry of New Jersey
1991	The Best Doctors in America
1990	One of 400 Best Doctors in America
1985	Merit Award, Grant R01 CA45187, Division of Research Grants and Biologic Response, Modifiers Program, National Institutes of Health
1984	Fellow, American College of Surgeons
1981	Special Achievement Award: Characterization of an immunoregulatory factor in extracts of lung carcinoma, U.S. Department of Health and Human Services
1980	Mead Johnson Excellence of Research Award, National Research Forum
1977	Society of Surgical Oncology Resident/Fellow Award: Effect of Adriamycin and High-Dose Methotrexate Chemotherapy on In vivo and In vitro Cell-Mediated Immunity in Cancer Patients
1973	Resident-Fellow Clinical Research Award paper: Isolation of Soluble Tumor-associated Antigen From Human Melanoma, James Ewing Society (Society of Surgical Oncology)
1971	Outstanding Student Research Presentation, Johns Hopkins Medical Society
1967	Phi Beta Kappa, Cornell University
1967	B.A. Magna Cum Laude with distinction in all subjects, Cornell University

Professional Memberships

American Society for Radiation Oncology (ASTRO)

Honorary Member, 2015 - Present

VA Lung Study Surgical Advisory Committee, Houston, TX

Member, 2014 - Present

American Association for Thoracic Surgery

Member, Graham Foundation, 2012 - Present

Society for Leukocyte Biology, Bethesda, MD

Member, 2012 - Present

Lung Cancer Research Foundation Medical Advisory Board, New York, NY

Member, 2011 - Present

Radiation Safety Committee (RSC), Houston, TX

Member, 2011 - Present

American Association of Academic Surgeons

Fellow, 2007 - Present

American Association for Thoracic Surgery, Beverly, MA

Subcommittee Chair, Scientific Affairs and Government Relations Committee, 2004 - Present

