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Jared K. Burks, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Flow Cytometry & Cell Imaging Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

My PhD research was in protein trafficking during viral infection.  This allowed me to help discover a new type of shuttling protein called importin-alpha 16, which is believed to be responsible for trafficking integral membrane proteins through the lateral channel of the nuclear pore complex.  During my post-doctoral work I studied nuclear p53 protein-protein interactions in CMV infected human endothelial cells.  I have utilized advanced imaging techniques throughout my career in science, over 16 years.  After my post-doctoral work I joined the Flow Cytometry and Cellular Imaging Core as a research scientist primarily directing the imaging research.  I have attended specific courses on both advanced imaging and flow cytometry.  I have recently been promoted to Co-director of the North Campus Flow Cytometry and Cellular Imaging Core due to my knowledge of imaging and cytometry  as well as my ability to organize and direct the facility.

Education & Training

Degree-Granting Education

2005 Texas A&M University, College Station, TX, PHD, Biology
1995 Florida Institute of Technology, Melbourne, FL, BS, Molecular Biology
1995 Florida Institute of Technology, Melbourne, FL, BS, Pre-Professional Biology

Postgraduate Training

1/2006-7/2007 Postdoctoral Associate, Baylor College of Medicine, Houston, TX

Experience/Service

Other Appointments/Responsibilities

Research Scientist, Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2007-2010
Postdoctoral Associate, Baylor College of Medicine - Division of Cardiothoracic Surgery - Michael DeBakey Department of Surgery, Houston, TX, 1/2006-7/2007
Research Assistant, The Max D. Summers Laboratory, Department of Entomology, College Station, TX, 11/1995-8/1998
Necropsy Assistant, Arkansas Livestock and Poultry Pathology Laboratory, Little Rock, AR, 1993
Laboratory Assistant, Medical Genetics Laboratory, Department of Biology, Melbourne, FL, 1990-1994

Honors and Awards

2004 American Society of Virology, 2004 Annual Meeting, McGill University, Montreal, Canada
2003 Entomology Graduate Student Forum Presentation Award, Texas A&M University

Professional Memberships

American Society of Microbiology
Member, 1998-2003
American Society of Virology
Member, 2000-2005
Texas A&M University Light Microscopy Users Group, TX
Student Rep, 2002-2004