The Thoracic Surgery Foundation

Member, Research Committee, 2004 - Present

International Association for the Study of Lung Cancer

Member, 2004 - Present

Texas Faculty Association

Member, 2002 - Present

American Society of Gene and Cell Therapy, Greenwich, CT

Member, 1999 - Present

South Texas Chapter of the American College of Surgeons, Metairie, LA

Member, 1999 - Present

American College of Chest Physicians

Member, 1992 - Present

Surgical Biology Club II, Portland, OR

Member, 1989 - Present

American Surgical Association, MA

Member, Thoracic, 1989 - Present

General Thoracic Surgery Club, Rochester, MN

Member, 1988 - Present

Houston Surgical Society, TX

Member, 1988 - Present

Harris County Medical Society, TX

Member, 1987 - Present

Texas Medical Association

Member, 1987 - Present

Society of Thoracic Surgeons

Senior Member, 1984 - Present

Society of University Surgeons

Life Member, 1984 - Present

Longmire Surgical Society, Los Angeles, CO

Member, 1980 - Present

Selected Publications

Peer-Reviewed Articles

Rice D, Rodriguez-Restrepo A, Mena G, Cata J, Thall P, Milton D, Correa A, Woodard T, Antonoff M, Hofstetter W, Roth J, Sepesi B, Swisher S, Walsh G, Vaporciyan A, Mehran R. Matched Pairs Comparison of an Enhanced Recovery Pathway Versus Conventional Management on Opioid Exposure and Pain Control in Patients Undergoing Lung Surgery. Ann Surg 274(6):1099-1106, 2021. e-Pub 2020. PMID: 32229762.
Mitchell KG, Parra ER, Zhang J, Nelson DB, Corsini EM, Villalobos P, Moran CA, Skoulidis F, Wistuba II, Fujimoto J, Roth JA, Antonoff MB, MD Anderson Lung Cancer Immune Microenvironment Working Group. LKB1/STK11 Expression in Lung Adenocarcinoma and Associations with Patterns of Recurrence. Ann Thorac Surg 110(4):1131-1138, 2020. e-Pub 2020. PMID: 32442617.
Shewale JB, Corsini EM, Correa AM, Brown EL, Leon-Novelo LG, Nyitray AG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth J, Walsh GL, Vaporciyan AA, Swisher SG, Sepesi B. Time trends and predictors of survival in surgically resected early-stage non-small cell lung cancer patients. J Surg Oncol 122(3):495-505, 2020. e-Pub 2020. PMID: 32356321.
Hong L, Negrao MV, Dibaj SS, Chen R, Reuben A, Bohac JM, Liu X, Skoulidis F, Gay CM, Cascone T, Mitchell KG, Tran HT, Le X, Byers LA, Sepesi B, Altan M, Elamin YY, Fossella FV, Kurie JM, Lu C, Mott FE, Tsao AS, Rinsurongkawong W, Lewis J, Gibbons DL, Glisson BS, Blumenschein GR, Roarty EB, Futreal PA, Wistuba II, Roth JA, Swisher SG, Papadimitrakopoulou VA, Heymach JV, Lee JJ, Simon GR, Zhang J. Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in NSCLC. J Thorac Oncol 15(9):1449-1459, 2020. e-Pub 2020. PMID: 32389639.
Corsini EM, Mitchell KG, Hofstetter WL, Mehran RJ, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB, Rice DC. Importance of resection for locoregional disease control in Masaoka stage IVA thymic neoplasms. J Surg Oncol 122(3):515-522, 2020. e-Pub 2020. PMID: 32468580.
Rajaram R, Correa AM, Xu T, Nguyen QN, Antonoff MB, Rice D, Mehran R, Roth J, Walsh G, Swisher S, Hofstetter WL, Vaporciyan A, Cascone T, Tsao AS, Papadimitrakopoulou VA, Gandhi S, Liao Z, Sepesi B. Locoregional Control, Overall Survival, and Disease-Free Survival in Stage IIIA (N2) Non-Small-Cell Lung Cancer: Analysis of Resected and Unresected Patients. Clin Lung Cancer 21(4):e294-e301, 2020. e-Pub 2020. PMID: 32089476.
Weissferdt A, Pataer A, Vaporciyan AA, Correa AM, Sepesi B, Moran CA, Wistuba II, Roth JA, Shewale JB, Heymach JV, Kalhor N, Cascone T, Hofstetter WL, Lee JJ, Swisher SG. Agreement on Major Pathological Response in NSCLC Patients Receiving Neoadjuvant Chemotherapy. Clin Lung Cancer 21(4):341-348, 2020. e-Pub 2020. PMID: 32279936.
Corsini EM, Datar SS, Mitchell KG, Zhou N, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Blackmon SH, Loree JM, Morris VK, Antonoff MB. High Mutational Concordance Between Primary Colorectal Tumors and Associated Pulmonary Metastases. J Surg Oncol 121(6):984-989, 2020. e-Pub 2020. PMID: 32077113.
Mitchell KG, Nelson DB, Corsini EM, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Sepesi B, Walsh GL, Bhutani MS, Maru DM, Wu CC, Nguyen QN, Ajani JA, Swisher SG, Hofstetter WL. Morbidity following Salvage Esophagectomy for Squamous Cell Carcinoma: The MD Anderson Experience. Dis Esophagus 33(3), 2020. e-Pub 2019. PMID: 31313820.
Evrard YA, Srivastava A, Randjelovic J, Consortium NP (Roth JA), Doroshow JH, Dean DA, Morris JS, Chuang JH. Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis. Cancer Res. e-Pub 2020. PMID: 32152150.
Stewart CA, Gay CM, Xi Y, Sivajothi S, Sivakamasundari V, Fujimoto J, Bolisetty M, Hartsfiled PM, Balasubramaniyan V, Chalishazar MD, Moran C, Kalhor N, Stewart J, Tran H, Swisher SG, Roth JA, Zhang J, de Groot J, Glisson B, Oliver TG, Heymach JV, Wistuba I, Robson P, Wang J, Byers LA. Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer. Nat Cancer, 2020.
Gainor JF, Rizvi H, Jimenez Aguilar E, Skoulidis F, Yeap BY, Naidoo J, Khosrowjerdi S, Mooradian M, Lydon C, Illei P, Zhang J, Peterson R, Ricciuti B, Nishino M, Zhang J, Roth JA, Grishman J, Anderson D, Little BP, Carter BW, Arbour K, Sauter JL, Mino-Kenudson M, Heymach JV, Digumarthy S, Shaw AT, Awad MM, Hellmann MD. Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression =50. Ann Oncol 31(3):404-411, 2020. e-Pub 2019. PMID: 32067682.
Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Roth JA, Swisher SG, Walsh GL, Vaporciyan AA, Mehran RJ, Antonoff MB. Hospital readmissions after pulmonary resection: post-discharge nursing telephone assessment identifies high risk patients. J Thorac Dis 12(3):184-190, 2020. PMID: 32274083.
Nelson DB, Mitchell KG, Wang J, Fujimoto J, Godoy M, Behrens C, Zheng X, Zhang J, Sepesi B, Vaporciyan AA, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Swisher SG, Moran CA, Kalhor N, Weissferdt A, Wistuba II, Roth JA, Antonoff MB. Immune regulatory markers of lepidic-pattern adenocarcinomas presenting as ground glass opacities. J Thorac Dis 12(3):329-337, 2020. PMID: 32274099.
Wu X, Wen CP, Ye Y, Tsai M, Wen C, Roth JA, Pu X, Chow WH, Huff C, Cunningham S, Huang M, Wu S, Tsao CK, Gu J, Lippman SM. Author Correction: Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. Sci Rep 10(1):5514, 2020. e-Pub 2020. PMID: 32251345.
Shewale JB, Correa AM, Brown EL, Leon-Novelo LG, Nyitray AG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Roth J, Vaporciyan AA, Swisher SG, Sepesi B. Time Trends of Perioperative Outcomes in Early-Stage Non-Small Cell Lung Cancer Resection Patients. Ann Thorac Surg 109(2):404-411, 2020. e-Pub 2019. PMID: 31539514.
Zhuo M, Guan Y, Yang X, Hong L, Wang Y, Li Z, Chen R, Abbas HA, Chang L, Gong Y, Wu N, Zhong J, Chen W, Chen H, Dong Z, Zhu X, Li J, Wang Y, An T, Wu M, Wang Z, Wang J, Roarty EB, Rinsurongkawong W, Lewis J, Roth JA, Swisher SG, Lee JJ, Heymach JV, Wistuba II, Kalhor N, Yang L, Yi X, Futreal PA, Glisson BS, Xia X, Zhang J, Zhao J. The prognostic and therapeutic role of genomic subtyping by sequencing tumor or cell-free DNA in pulmonary large-cell neuroendocrine carcinoma. Clin Cancer Res 26(4):892-901, 2020. e-Pub 2019. PMID: 31694833.
Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene 39(4):801-813, 2020. e-Pub 2019. PMID: 31554935.
Van Haren RM, Rajaram R, Correa AM, Mehran RJ, Antonoff MB, Hofstetter WL, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC, Roth JA. Preoperative Heparin for Lung Cancer Resection Increases Risk of Reoperation for Bleeding. Semin Thorac Cardiovasc Surg 32(2):337-343, 2020. e-Pub 2019. PMID: 31857153.
Mitchell KG, Nelson DB, Corsini EM, Correa AM, Erasmus JJ, Hofstetter WL, Mehran RJ, Roth JA, Swisher SG, Sepesi B, Walsh GL, Vaporciyan AA, Rice DC, Nguyen QN, Antonoff MB. Surveillance After Treatment of Non-Small-Cell Lung Cancer: A Call for Multidisciplinary Standardization. Innovations (Phila) 15(1):1556984519886281, 2020. e-Pub 2019. PMID: 31875755.
Nelson DB, Mitchell KG, Weston BR, Betancourt S, Maru D, Rice DC, Mehran RJ, Sepesi B, Antonoff MB, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Blum M, Hofstetter WL. Should Endoscopic Mucosal Resection Be Attempted for cT2N0 Esophageal Cancer?. Dis Esophagus 32(10):1-6, 2019. e-Pub 2019. PMID: 30888418.
Mulshine JL, Ujhazy P, Antman M, Burgess CM, Kuzmin I, Bunn PA, Johnson BE, Roth JA, Pass HI, Ross SM, Aldige CR, Wistuba II, Minna JD. From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later. J Cell Biochem. e-Pub 2019. PMID: 31803961.
Chen Y, Zhang R, Wang L, Correa AM, Pataer A, Xu Y, Zhang X, Ren C, Wu S, Meng QH, Fujimoto J, Jensen VB, Antonoff MB, Hofstetter WL, Mehran RJ, Pisimisis G, Rice DC, Sepesi B, Vaporciyan AA, Walsh GL, Swisher SG, Roth JA, Heymach JV, Fang B. Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice. Cancer 125(21):3738-3748, 2019. e-Pub 2019. PMID: 31287557.
Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Swisher SG, Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL. Mediastinal Nodal Involvement After Neoadjuvant Chemoradiation For Siewert II/III Adenocarcinoma. Ann Thorac Surg 108(3):845-851, 2019. e-Pub 2019. PMID: 31102632.
Mitchell KG, Parra ER, Nelson DB, Zhang J, Wistuba II, Fujimoto J, Roth JA, Antonoff MB, MD Anderson Lung Cancer Immune Microenvironment Working Group. Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 158(3):911-919.e6, 2019. e-Pub 2019. PMID: 31235357.
Corsini EM, Mitchell KG, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG, Roth JA, Hofstetter WL, Vaporciyan AA, Morris VK, Antonoff MB. Colorectal Cancer Mutations are Associated with Survival and Recurrence After Pulmonary Metastasectomy. J Surg Oncol 120(4):729-735, 2019. e-Pub 2019. PMID: 31290159.
Corsini EM, Mitchell KG, Sceusi EL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Hofstetter WL, Antonoff MB. Multidisciplinary Treatment of Thymic Neuroendocrine Tumors: Surgery Remains a Key Component. J Thorac Dis 11(8):3391-3398, 2019. PMID: 31559043.
Nelson DB, Mehran RJ, Mitchell KG, Rajaram R, Correa AM, Bassett RL, Antonoff MB, Hofstetter WL, Roth JA, Sepesi B, Swisher SG, Walsh GL, Vaporciyan AA, Rice DC. Robotic Assisted Lobectomy For Non-Small Cell Lung Cancer: A Comprehensive Institutional Experience. Ann Thorac Surg 108(2):370-376, 2019. e-Pub 2019. PMID: 31004583.
Meraz IM, Majidi M, Meng F, Shao R, Ha MJ, Neri S, Fang B, Lin SH, Tinkey PT, Shpall EJ, Morris J, Roth JA. An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses. Cancer Immunol Res 7(8):1267-1279, 2019. e-Pub 2019. PMID: 31186248.
Zhang Y, Roth JA, Yu H, Ye Y, Xie K, Zhao H, Chang DW, Huang M, Li H, Qu J, Wu X. A 5-MicroRNA Signature Identified from Serum MicroRNA Profiling Predicts Survival in Patients with Advanced Stage Non-Small Cell Lung Cancer. Carcinogenesis 40(5):643-650, 2019. e-Pub 2018. PMID: 30428030.
Negrao MV, Lam VK, Reuben A, Rubin ML, Landry LL, Roarty EB, Rinsurongkawong W, Lewis J, Roth JA, Swisher SG, Gibbons DL, Wistuba II, Papadimitrakopoulou V, Glisson BS, Blumenschein GR, Lee JJ, Heymach JV, Zhang J. PD-L1 expression, tumor mutational burden and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class I genotype in non-small cell lung cancer. J Thorac Oncol 14(6):1021-1031, 2019. e-Pub 2019. PMID: 30780001.
Nelson DB, Tayob N, Mitchell KG, Correa AM, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB, Roth JA, Rice DC, Vauthey JN, Mehran RJ. Surgical margins and risk of local recurrence after wedge resection of colorectal pulmonary metastases. J Thorac Cardiovasc Surg 157(4):1648-1655, 2019. e-Pub 2018. PMID: 30635188.
Nelson DB, Rice DC, Mitchell KG, Tsao AS, Vaporciyan AA, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Gomez DR, Mehran RJ, Sepesi B. Defining the role of adjuvant radiotherapy for malignant pleural mesothelioma: a propensity-matched landmark analysis of the National Cancer Database. J Thorac Dis 11(4):1269-1278, 2019. PMID: 31179069.
Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Mehran RJ, Vaporciyan AA, Walsh GL, Roth JA, Swisher SG, Antonoff MB. Ground Glass Lesions on Chest Imaging: Evaluation of Reported Incidence in Cancer Patients Using Natural Language Processing. Ann Thorac Surg 107(3):936-940, 2019. e-Pub 2018. PMID: 30612991.
Elamin YY, Gomez DR, Antonoff MB, Robichaux JP, Tran H, Shorter MK, Bohac JM, Negrao MV, Le X, Rinsurogkawong W, Lewis J, Lacerda L, Roarty EB, Swisher SG, Roth JA, Zhang J, Papadimitrakopoulou V, Heymach JV. Local consolidation therapy (LCT) after first line tyrosine kinase inhibitor (TKI) for patients with EGFR mutant metastatic non-small cell lung cancer (NSCLC). Clin Lung Cancer 20(1):43-47, 2019. e-Pub 2018. PMID: 30343004.
Lam VK, Tran HT, Banks KC, Lanman RB, Rinsurongkawong W, Peled N, Lewis J, Lee JJ, Roth J, Roarty EB, Swisher S, Talasaz A, Futreal PA, Papadimitrakopoulou V, Heymach JV, Zhang J. Targeted tissue and cell-free tumor DNA sequencing of advanced lung squamous cell carcinoma reveals clinically significant prevalence of actionable alterations. Clin Lung Cancer 20(1):30-36.e3, 2019. e-Pub 2018. PMID: 30279110.
Yan X, Zhang X, Wang L, Zhang R, Pu X, Wu S, Li L, Tong P, Wang J, Meng QH, Jensen VB, Girard L, Minna JD, Roth JA, Swisher SG, Heymach JV, Fang B. Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis. Cancer Res 79(1):125-132, 2019. e-Pub 2018. PMID: 30401714.
Xie Y, Lu W, Wang S, Tang X, Tang H, Zhou Y, Moran C, Behrens C, Roth JA, Zhou Q, Johnson DH, Swisher SG, Heymach JV, Papadimitrakopoulou VA, Xiao G, Minna JD, Wistuba II. Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer. Clin Cancer Res 25(1):150-157, 2019. e-Pub 2018. PMID: 30287547.
Baity M, Wang L, Correa AM, Zhang X, Zhang R, Pataer A, Wu S, Meng QH, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Zhao M, Gu J, Fang B. Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization. Am J Cancer Res 9(6):1201-1211, 2019. e-Pub 2019. PMID: 31285952.
Le X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, Hicks JK, Lovinger KL, Roarty E, Rinsurongkawong W, Tang M, Sun H, Elamin Y, Lacerda LC, Lewis J, Roth JA, Swisher SG, Lee JJ, William WN, Glisson BS, Zhang J, Papadimitrakopoulou VA, Gray JE, Heymach JV. Landscape of EGFR -dependent and -independent resistance mechanisms to osimertinib and continuation therapy post-progression in EGFR-mutant NSCLC. Clin Cancer Res 24(24):6195-6203, 2018. e-Pub 2018. PMID: 30228210.
Kim MP, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Erasmus JJ, Swisher SG. Occult stage IIIA-N2 patients have excellent overall survival with initial surgery. J Thorac Dis 10(12):6670-6676, 2018. PMID: 30746212.
Pu X, Zhang R, Wang L, Chen Y, Xu Y, Pataer A, Meraz IM, Zhang X, Wu S, Wu L, Su D, Mao W, Heymach JV, Roth JA, Swisher SG, Fang B. Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer. J Transl Med 16(1):328, 2018. e-Pub 2018. PMID: 30477533.
Shewale JB, Mitchell KG, Nelson DB, Conley AP, Rice DC, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Mehran RJ, Vaporciyan AA, Weissferdt A, Sepesi B. Predictors of survival after resection of primary sarcomas of the chest wall-A large, single-institution series. J Surg Oncol 118(3):518-524, 2018. e-Pub 2018. PMID: 30109699.
Nelson DB, Lapid DJ, Mitchell KG, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB. Perioperative Outcomes for Stage I Non-Small Cell Lung Cancer: Differences between Men and Women. Ann Thorac Surg. e-Pub 2018. PMID: 30118712.
Van Haren RM, Mehran RJ, Mena GE, Correa AM, Antonoff MB, Baker CM, Woodard TC, Hofstetter WL, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC. Enhanced Recovery Decreases Pulmonary and Cardiac Complications Following Thoracotomy for Lung Cancer. Ann Thorac Surg 106(1):272-279, 2018. e-Pub 2018. PMID: 29530770.
Nelson DB, Godoy MCB, Benveniste MF, Shewale JB, Spicer JD, Mitchell KG, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB. Clinicoradiographic Predictors of Aggressive Biology in Lung Cancer with Ground Glass Components. Ann Thorac Surg 106(1):235-241, 2018. e-Pub 2018. PMID: 29534957.
Zhang L, Lin J, Ye Y, Oba T, Gentile E, Lian J, Wang J, Zhao Y, Gu J, Wistuba II, Roth JA, Ji L, Wu X. Serum microRNA-150 predicts prognosis for early-stage non-small cell lung cancer and promotes tumor cell proliferation by targeting tumor suppressor gene SRCIN1. Clin Pharmacol Ther 103(6):1061-1073, 2018. e-Pub 2017. PMID: 28891208.
Shewale JB, Nelson DB, Rice DC, Sepesi B, Hofstetter WL, Mehran RJ, Vaporciyan AA, Walsh GL, Swisher SG, Roth JA, Antonoff MB. Natural History of Ground Glass Lesions among Patients with Previous Lung Cancer. Ann Thorac Surg 105(6):1671-1677, 2018. e-Pub 2018. PMID: 29432718.
Sepesi B, Ye Y, Mitchell KG, Zhang L, Gu J, Ji L, Antonoff MB, Hofstetter WL, Rice DC, Mehran RJ, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Wu X. Genetic variants in cytokine signaling pathways and clinical outcomes in early-stage lung cancer patients. J Thorac Cardiovasc Surg 155(6):2635-2645.e15, 2018. e-Pub 2018. PMID: 29548588.
Pataer A, Shao R, Correa AM, Behrens C, Roth JA, Vaporciyan AA, Wistuba II, Swisher SG. Major pathologic response (MPR) and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy. Cancer Med 7(6):2405-2414, 2018. e-Pub 2018. PMID: 29673125.
Wang JF, Pu X, Zhang X, Chen K, Xi Y, Wang J, Mao X, Zhang J, Heymach JV, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Meng QH, Shaw KR, Eterovic AK, Fang B. Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing. Cancer 124(5):1061-1069, 2018. e-Pub 2017. PMID: 29178133.
Mehran RJ, Martin LW, Roth JA. Comparison of outcomes between muscle-sparing thoracotomy and video-assisted thoracic surgery in patients with cT1 N0 M0 lung cancer. J Thorac Cardiovasc Surg 155(3):1307, 2018. PMID: 29452469.
Meraz IM, Majidi M, Cao X, Lin H, Li L, Wang J, Baladandayuthapani V, Rice D, Sepesi B, Ji L, Roth JA. TUSC2 Immunogene Therapy Synergizes with Anti-PD-1 through Enhanced Proliferation and Infiltration of Natural Killer Cells in SyngeneicKras-Mutant Mouse Lung Cancer Models. Cancer Immunol Res 6(2):163-177, 2018. e-Pub 2018. PMID: 29339375.
Shimodaira Y, Slack RS, Harada K, Chen HC, Sagebiel T, Bhutani MS, Lee JH, Weston B, Elimova E, Lin Q, Amlashi FG, Mizrak Kaya D, Blum MA, Roth JA, Swisher SG, Skinner HD, Hofstetter WL, Rogers JE, Mares J, Thomas I, Maru DM, Komaki R, Walsh G, Ajani JA. Influence of induction chemotherapy in trimodality therapy-eligible oesophageal cancer patients: secondary analysis of a randomised trial. Br J Cancer 118(3):331-337, 2018. e-Pub 2017. PMID: 29235564.
Atay SM, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh G, Antonoff MB. Perioperative Outcomes of Patients Undergoing Lobectomy on Clopidogrel. Ann Thorac Surg 104(6):1821-1828, 2017. e-Pub 2017. PMID: 28987393.
Harada K, Wang X, Shimodaira Y, Sagebiel T, Bhutani MS, Lee JH, Weston B, Elimova E, Lin Q, Amlashi FG, Mizrak Kaya D, Lopez A, Blum Murphy MA, Roth JA, Swisher SG, Skinner HD, Hofstetter WL, Rogers JE, Thomas I, Maru DM, Komaki R, Walsh G, Ajani JA. Early metabolic change after induction chemotherapy predicts histologic response and prognosis in patients with esophageal cancer: Secondary analysis of a Randomized Trial. Target Oncol. e-Pub 2017. PMID: 29218623.
Shen J, Ye Y, Chang DW, Huang M, Heymach JV, Roth JA, Wu X, Zhao H. Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy. Lung Cancer 114:70-78, 2017. e-Pub 2017. PMID: 29173770.
Cao X, Zhao Y, Wang J, Dai B, Gentile E, Lin J, Pu X, Ji L, Wu S, Meraz I, Majidi M, Roth JA. TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC). Oncotarget 8(64):107621-107629, 2017. e-Pub 2017. PMID: 29296193.
Nelson DB, Rice DC, Niu J, Atay SM, Vaporciyan AA, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Tsao AS, Gomez DR, Giordano SH, Mehran RJ, Sepesi B. Predictors of trimodality therapy and trends in therapy for malignant pleural mesothelioma. Eur J Cardiothorac Surg. e-Pub 2017. PMID: 29211849.
Huang X, Cao M, Wu S, Wang L, Hu J, Mehran RJ, Roth JA, Swisher SG, Wang RY, Kantarjian HM, Andreeff M, Sun X, Fang B. Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with Inhibitions of cFLIP Expression and PI3K/AKT/mTOR Activities. Oncotarget 8(60):102150-102160, 2017. e-Pub 2017. PMID: 29254232.
Nelson DB, Rice DC, Niu J, Atay S, Vaporciyan AA, Antonoff M, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Tsao A, Gomez D, Giordano SH, Mehran R, Sepesi B. Long-Term Survival Outcomes of Cancer-Directed Surgery for Malignant Pleural Mesothelioma: Propensity Score Matching Analysis. J Clin Oncol 35(29):JCO2017738401, 2017. e-Pub 2017. PMID: 28817374.
Sun B, Brooks ED, Komaki RU, Liao Z, Jeter MD, McAleer MF, Allen PK, Balter PA, Welsh JD, O'Reilly MS, Gomez D, Hahn SM, Roth JA, Mehran RJ, Heymach JV, Chang JY. 7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer: Results of a phase 2 clinical trial. Cancer 123(16):3031-3039, 2017. e-Pub 2017. PMID: 28346656.
Lin J, Zandi R, Shao R, Gu J, Ye Y, Wang J, Zhao Y, Pertsemlidis A, Wistuba II, Wu X, Roth JA, Ji L. A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling. Sci Rep 7(1):9029, 2017. e-Pub 2017. PMID: 28831115.
Zhang Y, Zhang L, Li R, Chang DW, Ye Y, Minna JD, Roth JA, Han B, Wu X. Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility. Ann Oncol 28(7):1625-1630, 2017. e-Pub 2017. PMID: 28383694.
Gentile E, Oba T, Lin J, Shao R, Meng F, Cao X, Lin HY, Mourad M, Pataer A, Baladandayuthapani V, Cai D, Roth JA, Ji L. Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics. Oncotarget 8(29):48222-48239, 2017. e-Pub 2017. PMID: 28637023.
Bassuner JK, Rice DC, Antonoff MB, Correa AM, Walsh GL, Vaporciyan AA, Garg N, Sepesi B, Swisher SG, Hofstetter WL, Roth JA, Mehran RJ. Polytetrafluoroethylene or Acellular Dermal Matrix for diaphragmatic reconstruction?. Ann Thorac Surg 103(6):1710-1714, 2017. e-Pub 2017. PMID: 28366460.
Zhang L, Ye Y, Tu H, Hildebrandt MA, Zhao L, Heymach JV, Roth JA, Wu X. MicroRNA-related genetic variants in iron regulatory genes, dietary iron intake, microRNAs and lung cancer risk. Ann Oncol 28(5):1124-1129, 2017. PMID: 28453699.
Li R, Gu J, Heymach JV, Shu X, Zhao L, Han B, Ye Y, Roth J, Wu X. Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinum-based chemotherapy. Carcinogenesis 38(4):419-424, 2017. e-Pub 2017. PMID: 28186269.
Peters HL, Tripathi SC, Kerros C, Katayama H, Garber HR, St John LS, Federico L, Meraz IM, Roth JA, Sepesi B, Majidi M, Ruisaard K, Clise-Dwyer K, Roszik J, Gibbons DL, Heymach JV, Swisher SG, Bernatchez C, Alatrash G, Hanash S, Molldrem JJ. Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells. Cancer Immunol Res 5(4):319-329, 2017. e-Pub 2017. PMID: 28254787.
Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, Meraz IM, Zhang X, Wang JF, Gibbons DL, Mehran RJ, Swisher SG, Roth JA, Fang B. Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Oncoimmunology 7(1):e1376156, 2017. e-Pub 2017. PMID: 29296537.
Spicer JD, Shewale JB, Antonoff MB, Correa AM, Hofstetter WB, Rice DC, Vaporciyan AA, Mehran RJ, Walsh GL, Roth JA, Swisher SG, Sepesi B. The Influence of Reconstructive Technique on Perioperative Pulmonary and Infectious Outcomes Following Chest Wall Resection. Ann Thorac Surg 102(5):1653-1659, 2016. e-Pub 2016. PMID: 27526650.
Xiaobo C, Majidi M, Feng M, Shao R, Wang J, Zhao Y, Baladandayuthapani V, Song J, Fang B, Ji L, Mehran R, Roth JA. TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin. Sci Rep 6:35741, 2016. e-Pub 2016. PMID: 27845352.
Wu X, Wen CP, Ye Y, Tsai M, Wen C, Roth JA, Pu X, Chow WH, Huff C, Cunningham S, Huang M, Wu S, Tsao CK, Gu J, Lippman SM. Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. Sci Rep 6:36482, 2016. e-Pub 2016. PMID: 27805040.
Mehran RJ, Roth JA. Quality of life after video-assisted surgery for lung cancer. Lancet Oncol 17(8):e315-6, 2016. PMID: 27511151.
Antonoff MB, Ragalie W, Correa AM, Spicer JD, Sepesi B, Roth JA, Walsh GL, Hofstetter WL, Swisher SG, Rice DC, Vaporciyan AA, Mehran RJ. Results of Post-Discharge Nursing Telephone Assessments: Persistent Symptoms Common Among Pulmonary Resection Patients. Ann Thorac Surg 102(1):276-81, 2016. e-Pub 2016. PMID: 27083250.
Lin J, Xu K, Roth JA, Ji L. Detection of siRNA-mediated target mRNA cleavage activities in human cells by a novel stem-loop array RT-PCR analysis. Biochem Biophys Rep 6:16-23, 2016. PMID: 26949742.
Xu K, Lin J, Zandi R, Roth JA, Ji L. MicroRNA-mediated target mRNA cleavage and 3'-uridylation in human cells. Sci Rep 6:30242, 2016. e-Pub 2016. PMID: 27440378.
Melkonian SC, Daniel CR, Ye Y, Pierzynski JA, Roth JA, Wu X. Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev 25(3):532-9, 2016. PMID: 26944871.
Sepesi B, Schmidt HE, Lada M, Correa AM, Walsh GL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Ajani JA, Watson TJ, Swisher SG, Low DE, Hofstetter WL. Survival in Patients with Esophageal Adenocarcinoma Undergoing Trimodality Therapy Is Independent of Regional Lymph Node Location. Ann Thorac Surg 101(3):1075-81, 2016. e-Pub 2015. PMID: 26680311.
Chang JY, Senan S, Smit EF, Roth JA. Stereotactic radiotherapy or surgery for early-stage non-small-cell lung cancer - Authors' reply. Lancet Oncol 17(2):e42-3, 2016. PMID: 26868349.
Lin J, Xu K, Wei J, Heimberger AB, Roth JA, Ji L. MicroRNA-124 Suppresses Tumor Cell Proliferation and Invasion by Targeting CD164 Signaling Pathway in Non-Small Cell Lung Cancer. J Gene Ther 2(1):6, 2016. e-Pub 2016. PMID: 27376157.
Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, Dai B, Cao M, Shao R, Zhang R, Majidi M, Ji L, Heymach JV, Wang M, Pan S, Minna J, Mehran RJ, Swisher SG, Roth JA, Fang B. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget 7(3):3548-58, 2016. PMID: 26657290.
Li R, Pu X, Chang JY, Ye Y, Komaki R, Minna JD, Roth JA, Han B, Wu X. MiRNA-related genetic variations associated with radiotherapy-induced toxicities in patients with locally advanced non-small cell lung cancer. PLoS One 11(3):e0150467, 2016. e-Pub 2016. PMID: 26991123.
Tu H, Heymach JV, Wen CP, Ye Y, Pierzynski JA, Roth JA, Wu X. Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S. Sci Rep 6:26760, 2016. e-Pub 2016. PMID: 27230571.
Chang JY, Senan S, Smit EF, Roth JA. Surgery versus SABR for resectable non-small-cell lung cancer - Authors' reply. Lancet Oncol 16(8):e374-5, 2015. PMID: 26248841.
Chang JY, Senan S, Paul MA, Mehran RJ, Louie AV, Balter P, Groen HJ, McRae SE, Widder J, Feng L, van den Borne BE, Munsell MF, Hurkmans C, Berry DA, van Werkhoven E, Kresl JJ, Dingemans AM, Dawood O, Haasbeek CJ, Carpenter LS, De Jaeger K, Komaki R, Slotman BJ, Smit EF, Roth JA. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol 16(6):630-7, 2015. e-Pub 2015. PMID: 25981812.
Shewale JB, Correa AM, Baker CM, Villafane-Ferriol N, Hofstetter WL, Jordan VS, Kehlet H, Lewis KM, Mehran RJ, Summers BL, Schaub D, Wilks SA, Swisher SG, University of Texas MD Anderson Esophageal Cancer Collaborative Group (Roth JA). Impact of a Fast-track Esophagectomy Protocol on Esophageal Cancer Patient Outcomes and Hospital Charges. Ann Surg 261(6):1114-23, 2015. PMID: 25243545.
Guo C, Hao C, Shao R, Fang B, Correa AM, Hofstetter WL, Roth JA, Behrens C, Kalhor N, Wistuba II, Swisher SG, Pataer A. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget 6(13):11114-24, 2015. e-Pub 2015. PMID: 25798539.
Kim ES, Ye Y, Vaporciyan AA, Xing J, Huang M, Gu J, Roth JA, Lippman SM, Wu X. Telomere length and recurrence risk after curative resection in patients with early-stage non-small cell lung cancer: a prospective cohort study. J Thorac Oncol 10(2):302-8, 2015. e-Pub 2014. PMID: 25299235.
Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett 357(1):179-85, 2015. e-Pub 2014. PMID: 25444907.
Kim MP, Correa AM, Hofstetter W, Mehran R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Erasmus JJ, Swisher SG. Limitations of 18F-2-Deoxy-d-Glucose Positron Emission Tomography in N1 Detection in Patients With Pathologic Stage II-N1 and Implications for Management. Ann Thorac Surg 99(2):414-20, 2015. e-Pub 2014. PMID: 25497068.
Huang X, Cao M, Wang L, Wu S, Liu X, Li H, Zhang H, Wang RY, Sun X, Wei C, Baggerly KA, Roth JA, Wang M, Swisher SG, Fang B. Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380. Oncotarget 6(1):345-54, 2015. PMID: 25514600.
Dai B, Yan S, Lara-Guerra H, Kawashima H, Sakai R, Jayachandran G, Majidi M, Mehran R, Wang J, Bekele BN, Baladandayuthapani V, Yoo SY, Wang Y, Ying J, Meng F, Ji L, Roth JA. Exogenous restoration of TUSC2 expression induces responsiveness to erlotinib in wildtype epidermal growth factor receptor (EGFR) lung cancer cells through context specific pathways resulting in enhanced therapeutic efficacy. PLoS One 10(6):e0123967, 2015. e-Pub 2015. PMID: 26053020.
Hildebrandt MA, Roth JA, Vaporciyan AA, Pu X, Ye Y, Correa AM, Kim JY, Swisher SG, Wu X. Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. Sci Rep 5:12068, 2015. e-Pub 2015. PMID: 26165383.
Wu S, Wang L, Huang X, Cao M, Hu J, Li H, Zhang H, Sun X, Meng QH, Hofstetter WL, Roth JA, Swisher SG, Fang B. Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380. Bioorg Med Chem 22(19):5234-40, 2014. e-Pub 2014. PMID: 25182964.
Pu X, Hildebrandt MA, Lu C, Roth JA, Stewart DJ, Zhao Y, Heist RS, Ye Y, Chang DW, Su L, Minna JD, Lippman SM, Spitz MR, Christiani DC, Wu X. Inflammation-related Genetic Variations and Survival for Advanced Non-Small Cell Lung Cancer Receiving First-line Chemotherapy. Clin Pharmacol Ther 96(3):360-9, 2014. e-Pub 2014. PMID: 24755914.
Gao W, Wang M, Wang L, Lu H, Wu S, Dai B, Ou Z, Zhang L, Heymach JV, Gold KA, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells. J Natl Cancer Inst 106(9), 2014. e-Pub 2014. PMID: 25214559.
Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X. Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clin Pharmacol Ther. e-Pub 2014. PMID: 25054431.
Coscio A, Chang DW, Roth JA, Ye Y, Gu J, Yang P, Wu X. Genetic variants of the Wnt signaling pathway as predictors of recurrence and survival in early-stage non-small cell lung cancer patients. Carcinogenesis 35(6):1284-91, 2014. e-Pub 2014. PMID: 24517998.
NSCLC Meta-analysis Collaborative Group (Roth JA). Preoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet 383(9928):1561-71, 2014. e-Pub 2014. PMID: 24576776.
Sanchez-Espiridion B, Chen M, Chang JY, Lu C, Chang DW, Roth JA, Wu X, Gu J. Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case-Control Study in Caucasians. Cancer Res 74(9):2476-86, 2014. e-Pub 2014. PMID: 24618342.
Stewart DJ, Nunez MI, Behrens C, Liu D, Lin YH, Lee JJ, Roth J, Heymach J, Swisher SG, Hong WK, Wistuba II. Membrane Carbonic Anhydrase IX Expression and Relapse Risk in Resected Stage I-II Non-Small-Cell Lung Cancer. J Thorac Oncol 9(5):675-84, 2014. PMID: 24662455.
Chang JY, Li QQ, Xu QY, Allen PK, Rebueno N, Gomez DR, Balter P, Komaki R, Mehran R, Swisher SG, Roth JA. Stereotactic ablative radiation therapy for centrally located early stage or isolated parenchymal recurrences of non-small cell lung cancer: how to fly in a "no fly zone". Int J Radiat Oncol Biol Phys 88(5):1120-8, 2014. PMID: 24661665.
Stephens N, Rice D, Correa A, Hofstetter W, Mehran R, Roth J, Walsh G, Vaporciyan A, Swisher S. Thoracoscopic lobectomy is associated with improved short-term and equivalent oncological outcomes compared with open lobectomy for clinical Stage I non-small-cell lung cancer: a propensity-matched analysis of 963 cases. Eur J Cardiothorac Surg, 2014.
Francis AM, Correa AM, Betancourt-Cuellar SL, Kim JY, Sepesi B, Ajani JA, Komaki R, Erasmus J, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Hofstetter WL, Swisher SG. Esophageal Tumor Thickness on Computed Tomography as a Predictor of Residual Tumor in Esophageal Adenocarcinoma Following Preoperative Chemoradiation. J Surg Res 186(2):680, 2014.
Kuroda S, Tam J, Roth JA, Sokolov K, Ramesh R. EGFR-Targeted Plasmonic Magnetic Nanoparticles Suppress Lung Tumor Growth by Abrogating G2/M Cell-Cycle Arrest and Inducing DNA Damage. Int J Nanomedicine 9:3825-39, 2014. e-Pub 2014. PMID: 25143731.
Hellmann MD, Chaft JE, William WN, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG, University of Texas MD Anderson Lung Cancer Collaborative Group (Roth JA). Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol 15(1):e42-50, 2014. PMID: 24384493.
Lu H, Wang L, Gao W, Meng J, Dai B, Wu S, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells. Mol Cancer Ther 12(12):2864-73, 2013. e-Pub 2013. PMID: 24130049.
Ajani JA, Xiao L, Roth JA, Hofstetter WL, Walsh G, Komaki R, Liao Z, Rice DC, Vaporciyan AA, Maru DM, Lee JH, Bhutani MS, Eid A, Yao JC, Phan AP, Halpin A, Suzuki A, Taketa T, Thall PF, Swisher SG. A phase II randomized trial of induction chemotherapy versus no induction chemotherapy followed by preoperative chemoradiation in patients with esophageal cancer. Ann Oncol 24(11):2844-9, 2013. e-Pub 2013. PMID: 23975663.
Ganeshan DM, Correa AM, Bhosale P, Vaporciyan AA, Rice D, Mehran RJ, Walsh GL, Iyer R, Roth JA, Swisher SG, Hofstetter WL. Diaphragmatic Hernia After Esophagectomy in 440 Patients With Long-Term Follow-Up. Ann Thorac Surg 96(4):1138-45, 2013. e-Pub 2013. PMID: 23810174.
Han L, Ravoori M, Wu G, Sakai R, Yan S, Singh S, Xu K, Roth JA, Ji L, Kundra V. Somatostatin receptor type 2-based reporter expression after plasmid-based in vivo gene delivery to non-small cell lung cancer. Mol Imaging 12(7):1-10, 2013. PMID: 23962694.
Chang JY, Liu YH, Zhu Z, Welsh JW, Gomez DR, Komaki R, Roth JA, Swisher SG. Stereotactic ablative radiotherapy: A potentially curable approach to early stage multiple primary lung cancer. Cancer 119(18):3402-10, 2013. e-Pub 2013. PMID: 23798353.
Dai B, Yoo SY, Bartholomeusz G, Graham RA, Majidi M, Yan S, Meng J, Ji L, Coombes K, Minna JD, Fang B, Roth JA. KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res 73(17):5532-43, 2013. e-Pub 2013. PMID: 23824739.
Francis AM, Sepesi B, Correa AM, Blum MA, Erasmus JJ, Lee JH, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Welsh JW, Swisher SG, Hofstetter WL, University of Texas MD Anderson Esophageal Cancer Group. The Influence of Histopathologic Tumor Viability on Long-term Survival and Recurrence Rates Following Neoadjuvant Therapy for Esophageal Adenocarcinoma. Ann Surg 258(3):500-7, 2013. PMID: 24022442.
Wang Y, Gu J, Roth JA, Hildebrandt MA, Lippman SM, Ye Y, Minna JD, Wu X. Pathway-Based Serum microRNA Profiling and Survival in Patients with Advanced Stage Non-Small Cell Lung Cancer. Cancer Res 73(15):4801-9, 2013. e-Pub 2013. PMID: 23774211.
Shirvani SM, Chang JY, Roth JA. Can stereotactic ablative radiotherapy in early stage lung cancers produce comparable success as surgery?. Thorac Surg Clin 23(3):369-81, 2013. PMID: 23931020.
Wu X, Wang L, Ye Y, Aakre JA, Pu X, Chang GC, Yang PC, Roth JA, Marks RS, Lippman SM, Chang JY, Lu C, Deschamps C, Su WC, Wang WC, Huang MS, Chang DW, Li Y, Pankratz VS, Minna JD, Hong WK, Hildebrandt MA, Hsiung CA, Yang P. Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers. Cancer Res 73(13):4028-38, 2013. e-Pub 2013. PMID: 23704207.
Amini A, Lou F, Correa AM, Baldassarre R, Rimner A, Huang J, Roth JA, Swisher SG, Vaporciyan AA, Lin SH. Predictors for Locoregional Recurrence for Clinical Stage III-N2 Non-small Cell Lung Cancer with Nodal Downstaging After Induction Chemotherapy and Surgery. Ann Surg Oncol 20(6):1934-40, 2013. e-Pub 2012. PMID: 23263700.
David E, Thall PF, Kalhor N, Hofstetter WL, Rice DC, Roth JA, Swisher SG, Walsh GL, Vaporciyan AA, Wei C, Mehran RJ. Visceral pleural invasion is not predictive of survival in patients with lung cancer and smaller tumor size. Ann Thorac Surg 95(6):1872-7, 2013. e-Pub 2013. PMID: 23643547.
Guo C, Shao R, Correa AM, Behrens C, Johnson FM, Raso MG, Prudkin L, Solis LM, Nunez MI, Fang B, Roth JA, Wistuba II, Swisher SG, Lin T, Pataer A. Prognostic Significance of Combinations of RNA-Dependent Protein Kinase and EphA2 Biomarkers for NSCLC. J Thorac Oncol 8(3):301-308, 2013. PMID: 23370317.
He Y, Gong Y, Lin J, Chang DW, Gu J, Roth JA, Wu X. Ionizing Radiation-Induced γ-H2AX Activity in Whole Blood Culture and the Risk of Lung Cancer. Cancer Epidemiol Biomarkers Prev 22(3):443-51, 2013. e-Pub 2013. PMID: 23300022.
Pu X, Roth JA, Hildebrandt MA, Ye Y, Wei H, Minna JD, Lippman SM, Wu X. MicroRNA-related genetic variants associated with clinical outcomes in early-stage non-small cell lung cancer patients. Cancer Res 73(6):1867-75, 2013. e-Pub 2013. PMID: 23378343.
Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, Roth JA, Mehran R, Hofstetter W, Swisher SG, Wu X, Fang B. Insulin-Like Growth Factor Binding Protein-2 Level Is Increased in Blood of Lung Cancer Patients and Associated With Poor Survival. PLoS One 8(9):e74973, 2013. e-Pub 2013. PMID: 24069370.
Meng J, Majidi M, Fang B, Ji L, Bekele BN, Minna JD, Roth JA. The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to The AKT Inhibitor MK2206 in LKB1-dependent Manner. PLoS One 8(10):e77067, 2013. e-Pub 2013. PMID: 24146957.
Blackmon SH, Stephens EH, Correa AM, Hofstetter W, Kim MP, Mehran RJ, Rice DC, Roth JA, Swisher SG, Walsh GL, Vaporciyan AA. Predictors of Recurrent Pulmonary Metastases and Survival After Pulmonary Metastasectomy for Colorectal Cancer. Ann Thorac Surg 94(6):1802-9, 2012. e-Pub 2012. PMID: 23063195.
Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X. Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study. Clin Cancer Res 18(21):5983-91, 2012. e-Pub 2012. PMID: 22977190.
Sepesi B, Swisher SG, Walsh GL, Correa A, Mehran RJ, Rice D, Roth J, Vaporciyan A, Hofstetter WL. Omental reinforcement of the thoracic esophagogastric anastomosis: An analysis of leak and reintervention rates in patients undergoing planned and salvage esophagectomy. J Thorac Cardiovasc Surg 144(5):1146-50, 2012. e-Pub 2012. PMID: 22939861.
Blackmon SH, Correa AM, Skoracki R, Chevray PM, Kim MP, Mehran RJ, Rice DC, Roth JA, Swisher SG, Vaporciyan AA, Yu P, Walsh GL, Hofstetter WL. Super-Charged Pedicled Jejunal Interposition for Esophageal Replacement: A 10 Year Experience. Ann Thorac Surg 94(4):1104-11; discussion 1111-3, 2012. e-Pub 2012. PMID: 22939245.
Marks JL, Hofstetter W, Correa AM, Mehran RJ, Rice D, Roth J, Walsh G, Vaporciyan A, Erasmus J, Chang J, Maru D, Lee JH, Lee J, Ajani JA, Swisher SG. Salvage Esophagectomy After Failed Definitive Chemoradiation for Esophageal Adenocarcinoma. Ann Thorac Surg 94(4):1126-32; discussion 1132-3, 2012. e-Pub 2012. PMID: 22921233.
Kim JY, Hildebrandt MA, Pu X, Ye Y, Correa AM, Vaporciyan AA, Wu X, Roth JA. Variations in the vascular endothelial growth factor pathway predict pulmonary complications. Ann Thorac Surg 94(4):1079-84; discussion 1084-5, 2012. e-Pub 2012. PMID: 22795057.
Amini A, Correa AM, Komaki R, Chang JY, Tsao AS, Roth JA, Swisher SG, Rice DC, Vaporciyan AA, Lin SH. The Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy. Ann Thorac Surg 94(3):914-20, 2012. e-Pub 2012. PMID: 22819472.
Huschka R, Barhoumi A, Liu Q, Roth JA, Ji L, Halas NJ. Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. ACS Nano 6(9):7681-91, 2012. e-Pub 2012. PMID: 22862291.
Manyam G, Payton MA, Roth JA, Abruzzo LV, Coombes KR. Relax with CouchDB - Into the non-relational DBMS era of Bioinformatics. Genomics 100(1):1-7, 2012. e-Pub 2012. PMID: 22609849.
Liu X, Guo W, Wu S, Wang L, Wang J, Dai B, Kim ES, Heymach JV, Wang M, Girard L, Minna J, Roth JA, Swisher SG, Fang B. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochem Pharmacol 83(10):1456-64, 2012. e-Pub 2012. PMID: 22387047.
Pataer A, Kalhor N, Correa AM, Raso MG, Erasmus JJ, Kim ES, Behrens C, Lee JJ, Roth JA, Stewart DJ, Vaporciyan AA, Wistuba II, Swisher SG, University of Texas M. D. Anderson Lung Cancer Collaborative Research Group. Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy. J Thorac Oncol 7(5):825-32, 2012. PMID: 22481232.
Harvin JA, Lahat G, Correa AM, Lee J, Maru D, Ajani J, Marom EM, Welsh J, Bhutani MS, Walsh G, Roth J, Mehran R, Vaporciyan A, Rice D, Swisher S, Hofstetter W. Neoadjuvant chemoradiotherapy followed by surgery for esophageal adenocarcinoma: significance of microscopically positive circumferential radial margins. J Thorac Cardiovasc Surg 143(2):412-20, 2012. e-Pub 2011. PMID: 22172216.
Gomez DR, Cox JD, Roth JA, Allen PK, Wei X, Mehran RJ, Kim JY, Swisher SG, Rice DC, Komaki R. A prospective phase 2 study of surgery followed by chemotherapy and radiation for superior sulcus tumors. Cancer 118(2):444-51, 2012. e-Pub 2011. PMID: 21713767.
He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B. Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters. PLoS One 7(2):e31087, 2012. e-Pub 2012. PMID: 22348039.
Kim JY, Correa AM, Vaporciyan AA, Roth JA, Mehran RJ, Walsh GL, Rice DC, Ajani JA, Maru DM, Bhutani MS, Welsh J, Marom EM, Swisher SG, Hofstetter WL. Does the Timing of Esophagectomy After Chemoradiation Affect Outcome?. Ann Thorac Surg 93(1):207-13, 2012. e-Pub 2011. PMID: 21962263.
Wagner KW, Ye Y, Lin J, Vaporciyan AA, Roth JA, Wu X. Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non-Small Cell Lung Cancer Patients. Clin Cancer Res 18(2):585-92, 2012. PMID: 22252258.
Lu C, Stewart DJ, Lee JJ, Ji L, Ramesh R, Jayachandran G, Nunez MI, Wistuba II, Erasmus JJ, Hicks ME, Grimm EA, Reuben JM, Baladandayuthapani V, Templeton NS, McMannis JD, Roth JA. Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans. PLoS One 7(4):e34833, 2012. e-Pub 2012. PMID: 22558101.
Chang JY, Liu H, Balter P, Komaki R, Liao Z, Welsh J, Mehran RJ, Roth JA, Swisher SG. Clinical outcome and predictors of survival and pneumonitis after stereotactic ablative radiotherapy for stage I non-small cell lung cancer. Radiat Oncol 7:152, 2012. e-Pub 2012. PMID: 22963661.
Zandi R, Xu K, Poulsen HS, Roth JA, Ji L. Overexpression of the Novel Tumor Suppressor Gene FUS1 Suppresses the Growth of Small Cell Lung Cancer Cells. J Clinic Experiment Pathol S5:001, 2011.
He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II, Swisher SG, Pataer A. The Role of PKR/eIF2a Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer. PLoS One 6(11):e24855, 2011.
Xie Y, Xiao G, Coombes KR, Behrens C, Solis LM, Raso G, Girard L, Erickson HS, Roth J, Heymach JV, Moran C, Danenberg K, Minna JD, Wistuba II. Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non-Small-Cell Lung Cancer Patients. Clin Cancer Res 17(17):5705-14, 2011. e-Pub 2011. PMID: 21742808.
Kim MP, Chen Y, Bekele BN, Lopez A, Khanna A, Chen JQ, Spitz MR, Behrens C, Solis L, Wismach M, Ji L, Wistuba II, Roth JA, Katz RL. Activating enhancer-binding protein-2ß nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection. Ann Thorac Surg 92(3):1044-50, 2011. PMID: 21871297.
Lin J, Xu K, Gitanjali J, Roth JA, Ji L. Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells. Biochem Biophys Res Commun 410(2):235-41, 2011. e-Pub 2011. PMID: 21645495.
Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res 71(10):3658-68, 2011. e-Pub 2011. PMID: 21444672.
Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P. Genome-Wide Association Study of Survival in Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy. J Natl Cancer Inst 103(10):817-25, 2011. e-Pub 2011. PMID: 21483023.
Kim MP, Roth JA. Reply: Does Presence of Hematologic Maglignancy Change our Approach to Non-Small Cell Lung Cancer?. Ann Thorac Surg 9(15):1653, 2011.
Mehran R, Rice D, El-Zein R, Huang JL, Vaporciyan A, Goodyear A, Mehta A, Correa A, Walsh G, Roth J, Swisher S, Hofstetter W. Minimally invasive esophagectomy versus open esophagectomy, a symptom assessment study. Dis Esophagus 24(3):147-52, 2011. e-Pub 2010. PMID: 21040152.
Hemmati SH, Correa AM, Walsh GL, Swisher SG, Roth JA, Rice DC, Mehran RJ, Vaporciyan AA. The prognostic factors of chest wall metastasis resection. Eur J Cardiothorac Surg 40(2):328-333. e-Pub 2011. PMID: 21466960.
Stephens EH, Blackmon SH, Correa AM, Roth JA, Rice DC, Hofstetter W, Benjamin R, Mehran R, Swisher SG, Walsh GL, Vaporciyan AA. Progression after Chemotherapy Is a Novel Predictor of Poor Outcomes after Pulmonary Metastasectomy in Sarcoma Patients. J Am Coll Surg 5(12):1894-1904. e-Pub 2011. PMID: 21435923.
Stewart DJ, Behrens C, Roth J, Wistuba II. Exponential decay nonlinear regression analysis of patient survival curves: Preliminary assessment in non-small cell lung cancer. Lung Cancer 71(2):217-23, 2011. e-Pub 2010. PMID: 20627364.
Diao L, Clarke CH, Coombes KR, Hamilton SR, Roth J, Mao L, Czerniak B, Baggerly KA, Morris JS, Fung ET, Bast RC. Reproducibility of SELDI spectra across time and laboratories. Cancer Inform 10:45-64, 2011. e-Pub 2011. PMID: 21552492.
Singh SP, Han L, Murali R, Solis L, Roth J, Ji L, Wistuba I, Kundra V. SSTR2-based reporters for assessing gene transfer into non-small cell lung cancer: Evaluation using an intrathoracic mouse model. Hum Gene Ther 22(1):55-64, 2011. e-Pub 2010. PMID: 20653396.
Shanker M, Jin J, Branch CD, Miyamoto S, Grimm EA, Roth JA, Ramesh R. Tumor Suppressor Gene-Based Nanotherapy: From Test Tube to the Clinic. J Drug Deliv 2011:465845, 2011. e-Pub 2011. PMID: 21490751.
Dai J, Gu J, Lu C, Lin J, Stewart D, Chang D, Roth JA, Wu X. Genetic Variations in the Regulator of G-protein Signaling Genes Are Associated with Survival in Late-Stage Non-Small Cell Lung Cancer. PLoS One 6(6):e21120, 2011. e-Pub 2011. PMID: 21698121.
Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, Shanker M, Correa AM, Kondo S, Roth JA, Sokolov K, Ramesh R. EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. PLoS One 6(11):e25507, 2011. e-Pub 2011. PMID: 22087216.
Zandi R, Xu K, Poulsen HS, Roth JA, Ji L. The effect of adenovirus-mediated gene expression of FHIT in small cell lung cancer cells. Cancer Invest 29(10):683-91, 2011. PMID: 22085272.
Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Watson TJ, Swisher SG, M. D. Anderson Esophageal Cancer Group (Roth JA), University of Rochester School of Medicine and Dentistry Foregut Group. Endoscopic esophageal tumor length: a prognostic factor for patients with esophageal cancer. Cancer 117(1):63-9, 2011. e-Pub 2010. PMID: 20803613.
Nanjundan M, Byers LA, Carey MS, Siwak DR, Raso MG, Diao L, Wang J, Coombes KR, Roth JA, Mills GB, Wistuba II, Minna JD, Heymach JV. Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. J Thorac Oncol 5(12):1894-904, 2010. PMID: 21124077.
Pataer A, Raso MG, Correa AM, Behrens C, Tsuta K, Solis L, Fang B, Roth JA, Wistuba II, Swisher SG. Prognostic significance of RNA-dependent protein kinase (PKR) on non-small cell lung cancer patients. Clin Cancer Res 16(22):5522-8, 2010. e-Pub 2010. PMID: 20930042.
Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Vaporciyan AA, Watson TJ, Swisher SG, Members of the MD Anderson Esophageal Cancer Group (Roth JA) and the University of Rochester School of Medicine and Dentistry Foregut Group. A clinical nomogram predicting pathologic lymph-node involvement in esophageal cancer patients. Ann Surg 252(4):611-7, 2010. PMID: 20881767.
Swisher SG, Hofstetter W, Komaki R, Correa AM, Erasmus J, Lee JH, Liao Z, Maru D, Mehran R, Patel S, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Ajani JA. Improved long-term outcome with chemoradiotherapy strategies in esophageal cancer. Ann Thorac Surg 90(3):892-8; discussion 898-9, 2010. PMID: 20732514.
Kim MP, Correa AM, Lee J, Rice DC, Roth JA, Mehran RJ, Walsh GL, Ajani JA, Maru DM, Chang JY, Marom EM, Macapinlac HA, Lee JH, Vaporciyan AA, Rice T, Swisher SG, Hofstetter WL. Pathologic T0N1 esophageal cancer after neoadjuvant therapy and surgery: An orphan status. Ann Thorac Surg 90(3):884-90; discussion 890-1, 2010. PMID: 20732513.
Katz RL, He W, Khanna A, Fernandez RL, Zaidi TM, Krebs M, Caraway NP, Zhang HZ, Jiang F, Spitz MR, Blowers DP, Jimenez CA, Mehran RJ, Swisher SG, Roth JA, Morris JS, Etzel CJ, El-Zein R. Genetically abnormal circulating cells in lung cancer patients: An antigen-independent fluorescence in situ hybridization-based case-control study. Clin Cancer Res 16(15):3976-3987, 2010. e-Pub 2010. PMID: 20651054.
Kim MP, Correa AM, Swisher SG, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Erasmus J, Moran C, Vaporciyan AA, Roth JA. Non-small cell lung cancer resection in lymphoma patients. Ann Thorac Surg 90(1):210-216, 2010. PMID: 20609777.
Gaur P, Hofstetter WL, Bekele BN, Correa AM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Rice TW, Swisher SG. Comparison between established and the worldwide esophageal cancer collaboration staging systems. Ann Thorac Surg 89(6):1797-1804.e3, 2010. PMID: 20494031.
Shanker M, Wilcutts D, Roth JA, Ramesh R. Drug resistance in lung cancer. Lung cancer: targets and therapy (Dove Press) 1:23-26, 2010.
Gjetting T, Arildsen NS, Christensen CL, Poulsen TT, Roth JA, Handlos VN, Poulsen HS. In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol mediated gene transfection. Int J Nanomedicine 5:371-3, 2010. e-Pub 2010. PMID: 20957159.
Tsao AS, Roth JA, Herbst RS. Surgery: Future directions in multimodality therapy for NSCLC. Nat Rev Clin Oncol 7(1):10-2, 2010. PMID: 20029443.
Meng J, Fang B, Liao Y, Chresta CM, Smith PD, Roth JA. Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim. PLoS One 5(9):e13026, 2010. e-Pub 2010. PMID: 20885957.
Hildebrandt MA, Komaki R, Liao Z, Gu J, Chang JY, Ye Y, Lu C, Stewart DJ, Minna JD, Roth JA, Lippman SM, Cox JD, Hong WK, Spitz MR, Wu X. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. PLoS One 5(8):e12402, 2010. e-Pub 2010. PMID: 20811626.