Selected Publications

Peer-Reviewed Original Research Articles

1. Berlin J, Du Z, Molkentine D, Marcano D, Price B, Burks JK, Pham T, Delk N, Raju U, Milas L, Tour J. Large protein transfection with surface modified ultra-small carbon nanomaterials. Journal of the American Chemical Society. In Press.
2. Ruvolo PP, Ruvolo VR, Jacamo R,Burks JK , Zheng Z, Duvvuri SR, Zhou L, Qiu Y, Coombes KR, Zhang N, Yoo SY, Pan R, Hail N, Konopleva M, Calin G, Kornblau SM, Andreeff M. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Biochim Biophys Acta. e-Pub 5/2014. PMID: 24858343.
3. Mak PY, Mak DH, Mu H, Shi Y, Ruvolo P, Ruvolo V, Jacamo R, Burks JK, Wei W, Huang X, Kornblau SM, Andreeff M, Carter BZ. Apoptosis Repressor with Caspase Recruitment Domain Is Regulated by MAPK/PI3K and Confers Drug Resistance and Survival Advantage to AML. Apoptosis 19(4):698-707, 4/2014. e-Pub 12/2013. PMCID: PMC3943601.
4. Shah N, Martin-Antonio B, Yang H, Ku S, Lee D, Cooper L, Decker W, Li S, Robinson S, Sekine T, Parmar S, Gribben J, Wang M, Rezvani K, Yvon E, Najjar A, Burks JK , Kaur I, Champlin R, Bollard C, Shpall E. Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity. PLOS ONE 8(10):1-9, 10/2013.
5. Kojima K, Kornblau SM, Ruvolo V, Dilip A, Duvvuri S, Davis RE, Zhang M, Wang Z, Coombes KR, Zhang N, Qiu YH, Burks JK, Kantarjian H, Shacham S, Kauffman M, Andreeff M. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood 121(20):4166-74, 5/2013. e-Pub 4/2013. PMCID: PMC3656451.
6. Mazurek N, Byrd JC, Sun Y, Hafley M, Ramirez K, Burks JK , Bresalier RS. Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ 19(3):523-33, 3/2012. e-Pub 9/2011. PMCID: PMC3246527.
7. Kidd S, Spaeth E, Watson K, Burks JK, Lu H, Klopp A, Andreeff M, Marini FC. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7(2):e30563, 2012. e-Pub 2/2012. PMCID: PMC3282707.
8. Ruvolo PP, Zhou L, Watt JC, Ruvolo VR, Burks JK, Jiffar T, Kornblau S, Konopleva M, Andreeff M. Targeting PKC Mediated Signal Transduction Pathways Using Enzastaurin to Promote Apoptosis in Acute Myeloid Leukemia-derived Cell Lines and Blast Cells. J Cell Biochem 112(6):1696-707, 6/2011. e-Pub 2/2011. PMID: 21360576.
9. Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM. Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother 33(7):684-96, 9/2010. PMID: 20664358.
10. Kojima K, Burks JK, Arts J, Andreeff M. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther 9(9):2545-57, 9/2010. e-Pub 8/2010. PMCID: PMC2949269.
11. Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70(6):2424-34, 3/2010. e-Pub 3/2010. PMCID: PMC2840060.
12. Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks J, Clise-Dwyer K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-ß Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron 3(1):83-95, 2010. e-Pub 3/2010. PMCID: PMC2990497.
13. Serda RE, Gu J, Burks JK, Ferrari K, Ferrari C, Ferrari M. Quantitative mechanics of endothelial phagocytosis of silicon microparticles. Cytometry A 75(9):752-60, 9/2009. PMCID: PMC2804906.
14. Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 113(7):1504-12, 2/2009. e-Pub 10/2008. PMCID: PMC2644078.
15. Zhang C, Zhang MX, Shen YH, Burks JK, Li XN, LeMaire SA, Yoshimura K, Aoki H, Matsuzaki M, An FS, Engler DA, Matsunami RK, Coselli JS, Zhang Y, Wang XL. Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. Biochim Biophys Acta 1783(8):1517-28, 8/2008. e-Pub 3/2008. PMCID: PMC2587084.
16. Zhang C, Zhang MX, Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol 27(8):1760-7, 8/2007. e-Pub 5/2007. PMCID: PMC2597036.
17. Burks JK, Summers MD, Braunagel SC. BV/ODV-E26: a palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus. Virology 361(1):194-203, 4/2007. e-Pub 12/2006. PMID: 17169392.
18. Saksena S, Summers MD, Burks JK, Johnson AE, Braunagel SC. Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol 13(6):500-8, 6/2006. e-Pub 5/2006. PMID: 16715095.
19. Braunagel SC, Burks JK , Rosas-Acosta G, Harrison RL, Ma H, Summers MD. Mutations within the Autographa californica nucleopolyhedrovirus FP25K gene decrease the accumulation of ODV-E66 and alter its intranuclear transport. J Virol 73(10):8559-70, 10/1999. PMCID: PMC112876.
20. Xing D, Ramsay A, Decker W, Lee D, Burks JK, Sufang L, Shah N, Robinson S, Yang H, Ma Q, Champlin R, Bollard C, Gribben J, Shpall E. Acute myeloid leukemia NK-cells exhibit impaired lytic immunological synapse formation reversible with CD137 ligand stimulation. Journal of Clinical Investigation (61741-RG-1). Submitted.
21. Kidd S; Spaeth EL; Watson K; Burks JK ; Lu H; Klopp A; Andreeff M; Marini F. Dissecting the Tumor Microenvironment through Multicolor Cellular Transplants Reveals Disparate Origins of Tumor Associated Stromal Mesenchyme. PLoS ONE. Submitted.
22. PP Ruvolo, VR Ruvolo, R Jacamo, Burks JK , SR Duvvuri, L Zhou, YH Qiu, KR Coombes, N Zhang, SY Yoo, N Hail, Jr., G Calin, SM Kornblau, and M Andreeff. The protein phosphatase 2A regulatory subunit B55α is a modulator of cell signaling, microRNA. Leukemia. Submitted.
Other Articles
1. Andreeff M, Zeng Z, Tabe Y, Samudio I, Fiegl M, Watt J, Dietrich, M., McQueen T, Frolova O, Battula L, Mnjoyan Z, Shi Y-X, Konoplev S, Burks JK, Konopleva M. Microenvironment and leukemia: Yin and yang. Ann Hematol Suppl:1: S94-S98, 2008.