Jayachandran G, Ueda K, Wang B, Roth JA, Ji L. NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. PLoS One 5(8):1-12, 2010. e-Pub 2010. PMID: 20700484.
Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, Peng Z, Herbst RS, Papadimitrakopoulou V, Minna JD, Peyton M, Roth JA. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One 5(11):e14124, 2010. e-Pub 2010. PMID: 21124782.
Nemunaitis J, Clayman G, Agarwala SS, Hrushesky W, Wells JR, Moore C, Hamm J, Yoo G, Baselga J, Murphy BA, Menander KA, Licato LL, Chada S, Gibbons RD, Olivier M, Hainaut P, Roth JA, Sobol RE, Goodwin WJ. Biomarkers predict p53 gene therapy efficacy in recurrent, squamous cell carcinoma of the head and neck. Clin Cancer Res 15(24):7719-7725, 2009. e-Pub 2009. PMID: 19996201.
Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA. High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol Ther 8(21):2073-80, 2009. e-Pub 2009. PMID: 19783898.
Braiteh F, Correa AM, Hofstetter WL, Rice DC, Vaporciyan AA, Walsh GL, Roth JA, Mehran RJ, Swisher SG, Ajani JA. Association of age and survival in patients with gastroesophageal cancer undergoing surgery with or without preoperative therapy. Cancer 115(19):4450-8, 2009. e-Pub 2009. PMID: 19562780.
Bolton WD, Hofstetter WL, Francis AM, Correa AM, Ajani JA, Bhutani MS, Erasmus J, Komaki R, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Swisher SG. Impact of tumor length on long-term survival of pT1 esophageal adenocarcinoma. J Thorac Cardiovasc Surg 138(4):831-6, 2009. e-Pub 2009. PMID: 19660349.
William WN, Lin HY, Lee JJ, Lippman SM, Roth JA, Kim ES. Re-visiting stage IIIB and IV non-small cell lung cancer: analysis of the surveillance, epidemiology and end results data. Chest 136(3):701-9, 2009. e-Pub 2009. PMID: 19318668.
Blackmon SH, Shah N, Roth JA, Correa AM, Vaporciyan AA, Rice DC, Hofstetter W, Walsh GL, Benjamin R, Pollock R, Swisher SG, Mehran R. Resection of pulmonary and extrapulmonary sarcomatous metastases is associated with long-term survival. Ann Thorac Surg 88(3):877-84; discussion 884-5, 2009. PMID: 19699915.
Kassis ES, Vaporciyan AA, Swisher SG, Correa AM, Bekele BN, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Moran CA, Pisters KM, Rice DC, Walsh GL, Roth JA. Application of the revised lung cancer staging system (IASLC Staging Project) to a cancer center population. J Thorac Cardiovasc Surg 138(2):412-418.e1-2, 2009. e-Pub 2009. PMID: 19619787.
Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba II, Ji L, Roth JA, Minna JD, Pertsemlidis A. miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol Cancer Res 7(8):1234-43, 2009. e-Pub 2009. PMID: 19671678.
Bolton WD, Rice DC, Correa AM, Hofstetter W, Komaki R, Mehran R, Pisters K, Roth JA, Vaporciyan AA, Walsh GL, Swisher SG. Influence of age on choice of therapy and surgical outcomes in patients with non-small cell lung cancer. Am Surg 75(7):598-603; discussion 603-4, 2009. PMID: 19655604.
Bolton WD, Rice DC, Goodyear A, Correa AM, Erasmus J, Hofstetter W, Komaki R, Mehran R, Pisters K, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Weaver J, Rhines L. Superior sulcus tumors with vertebral body involvement: a multimodality approach. J Thorac Cardiovasc Surg 137(6):1379-87, 2009. PMID: 19464452.
Tsao AS, Wistuba I, Roth JA, Kindler HL. Malignant pleural mesothelioma. J Clin Oncol 27(12):2081-90, 2009. e-Pub 2009. PMID: 19255316.
Yendamuri S, Swisher SG, Correa AM, Hofstetter W, Ajani JA, Francis A, Maru D, Mehran RJ, Rice DC, Roth JA, Walsh GL, Vaporciyan AA. Esophageal tumor length is independently associated with long-term survival. Cancer 115(3):508-16, 2009. PMID: 19117343.
Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn PG. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther 8(3):241-248, 2009. e-Pub 2009. PMID: 19106640.
Tsao AS, Mehran R, Roth JA. Neoadjuvant and intra-pleural therapies for malignant pleural mesothelioma. Clin Lung Cancer 10(1):36-41, 2009. PMID: 19289370.
Ivanova AV, Ivanov SV, Prudkin L, Nonaka D, Liu Z, Tsao A, Wistuba I, Roth J, Pass HI. Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects. Mol Cancer 8:91, 2009. PMID: 19852844.
Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA, Komaki R. Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 72(4):967-71, 2008. PMID: 18954709.
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455(7216):1069-75, 2008. PMID: 18948947.
Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res 68(18):7448-56, 2008. PMID: 18794132.
Yendamuri S, Vaporciyan AA, Zaidi T, Feng L, Fernandez R, Bekele NB, Hofstetter WL, Jiang F, Mehran RJ, Rice DC, Spitz MR, Swisher SG, Walsh GL, Roth JA, Katz RL. 3p22.1 and 10q22.3 deletions detected by fluorescence in situ hybridization (FISH): a potential new tool for early detection of non-small cell lung Cancer (NSCLC). J Thorac Oncol 3(9):979-84, 2008. PMID: 18758299.
Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Mol Cancer Ther 7(8):2528-35, 2008. PMID: 18723497.
Prudkin L, Behrens C, Liu DD, Zhou X, Ozburn NC, Bekele BN, Minna JD, Moran C, Roth JA, Ji L, Wistuba II. Loss and reduction of Fus1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. Clin Cancer Res 14(1):41-47, 2008. PMID: 18172250.
Deng WG, Wu G, Ueda K, Xu K, Roth JA, Ji L. Enhancement of antitumor activity of cisplatin in human lung cancer cells by tumor suppressor FUS1. Cancer Gene Ther 15(1):29-39, 2008. PMID: 17828283.
Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG. Development of Ad-mda7/IL-24-resistant lung cancer cell lines. Cancer Biol Ther 7(1):103-8, 2008. PMID: 18059175.
Katz RL, Zaidi TM, Fernandez RL, Zhang J, He W, Acosta C, Daniely M, Madi L, Vargas MA, Dong Q, Jiang XG, Caraway NP, Vaporciyan AA, Roth JA, Spitz MR. Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancer. Mod Pathol 21:950-60, 2008. e-Pub 2008. PMID: 18500269.
Deus HF, Stanislaus R, Veiga DF, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Chang A, Vogel LH, Almeida JS. A semantic web management model for integrative biomedical informatics. PLoS One 3(8):e2946, 2008. e-Pub 2008. PMID: 18698353.
Deus HF, Stanislaus R, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Almeida JS. Data driven semantic integration of translational lung cancer research at MDAnderson Cancer Center. AMIA Annu Symp Proc:927, 2008. e-Pub 2008. PMID: 18999102.
Jayachandran G, Sazaki J, Nishizaki M, Xu K, Girard L, Minna JD, Roth JA, Ji L. Fragile Histidine Triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch. Cancer Res 67(21):10379-88, 2007. PMID: 17974981.
Yendamuri S, Komaki RR, Correa AM, Allen P, Wynn B, Blackmon S, Hofstetter WL, Rice DC, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Mehran RJ. Comparison of limited surgery and three-dimensional conformal radiation in high-risk patients with stage I non-small cell lung cancer. J Thorac Oncol 2(11):1022-8, 2007. PMID: 17975494.
Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, Ibarguen H, Morice RC, Walsh G, Roth JA, Minna J, Ro JY, Broxson A, Hong WK, Lee JJ. Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. J Natl Cancer Inst 99(21):1603-12, 2007. PMID: 17971525.
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M. Characterizing the cancer genome in lung adenocarcinoma. Nature 450(7171):893-8. e-Pub 2007. PMID: 17982442.
Rice DC, Stevens CW, Correa AM, Vaporciyan AA, Tsao A, Forster KM, Walsh GL, Swisher SG, Hofstetter WL, Mehran RJ, Roth JA, Liao Z, Smythe WR. Outcomes after extrapleural pneumonectomy and intensity-modulated radiation therapy for malignant pleural mesothelioma. Ann Thorac Surg 84(5):1685-92; discussion 1692-3, 2007. PMID: 17954086.
Lin J, Sun T, Ji L, Deng W, Roth J, Minna J, Arlinghaus R. Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene 26(49):6989-96, 2007. e-Pub 2007. PMID: 17486070.
von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor κB and Akt activation. Clin Cancer Res 13(20):6032-9, 2007. PMID: 17947465.
Martin LW, Correa AM, Ordonez NG, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC. Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg 84(3):973-80, 2007. PMID: 17720411.
Bakaeen F, Rice D, Correa AM, Walsh GL, Vaporciyan AA, Putnam JB, Swisher SG, Roth JA, Huh J, Chu D, Smythe WR. Use of aprotinin in extrapleural pneumonectomy: effect on hemostasis and incidence of complications. Ann Thorac Surg 84(3):982-6, 2007. PMID: 17720413.
Deng WG, Jayachandran G, Wu G, Xu K, Roth JA, Ji L. Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells. J Biol Chem 282(36):26460-70, 2007. e-Pub 2007. PMID: 17630431.
Hofstetter W, Correa AM, Bekele N, Ajani JA, Phan A, Komaki RR, Liao Z, Maru D, Wu TT, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Francis A, Blackmon S, Swisher SG. Proposed modification of nodal status in AJCC esophageal cancer staging system. Ann Thorac Surg 84(2):365-73; discussion 374-5, 2007. PMID: 17643602.
Kelsen DP, Winter KA, Gunderson LL, Mortimer J, Estes NC, Haller DG, Ajani JA, Kocha W, Minsky BD, Roth JA, Willett CG; Radiation Therapy Oncology Group; USA Intergroup. Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer. J Clin Oncol 25(24):3719-25, 2007. PMID: 17704421.
Ohtani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, Kondo S, Atkinson EN, Minna JD, Roth JA, Ji L. Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy. Cancer Res 67(13):6293-303, 2007. PMID: 17616688.
Blackmon SH, Correa AM, Wynn B, Hofstetter WL, Martin LW, Mehran RJ, Rice DC, Swisher SG, Walsh GL, Roth JA, Vaporciyan AA. Propensity-matched analysis of three techniques for intrathoracic esophagogastric anastomosis. Ann Thorac Surg 83(5):1805-13; discussion 1813, 2007. PMID: 17462404.
Deng WG, Nishizaki M, Fang B, Roth JA, Ji L. Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Biochem Biophys Res Commun 355(4):993-99, 2007. e-Pub 2007. PMID: 17328863.
Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG. Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. Cancer Gene Ther 14(1):12-18, 2007. PMID: 17024233.
Deng WG, Kawashima H, Wu G, Jayachandran G, Xu K, Minna JD, Roth JA, Ji L. Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells. Cancer Res 67(2):709-17, 2007. PMID: 17234782.
Elayadi AN, Samli KN, Prudkin L, Liu YH, Bian A, Xie XJ, Wistuba II, Roth JA, McGuire MJ, Brown KC. A peptide selected by biopanning identifies integrin αγβ6 as a prognostic biomarker for non small cell lung cancer. Cancer Res 67:5889-5895, 2007.
Gu J, Berman D, Lu C, Wistuba II, Roth JA, Frazier M, Spitz MR, Wu X. Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12(24):7329-38, 2006. PMID: 17189404.
Herrera LJ, Correa AM, Vaporciyan AA, Hofstetter WL, Rice DC, Swisher SG, Walsh GL, Roth JA, Mehran RJ. Increased risk of aspiration and pulmonary complications after lung resection in head and neck cancer patients. Ann Thorac Surg 82(6):1982-7; discussion 1987-8, 2006. PMID: 17126095.
Hamada K, Shirakawa T, Gotoh A, Roth JA, Follen M.. Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer. Gynecol Oncol 103:820-30, 2006. PMID: 16908054.
Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L. The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells. Cancer Res 66(19):9682-90, 2006. PMID: 17018626.
Malaisrie SC, Hofstetter WL, Correa AM, Ajani JA, Komaki RR, Rice DC, Vaporciyan AA, Walsh GL, Roth JA, Wu TT, Swisher SG. The addition of induction chemotherapy to preoperative, concurrent chemoradiotherapy improves tumor response in patients with esophageal adenocarcinoma. Cancer 107:967-74, 2006. PMID: 16874819.
Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK. Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Ther 13(8):806-14, 2006. PMID: 16628227.
Peng HH, Wu S, Davis JJ, Wang L, Roth JA, Marini FC, Fang B. A rapid and efficient method for purification of recombinant adenovirus with arginine-glycine-aspartic acid-modified fibers. Anal Biochem 354(1):140-7, 2006. PMID: 16707084.
Liao Z, Liu H, Swisher SG, Wang L, Wu TT, Correa AM, Roth JA, Cox JD, Komaki R, Ajani JA, Wei Q. Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation. Int J Radiat Oncol Biol Phys 64(3):700-8, 2006. PMID: 16242255.
Rohatgi PR, Swisher SG, Correa AM, Wu TT, Liao Z, Komaki R, Walsh GL, Vaporciyan AA, Rice DC, Bresalier RS, Roth JA, Ajani JA. Histologic subtypes as determinants of outcome in esophageal carcinoma patients with pathologic complete response after preoperative chemoradiotherapy. Cancer 106(3):552-8, 2006. PMID: 16353210.
Tsao AS, Tang XM, Sabloff B, Xiao L, Shigematsu H, Roth J, Spitz M, Hong WK, Gazdar A, Wistuba I. Defining clinical-pathological characteristics of the EGFR gene mutation in non-small cell lung cancer. J Thorac Oncol 1:231-39, 2006.
Guo W, Zhu H, Zhang L, Davis J, Teraishi F, Roth JA, Stephens C, Fueyo J, Jiang H, Conrad C, Fang B. Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models. Cancer Gene Ther 13:82-90, 2006. PMID: 16037823.
Malaisrie SC, Hofstetter WL, Correa AM, Ajani JA, Komaki RR, Liao Z, Phan A, Rice DC, Vaporciyan AA, Walsh GL, Lahoti S, Lee JH, Bresalier R, Roth JA, Swisher SG. Endoscopic ultrasonography-identified celiac adenopathy remains a poor prognostic factor despite preoperative chemoradiotherapy in esophageal adenocarcinoma. J Thorac Cardiovasc Surg 131(1):65-72, 2006. PMID: 16399296.
Rohatgi PR, Correa AM, Swisher SG, Wu TT, Liao Z, Komaki R, Walsh GL, Vaporciyan AA, Lee JH, Rice DC, Roth JA, Ajani JA. Gender-based analysis of esophageal cancer patients undergoing preoperative chemoradiation: differences in presentation and therapy outcome. Dis Esophagus 19:152-7, 2006. PMID: 16722991.
Roth JA. Adenovirus p53 gene therapy. Expert Opin Biol Ther 6(1):55-61, 2006. PMID: 16370914.
Hamada K, Sakaue M, Sarkar A, Buchl S, Satterfield W, Keeling M, Sastry J, Roth JA, Follen M. Immune responses to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide. Gynecol Oncol 99(3 Suppl 1):S177-86, 2005. PMID: 16214207.
Hamada K, Ueda N, Ito M, Roth JA, Follen M. The nude rat as an orthotopic model for cervical cancer. Gynecol Oncol 99(3 Suppl 1):S159-65, 2005. PMID: 16185752.
Martin LW, Correa AM, Hofstetter W, Hong WK, Komaki R, Putnam JB, Jr, Rice DC, Smythe WR, Swisher SG, Vaporciyan AA, Walsh GL, Roth JA. The evolution of treatment outcomes for resected stage IIIA non-small cell lung cancer over 16 years at a single institution. J Thorac Cardiovasc Surg 130(6):1601-10, 2005. PMID: 16308005.
Rohatgi P, Swisher SG, Correa AM, Wu TT, Liao Z, Komaki R, Walsh GL, Vaporciyan AA, Rice DC, Roth JA, Ajani JA. Characterization of pathologic complete response after preoperative chemoradiotherapy in carcinoma of the esophagus and outcome after pathologic complete response. Cancer 104(11):2365-72, 2005. PMID: 16245310.
Rohatgi PR, Swisher SG, Correa AM, Wu TT, Liao Z, Komaki R, Walsh G, Vaporciyan A, Lynch PM, Rice DC, Roth JA, Ajani JA. Failure patterns correlate with the proportion of residual carcinoma after preoperative chemoradiotherapy for carcinoma of the esophagus. Cancer 104(7):1349-55, 2005. PMID: 16130133.
Martin LW, Swisher SG, Hofstetter W, Correa AM, Mehran RJ, Rice DC, Vaporciyan AA, Walsh GL, Roth JA. Intrathoracic leaks following esophagectomy are no longer associated with increased mortality. Ann Surg 242(3):392-9; discussion 399-402, 2005. PMID: 16135925.
Tang X, Shigematsu H, Bekele BN, Roth JA, Minna JD, Hong WK, Gazdar AF, Wistuba II. EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res 65(17):7568-72, 2005. PMID: 16140919.
Agarwal B, Swisher SG, Ajani J, Kelly K, Komaki RR, Abu-Hamda E, Correa AM, Roth JA. Differential response to preoperative chemoradiation and surgery in esophageal adenocarcinomas based on presence of Barrett's esophagus and symptomatic gastroesophageal reflux. Ann Thorac Surg 79(5):1716-23, 2005. PMID: 15854962.
Pataer A, Vorburger SA, Chada S, Balachandran S, Barber GN, Roth JA, Hunt KK, Swisher SG. Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR. Mol Ther 11(5):717-23, 2005. PMID: 15851010.
Swisher SG, Hofstetter W, Wu TT, Correa AM, Ajani JA, Komaki RR, Chirieac L, Hunt KK, Liao Z, Phan A, Rice DC, Vaporciyan AA, Walsh GL, Roth JA. Proposed revision of the esophageal cancer staging system to accommodate pathologic response (pP) following preoperative chemoradiation (CRT). Ann Surg 241(5):810-7; discussion 817-20, 2005. PMID: 15849517.
Chirieac LR, Swisher SG, Ajani JA, Komaki RR, Correa AM, Morris JS, Roth JA, Rashid A, Hamilton SR, Wu TT. Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation. Cancer 103(7):1347-55, 2005. PMID: 15719440.
Saito Y, Miyahara R, Gopalan B, Litvak A, Inoue S, Shanker M, Branch CD, Mhashilkar AM, Roth JA, Chada S, Ramesh R. Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated -7 (mda-7)/interleukin-24 (IL-24) gene. Cancer Gene Ther 12(3):238-47, 2005. PMID: 15578066.
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339-46, 2005. PMID: 15741570.
Oida Y, Gopalan B, Miyahara R, Inoue S, Branch CD, Mhashilkar AM, Lin E, Bekele BN, Roth JA, Chada S, Ramesh R. Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther 4(2):291-304, 2005. PMID: 15713900.
Rice DC, Correa AM, Vaporciyan AA, Sodhi N, Smythe WR, Swisher SG, Walsh GL, Putnam JB, Komaki R, Ajani JA, Roth JA. Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity. Ann Thorac Surg 79(2):391-7; discussion 391-7, 2005. PMID: 15680801.
Sasaki R, Komaki R, Macapinlac H, Erasmus J, Allen P, Forster K, Putnam JB, Herbst RS, Moran CA, Podoloff DA, Roth JA, Cox JD. [18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer. J Clin Oncol 23(6):1136-43, 2005. PMID: 15718309.
Rohatgi PR, Swisher SG, Correa AM, Wu TT, Liao Z, Walsh GL, Vaporciyan AA, Rice DC, Fukami N, Roth JA, Ajani JA. Comparison of clinical stage, therapy response, and patient outcome between squamous cell carcinoma and adenocarcinoma of the esophagus. Int J Gastrointest Cancer 36(2):69-76, 2005. PMID: 16648656.
Wu X, Roth JA, Zhao H, Luo S, Zheng YL, Chiang S, Spitz MR. Cell cycle checkpoints, DNA damage/repair, and lung cancer risk. Cancer Res 65(1):349-57, 2005. PMID: 15665313.
Ascioti AJ, Hofstetter WL, Miller MJ, Rice DC, Swisher SG, Vaporciyan AA, Roth JA, Putnam JB, Smythe WR, Feig BW, Mansfield PF, Pisters PW, Torres MT, Walsh GL. Long-segment, supercharged, pedicled jejunal flap for total esophageal reconstruction. J Thorac Cardiovasc Surg 130(5):1391-98, 2005. PMID: 16256794.
Liao Z, Zhang Z, Jin J, Ajani JA, Swisher SG, Stevens CW, Ho L, Smythe R, Vaporciyan AA, Putnam JB, Walsh GL, Roth JA, Yao JC, Allen PK, Cox JD, Komaki R. Esophagectomy after concurrent chemoradiotherapy improves locoregional control in clinical stage II or III esophageal cancer patients. Int J Radiat Oncol Biol Phys 60(5):1484-93, 2004. PMID: 15590179.
Ramesh R, Ito I, Saito Y, Wu Z, Mhashikar AM, Wilson DR, Branch CD, Roth JA, Chada S. Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery. DNA Cell Biol 23(12):850-7, 2004. PMID: 15684712.
Ito I, Ji L, Tanaka F, Saito Y, Gopalan B, Branch CD, Xu K, Atkinson EN, Bekele BN, Stephens LC, Minna JD, Roth JA, Ramesh R. Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo. Cancer Gene Ther 11(11):733-9, 2004. PMID: 15486560.
Swisher SG, Erasmus J, Maish M, Correa AM, Macapinlac H, Ajani JA, Cox JD, Komaki RR, Hong D, Lee HK, Putnam JB, Rice DC, Smythe WR, Thai L, Vaporciyan AA, Walsh GL, Wu TT, Roth JA. 2-Fluoro-2-deoxy-D-glucose positron emission tomography imaging is predictive of pathologic response and survival after preoperative chemoradiation in patients with esophageal carcinoma. Cancer 101(8):1776-85, 2004. PMID: 15386332.
Swisher SG, Maish M, Erasmus JJ, Correa AM, Ajani JA, Bresalier R, Komaki R, Macapinlac H, Munden RF, Putnam JB, Rice D, Smythe WR, Vaporciyan AA, Walsh GL, Wu TT, Roth JA. Utility of PET, CT, and EUS to identify pathologic responders in esophageal cancer. Ann Thorac Surg 78(4):1152-60; discussion 1152-60, 2004. PMID: 15464463.
Gomyo Y, Sasaki J, Branch C, Roth JA, Mukhopadhyay T. 5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells. Oncogene 23(40):6779-87, 2004. PMID: 15273730.
Nishizaki M, Sasaki J, Fang B, Atkinson EN, Minna JD, Roth JA, Ji L. Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells. Cancer Res 64(16):5745-52, 2004. PMID: 15313915.
Agarwal B, Swisher S, Ajani J, Kelly K, Fanning C, Komaki RR, Putnam JB, Jr, Abu-Hamda E, Molke KL, Walsh GL, Correa AM, Ho L, Liao Z, Lynch PM, Rice DC, Smythe WR, Stevens CW, Vaporciyan AA, Yao J, Roth JA. Endoscopic ultrasound after preoperative chemoradiation can help identify patients who benefit maximally after surgical esophageal resection. Am J Gastroenterol 99(7):1258-66, 2004. PMID: 15233663.
Wu TT, Chirieac LR, Swisher SG, Komaki RU, Correa AM, Roth J, Rashid A, Hamilton SR, Ajani JA. Post-chemoradiation surgical pathologic stage accurately predicts outcome of patients with esophageal or gastroesophageal junction carcinoma. J Clin Oncol 22(14_suppl):4028, 2004. PMID: 28016401.
Ajani JA, Walsh G, Komaki R, Morris J, Swisher SG, Putnam JB, Lynch PM, Wu TT, Smythe R, Vaporciyan A, Faust J, Cohen DS, Nivers R, Roth JA. Preoperative induction of CPT-11 and cisplatin chemotherapy followed by chemoradiotherapy in patients with locoregional carcinoma of the esophagus or gastroesophageal junction. Cancer 100(11):2347-54, 2004. PMID: 15160337.
Chada S, Sutton RB, Ekmekcioglu S, Ellerhorst J, Mumm JB, Leitner WW, Yang HY, Sahin AA, Hunt KK, Fuson KL, Poindexter N, Roth JA, Ramesh R, Grimm EA, Mhashilkar AM. MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family. Int Immunopharmacol 4(5):649-67, 2004. PMID: 15120650.
Uno F, Sasaki J, Nishizaki M, Carboni G, Xu K, Atkinson EN, Kondo M, Minna JD, Roth JA, Ji L. Myristoylation of the Fus1 protein is required for tumor suppression in human lung cancer cells. Cancer Res 64(9):2969-76, 2004. PMID: 15126327.
Honda T, Coppola S, Ghibelli L, Cho SH, Kagawa S, Spurgers KB, Brisbay SM, Roth JA, Meyn RE, Fang B, McDonnell TJ. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Cancer Gene Ther 11(4):249-55, 2004. PMID: 15002033.
Tsunemitsu Y, Kagawa S, Tokunaga N, Otani S, Umeoka T, Roth JA, Fang B, Tanaka N, Fujiwara T. Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer. Gut 53(4):554-60, 2004. PMID: 15016751.
Ito I, Saeki T, Mohuiddin I, Saito Y, Branch CD, Vaporciyan A, Roth JA, Ramesh R. Persistent transgene expression following intravenous administration of a liposomal complex: role of interleukin-10-mediated immune suppression. Mol Ther 9(3):318-27, 2004. PMID: 15006598.
Vaporciyan AA, Correa AM, Rice DC, Roth JA, Smythe WR, Swisher SG, Walsh GL, Putnam JB. Risk factors associated with atrial fibrillation after noncardiac thoracic surgery: analysis of 2588 patients. J Thorac Cardiovasc Surg 127(3):779-86, 2004. PMID: 15001907.
Gu J, Zhang L, Swisher SG, Liu J, Roth JA, Fang B. Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis. Oncogene 23(6):1300-7, 2004. PMID: 14676844.
Jin J, Liao Z, Zhang Z, Ajani J, Swisher S, Chang JY, Jeter M, Guerrero T, Stevens CW, Vaporciyan A, Putnam J Jr, Walsh G, Smythe R, Roth J, Yao J, Allen P, Cox JD, Komaki R. Induction chemotherapy improved outcomes of patients with respectable esophageal cancer who received chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 60:427-436, 2004.
Ohtani S, Kagawa S, Tango Y, Umeoka T, Tokunaga N, Tsunemitsu Y, Roth JA, Taya Y, Tanaka N, Fujiwara T. Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo. Mol Cancer Ther 3(1):93-100, 2004. PMID: 14749479.
Yang Q, Cleary KR, Yao JC, Swisher SG, Roth JA, Lynch PM, Komaki R, Ajani JA, Rashid A, Hamilton SR, Wu TT. Significance of post-chemoradiation biopsy in predicting residual esophageal carcinoma in the surgical specimen. Dis Esophagus 17(1):38-43, 2004. PMID: 15209739.
Gopalan B, Ito I, Branch CD, Stephens C, Roth JA, Ramesh R. Nanoparticle based systemic gene therapy for lung cancer: molecular mechanisms and strategies to suppress nanoparticle-mediated inflammatory response. Technol Cancer Res Treat 3(6):647-567, 2004. PMID: 15560723.
Taylor NA, Liao ZX, Cox JD, Stevens C, Roth J, Walsh G, Chang JY, Guerrero T, Jeter M, Putnam J, Fossella FV, Allen P, Komaki R. Equivalent outcome of patients with clinical Stage IIIA non-small-cell lung cancer treated with concurrent chemoradiation compared with induction chemotherapy followed by surgical resection. Int J Radiat Oncol Biol Phys 58(1):204-12, 2004. PMID: 14697440.
Lee HK, Vaporciyan AA, Cox JD, Tucker SL, Putnam JB, Ajani JA, Liao Z, Swisher SG, Roth JA, Smythe WR, Walsh GL, Mohan R, Liu HH, Mooring D, Komaki R. Postoperative pulmonary complications after preoperative chemoradiation for esophageal carcinoma: correlation with pulmonary dose-volume histogram parameters. Int J Radiat Oncol Biol Phys 57(5):1317-22, 2003. PMID: 14630268.
Sah NK, Munshi A, Nishikawa T, Mukhopadhyay T, Roth JA, Meyn RE. Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity. Mol Cancer Ther 2(11):1223-31, 2003. PMID: 14617796.
Saito Y, Gopalan B, Mhashilkar AM, Roth JA, Chada S, Zumstein L, Ramesh R. Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. Cancer Gene Ther 10(11):803-13, 2003. PMID: 14605666.
Virmani A, Rathi A, Heda S, Sugio K, Lewis C, Tonk V, Takahashi T, Roth JA, Minna JD, Euhus DM, Gazdar AF. Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers. Int J Cancer 107(3):341-5, 2003. PMID: 14506731.
Rice D, Kim HW, Sabichi A, Lippman S, Lee JJ, Williams B, Vaporciyan A, Smythe WR, Swisher S, Walsh G, Putnam JB, Hong WK, Roth J. The risk of second primary tumors after resection of stage I nonsmall cell lung cancer. Ann Thorac Surg 76(4):1001-7; discussion 1007-8, 2003. PMID: 14529975.
Lin T, Zhang L, Davis J, Gu J, Nishizaki M, Ji L, Roth JA, Xiong M, Fang B. Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers. Mol Ther 8(3):441-8, 2003. PMID: 12946317.
Swisher SG, Ajani JA, Komaki R, Nesbitt JC, Correa AM, Cox JD, Lahoti S, Martin F, Putnam JB, Smythe WR, Vaporciyan AA, Walsh GL, Roth JA. Long-term outcome of phase II trial evaluating chemotherapy, chemoradiotherapy, and surgery for locoregionally advanced esophageal cancer. Int J Radiat Oncol Biol Phys 57(1):120-7, 2003. PMID: 12909224.
Ajani JA, Faust J, Yao J, Komaki R, Stevens C, Swisher S, Putnam JB, Vaporciyan A, Smythe R, Walsh G, Rice D, Roth J. Irinotecan/cisplatin followed by 5-FU/paclitaxel/radiotherapy and surgery in esophageal cancer. Oncology (Williston Park) 17(9 Suppl 8):20-2, 2003. PMID: 14569843.
Mhashilkar AM, Stewart AL, Sieger K, Yang HY, Khimani AH, Ito I, Saito Y, Hunt KK, Grimm EA, Roth JA, Meyn RE, Ramesh R, Chada S. MDA-7 negatively regulates the β-catenin and PI3K signaling pathways in breast and lung tumor cells. Mol Ther 8(2):207-19, 2003. PMID: 12907143.
Virmani A, Rathi A, Sugio K, Sathyanarayana UG, Toyooka S, Kischel FC, Tonk V, Padar A, Takahashi T, Roth JA, Euhus DM, Minna JD, Gazdar AF. Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer. Int J Cancer 106(2):198-204, 2003. PMID: 12800194.
Fang B, Roth JA. Tumor-suppressing gene therapy. Cancer Biol Ther 2(4 Suppl 1):S115-21, 2003. PMID: 14508088.
Taylor NA, Liao ZX, Stevens C, Walsh G, Roth J, Putnam J, Fossella F, Allen P, Cox JD, Komaki R. Postoperative radiotherapy increases locoregional control of patients with stage IIIA non-small-cell lung cancer treated with induction chemotherapy followed by surgery. Int J Radiat Oncol Biol Phys 56(3):616-25, 2003. PMID: 12788166.
Huang X, Lin T, Gu J, Zhang L, Roth JA, Liu J, Fang B. Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene. Int J Oncol 22(6):1241-5, 2003. PMID: 12738989.
Pataer A, Chada S, Hunt KK, Roth JA, Swisher SG. Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release. J Thorac Cardiovasc Surg 125(6):1328-35, 2003. PMID: 12830052.
Ito I, Gopalan B, Mohiuddin I, Saeki T, Saito Y, Branch CD, Vaporciyan A, Stephens LC, Yen N, Roth JA, Ramesh R. Increased uptake of liposomal-DNA complexes by lung metastases following intravenous administration. Mol Ther 7:409-18, 2003. PMID: 12668137.
Milas I, Komaki R, Hachiya T, Bubb RS, Ro JY, Langford L, Sawaya R, Putnam JB, Allen P, Cox JD, McDonnell TJ, Brock W, Hong WK, Roth JA, Milas L. Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. Clin Cancer Res 9(3):1070-6, 2003. PMID: 12631609.
Kurie JM, Lotan R, Lee JJ, Lee JS, Morice RC, Liu DD, Xu XC, Khuri FR, Ro JY, Hittelman WN, Walsh GL, Roth JA, Minna JD, Hong WK. Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-β expression in the bronchial epithelium: results from a randomized placebo-controlled trial. J Natl Cancer Inst 95(3):206-14, 2003. PMID: 12569142.
Carboni GL, Gao B, Nishizaki M, Xu K, Minna JD, Roth JA, Ji L. CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Oncogene 22(4):615-26, 2003. PMID: 12555074.
Swisher SG, Roth JA, Komaki R, Gu J, Lee JJ, Hicks M, Ro JY, Hong WK, Merritt JA, Ahrar K, Atkinson NE, Correa AM, Dolormente M, Dreiling L, El-Naggar AK, Fossella F, Francisco R, Glisson B, Grammer S, Herbst R, Huaringa A, Kemp B, Khuri FR, Kurie JM, Liao Z, McDonnell TJ, Morice R, Morello F, Munden R, Papadimitrakopoulou V, Pisters KM, Putnam JB, Sarabia AJ, Shelton T, Stevens C, Shin DM, Smythe WR, Vaporciyan AA, Walsh GL, Yin M. Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res 9(1):93-101, 2003. PMID: 12538456.
Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, Fukuyama Y, Virmani AK, Zochbauer-Muller S, Tsukuda K, Sugio K, Shimizu N, Shimizu K, Lee H, Chen CY, Fong KM, Gilcrease M, Roth JA, Minna JD, Gazdar AF. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 103(2):153-60, 2003. PMID: 12455028.
Munden RG, Truong MT, Swisher SG, Gupta S, Hicks ME, Merritt JA, Roth JA. CT evaluation of non-small cell lung cancer undergoing gene therapy with adenoviral p53 Gene Therapy. Internet J. Radiol 3:52-59, 2003.
Brose MS, Volpe P, Feldman M, Kumar M, Rishi I, Gerrero R, Einhorn E, Herlyn M, Minna J, Nicholson A, Roth JA, Albelda SM, Davies H, Cox C, Brignell G, Stephens P, Futreal PA, Wooster R, Stratton MR, Weber BL. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62(23):6997-7000, 2002. PMID: 12460918.
Kawabe S, Nishikawa T, Munshi A, Roth JA, Chada S, Meyn RE. Adenovirus-mediated mda-7 gene expression radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms. Mol Ther 6(5):637-44, 2002. PMID: 12409262.
Lin T, Huang X, Gu J, Zhang L, Roth JA, Xiong M, Curley SA, Yu Y, Hunt KK, Fang B. Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells. Oncogene 21(52):8020-8, 2002. PMID: 12439752.
Sasaki J, Ramesh R, Chada S, Gomyo Y, Roth JA, Mukhopadhyay T. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther 1(13):1201-9, 2002. PMID: 12479701.
Huang X, Lin T, Gu J, Zhang L, Roth JA, Stephens LC, Yu Y, Liu J, Fang B. Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. Gene Ther 9(20):1379-86, 2002. PMID: 12365003.
Hofstetter W, Swisher SG, Correa AM, Hess K, Putnam JB, Ajani JA, Dolormente M, Francisco R, Komaki RR, Lara A, Martin F, Rice DC, Sarabia AJ, Smythe WR, Vaporciyan AA, Walsh GL, Roth JA. Treatment outcomes of resected esophageal cancer. Ann Surg 236(3):376-84; discussion 384-5, 2002. PMID: 12192324.
Mukhopadhyay T, Sasaki J, Ramesh R, Roth JA. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Clin Cancer Res 8(9):2963-9, 2002. PMID: 12231542.
Zhang L, Gu J, Lin T, Huang X, Roth JA, Fang B. Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. Gene Ther 9(18):1262-70, 2002. PMID: 12215894.
Bubb RS, Komaki R, Hachiya T, Milas I, Ro JY, Langford L, Sawaya R, Putnam JB, Allen P, Cox JD, McDonnell TJ, Brock W, Hong WK, Roth JA, Milas L. Association of Ki-67, p53, and bcl-2 expression of the primary non-small-cell lung cancer lesion with brain metastatic lesion. Int J Radiat Oncol Biol Phys 53(5):1216-24, 2002. PMID: 12128123.
Stewart AL, Mhashilkar AM, Yang XH, Ekmekcioglu S, Saito Y, Sieger K, Schrock R, Onishi E, Swanson X, Mumm JB, Zumstein L, Watson GJ, Snary D, Roth JA, Grimm EA, Ramesh R, Chada S. PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells. Mol Med 8(8):451-61, 2002. PMID: 12435856.
Gu J, Zhang L, Huang X, Lin T, Yin M, Xu K, Ji L, Roth JA, Fang B. A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo. Oncogene 21(31):4757-64, 2002. PMID: 12101414.
Saeki T, Mhashilkar A, Swanson X, Zou-Yang XH, Sieger K, Kawabe S, Branch CD, Zumstein L, Meyn RE, Roth JA, Chada S, Ramesh R. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 21(29):4558-66, 2002. PMID: 12085234.
Tango Y, Fujiwara T, Itoshima T, Takata Y, Katsuda K, Uno F, Ohtani S, Tani T, Roth JA, Tanaka N. Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells. Hum Gene Ther 13(11):1373-82, 2002. PMID: 12162819.
Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 277(23):20301-8, 2002. PMID: 11909872.
Tanyi JL, Lapushin R, Eder A, Auersperg N, Tabassam FH, Roth JA, Gu J, Fang B, Mills GB, Wolf J. Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells. Gynecol Oncol 85(3):451-8, 2002. PMID: 12051873.
Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res 62(9):2715-20, 2002. PMID: 11980673.
Nakamura S, Roth JA, Mukhopadhyay T. Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells. Oncogene 21(16):2605-10, 2002. PMID: 11971195.
Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 62(8):2239-43, 2002. PMID: 11956076.
Honda T, Kagawa S, Spurgers KB, Gjertsen BT, Roth JA, Fang B, Lowe SL, Norris JS, Meyn RE, McDonnell TJ. A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity. Cancer Biol Ther 1(2):163-7, 2002. PMID: 12170776.
Katsuda K, Kataoka M, Uno F, Murakami T, Kondo T, Roth JA, Tanaka N, Fujiwara T. Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. Oncogene 21(13):2108-13, 2002. PMID: 11960384.
Nakamura S, Gomyo Y, Roth JA, Mukhopadhyay T. C-terminus of p53 is required for G(2) arrest. Oncogene 21(13):2102-7, 2002. PMID: 11960383.
Nikitina EY, Chada S, Muro-Cacho C, Fang B, Zhang R, Roth JA, Gabrilovich DI. An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53. Gene Ther 9(5):345-52, 2002. PMID: 11938454.
Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG. Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem 277(11):9219-25, 2002. PMID: 11741880.
Swisher SG, Roth JA, Carbone DP. Genetic and immunologic therapies for lung cancer. Semin Oncol 29(1 Suppl 4):95-101, 2002. PMID: 11894019.
Vaporciyan AA, Merriman KW, Ece F, Roth JA, Smythe WR, Swisher SG, Walsh GL, Nesbitt JC, Putnam JB. Incidence of major pulmonary morbidity after pneumonectomy: association with timing of smoking cessation. Ann Thorac Surg 73(2):420-5; discussion 425-6, 2002. PMID: 11845853.
Gu J, Andreeff M, Roth JA, Fang B. hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngeneic mouse tumor model and prevents systemic toxicity. Gene Ther 9(1):30-7, 2002. PMID: 11850720.
Swisher SG, Wynn P, Putnam JB, Mosheim MB, Correa AM, Komaki RR, Ajani JA, Smythe WR, Vaporciyan AA, Roth JA, Walsh GL. Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J Thorac Cardiovasc Surg 123(1):175-83, 2002. PMID: 11782772.
Vaporciyan AA, Rice DC, Correa AM, Walsh GL, Putnam JB Jr, Swisher SG, Smythe WR, Roth JA. Resection of advanced thoracic malignancies requiring cardiopulmonary bypass. Eur J Cardiothorac Surg 22:47-52, 2002.
Merritt JA, Roth JA, Logothetis CJ. Clinical evaluation of adenoviral-mediated p53 gene transfer: review of INGN 201 studies. Semin Oncol 28(5 Suppl 16):105-14, 2001. PMID: 11706402.
Honda T, Gjertsen BT, Spurgers KB, Briones F, Lee SJ, Hobbs ML, Meyn RE, Roth JA, Logothetis C, McDonnell TJ. Restoration of bax in prostate cancer suppresses tumor growth and augments therapeutic cell death induction. Anticancer Res 21(5):3141-6, 2001. PMID: 11848465.
Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells. Oncogene 20(43):6258-62, 2001. PMID: 11593436.
Nishizaki M, Meyn RE, Levy LB, Atkinson EN, White RA, Roth JA, Ji L. Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo. Clin Cancer Res 7(9):2887-97, 2001. PMID: 11555607.
Fukazawa T, Fujiwara T, Uno F, Teraishi F, Kadowaki Y, Itoshima T, Takata Y, Kagawa S, Roth JA, Tschopp J, Tanaka N. Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene 20(37):5225-31, 2001. PMID: 11526513.
Roth JA, Grammer SF, Swisher SG, Komaki R, Nemunaitis J, Merritt J, Fujiwara T, Meyn RE, Jr. Gene therapy approaches for the management of non-small cell lung cancer. Semin Oncol 28(4 Suppl 14):50-6, 2001. PMID: 11605184.
Ajani JA, Komaki R, Putnam JB, Walsh G, Nesbitt J, Pisters PW, Lynch PM, Vaporciyan A, Smythe R, Lahoti S, Raijman I, Swisher S, Martin FD, Roth JA. A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction. Cancer 92(2):279-86, 2001. PMID: 11466680.
Mhashilkar A, Chada S, Roth JA, Ramesh R. Gene therapy. Therapeutic approaches and implications. Biotechnol Adv 19(4):279-97, 2001. PMID: 14538077.
Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA, Fang B. Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res 7(5):1474-80, 2001. PMID: 11350920.
Kagawa S, He C, Gu J, Koch P, Rha SJ, Roth JA, Curley SA, Stephens LC, Fang B. Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. Cancer Res 61(8):3330-8, 2001. PMID: 11309289.
Lakka SS, Ramesh R, Rajan MK, Mohan PM, Adachi Y, Dinh DH, Olivero WC, Gujrati M, Ali-Osman F, Roth JA, Yung WK, Kyritsis AP, Rao JS. Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines. Clin Cancer Res 7:1087-93, 2001. PMID: 11309361.
Lippman SM, Lee JJ, Karp DD, Vokes EE, Benner SE, Goodman GE, Khuri FR, Marks R, Winn RJ, Fry W, Graziano SL, Gandara DR, Okawara G, Woodhouse CL, Williams B, Perez C, Kim HW, Lotan R, Roth JA, Hong WK. Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. J Natl Cancer Inst 93(8):605-18, 2001. PMID: 11309437.
Mhashilkar AM, Schrock RD, Hindi M, Liao J, Sieger K, Kourouma F, Zou-Yang XH, Onishi E, Takh O, Vedvick TS, Fanger G, Stewart L, Watson GJ, Snary D, Fisher PB, Saeki T, Roth JA, Ramesh R, Chada S. Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol Med 7(4):271-82, 2001. PMID: 11471572.
Siegenthaler MP, Pisters KM, Merriman KW, Roth JA, Swisher SG, Walsh GL, Vaporciyan AA, Smythe WR, Putnam JB, Jr. Preoperative chemotherapy for lung cancer does not increase surgical morbidity. Ann Thorac Surg 71(4):1105-11; discussion 1111-2, 2001. PMID: 11308144.
Koch PE, Guo ZS, Kagawa S, Gu J, Roth JA, Fang B. Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system. Mol Ther 3(3):278-83, 2001. PMID: 11273768.
Ramesh R, Saeki T, Templeton NS, Ji L, Stephens LC, Ito I, Wilson DR, Wu Z, Branch CD, Minna JD, Roth JA. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 3(3):337-50, 2001. PMID: 11273776.
Smythe WR, Estrera AL, Swisher SG, Merriman KW, Walsh GL, Putnam JB, Jr, Vaporciyan AA, Roth JA. Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma. Ann Thorac Surg 71(3):962-6, 2001. PMID: 11269481.
Kawabe S, Munshi A, Zumstein LA, Wilson DR, Roth JA, Meyn RE. Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts. Int J Radiat Biol 77(2):185-94, 2001. PMID: 11236925.
Schnirer II, Komaki R, Yao JC, Swisher S, Putnam J, Pisters PW, Roth JA, Ajani JA. Pilot study of concurrent 5-fluorouracil/paclitaxel plus radiotherapy in patients with carcinoma of the esophagus and gastroesophageal junction. Am J Clin Oncol 24:91-5, 2001. PMID: 11232959.
Komaki R, Cox JD, Putnam Jr JB, Walsh G, Vaporciyan A, Liao Z, Stevens C, Fossella FV, Lee JS, Hong WK, Roth JA. The management of superior sulcus tumors. J Jpn. Soc Ther Radiol Oncol 13:131-138, 2001.
Li X, Marani M, Yu J, Nan B, Roth JA, Kagawa S, Fang B, Denner L, Marcelli M. Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res 61(1):186-91, 2001. PMID: 11196158.
Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg 121(1):61-7, 2001. PMID: 11135160.
Roth JA, Grammer SF, Swisher SG, Komaki R, Nemunaitis J, Merritt J, Meyn RE. p53 gene replacement for cancer--interactions with DNA damaging agents. Acta Oncol 40:739-44, 2001. PMID: 11765069.
Schumacher G, Bruckheimer EM, Beham AW, Honda T, Brisbay S, Roth JA, Logothetis C, McDonnell TJ. Molecular determinants of cell death induction following adenovirus-mediated gene transfer of wild-type p53 in prostate cancer cells. Int J Cancer 91(2):159-66, 2001. PMID: 11146439.
Walsh GL, Davis BM, Swisher SG, Vaporciyan AA, Smythe WR, Willis-Merriman K, Roth JA, Putnam JB, Jr. A single-institutional, multidisciplinary approach to primary sarcomas involving the chest wall requiring full-thickness resections. J Thorac Cardiovasc Surg 121(1):48-60, 2001. PMID: 11135159.
Nakamura S, Roth JA, Mukhopadhyay T. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol Cell Biol 20(24):9391-8, 2000. PMID: 11094089.
Saeki T, Mhashilkar A, Chada S, Branch C, Roth JA, Ramesh R. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 7(23):2051-7, 2000. PMID: 11175318.
Cowen D, Salem N, Ashoori F, Meyn R, Meistrich ML, Roth JA, Pollack A. Prostate cancer radiosensitization in vivo with adenovirus-mediated p53 gene therapy. Clin Cancer Res 6(11):4402-8, 2000. PMID: 11106260.
Huober JB, Nakamura S, Meyn R, Roth JA, Mukhopadhyay T. Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 48(4):1127-37, 2000. PMID: 11072172.
Kawabe S, Roth JA, Wilson DR, Meyn RE. Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner. Oncogene 19(47):5359-66, 2000. PMID: 11103937.
Waku T, Fujiwara T, Shao J, Itoshima T, Murakami T, Kataoka M, Gomi S, Roth JA, Tanaka N. Contribution of CD95 ligand-induced neutrophil infiltration to the bystander effect in p53 gene therapy for human cancer. J Immunol 165(10):5884-90, 2000. PMID: 11067949.
Gu J, Kagawa S, Takakura M, Kyo S, Inoue M, Roth JA, Fang B. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res 60(19):5359-64, 2000. PMID: 11034071.
Weill D, Mack M, Roth J, Swisher S, Proksch S, Merritt J, Nemunaitis J. Adenoviral-mediated p53 gene transfer to non-small cell lung cancer through endobronchial injection. Chest 118(4):966-70, 2000. PMID: 11035664.
Komaki R, Roth JA, Walsh GL, Putnam JB, Vaporciyan A, Lee JS, Fossella FV, Chasen M, Delclos ME, Cox JD. Outcome predictors for 143 patients with superior sulcus tumors treated by multidisciplinary approach at the University of Texas M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys 48(2):347-54, 2000. PMID: 10974447.
Sueoka N, Lee HY, Walsh GL, Fang B, Ji L, Roth JA, LaPushin R, Hong WK, Cohen P, Kurie JM. Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment. Am J Respir Cell Mol Biol 23(3):297-303, 2000. PMID: 10970819.
Sueoka N, Lee HY, Wiehle S, Cristiano RJ, Fang B, Ji L, Roth JA, Hong WK, Cohen P, Kurie JM. Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene 19(38):4432-6, 2000. PMID: 10980619.
Schneider PM, Praeuer HW, Stoeltzing O, Boehm J, Manning J, Metzger R, Fink U, Wegerer S, Hoelscher AH, Roth JA. Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer. Br J Cancer 83(4):473-9, 2000. PMID: 10945494.
Schneider PM, Stoeltzing O, Roth JA, Hoelscher AH, Wegerer S, Mizumoto S, Becker K, Dittler HJ, Fink U, Siewert JR. p53 mutational status improves estimation of prognosis in patients with curatively resected adenocarcinoma in Barrett's esophagus. Clin Cancer Res 6:3153-8, 2000. PMID: 10955797.
Itoshima T, Fujiwara T, Waku T, Shao J, Kataoka M, Yarbrough WG, Liu TJ, Roth JA, Tanaka N, Kodama M. Induction of apoptosis in human esophageal cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes: involvement of p53 accumulation via ARF-mediated MDM2 down-regulation. Clin Cancer Res 6(7):2851-9, 2000. PMID: 10914734.
Owen-Schaub L, Chan H, Cusack JC, Roth J, Hill LL. Fas and Fas ligand interactions in malignant disease. Int J Oncol 17(1):5-12, 2000. PMID: 10853011.
Swisher SG, DeFord L, Merriman KW, Walsh GL, Smythe R, Vaporciyan A, Ajani JA, Brown T, Komaki R, Roth JA, Putnam JB. Effect of operative volume on morbidity, mortality, and hospital use after esophagectomy for cancer. J Thorac Cardiovasc Surg 119(6):1126-32, 2000. PMID: 10838528.
Horio Y, Hasegawa Y, Sekido Y, Takahashi M, Roth JA, Shimokata K. Synergistic effects of adenovirus expressing wild-type p53 on chemosensitivity of non-small cell lung cancer cells. Cancer Gene Ther 7(4):537-44, 2000. PMID: 10811471.
Yen N, Ioannides CG, Xu K, Swisher SG, Lawrence DD, Kemp BL, El-Naggar AK, Cristiano RJ, Fang B, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Merritt JA, Mukhopadhyay T, Nesbitt JC, Nguyen D, Perez-Soler R, Pisters KM, Putnam JB, Jr, Schrump DS, Shin DM, Walsh GL, Roth JA. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type. P53 (Ad-p53). Cancer Gene Ther 7(4):530-6, 2000. PMID: 10811470.
Kagawa S, Gu J, Swisher SG, Ji L, Roth JA, Lai D, Stephens LC, Fang B. Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines. Cancer Res 60(5):1157-61, 2000. PMID: 10728665.
Kataoka M, Wiehle S, Spitz F, Schumacher G, Roth JA, Cristiano RJ. Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells. Oncogene 19(12):1589-95, 2000. PMID: 10734319.
Pearson AS, Spitz FR, Swisher SG, Kataoka M, Sarkiss MG, Meyn RE, McDonnell TJ, Cristiano RJ, Roth JA. Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. Clin Cancer Res 6(3):887-90, 2000. PMID: 10741712.
Nemunaitis J, Swisher SG, Timmons T, Connors D, Mack M, Doerksen L, Weill D, Wait J, Lawrence DD, Kemp BL, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Richli WR, Shin DM, Walsh GL, Merritt J, Roth J. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 18(3):609-22, 2000. PMID: 10653876.
Putnam JB, Jr, Walsh GL, Swisher SG, Roth JA, Suell DM, Vaporciyan AA, Smythe WR, Merriman KW, DeFord LL. Outpatient management of malignant pleural effusion by a chronic indwelling pleural catheter. Ann Thorac Surg 69(2):369-75, 2000. PMID: 10735665.
Shao J, Fujiwara T, Kadowaki Y, Fukazawa T, Waku T, Itoshima T, Yamatsuji T, Nishizaki M, Roth JA, Tanaka N. Overexpression of the wild-type p53 gene inhibits NF-κB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells. Oncogene 19:726-36, 2000. PMID: 10698490.
Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res 60:788-92, 2000. PMID: 10706081.
Kagawa S, Pearson SA, Ji L, Xu K, McDonnell TJ, Swisher SG, Roth JA, Fang B. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther 7(1):75-9, 2000. PMID: 10680019.
Komaki R, Roth JA, Swisher SG, Meyn RE Jr. Gene targeting treatment for non-small cell lung cancer. Proc Biol Appr Cancer Treat 13:29-34, 2000.
Swisher SG, Roth JA. Gene therapy in lung cancer. Curr Oncol Rep 2(1):64-70, 2000. PMID: 11122826.
Kadowaki Y, Fujiwara T, Fukazawa T, Shao J, Yasuda T, Itoshima T, Kagawa S, Hudson LG, Roth JA, Tanaka N. Induction of differentiation-dependent apoptosis in human esophageal squamous cell carcinoma by adenovirus-mediated p21sdi1 gene transfer. Clin Cancer Res 5(12):4233-41, 1999. PMID: 10632365.
Pearson AS, Koch PE, Atkinson N, Xiong M, Finberg RW, Roth JA, Fang B. Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines. Clin Cancer Res 5(12):4208-13, 1999. PMID: 10632362.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Habib NA, et al. Human gene marker/therapy clinical protocols. Hum Gene Ther 10(18):3067-123, 1999. PMID: 10609664.
Gandhi S, Walsh GL, Komaki R, Gokaslan ZL, Nesbitt JC, Putnam JB, Jr, Roth JA, Merriman KW, McCutcheon IE, Munden RF, Swisher SG. A multidisciplinary surgical approach to superior sulcus tumors with vertebral invasion. Ann Thorac Surg 68(5):1778-84; discussion 1784-5, 1999. PMID: 10585058.
Wolf JK, Mills GB, Bazzet L, Bast RC, Jr, Roth JA, Gershenson DM. Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status. Gynecol Oncol 75(2):261-6, 1999. PMID: 10525383.
Kagawa S, Fujiwara T, Kadowaki Y, Fukazawa T, Sok-Joo R, Roth JA, Tanaka N. Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer. Cell Death Differ 6(8):765-72, 1999. PMID: 10467350.
Ji L, Fang B, Yen N, Fong K, Minna JD, Roth JA. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res 59(14):3333-9, 1999. PMID: 10416589.
Mohan PM, Chintala SK, Mohanam S, Gladson CL, Kim ES, Gokaslan ZL, Lakka SS, Roth JA, Fang B, Sawaya R, Kyritsis AP, Rao JS. Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res 59(14):3369-73, 1999. PMID: 10416596.
Beaupre DM, Talpaz M, Marini FC, 3rd, Cristiano RJ, Roth JA, Estrov Z, Albitar M, Freedman MH, Kurzrock R. Autocrine interleukin-1β production in leukemia: evidence for the involvement of mutated RAS. Cancer Res 59:2971-80, 1999. PMID: 10383163.
Ji L, Fang B, Roth JA. A rapid, sensitive, and nonradioactive method for assay of FHIT Ap3A hydrolase activity by fluorescence thin-layer chromatographic image analysis. Anal Biochem 271(1):114-6, 1999. PMID: 10361018.
Nishizaki M, Fujiwara T, Tanida T, Hizuta A, Nishimori H, Tokino T, Nakamura Y, Bouvet M, Roth JA, Tanaka N. Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clin Cancer Res 5(5):1015-23, 1999. PMID: 10353734.
Swisher SG, Roth JA, Nemunaitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mack M, Merritt JA, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Jr, Richli WR, Savin M, Schrump DS, Shin DM, Shulkin A, Walsh GL, Wait J, Weill D, Waugh MK. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst 91(9):763-71, 1999. PMID: 10328106.
Fukazawa T, Fujiwara T, Morimoto Y, Shao J, Nishizaki M, Kadowaki Y, Hizuta A, Owen-Schaub LB, Roth JA, Tanaka N. Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells. Oncogene 18(13):2189-99, 1999. PMID: 10327065.
Ji L, Bouvet M, Price RE, Roth JA, Fang B. Reduced toxicity, attenuated immunogenicity and efficient mediation of human p53 gene expression in vivo by an adenovirus vector with deleted E1-E3 and inactivated E4 by GAL4-TATA promoter replacement. Gene Ther 6(3):393-402, 1999. PMID: 10435089.