Abstracts

1. Zhang W, Konopleva M, Burks JK, Dywer K, Schober W, Yang JY, McQueen T, Hung MC, Andreeff M. Apoptosis induction in acute myeloid leukemia by inhibition of MEK and MDM2 is strongly associated with the BH3-only proteins Puma and Bim. 2008.
2. Ramsay AG, Xing D-X, Decker WK, Burks JK, Wierda WG, Gribben JG, Shpall EJ. Compared to Adult Peripheral Blood T Cells, Cord Blood T Cells Show Enhanced Immunological Recognition of Chronic Lymphocytic Leukemia Tumor Cells. 112(2333), 2008.
3. Fiegl M, Samudio IJ, Dwyer KC, Burks JK, Fritsche H, Mnjoyan ZH, Andreeff M. CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia. Blood 112(11), 2008.
4. Zhang M-X, Zhang C, Shen YH, Zhang L, Burks JK, Wang J, Coselli JS, Wang XL. Endogenous 27nt microRNA inhibits eNOS Expression through DNA Methylation. 2006.
5. Zhang M-X, Shen YH, Zhang C, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL. Endogenous eNOS-Specific 27nt MicroRNA is derived through Pre-mRNA Splicing. 2006.
6. Braunagel SC, Saksena S, Burks JK, Johnson AE, Summers MD. Importin alpha-16: a translocon-associated protein potentially involved in sorting integral membrane proteins to the nuclear envelope. 2006.
7. Zhang C, Zhang M-X, Shen YH, Burks JK, Zhang Y, LeMaire SA, Coselli JS, Wang XL. TNF{alpha} Suppresses Prolyl-4-Hydroxylase a (I) (P4Ha(I)) Expression and Collagen Processing in Aortic SMCs via JNK Pathway. 2006.

Book Chapters

1. Burks JK. Imaging tools for cellular uptake and intracellular trafficking. In: Mass transport of Nanocarriers. Ed(s) Rita Serder. Pan Stanford Publishing Pte. Ltd. In Press.

Grant & Contract Support

Title: Cancer Center Support Grant, PP-SR-12; Flow Cytometry and Cellular Imaging Facility
Funding Source: NIH/NCI
Role: Co-Shared Resource Director
Principal Investigator: Ronald A. DePinho, MD
Duration: 7/1/2013 - 6/30/2018
 
Title: CyTOF Mass Cytometer and Element Tagging System
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Michael Andreeff, MD, PhD
Duration: 6/1/2012 - 5/31/2015
 
Title: Cancer Center Support Grant, PP-SR-12; Flow Cytometry and Cellular Imaging Facility
Funding Source: NIH/NCI
Role: Co-Shared Resource Director
Principal Investigator: Ronald A. DePinho, MD
Duration: 7/1/2008 - 6/30/2013

Last updated: 6/10/2014