Schumacher G, Kataoka M, Roth JA, Mukhopadhyay T. Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines. Clin Cancer Res 5(3):493-9, 1999. PMID: 10100698.
Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [see comments]. Ann Surg Oncol 5(8):681-8, 1998. PMID: 9869513.
Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, Estes N, Haller DG, Ajani J, Kocha W, Minsky BD, Roth JA. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med 339(27):1979-84, 1998. PMID: 9869669.
Mukhopadhyay T, Roth JA, Acosta SA, Maxwell SA. Two-dimensional gel analysis of apoptosis-specific p53 isoforms induced by 2-methoxyestradiol in human lung cancer cells. Apoptosis 3(6):421-30, 1998. PMID: 14646475.
Kataoka M, Schumacher G, Cristiano RJ, Atkinson EN, Roth JA, Mukhopadhyay T. An agent that increases tumor suppressor transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo. Cancer Res 58(21):4761-5, 1998. PMID: 9809972.
Fang B, Xu B, Koch P, Roth JA. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 5(10):1420-4, 1998. PMID: 9930348.
Roth JA. Restoration of tumour suppressor gene expression for cancer. Forum (Genova) 8(4):368-76, 1998. PMID: 9863031.
Xu B, Wiehle S, Roth JA, Cristiano RJ. The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther 5(9):1235-43, 1998. PMID: 9930325.
Mukhopadhyay T, Multani AS, Roth JA, Pathak S. Reduced telomeric signals and increased telomeric associations in human lung cancer cell lines undergoing p53-mediated apoptosis. Oncogene 17(7):901-6, 1998. PMID: 9780006.
Mukhopadhyay T, Roth JA. Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis. Oncogene 17(2):241-6, 1998. PMID: 9674709.
Roth JA, Atkinson EN, Fossella F, Komaki R, Ryan MB, Putnam JB, Jr, Lee JS, Dhingra H, De Caro L, Chasen M, Hong WK. Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Lung Cancer 21:1-6, 1998. PMID: 9792048.
Shin DM, Walsh GL, Komaki R, Putnam JB, Nesbitt J, Ro JY, Shin HJ, Ki KH, Wimberly A, Pisters KM, Schrump D, Gregurich MA, Cox JD, Roth JA, Hong WK. A multidisciplinary approach to therapy for unresectable malignant thymoma. Ann Intern Med 129(2):100-4, 1998. PMID: 9669967.
Bouvet M, Ellis LM, Nishizaki M, Fujiwara T, Liu W, Bucana CD, Fang B, Lee JJ, Roth JA. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res 58(11):2288-92, 1998. PMID: 9622060.
Clayman GL, El-Naggar AK, Lippman SM, Henderson YC, Frederick M, Merritt JA, Zumstein LA, Timmons TM, Liu TJ, Ginsberg L, Roth JA, Hong WK, Bruso P, Goepfert H. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 16(6):2221-32, 1998. PMID: 9626224.
Roth JA, Swisher SG, Merritt JA, Lawrence DD, Kemp BL, Carrasco CH, El-Naggar AK, Fossella FV, Glisson BS, Hong WK, Khurl FR, Kurie JM, Nesbitt JC, Pisters K, Putnam JB, Schrump DS, Shin DM, Walsh GL. Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement. Semin Oncol 25(3 Suppl 8):33-7, 1998. PMID: 9704675.
Tada M, Sakuma S, Iggo RD, Saya H, Sawamura Y, Fujiwara T, Roth JA. Monitoring adenoviral p53 transduction efficiency by yeast functional assay. Gene Ther 5(3):339-44, 1998. PMID: 9614553.
Bouvet M, Fang B, Ekmekcioglu S, Ji L, Bucana CD, Hamada K, Grimm EA, Roth JA. Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide. Gene Ther 5(2):189-95, 1998. PMID: 9578838.
Fang B, Ji L, Bouvet M, Roth JA. Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery. J Biol Chem 273(9):4972-5, 1998. PMID: 9478943.
Fang X, Jin X, Xu HJ, Liu L, Peng HQ, Hogg D, Roth JA, Yu Y, Xu F, Bast RC, Jr, Mills GB. Expression of p16 induces transcriptional downregulation of the RB gene. Oncogene 16(1):1-8, 1998. PMID: 9467937.
Mukhopadhyay T, Roth JA. Isolation of total RNA from tissues or cell lines. Visualization in gel. Methods Mol Biol 86:55-9, 1998. PMID: 9664453.
Schumacher G, Kataoka M, Roth JA, Mukhopadhyay T. [2-methoxyestradiol induces p53 independent apoptosis in pancreatic carcinoma and inhibits growth of lung metastasis]. Langenbecks Arch Chir Suppl Kongressbd 115(Suppl I):49-52, 1998. PMID: 14518211.
Cristiano RJ, Xu B, Nguyen D, Schumacher G, Kataoka M, Spitz FR, Roth JA. Viral and nonviral gene delivery vectors for cancer gene therapy. Cancer Detect Prev 22:445-54, 1998.
Fang B, Koch P, Bouvet M, Ji L, Roth JA. A packaging system for SV40 vectors without viral coding sequences. Anal Biochem 254(1):139-43, 1997. PMID: 9398356.
Walsh GL, Gokaslan ZL, McCutcheon IE, Mineo MT, Yasko AW, Swisher SG, Schrump DS, Nesbitt JC, Putnam JB, Jr, Roth JA. Anterior approaches to the thoracic spine in patients with cancer: indications and results. Ann Thorac Surg 64(6):1611-8, 1997. PMID: 9436544.
Ogawa N, Fujiwara T, Kagawa S, Nishizaki M, Morimoto Y, Tanida T, Hizuta A, Yasuda T, Roth JA, Tanaka N. Novel combination therapy for human colon cancer with adenovirus-mediated wild-type p53 gene transfer and DNA-damaging chemotherapeutic agent. Int J Cancer 73(3):367-70, 1997. PMID: 9359484.
Kagawa S, Fujiwara T, Hizuta A, Yasuda T, Zhang WW, Roth JA, Tanaka N. p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells. Oncogene 15(16):1903-9, 1997. PMID: 9365236.
Fang B, Koch P, Roth JA. Diminishing adenovirus gene expression and viral replication by promoter replacement. J Virol 71(6):4798-803, 1997. PMID: 9151874.
Nguyen DM, Wiehle SA, Koch PE, Branch C, Yen N, Roth JA, Cristiano RJ. Delivery of the p53 tumor suppressor gene into lung cancer cells by an adenovirus/DNA complex. Cancer Gene Ther 4(3):191-8, 1997. PMID: 9171938.
Nguyen DM, Wiehle SA, Roth JA, Cristiano RJ. Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNA complex. Cancer Gene Ther 4(3):183-90, 1997. PMID: 9171937.
Ferson DZ, Nesbitt JC, Nesbitt K, Walsh GL, Putnam JB, Jr, Schrump DS, Johansen MJ, Jones RL, Roth JA. The laryngeal mask airway: a new standard for airway evaluation in thoracic surgery. Ann Thorac Surg 63(3):768-72, 1997. PMID: 9066399.
Overholt SM, Liu TJ, Taylor DL, Wang M, El-Naggar AK, Shillitoe E, Adler-Storthz K, John LS, Zhang WW, Roth JA, Clayman GL. Head and neck squamous cell growth suppression using adenovirus-p53-FLAG: a potential marker for gene therapy trials. Clin Cancer Res 3(2):185-91, 1997. PMID: 9815671.
Bouvet M, Ellis LM, Liu W, Fang B, Roth JA. Adenovirally mediated wild-type p53 gene therapy downregulates vascular endothelial growth factor expression in human colon cancer. Surg Forum 48:806-809, 1997.
Kataoka M, Komaki R, Roth JA. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Exp Med 15:251-254, 1997.
Mukhopadhyay T, Roth JA. Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol. Oncogene 14(3):379-84, 1997. PMID: 9018125.
Tockman MS, Mulshine JL, Piantodosi S, Erozan YS, Gupta PK, Ruckdeschel JC, Taylor PR, Zhukov T, Zhou W-H, Qiao Y-L, Yao S-X, Roth JA. Prospective detection of preclinical lung cancer: Results from 2 studies of heterogeneous nuclear ribonucloprotein A2/B1 overexpression. Clin Cancer Res 3:2237-2246, 1997.
Roth JA, Swisher SG, Lawrence DD, Kemp BL, Carrasco CH, El-Naggar AK, Fossela FV, Glisson BS, Hong WK, Khuri FR, Kurie JM, Nesbitt JC, Pisters K, Putnam JB, Jr, Schrump DS, Shin DM, Walsh GL. Gene replacement for lung cancer. Lung Cancer 18:76, 1997.
Roth JA, Swisher SG, Lawrence DD, Kemp BL, Carrasco CH, El-Naggar AK, Fossela FV, Glisson BS, Hong WK, Khuri FR, Kurie JM, Nesbitt JC, Pisters K, Putnam Jr, JB, Schrump DS, Shin DM, Walsh GL. Gene therapy strategies for lung cancer. Lung Cancer 18:141, 1997.
Horio Y, Chen A, Rice P, Roth JA, Malkinson AM, Schrump DS. Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice. Mol Carcinog 17(4):217-23, 1996. PMID: 8989915.
Hamada K, Sakaue M, Alemany R, Zhang WW, Horio Y, Roth JA, Mitchell MF. Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol Oncol 63(2):219-27, 1996. PMID: 8910631.
Maxwell SA, Roth JA, Mukhopadhyay T. Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis. Electrophoresis 17(11):1772-5, 1996. PMID: 8982610.
Nguyen DM, Spitz FR, Yen N, Cristiano RJ, Roth JA. Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 112(5):1372-6; discussion 1376-7, 1996. PMID: 8911337.
Schrump DS, Chen GA, Consuli U, Jin X, Roth JA. Inhibition of esophageal cancer proliferation by adenovirally mediated delivery of p16INK4. Cancer Gene Ther 3(6):357-64, 1996. PMID: 8988838.
Spitz FR, Nguyen D, Skibber JM, Cusack J, Roth JA, Cristiano RJ. In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer. Anticancer Res 16(6B):3415-22, 1996. PMID: 9042200.
Eicher SA, Clayman GL, Liu TJ, Shillitoe EJ, Storthz KA, Roth JA, Lotan R. Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model. Clin Cancer Res 2(10):1659-64, 1996. PMID: 9816113.
Spitz FR, Nguyen D, Skibber JM, Meyn RE, Cristiano RJ, Roth JA. Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clin Cancer Res 2(10):1665-71, 1996. PMID: 9816114.
Alemany R, Ruan S, Kataoka M, Koch PE, Mukhopadhyay T, Cristiano RJ, Roth JA, Zhang WW. Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells. Cancer Gene Ther 3(5):296-301, 1996. PMID: 8894248.
Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrasco CH, Ferson DZ, Hong WK, Komaki R, Lee JJ, Nesbitt JC, Pisters KM, Putnam JB, Schea R, Shin DM, Walsh GL, Dolormente MM, Han CI, Martin FD, Yen N, Xu K, Stephens LC, McDonnell TJ, Mukhopadhyay T, Cai D. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 2(9):985-91, 1996. PMID: 8782455.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Aebischer P, et al. Human gene marker/therapy clinical protocols. Hum Gene Ther 7(13):1621-47, 1996. PMID: 8864763.
Cusack JC, Spitz FR, Nguyen D, Zhang WW, Cristiano RJ, Roth JA. High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus. Cancer Gene Ther 3(4):245-9, 1996. PMID: 8853549.
Hamada K, Alemany R, Zhang WW, Hittelman WN, Lotan R, Roth JA, Mitchell MF. Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer. Cancer Res 56(13):3047-54, 1996. PMID: 8674061.
Mukhopadhyay T, Roth JA. Functional inactivation of p53 by antisense RNA induces invasive ability of lung carcinoma cells and downregulates cytokeratin synthesis. Anticancer Res 16(4A):1683-9, 1996. PMID: 8712687.
Roth JA. Modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wildtype p53 and cisplatin. Hum Gene Ther 7(8):1013-30, 1996. PMID: 8727511.
Roth JA. Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC). Hum Gene Ther 7(7):875-89, 1996. PMID: 9147520.
Roth JA. Modification of tumor suppressor gene expression in non-small cell lung cancer (NSCLC) with a retroviral vector expressing wildtype (normal) p53. Hum Gene Ther 7(7):861-74, 1996. PMID: 8860838.
Mitchell MF, Hamada K, Sastry KJ, Sarkar A, Tortolero-Luna G, Wharton JT, Roth JA. Transgene expression in the rhesus cervix mediated by an adenovirus expressing beta-galactosidase. Am J Obstet Gynecol 174(4):1094-101, 1996. PMID: 8623835.
Hamada K, Zhang WW, Alemany R, Wolf J, Roth JA, Mitchell MF. Growth inhibition of human cervical cancer cells with the recombinant adenovirus p53 in vitro. Gynecol Oncol 60(3):373-9, 1996. PMID: 8774641.
Gomez-Manzano C, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnell TJ, Steck KD, Levin VA, Yung WK. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56(4):694-9, 1996. PMID: 8630997.
Schneider PM, Casson AG, Levin B, Garewal HS, Hoelscher AH, Becker K, Dittler HJ, Cleary KR, Troster M, Siewert JR, Roth JA. Mutations of p53 in Barrett's esophagus and Barrett's cancer: a prospective study of ninety-eight cases. J Thorac Cardiovasc Surg 111(2):323-31; discussion 331-3, 1996. PMID: 8583805.
Cristiano RJ, Roth JA. Epidermal growth factor mediated DNA delivery into lung cancer cells via the epidermal growth factor receptor. Cancer Gene Ther 3(1):4-10, 1996. PMID: 8785711.
Hamada M, Fujiwara T, Hizuta A, Gochi A, Naomoto Y, Takakura N, Takahashi K, Roth JA, Tanaka N, Orita K. The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers. J Cancer Res Clin Oncol 122(6):360-5, 1996. PMID: 8642047.
Mukhopadhyay T, Roth JA. p53 involvement in activation of the cytokeratin 8 gene in tumor cell lines. Anticancer Res 16(1):105-12, 1996. PMID: 8615594.
Mukhopadhyay T, Roth JA. WAF1 expression is independent of p53 gene alterations and protein expression in human lung cancer cells. Int J Oncol 9:405-410, 1996.
Mukhopadhyay T, Roth JA, Maxwell SA. Induction of p53 DNA-binding activity by tumor necrosis factor-α. Int J Oncol 9:715-720, 1996.
Spitz FR, Nguyen D, Skibber JM, Meyn RE, Cristiano RJ, Roth JA. Enhancement of radiation sensitivity of colorectal cancer cells by adenovirus-mediated p53 gene therapy. Surg Forum 47:481-484, 1996.
Walsh GL, O'Connor M, Willis KM, Milas M, Wong RS, Nesbitt JC, Putnam JB, Jr, Lee JJ, Roth JA. Is follow-up of lung cancer patients after resection medically indicated and cost-effective?. Ann Thorac Surg 60(6):1563-70; discussion 1570-2, 1995. PMID: 8787445.
Soysal O, Walsh GL, Nesbitt JC, McMurtrey MJ, Roth JA, Putnam JB, Jr. Resection of sternal tumors: extent, reconstruction, and survival. Ann Thorac Surg 60(5):1353-8; discussion 1358-9, 1995. PMID: 8526626.
Cai DW, Mukhopadhyay T, Roth JA. Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther 2(3):199-205, 1995. PMID: 8528963.
Jin X, Wu X, Roth JA, Amos CI, King TM, Branch C, Honn SE, Spitz MR. Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype. Carcinogenesis 16(9):2205-8, 1995. PMID: 7554076.
Mukhopadhyay T, Roth JA, Maxwell SA. Altered expression of the p50 subunit of the NF-κB transcription factor complex in non-small cell lung carcinoma. Oncogene 11(5):999-1003, 1995. PMID: 7675461.
Gingras MC, Roussel E, Roth JA, Moser RP. Little expression of cytokine mRNA by fresh tumour-infiltrating mononuclear leukocytes from glioma and lung adenocarcinoma. Cytokine 7(6):580-8, 1995. PMID: 8580376.
Jin X, Nguyen D, Zhang WW, Kyritsis AP, Roth JA. Cell cycle arrest and inhibition of tumor cell proliferation by the p16^INK4 gene mediated by an adenovirus vector. Cancer Res 55(15):3250-3, 1995. PMID: 7614457.
Nesbitt JC, Putnam JB, Jr, Walsh GL, Roth JA, Mountain CF. Survival in early-stage non-small cell lung cancer. Ann Thorac Surg 60(2):466-72, 1995. PMID: 7646126.
Putnam JB, Jr, Roth JA. Surgical treatment for pulmonary metastases from sarcoma. Hematol Oncol Clin North Am 9(4):869-87, 1995. PMID: 7490246.
Roussel E, Gingras MC, Grimm EA, Roth JA. High expression of adhesion molecules/activation markers with little interleukin-2, interferon γ, and tumor necrosis factor beta gene activation in fresh tumor-infiltrating lymphocytes from lung adenocarcinoma. Cancer Immunol Immunother 41(1):1-9, 1995. PMID: 7641214.
Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deisseroth AB, Zhang WW, Kruzel E, et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 15(6):3032-40, 1995. PMID: 7539102.
Spitz MR, Hsu TC, Wu X, Fueger JJ, Amos CI, Roth JA. Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. Cancer Epidemiol Biomarkers Prev 4(2):99-103, 1995. PMID: 7537995.
Wang J, Bucana CD, Roth JA, Zhang WW. Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. Cancer Gene Ther 2(1):9-17, 1995. PMID: 7621257.
Zhang WW, Koch PE, Roth JA. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. Biotechniques 18(3):444-7, 1995. PMID: 7779393.
Ding ZM, Cristiano RJ, Roth JA, Takacs B, Kuo MT. Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured cells. J Biol Chem 270(8):3667-76, 1995. PMID: 7533154.
Komaki R, Shin DM, Glisson BS, Fossella FV, Murphy WK, Garden AS, Oswald MJ, Hong WK, Roth JA, Peters LJ, et al. Interdigitating versus concurrent chemotherapy and radiotherapy for limited small cell lung cancer. Int J Radiat Oncol Biol Phys 31(4):807-11, 1995. PMID: 7860392.
Zhang WW, Alemany R, Wang J, Koch PE, Ordonez NG, Roth JA. Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Hum Gene Ther 6(2):155-64, 1995. PMID: 7734516.
Ajani JA, Roth JA, Putnam JB, Walsh G, Lynch PM, Roubein LD, Ryan MB, Natrajan G, Gould P. Feasibility of five courses of pre-operative chemotherapy in patients with resectable adenocarcinoma of the oesophagus or gastrooesophageal junction. Eur J Cancer 31A(5):665-70, 1995. PMID: 7640036.
Clayman GL, el-Naggar AK, Roth JA, Zhang WW, Goepfert H, Taylor DL, Liu TJ. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 55(1):1-6, 1995. PMID: 7805018.
Kim YH, Ajani JA, Ota DM, Lynch P, Roth JA. Value of serial carcinoembryonic antigen levels in patients with resectable adenocarcinomas of the esophagus and stomach. Cancer 75:451-6, 1995. PMID: 7812915.
Nguyen D, Wiehle S, Cristiano R, Roth JA. Efficient gene delivery to malignant cells by a conjugated adenovirus/DNA complex. Surg Forum 46:475-477, 1995.
Mukhopadhyay T, Roth JA. Visualization of RNA in gel by shortwave UV epi-illumination without staining. Biotechniques 17(4):619-20, 1994. PMID: 7530454.
Walsh GL, Morice RC, Putnam JB, Jr, Nesbitt JC, McMurtrey MJ, Ryan MB, Reising JM, Willis KM, Morton JD, Roth JA. Resection of lung cancer is justified in high-risk patients selected by exercise oxygen consumption. Ann Thorac Surg 58(3):704-10; discussion 711, 1994. PMID: 7944692.
Drazan KE, Shen XD, Csete ME, Zhang WW, Roth JA, Busuttil RW, Shaked A. In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection. Surgery 116(2):197-203; discussion 203-4, 1994. PMID: 8047986.
Liu TJ, Zhang WW, Taylor DL, Roth JA, Goepfert H, Clayman GL. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res 54(14):3662-7, 1994. PMID: 8033080.
Roussel E, Gingras MC, Ro JY, Branch C, Roth JA. Loss of alpha 1 beta 1 and reduced expression of other beta 1 integrins and CAM in lung adenocarcinoma compared with pneumocytes. J Surg Oncol 56(3):198-208, 1994. PMID: 7518021.
Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB, Roth JA. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54(9):2287-91, 1994. PMID: 8162565.
Roth JA, Fossella F, Komaki R, Ryan MB, Putnam JB, Jr, Lee JS, Dhingra H, De Caro L, Chasen M, McGavran M, Atkinson EN, Hong WK.. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. J Natl Cancer Inst 86:673-80, 1994. PMID: 8158698.
Fujiwara T, Mukhopadhyay T, Cai DW, Morris DK, Roth JA, Grimm EA. Retroviral-mediated transduction of p53 gene increases TGF-β expression in a human glioblastoma cell line. Int J Cancer 56:834-9, 1994. PMID: 8119773.
Zhang WW, Fang X, Mazur W, French BA, Georges RN, Roth JA. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1(1):5-13, 1994. PMID: 7621238.
Putnam JB, Jr, Suell DM, McMurtrey MJ, Ryan MB, Walsh GL, Natarajan G, Roth JA. Comparison of three techniques of esophagectomy within a residency training program. Ann Thorac Surg 57(2):319-25, 1994. PMID: 8311591.
Casson AG, Manolopoulos B, Troster M, Kerkvliet N, O'Malley F, Inculet R, Finley R, Roth JA. Clinical implications of p53 gene mutation in the progression of Barrett's epithelium to invasive esophageal cancer. Am J Surg 167(1):52-7, 1994. PMID: 8311140.
Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB, Roth JA. Induction of chemosensitivity in human cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Surg Forum 45:524-526, 1994.
Green MR, Cox JD, Ardizzoni A, Arriagada R, Bureau G, Darwish S, Deneffe G, Fukuoka M, Joseph D, Komaki R, Roth JA. Endpoints for multimodal clinical trials in stage III non-small cell lung cancer (NSCLC): A consensus report. Lung Cancer 11:S11-S13, 1994.
Green MR, Ginsberg R, Ardizzoni A, Choi N, Darwish S, Fukuoka M, Giner V, Grunenwald D, Harper P, Kho S, Le Chavalier T, Lewinski T, Payne D, Postmus P, Rochmans P, Rosell R, Roth JA, Sculier J-P, Sorensen JB. Induction therapy for stage III NSCLC: A consensus report. Lung Cancer 11:S9-S10, 1994.
Pass HI, Sindelar WF, Kinsella TJ, Deluca AM, Barnes M, Kurtzman S, Hoekstra H, Tochner Z, Roth JA, Glatstein, E. Delivery of intraoperative radiation therapy (IORT) after pneumonectomy: experimental observations and early clinical results. Ann Thorac Surg 58:269-270, 1994.
Shin DM, Kim J, Ro JY, Hittelman J, Roth JA, Hong WK, Hittelman WN. Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54(2):321-6, 1994. PMID: 8275461.
Tockman MS, Erozan YS, Gupta PK, Piantadosi S, Mulshine JL, Ruckdeschel J, Roth JA. The early detection of second primary lung cancers by sputum immunostaining. Chest 106:385s-390s, 1994.
Fujiwara T, Cai DW, Georges RN, Mukhopadhyay T, Grimm EA, Roth JA. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. Commentary. J Natl Cancer Inst 86:1458-1462, 1994. PMID: 8089864.
Zhang WW, Roth JA. Anti-oncogene and tumor suppressor gene therapy - examples of lung cancer animal model. In vivo 8:755-770, 1994.
Maxwell SA Roth JA. Binding of cellular proteins to a conformational domain of tumor suppressor protein p53. Oncogene 8(12):3421-6, 1993. PMID: 8247546.
Srinivasan R, Roth JA, Maxwell SA. Sequence-specific interaction of a conformational domain of p53 with DNA. Cancer Res 53(22):5361-4, 1993. PMID: 8221671.
Zhang WW, Fang X, Branch CD, Mazur W, French BA, Roth JA. Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis. Biotechniques 15(5):868-72, 1993. PMID: 8267983.
Cai DW, Mukhopadhyay T, Liu Y, Fujiwara T, Roth JA. Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum Gene Ther 4(5):617-24, 1993. PMID: 8280799.
Fujiwara T, Grimm EA, Mukhopadhyay T, Cai DW, Owen-Schaub LB, Roth JA. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res 53(18):4129-33, 1993. PMID: 8395976.
Mukhopadhyay T Roth JA. A codon 248 p53 mutation retains tumor suppressor function as shown by enhancement of tumor growth by antisense p53. Cancer Res 53(18):4362-6, 1993. PMID: 8364931.
Zhang Y, Mukhopadhyay T, Donehower LA, Georges RN, Roth JA. Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype. Hum Gene Ther 4(4):451-60, 1993. PMID: 8399492.
Putnam JB, Jr, Suell DM, Natarajan G, Roth JA. Extended resection of pulmonary metastases: is the risk justified?. Ann Thorac Surg 55(6):1440-6, 1993. PMID: 8512393.
Chung KY, Mukhopadhyay T, Kim J, Casson A, Ro JY, Goepfert H, Hong WK, Roth JA. Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res 53(7):1676-83, 1993. PMID: 8453641.
Georges RN, Mukhopadhyay T, Zhang Y, Yen N, Roth JA. Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res 53(8):1743-6, 1993. PMID: 8467490.
Mukhopadhyay T, Roth JA. Silicone lubricant enhances recovery of nucleic acids after phenol-chloroform extraction. Nucleic Acids Res 21(3):781-2, 1993. PMID: 8441704.
Ajani JA, Roth JA, Ryan MB, Putnam JB, Pazdur R, Levin B, Gutterman JU, McMurtrey M. Intensive preoperative chemotherapy with colony-stimulating factor for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol 11(1):22-8, 1993. PMID: 8418237.
Pogrebniak HW, Matthews W, Black C, Russo A, Mitchell JB, Smith P, Roth JA, Pass HI. Targetted phototherapy with sensitizer-monoclonal antibody conjugate and light. Surg Oncol 2(1):31-42, 1993. PMID: 8252191.
Lazenby AW, Roth JA, Owen-Schaub LB, Grimm EA. IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-α and β (lymphotoxin). Cytokine 4:479-87, 1992. PMID: 1337985.
Cybulsky IJ, Lanza LA, Ryan MB, Putnam JB, Jr, McMurtrey MM, Roth JA. Prognostic significance of computed tomography in resected N2 lung cancer. Ann Thorac Surg 54(3):533-7, 1992. PMID: 1324657.
Lanza LA, Natarajan G, Roth JA, Putnam JB, Jr. Long-term survival after resection of pulmonary metastases from carcinoma of the breast. Ann Thorac Surg 54(2):244-7; discussion 248, 1992. PMID: 1637212.
Roth JA. New approaches to treating early lung cancer. Cancer Res 52(9 Suppl):2652s-2657s, 1992. PMID: 1562995.
Casson AG, Putnam JB, Natarajan G, Johnston DA, Mountain C, McMurtrey M, Roth JA. Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma. Cancer 69(3):662-8, 1992. PMID: 1730117.
Morice RC, Peters EJ, Ryan MB, Putnam JB, Ali MK, Roth JA. Exercise testing in the evaluation of patients at high risk for complications from lung resection. Chest 101(2):356-61, 1992. PMID: 1735254.
Putnam EA, Yen N, Gallick GE, Steck PA, Fang K, Akpakip B, Gazdar AF, Roth JA. Autocrine growth stimulation by transforming growth factor-α in human non-small cell lung cancer. Surg Oncol 1:49-60, 1992. PMID: 1341235.
Ajani JA, Ryan B, Rich TA, McMurtrey M, Roth JA, DeCaro L, Levin B, Mountain C. Prolonged chemotherapy for localised squamous carcinoma of the oesophagus. Eur J Cancer 28A(4-5):880-4, 1992. PMID: 1524915.
Georges RN, Zhang Y, Mukhopadhyay T, Roth JA. Retroviral mediated gene transfer of antisense K-ras suppresses tumor growth in an orthotopic lung cancer model. Surg Forum 43:490-491, 1992.
Yang SC, Grimm EA, Roth JA. Combination immunotherapy for advanced lung cancer. J Natl Cancer Inst Monogr 13:197-201, 1992. PMID: 1327033.
Mukhopadhyay T, Roth JA. A simple and efficient method for isolation of DNA fragments from agarose gel. Nucleic Acids Res 19(23):6656, 1991. PMID: 1754414.
Yang SC, Fry KD, Grimm EA, Roth JA. Phenotype and cytolytic activity of mouse tumor-bearer splenocytes and tumor-infiltrating lymphocytes from K-1735 melanoma metastases following anti-CD3, interleukin-2, and tumor necrosis factor-α combination immunotherapy. J Immunother 10:326-35, 1991. PMID: 1790140.
Zatopek NK, Holoye PY, Ellerbroek NA, Hong WK, Roth JA, Ryan MB, Komaki R, Pang AC, Glisson BS. Resectability of small-cell lung cancer following induction chemotherapy in patients with limited disease (stage II-IIIb). Am J Clin Oncol 14(5):427-32, 1991. PMID: 1659177.
Casson AG, Mukhopadhyay T, Cleary KR, Ro JY, Levin B, Roth JA. p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res 51(16):4495-9, 1991. PMID: 1868473.
Gorenstein LA, Putnam JB, Natarajan G, Balch CA, Roth JA. Improved survival after resection of pulmonary metastases from malignant melanoma. Ann Thorac Surg 52(2):204-10, 1991. PMID: 1863140.
Pogrebniak HW, Roth JA, Steinberg SM, Rosenberg SA, Pass HI. Re-operative pulmonary resection in patients with metastatic soft tissue sarcoma. Ann Thorac Surg 52(2):197-203, 1991. PMID: 1863139.
Robey-Cafferty SS, Ajani JA, Ota DM, Roth JA, Bruner JM. Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy. Arch Pathol Lab Med 115(8):807-12, 1991. PMID: 1713759.
Yang SC, Grimm EA, Parkinson DR, Carinhas J, Fry KD, Mendiguren-Rodriguez A, Licciardello J, Owen-Schaub LB, Hong WK, Roth JA. Clinical and immunomodulatory effects of combination immunotherapy with low-dose interleukin 2 and tumor necrosis factor-α in patients with advanced non-small cell lung cancer: a phase I trial. Cancer Res 51:3669-76, 1991. PMID: 1648441.
Casson AG, Putnam JB, Natarajan G, Johnston DA, Mountain C, McMurtrey M, Roth JA. Efficacy of pulmonary metastasectomy for recurrent soft tissue sarcoma. J Surg Oncol 47(1):1-4, 1991. PMID: 2023414.
Pass HI, Evans S, Matthews WA, Perry R, Venzon D, Roth JA, Smith P. Photodynamic therapy of oncogene-transformed cells. J Thorac Cardiovasc Surg 101(5):795-9, 1991. PMID: 1827169.
Mukhopadhyay T, Tainsky M, Cavender AC, Roth JA. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res 51(6):1744-8, 1991. PMID: 1998965.
Lanza LA, Putnam JB, Jr, Benjamin RS, Roth JA. Response to chemotherapy does not predict survival after resection of sarcomatous pulmonary metastases. Ann Thorac Surg 51(2):219-24, 1991. PMID: 1989534.
Ellerbroek NA, Fossella FV, Rich TA, Ajani JA, Komaki R, Roth JA, Holoye PY.. Low-dose continuous infusion cisplatin combined with external beam irradiation for advanced colorectal adenocarcinoma and unresectable non-small cell lung carcinoma. Int J Radiat Oncol Biol Phys 20:351-5, 1991.
Lazenby AW, Owen-Schaub LB, Crump WL, Grimm EA, Roth JA. IL-1 synergizes with interleukin-2 in the generation of cytotoxic lymphocytes via a tumor necrosis factor mediated pathway. . Surg Forum 42:472-475, 1991.
Lazenby AW, Yang SC, Sniege N, Grimm EA, Roth JA. Regression of radiation and chemotherapy resistant non-small cell lung cancer treated with combination immunotherapy. Cancer Bull 43:181-184, 1991.
Pogrebniak HW, Matthews W, Black C, Russo A, Smith P, Roth JA, Pass HI. Targeted phototherapy with sensitizer-monoclonal antibody and light. Surg Forum 42:447-449, 1991.
Yang SC, Grimm EA, Roth JA. Biologic therapy for lung cancer. Cancer Bull 43:100-108, 1991.
Yang SC, Grimm EA, Roth JA. Immunotherapy of lung cancer. Chest Surg Clin N Am 1:191-204, 1991.
Ajani JA, Roth JA, Ryan B, McMurtrey M, Rich TA, Jackson DE, Abbruzzese JL, Levin B, DeCaro L, Mountain C. Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol 8(7):1231-8, 1990. PMID: 2358838.
Putnam JB, Jr, Lammermeier DE, Colon R, McMurtrey MJ, Ali MK, Roth JA. Predicted pulmonary function and survival after pneumonectomy for primary lung carcinoma. Ann Thorac Surg 49(6):909-14; discussion 915, 1990. PMID: 2369189.
Yang SC, Owen-Schaub LB, Roth JA, Grimm EA. Characterization of OKT3-initiated lymphokine-activated effectors expanded with interleukin 2 and tumor necrosis factor-α. Cancer Res 50:3526-32, 1990. PMID: 2160321.
Perry RR, Venzon D, Roth JA, Pass HI. Survival after surgical resection for high-grade chest wall sarcomas. Ann Thorac Surg 49(3):363-8; discussion 368-9, 1990. PMID: 2310244.
Yang SC, Fry KD, Grimm EA, Roth JA. Successful combination immunotherapy for the generation in vivo of antitumor activity with anti-CD3, interleukin 2, and tumor necrosis factor-α. Arch Surg 125:220-5, 1990. PMID: 2137327.
Browne MJ, Potter D, Gress J, Cotton D, Hiemenz J, Thaler M, Hathorn J, Brower S, Gill V, Glatstein E, Pass H, Roth JA, Wesley R, Shelhamer J, Pizzo P. A randomized trial of open lung biopsy versus empiric antimicrobial therapy in cancer patients with diffuse pulmonary infiltrates. J Clin Oncol 8:222-229, 1990.
Schneider PM, Hung M-C, Ames RS, Putnam EA, Akpakip B, Roth JA. A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer. Lung Cancer 6:65-72, 1990.
Yang SC, Owen-Schaub L, Mendiguren-Rodriguez A, Grimm EA, Hong WK, Roth JA. Combination immunotherapy for non-small cell lung cancer. Results with interleukin-2 and tumor necrosis factor-α. J Thorac Cardiovasc Surg 99:8-12; discussion 12-3, 1990. PMID: 2152954.
Yang SC, Grimm EA, Roth JA. Effects of low dose OKT3 induction on the anti-tumor immune response in cancer patients receiving interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF). Surg Forum 41:434-436, 1990.
Roth JA, Thomsen S, Fry KD, Scannon P, Chang C. Analysis of gp74 expression by transformed rat fibroblasts from experimental pulmonary metastases following specific ricin A-chain immunotoxin therapy. Cancer Res 49(20):5708-12, 1989. PMID: 2676148.
Schneider PM, Hung MC, Chiocca SM, Manning J, Zhao XY, Fang K, Roth JA. Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. Cancer Res 49(18):4968-71, 1989. PMID: 2569928.
Wahi R, McMurtrey MJ, DeCaro LF, Mountain CF, Ali MK, Smith TL, Roth JA. Determinants of perioperative morbidity and mortality after pneumonectomy. Ann Thorac Surg 48(1):33-7, 1989. PMID: 2764597.
Ames RS, North SM, Fry KD, Tainsky MA, Nicolson GL, Roth JA. Analysis of expression of cell surface antigen Mr 74,000 phosphoglycoprotein in normal, oncogene-transformed, and neoplastic rat cell lines. Cancer Res 49:2312-9, 1989. PMID: 2650864.
Jablons D, Steinberg SM, Roth J, Pittaluga S, Rosenberg SA, Pass HI. Metastasectomy for soft tissue sarcoma. Further evidence for efficacy and prognostic indicators. J Thorac Cardiovasc Surg 97(5):695-705, 1989. PMID: 2709861.
Yang SC, Owen-Schaub L, Grimm EA, Roth JA. Induction of lymphokine-activated killer cytotoxicity with interleukin-2 and tumor necrosis factor-alpha against primary lung cancer targets. Cancer Immunol Immunother 29(3):193-8, 1989. PMID: 2543502.
Yang SC, Fry KD, Grimm EA, Roth JA. Reduction of pulmonary metastases following in vivo administration of anti-CD3, interleukin-2, and tumor necrosis factor-α in mice. Surg Forum 40:423-425, 1989.
Lefor AT, Merino MM, Steinberg SM, Dwyer A, Roth JA, Flanagan M, Pass HI. Computerized tomographic prediction of extraluminal spread and prognostic implications of lesion width in esophageal carcinoma. Cancer 62(7):1287-92, 1988. PMID: 3416270.
Roth JA, Pass HI, Flanagan MM, Graeber GM, Rosenberg JC, Steinberg S. Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg 96(2):242-8, 1988. PMID: 2456424.
Pogrebniak HW, Stovroff M, Roth JA, Pass HI. Resection of pulmonary metastases from malignant melanoma: results of a 16-year experience. Ann Thorac Surg 46(1):20-3, 1988. PMID: 3382281.
Roth JA, Ames RS, Fry K, Lee HM, Scannon PJ. Mediation of reduction of spontaneous and experimental pulmonary metastases by ricin A-chain immunotoxin 45-2D9-RTA with potentiation by systemic monensin in mice. Cancer Res 48:3496-501, 1988. PMID: 3259469.
Ognibene FP, Pass HI, Roth JA, Shelhamer JH, Milne EN. Role of imaging and interventional techniques in the diagnosis of respiratory disease in the immunocompromised host. J Thorac Imaging 3(2):1-20, 1988. PMID: 3283372.
Roth JA. Prognostic indicators for soft tissue sarcoma patients with pulmonary metastases. Dev Oncol 55:191-196, 1988.
Yang SC, Owen-Schaub L, Grimm EA, Roth JA. Enhancement of lymphokine-activated killer activity with interleukin-2, tumor necrosis factor-alpha, and OKT3 against primary lung cancer targets. Surg Forum 39:454-456, 1988.
Lanza LA, Miser JS, Pass HI, Roth JA. The role of resection in the treatment of pulmonary metastases from Ewing's sarcoma. J Thorac Cardiovasc Surg 94(2):181-7, 1987. PMID: 3613615.
Pass HI, Sindelar WF, Kinsella TJ, DeLuca AM, Barnes M, Kurtzman S, Hoekstra H, Tochner Z, Roth J, Glatstein E. Delivery of intraoperative radiation therapy after pneumonectomy: experimental observations and early clinical results. Ann Thorac Surg 44(1):14-20, 1987. PMID: 3038041.
Leong SP, Noguchi PD, Cunningham RE, Takami T, Roth JA. Heterogeneous expression of a murine B16 melanoma-associated antigen correlates with cell cycle. Cancer Immunol Immunother 24(2):106-12, 1987. PMID: 3829045.
Rizzoni WE, Pass HI, Wesley MN, Rosenberg SA, Roth JA. Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas. Arch Surg 121(11):1248-52, 1986. PMID: 3778195.
Edington H, Salwitz J, Longo DL, Roth JA, Pass H. Thymic hyperplasia masquerading as recurrent Hodgkin's disease: case report and review of the literature. J Surg Oncol 33(2):120-3, 1986. PMID: 3762184.
Funkhouser WK, Neckers LM, Ames RS, Carney DN, Roth JA. Inhibition of DNA synthesis by a small-cell lung carcinoma-derived protein. J Natl Cancer Inst 77(4):925-32, 1986. PMID: 3020301.
Lanza LA, Wilson DJ, Ikejiri B, Roth JA, Grimm EA. Human oncogene-transfected tumor cells display differential susceptibility to lysis by lymphokine-activated killer cells (LAK) and natural killer cells. J Immunol 137(8):2716-20, 1986. PMID: 3489774.
Roth JA, Ames RS, Restrepo C, Scuderi P. Monoclonal antibody 45-2D9 recognizes a cell surface glycoprotein on a human c-Ha-ras transformed cell line (45-342) and a shared epitope on human tumors. J Immunol 137(7):2385-9, 1986. PMID: 3531330.
Roth JA, Pass HI, Wesley MN, White D, Putnam JB, Seipp C. Comparison of median sternotomy and thoracotomy for resection of pulmonary metastases in patients with adult soft-tissue sarcomas. Ann Thorac Surg 42(2):134-8, 1986. PMID: 3741009.
Udelsman R, Roth JA, Lees D, Jelenich SE, Pass HI. Endobronchial metastases from soft tissue sarcoma. J Surg Oncol 32(3):145-9, 1986. PMID: 3736050.
McCormick KA, Carelli RM, Wesley M, Roth J, Altizer G. The effects of withdrawal methods on arterial cannula dysfunction. Mil Med 151(4):205-10, 1986. PMID: 3085010.
Pass HI, Potter D, Shelhammer J, Macher A, Ognibene FP, Longo DL, Gelmann E, Masur H, Roth JA. Indications for and diagnostic efficacy of open-lung biopsy in the patient with acquired immunodeficiency syndrome (AIDS). Ann Thorac Surg 41(3):307-12, 1986. PMID: 3954503.
Roth JA, Ames RS, Byers V, Lee HM, Scannon PJ. Monoclonal antibody 45-2D9 conjugated to the A chain of ricin is specifically toxic to c-Ha-ras-transfected NIH 3T3 cells expressing gp74. J Immunol 136(6):2305-10, 1986. PMID: 3950414.
Grimm EA, Jacobs SK, Lanza LA, Melin G, Roth JA, Wilson DJ. Interleukin 2-activated cytotoxic lymphocytes in cancer therapy. Symp Fundam Cancer Res 38:209-19, 1986. PMID: 3489259.
Lanza LA, Ames RS, Lee H, Byers V, Scannon P, Trahan EE, Roth JA. Immunotoxin to the gp74 c-Ha-ras-linked tumor antigen: serum clearance and efficacy against established metastases in a murine model. Surg Forum 37:413-415, 1986.
Inculet RI, Keller SM, Dwyer A, Roth JA. Evaluation of noninvasive tests for the preoperative staging of carcinoma of the esophagus: a prospective study. Ann Thorac Surg 40(6):561-5, 1985. PMID: 4074004.
Pass HI, Dwyer A, Makuch R, Roth JA. Detection of pulmonary metastases in patients with osteogenic and soft-tissue sarcomas: the superiority of CT scans compared with conventional linear tomograms using dynamic analysis. J Clin Oncol 3(9):1261-5, 1985. PMID: 3861775.
Brown BG, Cukingnan RA, DeRouen T, Goede LV, Wong M, Fee HJ, Roth JA, Carey JS. Improved graft patency in patients treated with platelet-inhibiting therapy after coronary bypass surgery. Circulation 72(1):138-46, 1985. PMID: 3874009.
Leong SP, Noguchi PD, Cunningham RE, Ames RS, Speiss PJ, Takami T, Roth JA. Expression of a murine B16 melanoma-associated antigen analyzed by flow cytometry. J Surg Res 38(4):383-90, 1985. PMID: 3889501.
Davidson DD, Carney DN, Putnam JB, Jr, Sugarbaker PH, Roth JA. Suppression of murine immunologic functions by fresh and cultured human tumor extracts. J Surg Res 38(3):289-97, 1985. PMID: 2984465.
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth JA, Brennan M, Costa J, et al. A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk. Cancer 55(6):1206-14, 1985. PMID: 3882217.
Roth JA, Putnam JB, Jr, Wesley MN, Rosenberg SA. Differing determinants of prognosis following resection of pulmonary metastases from osteogenic and soft tissue sarcoma patients. Cancer 55(6):1361-6, 1985. PMID: 3855684.
Chang AE, Lotze MT, Ames RS, Roth JA, Rosenberg SA. A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma. J Immunopharmacol 7(1):17-31, 1985. PMID: 3891867.
Lanza LA, Ames RS, Byers V, Lee H, Scannon P, Roth JA. Immunotoxin-mediated cytotoxity of human oncogene-transformed tumor cells. Surg Forum 35:381-383, 1985.
Potter D, Pass HI, Brower S, Macher A, Browne M, Thaler M, Cotton D, Hathorn J, Wesley R, Longo D, Pizzo P, Roth JA. Prospective randomized study of open lung biopsy versus empirical antibiotic therapy for acute pneumonitis in nonneutropenic cancer patients. Ann Thorac Surg 40:422-428, 1985.
Putnam JB, Jr, Roth JA. Identification and characterization of a tumor-derived immunosuppressive glycoprotein from murine melanoma K-1735. Cancer Immunol Immunother 19(2):90-100, 1985. PMID: 3157440.
Scuderi P, Westin E, Clagett J, Ames R, Gallo R, Blick M, Roth JA. Detection of a surface antigen on NIH3T3 cells transfected with a human leukemia oncogene. Med Oncol Tumor Pharmacother 2(4):233-42, 1985. PMID: 3910974.
Roth JA, Restrepo C, Scuderi P, Baldwin RW, Reichert CM, Hosoi S. Analysis of antigenic expression by primary and autologous metastatic human sarcomas using murine monoclonal antibodies. Cancer Res 44(11):5320-5, 1984. PMID: 6386149.
Roth JA, Scuderi P, Westin E, Gallo RC. A novel approach to production of antitumor monoclonal antibodies: antibody to a cell surface glycoprotein associated with transformation by a human oncogene. Surgery 96(2):264-72, 1984. PMID: 6379959.
Roth JA, Sugarbaker PH, Baker AR. Radical forequarter amputation with chest wall resection. Ann Thorac Surg 37(5):423-7, 1984. PMID: 6324705.
Keller SM, Papazoglou S, McKeever P, Baker A, Roth JA. Late occurrence of malignancy in a ganglioneuroma 19 years following radiation therapy to a neuroblastoma. J Surg Oncol 25(4):227-31, 1984. PMID: 6717019.
Potter DA, Strott CA, Javadpour N, Roth JA. Prolonged survival following six pulmonary resections for metastatic adrenal cortical carcinoma: a case report. J Surg Oncol 25(4):273-7, 1984. PMID: 6201679.
Putnam JB, Jr, Roth JA, Wesley MN, Johnston MR, Rosenberg SA. Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcomas. J Thorac Cardiovasc Surg 87(2):260-8, 1984. PMID: 6694417.
Funkhouser WK, Neckers LM, Ames RS, Roth JA. Human tumor cell growth inhibition by a tumor-derived glycoprotein. Surg Forum 35:394-396, 1984.
Pass HI, Potter DA, Macher AM, Reichert C, Shelhammer JH, Masur H, Ognibene F, Gelmann E, Lane HC, Fauci A, Roth JA. Thoracic manifestations of the acquired immune deficiency syndrome. J Thorac Cardiovasc Surg 88:654-658, 1984.
Putnam JB, Jr, Roth JA, Wesley MN, Johnston MR, Rosenberg SA. Survival following aggressive resection of pulmonary metastases from osteogenic sarcoma: analysis of prognostic factors. Ann Thorac Surg 36(5):516-23, 1983. PMID: 6579887.
Grimm EA, Robb RJ, Roth JA, Neckers LM, Lachman LB, Wilson DJ, Rosenberg SA. Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells. J Exp Med 158(4):1356-61, 1983. PMID: 6413638.
Roth JA, Davidson DD, Ames RS, Schneider PD. Tumor stasis factor (TSF): a possible mechanism for the regulation of tumor cell proliferation. J Surg Res 35(4):298-309, 1983. PMID: 6621026.
Roth JA. Detection of a suppressive immunoregulatory factor (IRF) in the sera of sarcoma patients by enzyme-linked immunoassay (ELISA) and correlation with clinical course. J Surg Oncol 23(4):273-81, 1983. PMID: 6876804.
Roth JA, Grimm EA, Osborne BA, Putnam JB, Jr, Davidson DD, Ames RS. Suppressive immunoregulatory factors produced by tumors. Lymphokine Res 2(2):67-73, 1983. PMID: 6332246.
Roth JA, Osborne BA, Ames RS. Immunoregulatory factors derived from human tumors. II. Partial purification and further immunobiochemical characterization of a human sarcoma-derived immunosuppressive factor expressing HLA-DR and immunoglobulin-related determinants. J Immunol 130(1):303-8, 1983. PMID: 6183354.
Thistlethwaithe P, Davidson DD, Fidler IJ, Roth JA. Syngeneic humoral immune responses to tumor-associated antigens expressed by K-1735 UV-induced melanoma and its metastases. Cancer Immunol Immunother 15(1):11-6, 1983. PMID: 6553502.
Roth JA, Wesley RA. Human tumor-associated antigens detected by serological techniques: analysis of autologous humoral immune responses to primary and metastatic human sarcomas by an enzyme-linked immunoabsorbent solid-phase assay (ELISA). Cancer Res 42(10):3978-86, 1982. PMID: 6955005.
Roth JA, Grimm EA, Gupta RK, Ames RS. Immunoregulatory factors derived from human tumors. I. Immunologic and biochemical characterization of factors that suppress lymphocyte proliferative and cytotoxic responses in vitro. J Immunol 128(5):1955-62, 1982. PMID: 6460814.
Roth JA, Osborne BA. Detection of an immunosuppressive immunoregulatory factor (IRF) in the sera of sarcoma patients by enzyme-linked immunoassay (ELISA) and correlation with clinical course. Surg Forum 33:429-431, 1982.
Schwartz J, Roth JA, Charpentier B. Effect of human lung carcinoma extract as an immunosuppressant of allografts in rats. Afr J Clin Exp Immunol 3:191-197, 1982.
Roth JA, Golub SH, Cukingnan RA, Brazier J, Morton DL. Cell-mediated immunity is depressed following cardiopulmonary bypass. Ann Thorac Surg 31(4):350-6, 1981. PMID: 7011230.
Roth JA. Humoral immune responses to human primary and metastatic sarcomas detected by an enzyme-linked immunoabsorbent solid-phase assay. Surg Forum 32:454-6, 1981.
Roth JA, Cukingnan RA, Brown BG, Gocka E, Carey JS. Factors influencing patency of saphenous vein grafts. Ann Thorac Surg 28(2):176-83, 1979. PMID: 314277.
Ramming KP, Roth JA, Mulder DG. Surgical management of extensive tracheal lesions. Am J Surg 138(1):80-8, 1979. PMID: 464213.
Roth JA, Cukingnan RA, Scott CR. Use of activated coagulation time to monitor heparin during cardiac surgery. Ann Thorac Surg 28(1):69-72, 1979. PMID: 454047.
Roth JA, Chee DO, Gupta RK, Morton DL. Studies of lymphocyte stimulation to tumor-associated antigen: II comparison of extracts from fresh human tumors with tissue culture cell lines. Cancer Immunol Immunother 7:25-29, 1979.
Roth JA Morton DL. Studies of lymphocyte stimulation to tumor-associated antigen: I. uptake of lymphocyte protein and nucleic acid precursors in response to autologous and allogeneic tumor-associated antigen solubilized from human tumors. Cancer Immunol Immunother 7:19-23, 1979.
Roth JA, Zuckerbraun L, Cohn D. Lymphosarcoma presenting as a parotid mass. Ear Nose Throat J 57(10):434-8, 1978. PMID: 581752.
McAvoy JM, Roth JA, Rees WV, Orr F, Dainko EA. Role of ultrasonography in the primary diagnosis of cholelithiasis: an analysis of fifty cases. Am J Surg 136(3):309-12, 1978. PMID: 707695.
McAvoy JM, Fee HJ, Roth JA, Dainko EA. Primary liposarcoma of the omentum. Arch Surg 113(7):870-2, 1978. PMID: 678097.
Roth JA, Morton DL, Holmes EC. Rejection of dinitrochlorobenzene-conjugated syngeneic tumor cells by dinitrochlorobenzene-sensitized guinea pigs. J Surg Res 25(1):1-7, 1978. PMID: 682609.
Roth JA, Eilber FR, Morton DL. Effect of adriamycin and high-dose methotrexate chemotherapy on in vivo and in vitro cell-mediated immunity in cancer patients. Cancer 41(3):814-9, 1978. PMID: 638968.
Roth JA, Feinberg M, McAvoy J. Carcinoma arising in the wall of a breast cyst during pregnancy. Ann Surg 185:247-50, 1977. PMID: 836099.
Roth JA, Grimm EA, Morton DL. A rapid assay for stimulation of human lymphocytes by tumor-associated antigens. Cancer Res 36(9 pt.1):3001-10, 1976. PMID: 975069.
Roth JA, Slocum HK, Pellegrino MA, Holmes EC, Reisfeld RA. Purification of soluble human melanoma-associated antigens. Cancer Res 36(7 PT 1):2360-4, 1976. PMID: 776393.
Roth JA, Silverstein MJ, Morton DL. Metastatic potential of metastases. Surgery 79(6):669-73, 1976. PMID: 179160.
Grimm EA, Silver HK, Roth JA, Chee DO, Gupta RK, Morton DL. Detection of tumor-associated antigen in human melanoma cell line supernatants. Int J Cancer 17(5):559-64, 1976. PMID: 1270174.
Chee DO, Boddie AW, Roth JA, Holmes EC, Morton DL. Production of melanoma-associated antigen(s) by a defined malignant melanoma cell strain grown in chemically defined medium. Cancer Res 36(4):1503-9, 1976. PMID: 1260767.
Roth JA, Golub SH, Grimm EA, Eilber FR, Morton DL. Effects of operation on immune response in cancer patients: sequential evaluation of in vitro lymphocyte function. Surgery 79(1):46-51, 1976. PMID: 128842.
Roth JA, Holmes EC, Reisfeld RA, Slocum HK, Morton DL. Isolation of a soluble tumor-associated antigen from human melanoma. Cancer 37(1):104-10, 1976. PMID: 1247946.
Waldman SR, Roth JA, Kern DH, Pilch YH. Effects on cancer patients of leukapheresis with the continuous-flow blood cell separator. II. Immunologic parameters in vitro. J Lab Clin Med 86(6):950-61, 1975. PMID: 127818.
Waldman SR, Roth JA, Silverstein M, Veltman LL, Pilch YH. Effects on cancer patients of leukapheresis with the continuous-flow blood cell separator. I. Hematologic and immunologic parameters in vivo. J Lab Clin Med 86(6):938-49, 1975. PMID: 1194758.
Williams GM, ter Haar A, Krajewski C, Parks LC, Roth JA. Rejection and repair of endothelium in major vessel transplants. Surgery 78(6):694-706, 1975. PMID: 1188613.
Golub SH, Roth JA, Forsythe A, Morton DL. In vitro monitoring of cellular function during BCG immunotherapy. Bibl Haematol(43):270-3, 1975. PMID: 786261.
Roth JA, Eilber FR, Bennett LR, Morton DL. Radionuclide photoscanning. Usefulness in preoperative evaluation of melanoma patients. Arch Surg 110(10):1211-2, 1975. PMID: 53041.
Roth JA, Holmes EC, Boddie AW, Jr, Morton DL. Lymphocyte responses of lung cancer patients to tumor-associated antigen measured by leucine incorporation. J Thorac Cardiovasc Surg 70(4):613-8, 1975. PMID: 1177475.
Holmes EC, Roth JA, Morton DL. Delayed cutaneous hypersensitivity reactions to melanoma antigen. Surgery 78(2):160-4, 1975. PMID: 1154259.
Roth JA, Eilber FR, Nizze JA, Morton DL. Lack of correlation between skin reactivity to dinitrochlorobenzene and croton oil in patients with cancer. N Engl J Med 293(8):388-9, 1975. PMID: 1152937.
Roth JA, Golub SH, Holmes EC, Morton DL. Effect of bacillus Calmette-Guerin immunotherapy on tumor antigen-induced lymphocyte-stimulated protein synthesis in melanoma patients. Surgery 78(1):66-75, 1975. PMID: 1138401.
Winters WD, Boddie AW, Roth JA, Adams JM. Biological activation of virus-like particles from chemically induced Guinea pig sarcomas. Proc Soc Exp Biol Med 149(3):714-22, 1975. PMID: 806925.
Boddie AW, Jr, Holmes EC, Roth JA, Morton DL. Inhibition of human leukocyte migration in agarose by kcl extracts of carcinoma of the lung. Int J Cancer 15(5):823-9, 1975. PMID: 1140874.
Roth JA, Silverstein MJ, Gupta RK, Morton DL. Restoration of immunocompetency by lymphocyte transfusion. J Surg Oncol 7(1):63-6, 1975. PMID: 1058322.
Roth JA. Patients with hyperbilirubinemia and hyperamylasemia: is the diagnosis pancreatitis or biliary lithiasis?. Am Surg 40(6):321-5, 1974. PMID: 4829710.
Boddie AW, Jr, Holmes EC, Roth JA. Inhibition of human leukocyte migration in agarose by KC1 extracts of lung cancer. Surg Forum 25(0):109-10, 1974. PMID: 4439134.
Roth JA, Golub SH, Grimm EA, Eilber FR, Morton DL. Effect of surgery on in vitro lymphocyte function. Surg Forum 25(0):102-4, 1974. PMID: 4439131.
Roth JA, Rutherford RB. Regional blood flow effects of G suit application during hemorrhagic shock. Surg Gynecol Obstet 133(4):637-43, 1971. PMID: 5096314.
Williams GM, Krajewski CA, Dagher FJ, ter Haar AM, Roth JA, Santos GW. Host repopulation of endothelium. Transplant Proc 3(1):869-72, 1971. PMID: 4937983.
Roth JA, Greenfield AJ, Kaihara S, Wagner HN, Jr. Total and regional cerebral blood flow in unanaesthetized dogs. Am J Physiol 219(1):96-101, 1970. PMID: 4912833.

Invited Articles

Ji L, Roth JA. Tumor suppressor FUS1 signaling pathway. J Thorac Oncol 3(4):327-30, 2008. PMID: 18379348.

Book Chapters

Tsao A, Roth JA. 31 Novel Emerging Agents in NSCLC (including gene therapy). In: Lung Cancer. 4th. Wiley-Blackwell Health Sciences: Hoboken, NJ, 479-487, 2014.
Sobol RE, Guan YS, Li LJ, Zhang WW, Peng Z, Menander KB, Chada S, Zumstein LA, Maneval DC, Horowitz JA, Warren R, Clayman GL, Swisher SG, Goodman WJ, Nemunaitis J, Roth JA. p53 Gene Therapy for Cancer Treatment and Prevention. In: p53 In the Clinics. Springer: New York, NY, 189-208, 2013.
Mehran R, Roth JA. Resection of pulmonary metastases. In: Atlas of Advanced Operative Surgery. 1st. Elsevier, Inc: Philadelphia, PA, 43-49, 2013.
Shirvani SM, Chang JY, Roth JA. Can stereotactic body radiation therapy (SBRT) in early stage lung cancers produce comparable success as surgery?. In: Thoracic Surgery Clinics - Lung Cancer, Part II: Surgery and Adjuvant Therapies. Elsevier Publishers: Philadelphia, PA, 369-381, 2013.
Roth JA, Chang JY. An Issue of Thoracic Surgery Clinics. In: Thoracic Surgery Clinics, devoted to Lung Cancer, Part II: Surgery and Adjuvant Treatment. Elsevier: Philadelphia, PA, 2013.
Kuroda S, Yokoyama T, Tam JO, Scott AW, Ma LL, Shanker M, Roth JA, Sokolov K, Johnston KP,Ramesh R. Multifunctional tumor-targeted nanoparticles for lung cancer. In: Pulmonary Nanomedicine: Diagnostic, Imaging and Therapeutics. Pan Stanford Publishing PTE Ltd: Baltimore, MD, 15-44, 2012.
Ji L, Jayachandran G, Roth JA. High throughput profiling of serum phosphoproteins/peptides using the SELDI-TOF-MS platform. In: SELDI-TOF Mass Spectrometry: Methods in Molecular Biology. Chapter 14. Humana Press: Totowa, NJ, 2012.
Jayachandran G, Roth J, Ji L. Analysis of Protein-Protein Interaction Using ProteinChip Array-Based SELDI-TOF Mass Spectrometry. In: SELDI-TOF Mass Spectrometry: Methods in Molecular Biology. Chapter 15. Humana Press: Totowa, NJ, 2012.
Ramesh R, Shanker M, Jin J, West S, Roth JA. Lipid-based nanocarriers for cancer gene therapy. In: Lipid Nanocarriers in Cancer Diagnosis and Therapy. iSmithers-Creative Publishing Solutions: Lakeland, FL, 169-188, 2011.
Allen M, Cerfolio R, Darling G, Deslauriers J, Duranceau A, Ferguson M, Finley R, Johnston M, Krasna M, Lerut T, Luketich J, Mathisen D, McKenna R, Pearson G, Reed C, Roth J, Rusch V, Sugarbaker D, Ximenes M, Yim A. Building a successful career: Advice from leaders in thoracic surgery. In: Thoracic Surgery Clinics. Elsevier: Maryland Heights, MO, 395-415, 2011.
Ramesh R, Ioannides CG, Roth JA, Chada S. Adenovirus-Mediated Interleukin (IL)-24 Immunotherapy for Cancer. In: Methods Mol Biol. Humana Press: USA, 241-70, 2010.
Roth JA. Cancer of the Lung. In: Cancer Medicine. 8th: New York, 999-1043, 2010.
Lu C, Onn A, Vaporciyan AA, Chang JY, Glisson BS, Komaki R, Wistuba II, Roth JA, Herbst Roy S. Cancer of the Lung. In: Cancer Medicine. 8th, 999-1043, 2010.
Nemunaitis J, Roth JA. Gene-Based Therapies for Lung Cancer. In: Lung Cancer: Prevention, Management and Emerging Therapies. Springer: New York, NY, 305-330, 2009.
Nemunaitis J, Roth J. Vaccine Therapy for Lung Cancer. In: Lung Cancer. Springer: New York, NY, 279-304, 2009.
Roth JA. Gene Therapy Approaches for Lung Cancer. In: Molecular Pathology of Lung Diseases. Springer, 219-225, 2008.
Fang B, Roth JA. Tumor-suppressor gene replacement therapy. In: Viral Therapy of Cancer. John Wiley & Sons, Ltd: London, UK, 229-239, 2008.
Fang B, Roth JA. Adenovector-mediated cancer gene therapy. Chapter 1. In: Cancer Drug Discovery and Development: Gene Therapy for Cancer, 3-22, 2007.
Chang JY, Komaki R, Roth JA, Herbst R Jr, Cox JD. Image guidance of combined modality management of NSCLC. In: Image-guided radiation therapy for lung cancer. US Books and Journals: New York, NY, 1-14, 2007.
Chada S, Bocangel D, Pataer A, Mhashilkar AM, Inoue S, Miyahara R, Roth JA, Grimm EA, Swisher SG, Hunt KK, Ramesh R. MDA-7/IL-24 as a multi-modality therapy for cancer. Chapter 23. In: Cancer Drug Discovery and Development: Gene Therapy of Cancer. Humana Press, Inc: Totowa, NJ, 413-434, 2007.
Roth JA. Targeted genetic therapy for lung cancer. In: Lung Cancer. 3rd. Blackwell Scientific Publishers: Oxford, England, 411-420, 2007.
Chada S, Bocangel D, Menander K, Roth JA. Apoptosis modulators: p53 targeting. In: Targeted Therapies in Oncology. Informa Healthcare USA, Inc. – New York, London - Health Science Division of Taylor and Francis Group: Florence, KY, 177-195, 2007.
Chang JY, Roth JA. Stereotactic body radiation therapy for stage I non-small cell lung cancer. In: Thorac Surg Clin. 2. Elsevier, 251-260, 2007.
Mehran R, Roth JA. Resection of pulmonary metastases (open/thorascopic). In: Atlas of Advanced Operative Surgery. Elsevier, Inc, 2007.
Chada S, Menander KB, Roth J, Ramesh R. Targeting cancer with tumor suppressor genes. In: Gene Therapy. Medical View Co. Ltd: Japan, 266-278, 2007.
Roth JA. Gene therapy for lung cancer. Chapter 36. In: Tumors of the chest: biology, diagnosis, and management. 1st. Springer Verlag, 431-435, 2006.
Moon C, Lee J, Par, Roth JA. . Current status of gene therapy for lung cancer and head and neck cancer. In: About Cancer in Africa. Instut National du Cancer, 673-703, 2006.
Onn A, Vaporciyan AA, Chang JY, Komaki R, Roth JA, Herbst R. Cancer of the lung. Chapter 7. In: Cancer Medicine. Williams & Wilkins, 1179-1225, 2005.
Roth JA, Grammer SF. Tumor suppressor gene replacement for cancer. Chapter 3. In: Contemporary Cancer Research Cancer Gene Therapy. 1st. Humana Press Inc: Totowa, NJ, 19-33, 2005.
Roth JA. Genetics and molecular biology of lung cancer. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. 2nd Fung-Grow. Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 353-368, 2004.
Roth JA, Grammer SF, Merritt JA, Swisher SG. Gene therapy clinical trials for cancer: replacement of tumor suppressor gene, p53 Chapter 38. In: Gene and Cell Therapy. 2nd. Marcel Dekker, Inc: New York, NY, 743-752, 2004.
Roth JA Grammer SF. Tumor suppressor gene therapy, Regulation, Function and Medicinal Applications. In: Methods in Molecular Biology. Humana Press, Inc: Totowa, NJ, 577-598, 2003.
Vaporciyan AA, Kies M, Stevens C, Komaki R, Roth JA. Cancer of the lung. In: Cancer Medicine. BC Decker Inc: Hamilton, Ontario, Canada, 1385-1446, 2003.
Putnam JB, Roth JA. Pulmonary metastases. In: Surgical Oncology: Multidisciplinary Approach to Difficult Problems. Arnold Publishers: London, England, 742-764, 2002.
Roth JA, Grammer SF, Merritt J, Swisher SG. Gene therapy clinical trials for cancer: replacement of tumor suppressor gene p53. In: Gene and Cell Therapy Therapeutic Mechanisms and Strategies. 2nd. Marcel Dekker, Inc: New York, NY, 743-752, 2002.
Swisher SG, Roth JA. Adenoviral p53 gene therapy strategies in non small-cell lung cancer, Chapter 19. In: Chemoradiation in Cancer Therapy. Humana Press, Inc: Totowa, NJ, 349-358, 2002.
Fang B, Roth JA. Gene therapy. In: Molecular Basis of Cancer. 2nd. WB Saunders Company: Philadelphia, PA, 589-604, 2001.
Roth JA. Gene therapy approaches for the management of cancer. In: ASCO Spring Education Book, 558-5645, 2001.
Roth JA, Grammer SF. Gene therapy: tumor suppressor gene replacement and oncogene suppression, Chapter 98. In: The Cancer Handbook. MacMillan: London, England, 1521-1531, 2001.
Swisher SG, Grammer SF, Roth JA. Ad-p53 gene transfer strategies for non-small-cell lung cancer. In: American Society of Clinical Oncology, 412-417, 2001.
Roth JA. Lung Cancer "Biology of Lung Cancer" Chapter 31. In: Thoracic Surgery. Elsevier, 772-783, 2001.
Fang B, Roth JA. Gene therapy using direct in vivo gene injection. In: Principles and Practice of the Biologic Therapy of Cancer. 3rd. Lippincott Williams & Wilkins: Philadelphia PA, 796-810, 2000.
Roth JA, Molldrem J, Smythe R. The current status of cancer gene therapy trials Chapter 13. In: Cancer: Principles & Practice of Oncology. 2nd. Lippincott-Raven: Philadelphia, PA, 2-15, 2000.
Vaporciyan AA, Nesbitt JC, Lee JS, Stevens C, Komaki R, Roth JA. Cancer of the lung. In: Cancer Medicine. 5th. Decker Inc: Ontario, Canada, 1227-1292, 2000.
Roth JA. Cancer Biology. In: Thoracic Surgery Esophageal Surgery. 2nd. WB Saunders Co: New York, NY, 637-647, 1999.
Pollock RE, Balch CM, Roth JA, McPeek B, Mosteller F. Formulating an initial research plan. In: Surgical Research: Basic Principles and Clinical Practice. Third. Springer: New York, New York, 363-365, 1998.
Mukhopadhyay T, Roth JA. Ribozymes in targeting tumor suppressor genes. In: Ribozymes in the Gene Therapy of Cancer. RG Landes Co: Georgetown, 175-182, 1998.
Roth JA. The molecular biology of lung cancer. In: The Encyclopedia of Molecular Biology. Chernow Editorial Services, Inc: New York, NY, 1998.
Roth JA. Genetic manipulations for the treatment of lung cancer. In: Lung Cancer. Blackwell Science Inc: Cambridge, MA, 369-381, 1998.
Roth JA. Defective tumor suppressor gene replacement and oncogene inactivation for the treatment of cancer. In: Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors. Marcel Dekker, Inc: New York, NY, 279-294, 1998.
Schrump DS, Roth JA. Gene therapy of lung cancer. In: Biology of Lung Cancer. Marcel Dekker, Inc: New York, NY, 171-185, 1998.
Swisher SG, Roth JA. Role of gene therapy in lung cancer. In: Advanced Therapy in Thoracic Surgery. Marcel Decker, Inc: Hamilton, Ontario, Canada, 139-145, 1998.
Cristiano RJ, Nguyen D, Spitz F, Roth JA. Gene therapy: its interactions with chemotherapy. In: Infusion chemotherapy-irradiation interactions. Elsevier Science, 175-182, 1998.
Maxwell SA, Roth JA. Oncogene interactions with tumor suppressor genes. In: Encyclopedia of Cancer. Academic Press, Inc: San Diego, CA, 1161-1171, 1997.
Mukhopadhyay T, Roth JA. Isolation of total RNA from tissues or cell lines: visualization in Gel. In: Methods in Molecular Biology: RNA Isolation and Characterization Protocols. Humana Press Inc: Ottowa, Canada, 55-59, 1997.
Putnam JB Jr, Morris P, Roth JA. Esophageal carcinoma. In: Difficult Problems in Surgical Oncology. Chapman & Hill: New York, NY, 1997.
Zhang WW, Roth JA. Methods for cancer gene therapy using tumor suppressor genes. In: Gene Therapy Protocols. Humana Press: Ottowa, Canada, 403-418, 1997.
Ajani JA, Roth JA, Ryan B, McMurtrey M, Rich TA. Resectable adenocarcinoma of the esophagus: a study of pre- and postoperative chemotherapy. In: Adjuvant Therapy of Cancer VI. WB Saunders Co: Philadelphia, PA, 396-404, 1996.
Balch CM, Milton GW, Roth JA. Surgery for metastatic melanoma. In: Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide. JB Lippincott Co: Philadelphia, PA, 1996.
Nesbitt JC, Lee JS, Komaki R, Roth JA. Cancer of the Lung. In: Cancer Medicine. Williams & Wilkins: Baltimore, MD, 3-83, 1996.
Roth JA. Gene replacement strategies for prevention and treatment of aerodigestive tract cancers. In: Accomplishments in Cancer Research. JB Lippincott Co: Philadelphia, PA, 188-199, 1996.
Roth JA. Lung cancer, molecular biology of. In: Encyclopedia of Molecular Biology and Molecular Medicine. VCH Verlagsesellschaft: Weinheim, Federal Republic of Germany, 491-497, 1996.
Roth JA, Mukhopadhyay T, Casson AG, Chung KY. Molecular strategies for the prevention and therapy of cancer. In: Gene Therapy of Cancer. Appleton and Lange, 1996.
Roth JA ,Putnam Jr JB. Pulmonary resection for metastatic disease. In: Difficult Problems in Surgical Oncology. Chapman and Hill: New York, NY, 1996.
Roth JA, Putnam JB Jr, Rich TA, Forastiere AA. Cancer: cancer of the esophagus. In: Cancer: Principles and Practices of Oncology. Lippincott – Raven Press: Philadelphia, PA, 980-1010, 1996.
Ajani JA, Kelsen DP, Rich TA, Roth JA. Chemotherapy and combined modality therapy for squamous cell carcinoma and adenocarcinoma of the esophagus and gastroesophageal junction. In: Anonymous Thoracic Oncology. WB Saunders: Philadelphia, PA, 433-441, 1995.
Nesbitt JC, Putnam JB Jr, Walsh GL, Ryan MB, Roth JA. Malignant diseases of the lung. In: Current Practice of Surgery. Churchill Livingstone, Inc: New York, NY, 1-54, 1995.
Putnam JB Jr, Roth JA. Neoplasms of the esophagus. In: Digestive Tract Surgery: A Text and Atlas. Lippincott-Raven: Philadelphia, PA, 43-76, 1995.
Roth JA. The molecular biology of lung cancer. In: Molecular Biology and Molecular Medicine. VCH Publishers, Inc: New York, NY, 518-521, 1995.
Roth JA. Molecular biology and biotechnology. In: Lung Cancer, Molecular Biology of. VCH: New York, NY, 518-521, 1995.
Roth JA, Mukhopadhyay T, Zhang WW, Fujiwara T, Georges R. Gene replacement strategies for the prevention and therapy of cancer. In: The Internet Book of Gene Therapy Cancer Therapeutics. Appleton & Lange: Stamford, Connecticut, 229-234, 1995.
Roth JA, Putnam JB. Surgery for carcinoma of the esophagus. In: Anonymous Thoracic Oncology. WB Saunders: Philadelphia, PA, 397-413, 1995.
Schrump DS, Roth JA. Clinical implications of molecular events in lung cancer. In: Molecular Basis of Oncology. Blackwell Scientific Publications, Inc: Boston, MA, 295-316, 1995.
Schrump DS, Roth JA. Molecular biology and immunology of lung and esophageal cancer. In: Glenn’s Thoracic and Cardiovascular Surgery. 6. Appleton & Lange: Stamford, Connecticut, 331-343, 1995.
Walsh GL, Roth JA. General principles and surgical considerations in the management of mediastinal masses. In: Thoracic Oncology. 2nd. WB. Saunders: Philadelphia, PA, 445-467, 1995.
Roth JA. Molecular genetic strategies for the prevention and therapy of lung cancer. In: Lung Cancer: Frontiers in Science and Treatment. Grafica L.P: Genoa, Italy, 83-90, 1994.
Putnam JB Jr, Roth JA. Secondary tumors in the lungs. In: General Thoracic Surgery. Williams & Wilkins: Philadelphia, PA, 1334-1352, 1994.
Putnam JB, Roth JA. Surgical resection of pulmonary metastases. In: Cancer Surgery. JB Lippincott Co: Philadelphia, PA, 337-350, 1994.
Roth JA. The esophageal mucosa. In: Anonymous O.E.S.O. Elsevier: Amsterdam, The Netherlands, 1093-1096, 1994.
Roth JA. Is an initial multifocal or diffuse appearance characteristics of adenocarcinoma in CLE?. In: The Esophageal Mucosa. Elsevier: Amsterdam, 1093-1996, 1994.
Roth JA, Mukhopadhyay T, Casson AG, Chung KY. Molecular strategies for early detection, prevention and therapy cancer. In: Early Detection of Cancer: Molecular Markers. Armok, Futura Publishing Company, Inc, 45-52, 1994.
Roth JA, Putnam JB Jr. New insights into selecting patients likely to benefit from resection of pulmonary metastases. In: Lung Cancer: Frontiers in Science and Treatment: Genoa, Italy, 473-482, 1994.
Zhang Y, Mukhopadhyay T, Georges R, Roth JA. Molecular targeting of cancer: retroviral vector-mediated antisense nucleic acid therapy. In: Gene Therapy: From Lab to the Clinic. World Scientific Publishing Company: Singapore, 70-106, 1994.
Mukhopadhyay T, Roth JA. p53 gene mutations in human premalignant and malignant tissues. In: Methods in Molecular Genetics. Academic Press, Inc: Orlando, FL, 104-128, 1993.
Putnam JB Jr, Roth JA. Neoplastic diseases of the esophagus. In: Digestive Tract Surgery: A Text and Atlas. JB Lippincott: Philadelphia PA, 43-75, 1993.
Putnam JB, Ryan MB, Walsh GL, Roth JA. Malignant disease of the lung. In: Current Practices of Surgery. Churchill Livingstone, Inc: New York, NY, 1-44, 1993.
Roth JA. The biology of lung cancer. In: Thoracic Surgery, 637-647, 1993.
Roth JA. Advances in cell and molecular biology of non-small cell lung cancer. In: Advances in Diagnosis and Therapy of Lung Cancer. Blackwell Scientific: Cambridge, MA, 85-104, 1993.
Roth JA, Putnam JB Jr. Cancer of the esophagus. In: Cancer: Principles & Practice of Oncology. JB Lippincott Co: Philadelphia, PA, 776-817, 1993.
Yang SC, Grimm E, Roth JA. Immunotherapy of lung cancer. In: Advances in Diagnosis and Therapy of Lung Cancer. Blackwell Scientific: Cambridge, MA, 379-390, 1993.
Putnam JB, Roth JA. Resection of pulmonary metastases. In: Current Therapy in Oncology. BC Becker: Philadelphia, PA, 197-201, 1992.
Roth JA, Sugarbaker PH, Baker AR. Radical forequarter amputation with chest wall resection. In: Anonymous Musculoskeletal Surgery for Cancer. Thieme Medical Publishers, Inc: New York, NY, 317-324, 1992.
Pollock RE, Balch CM, Roth J, McPeek B, Mosteller F. Formulating an initial research plan. In: Principles and Practices of Research: Strategies for Surgical Investigators. Second. Springer-Verlag: New York, NY, 88-90, 1991.
Roth JA. Treatment of metastatic cancer: treatment of metastatic cancer to lung. In: Cancer: Principles and Practice of Oncology. JB Lippincott Co: Philadelphia, PA, 2261-2275, 1989.
Roth JA. Solitary pulmonary nodule. In: Common Problems in Gastrointestinal Surgery. Year Book Medical Publishers, 53-58, 1989.
Roth JA, Pass HI, Flanagan MM, Graeber GM, Rosenberg JC, Steinberg S. Clinical trials with cisplatin, vindesine, and bleomycin neoadjuvant chemotherapy for epidermoid carcinoma of the esophagus. In: Gastrointestinal Cancer: Current Approaches to Diagnosis and Treatment. University of Texas Press: Houston, TX, 253-259, 1989.
Sugarbaker PH, Roth JA. Specialized techniques of cancer management: endoscopy. In: Cancer: Principles and Practice of Oncology. JB Lippincott Co: Philadelphia, PA, 423-440, 1989.
Moody FG, Roth JA. The esophagus and diaphragmatic hernias. In: Hardy’s Textbook of Surgery. 2nd. James D. Hardy, 485-513, 1988.
Roth JA. Prognostic indicators for soft tissue sarcoma patients with pulmonary metastases. In: Recent Concepts in Sarcoma Treatment. Kluwer Academic Publishers: Boston, MA, 191-196, 1988.
Roth JA. Resection of pulmonary metastases. In: Thoracic Oncology. WB Saunders Co, 619-630, 1988.
Roth JA, Kelsen DP. Surgery and adjuvant chemotherapy for carcinoma of the esophagus. In: Thoracic Oncology. WB Saunders Co, 379-394, 1988.
Ajani JA, McMurtrey MJ, Rich TA, Blackburn R, Chang-Tung E, Levin B, Roth JA, Mountain CF. Carcinoma of the esophagus: Contribution of chemotherapy. In: Gastrointestinal Cancer: Current Approaches to Diagnosis and Treatment. University of Texas Press: Houston, TX, 273-281, 1988.
Kern KA, Pass HI, Roth JA. Surgical treatment of pulmonary metastases. In: Surgical Treatment of Metastatic Cancer. JB Lippincott Co: Philadelphia, PA, 69-100, 1987.
Ognibene FP, Pass HI, Roth JA, Shelhamer JH. The diagnosis and therapy of respiratory disease in the immunosuppressed host. In: The Critically Ill Immunosuppressed Patient. Aspen Publications: Aspen, CO, 39-80, 1987.
Pass HI, Roth JA. Diagnosis of pulmonary metastases. In: Surgical Treatment of Metastatic Cancer. JB Lippincott Co: Philadelphia, PA, 36-67, 1987.
Roth JA. Oncogenes and monoclonal antibodies. In: Monoclonal Antibodies for the Diagnosis and Therapy for Cancer. Futura Publishing Co, Inc: Mount Kisco, NY, 289-321, 1987.
Grimm EA, Roth JA, Yagita M. Effect of OK-432 activated cytolytic lymphocytes on NK resistant fresh tumor cells. In: Host Defense Mechanisms and Immunopotentiators. University of Tokyo Press: Tokyo, Japan, 67-74, 1986.
Roth JA. Oncogenes and monoclonal antibodies. In: Monoclonal Antibodies in Cancer: Advances in Diagnosis and Treatment. Futura Publishing Company, Inc: Mount Kisco, NY, 1986.
Balch CM, Milton GW, Roth JA. Diagnosis of metastatic melanoma at distant sites. In: Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide. JB Lippincott Co: Philadelphia, PA, 221-250, 1985.
Rosenberg JC, Roth JA, Lichter AS, Kelsen DP. Cancer of the esophagus. In: Cancer: Principles and Practice of Oncology. JB Lippincott Co: Philadelphia, PA, 621-657, 1985.
Roth JA. Treatment of pulmonary metastases. In: Cancer: Principles and Practices of Oncology. JB Lippincott Co: Philadelphia, PA, 2117-2131, 1985.
Roth JA. Treatment of metastatic cancer: treatment of metastatic cancer to lung. In: Cancer: Principles and Practice of Oncology. JB Lippincott Co: Philadelphia, PA, 2104-2117, 1985.
Roth JA. Endoscopy for thoracic oncologic diseases. In: Cancer: Principles and Practices of Oncology. JB Lippincott Co: Philadelphia, PA, 353-406, 1985.
Sugarbaker PH, Roth JA. Specialized techniques of diagnosis: endoscopy. In: Cancer: Principles and Practices of Oncology. JB Lippincott Co: Philadelphia, PA, 353-374, 1985.
Roth JA, Sugarbaker PH, Baker AR. Radical forequarter amputation with chest wall resection. In: Atlas of Extremity Sarcoma Surgery. JB Lippincott Co: Philadelphia, PA, 177-191, 1984.
Lara-Guerra H, Roth J. Gene Therapy for the Treatment of Lung Cancer. In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th. Taylor & Francis/CRC Press.

Books (edited and written)

Roth JA, Komaki R, Hong WK. Lung Cancer. Ed(s) Roth JA, Komaki R, Hong WK. 4th. Wiley-Blackwell Health Sciences: Hoboken, NJ, 2014.
Albelda SM, Andreef M, Aref I, Barton K, Brown S, Chiocca EA, Curiel DT, Dembinski J, Desai A, Ekmekcioglu S, Ellerhorst J, Elshaikh M, Freytag SO, Fueyo J, Fujiwara T, Gerson S, Grimm EA, Haas AR, Hall B, Ji L, Jiang H, Kaur B, Kidd S, Kim JH, Kim K, Klopp A, Lang F, Lin Y, Ling X, Lopez-Berestein G, Lu M, Mangala LS, Marini F, Moon EK, Mora EM, Movsas B, Nemunaitis J, Poindexter N, Pollock RE, Price RL, Ramesh R, Rao DD, Roth JA, Senzer N, Shay JW, Siddiqui F, Singhal S, Sood AK, Spaeth E, Sterman DH, Stricker H, Studeny M, Thacker EE, Torres KE, Vorhies JS, Zeng Z. Gene-Based Therapies for Cancer. In: Current Cancer Research. Ed(s) Roth JA. 1st. Springer: New York, New York, 2010.
Roth JA, Hong WK, Cox CD. Lung Cancer. 3rd. Blackwell Scientific Publishers: Oxford, England, 2007.
Roth JA, Hong WK, Cox CD. Lung Cancer. 2nd. Blackwell Scientific Publishers, Inc: Oxford England, 1998.
Mukhopadhyay T, Maxwell SA, Roth JA. p53 Suppressor Gene. RG Landes Co: Austin, TX, 1995.
Roth JA, Ruckdeschel J, Weisenburger T. Thoracic Oncology. 2nd. WB Saunders Co: Philadelphia, PA, 1995.
Roth JA, Hong WK, Cox CD. Lung Cancer. 1st. Blackwell Scientific Publishers, Inc: Oxford, England, 1993.
Roth JA, Ruckdeschel J, Weisenburger T. Thoracic Oncology. 1st. WB Saunders Co: Philadelphia, PA, 1988.
Roth JA. Monoclonal Antibodies for the Diagnosis and Therapy of Cancer. Futura Publishing Company, Inc: Mount Kisco, NY, 1987.

Less

Grant & Contract Support

Title:	Epigenetic miRNA, SNP Signatures, and their Functions in Lung Cancer Outcomes
Funding Source:	NIH/NCI
Role:	Multi-Principal Investigator

Title:	PDXNet: Project 1: PDX-based trials of precision medicine for treatment of KRAS mutant lung cancers
Funding Source:	NIH/NCI
Role:	Co-Investigator

Title:	University of Texas PDX Development and Trial Center - Pilot Core
Funding Source:	NIH/NCI
Role:	Core Leader

Title:	University of Texas PDX Development and Trial Center - Admin Core
Funding Source:	NIH/NCI
Role:	Co-Core Leader

Title:	Novel Therapeutic Approaches for the Treatment of Cancer Using TUSC2 and Immunotherapy
Funding Source:	Genprex, Inc
Role:	Principal Investigator

Title:	University of Texas PDX Development and Trial Center
Funding Source:	NIH/NCI
Role:	Principal Investigator

Title:	Bay Area Team Against Resistance: Overcoming Resistance to Tyrosine Kinase Inhibitors in Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer
Funding Source:	NIH/NCI
Role:	Principal Investigator

Title:	SPORE: Targeting Lung Cancer Vulnerabilities
Funding Source:	NIH/NCI
Role:	MPI

CV information above last modified August 14, 2024

Jack A. Roth, M.D., F.A.C.S.

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Jack A. Roth, M.D., F.A.C.S.

About Dr. Jack A. Roth

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Research Interests

Clinical Interests

Education & Training

Degree-Granting Education

Postgraduate Training

Board Certifications

Experience & Service

Academic Appointments

Administrative Appointments/Responsibilities

Other Appointments/Responsibilities

Institutional Committee Activities

Military or Other Governmental Service

Honors & Awards

Professional Memberships

Selected Publications

Peer-Reviewed Articles

Invited Articles

Book Chapters

Books (edited and written)

Grant & Contract Support

Patient Reviews

Request an Appointment

Related Links

Care Centers and Clinics

Departments and Divisions

Labs

Clinical Trials

Help #EndCancer

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